Basic Information

Academic Degree

• (Kyoto University)
• (Kyoto University)

Academic Resume (Graduate Schools)

• Kyoto University, Graduate School of Biostudies, 修了
• Kyoto University, Graduate School of Biostudies, 修了

Academic Resume (Undergraduate School/Majors)

• Kyoto University, Faculty of Agriculture, 卒業

Research History

• From May 2023, To Present

  Kyoto University, Graduate School of Biostudies, Associate Professor
• From Oct. 2015, To Apr. 2023

  Kyoto University, Graduate School of Biostudies, 助教
• From Oct. 2013, To Sep. 2015

  Ishikawa Prefectural University, 生物資源工学研究所, 助教
• From Nov. 2007, To Sep. 2013

  University of Georgia, Complex Carbohydrate Reseach Center, 博士研究員

ID,URL

• ORCID ID

  0000-0002-7996-5619

• J-Global ID

  201601018340670671

Website(s) (URL(s))

• https://intestinal-glycan-dialogue.jp/
• https://www.bunshioutou.lif.kyoto-u.ac.jp/Home.html

researchmap URL

• https://researchmap.jp/7000015969

Research

Research Topics, Overview of the research

• Research Topics

  Study of degradation/assimilation pathway of glycoconjugates by gut microbes and other bacteria. Study for glycan synthesis using glycan-related enzymes.

• Overview of the research

  By elucidating the molecular mechanisms by which glycoside hydrolases (GHs) from gut microbiota—particularly Bifidobacteria—degrade the glycans present in intestinal mucus mucins, we aim to deepen our understanding of the symbiotic relationship between gut microbes and the human host.

Research Interests

• Bifidobacterium
• グライコミクス
• グリコシダーゼ
• 腸内細菌
• 糖鎖生物学
• 応用微生物学

Research Areas

• Life sciences, Functional biochemistry, Glycan, carbohydrate-active enzyme, glycan-binding protein
• Life sciences, Applied microbiology, Bifidobacterium, gut microbes, carbohydrate-active enzyme

Papers

• Unique bifunctional α-sialidase/β-N-acetylgalactosaminidase from Bifidobacterium bifidum acting on the Sda antigen

  Toshihiko Katoh; Rina Suzuki; Shogo Kataoka; Junya Kawasaki; Keijiro Kamio; Masahiro Komeno; Saya Yoshioka; Annemette Tengstedt Rasmussen; Ikuo Kimura; Takane Katayama; Hisashi Ashida

  Journal of Biological Chemistry, Feb. 2026

  
• Human milk oligosaccharides and infant gut microbiome in Mongolian mother-infant dyads

  Enkhtuul Davaanyam; Undarmaa Otgonbaatar; Aruto Nakajima; Mikiyasu Sakanaka; Miriam N. Ojima; Tomoya Kozakai; Toshihiko Katoh; Toshitaka Odamaki; Batkhuu Javzan; Enkhmaa Dagvadorj; Davaapurev Bekh-Ochir; Takane Katayama

  Journal of Dairy Science, Nov. 2025

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• Suppression of fecal phenol production by oral supplementation of sesamol: inhibition of tyrosine phenol-lyase by sesamol

  Daiki Oikawa; Zion Byun; Bunzo Mikami; Aina Gotoh; Toshihiko Katoh; Ryo Ueno; Aruto Nakajima; Satoshi Yamashita; Wakako Ikeda-Ohtsubo; Seiji Takahashi; Toshiyuki Waki; Koichi Kikuchi; Takaaki Abe; Takane Katayama; Toru Nakayama

  Food & Function, 2025

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• In vitro competition with Bifidobacterium strains impairs potentially pathogenic growth of Clostridium perfringens on 2′-fucosyllactose

  Aruto Nakajima; Aleksandr A. Arzamasov; Mikiyasu Sakanaka; Ryuta Murakami; Tomoya Kozakai; Keisuke Yoshida; Toshihiko Katoh; Miriam N. Ojima; Junko Hirose; Saeko Nagao; Jin-Zhong Xiao; Toshitaka Odamaki; Dmitry A. Rodionov; Takane Katayama

  Gut Microbes, 18 Mar. 2025

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• A thermostable and highly active fungal GH3 β-glucosidase generated by random and saturation mutagenesis

  Chiaki MATSUZAKI; Masafumi HIDAKA; Yukari NAKASHIMA; Yuji HONDA; Takashi KOYANAGI; Kazuhiko ISHIKAWA; Toshihiko KATOH; Takane KATAYAMA; Hidehiko KUMAGAI

  Proceedings of the Japan Academy, Series B, 2025

  
• 乳児腸管におけるビフィズスフローラ形成には母乳オリゴ糖分解物のクロスフィーディングが関与する？

  紀彦 加藤; 愛那 後藤; 望美 尾島; 高嶺 片山

  ミルクサイエンス, 2019

  
• Glycoenzymes in Glycan Analysis and Synthesis

  Toshihiko Katoh; Kenji Yamamoto

  Glycoscience: Biology and Medicine, 2015

  
• Degradation of Glycoproteins

  H. Ashida; T. Kato; K. Yamamoto

  Comprehensive Glycoscience, 2007

  
• An improved temperature-sensitive shuttle vector system for scarless gene deletion in human gut-associated Bifidobacterium species

  Tomoya Kozakai; Aruto Nakajima; Keisuke Miyazawa; Yuki Sasaki; Toshitaka Odamaki; Toshihiko Katoh; Takeshi Fukuma; Jin-zhong Xiao; Tohru Suzuki; Takane Katayama; Mikiyasu Sakanaka

  iScience, Oct. 2024

  
• Cultivation of Microorganisms in Media Supplemented with Mucin Glycoproteins.

  Hiromi Takada; Takane Katayama; Toshihiko Katoh

  Methods in molecular biology (Clifton, N.J.), 2024

  
• Bacterial Enzyme Assay for Mucin Glycan Degradation.

  Toshihiko Katoh; Hisashi Ashida

  Methods in molecular biology (Clifton, N.J.), 2024

  
• Human gut-associated Bifidobacterium species salvage exogenous indole, a uremic toxin precursor, to synthesize indole-3-lactic acid via tryptophan.

  Cheng Chung Yong; Takuma Sakurai; Hiroki Kaneko; Ayako Horigome; Eri Mitsuyama; Aruto Nakajima; Toshihiko Katoh; Mikiyasu Sakanaka; Takaaki Abe; Jin-Zhong Xiao; Miyuki Tanaka; Toshitaka Odamaki; Takane Katayama

  Gut microbes, 2024

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• The N's and O's of Drosophila glycoprotein glycobiology.

