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Goto, Akihiro

Graduate School of Medicine, Medicine Assistant Professor

Goto, Akihiro
list
    Last Updated :2022/06/28

    Basic Information

    Faculty

    • 医学部

    Professional Memberships

    • From 2009, To Present
      THE JAPAN NEUROSCIENCE SOCIETY
    • From 2009, To 2012
      Society for neuroscience

    Academic Degree

    • 修士(生命科学)(京都大学)
    • 博士(生命科学)(京都大学)

    Research History

    • From Aug. 2021, To Present
      Kyoto University Graduate School of Medicine, Department of Pharmacology, Assistant professor
    • From 2016, To Jul. 2021
      Kyoto University Graduate School of Medicine, Department of Pharmacology, Assistant professor
    • From 2016, To 2016
      RIKEN, Special Postdoctoral Researcher
    • From 2013, To 2016
      Research Fellowships for Young Scientists (PD), Japan Society for the Promotion of Science
    • From 2013, To 2015
      Osaka Bioscience Institute (OBI)
    • From 2010, To 2013
      Research Fellowships for Young Scientists (DC1), Japan Society for the Promotion of Science

    ID,URL

    researchmap URL

    list
      Last Updated :2022/06/28

      Research

      Research Topics, Overview of the research

      • Research Topics

        A role of structural plasticity in hippocampal memory.
      • Overview of the research

        New memory is formed after neuron establishes the new synapse or strengthens the synapse. Long-term potentiation(LTP) is a persistent increase in synaptic strength following high-frequency stimulation and it is widely considered as one major cellular mechanisms that underlies learning and memory. After LTP induction,the post synaptic spine also becomes larger. this is called structural LTP or sLTP. My research is to study a function of sLTP during memory formation in hippocampus.

      Research Interests

      • Imaging
      • Memory
      • Molecualr biology
      • Neuroscience

      Research Areas

      • Life sciences, Neuroscience - general, Synaptic plasticity
      • Life sciences, Neuroscience - general, Synaptic plasticity

      Papers

      • Synaptic plasticity during systems memory consolidation
        Akihiro Goto
        Neuroscience Research, Jun. 2022, Peer-reviewed, Lead author, Corresponding author
      • Shared and unique properties of place cells in anterior cingulate cortex and hippocampus
        Ayaka Bota; Akihiro Goto; Suzune Tsukamoto; Alexander Schmidt; Fred Wolf; Alessandro Luchetti; Junichi Nakai; Hajime Hirase; Yasunori Hayashi
        30 Mar. 2021
      • Stepwise synaptic plasticity events drive the early phase of memory consolidation
        Akihiro Goto; Ayaka Bota; Ken Miya; Jingbo Wang; Suzune Tsukamoto; Xinzhi Jiang; Daichi Hirai; Masanori Murayama; Tomoki Matsuda; Thomas J. McHugh; Takeharu Nagai; Yasunori Hayashi
        Science, 12 Nov. 2021, Peer-reviewed, Lead author
      • Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning
        Takashi Yamaguchi; Akihiro Goto; Ichiro Nakahara; Satoshi Yawata; Takatoshi Hikida; Michiyuki Matsuda; Kazuo Funabiki; Shigetada Nakanishi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2015, Peer-reviewed
      • Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice
        Akihiro Goto; Ichiro Nakahara; Takashi Yamaguchi; Yuji Kamioka; Kenta Sumiyama; Michiyuki Matsuda; Shigetada Nakanishi; Kazuo Funabiki
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2015, Peer-reviewed, Lead author
      • PKA modulation of Rac in neuronal cells
        Akihiro Goto; Yuji Kamioka; Michiyuki Matsuda
        FRONTIERS IN CELLULAR NEUROSCIENCE, Oct. 2014, Peer-reviewed, Lead author
      • Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells
        Takehiko Ueyama; Hirofumi Sakaguchi; Takashi Nakamura; Akihiro Goto; Shigefumi Morioka; Aya Shimizu; Kazuki Nakao; Yoshitaka Hishikawa; Yuzuru Ninoyu; Hidetoshi Kassai; Shiro Suetsugu; Takehiko Koji; Bernd Fritzsch; Shigenobu Yonemura; Yasuo Hisa; Michiyuki Matsuda; Atsu Aiba; Naoaki Saito
        JOURNAL OF CELL SCIENCE, May 2014, Peer-reviewed
      • Longest neurite-specific activation of Rap1B in hippocampal neurons contributes to polarity formation through RalA and Nore1A in addition to PI3-kinase
        Takeshi Nakamura; Sayaka Yasuda; Hiroyuki Nagai; Shingo Koinuma; So Morishita; Akihiro Goto; Tatsuo Kinashi; Naoyuki Wada
        Genes to Cells, Nov. 2013, Peer-reviewed
      • GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1
        Akihiro Goto; Kenta Sumiyama; Yuji Kamioka; Eiji Nakasyo; Keisuke Ito; Mitsuhiro Iwasaki; Hideki Enomoto; Michiyuki Matsuda
        Journal of Neuroscience, 13 Mar. 2013, Peer-reviewed, Lead author
      • Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells
        Akihiro Goto; Mikio Hoshino; Michiyuki Matsuda; Takeshi Nakamura
        MOLECULAR BIOLOGY OF THE CELL, May 2011, Peer-reviewed, Lead author

