Basic Information

Faculty

• 医学部

Professional Memberships

• From 2009, To Present

  THE JAPAN NEUROSCIENCE SOCIETY
• From 2009, To 2012

  Society for neuroscience

Academic Degree

• 修士（生命科学）(京都大学)
• 博士（生命科学）(京都大学)

Research History

• From Oct. 2022, To Present

  PRESTO researcher
• From Aug. 2021, To Present

  Kyoto University Graduate School of Medicine, Department of Pharmacology, Assistant professor
• From 2016, To Jul. 2021

  Kyoto University Graduate School of Medicine, Department of Pharmacology, Assistant professor
• From 2016, To 2016

  RIKEN, Special Postdoctoral Researcher
• From 2013, To 2016

  Research Fellowships for Young Scientists (PD), Japan Society for the Promotion of Science
• From 2013, To 2015

  Osaka Bioscience Institute (OBI)
• From 2010, To 2013

  Research Fellowships for Young Scientists (DC1), Japan Society for the Promotion of Science

ID,URL

• ORCID ID

  0000-0002-1753-2893

• J-Global ID

  201601008663412986

• External link

  https://twitter.com/agoto_neurosci

researchmap URL

• https://researchmap.jp/7000017647

Research

Research Topics, Overview of the research

• Research Topics

  A role of structural plasticity in hippocampal memory.

• Overview of the research

  New memory is formed after neuron establishes the new synapse or strengthens the synapse. Long-term potentiation(LTP) is a persistent increase in synaptic strength following high-frequency stimulation and it is widely considered as one major cellular mechanisms that underlies learning and memory. After LTP induction,the post synaptic spine also becomes larger. this is called structural LTP or sLTP. My research is to study a function of sLTP during memory formation in hippocampus.

Research Interests

• Imaging
• Memory
• Molecualr biology
• Neuroscience

Research Areas

• Life sciences, Neuroscience - general, Synaptic plasticity
• Life sciences, Neuroscience - general, Synaptic plasticity

Papers

• 

  Offline neuronal activity and synaptic plasticity during sleep and memory consolidation

  Akihiro Goto; Yasunori Hayashi

  Neuroscience Research, Dec. 2022, Peer-reviewed, Lead author, Corresponding author

  
• 

  Synaptic plasticity during systems memory consolidation

  Akihiro Goto

  Neuroscience Research, Jun. 2022, Peer-reviewed, Lead author, Corresponding author

  
• 

  Shared and unique properties of place cells in anterior cingulate cortex and hippocampus

  Ayaka Bota; Akihiro Goto; Suzune Tsukamoto; Alexander Schmidt; Fred Wolf; Alessandro Luchetti; Junichi Nakai; Hajime Hirase; Yasunori Hayashi

  30 Mar. 2021

  
• Stepwise synaptic plasticity events drive the early phase of memory consolidation

  Akihiro Goto; Ayaka Bota; Ken Miya; Jingbo Wang; Suzune Tsukamoto; Xinzhi Jiang; Daichi Hirai; Masanori Murayama; Tomoki Matsuda; Thomas J. McHugh; Takeharu Nagai; Yasunori Hayashi

  Science, 12 Nov. 2021, Peer-reviewed, Lead author

  
• Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning

  Takashi Yamaguchi; Akihiro Goto; Ichiro Nakahara; Satoshi Yawata; Takatoshi Hikida; Michiyuki Matsuda; Kazuo Funabiki; Shigetada Nakanishi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2015, Peer-reviewed

  
• 

  Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice

  Akihiro Goto; Ichiro Nakahara; Takashi Yamaguchi; Yuji Kamioka; Kenta Sumiyama; Michiyuki Matsuda; Shigetada Nakanishi; Kazuo Funabiki

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2015, Peer-reviewed, Lead author

  
• 

  PKA modulation of Rac in neuronal cells

  Akihiro Goto; Yuji Kamioka; Michiyuki Matsuda

  FRONTIERS IN CELLULAR NEUROSCIENCE, Oct. 2014, Peer-reviewed, Lead author

  
• Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells

  Takehiko Ueyama; Hirofumi Sakaguchi; Takashi Nakamura; Akihiro Goto; Shigefumi Morioka; Aya Shimizu; Kazuki Nakao; Yoshitaka Hishikawa; Yuzuru Ninoyu; Hidetoshi Kassai; Shiro Suetsugu; Takehiko Koji; Bernd Fritzsch; Shigenobu Yonemura; Yasuo Hisa; Michiyuki Matsuda; Atsu Aiba; Naoaki Saito

