Basic Information

Academic Degree

• 博士（医学）(京都大学)

Research History

• From Apr. 2026, To Present

  京都大学病院, 皮膚科, 助教
• From Aug. 2022, To Apr. 2026

  Icahn School of Medicine at Mount Sinai, Dermatology, Postdoctoral Fellow
• From Nov. 2019, To Jul. 2022

  京都大学病院, 皮膚科, 助教
• From Apr. 2018, To Oct. 2019

  京都大学病院, 皮膚科, 特定助教
• From Aug. 2012, To Mar. 2014

  倉敷中央病院, 皮膚科
• From Apr. 2012, To Aug. 2012

  京都大学医学部附属病院, 初期研修医
• From Apr. 2010, To Mar. 2012

  京都大学医学部附属病院, 皮膚科

ID,URL

• ORCID ID

  0000-0003-3805-2562

• J-Global ID

  201801001395608198

researchmap URL

• https://researchmap.jp/7000023113

Research

Research Topics, Overview of the research

• Research Topics

  Immunological analysis of innate immune response to the external stimuli in the skin.

Research Interests

• 神経免疫
• 迷走神経刺激
• かゆみ
• 補体系
• 刺激性皮膚炎
• 自然免疫

Papers

• An interorgan neuroimmune circuit promotes visceral hypersensitivity.

  Brian Kim; Zhen Wang; Xia Meng; Zili Xie; Chia Chun Hor; Wenwen Zhang; Xu Li; Keaton Song; Kelsey Auyeung; Hisato Iriki; Rintaro Shibuya; Wen Zhang; Jack Major; Lydia Zamidar; Daniel Yassky; Olivia Seker; Joshua Wollam; Christiane Villescaz; Alan Vest; Swetha Srinivasan; Michelle Solomon; Rui Chang; Shruti Naik; Masato Kubo; Veena Viswanath; Shawn Xu; Xinzhong Dong; David Artis; Bo Duan; Hongzhen Hu

  Research square, 17 Mar. 2025

  
• Sensory neurons promote immune homeostasis in the lung.

  Masato Tamari; Kate L Del Bel; Aaron M Ver Heul; Lydia Zamidar; Keisuke Orimo; Masato Hoshi; Anna M Trier; Hiroshi Yano; Ting-Lin Yang; Catherine M Biggs; Kenichiro Motomura; Rintaro Shibuya; Chuyue D Yu; Zili Xie; Hisato Iriki; Zhen Wang; Kelsey Auyeung; Gargi Damle; Deniz Demircioglu; Jill K Gregory; Dan Hasson; Jinye Dai; Rui B Chang; Hideaki Morita; Kenji Matsumoto; Sanjay Jain; Steven Van Dyken; Joshua D Milner; Dusan Bogunovic; Hongzhen Hu; David Artis; Stuart E Turvey; Brian S Kim

  Cell, 04 Jan. 2024

  
• Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice.

  Yoshito Yamada; Tuan Thanh Nguyen; Daniela Impellizzieri; Katsutaka Mineura; Rintaro Shibuya; Alvaro Gomariz; Martina Haberecker; Jakob Nilsson; César Nombela-Arrieta; Wolfgang Jungraithmayr; Onur Boyman

  Nature communications, 13 Mar. 2023

  
• Single-incision laparoscopic partial cecectomy for appendiceal mucocele in a patient with porphyria photosensitivity.

  Takuya Takami; Yoshiro Itatani; Rintaro Shibuya; Yoshiyuki Kiyasu; Keiko Kasahara; Daisuke Nishizaki; Ryosuke Okamura; Tomoaki Okada; Tatsuto Nishigori; Nobuaki Hoshino; Shigeo Hisamori; Shigeru Tsunoda; Koya Hida; Kenji Kawada; Kazutaka Obama

  Asian journal of endoscopic surgery, Jan. 2023

  
• Skin-homing basophils and beyond.

  Rintaro Shibuya; Brian S Kim

  Frontiers in immunology, 2022

  
• Decidualization of Stromal Cells Promotes Involvement of Mast Cells in Successful Human Pregnancy by Increasing Stem Cell Factor Expression.

