Basic Information

Professional Memberships

• From Dec. 2019, To Present

  Japanese Association for Medical Artificial Intelligence
• 日本RNA学会

Academic Degree

• 25 Mar. 2002

  名古屋大学修士（理学）
• 31 Jul. 2006

  名古屋大学博士（理学）
• 修士（理学）(名古屋大学)
• 博士（理学）(名古屋大学)

Academic Resume (Graduate Schools)

• 名古屋大学, 大学院理学研究科生命理学専攻博士前期課程, 修了

Academic Resume (Undergraduate School/Majors)

• 名古屋大学, 理学部生命理学科, 卒業

Research History

• From Apr. 2024, To Present

  Kyoto University, Center for Cancer Immunotherapy and Immunobiology（CCII）, 特定准教授（クロスアポイントメント）
• From Jun. 2022, To Mar. 2024

  京都大学 iPS細胞研究所, 研究員(非常勤)
• From Apr. 2022, To Present

  Kyoto University, Graduate School of Medicine, Visiting Researcher
• From Apr. 2022, To Present

  Kindai University, Faculty of Science and Engineering, Lecturer
• From Sep. 2012, To Mar. 2022

  Kyoto University, Graduate School of Medicine, Research Assistant Professor
• From Dec. 2008, To Aug. 2012

  RIKEN, BASE
• From Apr. 2007, To Nov. 2008

  University of California, Riverside
• From Apr. 2004, To Mar. 2007

  Nagahama Institute of Bio-Science and Technology, Faculty of Bio-Science
• From Apr. 2002, To Mar. 2004

  理化学研究所, ゲノム科学研究センター

ID,URL

• ORCID ID

  0000-0001-7130-8705

• J-Global ID

  200901087903479252

• External link

  https://keiiida.github.io/

Website(s) (URL(s))

• https://keiiida.github.io/

researchmap URL

• https://researchmap.jp/read0118609

Research

Research Interests

• Cancer immunology
• ALS
• sinlge cell RNA-seq
• RNA結合タンパク質
• エピトランスクリプトーム
• transcriptome
• 選択的スプライシング
• 情報生物学

Research Areas

• Life sciences, Systems genomics, データサイエンス

Papers

• Invention of an oral medication for cardiac Fabry disease caused by RNA mis-splicing

  Tomonari Awaya; Teruo Sawada; Megumu Saito; Masatoshi Hagiwara; Masahiko Ajiro; Kei IIDA; Hiroko Kobayashi; Kentoku Gotanda; Toshiharu Noji; Naohiro Takemoto; Dau-Ming Niu

  Science Advances, 09 Apr. 2025

  
• Switching of OAS1 splicing isoforms overcomes SNP-derived vulnerability to SARS-CoV-2 infection

  Kei Iida; Masahiko Ajiro; Akiko Nakano-Kobayashi; Yukiko Muramoto; Toru Takenaga; Masatsugu Denawa; Ryo Kurosawa; Takeshi Noda; Masatoshi Hagiwara

  BMC Biology, 03 Mar. 2025

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• Arabidopsis whole genome expression profiling under abiotic stress conditions

  Seki, M; Ishida, J; Morosawa, T; Matsui, A; Kim, JM; Nakajima, M; Enju, A; To, T; Iida, K; Go, M; Mochizuki, Y; Hasegawa, Y; Toyoda, T; Shinozaki, K

  Plant and Cell Physiology, 2006, Peer-reviewed

  
• PDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing

  Ryo Kurosawa; Kei Iida; Masahiko Ajiro; Tomonari Awaya; Mamiko Yamada; Kenjiro Kosaki; Masatoshi Hagiwara

  BMC Genomics, 10 Oct. 2023

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• Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection

  Kei Iida; Masahiko Ajiro; Yukiko Muramoto; Toru Takenaga; Masatsugu Denawa; Ryo Kurosawa; Takeshi Noda; Masatoshi Hagiwara

  23 Aug. 2021

  
• Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches

  Misa Minegishi; Takahiro Kuchimaru; Kaori Nishikawa; Takayuki Isagawa; Satoshi Iwano; Kei Iida; Hiromasa Hara; Shizuka Miura; Marika Sato; Shigeaki Watanabe; Akifumi Shiomi; Yo Mabuchi; Hiroshi Hamana; Hiroyuki Kishi; Tatsuyuki Sato; Daigo Sawaki; Shigeru Sato; Yutaka Hanazono; Atsushi Suzuki; Takahide Kohro; Tetsuya Kadonosono; Tomomi Shimogori; Atsushi Miyawaki; Norihiko Takeda; Hirofumi Shintaku; Shinae Kizaka-Kondoh; Satoshi Nishimura