  Toshihiko Katoh; Michael Tiemeyer

  Glycoconjugate journal, Jan. 2013

  
• ZNT5-6 and ZNT7 play an integral role in protein N-glycosylation by supplying Zn2+ to Golgi α-mannosidase II

  Hana Yuasa; Naho Morino; Takumi Wagatsuma; Masayuki Munekane; Sachiko Ueda; Mayu Matsunaga; Yasuo Uchida; Takane Katayama; Toshihiko Katoh; Taiho Kambe

  Journal of Biological Chemistry, Jun. 2024

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• Mucin Decomposition Mechanisms in Gut Bacteria

  Toshihiko Katoh; Takane Katayama

  Glycoforum, Feb. 2024, Invited, Lead author

  
• Identification of Core Yeast Species and Microbe-Microbe Interactions Impacting Larval Growth ofDrosophilain the Wild

  Ayumi Mure; Yuki Sugiura; Rae Maeda; Kohei Honda; Nozomu Sakurai; Yuuki Takahashi; Masayoshi Watada; Toshihiko Katoh; Aina Gotoh; Yasuhiro Gotoh; Itsuki Taniguchi; Keiji Nakamura; Tetsuya Hayashi; Takane Katayama; Tadashi Uemura; Yukako Hattori

  eLife, 03 Aug. 2023

  
• GH20 and GH84 β-N-acetylglucosaminidases with different linkage specificities underpin mucin O-glycan breakdown capability of Bifidobacterium bifidum

  Hiromi Takada; Toshihiko Katoh; Mikiyasu Sakanaka; Toshitaka Odamaki; Takane Katayama

  Journal of Biological Chemistry, May 2023, Peer-reviewed

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• Comprehensive analysis of metabolites produced by co-cultivation of Bifidobacterium breve MCC1274 with human iPS-derived intestinal epithelial cells

  Akira Sen; Tatsuki Nishimura; Shin Yoshimoto; Keisuke Yoshida; Aina Gotoh; Toshihiko Katoh; Yasuko Yoneda; Toyoyuki Hashimoto; Jin-Zhong Xiao; Takane Katayama; Toshitaka Odamaki

  Frontiers in Microbiology, 13 Apr. 2023, Peer-reviewed

  
• A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem.

  Toshihiko Katoh; Chihaya Yamada; Michael D Wallace; Ayako Yoshida; Aina Gotoh; Moe Arai; Takako Maeshibu; Toma Kashima; Arno Hagenbeek; Miriam N Ojima; Hiromi Takada; Mikiyasu Sakanaka; Hidenori Shimizu; Keita Nishiyama; Hisashi Ashida; Junko Hirose; Maria Suarez-Diez; Makoto Nishiyama; Ikuo Kimura; Keith A Stubbs; Shinya Fushinobu; Takane Katayama

  Nature chemical biology, 02 Mar. 2023

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• A fluorogenic probe for core-fucosylated glycan-preferred ENGase.

  Nozomi Ishii; Hiroshi Muto; Mitsuo Nagata; Kanae Sano; Itsuki Sato; Kenta Iino; Yuji Matsuzaki; Toshihiko Katoh; Kenji Yamamoto; Ichiro Matsuo

  Carbohydrate research, Jan. 2023

  
• Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides.

  MN OJIMA; Lin Jiang; Aleksandr Arzamasov; Keisuke Yoshida; Toshitaka Odamaki; Jinzhong Xiao; Aruto Nakajima; Motomitsu Kitaoka; Hirose J; Urashima T; Katoh T; Gotoh A; Douwe van Sinderen; Rodionov DA; Osterman AL; Sakanaka M; Takane Katayama

  The ISME journal, 29 Jun. 2022

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• A simple method that enhances minority species detection in the microbiota: 16S metagenome-DRIP (Deeper Resolution using an Inhibitory Primer)

  Aruto Nakajima; Keisuke Yoshida; Aina Gotoh; Toshihiko Katoh; Miriam N. Ojima; Mikiyasu Sakanaka; Jin-Zhong Xiao; Toshitaka Odamaki; Takane Katayama

  Microbiome Research Reports, 2022

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• Diversification of a Fucosyllactose Transporter within the Genus Bifidobacterium.

  Miriam N Ojima; Yuya Asao; Aruto Nakajima; Toshihiko Katoh; Motomitsu Kitaoka; Aina Gotoh; Junko Hirose; Tadasu Urashima; Satoru Fukiya; Atsushi Yokota; Maher Abou Hachem; Mikiyasu Sakanaka; Takane Katayama

  Applied and environmental microbiology, 25 Jan. 2022

  
• Innovative Preparation of Biopharmaceuticals Using Transglycosylation Activity of Microbial Endoglycosidases

  Toshihiko Katoh; Kenji Yamamoto

  Journal of Applied Glycoscience, 11 Mar. 2021

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• Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways

  Michael Jakob Pichler; Chihaya Yamada; Bashar Shuoker; Camila Alvarez-Silva; Aina Gotoh; Maria Louise Leth; Erwin Schoof; Toshihiko Katoh; Mikiyasu Sakanaka; Takane Katayama; Chunsheng Jin; Niclas G. Karlsson; Manimozhiyan Arumugam; Shinya Fushinobu; Maher Abou Hachem

  Nature Communications, Dec. 2020, Peer-reviewed

  
• Bifidobacterium bifidum Suppresses Gut Inflammation Caused by Repeated Antibiotic Disturbance Without Recovering Gut Microbiome Diversity in Mice

  Miriam N. Ojima; Aina Gotoh; Hiromi Takada; Toshitaka Odamaki; Jin-Zhong Xiao; Toshihiko Katoh; Takane Katayama

  Frontiers in Microbiology, 18 Jun. 2020, Peer-reviewed

  
• Sialylated O-Glycans from Hen Egg White Ovomucin are Decomposed by Mucin-degrading Gut Microbes.

  Takada H; Toshihiko Katoh; Katayama T

  Journal of applied glycoscience, 20 May 2020

  
• Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules.

  Katoh T; MN OJIMA; Mikiyasu Sakanaka; Hisashi Ashida; Gotoh A; Takane Katayama

  Microorganisms, 28 Mar. 2020, Peer-reviewed

  
• Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis.

  Mikiyasu Sakanaka; Morten Ejby Hansen; Aina Gotoh; Toshihiko Katoh; Keisuke Yoshida; Toshitaka Odamaki; Hiroyuki Yachi; Yuta Sugiyama; Shin Kurihara; Junko Hirose; Tadasu Urashima; Jin-Zhong Xiao; Motomitsu Kitaoka; Satoru Fukiya; Atsushi Yokota; Leila Lo Leggio; Maher Abou Hachem; Takane Katayama

  Science advances, Aug. 2019, Peer-reviewed

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• Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum.

