Basic Information

Faculty

• 農学部

Professional Memberships

• 日本栄養食糧学会
• 日本農芸化学会

Academic Degree

• 農学修士(京都大学)
• 博士（農学）(京都大学)

Language of Instruction

• English

ID,URL

• J-Global ID

  200901075848638178

Research

Research Topics, Overview of the research

• Research Topics

  Studies on serine proteases involved in intestinal epithelial cell turnover.
  Studies on the interaction between class B scavenger receptor and fatty acids (or their related substances)

• Overview of the research

  I have been investigated whether distinct serine proteases (e.g., matriptase and granzyme A) are involved in intestinal epithelial turnover (i.e., cell detachment and death). I have recently examined the interaction between class B scavenger receptors (e.g., CD36 and SR-B1) and food odorants (e.g., distinct fatty aldehydes).

Research Interests

• 食品科学・栄養科学
• Food Science Nutrition Science

Research Areas

• Life sciences, Food sciences

Papers

• Binding Interaction Between Lauric Acid and Cluster of Differentiation 36 Underpinned by a Fluorescence- Intensifying Assay

  Satoshi Tsuzuki; Tatsuya Sugawara; Yuki Manabe; Masayuki Yamasaki; Tsutomu Sasaki

  Journal of Oleo Science, 2024

  
• Application of a novel fluorescence intensity assay: identification of distinct fatty acetates as volatile compounds that bind specifically to amino acid region 149-168 of a transmembrane receptor CD36.

  Satoshi Tsuzuki; Yusaku Kimoto; Keita Marui; Shinhye Lee; Kazuo Inoue; Tsutomu Sasaki

  Bioscience, biotechnology, and biochemistry, 21 Mar. 2022

  
• Assessment of direct binding interaction between CD36 and its potential lipid ligands using a peptide mimic of the receptor labeled with a fluorophore

  Satoshi TSUZUKI; Yusaku KIMOTO; Masayuki YAMASAKI; Tatsuya SUGAWARA; Yuki MANABE; Kazuo INOUE; Tsutomu SASAKI

  Biomedical Research, 21 Sep. 2021

  
• Higher Straight-Chain Aliphatic Aldehydes: Importance as Odor- Active Volatiles in Human Foods and Issues for Future Research

  TSUZUKI Satoshi

  Journal of Agricultural and Food Chemistry, May 2019, Peer-reviewed, Invited, Lead author, Corresponding author

  
• A novel role for scavenger receptor B1 as a contributor to the capture of specific volatile odorants in the nasal cavity

  Satoshi Tsuzuki; Yusaku Kimoto; Shinhye Lee; Tatsuya Sugawara; Yuki Manabe; Kazuo Inoue

  Biomedical Research (Japan), 2018, Peer-reviewed

  
• A role for scavenger receptor B1 as a captor of specific fatty acids in taste buds of circumvallate papillae

  Tsuzuki S; Lee S; Kimoto Y; Sugawara T; Manabe Y; Inoue K

  Biomedical Research, 2018, Peer-reviewed

  
• Assessment of direct interaction between CD36 and an oxidized glycerophospholipid species

  Satoshi Tsuzuki; Masayuki Yamasaki; Yuki Kozai; Tatsuya Sugawara; Yuki Manabe; Kazuo Inoue; Tohru Fushiki

  JOURNAL OF BIOCHEMISTRY, Sep. 2017, Peer-reviewed

  
• A Search for CD36 Ligands from Flavor Volatiles in Foods with an Aldehyde Moiety: Identification of Saturated Aliphatic Aldehydes with 9-16 Carbon Atoms as Potential Ligands of the Receptor

  Satoshi Tsuzuki; Takahiko Amitsuka; Tatsuya Okahashi; Yusaku Kimoto; Kazuo Inoue

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Aug. 2017, Peer-reviewed

  
• CD36 involvement in the olfactory perception of oleic aldehyde, an odour-active volatile compound, in mice

  Shinhye Lee; Satoshi Tsuzuki; Takahiko Amitsuka; Daisaku Masuda; Shizuya Yamashita; Kazuo Inoue

  BIOMEDICAL RESEARCH-TOKYO, 2017, Peer-reviewed

  
• A single aldehyde group can serve as a structural element for recognition by transmembrane protein CD36

  Satoshi Tsuzuki; Takahiko Amitsuka; Tatsuya Okahashi; Yuki Kozai; Shigenobu Matsumura; Kazuo Inoue; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2016, Peer-reviewed

  
• Identification of the odor-active volatile compound (Z,Z)-4,7-tridecadienal as a potential ligand for the transmembrane receptor CD36

  Satoshi Tsuzuki; Takahiko Amitsuka; Tatsuya Okahashi; Yuki Kozai; Masayuki Yamasaki; Kazuo Inoue; Tohru Fushiki

  BIOMEDICAL RESEARCH-TOKYO, 2016, Peer-reviewed

  
• Immunohistochemical localization of fatty acid transporters and MCT1 in the sebaceous glands of mouse skin

  Miao Zheng; Shinhye Lee; Satoshi Tsuzuki; Kazuo Inoue; Daisaku Masuda; Shizuya Yamashita; Toshihiko Iwanaga

  BIOMEDICAL RESEARCH-TOKYO, 2016, Peer-reviewed

  
• Expression of CD36 by Olfactory Receptor Cells and Its Abundance on the Epithelial Surface in Mice

  Shinhye Lee; Ai Eguchi; Satoshi Tsuzuki; Shigenobu Matsumura; Kazuo Inoue; Toshihiko Iwanaga; Daisaku Masuda; Shizuya Yamashita; Tohru Fushiki

  PLOS ONE, Jul. 2015, Peer-reviewed

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• Mechanisms Involved in Guiding the Preference for Fat Emulsion Differ Depending on the Concentration

  Kazuhiro Sakamoto; Shigenobu Matsumura; Yoko Okafuji; Ai Eguchi; Shinhye Lee; Shin-ichi Adachi; Mina Fujitani; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Jun. 2015, Peer-reviewed

  
• The opioid system majorly contributes to preference for fat emulsions but not sucrose solutions in mice

  Kazuhiro Sakamoto; Tatsuya Okahashi; Shigenobu Matsumura; Yoko Okafuji; Shin-ichi Adachi; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Apr. 2015, Peer-reviewed

  
• A role of CD36 in the perception of an oxidised phospholipid species in mice

  Shinhye Lee; Ai Eguchi; Kazuhiro Sakamoto; Shigenobu Matsumura; Satoshi Tsuzuki; Kazuo Inoue; Daisaku Masuda; Shizuya Yamashita; Tohru Fushiki