  Chiyuki Ueshima; Tatsuki R Kataoka; Mitsumasa Osakabe; Akihiko Sugimoto; Akihiko Ushirokawa; Yuji Shibata; Hiroya Nakamura; Rintaro Shibuya; Sachiko Minamiguchi; Tamotsu Sugai; Hironori Haga

  Frontiers in immunology, 2022

  
• Alopecia areata in a patient with cytotoxic T lymphocyte antigen-4 haploinsufficiency successfully treated with topical delgocitinib ointment.

  Akiyoshi Senda; Rintaro Shibuya; Toshiya Miyake; Takashi Nomura; Teruki Dainichi; Kenji Kabashima

  Journal of the European Academy of Dermatology and Venereology : JEADV, 18 Aug. 2023

  
• Infiltration and local differentiation of bone marrow-derived integrinβ7-positive mast cell progenitors in atopic dermatitis-like skin.

  Yuki Honda Keith; Tetsuya Honda; Sachiko Ono; Bernett Lee; Rintaro Shibuya; Sho Hanakawa; Yoshihiro Ishida; Satoshi Nakamizo; Kenji Kabashima

  The Journal of allergy and clinical immunology, 17 Sep. 2022

  
• A New Era with the Development of Cytokine-Based Therapy for Pruritus.

  Rintaro Shibuya; Riko Takimoto-Ito; Naotomo Kambe; Kenji Kabashima

  The Journal of investigative dermatology, Jan. 2022

  
• Anti-BP180, pruritus, and thymus and activation-regulated chemokines as surrogate markers for disease activity in bullous pemphigoid.

  S Wada; T Komori; C S de Jesus; T Nomura; T Komura; S Yonekura; R Shibuya; E Adachi; Y Sakurai; M Ishikawa; S Usui; N Kambe; K Kabashima

  Journal of the European Academy of Dermatology and Venereology : JEADV, 20 Jul. 2022

  
• Circadian rhythm affects the magnitude of contact hypersensitivity response in mice.

  Toshiya Miyake; Gyohei Egawa; Zachary Chow; Ryota Asahina; Masayuki Otsuka; Saeko Nakajima; Takashi Nomura; Rintaro Shibuya; Yoshihiro Ishida; Satoshi Nakamizo; Teruasa Murata; Akihiko Kitoh; Kenji Kabashima

  Allergy, 15 Apr. 2022

  
• CCL2‒CCR2 Signaling in the Skin Drives Surfactant-Induced Irritant Contact Dermatitis through IL-1β‒Mediated Neutrophil Accumulation

  Rintaro Shibuya; Yoshihiro Ishida; Sho Hanakawa; Tatsuki R. Kataoka; Yasuhide Takeuchi; Teruasa Murata; Arisa Akagi; Zachary Chow; Toshiaki Kogame; Satoshi Nakamizo; Saeko Nakajima; Gyohei Egawa; Takashi Nomura; Naotomo Kambe; Akihiko Kitoh; Kenji Kabashima

  Journal of Investigative Dermatology, 2021

  
• Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis.

  Satoshi Nakamizo; Charles-Antoine Dutertre; Ahad Khalilnezhad; Xiao Meng Zhang; Shawn Lim; Josephine Lum; Geraldine Koh; Charlene Foong; Pearly Jean Ai Yong; Kahbing Jasmine Tan; Reiko Sato; Kaori Tomari; Laurent Yvan-Charvet; Helen He; Emma Guttman-Yassky; Benoit Malleret; Rintaro Shibuya; Masashi Iwata; Baptiste Janela; Tsuyoshi Goto; Tan Siyun Lucinda; Mark B Y Tang; Colin Theng; Valerie Julia; Feriel Hacini-Rachinel; Kenji Kabashima; Florent Ginhoux

  The Journal of experimental medicine, 06 Sep. 2021

  
• Percutaneous sensitization is limited by in situ inhibition of cutaneous dendritic cell migration through skin-resident regulatory T cells

  Sho Hanakawa; Akihiko Kitoh; Rintaro Shibuya; Teruki Dainichi; Takashi Nomura; Tetsuya Honda; Gyohei Egawa; Atsushi Otsuka; Saeko Nakajima; Mitsugu Fujita; Kenji Kabashima