  Aina Gotoh; Toshihiko Katoh; Mikiyasu Sakanaka; Yiwei Ling; Chihaya Yamada; Sadaki Asakuma; Tadasu Urashima; Yusuke Tomabechi; Ayako Katayama-Ikegami; Shin Kurihara; Kenji Yamamoto; Gaku Harata; Fang He; Junko Hirose; Motomitsu Kitaoka; Shujiro Okuda; Takane Katayama

  Scientific reports, 18 Sep. 2018, Peer-reviewed

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• Chemo-enzymatic synthesis of the glucagon containing N-linked oligosaccharide and its characterization

  Takayuki Higashiyama; Midori Umekawa; Masaya Nagao; Toshihiko Katoh; Hisashi Ashida; Kenji Yamamoto

  Carbohydrate Research, 02 Jan. 2018, Peer-reviewed

  
• Glycosylation engineering of therapeutic IgG antibodies: challenges for the safety, functionality and efficacy

  Yusuke Mimura; Toshihiko Katoh; Radka Saldova; Roisin O’Flaherty; Tomonori Izumi; Yuka Mimura-Kimura; Toshiaki Utsunomiya; Yoichi Mizukami; Kenji Yamamoto; Tsuneo Matsumoto; Pauline M. Rudd

  Protein and Cell, 01 Jan. 2018, Peer-reviewed

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• Bifunctional properties and characterization of a novel sialidase with esterase activity from Bifidobacterium bifidum.

  Hisashi Ashida; Tanigawa K; Kiyohara M; Katoh T; Takane Katayama; Yamamoto K

  Bioscience, biotechnology, and biochemistry, 20 Jul. 2018, Peer-reviewed

  
• Structural characterization of the immunostimulatory exopolysaccharide produced by Leuconostoc mesenteroides strain NTM048

  Chiaki Matsuzaki; Chikahiro Takagaki; Yusuke Tomabechi; Lennart S. Forsberg; Christian Heiss; Parastoo Azadi; Kenji Matsumoto; Toshihiko Katoh; Koji Hosomi; Jun Kunisawa; Kenji Yamamoto; Keiko Hisa

  CARBOHYDRATE RESEARCH, Aug. 2017, Peer-reviewed

  
• Application study of 1,2-alpha-L-fucosynthase: introduction of Fuc alpha 1-2Gal disaccharide structures on N-glycan, ganglioside, and xyloglucan oligosaccharide

  Yuta Sugiyama; Toshihiko Katoh; Yuji Honda; Aina Gotoh; Hisashi Ashida; Shin Kurihara; Kenji Yamamoto; Takane Katayama

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Feb. 2017, Peer-reviewed

  
• Identification and characterization of a sulfoglycosidase from Bifidobacterium bifidum implicated in mucin glycan utilization

  Toshihiko Katoh; Takako Maeshibu; Kei-ichi Kikkawa; Aina Gotoh; Yusuke Tomabechi; Motoharu Nakamura; Wei-Hsiang Liao; Masanori Yamaguchi; Hisashi Ashida; Kenji Yamamoto; Takane Katayama

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, Peer-reviewed

  
• Use of Gifu Anaerobic Medium for culturing 32 dominant species of human gut microbes and its evaluation based on short-chain fatty acids fermentation profiles

  Aina Gotoh; Misaki Nara; Yuta Sugiyama; Mikiyasu Sakanaka; Hiroyuki Yachi; Aya Kitakata; Akira Nakagawa; Hiromichi Minami; Shujiro Okuda; Toshihiko Katoh; Takane Katayama; Shin Kurihara

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, Peer-reviewed

  
• Chemo-enzymatic synthesis of a glycosylated peptide containing a complex N-glycan based on unprotected oligosaccharides by using DMT-MM and Endo-M

  Tomabechi, Yusuke; Katoh, Toshihiko; Kunishima, Munetaka; Inazu, Toshiyuki; Yamamoto, Kenji

  Glycoconjugate Journal, 2017, Peer-reviewed

  
• Transglycosidase-like activity of Mucor hiemalis endoglycosidase mutants enabling the synthesis of glycoconjugates using a natural glycan donor

  Kouta Sakaguchi; Toshihiko Katoh; Kenji Yamamoto

  BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, Nov. 2016, Peer-reviewed

  
• Introduction of H-antigens into oligosaccharides and sugar chains of glycoproteins using highly efficient 1,2-alpha-L-fucosynthase

  Yuta Sugiyama; Aina Gotoh; Toshihiko Katoh; Yuji Honda; Erina Yoshida; Shin Kurihara; Hisashi Ashida; Hidehiko Kumagai; Kenji Yamamoto; Motomitsu Kitaoka; Takane Katayama

  GLYCOBIOLOGY, Nov. 2016, Peer-reviewed

  
• Generation of a Mutant Mucor hiemalis Endoglycosidase That Acts on Core-fucosylated N-Glycans

  Toshihiko Katoh; Takane Katayama; Yusuke Tomabechi; Yoshihide Nishikawa; Jyunichi Kumada; Yuji Matsuzaki; Kenji Yamamoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2016, Peer-reviewed

  
• Levansucrase from Leuconostoc mesenteroides NTM048 produces a levan exopolysaccharide with immunomodulating activity

  Ryuichi Ishida; Kouta Sakaguchi; Chiaki Matsuzaki; Toshihiko Katoh; Nobuaki Ishida; Kenji Yamamoto; Keiko Hisa

  BIOTECHNOLOGY LETTERS, Apr. 2016, Peer-reviewed

  
• Comparison of the activity to stimulate mucosal IgA production between Leuconostoc mesenteroides strain NTM048 and type strain JCM6124 in mice

  Chiaki Matsuzaki; Kenji Matsumoto; Toshihiko Katoh; Kenji Yamamoto; Keiko Hisa

  Bioscience of Microbiota, Food and Health, 2016, Peer-reviewed

  
• Exopolysaccharides Produced by Leuconostoc mesenteroides Strain NTM048 as an Immunostimulant To Enhance the Mucosal Barrier and Influence the Systemic Immune Response

  Chiaki Matsuzaki; Asuka Hayakawa; Kenji Matsumoto; Toshihiko Katoh; Kenji Yamamoto; Keiko Hisa

  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, Aug. 2015, Peer-reviewed

  
• Novel substrate specificities of two lacto-N-biosidases towards beta-linked galacto-N-biose-containing oligosaccharides of globo H, Gb5, and GA1

  Aina Gotoh; Toshihiko Katoh; Yuta Sugiyama; Shin Kurihara; Yuji Honda; Haruko Sakurama; Taiho Kambe; Hisashi Ashida; Motomitsu Kitaoka; Kenji Yamamoto; Takane Katayama

  CARBOHYDRATE RESEARCH, May 2015, Peer-reviewed

  
• Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

  Takumi Kiwamoto; Toshihiko Katoh; Christopher M. Evans; William J. Janssen; Mary E. Brummet; Sherry A. Hudson; Zhou Zhu; Michael Tiemeyer; Bruce S. Bochner

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, May 2015, Peer-reviewed

  
• Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis.

