Basic Information

Faculty

• 医学部

Professional Memberships

• 日本分子生物学会
• 日本RNA学会
• 日本免疫学会

Academic Degree

• 博士（医学）(京都大学)

Research History

• From Oct. 2024, To Present

  Kyoto University, FOREST Principle Investigator
• From Apr. 2020, To Present

  京都大学大学院医学研究科 医化学分野, 助教

ID,URL

• J-Global ID

  202001003586169020

researchmap URL

• https://researchmap.jp/m_yoshi

Research

Research Areas

• Life sciences, Nutrition and health science
• Life sciences, Molecular biology
• Life sciences, Immunology
• Life sciences, Medical biochemistry

Papers

• UPF1 plays critical roles in early B cell development.

  Noriki Iwai; Kotaro Akaki; Fabian Hia; Wei Li; Masanori Yoshinaga; Takashi Mino; Osamu Takeuchi

  Nature communications, 09 Jul. 2024, Peer-reviewed

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• Regulation of inflammatory diseases via the control of mRNA decay.

  Masanori Yoshinaga; Osamu Takeuchi

  Inflammation and regeneration, 15 Mar. 2024, Peer-reviewed, Invited, Lead author, Corresponding author

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• RNA Metabolism Governs Immune Function and Response.

  Masanori Yoshinaga; Osamu Takeuchi

  Advances in experimental medicine and biology, 2024, Invited, Lead author

  
• The crossroads of RNA methylation and ferroptosis: Implications for disease pathogenesis

  Masanori Yoshinaga

  Clinical and Translational Discovery, 07 Nov. 2023, Corresponding author

  
• The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity.

  Masanori Yoshinaga; Kyuho Han; David W Morgens; Takuro Horii; Ryosuke Kobayashi; Tatsuaki Tsuruyama; Fabian Hia; Shota Yasukura; Asako Kajiya; Ting Cai; Pedro H C Cruz; Alexis Vandenbon; Yutaka Suzuki; Yukio Kawahara; Izuho Hatada; Michael C Bassik; Osamu Takeuchi

  Nature communications, 28 Oct. 2022, Peer-reviewed, Lead author, Corresponding author

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• Regnase-1 Prevents Pulmonary Arterial Hypertension Through mRNA Degradation of Interleukin-6 and Platelet-Derived Growth Factor in Alveolar Macrophages.

  Ai Yaku; Tadakatsu Inagaki; Ryotaro Asano; Makoto Okazawa; Hiroyoshi Mori; Ayuko Sato; Fabian Hia; Takeshi Masaki; Yusuke Manabe; Tomohiko Ishibashi; Alexis Vandenbon; Yoshinari Nakatsuka; Kotaro Akaki; Masanori Yoshinaga; Takuya Uehata; Takashi Mino; Satoshi Morita; Hatsue Ishibashi-Ueda; Akio Morinobu; Tohru Tsujimura; Takeshi Ogo; Yoshikazu Nakaoka; Osamu Takeuchi

  Circulation, 23 Aug. 2022, Peer-reviewed

  
• Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases.

  Ka Man Tse; Alexis Vandenbon; Xiaotong Cui; Takashi Mino; Takuya Uehata; Keiko Yasuda; Ayuko Sato; Tohru Tsujimura; Fabian Hia; Masanori Yoshinaga; Makoto Kinoshita; Tatsusada Okuno; Osamu Takeuchi

  Science translational medicine, 11 May 2022, Peer-reviewed

  
• Cyclin J-CDK complexes limit innate immune responses by reducing proinflammatory changes in macrophage metabolism.

  Yee Kien Chong; Sarang Tartey; Yuki Yoshikawa; Koshi Imami; Songling Li; Masanori Yoshinaga; Ai Hirabayashi; Guohao Liu; Alexis Vandenbon; Fabian Hia; Takuya Uehata; Takashi Mino; Yutaka Suzuki; Takeshi Noda; Dominique Ferrandon; Daron M Standley; Yasushi Ishihama; Osamu Takeuchi

  Science signaling, 12 Apr. 2022, Peer-reviewed

  
• TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregation.

  Atsuko Wakabayashi; Masanori Yoshinaga; Osamu Takeuchi

  Life science alliance, Feb. 2022, Peer-reviewed

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• Profibrotic function of pulmonary group 2 innate lymphoid cells is controlled by Regnase-1.

  Yoshinari Nakatsuka; Ai Yaku; Tomohiro Handa; Alexis Vandenbon; Yuki Hikichi; Yasutaka Motomura; Ayuko Sato; Masanori Yoshinaga; Kiminobu Tanizawa; Kizuku Watanabe; Toyohiro Hirai; Kazuo Chin; Yutaka Suzuki; Takuya Uehata; Takashi Mino; Tohru Tsujimura; Kazuyo Moro; Osamu Takeuchi

  The European respiratory journal, 25 Sep. 2020, Peer-reviewed

  
• Codon bias confers stability to human mRNAs.