  BIOMEDICAL RESEARCH-TOKYO, 2015, Peer-reviewed

  
• The opioid system contributes to the acquisition of reinforcement for dietary fat but is not required for its maintenance

  Kazuhiro Sakamoto; Shigenobu Matsumura; Yoko Okafuji; Ai Eguchi; Takeshi Yoneda; Takafumi Mizushige; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  PHYSIOLOGY & BEHAVIOR, Jan. 2015, Peer-reviewed

  
• Behavioral palatability of dietary fatty acids correlates with the intracellular calcium ion levels induced by the fatty acids in GPR120-expressing cells

  Shin-ichi Adachi; Ai Eguchi; Kazuhiro Sakamoto; Hiroki Asano; Yasuko Manabe; Shigenobu Matsumura; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  BIOMEDICAL RESEARCH-TOKYO, Dec. 2014, Peer-reviewed

  
• A Study of an Aroma Extraction Method and Evaluation of the Aroma Extract Contribution to the Palatability and Reinforcement Effect of Dried Bonito Using Mice

  Takahiko Amitsuka; Maya Okamura; Hiroko Shibashi; Naoto Yamamoto; Tsukasa Saito; Takashi Nammoku; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Oct. 2014, Peer-reviewed

  
• Further validation of unsaturated long-chain fatty acids as inhibitors for oxidized low-density lipoprotein binding to CD36 via assays with synthetic CD36 peptide-cross-linked plates

  Yuki Kozai; Satoshi Tsuzuki; Marie Takai; Ai Eguchi; Shigenobu Matsumura; Kazuo Inoue; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2014, Peer-reviewed

  
• Increased Levels of Extracellular Dopamine in the Nucleus Accumbens and Amygdala of Rats by Ingesting a Low Concentration of a Long-Chain Fatty Acid

  Shin-ichi Adachi; Yuki Endo; Takafumi Mizushige; Satoshi Tsuzuki; Shigenobu Matsumura; Kazuo Inoue; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 2013, Peer-reviewed

  
• Assessment of Key Amino-Acid Residues of CD36 in Specific Binding Interaction with an Oxidized Low-Density Lipoprotein

  Marie Takai; Satoshi Tsuzuki; Yukari Matsuno; Yuki Kozai; Ai Eguchi; Shigenobu Matsumura; Kazuo Inoue; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2013, Peer-reviewed

  
• Roles of CUB and LDL receptor class A domain repeats of a transmembrane serine protease matriptase in its zymogen activation

  Kuniyo Inouye; Marie Tomoishi; Makoto Yasumoto; Yuka Miyake; Kenji Kojima; Satoshi Tsuzuki; Tohru Fushiki

  JOURNAL OF BIOCHEMISTRY, Jan. 2013, Peer-reviewed

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• A synthetic peptide-based assay system for detecting binding between CD36 and an oxidized low-density lipoprotein

  Satoshi Tsuzuki; Marie Takai; Yukari Matsuno; Yuki Kozai; Maiko Fujioka; Kozue Kamei; Hitomi Inagaki; Ai Eguchi; Shigenobu Matsumura; Kazuo Inoue; Tohru Fushiki

  Bioscience, Biotechnology and Biochemistry, 2013, Peer-reviewed

  
• Dietary fat ingestion activates beta-endorphin neurons in the hypothalamus

  Shigenobu Matsumura; Ai Eguchi; Yoko Okafuji; Sotaro Tatsu; Takafumi Mizushige; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  FEBS LETTERS, Apr. 2012, Peer-reviewed

  
• A recombinant catalytic domain of matriptase induces detachment and apoptosis of small-intestinal epithelial IEC-6 cells cultured on laminin-coated surface

  Seiya Mochida; Satoshi Tsuzuki; Kuniyo Inouye; Tohru Fushiki

  JOURNAL OF BIOCHEMISTRY, Dec. 2010, Peer-reviewed

  
• Identification of the Matriptase Second CUB Domain as the Secondary Site for Interaction with Hepatocyte Growth Factor Activator Inhibitor Type-1

  Kuniyo Inouye; Satoshi Tsuzuki; Makoto Yasumoto; Kenji Kojima; Seiya Mochida; Tohru Fushiki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2010, Peer-reviewed

  
• Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells

  Yumiko Yoshikawa; Hirofumi Hirayasu; Satoshi Tsuzuki; Tohru Fushiki

  CYTOTECHNOLOGY, Aug. 2010, Peer-reviewed

  
• Effect of an intraduodenal injection of fat on the activities of the adrenal efferent sympathetic nerve and the gastric efferent parasympathetic nerve in urethane-anesthetized rats

  Shigenobu Matsumura; Ai Eguchi; Nobuhide Kitabayashi; Mamoru Tanida; Jiao Shen; Yuko Horii; Katsuya Nagai; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  NEUROSCIENCE RESEARCH, Jul. 2010, Peer-reviewed

  
• The Structural Requirements of Matriptase in Its Ectodomain Release in Polarized Epithelial Cells

  Satoshi Tsuzuki; Nobuhito Murai; Yuka Miyake; Kuniyo Inouye; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jun. 2010, Peer-reviewed

  
• Matriptase Does Not Require Hepatocyte Growth Factor Activator Inhibitor Type-1 for Activation in an Epithelial Cell Expression Model

  Yuka Miyake; Satoshi Tsuzuki; Tohru Fushiki; Kuniyo Inouye

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Apr. 2010, Peer-reviewed

  
• The optimal activity of a pseudozymogen form of recombinant matriptase under the mildly acidic pH and low ionic strength conditions

  Kuniyo Inouye; Makoto Yasumoto; Satoshi Tsuzuki; Seiya Mochida; Tohru Fushiki

  JOURNAL OF BIOCHEMISTRY, Apr. 2010, Peer-reviewed

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• Intragastric infusion of glucose enhances the rewarding effect of sorbitol fatty acid ester ingestion as measured by conditioned place preference in mice

  Shigenobu Matsumura; Takeshi Yoneda; Syoji Aki; Ai Eguchi; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  PHYSIOLOGY & BEHAVIOR, Mar. 2010, Peer-reviewed

  
• The role of asparagine-linked glycosylation site on the catalytic domain of matriptase in its zymogen activation

  Yuka Miyake; Satoshi Tsuzuki; Seiya Mochida; Tohru Fushiki; Kuniyo Inouye

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Jan. 2010, Peer-reviewed

  
• The Occurrence of Matriptase C-Terminal Fragments on the Apical and Basolateral Sides of Madin-Darby Canine Kidney Epithelial Cells