  JOURNAL OF CELL SCIENCE, May 2014, Peer-reviewed

  
• Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase

  Takeshi Nakamura; Sayaka Yasuda; Hiroyuki Nagai; Shingo Koinuma; So Morishita; Akihiro Goto; Tatsuo Kinashi; Naoyuki Wada

  Genes to Cells, Nov. 2013, Peer-reviewed

  
• 

  GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1

  Akihiro Goto; Kenta Sumiyama; Yuji Kamioka; Eiji Nakasyo; Keisuke Ito; Mitsuhiro Iwasaki; Hideki Enomoto; Michiyuki Matsuda

  Journal of Neuroscience, 13 Mar. 2013, Peer-reviewed, Lead author

  
• 

  Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells

  Akihiro Goto; Mikio Hoshino; Michiyuki Matsuda; Takeshi Nakamura

  MOLECULAR BIOLOGY OF THE CELL, May 2011, Peer-reviewed, Lead author

  

Misc.

• p53によるATMのフィードバック制御:FRETバイオセンサーを用いた解析

  林亜里香; 後藤明弘; 隅山健太; 松田道行; 松田道行; CANDEIAS Marco

  日本分子生物学会年会プログラム・要旨集(Web), 2012

  
• Identifying the time and place where memories are consolidated

  後藤明弘

  Clinical Neuroscience, 01 Dec. 2022

  
• 光によるシナプス可塑性制御で明らかになった記憶固定化機構

  後藤明弘; 林康紀

  生物物理 (日本生物物理学会), 25 Jul. 2022, Peer-reviewed

  
• 

  光で記憶を消去する―記憶に睡眠が必要な理由を解明―

  後藤明弘

  神経科学ニュース （日本神経科学学会）, Feb. 2022, Peer-reviewed

  
• 

  New optogenetic tool to erase specific memory

  Akihiro Goto

  Photonics NEWS (Photonics Division), 10 May 2022, Peer-reviewed

  
• Inner ear hair cell-specific Cdc42-KO mice demonstrate progressive hearing loss by impaired actin turnover in stereocilia and apical junctions

  Takashi Nakamura; Takehiko Ueyama; Hirofumi Sakaguchi; Akihiro Goto; Shigefumi Morioka; Shigenobu Yonemura; Yasuo Hisa; Michiyuki Matsuda; Atsu Aiba; Naoaki Satio

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• Rap1B plays an instructive role in neuronal polarization through RalA and Nore1A in addition to PI3-kinase

  Takeshi Nakamura; Akihiro Goto; Michiyuki Matsuda; Tatsuo Kinashi

  NEUROSCIENCE RESEARCH, 2010

  
• FRET analysis of differences in signaling mechanism between dbcAMP- and NGF-induced neuritogenesis in PC12D cells

  Akihiro Goto; Takeshi Nakamura; Mikio Hoshino; Michiyuki Matsuda

  NEUROSCIENCE RESEARCH, 2010

  
• Differences in signaling mechanism and morphological change between dbcAMP- and NGF-induced neuritogenesis in PC12D cells

  Akihiro Goto; Takeshi Nakamura; Michiyuki Matsuda

  NEUROSCIENCE RESEARCH, 2009

  

Presentations

• Stepwise synaptic plasticity events drive memory consolidation

  Akihiro Goto

  The 53rd Frontier Brain Science Seminar Sponsored by Research Center for Idling Brain Science (RCIBS), 14 Oct. 2021, Invited

  
• A new optical method for identifying a time window of synaptic plasticity in hippocampus.

  Akihiro Goto

  14th BIRD Neuroscience seminar Tokyo University of Science, 02 Aug. 2018, Invited

  
• A new optical method for erasing hippocampal LTP and memory.