  Fabian Hia; Sheng Fan Yang; Yuichi Shichino; Masanori Yoshinaga; Yasuhiro Murakawa; Alexis Vandenbon; Akira Fukao; Toshinobu Fujiwara; Markus Landthaler; Tohru Natsume; Shungo Adachi; Shintaro Iwasaki; Osamu Takeuchi

  EMBO reports, 05 Nov. 2019, Peer-reviewed

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• RNA binding proteins in the control of autoimmune diseases.

  Masanori Yoshinaga; Osamu Takeuchi

  Immunological medicine, Jun. 2019, Peer-reviewed, Lead author

  
• Post-transcriptional control of immune responses and its potential application.

  Masanori Yoshinaga; Osamu Takeuchi

  Clinical & translational immunology, 2019, Peer-reviewed, Lead author

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• Pulmonary Regnase-1 orchestrates the interplay of epithelium and adaptive immune systems to protect against pneumonia.

  Yoshinari Nakatsuka; Alexis Vandenbon; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Xiaotong Cui; Ayuko Sato; Tohru Tsujimura; Yutaka Suzuki; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Teiji Sawa; Toyohiro Hirai; Osamu Takeuchi

  Mucosal immunology, Jul. 2018, Peer-reviewed

  
• Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.

  Xiaotong Cui; Takashi Mino; Masanori Yoshinaga; Yoshinari Nakatsuka; Fabian Hia; Daichi Yamasoba; Tohru Tsujimura; Keizo Tomonaga; Yutaka Suzuki; Takuya Uehata; Osamu Takeuchi

  Journal of immunology (Baltimore, Md. : 1950), 15 Dec. 2017, Peer-reviewed

  
• Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.

  Masanori Yoshinaga; Yoshinari Nakatsuka; Alexis Vandenbon; Daisuke Ori; Takuya Uehata; Tohru Tsujimura; Yutaka Suzuki; Takashi Mino; Osamu Takeuchi

  Cell reports, 23 May 2017, Peer-reviewed, Lead author

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• Moesin controls clathrin-mediated S1PR1 internalization in T cells.

  Akira Nomachi; Masanori Yoshinaga; Jaron Liu; Pakorn Kanchanawong; Kiyoshi Tohyama; Dean Thumkeo; Takeshi Watanabe; Shuh Narumiya; Takako Hirata

  PloS one, 2013, Peer-reviewed

  

Misc.

• 自己指向性免疫学の新展開 生体防御における自己認識の功罪(Vol.8) RNA修飾破綻による自己指向性免疫応答

  吉永 正憲

  医学のあゆみ, Aug. 2024, Invited, Last author, Corresponding author

  
• RNA修飾が織りなす免疫制御メカニズム

  吉永正憲

  臨床免疫・アレルギー科, Oct. 2023, Invited, Lead author, Corresponding author

  
• 免疫学 RNA分解酵素Regnase-1を標的とした炎症制御法の開発

  吉永 正憲; 竹内 理

  医学のあゆみ, Jan. 2023

  
• がん免疫療法における免疫チェックポイント機構とマクロファージのはたらき

  吉永正憲; 竹内理

  Trends in Cancer Immunology, 2020

  
• Identification of a novel post-transcriptional regulator in erythroid differentiation

  吉永正憲; 竹内理

  日本分子生物学会年会プログラム・要旨集(Web), 2021

  
• 鉄代謝を制御する転写後調節機構の解明

  吉永正憲; 三野享史; BASSIK Michael C; 竹内理

  日本RNA学会年会要旨集, 2018

  
• Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

  吉永正憲; 三野享史; 竹内理

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• RNA分解酵素Regnase-1による鉄代謝制御機構

  竹内理; 吉永正憲

  日本鉄バイオサイエンス学会学術集会プログラム・抄録集, 2018

  
• Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

  吉永正憲; 三野享史; 竹内理

  日本生化学会大会(Web), 2017

  
• Regnase-1は鉄代謝関連のmRNAを分解することで鉄恒常性を維持する

  吉永正憲; 三野享史; 竹内理

  日本RNA学会年会要旨集, 2017

  
• 生理学・医学賞 免疫を抑制する分子"PD-1"とがん免疫療法 (2018年ノーベル賞を読み解く)

  吉永 正憲; 竹内 理

  化学 = Chemistry, Dec. 2018

  
• 【がんは免疫系をいかに抑制するのか 免疫チェックポイント阻害剤の真の標的を求めて】TAM・MDSCによる免疫抑制機構

  吉永 正憲; 竹内 理

  実験医学, Jun. 2018

  
• 生化学・分子生物学 RNA分解酵素Regnase-1による鉄代謝制御

  吉永 正憲; 竹内 理

  医学のあゆみ, Apr. 2018

  
• Pulmonary Regnase-1 functions as a posttranscriptional switch in anti-bacterial immunity