  Kiwamoto,Takumi; Toshihiko,Katoh; Christopher,M. Evans; William,J. Janssen; Mary,E. Brummet; Sherry,A. Hudson; Zhou,Zhu; Michael,Tiemeyer; Bruce,S. Bochner

  アレルギー, Apr. 2015

  
• Neurons and Glia Modify Receptor Protein-tyrosine Phosphatase zeta (RPTP zeta)/Phosphacan with Cell-specific O-Mannosyl Glycans in the Developing Brain

  Chrissa A. Dwyer; Toshihiko Katoh; Michael Tiemeyer; Russell T. Matthews

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2015, Peer-reviewed

  
• Improved In-gel Reductive beta-Elimination for Comprehensive O-linked and Sulfo-glycomics by Mass Spectrometry

  David B. Nix; Tadahiro Kumagai; Toshihiko Katoh; Michael Tiemeyer; Kazuhiro Aoki

  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, Nov. 2014, Peer-reviewed

  
• Deficiency of alpha-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans

  Toshihiko Katoh; Juri Takase; Yasushi Tani; Ryuta Amamoto; Naofumi Aoshima; Michael Tiemeyer; Kenji Yamamoto; Hisashi Ashida

  GLYCOBIOLOGY, Oct. 2013, Peer-reviewed

  
• Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65

  Yi Xiang; Xiaoyan Zhang; David B. Nix; Toshihiko Katoh; Kazuhiro Aoki; Michael Tiemeyer; Yanzhuang Wang

  NATURE COMMUNICATIONS, Apr. 2013, Peer-reviewed

  
• The role of lung epithelial ligands for Siglec-8 and Siglec-F in eosinophilic inflammation.

  Takumi Kiwamoto; Katoh T; Tiemeyer M; Bochner BS

  Current opinion in allergy and clinical immunology, 01 Feb. 2013, Peer-reviewed

  
• In-gel β-elimination and aqueous-organic partition for improved O- and sulfoglycomics.

  Kumagai T; Katoh T; Nix DB; Tiemeyer M; Kazuhiro Aoki

  Analytical chemistry, 27 Aug. 2013, Peer-reviewed

  
• Neural-specific alpha 3-fucosylation of N-linked glycans in the Drosophila embryo requires Fucosyltransferase A and influences developmental signaling associated with O-glycosylation

  Dubravko Rendic; Mary Sharrow; Toshihiko Katoh; Bryan Overcarsh; Khoi Nguyen; Joseph Kapurch; Kazuhiro Aoki; Iain B. H. Wilson; Michael Tiemeyer

  GLYCOBIOLOGY, Nov. 2010, Peer-reviewed

  
• Glucosamine induces autophagy via an mTOR-independent pathway

  Tomoya Shintani; Fumiyoshi Yamazaki; Toshihiko Katoh; Midori Umekawa; Yoshiharu Matahira; Seiji Hori; Akira Kakizuka; Kazuhide Totani; Kenji Yamamoto; Hisashi Ashida

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2010, Peer-reviewed

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• Enzymes Involved in Generation and Degradation of the Free Oligosaccharides in the Cytosol of Caenorhabditis elegans

  Hisashi Ashida; Toshihiko Kato; Akihito Kawahara; Yuki Tanaka; Midori Umekawa; Kenji Yamamoto

  Journal of Applied Glycoscience, 2009

  
• Unique peptide : N-glycanase of Caenorhabditis elegans has activity of protein disulphide reductase as well as of deglycosylation

  Toshihiko Kato; Akihito Kawahara; Hisashi Ashida; Kenji Yamamoto

  JOURNAL OF BIOCHEMISTRY, Aug. 2007, Peer-reviewed

  
• Free oligosaccharides in the cytosol of Caenorhabditis elegans are generated through endoplasmic reticulum-Golgi trafficking

  Toshihiko Kato; Kumiko Kitamura; Megumi Maeda; Yoshinobu Kimura; Takane Katayama; Hisashi Ashida; Kenji Yamamoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2007, Peer-reviewed

  
• Identification of an endo-beta-N-acetylglucosaminidase gene in Caenorhabditis elegans and its expression in Escherichia coli

  T Kato; K Fujita; M Takeuchi; K Kobayashi; S Natsuka; K Ikura; H Kumagai; Y Yamamoto

  GLYCOBIOLOGY, Oct. 2002, Peer-reviewed

  

Misc.

• 個体成長を支えるショウジョウバエ共生酵母・共生細菌の栄養基盤の解析

  牟禮あゆみ; 高橋優喜; 和多田正義; 加藤紀彦; 後藤愛那; 片山高嶺; 上村匡; 上村匡; 上村匡; 服部佑佳子

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 個体成長を支える共生酵母・共生細菌の栄養基盤の解析

  牟禮あゆみ; 高橋優喜; 和多田正義; 加藤紀彦; 後藤愛那; 片山高嶺; 上村匡; 上村匡; 上村匡; 服部佑佳子

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 腸内細菌のムチン分解機序

  加藤 紀彦; 片山 高嶺

  01 Feb. 2024

  
• Discovery and analysis of novel degradation pathway of sulfated mucin O-glycan by gut microbes

  加藤紀彦; 山田千早; 伏信進矢; 片山高嶺

  生化学, 2024

  
• 日本から発信されたサイエンス(No.51)ビフィズス菌由来スルフォグリコシダーゼの解析からみえてきた腸内細菌によるムチン糖鎖分解 : Katoh T, Yamada C, Wallace MD et al : A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem. Nat Chem Biol 19 : 778-789, 2023

  加藤 紀彦; 片山 高嶺

  消化器病学サイエンス = Science of gastroenterology / 「消化器病学サイエンス」編集委員会 編, Dec. 2023

  
• 腸内ビフィズス菌による硫酸化ムチン糖鎖の分解メカニズム

  加藤 紀彦; 片山 高嶺

  バイオサイエンスとインダストリー, Nov. 2023

  
• 腸管上皮細胞と嫌気性腸内細菌の共培養システムの評価

  高橋 実花子; 米田 恭子; 藤山 陽一; 後藤 愛那; 加藤 紀彦; 片山 高嶺; 長谷 耕二; 金 倫基; 橋本 豊之

  腸内細菌学雑誌, Apr. 2023

  
• 腸内細菌の硫酸化ムチン糖鎖資化戦略-ビフィズス菌を例に-

  加藤紀彦

  応用糖質科学, 2023

  
• 腸内細菌由来グリコシダーゼを用いたムチン脱グリコシル化のための酵素ツールの構築

  桝本麗花子; 芦田久; 片山高嶺; 加藤紀彦

  応用糖質科学, 2023

  
• Structural Basis of Glycosyl Hydrolases that Degrade Sulfated Mucin Glycans and Blood Group Antigens from Bifidobacterium bifidum