  Akihiro Goto

  Niigata University, 15 Mar. 2019, Invited

  

Media Coverage

• つらい記憶光で消去？PTSD、認知症治療に期待

  神戸新聞, 13面, 09 Jun. 2022, Paper

  
• Step by step consolidation

  Nature Reviews Neuroscience, (Research Highlights), 23, pages68–69, Dec. 2021

  
• 光で記憶を消去する―記憶に睡眠が必要な理由を解明―

  日本神経科学学会, 神経科学トピックス, Dec. 2021, Pr

  
• Using optogenetics, scientists pinpoint the location and timing of memory formation in mice

  STAT, STAT, Nov. 2021, Paper

  
• News and Topics

  National Museum of Nature and Science, milsil, ページ33 (論文紹介）, Jan. 2022, Paper

  
• News Pickup

  NHK radio, Nらじ, ニュースピックアップに出演, 15 Dec. 2021, Media report

  
• Erase aversive memory with light

  Yomiuri, Yomiuri (an evening newspaper), 8面に論文紹介とコメント掲載, 22 Nov. 2021, Paper

  
• Pickup news

  テレビ朝日, Japanese TV program, performed by zoom, 19 Nov. 2021, Media report

  

External funds: Kakenhi

• マカク属サルfMRIによる高次脳機能制御の全脳マッピングと神経回路の因果的証明

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 51:Brain sciences and related fields

  Kyoto University

  肥後 剛康

  From 27 Oct. 2020, To 31 Mar. 2025, Granted

  fMRI;霊長類;神経回路操作;サルfMRI;前頭前野;高次脳機能

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20KK0189/
• Revealing the function of offline LTP in memory consolidation

  Grant-in-Aid for Early-Career Scientists

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  Akihiro Goto

  From 01 Apr. 2020, To 31 Mar. 2022, Project Closed

  記憶;LTP;固定化;記憶が固定化;CALI;シナプス可塑性;学習;海馬;Cofilin;offline-LTP;cofilin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K15901/
• Time window of NMDA receptor-dependent LTP in memory formation and consolidation

  Grant-in-Aid for Early-Career Scientists

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  Akihiro Goto

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  LTP;CALI;記憶の形成;cofilin;Cofilin;sLTP;SuperNova

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14818/
• A new optical mothod for defining an individuality of memory

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  後藤 明弘

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  in vivo カルシウムイメージング;cofilin;SuperNova;記憶;LTP;アセンブリ;コフィリン;Cofilin;内視顕微鏡;Supernova

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H05949/
• Erasure of LTP and memory by light

  Grant-in-Aid for Scientific Research (C)

  Kyoto University;Institute of Physical and Chemical Research

  Akihiro Goto

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  cofilin;LTP;SuperNova;CALI;Cofilin;光操作;記憶の消去

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06728/
• Spatiotemporal analysis of synaptic plasticity in memory consolidation

  Grant-in-Aid for Scientific Research (B)

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  後藤 明弘

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  記憶固定化;LTP;CALI

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02720/
• Dynamics of memory circuits by synaptic plasticity

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  後藤 明弘

  From 16 Jun. 2022, To 31 Mar. 2024, Granted

  LTP;シナプス可塑性;学習;海馬;CALI

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H05496/

Education

Teaching subject(s)

• From Oct. 2017, To Mar. 2018

  薬理学

  Fall, 医学部
• From Oct. 2017, To Mar. 2018

  薬理学演習

  Fall, 医学部
• From Oct. 2017, To Mar. 2018

  薬理学実習

  Fall, 医学部
• From Apr. 2018, To Sep. 2018

  薬理学

  Spring, 医学部
• From Apr. 2018, To Sep. 2018

  薬理学演習

  Spring, 医学部
• From Apr. 2018, To Sep. 2018

  薬理学実習

  Spring, 医学部
• From Apr. 2019, To Sep. 2019

  薬理学

  Spring, 医学部
• From Apr. 2019, To Sep. 2019

  薬理学演習

  Spring, 医学部
• From Apr. 2019, To Sep. 2019

  薬理学実習

  Spring, 医学部

Administration

Faculty management (title, position)

• From 01 Apr. 2017, To 31 Mar. 2019

  医学図書館図書連絡委員

Academic, Social Contribution

Academic Contribution

• Optical approaches to temporal transformations of brain information representations: from behavior to synapses

  Planning, management, etc., Panel moderator

  From 01 Jul. 2022, To 01 Jul. 2022