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Tsujimura, Taro
Institute for Advanced Study Program-Specific Senior Lecturer/Program-Specific Junior Associate Professor
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Last Updated :2025/05/02
Basic Information
Professional Memberships
Academic Degree
Research History
- From Dec. 2019, To PresentKyoto University, KUIAS, Junior Associate Professor
- From Feb. 2017, To Nov. 2019Keio University, School of Medicine, Research Assistant Professor
- From May 2014, To Jan. 2017The University of Tokyo Hospital, 先端腎臓・再生医学講座, 特任助教
- From May 2009, To Apr. 2014EMBL Heidelberg, Spitz Group, Developmental Biology Unit, Postdoctoral Fellow
- From Apr. 2009, To Apr. 2009東京大学新領域創成科学研究科先端生命科学専攻, 人類進化システム分野, 客員博士研究員
- From Apr. 2008, To Mar. 2009東京大学新領域創成科学研究科先端生命科学専攻, 人類進化システム分野, 日本学術振興会 特別研究員 PD
- From Apr. 2007, To Mar. 2008東京大学新領域創成科学研究科先端生命科学専攻, 人類進化システム分野, 日本学術振興会 特別研究員 DC2
- From Apr. 2005, To Mar. 2007東京大学新領域創成科学研究科, 21世紀COEプログラムリサーチアシスタント
Profile
Profile
My research interest is to understand cis-interaction and gain insights into evolution and human diseases by genomic rearrangements.
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ORCID ID
J-Global ID
Researcher number
90741893
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Last Updated :2025/05/02
Research
Research Topics, Overview of the research
Research Topics
3D (epi-)genome at single-cell resolutionOverview of the research
My research interest is to understand full spectrum of cis-interaction to gain insights into evolution and human diseases by genomic rearrangements. The field of epigenomics is being accelerated by rapid revolution of technology to analyze the epigenomic and transcriptomic states of individual cells. I am also engaged in development of novel analytical tools for single-cell epigenomics. Taking advantage of the collaborative environment at ASHBi, I would like to apply these techniques for the the studies of myself and others, to establish a cutting-edge concept in the field of human biology.
Research Interests
Research Areas
Papers
- Non-viral generation of transgenic non-human primates via the piggyBac transposon system.Masataka Nakaya; Chizuru Iwatani; Setsuko Tsukiyama-Fujii; Ai Mieda; Shoko Tarumoto; Taro Tsujimura; Takuya Yamamoto; Takafumi Ichikawa; Tomonori Nakamura; Ichiro Terakado; Ikuo Kawamoto; Takahiro Nakagawa; Iori Itagaki; Mitinori Saitou; Hideaki Tsuchiya; Tomoyuki TsukiyamaNature communications, 24 Mar. 2025
- In vitro reconstitution of epigenetic reprogramming in the human germ line.Yusuke Murase; Ryuta Yokogawa; Yukihiro Yabuta; Masahiro Nagano; Yoshitaka Katou; Manami Mizuyama; Ayaka Kitamura; Pimpitcha Puangsricharoen; Chika Yamashiro; Bo Hu; Ken Mizuta; Taro Tsujimura; Takuya Yamamoto; Kosuke Ogata; Yasushi Ishihama; Mitinori SaitouNature, 20 May 2024
- Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys.Sayuri Gyobu-Motani; Yukihiro Yabuta; Ken Mizuta; Yoshitaka Katou; Ikuhiro Okamoto; Masanori Kawasaki; Ayaka Kitamura; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Taro Tsujimura; Takuya Yamamoto; Tomonori Nakamura; Mitinori SaitouThe EMBO journal, 16 Mar. 2023
- Reconstituting human somitogenesis in vitro.Yoshihiro Yamanaka; Sofiane Hamidi; Kumiko Yoshioka-Kobayashi; Sirajam Munira; Kazunori Sunadome; Yi Zhang; Yuzuru Kurokawa; Rolf Ericsson; Ai Mieda; Jamie L Thompson; Janet Kerwin; Steven Lisgo; Takuya Yamamoto; Naomi Moris; Alfonso Martinez-Arias; Taro Tsujimura; Cantas AlevNature, Feb. 2023
- Mechanistic insights into the evolution of the differential expression of tandemly arrayed cone opsin genes in zebrafishTaro TsujimuraDevelopment, Growth & Differentiation, Oct. 2020
- Controlling gene activation by enhancers through a drug-inducible topological insulator.Taro Tsujimura; Osamu Takase; Masahiro Yoshikawa; Etsuko Sano; Matsuhiko Hayashi; Kazuto Hoshi; Tsuyoshi Takato; Atsushi Toyoda; Hideyuki Okano; Keiichi HishikawaeLife, 05 May 2020, Peer-reviewed
- Control of directionality of chromatin folding for the inter- and intra-domain contacts at the Tfap2c-Bmp7 locus.Taro Tsujimura; Osamu Takase; Masahiro Yoshikawa; Etsuko Sano; Matsuhiko Hayashi; Tsuyoshi Takato; Atsushi Toyoda; Hideyuki Okano; Keiichi HishikawaEpigenetics & chromatin, 14 Sep. 2018, Peer-reviewed
- Long-term effects of low calcium dialysates on the serum calcium levels during maintenance hemodialysis treatments: A systematic review and meta-analysis.Masahiro Yoshikawa; Osamu Takase; Taro Tsujimura; Etsuko Sano; Matsuhiko Hayashi; Tsuyoshi Takato; Keiichi HishikawaScientific reports, 28 Mar. 2018, Peer-reviewed
- Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases.Taro Tsujimura; Mana Idei; Masahiro Yoshikawa; Osamu Takase; Keiichi HishikawaWorld journal of stem cells, 26 Sep. 2016, Peer-reviewed
- Spatially differentiated expression of quadruplicated green-sensitive RH2 opsin genes in zebrafish is determined by proximal regulatory regions and gene order to the locus control region.Taro Tsujimura; Ryoko Masuda; Ryuichi Ashino; Shoji KawamuraBMC genetics, 04 Nov. 2015, Peer-reviewed
- Adult stem-like cells in kidney.Keiichi Hishikawa; Osamu Takase; Masahiro Yoshikawa; Taro Tsujimura; Masaomi Nangaku; Tsuyoshi TakatoWorld journal of stem cells, 26 Mar. 2015, Peer-reviewed
- A Discrete Transition Zone Organizes the Topological and Regulatory Autonomy of the Adjacent Tfap2c and Bmp7 GenesTaro Tsujimura; Felix A. Klein; Katja Langenfeld; Juliane Glaser; Wolfgang Huber; Francois SpitzPLOS GENETICS, Jan. 2015, Peer-reviewed
- Functional and topological characteristics of mammalian regulatory domains.Orsolya Symmons; Veli Vural Uslu; Taro Tsujimura; Sandra Ruf; Sonya Nassari; Wibke Schwarzer; Laurence Ettwiller; François SpitzGenome research, Mar. 2014, Peer-reviewed
