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BEGUM NasimAra

ベーガム ナシムアラ

医学研究科 附属がん免疫総合研究センター 免疫ゲノム医学講座（産学共同） 特定准教授

BEGUM NasimAra
list
    Last Updated :2025/04/23

    基本情報

    学位

    • Ｍ．Ｓ．(ビスババラチ大学)
    • Ｐｈ．Ｄ．(ジャダプール大学)

    経歴

    • 京都大学, Department of Immunology and Genomic Medicine, Associate Professor
    • 京都大学, Department of Immunology and Genomic Medicine, Assistant Professor
    • Indian Institute of Chemical Biology, Calcutta, India, Department of Biophysics, Scientist

    ID,URL

    researchmap URL

    list
      Last Updated :2025/04/23

      研究

      研究キーワード

      • Antibody Class Switch Recombination
      • Epigenomic Regulation
      • Genomic Instability

      研究分野

      • ライフサイエンス, 免疫学
      • ライフサイエンス, 分子生物学

      論文

      • Mycobacterium bovis Bacillus Calmette-Guerin and Its Cell Wall Complex Induce a Novel Lysosomal Membrane Protein, SIMPLE, that Bridges the Missing Link between Lipopolysaccharide and p53-inducible Gene, LITAF(PIG7), and Estrogen-inducible Gene, EET-1
        Yasuhiro Moriwaki; Nasim A. Begum; Mika Kobayashi; Misako Matsumoto; Kumao Toyoshima; Tsukasa Seya
        Journal of Biological Chemistry, 2001年06月22日
      • High serum levels of additional IL-18 forms may be reciprocally correlated with IgE levels in patients with atopic dermatitis
        Kyoko Shida; Hiroko Koizumi; Ikuo Shiratori; Misako Matsumoto; Satomi Kikkawa; Shoutaro Tsuji; Nasim A. Begum; Yasuo Fukumori; Kumao Toyoshima; Tsukasa Seya
        Immunology Letters, 2001年12月03日
      • A comparative analysis of the antigenic, structural, and functional properties of three different preparations of recombinant human interleukin- 18
        Satomi Kikkawa; Kyoko Shida; Haruki Okamura; Nasim A. Begum; Misako Matsumoto; Shoutaro Tsuji; Midori Nomura; Yasuhiko Suzuki; Kumao Toyoshima; Tsukasa Seya
        Journal of Interferon and Cytokine Research, 2000年
      • Human MD-1 homologue is a BCG-regulated gene product in monocytes: Its identification by differential display
        Nasim A. Begum; Shoutaro Tsuji; Midori Nomura; Kyoko Shida; Ichiro Azuma; Akira Hayashi; Misako Matsumoto; Tsukasa Seya; Kumao Toyoshima
        Biochemical and Biophysical Research Communications, 1999年03月16日
      • Two receptor theory in innate immune activation: Studies on the receptors for bacillus culmet guillen-cell wall skeleton
        Tsukasa Seya; Misako Matsumoto; Shoutaro Tsuji; Nasim A. Begum; Midori Nomura; Ichiro Azuma; Akira Hayashi; Kumao Toyoshima
        Archivum Immunologiae et Therapiae Experimentalis, 2001年
      • BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL
        Santosh K Gothwal; Ahmed M Refaat; Mikiyo Nakata; Andre Stanlie; Tasuku Honjo; Nasim A Begum
        Nucleic Acids Research, 2024年04月03日
      • HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression
        Ahmed M. Refaat; Mikiyo Nakata; Afzal Husain; Hidetaka Kosako; Tasuku Honjo; Nasim A. Begum
        Cell Reports, 2023年03月
        この論文にアクセスする：
      • Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory
        Masamichi Muramatsu; Hitoshi Nagaoka; Reiko Shinkura; Nasim A. Begum; Tasuku Honjo
        Advances in Immunology, 2007年, 査読有り
      • Regulation of AID Function In Vivo
        Reiko Shinkura; Il-mi Okazaki; Taro Muto; Nasim A. Begum; Tasuku Honjo
        MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION XI: B CELL BIOLOGY, 2007年, 査読有り
      • The AID Dilemma: Infection, or Cancer?
        Tasuku Honjo; Maki Kobayashi; Nasim Begum; Ai Kotani; Somayeh Sabouri; Hitoshi Nagaoka