      Misc.

      • 光で記憶を消去する―記憶に睡眠が必要な理由を解明―
        後藤明弘
        神経科学ニュース (日本神経科学学会), Feb. 2022
      • New optogenetic tool to erase specific memory
        Akihiro Goto
        Photonics NEWS (Photonics Division), 10 May 2022
      • Inner ear hair cell-specific Cdc42-KO mice demonstrate progressive hearing loss by impaired actin turnover in stereocilia and apical junctions
        Takashi Nakamura; Takehiko Ueyama; Hirofumi Sakaguchi; Akihiro Goto; Shigefumi Morioka; Shigenobu Yonemura; Yasuo Hisa; Michiyuki Matsuda; Atsu Aiba; Naoaki Satio
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014
      • Rap1B plays an instructive role in neuronal polarization through RalA and Nore1A in addition to PI3-kinase
        Takeshi Nakamura; Akihiro Goto; Michiyuki Matsuda; Tatsuo Kinashi
        NEUROSCIENCE RESEARCH, 2010
      • FRET analysis of differences in signaling mechanism between dbcAMP- and NGF-induced neuritogenesis in PC12D cells
        Akihiro Goto; Takeshi Nakamura; Mikio Hoshino; Michiyuki Matsuda
        NEUROSCIENCE RESEARCH, 2010
      • Differences in signaling mechanism and morphological change between dbcAMP- and NGF-induced neuritogenesis in PC12D cells
        Akihiro Goto; Takeshi Nakamura; Michiyuki Matsuda
        NEUROSCIENCE RESEARCH, 2009

      Presentations

      • Stepwise synaptic plasticity events drive memory consolidation
        Akihiro Goto
        The 53rd Frontier Brain Science Seminar Sponsored by Research Center for Idling Brain Science (RCIBS), 14 Oct. 2021, Invited
      • A new optical method for identifying a time window of synaptic plasticity in hippocampus.
        Akihiro Goto
        Tokyo University of Science, 15 May 2019, Invited
      • A new optical method for erasing hippocampal LTP and memory.
        Akihiro Goto
        Niigata University, 02 Aug. 2018, Invited