- TRACER: a resource to study the regulatory architecture of the mouse genome.Chao-Kung Chen; Orsolya Symmons; Veli Vural Uslu; Taro Tsujimura; Sandra Ruf; Damian Smedley; François SpitzBMC genomics, 02 Apr. 2013, Peer-reviewed
- Characterization of transgenic zebrafish lines that express GFP in the retina, pineal gland, olfactory bulb, hatching gland, and optic tectumWei Fang; Sarah Bonaffini; Jian Zou; Xiaolei Wang; Cen Zhang; Taro Tsujimura; Shoji Kawamura; Xiangyun WeiGene Expression Patterns, 2013, Peer-reviewed
- Bipolar cell-photoreceptor connectivity in the zebrafish (Danio rerio) retina.Yong N Li; Taro Tsujimura; Shoji Kawamura; John E DowlingThe Journal of comparative neurology, 01 Nov. 2012, Peer-reviewed
- A single enhancer regulating the differential expression of duplicated red-sensitive opsin genes in zebrafish.Taro Tsujimura; Tomohiro Hosoya; Shoji KawamuraPLoS genetics, 16 Dec. 2010, Peer-reviewed
- Regulatory mechanisms for the coordinated expression of duplicated green-sensitive and red-sensitive opsin genes in zebrafish and their evolutionTaro Tsujimura東京大学, Mar. 2008, Peer-reviewed
- Rescue from oculocutaneous albinism type 4 using medaka slc45a2 cDNA driven by its own promoter.Shoji Fukamachi; Masato Kinoshita; Taro Tsujimura; Atsuko Shimada; Shoji Oda; Akihiro Shima; Axel Meyer; Shoji Kawamura; Hiroshi MitaniGenetics, Feb. 2008, Peer-reviewed
- Identification of a locus control region for quadruplicated green-sensitive opsin genes in zebrafish.Taro Tsujimura; Akito Chinen; Shoji KawamuraProceedings of the National Academy of Sciences of the United States of America, 31 Jul. 2007, Peer-reviewed
- Evolutionarily conserved and divergent regulatory sequences in the fish rod opsin promoter.Shoji Kawamura; Kumiko Takeshita; Taro Tsujimura; Satoshi Kasagi; Yoshifumi MatsumotoComparative biochemistry and physiology. Part B, Biochemistry & molecular biology, Aug. 2005, Peer-reviewed
- Evolutionarily conserved and diverged regulatory sequences in fish rod opsin promoterShoji Kawamura; Kumiko Takeshita; Taro Tsujimura; Satoshi Kasagi; Yoshifumi MatsumotoZOOLOGICAL SCIENCE, Dec. 2004, Peer-reviewed
Misc.
- 線維芽由来iPS細胞と腎臓由来iPS細胞における包括的DNAメチル化解析比較からの腎系統特異的分化誘導法の検討高瀬敦; 高瀬敦; 辻村太郎; 辻村太郎; 出射真奈; 出射真奈; 高戸毅; 南学正臣; 菱川慶一; 菱川慶一日本抗加齢医学会総会プログラム・抄録集, Jun. 2016
- 留学のメリットとデメリット辻村太郎UJA留学体験記, May 2015, Peer-reviewed, Invited
- A single region regulates duplicated red-sensitive opsin genes in zebrafishRyuichi Ashino; Taro Tsujimura; Tomohiro Hosoya; Shoji KawamuraGENES & GENETIC SYSTEMS, Dec. 2011
- The regulatory mechanism of zebrafish green-sensitive opsin genes as a model study of collective regulation of tandemly duplicated opsin genesTaro Tsujimura; Shoji KawamuraGENES & GENETIC SYSTEMS, Dec. 2006