  Journal of Allergy and Clinical Immunology, Nov. 2019, Peer-reviewed

  
• Dual CD4/CD8-positive Ichthyosiform Mycosis Fungoides with Lymph Node, Peripheral Blood and Cardiac Involvement: A Case Report

  Yo Kaku; Atsushi Otsuka; Hideaki Tanizaki; Rintaro Shibuya; Yuichiro Endo; Yumi Nonomura; Masahiro Hirata; Masakazu Fujimoto; Katsuyuki Ohmori; Takaki Sakurai; Kenji Kabashima

  ACTA DERMATO-VENEREOLOGICA, 2016, Peer-reviewed

  Access this paper :

  
• A plaque-type solitary reticulohistiocytoma in a two-year-old boy

  Rintaro Shibuya; Hideaki Tanizaki; Yo Kaku; Masao Yonezawa; Yuri Ryu; Atsushi Otsuka; Kenji Kabashima; Yoshiki Miyachi

  Case Reports in Dermatology, 22 May 2015, Peer-reviewed

  
• DIHS/DRESS with Remarkable Eosinophilic Pneumonia Caused by Zonisamide

  Rintaro Shibuya; Hideaki Tanizaki; Saeko Nakajima; Itsuko Koyanagi; Tatsuki R. Kataoka; Yoshiki Miyachi; Kenji Kabashima

  ACTA DERMATO-VENEREOLOGICA, 2015, Peer-reviewed

  Access this paper :

  
• Granuloma caused by carbon deposition in the dermis.

  Rintaro Shibuya; Yuichiro Endo; Akihiro Fujisawa; Miki Tanioka; Yoshiki Miyachi

  Case reports in dermatological medicine, 2014, Peer-reviewed

  
• Cutaneous miliary tuberculosis in a patient with long-term steroid treatment for microscopic polyangiitis.

  Rintaro Shibuya; Yuichiro Endo; Akihiro Fujisawa; Miki Tanioka; Yutaka Ito; Yoshiki Miyachi

  European journal of dermatology : EJD, 01 Apr. 2013, Peer-reviewed

  
• Oral allergy syndrome complicated with multiple food sensitization detected by specific IgEs

  Rintaro Shibuya; Hideaki Tanizaki; Gyohei Egawa; Hiromi Doi; Akihiro Fujisawa; Miki Tanioka; Kenji Kabashima; Yoshiki Miyachi

  EUROPEAN JOURNAL OF DERMATOLOGY, Jul. 2012, Peer-reviewed

  

Misc.