  Satoshi Tsuzuki; Yuka Miyake; Kuniyo Inouye; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Nov. 2009, Peer-reviewed

  
• Secreted expression of pseudozymogen forms of recombinant matriptase in Pichia pastoris

  Seiya Mochida; Satoshi Tsuzuki; Makoto Yasumoto; Kuniyo Inouye; Tohru Fushiki

  ENZYME AND MICROBIAL TECHNOLOGY, Oct. 2009, Peer-reviewed

  
• Activation of a Membrane-Bound Serine Protease Matriptase on the Cell Surface

  Yuka Miyake; Makoto Yasumoto; Satoshi Tsuzuki; Tohru Fushiki; Kuniyo Inouye

  JOURNAL OF BIOCHEMISTRY, Aug. 2009, Peer-reviewed

  
• Requirement of the activity of hepatocyte growth factor activator inhibitor type 1 for the extracellular appearance of a transmembrane serine protease matriptase in monkey kidney COS-1 cells

  Yuka Miyake; Satoshi Tsuzuki; Makoto Yasumoto; Tohru Fushiki; Kuniyo Inouye

  CYTOTECHNOLOGY, Jul. 2009, Peer-reviewed

  
• Role of the Stem Domain of Matriptase in the Interaction with its Physiological Inhibitor, Hepatocyte Growth Factor Activator Inhibitor Type I

  Kenji Kojima; Satoshi Tsuzuki; Tohru Fushiki; Kuniyo Inouye

  JOURNAL OF BIOCHEMISTRY, Jun. 2009, Peer-reviewed

  
• Preference for dietary fat induced by release of beta-endorphin in rats

  Takafumi Mizushige; Katsuyoshi Saitoh; Yasuko Manabe; Taichi Nishizuka; Yuichi Taka; Ai Eguchi; Takeshi Yoneda; Shigenobu Matsumura; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  LIFE SCIENCES, May 2009, Peer-reviewed

  
• Involvement of the cytoplasmic juxtamembrane region of matriptase in its exclusive localization to the basolateral membrane domain of Madin-Darby canine kidney epithelial cells

  Nobuhito Murai; Yuka Miyake; Satoshi Tsuzuki; Kuniyo Inouye; Tohru Fushiki

  CYTOTECHNOLOGY, Apr. 2009, Peer-reviewed

  
• Assessing palatability of long-chain fatty acids from the licking behavior of BALB/c mice

  Takeshi Yoneda; Katsuyoshi Saitou; Hiroki Asano; Takafumi Mizushige; Shigenobu Matsumura; Ai Eguchi; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  PHYSIOLOGY & BEHAVIOR, Mar. 2009, Peer-reviewed

  
• The Activity of a Type II Transmembrane Serine Protease, Matriptase, Is Dependent Solely on the Catalytic Domain

  Kenji Kojima; Satoshi Tsuzuki; Tohru Fushiki; Kuniyo Inouye

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Feb. 2009, Peer-reviewed

  
• Development of an In Vitro System for Screening the Ligands of a Membrane Glycoprotein CD36

  Hitomi Inagaki; Satoshi Tsuzuki; Takashi. Iino; Kazuo Inoue; Tohru Fushiki

  ANIMAL CELL TECHNOLOGY: BASIC AND APPLIED ASPECTS, VOL 15, 2009, Peer-reviewed

  
• RECOGNITION OF DIETARY FAT IN THE ORAL CAVITY

  Shigenobu Matsumura; Takafumi Mizushige; Takeshi Yoneda; Ai Eguchi; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009, Peer-reviewed

  
• リンパ球セリンプロテアーゼグランザイムAによる腸管上皮細胞 の剥離作用と硫酸化多糖による抑制

  都築 巧

  日本食物繊維学会 第１４回学術集会, 2009, Peer-reviewed

  
• Colocalization of GPR120 with phospholipase-C beta 2 and alpha-gustducin in the taste bud cells in mice

  Shigenobu Matsumura; Ai Eguchi; Takafumi Mizushige; Nobuhide Kitabayashi; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  NEUROSCIENCE LETTERS, Jan. 2009, Peer-reviewed

  
• Contribution of gustation to the palatability of linoleic acid

  Katsuyoshi Saitou; Takeshi Yoneda; Takafumi Mizushige; Hiroki Asano; Maya Okamura; Shigenobu Matsumura; Ai Eguchi; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  PHYSIOLOGY & BEHAVIOR, Jan. 2009, Peer-reviewed

  
• Carrageenan inhibits granzyme A-induced detachment of and interleukin-8 release from alveolar epithelial A549 cells

  Yumiko Yoshikawa; Hirofumi Hirayasu; Satoshi Tsuzuki; Tohru Fushiki

  CYTOTECHNOLOGY, Oct. 2008, Peer-reviewed

  
• Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release

  Yumiko Yoshikawa; Hirofumi Hirayasu; Satoshi Tsuzuki; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 2008, Peer-reviewed

  
• A lymphocyte serine protease granzyme A causes detachment of a small-intestinal epithelial cell line (IEC-6)

  Hirofumi Hirayasu; Yumiko Yoshikawa; Satoshi Tsuzuki; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 2008, Peer-reviewed

  
• Mercaptoacetate inhibition of fatty acid beta-oxidation attenuates the oral acceptance of fat in BALB/c mice

  Shigenobu Matsumura; Katsuyoshi Saitou; Takashi Miyaki; Takeshi Yoneda; Takafumi Mizushige; Ai Eguchi; Tetsuro Shibakusa; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Jul. 2008, Peer-reviewed

  
• Development of an in vitro system for screening the ligands of a membrane glycoprotein CD36

  Hitomi Inagaki; Satoshi Tsuzuki; Takashi Iino; Kazuo Inoue; Tohru Fushiki

  CYTOTECHNOLOGY, Jun. 2008, Peer-reviewed

  
• Gタンパク共役型脂肪酸受容体GPR120のリガンドスクリーニング

  江口 愛; 眞鍋 康子; 伊井野 貴史; 都築 巧; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, Apr. 2008

  
• Roles of functional and structural domains of hepatocyte growth factor activator inhibitor type 1 in the inhibition of matriptase

  Kenji Kojima; Satoshi Tsuzuki; Tohru Fushiki; Kuniyo Inouye

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2008, Peer-reviewed

  
• Reinforcing effect for corn oil stimulus was concentration dependent in an operant task in mice

  Takeshi Yoneda; Yuichi Taka; Maya Okamura; Takafumi Mizushige; Shigenobu Matsumura; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  LIFE SCIENCES, Nov. 2007, Peer-reviewed