  鹿島騰真; 加藤紀彦; 山田千早; 片山高嶺; 芦田久; 伏信進矢; 伏信進矢

  応用糖質科学, 2023

  
• [Review] Studies on Structural and Functional Diversity of Mucin Glycans and Glycan Synthesis by Applying Microbial Enzymes

  Katoh Toshihiko

  Bulletin of Applied Glycoscience, 20 Feb. 2022

  
• ムチン研究ツールとしてのビフィズス菌糖質分解酵素群に関する研究

  加藤 紀彦

  研究報告書 三島海雲記念財団 [編], 2020

  
• シグレックとムチン糖鎖の相互作用を介した炎症抑制機構—ムチン糖鎖のアレルギー性免疫応答における役割

  加藤 紀彦

  化学と生物, 2016

  
• Generation and metabolism of cytosolic free oligosaccharides in caenorhabditis elegans

  Toshihiko Katoh; Ashida Hisashi; Yamamoto Kenji

  Trends in Glycoscience and Glycotechnology, May 2009

  
• 2P-280 Systematic chemical synthesis of N-glycan series & Chemoenzymatic transglycosylation by Glycosynthase

  Ishida Hideki; Nishikawa Yoshihide; Ota Takashi; Ishihara Mikio; Iino Kenta; Saburoumaru Miyuki; Kumada Junichi; Habu Masato; Tanji Takahiro; Yuasa Noriyuki; Iwaki Jun; Katoh Toshihiko; Yamamoto Kenji; Matsuzaki Yuji

  日本生物工学会大会講演要旨集, 2015

  
• 2P-284 Application of microbial endoglycosidase for bio-medicine production

  Katoh Toshihiko; Sakaguchi Kouta; Chiba Yasunori; Katayama Takane; Kumada Jyunichi; Matsuzaki Yuji; Yamamoto Kenji

  日本生物工学会大会講演要旨集, 2015

  
• Evolutionary traits found in fucosyllactose transporters support symbiosis between bifidobacteria and breast-fed infants

  阪中幹祥; 阪中幹祥; 栗原新; 栗原新; 片山高嶺; 片山高嶺; HANSEN Morten Ejby; 後藤愛那; 加藤紀彦; 吉田圭佑; 小田巻俊孝; 杉山友太; 廣瀬潤子; 浦島匡; 清水(肖)金忠; 北岡本光; 吹谷智; 横田篤; LEGGIO Leila Lo; HACHEM Maher Abou

  Institute for Fermentation, Osaka. Research Communications, 2019

  
• Glycans carried by airway mucins are endogenous ligands for Siglec-F and induce eosinophil apoptosis

  角田 義弥; 際本 拓未; 加藤 紀彦; 檜澤 伸之

  臨床免疫・アレルギー科 = Clinical immunology & allergology, May 2016

  
• Mucin O-glycan assimilation pathway in Bifidobacterium

  CHOI Moonhak; 後藤愛那; 阪中幹祥; 加藤紀彦; 西本完; 杉山友太; 栗原新; 吹谷智; 横田篤; 北岡本光; 片山高嶺

  日本農芸化学会大会講演要旨集(Web), 2021

  
• Use of Gifu Anaerobic Medium for culturing 32 dominant species of human gut microbes and its evaluation based on short-chain fatty acids fermentation profiles.

  後藤愛那; 後藤愛那; 阪中幹祥; 阪中幹祥; 片山高嶺; 片山高嶺; 栗原新; 栗原新; 杉山友太; 奈良未沙希; 南博道; 谷内寛之; 北方彩; 中川明; 奥田修二郎; 加藤紀彦

  Institute for Fermentation, Osaka. Research Communications, 2019

  
• ビフィズス菌におけるラクト-N-テトラオース輸送体の同定およびビフィズスフローラ形成への関与

  阪中 幹祥; 砂川 直輝; 佐藤 真与; 吉田 圭佑; 石田 卓也; 後藤 愛那; 加藤 紀彦; 谷内 寛之; 密山 恵梨; 加藤 久美子; 廣瀬 潤子; 阿部 紘一; 前田 信悟; 杉山 友太; 吹谷 智; 横田 篤; 栗原 新; 荒川 孝俊; 小田巻 俊孝; 清水 金忠; 五十嵐 圭日子; 伏信 進矢; 片山 高嶺

  腸内細菌学雑誌, Apr. 2018

  
• ABCトランスポーターを介したビフィズス菌の糖質取込みを包括的に制御するATP加水分解酵素MsiK

  阪中幹祥; 前田信悟; 後藤愛那; 村上隆太; 加藤紀彦; 杉山友太; 谷内寛之; 栗原新; 玉置尚徳; 吹谷智; 横田篤; 片山高嶺; 片山高嶺

  日本乳酸菌学会誌, 2018

  
• ビフィズス菌由来ATPase MsiKはABCトランスポーターを介した糖質取込みをグローバルに制御する

  前田信悟; 阪中幹祥; 後藤愛那; 村上隆太; 加藤紀彦; 杉山友太; 谷内寛之; 栗原新; 玉置尚徳; 吹谷智; 横田篤; 片山高嶺; 片山高嶺

  日本農芸化学会大会講演要旨集(Web), 2018

  
• Reply

  Bruce S. Bochner; Takumi Kiwamoto; Toshihiko Katoh; Zhou Zhu; Michael Tiemeyer

  Journal of Allergy and Clinical Immunology, 01 Jun. 2015

  
• Eosinophil apoptosis-inducing drugs risk worsening rather than resolving asthma Reply

  Bruce S. Bochner; Takumi Kiwamoto; Toshihiko Katoh; Zhou Zhu; Michael Tiemeyer

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Jun. 2015

  
• N-Glycan Replacement of a Therapeutic Antibody with Structure-defined Glycan by Chemoenzymatic Glycoengineering using Endo-M and Glycosynthase

  Junichi Kumada; Masato Habu; Takahiro Tanji; Noriyuki Yuasa; Jun Iwaki; Toshihiko Katoh; Kenji Yamamoto; Yuji Matsuzaki

  GLYCOBIOLOGY, Nov. 2014

  
• Endogenous airway mucins carry glycans that bind Siglec-F and induce eosinophil apoptosis

  Takumi Kiwamoto; Toshihiko Katoh; Christopher Evans; William Janssen; Mary Brummet; Sherry Hudson; Zhou Zhu; Michael Tiemeyer; Bruce Bochner

