Begum, Nasim-ara(Graduate School of Medicine) | Activity Database on Education and Research, Kyoto University

Begum, Nasim-ara

Graduate School of Medicine Program-Specific Associate Professor

Last Updated :2025/05/27

Basic Information

Academic Degree

Ｍ．Ｓ．(ビスババラチ大学)

Ｐｈ．Ｄ．(ジャダプール大学)

Research History

Kyoto University, Graduate School of Medicine,, Department of Immunology and Genomic Medicine, Associate Professor

Kyoto University,Graduate School of Medicine,, Department of Immunology and Genomic Medicine, Assistant Professor

Indian Institute of Chemical Biology, Calcutta, India, Department of Biophysics, Scientist

ID,URL

J-Global ID
201401007771167341

researchmap URL

https://researchmap.jp/7000008861

Last Updated :2025/05/27

Research

Research Interests

Antibody Class Switch Recombination

Epigenomic Regulation

Genomic Instability

Research Areas

Life sciences, Immunology

Life sciences, Molecular biology

Papers

Mycobacterium bovis Bacillus Calmette-Guerin and Its Cell Wall Complex Induce a Novel Lysosomal Membrane Protein, SIMPLE, that Bridges the Missing Link between Lipopolysaccharide and p53-inducible Gene, LITAF(PIG7), and Estrogen-inducible Gene, EET-1
Yasuhiro Moriwaki; Nasim A. Begum; Mika Kobayashi; Misako Matsumoto; Kumao Toyoshima; Tsukasa Seya
Journal of Biological Chemistry, 22 Jun. 2001

High serum levels of additional IL-18 forms may be reciprocally correlated with IgE levels in patients with atopic dermatitis
Kyoko Shida; Hiroko Koizumi; Ikuo Shiratori; Misako Matsumoto; Satomi Kikkawa; Shoutaro Tsuji; Nasim A. Begum; Yasuo Fukumori; Kumao Toyoshima; Tsukasa Seya
Immunology Letters, 03 Dec. 2001

A comparative analysis of the antigenic, structural, and functional properties of three different preparations of recombinant human interleukin- 18
Satomi Kikkawa; Kyoko Shida; Haruki Okamura; Nasim A. Begum; Misako Matsumoto; Shoutaro Tsuji; Midori Nomura; Yasuhiko Suzuki; Kumao Toyoshima; Tsukasa Seya
Journal of Interferon and Cytokine Research, 2000

Human MD-1 homologue is a BCG-regulated gene product in monocytes: Its identification by differential display
Nasim A. Begum; Shoutaro Tsuji; Midori Nomura; Kyoko Shida; Ichiro Azuma; Akira Hayashi; Misako Matsumoto; Tsukasa Seya; Kumao Toyoshima
Biochemical and Biophysical Research Communications, 16 Mar. 1999

Two receptor theory in innate immune activation: Studies on the receptors for bacillus culmet guillen-cell wall skeleton
Tsukasa Seya; Misako Matsumoto; Shoutaro Tsuji; Nasim A. Begum; Midori Nomura; Ichiro Azuma; Akira Hayashi; Kumao Toyoshima
Archivum Immunologiae et Therapiae Experimentalis, 2001

BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL
Santosh K Gothwal; Ahmed M Refaat; Mikiyo Nakata; Andre Stanlie; Tasuku Honjo; Nasim A Begum
Nucleic Acids Research, 03 Apr. 2024

HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
Ahmed M. Refaat; Mikiyo Nakata; Afzal Husain; Hidetaka Kosako; Tasuku Honjo; Nasim A. Begum
Cell Reports, Mar. 2023
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Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory
Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Nasim A. Begum; Tasuku Honjo
Advances in Immunology, 2007, Peer-reviewed

Regulation of AID Function In Vivo
Reiko Shinkura; Il-mi Okazaki; Taro Muto; Nasim A. Begum; Tasuku Honjo
MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION XI: B CELL BIOLOGY, 2007, Peer-reviewed

The AID Dilemma: Infection, or Cancer?
Tasuku Honjo; Maki Kobayashi; Nasim Begum; Ai Kotani; Somayeh Sabouri; Hitoshi Nagaoka
ADVANCES IN CANCER RESEARCH, VOL 113, 2012, Peer-reviewed

The AID dilemma: infection, or cancer?
HonjoTasuku; Kobayashi Maki; Begum Nasim; Kotani Ai; Sabouri Somayeh; Nagaoka Hitoshi
Advances in cancer research, 2012, Peer-reviewed

Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition.
Nasim A Begum; Farazul Haque; Andre Stanlie; Afzal Husain; Samiran Mondal; Mikiyo Nakata; Takako Taniguchi; Hisaaki Taniguchi; Tasuku Honjo
The EMBO journal, 15 Jun. 2021

SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination
Afzal Husain; Jianliang Xu; Hodaka Fujii; Mikiyo Nakata; Maki Kobayashi; Ji-Yang Wang; Jan Rehwinkel; Tasuku Honjo; Nasim A Begum
The EMBO Journal, 03 Aug. 2020

RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase
Ziwei Yin; Maki Kobayashi; Wenjun Hu; Koichi Higashi; Nasim A. Begum; Ken Kurokawa; Tasuku Honjo
Proceedings of the National Academy of Sciences, 26 May 2020

Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells
Afzal Husain; Nasim Begum; Maki Kobayashi; Tasuku Honjo
BIO-PROTOCOL, 2020

Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination
Azza Al Ismail; Afzal Husain; Maki Kobayashi; Tasuku Honjo; Nasim A Begum
International Immunology, 30 Dec. 2017

Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
Samiran Mondal; Nasim A. Begum; Wenjun Hu; Tasuku Honjo
Proceedings of the National Academy of Sciences, 15 Mar. 2016

Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
Afzal Husain; Nasim A. Begum; Takako Taniguchi; Hisaaki Taniguchi; Maki Kobayashi; Tasuku Honjo
Nature Communications, 04 Feb. 2016
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Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
Wenjun Hu; Nasim A. Begum; Samiran Mondal; Andre Stanlie; Tasuku Honjo
Proceedings of the National Academy of Sciences, Apr. 2015

Molecular Mechanisms of AID Function
Nasim A. Begum; Hitoshi Nagaoka; Maki Kobayashi; Tasuku Honjo
Molecular Biology of B Cells, 2015

Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination
A. S. Yousif; A. Stanlie; N. A. Begum; T. Honjo
International Immunology, 03 Jul. 2014

Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
Andre Stanlie; Ashraf S. Yousif; Hideo Akiyama; Tasuku Honjo; Nasim A. Begum
Molecular Cell, Jul. 2014

Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
A. S. Yousif; A. Stanlie; S. Mondal; T. Honjo; N. A. Begum
Proceedings of the National Academy of Sciences, 03 Mar. 2014

C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
Somayeh Sabouri; Maki Kobayashi; Nasim A. Begum; Jianliang Xu; Kouji Hirota; Tasuku Honjo
Proceedings of the National Academy of Sciences, 11 Feb. 2014
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Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
M. Aida; N. Hamad; A. Stanlie; N. A. Begum; T. Honjo
Proceedings of the National Academy of Sciences, Apr. 2013

The Non-Canonical function of UNG in AID induced Antibody Gene Diversification
Yousif Ashraf; Begum Nasim; Honjo Tasuku
Frontiers in Immunology, 2013

The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation
Nasim A. Begum; Andre Stanlie; Mikiyo Nakata; Hideo Akiyama; Tasuku Honjo
Journal of Biological Chemistry, Jul. 2012

Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
Nasim A. Begum; Tasuku Honjo
Biochemistry, Jun. 2012

An Evolutionary View of the Mechanism for Immune and Genome Diversity
Lucia Kato; Andre Stanlie; Nasim A. Begum; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo
The Journal of Immunology, 04 Apr. 2012

The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination
Andre Stanlie; Nasim A. Begum; Hideo Akiyama; Tasuku Honjo; Dale A. Ramsden
PLoS Genetics, Apr. 2012

Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes
L. Kato; N. A. Begum; A. M. Burroughs; T. Doi; J. Kawai; C. O. Daub; T. Kawaguchi; F. Matsuda; Y. Hayashizaki; T. Honjo
Proceedings of the National Academy of Sciences, 14 Feb. 2012
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X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells
Kate L. Jones; Michael Roche; Michael P. Gantier; Nasim A. Begum; Tasuku Honjo; Salvatore Caradonna; Bryan R. G. Williams; Johnson Mak
Journal of Biological Chemistry, 11 Jun. 2010

Author's reply: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
Z. Sabouri; I.-m. Okazaki; R. Shinkura; N. Begum; H. Nagaoka; T. Honjo
International Immunology, Feb. 2010

Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination
A. Stanlie; M. Aida; M. Muramatsu; T. Honjo; N. A. Begum
Proceedings of the National Academy of Sciences, 2010
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AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
Maki Kobayashi; Masatoshi Aida; Hitoshi Nagaoka; Nasim A. Begum; Yoko Kitawaki; Mikiyo Nakata; Andre Stanlie; Tomomitsu Doi; Lucia Kato; Il-mi Okazaki; Reiko Shinkura; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo
Proceedings of the National Academy of Sciences, 29 Dec. 2009
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Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
Z. Sabouri; I.-m. Okazaki; R. Shinkura; N. Begum; H. Nagaoka; D. Tsuchimoto; Y. Nakabeppu; T. Honjo
International Immunology, Jun. 2009

Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
Nasim A. Begum; Andre Stanlie; Tomomitsu Doi; Yoko Sasaki; Hai Wei Jin; Yong Sung Kim; Hitoshi Nagaoka; Tasuku Honjo
Proceedings of the National Academy of Sciences, 06 Feb. 2009

B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
Thinh Huy Tran; Mikiyo Nakata; Keiichiro Suzuki; Nasim A Begum; Reiko Shinkura; Sidonia Fagarasan; Tasuku Honjo; Hitoshi Nagaoka
Nature Immunology, 2009
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Molecular mechanism for generation of antibody memory
Velizar Shivarov; Reiko Shinkura; Tomomitsu Doi; Nasim A Begum; Hitoshi Nagaoka; Il-Mi Okazaki; Satomi Ito; Taichiro Nonaka; Kazuo Kinoshita; Tasuku Honjo
Philosophical Transactions of the Royal Society B: Biological Sciences, Nov. 2008

Differential Type I IFN-Inducing Abilities of Wild-Type versus Vaccine Strains of Measles Virus
Masashi Shingai; Takashi Ebihara; Nasim A. Begum; Atsushi Kato; Toshiki Honma; Kenji Matsumoto; Hirohisa Saito; Hisashi Ogura; Misako Matsumoto; Tsukasa Seya
The Journal of Immunology, Oct. 2007

Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model
Ikuo Shiratori; Yasuhiko Suzuki; Hiroyuki Oshiumi; Nasim A. Begum; Takashi Ebihara; Misako Matsumoto; Kaoru Hazeki; Ken Kodama; Yasuo Kashiwazaki; Tsukasa Seya
Cancer Science, 2007

Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
Nasim A. Begum; Nakako Izumi; Momoko Nishikori; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo
Journal of Biological Chemistry, 06 Nov. 2006

A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
A. Kotani; I.-m. Okazaki; M. Muramatsu; K. Kinoshita; N. A. Begum; T. Nakajima; H. Saito; T. Honjo
Proceedings of the National Academy of Sciences, 22 Mar. 2005

Uracil DNA Glycosylase Activity Is Dispensable for Immunoglobulin Class Switch
N. A. Begum
Science, 20 Aug. 2004

De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
N. A. Begum; K. Kinoshita; M. Muramatsu; H. Nagaoka; R. Shinkura; T. Honjo
Proceedings of the National Academy of Sciences, Aug. 2004

Separate domains of AID are required for somatic hypermutation and class-switch recombination
Reiko Shinkura; Satomi Ito; Nasim A Begum; Hitoshi Nagaoka; Masamichi Muramatsu; Kazuo Kinoshita; Yoshimasa Sakakibara; Hiroko Hijikata; Tasuku Honjo
Nature Immunology, Jun. 2004

Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
Satomi Ito; Hitoshi Nagaoka; Reiko Shinkura; Nasim Begum; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo
Proceedings of the National Academy of Sciences, 09 Feb. 2004

Mycobacterium bovis BCG Cell Wall-Specific Differentially Expressed Genes Identified by Differential Display and cDNA Subtraction in Human Macrophages
Nasim A. Begum; Kazuo Ishii; Mitsue Kurita-Taniguchi; Masako Tanabe; Mika Kobayashi; Yasuhiro Moriwaki; Misako Matsumoto; Yasuo Fukumori; Ichiro Azuma; Kumao Toyoshima; Tsukasa Seya
Infection and Immunity, Feb. 2004

Structural–functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag
Tsukasa Seya; Misako Matsumoto; Shoutaro Tsuji; Nasim A Begum; Ichiro Azuma; Kumao Toyoshima
Microbes and Infection, Jul. 2002

Mycobacterium bovis BCG Cell Wall and Lipopolysaccharide Induce a Novel Gene, BIGM103, Encoding a 7-TM Protein: Identification of a New Protein Family Having Zn-Transporter and Zn-Metalloprotease Signatures
Nasim A. Begum; Mika Kobayashi; Yasuhiro Moriwaki; Misako Matsumoto; Kumao Toyoshima; Tsukasa Seya
Genomics, 2002