        ADVANCES IN CANCER RESEARCH, VOL 113, 2012年, 査読有り
      • The AID dilemma: infection, or cancer?
        Honjo Tasuku; Kobayashi Maki; Begum Nasim; Kotani Ai; Sabouri Somayeh; Nagaoka Hitoshi
        Advances in cancer research, 2012年, 査読有り
      • Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition.
        Nasim A Begum; Farazul Haque; Andre Stanlie; Afzal Husain; Samiran Mondal; Mikiyo Nakata; Takako Taniguchi; Hisaaki Taniguchi; Tasuku Honjo
        The EMBO journal, 2021年06月15日
      • SAMHD 1‐mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination
        Afzal Husain; Jianliang Xu; Hodaka Fujii; Mikiyo Nakata; Maki Kobayashi; Ji-Yang Wang; Jan Rehwinkel; Tasuku Honjo; Nasim A Begum
        The EMBO Journal, 2020年08月03日
      • RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase
        Ziwei Yin; Maki Kobayashi; Wenjun Hu; Koichi Higashi; Nasim A. Begum; Ken Kurokawa; Tasuku Honjo
        Proceedings of the National Academy of Sciences, 2020年05月26日
      • Native Co-immunoprecipitation Assay to Identify Interacting Partners of Chromatin-associated Proteins in Mammalian Cells
        Afzal Husain; Nasim Begum; Maki Kobayashi; Tasuku Honjo
        BIO-PROTOCOL, 2020年
      • Depletion of recombination-specific cofactors by the C-terminal mutant of the activation-induced cytidine deaminase causes the dominant negative effect on class switch recombination
        Azza Al Ismail; Afzal Husain; Maki Kobayashi; Tasuku Honjo; Nasim A Begum
        International Immunology, 2017年12月30日
      • Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
        Samiran Mondal; Nasim A. Begum; Wenjun Hu; Tasuku Honjo
        Proceedings of the National Academy of Sciences, 2016年03月15日
      • Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
        Afzal Husain; Nasim A. Begum; Takako Taniguchi; Hisaaki Taniguchi; Maki Kobayashi; Tasuku Honjo
        Nature Communications, 2016年02月04日
        この論文にアクセスする：
      • Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
        Wenjun Hu; Nasim A. Begum; Samiran Mondal; Andre Stanlie; Tasuku Honjo
        Proceedings of the National Academy of Sciences, 2015年04月
      • Molecular Mechanisms of AID Function
        Nasim A. Begum; Hitoshi Nagaoka; Maki Kobayashi; Tasuku Honjo
        Molecular Biology of B Cells, 2015年
      • Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination
        A. S. Yousif; A. Stanlie; N. A. Begum; T. Honjo
        International Immunology, 2014年07月03日
      • Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
        Andre Stanlie; Ashraf S. Yousif; Hideo Akiyama; Tasuku Honjo; Nasim A. Begum
        Molecular Cell, 2014年07月
      • Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
        A. S. Yousif; A. Stanlie; S. Mondal; T. Honjo; N. A. Begum
        Proceedings of the National Academy of Sciences, 2014年03月03日
      • C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
        Somayeh Sabouri; Maki Kobayashi; Nasim A. Begum; Jianliang Xu; Kouji Hirota; Tasuku Honjo
        Proceedings of the National Academy of Sciences, 2014年02月11日
        この論文にアクセスする：
      • Accumulation of the FACT complex, as well as histone H3.3, serves as a target marker for somatic hypermutation
        M. Aida; N. Hamad; A. Stanlie; N. A. Begum; T. Honjo
        Proceedings of the National Academy of Sciences, 2013年04月
      • The Non-Canonical function of UNG in AID induced Antibody Gene Diversification
        Yousif Ashraf; Begum Nasim; Honjo Tasuku
        Frontiers in Immunology, 2013年