  GLYCOBIOLOGY, Nov. 2014

  
• The Airway Mucins Muc5b and Muc4 Are Endogenous Ligands For Siglec-F and Induce Mouse Eosinophil Death

  Takumi Kiwamoto; Toshihiko Katoh; Christopher Evans; Mary E. Brummet; Sherry Hudson; Zhou Zhu; Michael Tiemeyer; Bruce S. Bochner

  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Feb. 2014

  
• 3S-Ea02 Investigation of the regulatory mechanism of inflammation directed to the development of therapeutics for asthma

  Katoh Toshihiko; Kiwamoto Takumi; Evans Christopher; Hudson Sherry; Brummet Mary; Zhu Zhou; Tiemeyer Michael; Bochner Bruce

  日本生物工学会大会講演要旨集, 2014

  
• Further characterization of endogenous mouse lung proteins bearing glycan counter-receptors for Siglec-F

  Toshihiko Katoh; Takumi Kiwamoto; Christopher Evans; Mary Brummet; Sherry Hudson; Zhou Zhu; Bruce Bochner; Michael Tiemeyer

  GLYCOBIOLOGY, Nov. 2013

  
• Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65 (vol 4, pg 1659, 2013)

  Yi Xiang; Xiaoyan Zhang; David B. Nix; Toshihiko Katoh; Kazuhiro Aoki; Michael Tiemeyer; Yanzhuang Wang

  NATURE COMMUNICATIONS, Sep. 2013

  
• Identification of endogenous lung proteins bearing glycan counter-receptors formouse Siglec-F

  Toshihiko Katoh; Takumi Kiwamoto; Mary Brummet; Bruce Bochner; Michael Tiemeyer

  GLYCOBIOLOGY, Nov. 2012

  
• Nervous system-specific sialylation in Drosophila

  Hilary Witzenman; Dmitry Lyalin; Courtney Caster; Michiko Nakamura; Niraj Kc; Rafique Islam; Toshihiko Katoh; Mark Zoran; Michael Tiemeyer; Vladislav Panin

  GLYCOBIOLOGY, Nov. 2012

  
• Sialylated Glycoproteins of Drosophila melanogaster

  Toshihiko Katoh; Vladislav Panin; Michael Tiemeyer

  GLYCOBIOLOGY, Nov. 2011

  
• Autonomous and Non-Autonomous Pathways to Neural-Specific Glycosylation

  Michael Tiemeyer; Mary Sharrow; Sarah Baas; Varshika Kotu; Emily King; Maggie Bergmann; Toshihiko Katoh; Kazuhiro Aoki

  GLYCOBIOLOGY, Nov. 2010

  
• A Novel Function of Glucosamine: Activity for Autophagy Induction

  Hisashi Ashida; Tomoya Shintani; Fumiyoshi Yamazaki; Toshihiko Katoh; Midori Umekawa; Kazuhide Totani; Kenji Yamamoto

  The 25th International Carbohydrate Symposium, Aug. 2010

  
• アミノ糖によるオートファジー誘導の解析

  新谷知也; 山崎文義; 加藤紀彦; 梅川碧里; 又平芳春; 垣塚 彰; 戸谷一英; 山本憲二; 芦田 久

  日本農芸化学会関西支部第463回 講演会, 06 Feb. 2010, Peer-reviewed

  
• Extending N-Glycosylation Toward Greater Complexity in a Multicellular Organism

  Toshihiko Katoh; Xianzong Shi; Ahmed Mohammed; Jason R. Hollister; J. Joe Hull; Longhau Sun; Malcolm J. Fraser; Joseph O'tousa; Michael Tiemeyer; Donald L. Jarvis

  GLYCOBIOLOGY, Nov. 2009

  
• Re-Visiting the Endogenous Capacity for Recombinant Glycoprotein Sialylation by Baculovirus-Infected Tn-4h and Dpn1 Cells

  Donald L. Jarvis; Hillar Alex; Toshihiko Katoh; Michael Tiemeyer

  GLYCOBIOLOGY, Nov. 2009

  
• Generation and Metabolism of Cytosolic Free Oligosaccharides in Caenorhabditis elegans

  Toshihiko Katoh; Hisashi Ashida; Kenji Yamamoto

  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, May 2009

  
• The Complexities of Fucosylation in Drosophila

  Michael Tiemeyer; Mary Sharrow; Sarah Baas; Kazuhiro Aoki; Mindy Porterfield; Toshihiko Katoh; Katherine H. McGlamry; Khoi Nguyen; Brian Dong; Samuel S. Lee

  GLYCOBIOLOGY, Nov. 2008

  
• The sugar-free frosting Mutation Links Glycosylation and Biogenic Amine Metabolism

  Sarah Baas; Toshihiko Katoh; Mary Sharrow; Khoi Nguyen; Kazuhiro Aoki; Michael Tiemeyer

  GLYCOBIOLOGY, Nov. 2008

  
• Presence of transglycosylation activity of endoglycosidase in higher organisms

  KATO Toshihiko; YAMAMOTO Kenji

  バイオサイエンスとインダストリー = Bioscience & industry, 01 Feb. 2003

  

Presentations

• 硫酸化ムチン糖鎖の分解に関わる腸内細菌由来酵素の解析

  加藤紀彦

  糖質関連酵素研究の若手シンポジウム, 28 Mar. 2024, Invited

  
• A sulfoglycosidase from Bifidobacterium bifidum is involved in the degradation of sulfated mucin O-glycans in the intestine

  Toshihiko Katoh; Chihaya Yamada; Toma Kashima; Mikiyasu Sakanaka; Ikuo Kimura; Keith A. Stubbs; Shinya Fushinobu; Takane Katayama

  SfG-2023 Annual Meeting, 07 Nov. 2023

  
• 腸内細菌の硫酸化ムチン糖鎖資化戦略—ビフィズス菌を例に—

  加藤紀彦

  日本応用糖質科学会2023年度大会（第72回）応用糖質科学シンポジウム, 15 Sep. 2023

  
• 腸内細菌由来スルフォグリコシダーゼによる 腸管内でのムチン糖鎖分解

  加藤 紀彦; 山田 千早; 鹿島 騰真; 高田 紘翠; 阪中 幹祥; 木村 郁夫; Keith A. Stubb; 伏信 進矢; 片山 高嶺

  第42会日本糖質学会, 08 Sep. 2023

  
• Bifidobacterium bifidum Degrades Sulfated Mucin O-Glycans Via a Sulfatase-independent Pathway

  Toshihiko Katoh; Chihaya Yamada; Michael D. Wallace; Aina Gotoh; Toma Kashima; Miriam N. Ojima; Hiromi Takada; Mikiyasu Sakanaka; Masanori Yamaguchi; Hisashi Ashida; Junko Hirose; Maria Suarez-Diez; Ikuo Kimura; Keith A. Stubbs; Shinya Fushinobu; Takane Katayama