  
• The palatability of corn oil and linoleic acid to mice as measured by short-term two-bottle choice and licking tests

  Takeshi Yoneda; Katsuyoshi Saitou; Takafumi Mizushige; Shigenobu Matsumura; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  PHYSIOLOGY & BEHAVIOR, Jun. 2007, Peer-reviewed

  
• GPR expression in the rat taste bud relating to fatty acid sensing

  Shigenobu Matsumura; Takafumi Mizushige; Takeshi Yoneda; Toshihiko Iwanaga; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  BIOMEDICAL RESEARCH-TOKYO, Feb. 2007, Peer-reviewed

  
• Daily increase of fat ingestion mediated via mu-opioid receptor signaling pathway

  Takafumi Mizushige; Shigenobu Matsumura; Takeshi Yoneda; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  Biomedical Research, 10 Jan. 2007, Peer-reviewed

  
• A role of a lymphocyte tryptase, granzyme a, in experimental ulcerative colitis

  Hirofumi Hirayasu; Yumiko Yoshikawa; Satoshi Tsuzuki; Tohru Fushiki

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jan. 2007, Peer-reviewed

  
• POMC and orexin mRNA expressions induced by anticipation of a corn-oil emulsion feeding are maintained at the high levels until oil ingestion

  Takafumi Mizushige; Takayuki Kawai; Shigenobu Matsumura; Takeshi Yoneda; Teruo Kawada; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  BIOMEDICAL RESEARCH-TOKYO, Oct. 2006, Peer-reviewed

  
• Sulfated polysaccharides derived from dietary seaweeds increase the esterase activity of a lymphocyte tryptase, granzyme A

  H Hirayasu; Y Yoshikawa; S Tsuzuki; T Fushiki

  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Dec. 2005, Peer-reviewed

  
• Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytes

  S Tsuzuki; N Murai; Y Miyake; K Inouye; H Hirayasu; T Iwanaga; T Fushiki

  BIOCHEMICAL JOURNAL, Jun. 2005, Peer-reviewed

  
• Molecular Nutritional Studies on Serine Proteases and Their Inhibitors That Regulate Cell Turnover of Intestinal Mucosal Epithelium : Young Investigator Award of the 2004's JSNFS

  TSUZUKI Satoshi

  Eiyo To Shokuryo, 10 Dec. 2004

  
• Purification and identification of a binding protein for pancreatic secretory trypsin inhibitor: a novel role of the inhibitor as an anti-granzyme A

  S Tsuzuki; Y Kokado; S Satomi; Y Yamasaki; H Hirayasu; T Iwanaga; T Fushiki

  BIOCHEMICAL JOURNAL, May 2003, Peer-reviewed

  
• Inhibition of membrane-type serine protease 1/matriptase by natural and synthetic protease inhibitors

  Y Yamasaki; S Satomi; N Murai; S Tsuzuki; T Fushiki

  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Feb. 2003, Peer-reviewed

  
• 上皮細胞の代謝を制御する膜結合性セリンプロテアーゼMT-SPI（共著）

  都築 巧

  化学と生物（学会出版センター）,40(9), 564-565, 2002, Peer-reviewed

  
• A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover

  S Satomi; Y Yamasaki; S Tsuzuki; Y Hitomi; T Iwanaga; T Fushiki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2001, Peer-reviewed

  
• Angiotensin receptors: Molecular biology and signalling

  T Inagami; Y Kambayashi; T Ichiki; S Tsuzuki; S Eguchi; T Yamakawa

  CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, Jul. 1999, Peer-reviewed

  
• CCK regulation of monitor peptide gene expression in pancreatic acinar AR42J cells.

  Toshi Kinouchi; Satoshi Tsuzuki; Chieko Minami; Yoshihiro Hayashi; Etsuro Sugimoto; Tohru Fushiki

  ANIMAL CELL TECHNOLOGY: CHALLENGES FOR THE 21ST CENTURY, 1999, Peer-reviewed

  
• Angiotensin II receptors AT(1) and AT(2) - New mechanisms of signaling and antagonistic effects of AT(1) and AT(2)

  T Inagami; S Eguchi; S Tsuzuki; T Ichiki

  JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION, Oct. 1997, Peer-reviewed

  
• Long-term consumption of an amino acid diet reduces the pancreatic enzyme secretion response to a trypsin inhibitor in rats

  Y Miura; H Murayama; S Tsuzuki; E Sugimoto; K Torii; T Fushiki

  JOURNAL OF NUTRITION, Jul. 1997, Peer-reviewed

  
• Mechanisms of CCK regulation of monitor peptide mRNA expression in pancreatic acinar AR42J cells

  Toshi Kinouchi; Satoshi Tsuzuki; Chieko Minami; Yoshihiro Hayashi; Etsuro Sugimoto; Tohru Fushiki

  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Apr. 1997, Peer-reviewed

  
• Mechanisms of CCK regulation of monitor peptide mRNA expression in pancreatic acinar AR42J cells

  T Kinouchi; Satoshi Tsuzuki; C Minami; Y Hayashi; E Sugimoto; T Fushiki

  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Apr. 1997, Peer-reviewed

  
• Inhibition of cell proliferation and activation of protein tyrosine phosphatase mediated by angiotensin II type 2 (AT(2)) receptor in R3T3 cells

  S Tsuzuki; S Eguchi; T Inagami

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1996, Peer-reviewed

  
• Angiotensin II type 2 receptor inhibits cell proliferation and activates tyrosine phosphatase

  S Tsuzuki; T Matoba; S Eguchi; T Inagami

  HYPERTENSION, Nov. 1996, Peer-reviewed

  
• LOCALIZATION OF THE GENES ENCODING THE 3 RAT ANGIOTENSIN-II RECEPTORS, AGTR1A, AGTR1B, AGTR2, AND THE HUMAN AGTR2 RECEPTOR RESPECTIVELY TO RAT CHROMOSOMES 17Q12, 2Q24 AND XQ34, AND THE HUMAN XQ22

