Basic Information

Faculty

• Faculty of Medicine

Academic Degree

• Ph.D.(Kansai Medical University)

Academic Resume (Graduate Schools)

• Kansai Medical University, 大学院医学研究科博士課程医科学専攻, Surgery, 修了

Academic Resume (Undergraduate School/Majors)

• Kansai Medical University, 医学部医学科, 卒業

High School

• High School

  大阪府立茨木高等学校

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  202001019694770893

• Researcher number

  30597745

Website(s) (URL(s))

• https://www.kitano-hp.or.jp/kenkyu/research_activity#05

researchmap URL

• https://researchmap.jp/surgeon-uchida

Research

Research Topics, Overview of the research

• Research Topics

  Overcoming Ischemia and Reperfusion Injury

• Overview of the research

  In the field of liver transplantation, ischemia and reperfusion injury (IRI) causes approximately 10% of early graft failure and leads to a higher incidence of acute and chronic rejection. It is also an urgent issue to overcome IRI from the viewpoint of organ preservation.
  In terms of the reduction of liver damages caused by IR and to offer the effective method to overcome the liver IRI for the achievement of a safer liver surgery, I have studied the efficacy of various biological molecules (neutrophil elastase inhibitor, recombinant Galectin-9, recombinant thrombomodulin/domain of thrombomodulin and so on), antioxidant agents (vitamins C and E) and maneuvers (preoperative short-term fasting).
  Among various methods I have examined, the nutritional approach in addition to anti-inflammatory drugs may play as an important role to overcome liver IRI.

Awards

• 09 Jul. 2009

  International Liver Transplantation Society, Rising Star Award
• 05 Oct. 2011

  The Japan Society for Transplantation, Congress Award
• 16 May 2012

  International Liver Transplantation Society, Young Investigator Award

External funds: Kakenhi

• The involvement of circadian rhythm in liver ischemia-reperfusion injury

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55010:General surgery and pediatric surgery-related

  The Tazuke Kofukai

  Hiroaki Terajima

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  肝虚血再灌流障害;概日リズム;絶食;体内時計;肝臓外科;肝移植;メタボローム解析;5-アミノレブリン酸;ERAS

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08655/
• The Efficacy of dietary therapy and analysis of gut microbiota in liver surgery

  Grant-in-Aid for Scientific Research (B)

  Basic Section 55010:General surgery and pediatric surgery-related

  Kyoto University

  Yoichiro Uchida

  From 01 Apr. 2020, To 31 Mar. 2024, Project Closed

  肝虚血再灌流障害;肝臓外科;絶食;5-アミノレブリン酸;イヌリン;腸内細菌叢;短鎖脂肪酸;プロピオン酸;食事制限;腸内細菌;ERAS;肝移植

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03743/
• The elucidation of mechanism of liver ischemia and reperfusion injury by diet restriction

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55010:General surgery and pediatric surgery-related

  The Tazuke Kofukai

  Hiroaki Terajima

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  肝虚血再灌流障害;肝臓;絶食;食事制限;FOXO1;アセチル化ヒストン;肝臓外科;肝移植;メタボローム解析;βヒドロキシ酪酸;肝虚血再還流障害

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08609/
• The elucidation for the role of Galectin-9 in liver ischemia and reperfusion injury

  Grant-in-Aid for Scientific Research (C)

  The Tazuke Kofukai

  Yoichiro UCHIDA

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  Galectin-9;肝虚血再灌流障害;クッパー細胞;TIM-3;Tim-3;TLR-4

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10177/
• The elucidation for the suppressive effect of thrombomodulin in liver ischemia and reperfusion injury

  Grant-in-Aid for Scientific Research (C)

  The Tazuke Kofukai

  Hiroaki TERAJIMA

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  トロンボモジュリン;肝虚血再灌流障害;TLR-4;HMGB-1;D1分画;HMGB－１

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10041/
• The elucidation of novel T cell function in innate immunity-dominated liver tissue damage.

  Grant-in-Aid for Challenging Exploratory Research

  The Tazuke Kofukai

  Hiroaki TERAJIMA

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  肝虚血再灌流障害;galectin-9;Tim-3;虚血再還流障害;肝臓;T細胞;TIM-3;TLR-4;マクロファージ;虚血再灌流障害;TIM;Galectin-9

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670590/
• The Novel Role of T cell in Liver Ischemia and Reperfusion Injury

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yoichiro UCHIDA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  虚血再灌流障害;肝臓;Galectin-9;TIM;T細胞;TLR-4;肝移植;マクロファージ;自然免疫;国際情報交換;アメリカ;ガレクチン;国際情報交流

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791527/
• 非感染性炎症における新たな自然免疫細胞制御機構の探求

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55010:General surgery and pediatric surgery-related

  Kyoto University

  中村 公治郎

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  肝臓;虚血再灌流障害;自然免役細胞;レシピエント

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08749/
• Precise liver gene theraphy based on individual HO-1 morphism with normothermic machine perfusion

  Grant-in-Aid for Scientific Research (C)

  Basic Section 55010:General surgery and pediatric surgery-related

  Kyoto University

  影山 詔一

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  機械灌流;虚血再還流障害;machine perfusion;heme oxygenase;gene therapy;liver transplantation;normothermic

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K08047/
• マウス脂肪肝移植を用いた代謝免疫学的アプローチによる肝虚血再灌流障害の機序解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 55010:General surgery and pediatric surgery-related

  Kyoto University

  内田 洋一朗

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  脂肪肝移植;肝虚血再灌流障害;肝移植;絶食;ケトン体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02510/

Administration

Faculty management (title, position)

• From 01 Oct. 2022, To 30 Sep. 2024

  京都大学医学研究科・医学部動物実験委員会