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Nakagawa, Naoki
Graduate School of Medicine, Department of Human Health Sciences Associate Professor
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Last Updated :2025/07/24
Basic Information
Faculty
Email Address
Email Address
nakagawa.naoki.3z
kyoto-u.ac.jp
Academic Degree
Academic Resume (Undergraduate School/Majors)
Research History
- From Oct. 2024, To PresentHuman Health Sciences, Graduate School of Medicine, Kyoto University, 准教授
- From Sep. 2018, To Sep. 2024National Institute of Genetics, 助教
- From Apr. 2015, To Aug. 2018ノースカロライナ大学, 博士研究員
- From Apr. 2013, To Mar. 2015日本学術振興会 特別研究員
Profile
Profile
大脳皮質における、神経細胞層の構築と神経回路網の形成を担う分子・細胞メカニズムに興味を持って研究を行っています。
ID,URL
ORCID ID
J-Global ID
Researcher number
30835426
researchmap URL
list
Last Updated :2025/07/24
Research
Research Interests
Research Areas
Papers
- The neuronal Golgi in neural circuit formation and reorganizationNaoki NakagawaFrontiers in Neural Circuits, 05 Dec. 2024, Peer-reviewed, Lead author, Corresponding author
- Activity-dependent dendrite patterning in the postnatal barrel cortexNaoki Nakagawa; Takuji IwasatoFrontiers in Neural Circuits, 17 May 2024, Peer-reviewed, Lead author, Corresponding author
- Golgi polarity shift instructs dendritic refinement in the neonatal cortex by mediating NMDA receptor signaling.Naoki Nakagawa; Takuji IwasatoCell reports, 26 Jul. 2023, Peer-reviewed, Lead author, Corresponding author
- Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.Nakagawa N; Plestant C; Yabuno-Nakagawa K; Li J; Lee J; Huang CW; Lee A; Krupa O; Adhikari A; Thompson S; Rhynes T; Arevalo V; Stein JL; Molnár Z; Badache A; Anton ESNeuron, Sep. 2019, Peer-reviewed, Lead author, Corresponding author
- APC sets the Wnt tone necessary for cerebral cortical progenitor developmentNaoki Nakagawa; Jingjun Li; Keiko Yabuno-Nakagawa; Tae-Yeon Eom; Martis Cowles; Tavien Mapp; Robin Taylor; E. S. AntonGENES & DEVELOPMENT, Aug. 2017, Peer-reviewed, Lead author
- Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial GliaMarco Onorati; Zhen Li; Fuchen Liu; Andre M. M. Sousa; Naoki Nakagawa; Mingfeng Li; Maria Teresa Dell'Anno; Forrest O. Gulden; Sirisha Pochareddy; Andrew T. N. Tebbenkamp; Wenqi Han; Mihovil Pletikos; Tianliuyun Gao; Ying Zhu; Candace Bichsel; Luis Varela; Klara Szigeti-Buck; Steven Lisgo; Yalan Zhang; Anze Testen; Xiao-Bing Gao; Jernej Mlakar; Mara Popovic; Marie Flamand; Stephen M. Strittmatter; Leonard K. Kaczmarek; E. S. Anton; Tamas L. Horvath; Brett D. Lindenbach; Nenad SestanCELL REPORTS, Sep. 2016, Peer-reviewed
- [Dystroglycan glycosylation: structure, synthetic pathway, and in vivo role in the brain development].Naoki Nakagawa; Shogo OkaSeikagaku. The Journal of Japanese Biochemical Society, Aug. 2016, Peer-reviewed, Lead author
- Ectopic clustering of Cajal-Retzius and subplate cells is an initial pathological feature in Pomgnt2-knockout mice, a model of dystroglycanopathy.Naoki Nakagawa; Hirokazu Yagi; Koichi Kato; Hiromu Takematsu; Shogo OkaScientific reports, 10 Jun. 2015, Peer-reviewed, Lead author
- Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTP betaShohei Yaji; Hiroshi Manya; Naoki Nakagawa; Hiromu Takematsu; Tamao Endo; Reiji Kannagi; Toru Yoshihara; Masahide Asano; Shogo OkaGLYCOBIOLOGY, Apr. 2015, Peer-reviewed
- HNK-1 Glyco-Epitope: Complex machinery for biosynthesisNaoki Nakagawa; Shogo OkaGlycoscience: Biology and Medicine, 01 Jan. 2015, Peer-reviewed, Lead author
- AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.Hirokazu Yagi; Naoki Nakagawa; Takuya Saito; Hiroshi Kiyonari; Takaya Abe; Tatsushi Toda; Sz-Wei Wu; Kay-Hooi Khoo; Shogo Oka; Koichi KatoScientific reports, 21 Nov. 2013, Peer-reviewed, Lead author
- HNK-1 sulfotransferase-dependent sulfation regulating laminin-binding glycans occurs in the post-phosphoryl moiety on alpha-dystroglycanNaoki Nakagawa; Hiromu Takematsu; Shogo OkaGLYCOBIOLOGY, Sep. 2013, Peer-reviewed, Lead author
- Human Natural Killer-1 Sulfotransferase (HNK-1ST)-induced Sulfate Transfer Regulates Laminin-binding Glycans on alpha-DystroglycanNaoki Nakagawa; Hiroshi Manya; Tatsushi Toda; Tamao Endo; Shogo OkaJOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2012, Peer-reviewed, Lead author
- Sulfation of glucuronic acid in the linkage tetrasaccharide by HNK-1 sulfotransferase is an inhibitory signal for the expression of a chondroitin sulfate chain on thrombomodulinNaoki Nakagawa; Tomomi Izumikawa; Hiroshi Kitagawa; Shogo OkaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2011, Peer-reviewed, Lead author
- Specific Enzyme Complex of beta-1,4-Galactosyltransferase-II and Glucuronyltransferase-P Facilitates Biosynthesis of N-linked Human Natural Killer-1 (HNK-1) CarbohydrateTetsuya Kouno; Yasuhiko Kizuka; Naoki Nakagawa; Toru Yoshihara; Masahide Asano; Shogo OkaJOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Peer-reviewed
Misc.
- POMGNT1とB3GALNT2は協同的にalpha-ジストログリカン上の部位特異的なリガンド結合糖鎖の発現を制御する東 良柄; 中川 直樹; 竹松 弘; 岡 昌吾日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015
- Molecular mechanisms underlying the formation of laminin-binding glycans displayed on alpha-dystroglycanHirokazu Yagi; Naoki Nakagawa; Shogo Oka; Koichi KatoGLYCOBIOLOGY, Nov. 2014
- Requirement of acidic amino acids in the glucuronyltransferase-P (GlcAT-P) flexible loop for its enzyme activityYasuhiko Kizuka; Naoki Nakagawa; Ippei Morita; Shogo OkaGlycans: Biochemistry, Characterization and Applications, 01 Feb. 2012
Presentations
- 神経回路再編成を駆動する生後発達期神経細胞のゴルジ体極性シフト中川直樹第4回 日本神経化学会 若手KYOUEN, 15 Feb. 2025, Invited
- Golgi polarity shift instructs neuronal circuit reorganization in the neonatal cerebral cortex中川直樹第47回日本神経科学大会, 26 Jul. 2024, Invited
- 神経回路再編成を制御する生後発達期神経細胞のゴルジ体極性シフト中川直樹第76回日本細胞生物学会大会, 17 Jul. 2024, Invited
- Golgi polarity shift instructs thalamocortical module formation in the neonatal barrel cortexNaoki Nakagawa第38回熊本医学・生物科学国際シンポジウム 「機能的脳神経回路システムの構築メカニズム」, 14 Dec. 2023, Invited
- Golgi apparatus polarity shift facilitates dendritic refinement in the neonatal barrel cortexNaoki Nakagawa; Takuji IwasatoDevelopment and Plasticity of the Brain, 21 Oct. 2022, Invited
- 活動依存的なゴルジ体局在変化による大脳皮質神経細胞の樹状突起精緻化中川直樹; 岩里琢治第45回日本神経科学大会, 02 Jul. 2022
- ゴルジ体ダイナミクスによる大脳皮質神経細胞の樹状突起精緻化中川直樹第14回 神経発生討論会, 19 Mar. 2021