  F TISSIR; M RIVIERE; DF GUO; Satoshi Tsuzuki; T INAGAMI; G LEVAN; J SZPIRER; C SZPIRER

  CYTOGENETICS AND CELL GENETICS, 1995, Peer-reviewed

  
• Cloning, expression and regulation of angiotensin II receptors

  T INAGAMI; Y YAMANO; S BARDHAN; S CHAKI; DF GUO; K OHYAMA; Y KAMBAYASHI; K TAKAHASHI; T ICHIKI; Satoshi Tsuzuki; H TANG

  TISSUE RENIN-ANGIOTENSIN SYSTEMS, 1995, Peer-reviewed

  
• MOLECULAR-CLONING AND EXPRESSION OF THE GENE ENCODING HUMAN ANGIOTENSIN-II TYPE-2 RECEPTOR

  S TSUZUKI; T ICHIKI; H NAKAKUBO; Y KITAMI; DF GUO; H SHIRAI; T INAGAMI

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 1994, Peer-reviewed

  
• MOLECULAR-CLONING OF A NOVEL ANGIOTENSIN-II RECEPTOR ISOFORM INVOLVED IN PHOSPHOTYROSINE PHOSPHATASE INHIBITION

  Y KAMBAYASHI; S BARDHAN; K TAKAHASHI; S TSUZUKI; H INUI; T HAMAKUBO; T INAGAMI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 1993, Peer-reviewed

  
• MOLECULAR-CLONING AND CHARACTERIZATION OF GENES ENCODING RAT PANCREATIC CHOLECYSTOKININ (CCK)-RELEASING PEPTIDE (MONITOR PEPTIDE) AND PANCREATIC SECRETORY TRYPSIN-INHIBITOR (PSTI)

  Satoshi Tsuzuki; Y MIURA; T FUSHIKI; T OOMORI; T SATOH; Y NATORI; E SUGIMOTO

  BIOCHIMICA ET BIOPHYSICA ACTA, Sep. 1992, Peer-reviewed

  
• MONITOR PEPTIDE GENE-EXPRESSION IS INCREASED BY EXOGENOUS CCK IN THE RAT PANCREAS AND IN A RAT PANCREATIC ACINAR CELL-LINE (AR4-2J)

  S TSUZUKI; A KONDO; T FUSHIKI; E SUGIMOTO

  FEBS LETTERS, Aug. 1992, Peer-reviewed

  
• EFFECT OF A HIGH-PROTEIN DIET ON THE GENE-EXPRESSION OF A TRYPSIN-SENSITIVE, CHOLECYSTOKININ-RELEASING PEPTIDE (MONITOR PEPTIDE) IN THE PANCREAS

  S TSUZUKI; T FUSHIKI; A KONDO; H MURAYAMA; E SUGIMOTO

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Jul. 1991, Peer-reviewed

  
• EFFECT OF NEURAL BLOCKERS AND CR-1392 ON THE PANCREATIC-ENZYME SECRETION IN RESPONSE TO SOYBEAN TRYPSIN-INHIBITOR AND HYDROCHLORIC-ACID

  T FUSHIKI; S TSUZUKI; S FUKUOKA; M TAKADA; H MURAYAMA; K IWAI; E SUGIMOTO

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Sep. 1989, Peer-reviewed

  

Misc.

• 上皮細胞の代謝を制御する膜結合型セリンプロテアーゼMT-SP1 : 組織修復やアポトーシスにも関与する一方、癌の浸潤も容易にさせてしまう側面も

  都築 巧; 伏木 亨

  化学と生物, 25 Sep. 2002

  
• CD36 ligand activities of flavor volatiles in foods with an aldehyde moiety: Identification of saturated aliphatic aldehydes with 9-16 carbon atoms as potential ligands of the receptor

  Satoshi Tsuzuki; Takahiko Amitsuka; Tatsuya Okahashi; Yusaku Kimoto; Kazuo Inoue

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2018

  
• 哺乳類の嗅覚系における膜貫通受容体CD36の発現

  LEE Shinhye; 江口愛; 都築巧; 松村成暢; 井上和生; 岩永敏彦; 増田大作; 山下静也; 伏木亨

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2017

  
• 脂肪関連物質のモデルCD36ペプチドヘの結合能の評価

  香西裕貴; 網塚貴彦; 高井まりえ; 都築巧; 江口愛; 松村成暢; 井上和生; 伏木亨

  日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集, 26 Sep. 2014

  
• 脂質と糖質の嗜好性におけるopioidの寄与の違い

  坂本和洋; 岡橋達也; 岡藤洋子; 松村成暢; 都築巧; 井上和生; 伏木亨

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• 油脂の嗜好性形成過程におけるオピオイド系の作用に匂いの質が与える影響

  岡藤洋子; 坂本和洋; 松村成暢; 都築巧; 井上和生; 伏木亨

  日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集, 01 Oct. 2013

  
• 異なる濃度の油脂における嗜好メカニズムの違い

  坂本和洋; 松村成暢; 岡藤洋子; 江口愛; 李信恵; 都築巧; 井上和生; 伏木亨

  日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集, 01 Oct. 2013

  
• 脳内オピオイドが油脂の摂取行動に与える影響

  岡藤 洋子; 松村 成暢; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, Apr. 2012

  
• 脂肪酸代謝阻害が油脂摂取時における側坐核ドーパミン遊離量に与える影響

  安達 真一; 遠藤 祐紀; 松村 成暢; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, Apr. 2011

  
• Palatability of long-chain fatty acids assessing from the licking behavior of BALB/c mice

  Takeshi Yoneda; Katsuyoshi Saitou; Hiroki Asano; Takafumi Mizushige; Shigenobu Matsumura; Ai Eguchi; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  CHEMICAL SENSES, Jan. 2011

  
• コーン油十二指腸投与が胃副交感神経活動に与える影響

  松村成暢; 江口愛; 北林伸英; 谷田守; SHEN Jiao; 堀井裕子; 永井克也; 都築巧; 井上和生; 伏木亨

  日本栄養・食糧学会大会講演要旨集, 01 May 2010, Peer-reviewed

  
• 脂肪代替物質スクリーニングのための無細胞アッセイ系の構築

  松野由香里; 松野由香里; 藤岡麻依子; 藤岡麻依子; 亀井梢; 亀井梢; 稲垣仁美; 稲垣仁美; 都築巧; 都築巧; 井上和生; 井上和生; 伏木亨; 伏木亨

  日本農芸化学会大会講演要旨集, 05 Mar. 2010, Peer-reviewed

  
• Matriptaseのstem領域においてHAI-1(hepatocyte growth factor activator inhibitor type 1)との相互作用を増強させる部位の同定

  都築 巧

  日本農芸化学会２０１０年度大会, 2010, Peer-reviewed

  
• MatriptaseはMMPsを介してラット小腸由来IEC-6細胞のアポトーシスを誘導する

  都築 巧

  日本農芸化学会２０１０年度大会, 2010, Peer-reviewed

  
• CD36 and GPR120 and Licking Behavior Corresponding to the Ligands in Mice

  Shigenobu Matsumura; Takeshi Yoneda; Ai Eguchi; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Tohru Fushiki