RNA interference for mammalian cells.
Hiroyuki OSHIUMI; Nasim A. Begum; Misako MATSUMOTO; Tsukasa SEYA
Folia Pharmacologica Japonica, 2002

Mycoplasma fermentansLipoprotein M161Ag-Induced Cell Activation Is Mediated by Toll-Like Receptor 2: Role of N-Terminal Hydrophobic Portion in its Multiple Functions
Miyuki Nishiguchi; Misako Matsumoto; Toshifumi Takao; Masaru Hoshino; Yasutsugu Shimonishi; Shoutaro Tsuji; Nasim A. Begum; Osamu Takeuchi; Shizuo Akira; Kumao Toyoshima; Tsukasa Seya
The Journal of Immunology, Feb. 2001

Identification and characterization of a silencer regulatory element in the 3′-flanking region of the murine CD46 gene
Midori NOMURA; Akira TSUJIMURA; Nasim A. BEGUM; Misako MATSUMOTO; Hiroetsu WABIKO; Kumao TOYOSHIMA; Tsukasa SEYA
Biochemical Journal, 10 Oct. 2000

External funds: Kakenhi

ole of R-loop in antibody class switching and B cell lymphomagenesis
Grant-in-Aid for Scientific Research (C)
Basic Section 43010:Molecular biology-related
Kyoto University
Nasim Begum
From 01 Apr. 2021, To 31 Mar. 2024, Project Closed
CSR;AID;HNRNPU;DNA Repair;NHEJ;MED12;R-loop;B Cells;Genomic Instability;B cell
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06015/

Analysis of the molecular mechanism of IgH gene diversification depending on RNA-editing by AID
Grant-in-Aid for Scientific Research (A)
Medium-sized Section 49:Pathology, infection/immunology, and related fields
Kyoto University
TASUKU HONJO
From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
AID;RNA編集;免疫グロブリン遺伝子;トポイソメラーゼ 1;トポイソメラーゼ１;トポイソメラーゼ　１
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H01027/

Mechanism of targeted DNA cleavage and recombination by AID
Grant-in-Aid for Scientific Research (C)
Kyoto University
Nasim Begum
From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
AID;CSR;Recombination;hnRNPK;hnRNPL;Phf5a;Samhd1;Brd2;BiFC;hnRNP;Serbp1;SHM;Translocation;Chromatin regulator
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07214/

Transcription coupled chromatin regulation in AID induced genome rearrangement
Grant-in-Aid for Scientific Research (C)
Kyoto University
NasimAra BEGUM
From 01 Apr. 2012, To 31 Mar. 2015, Project Closed
AID;SHM;CSR;H3K4me3;FACT;SPT6;BRD4;UNG;TOP1;Genomic instability
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590352/

Mechanism for genome instability by activation induced cytidine deaminase induced-reduction of topoisomerase1
Grant-in-Aid for Specially Promoted Research
Biological Sciences
Kyoto University
Tasuku HONJO
From 01 Apr. 2010, To 31 Mar. 2016, Project Closed
体細胞突然変異;クラススイッチ組換え;RNA編集;DNA修復;DNA切断;組換え;獲得免疫;免疫帰国;大規模シークエンス;FACT複合体
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22000015/

AID-dependent genetic alteration mechanism to generate antigen-specific antibodies
Grant-in-Aid for Specially Promoted Research
Biological Sciences
Kyoto University
Tasuku HONJO
From 01 Apr. 2005, To 31 Mar. 2010, Project Closed
クラススイッチ;体細胞突然変異;RNA編集;ウラシルDNAグリコシラーゼ;免疫沈降法;マイクロアレイ法;免役学;抗体;ゲノム;癌
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17002015/

Molecular mechanism of the AID-recombinosome formation which is essential for vaccine-induced antibody gene diversification
Grant-in-Aid for Scientific Research (A)
Medium-sized Section 49:Pathology, infection/immunology, and related fields
Kyoto University
本庶佑
From 01 Apr. 2022, To 31 Mar. 2025, Granted
遺伝子組換え;抗体遺伝子組換え;エンハンサー由来RNA;液ー液相分離;液一液相分離;hnRNP K;hnRNP U;R-ループ
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00449/

Role of Enhancer RNA in Switch, Suicide, and Oncogenic Recombination in B cells
Grant-in-Aid for Scientific Research (C)
Basic Section 43010:Molecular biology-related
Kyoto University
Begum NasimAra
From 01 Apr. 2024, To 31 Mar. 2027, Granted
AID;CSR;Ig;LSR;Genomic Instability
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09325/

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