  GLYCO26 Taiwan, 29 Aug. 2023

  
• 加藤紀彦

  第24回酵素応用シンポジウム, 02 Jun. 2023, Invited

  
• Construction of an enzymatic toolkit for de-glycosylation of mucin using bacterial glycosidases

  加藤紀彦

  ノボザイムズジャパン バイオテクノロジーフォーラム2022, 22 Nov. 2022, Invited

  
• Distinct two modes of mucin glycan degradation by gut microbes from the view of enzymatic characteristics

  加藤紀彦

  日本農芸化学会2022年大会, 18 Mar. 2022, Invited

  
• ムチン糖鎖の構造的・機能的多様性の解析と微生物酵素の応用による糖鎖合成研究

  加藤紀彦

  日本応用糖質科学会第47回近畿支部会, 26 Nov. 2021, Invited

  
• 腸内細菌によるムチン分解機構

  加藤紀彦

  第62回 日本生化学会 中国・四国支部例会 シンポジウム ：「糖鎖生物学のフロンティア」, 10 Sep. 2021, Invited

  
• ムチン糖鎖の構造的・機能的多様性の解析と微生物酵素の応用による糖鎖合成研究

  加藤紀彦

  日本応用糖質科学会2021年度大会, 01 Sep. 2021, Invited

  
• Bifidobacterium bifidumによるムチン糖鎖分解と硫酸化糖の代謝

  加藤紀彦

  ビフィズス菌研究会第１回シンポジウム, 12 Mar. 2021, Invited

  
• Bifidobacterium bifidum由来スルフォグリコシダーゼBbhIIの糖鎖結合ドメインの機能解析

  荒井 萌; 加藤 紀彦; 山田 千早; 前渋 貴子; 吉田 彩子; 西山 真; 伏信 進矢; 片山 高嶺

  日本農芸化学会2020年度大会, 28 Mar. 2020

  
• ムチン糖タンパク質糖鎖の腸内細菌による分解

  高田 紘翠; 加藤 紀彦; 片山 高嶺

  日本農芸化学会関西支部例会（第512回講演会）, 01 Feb. 2020

  
• ビフィズスフローラ形成に関与するオリゴ糖分解酵素群

  加藤紀彦

  京都バイオ計測センター研究交流会, 15 Oct. 2019, Invited

  
• 宿主由来オリゴ糖利用によるビフィズス菌叢形成メカニズム

  加藤 紀彦

  第92回日本生化学会大会, 19 Sep. 2019, Invited

  
• Enzymatic synthesis of lacto-N-tetraose, a core structure of human milk oligosaccharide, using mutant phosphorylase

  Toshihiko Katoh; Aina Gotoh; Tsubasa Norioka; Motomitsu Kitaoka; 〇Takane Katayama

  The 1st Japan-Switzerland-Germany workshop for enzyme technology and bioprocess development, 11 Sep. 2019

  
• ビフィズス菌のオリゴ糖資化・代謝メカニズム

  加藤 紀彦

  おかやまバイオアクティブ研究会第５５回シンポジウム, 09 Jul. 2019, Invited

  
• Probiotic Bifidobacterium bifidum Alters the Gut Microbiome after Repeated Antibiotic Disturbance but Contributes to the Recovery of Host Health

  Miriam N. Ojima; Aina Gotoh; Hiromi Takada; Toshihiko Katoh; Takane Katayama

  ASM Microbe, 21 Jun. 2019

  
• Bifidobacterium bifidum由来スルフォグリコシダーゼBbhIIのX線結晶構造解析

  加藤紀彦; 山田千早; 前渋貴子; 芦田 久; 伏信進矢; 片山高嶺

  日本農芸化学会2019年度大会, 24 Mar. 2019

  
• ムチン資化性菌Bifidobacterium bifidumが産生するスルフォグリコシダーゼの機能解析

  前渋貴子; 加藤紀彦; 後藤愛那; 山口真範; 芦田久; 山本憲二; 片山高嶺

  応用糖質科学会第44回近畿支部会, 07 Nov. 2018

  
• A mucin-degrading sulfoglycosidase from bifidobacteria

  Toshihiko Katoh

  日本農芸化学会関西・中四国・西日本支部2017年度合同大阪大会, 22 Sep. 2017

  
• ムチンの硫酸化糖鎖に作用するビフィズス菌由来スルフォグリコシダーゼ

  加藤紀彦; 前渋貴子; 吉川慶一; 後藤愛那; 山口真範; 芦田久; 山本憲二; 片山高嶺

  第１８回 関西グライコサイエンスフォーラム, 13 May 2017

  
• Identification and characterization of a mucin-degrading sulfoglycosidase from Bifidobacteria

  加藤 紀彦; 前渋 貴子; 吉川 慶一; 後藤 愛那; 苫米地 祐輔; 芦田 久; 山本憲二; 片山 高嶺

  日本農芸化学会2017年大会, 18 Mar. 2017

  
• フコシル化糖タンパク質合成に向けた高効率1,2-α-L-フコシンターゼの作出

  加藤紀彦; 杉山友太; 後藤愛那; 本多裕司; 芦田久; 北岡本光; 山本憲二; 片山高嶺

  第７回グライコバイオロジクス研究会, 25 Oct. 2016

  
• Generation of Endo-M mutant that acts on core-fucosylated N-glycans

  加藤紀彦; 片山高嶺; 苫米地祐輔; 岩城隼; 熊田純一; 松崎祐二; 山本憲二

  第35回日本糖質学会年会, 03 Sep. 2016

  
• 部位特異的変異導入によるエンドグリコシダーゼの糖鎖特異性の改変

  加藤紀彦; 山本憲二

  日本農芸化学会2016年度大会, 29 Mar. 2016

  

Books and Other Publications

• 中分子創薬に資するペプチド・核酸・糖鎖の合成技術

  加藤紀彦; 山本憲二, Contributor, 第10章 Endo-M酵素による糖鎖付加と均一化

  シーエムシー出版, Feb. 2018, Not refereed

  
• Glycoscience : biology and medicine

  Toshihiko Katoh; Kenji Yamamoto, Contributor, Chapter 47, Glycoenzymes in Glycan Analysis and Synthesis

  Springer, 2015

  Find Kyoto University's collection of books :

  
• Comprehensive glycoscience : from chemistry to systems biology

  Hisashi Ashida; Toshihiko Kato; Kenji Yamamoto, Contributor, 3.09 Degradation of Glycoproteins

  Elsevier, 2007

  Find Kyoto University's collection of books :

  

