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Uchida, Yoichiro

Graduate School of Medicine, Medicine Senior Lecturer/ Junior Associate Professor

Uchida, Yoichiro
list
    Last Updated :2022/06/24

    Basic Information

    Faculty

    • Faculty of Medicine

    Academic Degree

    • Ph.D.(Kansai Medical University)

    Academic Resume (Graduate Schools)

    • Kansai Medical University, 大学院医学研究科博士課程医科学専攻, Surgery, 修了

    Academic Resume (Undergraduate School/Majors)

    • Kansai Medical University, 医学部医学科, 卒業

    High School

    • High School

      大阪府立茨木高等学校

    Language of Instruction

    • Japanese
    • English

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2022/06/24

      Research

      Research Topics, Overview of the research

      • Research Topics

        Overcoming Ischemia and Reperfusion Injury

      • Overview of the research

        In the field of liver transplantation, ischemia and reperfusion injury (IRI) causes approximately 10% of early graft failure and leads to a higher incidence of acute and chronic rejection. It is also an urgent issue to overcome IRI from the viewpoint of organ preservation.
        In terms of the reduction of liver damages caused by IR and to offer the effective method to overcome the liver IRI for the achievement of a safer liver surgery, I have studied the efficacy of various biological molecules (neutrophil elastase inhibitor, recombinant Galectin-9, recombinant thrombomodulin/domain of thrombomodulin and so on), antioxidant agents (vitamins C and E) and maneuvers (preoperative short-term fasting).
        Among various methods I have examined, the nutritional approach in addition to anti-inflammatory drugs may play as an important role to overcome liver IRI.

      Awards

      • 09 Jul. 2009
        International Liver Transplantation Society, Rising Star Award
      • 05 Oct. 2011
        The Japan Society for Transplantation, Congress Award
      • 16 May 2012
        International Liver Transplantation Society, Young Investigator Award

      External funds: Kakenhi

      • 肝虚血再灌流障害とその制御における概日リズムの関与
        Grant-in-Aid for Scientific Research (C)
        Basic Section 55010:General surgery and pediatric surgery-related
        The Tazuke Kofukai
        寺嶋 宏明
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        肝虚血再灌流障害;絶食;概日リズム;ERAS
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08655/
      • 肝臓外科領域における食事療法の有効性および腸内環境の変動解析
        Grant-in-Aid for Scientific Research (B)
        Basic Section 55010:General surgery and pediatric surgery-related
        Kyoto University
        内田 洋一朗
        From 01 Apr. 2020, To 31 Mar. 2024, Granted
        肝虚血再灌流障害;食事制限;腸内細菌;肝臓外科;ERAS;肝移植
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03743/
      • The elucidation of mechanism of liver ischemia and reperfusion injury by diet restriction
        Grant-in-Aid for Scientific Research (C)
        Basic Section 55010:General surgery and pediatric surgery-related
        The Tazuke Kofukai
        Hiroaki Terajima
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        肝虚血再灌流障害;肝臓;絶食;食事制限;FOXO1;アセチル化ヒストン;肝臓外科;肝移植;メタボローム解析;βヒドロキシ酪酸;肝虚血再還流障害
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08609/
      • The elucidation for the role of Galectin-9 in liver ischemia and reperfusion injury
        Grant-in-Aid for Scientific Research (C)
        The Tazuke Kofukai
        Yoichiro UCHIDA
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        Galectin-9;肝虚血再灌流障害;クッパー細胞;TIM-3;Tim-3;TLR-4
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10177/
      • The elucidation for the suppressive effect of thrombomodulin in liver ischemia and reperfusion injury
        Grant-in-Aid for Scientific Research (C)
        The Tazuke Kofukai
        Hiroaki TERAJIMA
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        トロンボモジュリン;肝虚血再灌流障害;TLR-4;HMGB-1;D1分画;HMGB－１
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10041/
      • The elucidation of novel T cell function in innate immunity-dominated liver tissue damage.
        Grant-in-Aid for Challenging Exploratory Research
        The Tazuke Kofukai
        Hiroaki TERAJIMA
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        肝虚血再灌流障害;galectin-9;Tim-3;虚血再還流障害;肝臓;T細胞;TIM-3;TLR-4;マクロファージ;虚血再灌流障害;TIM;Galectin-9
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670590/
      • The Novel Role of T cell in Liver Ischemia and Reperfusion Injury
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Yoichiro UCHIDA
        From 28 Apr. 2011, To 31 Mar. 2014, Project Closed
        虚血再灌流障害;肝臓;Galectin-9;TIM;T細胞;TLR-4;肝移植;マクロファージ;自然免疫;国際情報交換;アメリカ;ガレクチン;国際情報交流
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791527/

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