  CHEMICAL SENSES, Sep. 2009

  
• 舌上における脂肪酸をリガンドとするGタンパク共役型受容体の発現

  松村 成暢; 江口 愛; 水重 貴文; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, May 2009, Peer-reviewed

  
• ノルアドレナリン作動性神経による持久運動時のエネルギー代謝調節

  下須賀康爾; 宮木貴志; 北岡龍; 藤川哲平; 松村成暢; 都築巧; 井上和生; 伏木亨

  日本栄養・食糧学会大会講演要旨集, 01 May 2009, Peer-reviewed

  
• 持久運動時の中枢性エネルギー代謝調節機構の解明

  北岡龍; 藤川哲兵; 下須賀康爾; 宮木貴志; 都築巧; 井上和生; 伏木亨

  日本栄養・食糧学会大会講演要旨集, 01 May 2009, Peer-reviewed

  
• The Palatability of Fatty Acids to Mice as Measured by Short-Term Two-Bottle Choice and Licking Tests

  T. Yoneda; K. Saitou; T. Mizushige; S. Matsumura; Y. Manabe; S. Tsuzuki; K. Inoue; T. Fushiki

  CHEMICAL SENSES, Mar. 2009

  
• 酵母Pichia pastorisを用いたmatriptase触媒ドメインの生産

  都築 巧

  日本農芸化学会２００９年度大会, 2009, Peer-reviewed

  
• matriptaseのLDLRAドメインのHAI-1との相互作用における意義

  都築 巧

  日本農芸化学会２００９年度大会, 2009, Peer-reviewed

  
• 硫酸化多糖によるグランザイムAの機能調節

  都築 巧

  第６３回日本栄養・食糧学会大会, 2009, Peer-reviewed

  
• 肝細胞増殖因子アクチベーター阻害物質I型（HAI-1）によるマトリプターゼの阻害機構

  都築 巧

  日本生化学会２００９年度大会シンポジウム, 2009, Peer-reviewed

  
• GPR Expression in the Rat Taste Bud Relating to Fatty Acid Sensing

  Shigenobu Matsumura; Takafumi Mizushige; Takeshi Yoneda; Ai Eguchi; Yasuko Manabe; Satoshi Tsuzuki; Kazuo Inoue; Toshihiko Iwanaga; Tohru Fushiki

  CHEMICAL SENSES, Oct. 2008

  
• 油脂の口腔内刺激が報酬効果に与える影響の検討

  東海林 亜希; 米田 武志; 松村 成暢; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, 01 Apr. 2008, Peer-reviewed

  
• 嗅覚遮断マウスを用いた油脂の嗜好性評価

  浅野 裕基; 齋藤 勝義; 米田 武志; 岡村 摩耶; 松村 成暢; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, 01 Apr. 2008, Peer-reviewed

  
• 油脂の報酬効果に対するカロリーの関与の検討

  松村成暢; 米田武志; 岡村摩耶; 斎藤勝義; 東海林亜希; 都築巧; 井上和生; 伏木亨

  日本農芸化学会大会講演要旨集, 05 Mar. 2008, Peer-reviewed

  
• コーン油およびリノール酸の口腔内刺激に基づく嗜好性評価

  齋藤勝義; 米田武志; 岡村摩耶; 浅野裕基; 松村成暢; 都築巧; 井上和生; 伏木亨

  日本農芸化学会大会講演要旨集, 05 Mar. 2008, Peer-reviewed

  
• Mice discriminate the concentration of dietary oil in the oral cavity

  K. Saito; T. Yoneda; T. Mizushige; S. Matsumura; Y. Manabe; S. Tsuzuki; K. Inoue; T. Fushiki

  CHEMICAL SENSES, Feb. 2008

  
• GPR expression in the rat taste bud relating to fatty acid sensing

  S. Matsumura; T. Mizushige; T. Yoneda; Y. Manabe; S. Tsuzuki; K. Inoue; T. Iwanaga; T. Fushiki

  CHEMICAL SENSES, Feb. 2008

  
• The palatability of linoleic acid to mice as measured by licking tests

  T. Yoneda; K. Saitou; T. Mizushige; S. Matsumura; Y. Manabe; S. Tsuzuki; K. Inoue; T. Fushiki

  CHEMICAL SENSES, Feb. 2008

  
• P-005 GPR expression in the rat taste bud

  Matsumura Shigenobu; Mizushige Takafumi; Yoneda Takeshi; Manabe Yasuko; Tsuzuki Satoshi; Inoue Kazuo; Iwanaga Toshihiko; Fushiki Tohru

  The Japanese journal of taste and smell research, Dec. 2007

  
• P-035 The palatability of linoleic acid to mice as measured by licking tests

  Yoneda Takeshi; Saitou Katsuyoshi; Mizushige Takafumi; Matsumura Shigenobu; Manabe Yasuko; Tsuzuki Satoshi; Inoue Kazuo; Fushiki Tohru

  The Japanese journal of taste and smell research, Dec. 2007

  
• P-036 Mice discriminate the concentration of dietary oil in the oral cavity

  Saito Katsuyoshi; Yoneda Takeshi; Mizushige Takafumi; Matsumura Shigenobu; Manabe Yasuko; Tsuzuki Satoshi; Inoue Kazuo; Fushiki Tohru

  The Japanese journal of taste and smell research, Dec. 2007

  
• 舌上におけるGタンパク共役型脂肪酸受容体の発現

  松村 成暢; 水重 貴文; 米田 武志; 眞鍋 康子; 都築 巧; 井上 和生; 岩永 敏彦; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, Apr. 2007

  
• 口腔内刺激に依存した油脂の嗜好性評価

  齋藤 勝義; 米田 武志; 水重 貴文; 安達 真一; 松村 成暢; 眞鍋 康子; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, Apr. 2007

  
• 脂肪酸は口腔内で油脂を認識する手がかりとなる

  米田 武志; 斉藤 勝義; 水重 貴文; 松村 成暢; 眞鍋 康子; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, Apr. 2007

  
• 油脂の嗜好性および期待感の強化に対するOpioidの関与

  水重 貴文; 齋藤 勝義; 松村 成暢; 米田 武志; 真鍋 康子; 都築 巧; 井上 和生; 伏木 亨

  日本栄養・食糧学会大会講演要旨集, Apr. 2007

  
• Comparisons of long-and medium chain triacylglycerol as an induces of reinforcing effect in mice

  T. Yoneda; M. Okamura; A. Shoji; T. Mizushige; S. Matsumura; S. Tsuzuki; K. Inoue; T. Fushiki

  CHEMICAL SENSES, Feb. 2007

  
• The effect of naloxone on licking behavior of rat ingesting corn oil emulsion

  K. Saito; T. Mizushige; S. Adachi; T. Yoneda; S. Matsumura; S. Tsuzuki; K. Inoue; T. Fushiki

  CHEMICAL SENSES, Feb. 2007

  
• P-045. Comparisons of long- and medium chain triacylglycerol as an induces of reinforcing effect in mice