      Media Coverage

      • Step by step consolidation
        Nature Reviews Neuroscience, (Research Highlights), 23, pages68–69, Dec. 2021
      • 光で記憶を消去する―記憶に睡眠が必要な理由を解明―
        日本神経科学学会, 神経科学トピックス, Dec. 2021, Pr
      • Using optogenetics, scientists pinpoint the location and timing of memory formation in mice
        STAT, STAT, Nov. 2021, Paper
      • News and Topics
        National Museum of Nature and Science, milsil, ページ33 (論文紹介), Jan. 2022, Paper
      • News Pickup
        NHK radio, Nらじ, ニュースピックアップに出演, 15 Dec. 2021, Media report
      • Erase aversive memory with light
        Yomiuri, Yomiuri (an evening newspaper), 8面に論文紹介とコメント掲載, 22 Nov. 2021, Paper
      • Pickup news
        テレビ朝日, Japanese TV program, performed by zoom, 19 Nov. 2021, Media report

      External funds: Kakenhi

      • マカク属サルfMRIによる高次脳機能制御の全脳マッピングと神経回路の因果的証明
        Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
        Medium-sized Section 51:Brain sciences and related fields
        Kyoto University
        肥後 剛康
        From 27 Oct. 2020, To 31 Mar. 2025, Granted
        サルfMRI;前頭前野;神経回路操作;霊長類;fMRI;高次脳機能
      • Revealing the function of offline LTP in memory consolidation
        Grant-in-Aid for Early-Career Scientists
        Basic Section 46010:Neuroscience-general-related
        Kyoto University
        後藤 明弘
        From 01 Apr. 2020, To 31 Mar. 2022, Granted
        LTP;シナプス可塑性;学習;海馬;CALI;Cofilin;offline-LTP;cofilin;記憶
      • Time window of NMDA receptor-dependent LTP in memory formation and consolidation
        Grant-in-Aid for Early-Career Scientists
        Basic Section 46010:Neuroscience-general-related
        Kyoto University
        Akihiro Goto
        From 01 Apr. 2018, To 31 Mar. 2020, Project Closed
        LTP;CALI;記憶の形成;cofilin;Cofilin;sLTP;SuperNova
      • A new optical mothod for defining an individuality of memory
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        後藤 明弘
        From 01 Apr. 2017, To 31 Mar. 2019, Project Closed
        in vivo カルシウムイメージング;cofilin;SuperNova;記憶;LTP;アセンブリ;コフィリン;Cofilin;内視顕微鏡;Supernova
      • Erasure of LTP and memory by light
        Grant-in-Aid for Scientific Research (C)
        Kyoto University;Institute of Physical and Chemical Research
        Akihiro Goto
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        cofilin;LTP;SuperNova;CALI;Cofilin;光操作;記憶の消去
      • 記憶固定化におけるシナプス可塑性の時空間解析
        Grant-in-Aid for Scientific Research (B)
        Basic Section 46010:Neuroscience-general-related
        Kyoto University
        後藤 明弘
        From 01 Apr. 2022, To 31 Mar. 2025, Adopted
      • シナプス可塑性による記憶回路のダイナミクス
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Kyoto University
        後藤 明弘
        From 16 Jun. 2022, To 31 Mar. 2024, Adopted
      list
        Last Updated :2022/06/28

        Education

        Teaching subject(s)

        • From Oct. 2017, To Mar. 2018
          薬理学
          Fall, 医学部
        • From Oct. 2017, To Mar. 2018
          薬理学演習
          Fall, 医学部
        • From Oct. 2017, To Mar. 2018
          薬理学実習
          Fall, 医学部
        • From Apr. 2018, To Sep. 2018
          薬理学
          Spring, 医学部
        • From Apr. 2018, To Sep. 2018
          薬理学演習
          Spring, 医学部
        • From Apr. 2018, To Sep. 2018
          薬理学実習
          Spring, 医学部
        • From Apr. 2019, To Sep. 2019
          薬理学
          Spring, 医学部
        • From Apr. 2019, To Sep. 2019
          薬理学演習
          Spring, 医学部
        • From Apr. 2019, To Sep. 2019
          薬理学実習
          Spring, 医学部
        list
          Last Updated :2022/06/28

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2017, To 31 Mar. 2019
            医学図書館図書連絡委員

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