• The role of C5a-C5aR1 axis in keratinocyte activation

  R. Shibuya; A. Kitoh; K. Kabashima

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Oct. 2017

  
• The C5a-C5aR1 axis suppresses the Aldara-induced immune activation

  R. Shibuya; A. Kitoh; K. Kabashima

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2017

  
• Natural IgE production intrinsically requires CD1d expression on B cells

  A. Kitoh; R. Shibuya; K. Kabashima

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016

  
• ハチ刺症による横紋筋融解症の1例

  原本理恵; 渋谷倫太郎; 井形華絵; 大谷稔男

  臨床皮膚科, 01 Feb. 2015

  
• ランサップ800に含まれるアモキシシリンとランソプラゾールによる薬疹の1例

  渋谷倫太郎; 原本理恵; 井形華絵; 大谷稔男

  臨床皮膚科, 01 Jan. 2015

  
• 血管炎・血行障害・紫斑病 紫斑を契機に診断したIgA‐λ型多発性骨髄腫の1例

  渋谷倫太郎; 大谷稔男; 岡田和也; 島田典明

  皮膚科の臨床, 01 May 2014

  
• 皮下脂肪織炎の像を呈した続発性皮膚形質細胞腫の1例

  原本理恵; 渋谷倫太郎; 井形華絵; 大谷稔男; 松井宏行

  日本皮膚科学会雑誌, 15 Apr. 2014

  
• 肺病変を合併した壊疽性膿皮症にTNF‐α阻害薬が奏効した1例

  小川万里依; 遠藤雄一郎; 藤澤章弘; 谷岡未樹; 椛島健治; 宮地良樹; 渋谷真美; 渋谷倫太郎; 白方裕司

  皮膚の科学, Apr. 2014

  
• Annular Elastolytic Giant Cell Granuloma

  渋谷倫太郎; 大谷稔男; 多田廣祠

  倉敷中央病院年報, 31 Mar. 2014

  
• Two Cases of Cutaneous Metastasis from the Lungs

  原本理恵; 渋谷倫太郎; 井形華絵; 大谷稔男

  倉敷中央病院年報, 31 Mar. 2014

  
• 蜂刺症による横紋筋融解症の1例

  原本理恵; 渋谷倫太郎; 井形華絵; 大谷稔男

  日本皮膚科学会雑誌, 20 Mar. 2014

  
• ランサップ800によるH.pylori除菌療法後に生じた薬疹の1例

  渋谷倫太郎; 原本理恵; 井形華絵; 大谷稔男

  皮膚の科学, Feb. 2014

  
• 肺癌皮膚転移の2例

  原本理恵; 渋谷倫太郎; 井形華絵; 大谷稔男

  日本皮膚科学会雑誌, 20 Nov. 2013

  
• 13年の経過で2ヶ所に個別に生じた悪性黒色腫の1例

  渋谷 倫太郎; 遠藤 雄一郎; 藤澤 章弘; 谷岡 未樹; 椛島 健治; 宮地 良樹

  臨床皮膚科, 01 Oct. 2013

  
• 白血球除去療法が奏効した壊疽性膿皮症の1例

  渋谷倫太郎; 遠藤雄一郎; 藤澤章弘; 谷岡未樹; 椛島健治; 宮地良樹; 白方裕司

  日本皮膚科学会雑誌, 20 Apr. 2013

  
• ステロイド外用が奏効した汎発型環状肉芽腫の1例

  渋谷倫太郎; 野村尚史; 遠藤雄一郎; 藤澤章弘; 谷岡未樹; 椛島健治; 宮地良樹

  皮膚の科学, Aug. 2012

  
• 乳房温存術後に出現した血管肉腫の2例

  伊賀那津子; 渋谷倫太郎; 登谷晶美; 遠藤雄一郎; 藤澤章弘; 谷岡未樹; 椛島健治; 宮地良樹

  皮膚の科学, Aug. 2012

  
• 13年の経過で2ケ所に個別に生じた悪性黒色腫の1例

  渋谷倫太郎; 志熊恵美; 遠藤雄一郎; 藤澤章弘; 谷岡未樹; 椛島健治; 宮地良樹

  皮膚の科学, Apr. 2012

  
• 肝移植ドナー検診で見つかった家族性Brugada症候群の兄弟例

  渋谷倫太郎; 早野護; 八幡光彦; 牧山武; 土井孝浩; 静田聡; 尾野亘; 塩井哲雄; 木村剛

  日本循環器学会近畿地方会(Web), 2010

  

Presentations

• Essential Roles of CCL2-CCR2 and C5a-C5aR1 Pathways in irritant Contact Dermatitis

  Rintaro Shibuya

  The NIF Winter School 2019, Jan. 2019

  
• Promotion of imiquimod-induced keratinocyte activation via C5a-C5aR1 axis

  渋谷 倫太郎

  日本研究皮膚科学会, Dec. 2017

  

External funds: Kakenhi

• 皮膚自然免疫における間葉系細胞のCCL2-CCR2経路を介した制御機構解析

  Grant-in-Aid for Early-Career Scientists

  Basic Section 53050:Dermatology-related

  Kyoto University

  渋谷 倫太郎

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  刺激性皮膚炎;CCL2;CCR2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17317/
• The role of complement system in the cutaneous immune response toward external stimuli

  Grant-in-Aid for Research Activity Start-up

  0903:Organ-based internal medicine and related fields

  Kyoto University

  Rintaro Shibuya

  From 24 Aug. 2018, To 31 Mar. 2020, Project Closed

  刺激性皮膚炎;補体;好塩基球;C5a;上皮傷害;皮膚免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K21326/