  Yoneda Takeshi; Okamura Maya; Shoji Aki; Mizushige Takafumi; Matsumura Shigenobu; Tsuzuki Satoshi; Inoue Kazuo; Fushiki Tohru

  The Japanese journal of taste and smell research, Dec. 2006

  
• P-047. The effect of naloxone on licking behavior of rat ingesting corn oil emulsion

  Saito Katsuyoshi; Mizushige Takafumi; Adachi Shinichi; Yoneda Takeshi; Matsumura Shigenobu; Tsuzuki Satoshi; Inoue Kazuo; Fushiki Tohru

  The Japanese journal of taste and smell research, Dec. 2006

  
• Possible feedback mechanisms involved in exocrine pancreatic secretion in pigs and rats

  SG Pierzynowski; S Jakob; KH Erlwanger; S Tsuzuki; T Fushiki; PC Gregory; JAM Botermans; BW Westrom

  BIOLOGY OF THE PANCREAS IN GROWING ANIMALS, 1999, Peer-reviewed

  
• Feedback regulation of pancreatic secretion

  T Fushiki; S Tsuzuki; SG Pierzynowski

  BIOLOGY OF THE PANCREAS IN GROWING ANIMALS, 1999, Peer-reviewed

  

Awards

• 2004

  Japan Society of Nutrition and Food Science, 日本栄養・食糧学会奨励賞
• 2018

  American Chemical Society, Journal of Agricultural and Food Chemistry Research Article of the Year Award (AGFD Division)

External funds: Kakenhi

• Elucidation of the mechanisms on the capture and recognition of food odorants that have fatty and waxy notes in the nasal cavity of mammals

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38050:Food sciences-related

  Kyoto University

  SATOSHI TSUZUKI

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  CD36;SR-B1;食品有香成分;脂肪族アルデヒド;模擬受容体ペプチド;特異的結合;GST融合タンパク質;三次元構造;食品有香物質;クラスBスカベンジャー受容体;香調ー活性相関;結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K05912/
• Elucidation of recognition mechanisms of fatty acids and their related substances by class B scavenger receptors

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  SATOSHI TSUZUKI

  From 21 Oct. 2016, To 31 Mar. 2019, Project Closed

  クラスBスカベンジャー受容体;長鎖脂肪酸;酸化型リポ蛋白質;酸化型リン脂質;CD36;脂肪族アルデヒド;嗅上皮;酸化型リポタンパク質;SR-B1;酸化型リポタンパク室;SR-BI;生体分子;食品;脂質;蛋白質;動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07733/
• Elucidation of the mechanism of matriptase activation and exploration of food components that control the activation.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Satoshi TSUZUKI

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  酵素;食品;遺伝子;バイオテクノロジー;栄養学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24580178/
• Studies on the mechanism of manifestation of fatigue and its effects on the attenuation of motivation to move and on the possibility of their control by ingestion of foods/food components

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kazuo INOUE

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  疲労;脳内自己刺激;脳報酬系;ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24380070/
• Elucidation of the role of MT-SP1 in the intestinal epithelial turnover and exploration of food components that control the activation of the molecule.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Satoshi TSUZUKI

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  腸上皮;代謝回転;基底膜;MT-SP1;活性化制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21580138/
• Integrative studies on the mechanism of central and peripheral fatigue manifestation and the development of foods that have effects of anti-fatigue and fast restoration from fatigue

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kazuo INOUE

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  疲労;脳内報酬系;エネルギー代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21380082/
• Elucidation of significance of serine proteases found in the intestines on cell death and the mechanism of the proteases-mediated cell death regulated by food components

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Satoshi TSUZUKI

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  セリンプロテアーゼ;アノイキス;アポトーシス;腸管細胞;細胞代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18580118/
• Construction of evaluation system of central fatigue and its application to developing basis of food aimed for control of human fatigue

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kazuo INOUE

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  疲労;行動学;食品;神経科学;ストレス;抗疲労;疲労回復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18380080/
• Function of cytokine in the brain in manifestation of central fatigue and its involvement to the regulation of metabolism

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuo INOUE

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  中枢性疲労;TGF-β;サイトカイン;matrix metalloproteinase;マイクロダイアリシス;in situ hybridization;リポプロテインリパーゼ;マロニルCoA, central fatigue;TGF-beta;cytokine;matrix metalloproteinase;microdialysis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16580097/
• Molecular mechanism of common disease-induced cytokine expressions in dietary fat-target cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Teruo KAWADA

  From 01 Apr. 2004, To 31 Mar. 2007, Project Closed

  生活習慣病;高脂肪食;サイトカイン;ケモカイン;マクロファージ;肥満;脂肪細胞, lifestyle related disease;high fat diet;cytokine;chemokine;macrophage;adipocyte;obesity

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16380087/
• Analysis of the mechanisms on chemical reception and producing energy signal after dietary fat intake for cause investigation of its high palatability.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tohru FUSHIKI

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  脂肪;嗜好性;口腔内刺激;カルシウムイメージング;β酸化阻害;報酬効果;CD36;エネルギー信号;FAT;口腔内受容体, dietary fat;palatability;oral stimulation;calcium imaging;inhibition of beta-oxidation;rewarding effect

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16380085/
• Studies on the role of granzyme A, a binding molecule for monitor peptide, in the CCK release mediated by the peptide

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Satoshi TSUZUKI

  From 01 Apr. 2003, To 31 Mar. 2006, Project Closed

  モニターペプチド;膵分泌性トリプシン阻害物質;コレシストキニン;グランザイムA;上皮細胞間リンパ球;腸管上皮細胞;ホルモン産生細胞;膵分泌性トリプシンインヒビター;上皮細胞間Tリンパ球;小腸上皮細胞, monitor peptide;pancreatic secretory trypsin inhibitor;cholecystokinin;granzyme A;intraepithelial lymphocytes;intestinal epithelial cells;hormone-producing cells

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15580106/
• Analysis of Molecular Mechanisms that Monitor Hypertrophy of Adipocytes

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Teruo KAWADA

  From 01 Apr. 2003, To 31 Mar. 2008, Project Closed

  脂肪細胞;シグナル伝達;脂質;生活習慣病;肥満;メタボリックシンドローム;イオンチャンネル;センサー;アディポサイトカイン;イオンチャネル, adipocyte;signal transduction;lipid;life style-related discase;obesity;metabolic syndrome