Industrial Property Rights

• 特許第6830576号, 特願2017-502530, エンドM変異体、及びN結合型糖鎖含有化合物又はN結合型糖鎖含有蛋白質の製造方法

  山本 憲二; 加藤 紀彦

  
• WO2020-040257, JP2019032866, 改変ホスホリラーゼを利用したラクト-N-ビオースIまたはガラクト-N-ビオースのβグリコシドの酵素合成法

  片山 高嶺; 加藤 紀彦; 北岡 本光

  

Awards

• 02 Jun. 2023

  第24回酵素応用シンポジウム研究奨励賞(天野エンザイム科学技術振興財団)
• 15 Mar. 2018

  Japan Society for Bioscience, Biotechnology, and Agrochemistry (NIPPON NOGEIKAGAKU KAI), Award for Excellence to Authors Publishing in Bioscience, Biotechnology, and Biochemistry in 2017
• 01 Jun. 2021

  The Japanese Society of Applied Glycoscience, 日本応用糖質科学会奨励賞

External funds: Kakenhi

• Physiological role of bifidus flora formation in breast-fed infant guts

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  Takane Katayama

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  母乳;母乳オリゴ糖;インドール乳酸;腸内細菌;ビフィズス菌;芳香族乳酸;ビフィズスフローラ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22277/
• Functional analysis and application of sulfoglycosidase from mucin-assimilating bacteria

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38020:Applied microbiology-related

  Kyoto University

  Toshihiko Katoh

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  ムチン;Bifidobacterium bifidum;糖鎖;スルフォグリコシダーゼ;グライコミクス;CBM;GH20;O-glycan;腸内細菌;BbhII;GH;Bfidobacterium bifidum;ビフィズス菌;sulfoglycosidase;Bifidobacterium;sulfated glycan

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K05789/
• Development of an in vitro co-culture system for elucidation of host-gut microbiota symbiotsis

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38020:Applied microbiology-related

  Kyoto University

  Takane Katayama

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  共培養;アピカル嫌気;嫌気性細菌;腸上皮細胞;腸管上皮細胞;偏性嫌気性細菌;腸上皮細胞株;共生;腸内細菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02126/
• Host-microbe symbiosis mediated through symbiogenic factors

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyoto University

  Takane Katayama

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  母乳オリゴ糖;ビフィズス菌;ラクト-N-テトラオース;シンビオジェニック因子;水酸化脂肪酸;共生;クロストーク;腸内細菌;宿主

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19231/
• Functional analysis and application studies of gut microbe-derived sulfoglycosidase and sulfated mucin in symbiosis

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Toshihiko Katoh

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  スルフォグリコシダーゼ;ビフィズス菌;糖質分解酵素;ムチン;硫酸化糖鎖;sulfoglycosidase;Bifidobacterium bifidum;sulfated glycan;腸内細菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K17820/
• Innovative technique for production of biomedicines with uniform sugar chains by use of microbial enzymes

  Grant-in-Aid for Scientific Research (C)

  Ishikawa Prefectural University

  Kenji Yamamoto

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  バイオ医薬品;糖鎖;エンドグリコシダーゼ;糖転移反応;リモデリング;インターフェロン-γ;インターロイキン-３;Pichia pastoris;エンドーＭ;インターロイキン３;インターフェロンーγ;エンド-M;インターロイキン-3;エンド-Ｍ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07698/
• Development of the innovative technique for addition of sugar chain using microbial enzymes and its application on the syntheses of functional glycoconjugates

  Grant-in-Aid for Scientific Research (B)

  Ishikawa Prefectural University

  Kenji YAMAMOTO

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  エンドグリコシダーゼ;糖転移反応;糖鎖付加;糖鎖リモデリング;オキサゾリン化合物;免疫グロブリンＧ;コアフコース;細胞傷害活性;抗体医薬;免疫グロブリンG;Endo-M;部位特異的変異酵素;イムノグロブリンG;グライコシンターゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25292063/
• Molecular mechanism and its physiological significance of metal coordination in Tyrosinase family proteins

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38030:Applied biochemistry-related

  Kyoto University

  神戸 大朋

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  メラニン色素;チロシナーゼファミリー;亜鉛;銅;トランスポーター;チロシナーゼ酵素群;亜鉛輸送体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02257/
• Elucidation of mechanisms for human-microbiome symbiosis mediated by the sulfated mucin glycan-terminal structures

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38020:Applied microbiology-related

  Kyoto University

  加藤 紀彦

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  糖質分解酵素;ムチン;腸内細菌;糖鎖;糖鎖結合ドメイン;ビフィズス菌;糖質加水分解酵素;Mucin;Glycan;microbiome;Bifidobacterium bifidum;glycoside hydrolase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05009/
• Metal coordination mechanism of Tyrosinase family members essential for melanin biosynthesis

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38030:Applied biochemistry-related

  Kyoto University

  神戸 大朋

  From 01 Apr. 2024, To 31 Mar. 2025, Project Closed

  メラニン色素;チロシナーゼ;TYRP1;亜鉛;銅;チロシナーゼファミリー;トランスポーター;チロシナーゼ酵素群;亜鉛輸送体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K23524/
• Elucidation of the molecular mechanism by which pathogenic bacteria utilize intestinal glycans to evade host immunity

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  加藤 紀彦

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  Glycan;Gut microbe;Lectin

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25H01432/
• 腸内糖鎖ダイアローグ領域研究の推進

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Gifu University

  藤田 盛久

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  腸内細菌;腸管免疫;ムチン型糖鎖;ヒトミルクオリゴ糖;分岐型アミノ酸

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-25H01429/
• Bifidobacterium属細菌に見出したインドールサルベージ経路の生理機能実証と探索研究

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  片山 高嶺

  From 27 Jun. 2025, To 31 Mar. 2027, Granted

  インドール

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K22329/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Interdisciplinary Sciences

  Y101, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Practice in Biology I

  N420, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Life Science: From Basics to Applications, from Molecular Biology to Systems Biology

  1026, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Experiments in Integrated Life Sciences

  5012, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Experiments in Integrated Life Sciences

  5012, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Life Science: From Basics to Applications, from Molecular Biology to Systems Biology

  1026, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Integrated Life Sciences

  5012, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Integrated Life Sciences

  5012, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Life Science: From Basics to Applications, from Molecular Biology to Systems Biology

  1026, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Life Science: From Basics to Applications, from Molecular Biology to Systems Biology

  1026, Spring, Graduate School of Biostudies, 1
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  ILAS Seminar : enzymes in everyday everywhere

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  ILAS Seminar : enzymes in everyday and everywhere

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Life Science: From Basics to Applications, from Molecular Biology to Systems Biology

  Spring, 生命科学研究科

Administration

Faculty management (title, position)

• From 01 Apr. 2021

  動物実験委員会

Academic, Social Contribution

Committee Memberships

• From Jul. 2021, To Jun. 2023

  常任幹事, 日本応用糖質科学会近畿支部