      • The Histone Chaperone Spt6 Is Required for Activation-induced Cytidine Deaminase Target Determination through H3K4me3 Regulation
        Nasim A. Begum; Andre Stanlie; Mikiyo Nakata; Hideo Akiyama; Tasuku Honjo
        Journal of Biological Chemistry, 2012年07月
      • Evolutionary Comparison of the Mechanism of DNA Cleavage with Respect to Immune Diversity and Genomic Instability
        Nasim A. Begum; Tasuku Honjo
        Biochemistry, 2012年06月
      • An Evolutionary View of the Mechanism for Immune and Genome Diversity
        Lucia Kato; Andre Stanlie; Nasim A. Begum; Maki Kobayashi; Masatoshi Aida; Tasuku Honjo
        The Journal of Immunology, 2012年04月04日
      • The DSIF Subunits Spt4 and Spt5 Have Distinct Roles at Various Phases of Immunoglobulin Class Switch Recombination
        Andre Stanlie; Nasim A. Begum; Hideo Akiyama; Tasuku Honjo; Dale A. Ramsden
        PLoS Genetics, 2012年04月
      • Nonimmunoglobulin target loci of activation-induced cytidine deaminase (AID) share unique features with immunoglobulin genes.
        Kato Lucia; Begum Nasim A; Burroughs A Maxwell; Doi Tomomitsu; Kawai Jun; Daub Carsten O; Kawaguchi Takahisa; Matsuda Fumihiko; Hayashizaki Yoshihide; Honjo Tasuku
        Proceedings of the National Academy of Sciences of the United States of America, 2012年02月14日
        この論文にアクセスする：
      • X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells
        Kate L. Jones; Michael Roche; Michael P. Gantier; Nasim A. Begum; Tasuku Honjo; Salvatore Caradonna; Bryan R. G. Williams; Johnson Mak
        Journal of Biological Chemistry, 2010年06月11日
      • Author's reply: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
        Z. Sabouri; I.-m. Okazaki; R. Shinkura; N. Begum; H. Nagaoka; T. Honjo
        International Immunology, 2010年02月
      • Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.
        Stanlie Andre; Aida Masatoshi; Muramatsu Masamichi; Honjo Tasuku; Begum Nasim A
        Proceedings of the National Academy of Sciences of the United States of America, 2010年
        この論文にアクセスする：
      • AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
        Maki Kobayashi; Masatoshi Aida; Hitoshi Nagaoka; Nasim A. Begum; Yoko Kitawaki; Mikiyo Nakata; Andre Stanlie; Tomomitsu Doi; Lucia Kato; Il-mi Okazaki; Reiko Shinkura; Masamichi Muramatsu; Kazuo Kinoshita; Tasuku Honjo
        Proceedings of the National Academy of Sciences, 2009年12月29日
        この論文にアクセスする：
      • Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes
        Z. Sabouri; I.-m. Okazaki; R. Shinkura; N. Begum; H. Nagaoka; D. Tsuchimoto; Y. Nakabeppu; T. Honjo
        International Immunology, 2009年06月
      • Further evidence for involvement of a noncanonical function of uracil DNA glycosylase in class switch recombination
        Nasim A. Begum; Andre Stanlie; Tomomitsu Doi; Yoko Sasaki; Hai Wei Jin; Yong Sung Kim; Hitoshi Nagaoka; Tasuku Honjo
        Proceedings of the National Academy of Sciences, 2009年02月06日
      • B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
        Thinh Huy Tran; Mikiyo Nakata; Keiichiro Suzuki; Nasim A Begum; Reiko Shinkura; Sidonia Fagarasan; Tasuku Honjo; Hitoshi Nagaoka
        Nature Immunology, 2009年
        この論文にアクセスする：
      • Molecular mechanism for generation of antibody memory
        Velizar Shivarov; Reiko Shinkura; Tomomitsu Doi; Nasim A Begum; Hitoshi Nagaoka; Il-Mi Okazaki; Satomi Ito; Taichiro Nonaka; Kazuo Kinoshita; Tasuku Honjo
        Philosophical Transactions of the Royal Society B: Biological Sciences, 2008年11月
      • Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus
        SHINGAI M
        J Immunol, 2007年10月
      • Recombinant interleukin-12 and interleukin-18 antitumor therapy in a guinea-pig hepatoma cell implant model
        Ikuo Shiratori; Yasuhiko Suzuki; Hiroyuki Oshiumi; Nasim A. Begum; Takashi Ebihara; Misako Matsumoto; Kaoru Hazeki; Ken Kodama; Yasuo Kashiwazaki; Tsukasa Seya
        Cancer Science, 2007年
      • Requirement of Non-canonical Activity of Uracil DNA Glycosylase for Class Switch Recombination
        Nasim A. Begum; Nakako Izumi; Momoko Nishikori; Hitoshi Nagaoka; Reiko Shinkura; Tasuku Honjo
        Journal of Biological Chemistry, 2006年11月06日
      • A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression
        A. Kotani; I.-m. Okazaki; M. Muramatsu; K. Kinoshita; N. A. Begum; T. Nakajima; H. Saito; T. Honjo
        Proceedings of the National Academy of Sciences, 2005年03月22日
      • Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch
        BEGUM N. A.
        Science, 2004年08月20日
      • De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
        N. A. Begum; K. Kinoshita; M. Muramatsu; H. Nagaoka; R. Shinkura; T. Honjo
        Proceedings of the National Academy of Sciences, 2004年08月
      • Separate domains of AID are required for somatic hypermutation and class-switch recombination
        Reiko Shinkura; Satomi Ito; Nasim A Begum; Hitoshi Nagaoka; Masamichi Muramatsu; Kazuo Kinoshita; Yoshimasa Sakakibara; Hiroko Hijikata; Tasuku Honjo
        Nature Immunology, 2004年06月
      • Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1
        Satomi Ito; Hitoshi Nagaoka; Reiko Shinkura; Nasim Begum; Masamichi Muramatsu; Mikiyo Nakata; Tasuku Honjo
        Proceedings of the National Academy of Sciences, 2004年02月09日
      • Mycobacterium bovis BCG Cell Wall-Specific Differentially Expressed Genes Identified by Differential Display and cDNA Subtraction in Human Macrophages
        Nasim A. Begum; Kazuo Ishii; Mitsue Kurita-Taniguchi; Masako Tanabe; Mika Kobayashi; Yasuhiro Moriwaki; Misako Matsumoto; Yasuo Fukumori; Ichiro Azuma; Kumao Toyoshima; Tsukasa Seya
        Infection and Immunity, 2004年02月
      • Structural–functional relationship of pathogen-associated molecular patterns: lessons from BCG cell wall skeleton and mycoplasma lipoprotein M161Ag
        Tsukasa Seya; Misako Matsumoto; Shoutaro Tsuji; Nasim A Begum; Ichiro Azuma; Kumao Toyoshima
        Microbes and Infection, 2002年07月
      • Mycobacterium bovis BCG Cell Wall and Lipopolysaccharide Induce a Novel Gene, BIGM103, Encoding a 7-TM Protein: Identification of a New Protein Family Having Zn-Transporter and Zn-Metalloprotease Signatures
        Nasim A. Begum; Mika Kobayashi; Yasuhiro Moriwaki; Misako Matsumoto; Kumao Toyoshima; Tsukasa Seya
        Genomics, 2002年
      • RNA interference (RNAi)を用いた哺乳類細胞での遺伝子ノックアウト
        押海 裕之; Begum Nasim A.; 松本 美佐子; 瀬谷 司
        日本薬理学雑誌, 2002年
      • Mycoplasma fermentansLipoprotein M161Ag-Induced Cell Activation Is Mediated by Toll-Like Receptor 2: Role of N-Terminal Hydrophobic Portion in its Multiple Functions
        Miyuki Nishiguchi; Misako Matsumoto; Toshifumi Takao; Masaru Hoshino; Yasutsugu Shimonishi; Shoutaro Tsuji; Nasim A. Begum; Osamu Takeuchi; Shizuo Akira; Kumao Toyoshima; Tsukasa Seya
        The Journal of Immunology, 2001年02月
      • Identification and characterization of a silencer regulatory element in the 3′-flanking region of the murine CD46 gene
        Midori NOMURA; Akira TSUJIMURA; Nasim A. BEGUM; Misako MATSUMOTO; Hiroetsu WABIKO; Kumao TOYOSHIMA; Tsukasa SEYA
        Biochemical Journal, 2000年10月10日