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15081205/
• Studies on the mechanisms of manifestation of central fatigue

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Kazuo INOUE

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  TGF-β;ノルアドレナリン;ドーパミン;セロトニン;マイクロダイアリシス;2瓶選択;甘味嗜好性;呼吸交換比;脳波;呼吸商, TGF-β;noradrenaline;dopamin;serotonin;microdialysis;2-bottle selection;sweet preferences;respiratory exchange ratio

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14560098/
• Mechanisms on the chemical reception of dietary fat in the oral cavity and its signaling to the brain

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Tohru FUSHIKI

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  脂質;化学受容;脂肪酸;舌リパーゼ;オルリスタット;油脂;おいしさ;味蕾細胞;エブネル腺;有郭乳頭;口腔内受容, fat;chemical reception;fatty acids;lingual lipase;orlistat

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14360075/
• Signal transduction of dietary fat and energy metabolismsthrough nucrea receptor

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Teruo KAWADA

  From 01 Apr. 2001, To 31 Mar. 2004, Project Closed

  肥満;脂質代謝;エネルギー代謝;脂肪;核内受容体;PPAR;アゴニスト;アンタゴニスト, OBESITY;LIPID METABOLISM;ENERGY METABOLISM;FAT;NUCREAR RECEPTOR;PPAR;AGONIST;ANTAGONIST

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13460058/
• モニターペプチド-受容体結合によるCCK放出機構の解明

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  都築 巧

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  膵酵素分泌;コレシストキニン;モニターペプチド;受容体;精製;プロテアーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12760087/
• CCK放出ペプチド受容体の同定とその生理的意義の解明

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  都築 巧

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  CCK;small intestine;receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09760129/
• Recognition of Fatty acids by Gastw intestinal hormone producing cells.

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Tohru FUSHIKI

  From 01 Apr. 1997, To 31 Mar. 2000, Project Closed

  消化管ホルモン;脂肪酸;消化管;ホルモン分泌;FAT;認識;CCK;膵酵素分泌;外分泌, gastrointestinal hormone;fatty acids;gastrointestinal tract;hormone nelease;FAT;recognition

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09460062/
• 長鎖脂肪酸とその細胞への取り込みを担う受容体の特異的結合相互作用の立証

  Grant-in-Aid for Scientific Research (C)

  Basic Section 59040:Nutrition science and health science-related

  Kyoto University

  都築 巧

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  長鎖脂肪酸;CD36;特異的結合相互作用;蛍光増強試験;構造解析;結合試験;結合様式

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K11825/

External funds: others

• Study on Regulatory Mechanisms of Pancreatic Enzyme Secretion by Food Components

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course of Health Science

  GA28, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Organic Chemistry

  7315, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Nutrition Chemistry Seminar

  GF04, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Nutrition Chemistry Seminar

  GF04, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course in Nutrition Chemistry

  GG04, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course in Nutrition Chemistry

  GG04, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Organic Chemistry in Food Science

  7280, Spring, Faculty of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Fundamental Biochemistry II

  7303, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Analytical Chemistry in Food Science

  7299, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Nutrition Chemistry

  7232, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course of Nuturitional Physiology I

  GA29, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Biochemistry and Microbiology

  7317, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Organic Chemistry in Food Science

  7280, Spring, Faculty of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Nutrition Chemistry Seminar2

  GB16, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Nutrition Chemistry Seminar1

  GB15, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course in Nutrition Chemistry2

  GC16, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course in Nutrition Chemistry1

  GC15, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Nutrition Chemistry

  7232, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Fundamental Biochemistry II

  7303, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Analytical Chemistry in Food Science

  7299, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course of Health Science

  GA28, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course in Nutrition Chemistry2

  GC16, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course in Nutrition Chemistry1

  GC15, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Nutrition Chemistry Seminar2

  GB16, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Nutrition Chemistry Seminar1

  GB15, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamental Biochemistry II

  7303, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Analytical Chemistry in Food Science

  7299, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Biochemistry and Microbiology

  7317, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Nutrition Chemistry

  7232, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Food Biochemistry

  7325, Spring, Faculty of Agriculture, 3
• From Apr. 2011, To Mar. 2012

  食品・栄養化学実験及び実験法

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  栄養化学専攻実験

  農学研究科
• From Apr. 2011, To Mar. 2012

  栄養化学専攻演習

  農学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory course in Nutrition Chemistry

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Biometrics

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Biometrics

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Laboratory course in Nutrition Chemistry

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Nutrition Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Course in Nutrition Chemistry

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory course in Nutrition Chemistry

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Nutrition Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course in Nutrition Chemistry

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory course in Nutrition Chemistry

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Experimental Course in Nutrition Chemistry1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course in Nutrition Chemistry

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Nutrition Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Nutrition Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory course in Nutrition Chemistry

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Experimental Course in Nutrition Chemistry1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course in Nutrition Chemistry2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course in Nutrition Chemistry

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Nutrition Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Nutrition Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Nutrition Chemistry Seminar

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Experimental Course in Nutrition Chemistry1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course in Nutrition Chemistry2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Nutrition Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Nutrition Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course in Nutrition Chemistry1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course in Nutrition Chemistry2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Nutrition Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Nutrition Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Food Biochemistry (I)

  Spring, 農学部
• From Apr. 2019, To Mar. 2020

  Nutrition Chemistry

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Experimental Course in Nutrition Chemistry1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course in Nutrition Chemistry2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Nutrition Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Nutrition Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Course of Nuturitional Physiology I

  Fall, 農学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Biochemistry and Microbiology

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2020, To Mar. 2021

  Advanced Course of Health Science

  Fall, 農学研究科
• From Apr. 2020, To Mar. 2021

  Nutrition Chemistry

  Fall, 農学部
• From Apr. 2020, To Mar. 2021

  Experimental Course in Nutrition Chemistry1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course in Nutrition Chemistry2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Nutrition Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Nutrition Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Biochemistry and Microbiology

  Spring, 農学部
• From Apr. 2020, To Mar. 2021

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Food Biochemistry

  Spring, 農学部
• From Apr. 2021, To Mar. 2022

  Fundamental Biochemistry II

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Nutrition Chemistry

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Experimental Course in Nutrition Chemistry1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course in Nutrition Chemistry2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Nutrition Chemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Nutrition Chemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Course of Nuturitional Physiology I

  Fall, 農学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Biochemistry and Microbiology

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Food Biochemistry

  Spring, 農学部

Administration

Faculty management (title, position)

• From 01 Apr. 2017, To 31 Mar. 2019

  環境・安全・衛生委員会　委員