- Identification of a LCR-like distal regulatory region for multiple green-sensitive opsin genes in zebrafishTaro Tsujimura; Akito Chinen; Shoji KawamuraZOOLOGICAL SCIENCE, Dec. 2005
Presentations
- ロングリード解析を利用した、遺伝子とエンハンサーの相互作用研究辻村太郎Oxford Nanopore Technologies ナノポアデー大阪 2023, 22 Jun. 2023, Invited
- エンハンサー相互作用の調節により生まれる多様なゲノム制御辻村太郎第16回日本エピジェネティクス研究会年会, 19 Jun. 2023, Invited
- PacBio HiFiリードによるシングルセルアイソフォーム解析辻村太郎PacBioロードショー2023, 17 May 2023, Invited
- 多層的な長距離エンハンサー制御：メカニズムの研究とその応用辻村太郎最先端循環代謝学の若手研究会（第4回）, 12 Dec. 2022, Invited
- データ解析概要 ～scRNA-seqドライ解析の基礎～辻村太郎先端バイオメディシン解析技術室テクニカルセミナーシリーズ scRNA-seq解析セミナー, 21 Sep. 2022, Invited
- 遺伝子とエンハンサーの相互作用を理解する：新技術によるアプローチ辻村太郎第45回日本分子生物学会年会, 30 Nov. 2022, Invited
- ロングリード解析を活用した長距離ゲノム調節機構の研究辻村太郎NGS EXPO 2022, 19 Oct. 2022, Invited
- Modulating enhancer regulation: mechanisms and applicationsTaro TsujimuraRIKEN IMS Seminar: Mini workshop on Chromatin Regulation, 27 May 2021, Invited
- Regulation of gene activation by long-range enhancersTaro Tsujimura1st ASHBi SignAC Workshop, 19 Feb. 2021, Invited
- 生命科学研究（ゲノム機能解析研究）の データマネジメント辻村太郎第4回京都大学研究データマネジメントワークショップ、セッション2 「科研費プロジェクト『葛桜』」, 19 Sep. 2020, Invited
- Controlling gene activation by enhancers through a drug-inducible topological insulatorTaro TsujimuraASHBi Young Researcher Meeting, 11 Dec. 2019, Invited
- クロマチン高次構造から考える遺伝子制御の制約と可塑性辻村太郎第 20 回日本進化学会大会 シンポジウム『表現型の可塑性~ホモ・サピエンスの環境適応のヒントを探る』, 24 Aug. 2018, Invited
- クロマチンの基本高次構造が織りなす多様な遺伝子転写制御機構辻村太郎国立成育医療研究セン ター特別セミナー, 03 Aug. 2018
- クロマチン構造と遺伝子発現 - 疾患研究への応用を見据えて辻村太郎東京大学医学部附属病院第６０回再生医療カンファレンス, 21 Apr. 2016, Invited
- 腎臓発生におけるBmp7の特異的発現を制御するクロマチン高次構造辻村太郎第45回 日本腎臓学会東部学術大会「よくわかるシリーズ」, 02 Oct. 2015, Invited
- Enhancer allocation and chromatin conformation: topological and regulatory autonomy of the adjacent Tfap2c and Bmp7 genes in miceTaro TsujimuraInvited Seminar at NIBB, 20 Feb. 2015, Invited
- クロマチンの高次構造とエンハンサーの標的制御辻村太郎東京大学大学院農学生命科学研究科応用動物科学専攻「ゲノムと生体情報の科学」集中講義, 26 Jan. 2015, Invited
- Enhancer allocation and chromatin conformation: topological and regulatory autonomy of the adjacent Tfap2c and Bmp7 genes in miceTaro TsujimuraInvited Seminar at Laboratory of Developmental Genetics, RIKEN Center for Integrative Medical Science, 23 Jan. 2015, Invited
- ゲノム高次構造とエンハンサーの標的制御: 隣接遺伝子群Tfap2c-Bmp7の分断と統括辻村太郎東京大学先端科学技術センター臨床エピジェネティクス講座招待講演, 07 Jul. 2014, Invited
- Serial Genomic Rearrangements Revealed Local- and Global-Regulatory Architecture of the Adjacent Developmental Genes Bmp7 and Ap2γ辻村太郎大阪大学大学院医学研究科環境・生体機能学セミナー, 08 Mar. 2013, Invited
- Serial Genomic Rearrangements Revealed Local- and Global-Regulatory Architecture of the Adjacent Developmental Genes Bmp7 and Ap2γTaro TsujimuraSeminar at National Institute of Genetics, Mishima, 07 Mar. 2013, Invited
Books and Other Publications
- 実験デザインからわかるシングルセル研究実践テキスト大倉, 永也; 渡辺, 亮; 鈴木, 穣 (ゲノム医科学), Contributor, 第12章 解析結果の検証，解釈「三次元オルガノイドモデルアクシオロイドの特性評価」羊土社, Apr. 2024
Industrial Property Rights