- Spatial remodeling and organelle dynamics of L4 neurons during thalamocortical module formation in the mouse barrel cortex中川直樹遺伝研研究会「哺乳類脳の機能的神経回路の構築メカニズム」, 12 Dec. 2020, 山本亘彦、河崎洋志、田川義晃、中川直樹、岩里琢治, Invited
- MEMO1 mediates the tiling of radial glial cells essential for the neocortical layer formation中川直樹遺伝研研究会「哺乳類脳の機能的神経回路の構築メカニズム」, 21 Dec. 2018
Awards
External funds: Kakenhi
- 大脳皮質カラムの反応特異性を成立させる発達期の細胞内メカニズム解明Grant-in-Aid for Scientific Research (B)Basic Section 46010:Neuroscience-general-relatedNational Institute of Genetics中川 直樹From 01 Apr. 2024, To 31 Mar. 2027, Granted大脳皮質カラム;神経回路形成;樹状突起;バレル皮質;生後脳発達
- 分化状態と遺伝子発現の多重プロファイリングによる適応回路構築機構の解読Grant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)Kyoto University;National Institute of Genetics中川 直樹From 01 Apr. 2024, To 31 Mar. 2026, Granted神経回路再編;分化不均一性;シングルセルRNA-seq;バレル皮質;生後発達
- ゴルジ体局在動態から紐解く発達期の臨界期回路再編メカニズムGrant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)National Institute of Genetics中川 直樹From 01 Apr. 2023, To 31 Mar. 2025, Granted臨界期;大脳皮質神経回路;樹状突起精緻化;ゴルジ体;細胞極性
- 分化状態の細胞間格差プロファイリングによる適応回路構築機構の解読Grant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)National Institute of Genetics中川 直樹From 16 Jun. 2022, To 31 Mar. 2024, Granted神経回路再編;分化不均一性;シングルセルRNA-seq;バレル皮質;生後発達
- Visualization of cortical module formation by longitudinal in vivo neuron trackingGrant-in-Aid for Early-Career ScientistsBasic Section 46020:Anatomy and histopathology of nervous system-relatedNational Institute of GeneticsNaoki NakagawaFrom 01 Apr. 2021, To 31 Mar. 2024, Project Closed大脳皮質;神経回路形成;in vivoイメージング;バレル皮質;単一細胞動態追跡
- オルガネラ動態から紐解く発達期の臨界期回路再編メカニズムGrant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)National Institute of Genetics中川 直樹From 10 Sep. 2021, To 31 Mar. 2023, Project Closed大脳皮質神経回路;臨界期;ゴルジ体;樹状突起精緻化;in vivoイメージング
- Visualization of the spatial remodeling of cortical neurons during postnatal module formationGrant-in-Aid for Early-Career ScientistsBasic Section 46020:Anatomy and histopathology of nervous system-relatedNational Institute of GeneticsNaoki NakagawaFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closed神経科学;神経回路形成;生体イメージング;単一細胞動態追跡;バレル皮質
list
Last Updated :2025/07/24
Education
Teaching subject(s)
- From 01 Apr. 2025, To 31 Mar. 2026Fundamental Chemical ExperimentsN308, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Molecular cell biology training8010, Fall, Faculty of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Biochemistry and Neutrition3221, Spring, Faculty of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Seminar of Molecular Basic Medical ScienceM427, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Lecture of Molecular Basic Medical ScienceM426, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Molecule cellular biology8009, Fall, Faculty of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Methods in Molecular Basic Medical ScienceM428, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Seminar of Molecular Basic Medical ScienceD426, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Lecture of Molecular Basic Medical ScienceD425, Year-long, Graduate School of Medicine, 4