      外部資金：科学研究費補助金

      • Role of R-loop in antibody class switching and B cell lymphomagenesis
        基盤研究(C)
        小区分43010:分子生物学関連
        京都大学
        Begum NasimAra
        自 2021年04月01日, 至 2024年03月31日, 交付
        CSR;R-loop;AID;HNRNPU;DNA Repair;NHEJ;B Cells;Genomic Instability;B cell
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06015/
      • AIDのRNA編集による抗体遺伝子多様化機構の解明
        基盤研究(A)
        中区分49:病理病態学、感染・免疫学およびその関連分野
        京都大学
        本庶 佑
        自 2019年04月01日, 至 2022年03月31日, 完了
        AID;RNA編集;免疫グロブリン遺伝子;トポイソメラーゼ 1;トポイソメラーゼ１;トポイソメラーゼ　１
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H01027/
      • Mechanism of targeted DNA cleavage and recombination by AID
        基盤研究(C)
        京都大学
        Begum NasimAra
        自 2016年04月01日, 至 2019年03月31日, 完了
        AID;CSR;Recombination;hnRNPK;hnRNPL;Phf5a;Samhd1;Brd2;BiFC;hnRNP;Serbp1;SHM;Translocation;Chromatin regulator
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07214/
      • ＡＩＤによるゲノム再構成に伴うクロマチン制御
        基盤研究(C)
        京都大学
        BEGUM NasimAra
        自 2012年04月01日, 至 2015年03月31日, 完了
        AID;SHM;CSR;H3K4me3;FACT;SPT6;BRD4;UNG;TOP1;Genomic instability
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24590352/
      • ＡＩＤによるｔｏｐｏｉｓｏｍｅｒａｓｅ１を介したゲノム不安定性誘導のメカニズム
        特別推進研究
        生物系
        京都大学
        本庶 佑
        自 2010年04月01日, 至 2016年03月31日, 完了
        体細胞突然変異;クラススイッチ組換え;RNA編集;DNA修復;DNA切断;組換え;獲得免疫;免疫帰国;大規模シークエンス;FACT複合体
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22000015/
      • ΑΙＤによる抗原刺激依存性抗体遺伝子改編機構の研究
        特別推進研究
        生物系
        京都大学
        本庶 佑
        自 2005年04月01日, 至 2010年03月31日, 完了
        クラススイッチ;体細胞突然変異;RNA編集;ウラシルDNAグリコシラーゼ;免疫沈降法;マイクロアレイ法;免役学;抗体;ゲノム;癌
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17002015/
      • ワクチン接種による抗体産生に必須なAID-recombinosome形成機構解明
        基盤研究(A)
        中区分49:病理病態学、感染・免疫学およびその関連分野
        京都大学
        本庶 佑
        自 2022年04月01日, 至 2025年03月31日, 交付
        遺伝子組換え;抗体遺伝子組換え;エンハンサー由来RNA;液ー液相分離;hnRNP K;hnRNP U;R-ループ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00449/
      • Role of Enhancer RNA in Switch, Suicide, and Oncogenic Recombination in B cells
        基盤研究(C)
        小区分43010:分子生物学関連
        京都大学
        Begum NasimAra
        自 2024年04月01日, 至 2027年03月31日, 交付
        AID;CSR;Ig;LSR;Genomic Instability
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09325/

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