- 特願2018-154577, PCT/JP2019/032106, Enhancer blocker and use thereofTaro Tsujimura; Hideyuki Okano; Keiichi Hishikawa
External funds: Kakenhi
- Understanding enhancer allocation by 3D genome "domains" through analysis of two parameters in the regulation.Grant-in-Aid for Scientific Research (C)Basic Section 43050:Genome biology-relatedKyoto UniversityTaro TsujimuraFrom 01 Apr. 2020, To 31 Mar. 2023, Project Closedゲノム;エンハンサー;相互作用;クロマチン高次構造;遺伝子発現;CTCF;ゲノム編集;STITCH;数理モデル
- Functional analysis of enhancers to dissect differential roles of BMP7 secreted from distinct sites in kidney.Grant-in-Aid for Young Scientists (B)Kyoto University;Keio UniversityTaro TsujimuraFrom 01 Apr. 2017, To 31 Mar. 2020, Project Closedエンハンサー;BMP7;腎臓;CTCF;Bmp7;シングルセルRNA-seq;クロマチン高次構造;腎機能;遺伝子;クロマチン;マウス;ゲノム編集
- Identification of novel renal lineage differentiative induction by genome wide methylation analysis of human kidney-derived iPS cellsGrant-in-Aid for Scientific Research (C)Keio University;The University of TokyoOSAMU TAKASEFrom 01 Apr. 2016, To 31 Mar. 2019, Project ClosedEpigenetic memory;Methylation;iPS細胞;腎上皮細胞由来iPS細胞;新規腎系統分化誘導因子;癌幹細胞;リプログラミング;エピジェネティクス;DNAの脱メチル化剤;腎臓がん由来iPS細胞;腎臓由来iPS細胞;DNAメチル化解析;DNA マイクロアレイ解析;腎系統分化誘導遺伝子;腎臓細胞記憶;Epigenetic Memory;腎系統分化誘導法;腎臓分化誘導因子;ヒト腎臓由来iPS細胞;エピゲジェネティクス;DNAメチル化;マイクロアレイ;CRISPR
- Beyond allocating enhancers: Deciphering diverse roles of the ground-state chromatin conformation in gene regulation.Grant-in-Aid for Young Scientists (B)The University of TokyoTaro TsujimuraFrom 01 Apr. 2015, To 31 Mar. 2017, Project Closedゲノム;エンハンサー;クロマチン高次構造;マウス;ゲノム編集;片アリル欠失ES細胞;腎系統分化誘導
- Population genomics of Jomon: elucidating adaptive evolution in ancient hunters and gatherers and its legacy in modern populationsGrant-in-Aid for Scientific Research (B)Basic Section 45060:Applied anthropology-relatedKanazawa University中込 滋樹From 01 Apr. 2022, To 31 Mar. 2025, Grantedパレオゲノミクス;狩猟採集民;自然選択;集団遺伝学;環境適応
- Population genomics of Jomon: elucidating adaptive evolution in ancient hunters and gatherers and its legacy in modern populationsGrant-in-Aid for Scientific Research (B)Basic Section 45060:Applied anthropology-relatedKanazawa University中込 滋樹From 01 Apr. 2022, To 31 Mar. 2025, Grantedパレオゲノミクス;狩猟採集民;集団遺伝学;自然選択;環境適応
External funds: others
list
Last Updated :2025/05/02
Academic, Social Contribution
Academic Contribution
- The 3rd ASHBi SignAC WorkshopPlanning, management, etc., Panel moderatorTaro Tsujimura, Takuya Yamamoto, Mitinori Saitou, From 15 May 2024, To 15 May 2024
- 第４５回日本分子生物学会年会ワークショップ「多様な機能性制御領域が織りなすゲノムオートノミー：新技術と最前線」Planning, management, etc., Panel moderator, Peer review井上 詞貴、辻村 太郎, From 30 Nov. 2022, To 30 Nov. 2022
- The 2nd ASHBi SignAC WorkshopPlanning, management, etc., Panel moderatorFrom 10 Dec. 2021, To 10 Dec. 2021
- The 1st ASHBi SignAC WorkshopPlanning, management, etc.From 19 Feb. 2021, To 19 Feb. 2021