  Yoshinari Nakatsuka; Takashi Mino; Masanori Yoshinaga; Takuya Uehata; Atsuyasu Sato; Tomohiro Handa; Kazuo Chin; Toyohiro Hirai Hirai; Osamu Takeuchi

  CYTOKINE, Dec. 2017

  
• 【慢性炎症性疾患の新たな展開】慢性炎症のメカニズム 慢性炎症における炎症性サイトカインの新たな制御機構

  吉永 正憲; 竹内 理

  最新医学, Nov. 2016

  
• 【マクロファージのすべて】基礎 炎症性サイトカインIL-6とその転写後調節

  吉永 正憲; 竹内 理

  医学のあゆみ, Oct. 2016

  
• 炎症制御の分子機構

  吉永 正憲; 竹内 理

  臨床免疫・アレルギー科, Oct. 2015

  

Presentations

• TBA

  Masanori Yoshinaga

  RIBOSOME Meeting 2024 in JAPAN, Dec. 2024, Invited

  
• 転写後調節を介した鉄代謝・赤血球造血制御

  吉永正憲

  第48回日本鉄バイオサイエンス学会学術集会, 30 Aug. 2024, Invited

  
• mRNAの制御破綻による自己指向性免疫応答の解明

  吉永正憲

  学術変革領域研究（A）自己指向性免疫学 第64回オンラインJournal Club, 03 Jul. 2024, Invited

  
• RNAに対する自己指向性免疫応答の解明

  吉永正憲

  学術変革領域研究（A）自己指向性免疫学 令和6年度領域会議, 13 Jun. 2024, Invited

  
• RNAメチル化修飾を介した細胞機能の調節

  吉永正憲

  The 3rd Kansai RNA Club, 25 Mar. 2024, Invited

  
• Unraveling metabolic reprogramming of macrophages through the lens of evolutionary and forward genetics

  Masanori Yoshinaga

  International Symposium on Emerging RNA Viruses, 07 Dec. 2023, Invited

  
• Regulation of hematopoietic cell differentiation and functions by RNA methylation

  Masanori Yoshinaga

  第101回日本生理学会大会, 30 Mar. 2024, Invited

  
• 転写後調節を介した造血・代謝制御機構

  吉永正憲

  群馬大学生体調節研究所 内分泌・代謝学共同研究拠点成果報告会・ワークショップ, 15 Dec. 2023, Invited

  
• mRNAの制御破綻による自己指向性免疫応答の解明

  吉永正憲

  学術変革領域研究（A）自己指向性免疫学 第28回オンラインJournal Club, 13 Sep. 2023, Invited

  
• 転写後調節を介した赤血球造血制御機構の解明

  吉永正憲

  第18回血液学若手研究者勉強会(麒麟塾), 01 Jul. 2023, Invited

  
• RNAメチル化修飾破綻による自己指向性免疫応答の解明

  吉永正憲

  学術変革領域研究（A）自己指向性免疫学 令和 5 年度領域会議, 09 May 2023, Invited

  
• Identification of post-transcriptional regulators in iron metabolism and erythropoiesis

  Masanori Yoshinaga

  The 2nd Course Meeting of Immunology, Allergy, and Infection Course 2020, 10 Jun. 2020, Invited

  
• Identification of posttranscriptional regulators in iron metabolism

  Masanori Yoshinaga

  第20回日本RNA学会年会, 09 Jul. 2018, Invited

  
• The ribonuclease Regnase-1 maintains iron homeostasis by regulating duodenal iron uptake

  Masanori Yoshinaga

  The 9th Course Meeting of Immunology, Allergy, and Infection Course 2016, 08 Feb. 2017, Invited

  

External funds: Kakenhi

• RNA修飾を介した赤芽球分化制御機構の解明

  Grant-in-Aid for Early-Career Scientists

  Basic Section 49010:Pathological biochemistry-related

  Kyoto University

  吉永 正憲

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  RNA修飾;赤芽球分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15372/
• Posttranscriptional regulation of iron metabolism via RNA methylation

  Grant-in-Aid for Research Activity Start-up

  0802:Biomedical structure and function and related fields

  Kyoto University

  Masanori Yoshinaga

  From 11 Sep. 2020, To 31 Mar. 2022, Project Closed

  RNA修飾;鉄代謝;赤芽球分化;CRISPRスクリーニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K22737/
• RNAメチル化修飾破綻による自己指向性免疫応答の解明

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  吉永 正憲

  From 01 Apr. 2023, To 31 Mar. 2025, Granted

  RNA修飾;炎症制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23H04777/
• アミノ酸代謝が司る代謝リプログラミング機構の解明

  Grant-in-Aid for Early-Career Scientists

  Basic Section 59040:Nutrition science and health science-related

  Kyoto University

  吉永 正憲

  From 01 Apr. 2024, To 31 Mar. 2026, Granted

  炎症制御;代謝制御;マクロファージ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K20704/