  Nature Communications, 05 Dec. 2023

  
• Sfpq-KOマウスをモデルとした骨格筋代謝-筋量制御ネットワークの解析

  細川 元靖; 武内 章英; 谷端 淳; 飯田 慶; 武田 伸一; 萩原 正敏

  日本筋学会学術集会プログラム・抄録集, Aug. 2019

  
• CCL21‐Ser expression in melanoma cells recruits CCR7+ naïve T cells to tumor tissues and promotes tumor growth

  Megumi Miyamoto; Yuki Kawato; Ryonosuke Fujie; Kaoru Kurowarabe; Kakeru Fujiwara; Reika Nobusawa; Ryota Hayashi; Kei Iida; Izumi Ohigashi; Haruko Hayasaka

  Cancer Science, 08 Jul. 2023, Peer-reviewed

  
• Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease

  Jiandong Yang; Yoshikazu Hirai; Kei Iida; Shinji Ito; Marika Trumm; Shiho Terada; Risako Sakai; Toshiyuki Tsuchiya; Osamu Tabata; Ken-ichiro Kamei

  Communications Biology, 23 Mar. 2023, Peer-reviewed

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• Identification of the α2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft models

  Takahiro Nagai; Naoki Terada; Masato Fujii; Yasuhisa Nagata; Kozue Nakahara; Shoichiro Mukai; Kosuke Okasho; Yuki Kamiyama; Shusuke Akamatsu; Takashi Kobayashi; Kei Iida; Masatsugu Denawa; Masatoshi Hagiwara; Takahiro Inoue; Osamu Ogawa; Toshiyuki Kamoto

  Cancer Reports, 09 Aug. 2022

  
• Involvement of endothelins in neuroprotection of valosin-containing protein modulators against retinal ganglion cell damage

  Mami Kusaka; Tomoko Hasegawa; Hanako Ohashi Ikeda; Yumi Inoue; Sachiko Iwai; Kei Iida; Akitaka Tsujikawa

  Scientific Reports, 28 Sep. 2022

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• Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer

  Shingo Matsushima; Masahiko Ajiro; Kei Iida; Kenji Chamoto; Tasuku Honjo; Masatoshi Hagiwara

  Science Translational Medicine, 30 Nov. 2022

  
• Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding

  Yusuke Takashima; Asako Murata; Kei Iida; Ayako Sugai; Masatoshi Hagiwara; Kazuhiko Nakatani

  ACS CHEMICAL BIOLOGY, Sep. 2022

  
• 急性網膜神経節細胞障害モデルを用いたVCP ATPase阻害剤の神経保護メカニズム

  日下 真実; 長谷川 智子; 池田 華子; 岩井 祥子; 飯田 慶; 垣塚 彰; 辻川 明孝

  日本眼科学会雑誌, Mar. 2021

  
• Localization of Ca-, Zn-and Mg-ligands to a limited number of modules

  Iida K.; Matsui N.; Yura K; Go M.

  Seibutsu Butsuri, 2000

  
• Versatility of RNA-Binding Proteins in Living Cells

  Riki Kurokawa; Akihide Takeuchi; Nobuyuki Shiina; Masato Katahira; Takefumi Yamashita; Yoko Matsuno; Keisuke Hitachi; Shinsuke Ishigaki; Nesreen Haamad; Ryoma Yoneda; Naomi Ueda; Kei Iida; Motoyasu Hosokawa; Masatoshi Hagiwara; Mamiko Iida; Tsukasa Mashima; Yudai Yamaoki; Masatomo So; Takashi Nagata; Gen Sobue; Keiko Kondo; Hiroki Watanabe; Takayuki Uchihashi

  Biomedical Sciences, 2019, Peer-reviewed

  
• 3P288 Shift of alternative splicing profiles on Arabidopsis thaliana transcriptome under cold stress

  Iida K.; Seki M.; Sakurai T.; Satou M.; Akiyama K.; Toyoda T.; Konagaya A.; Shinozaki K.

  Seibutsu Butsuri, 2004

  
• Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.

  Masahiko Ajiro; Tomonari Awaya; Young Jin Kim; Kei Iida; Masatsugu Denawa; Nobuo Tanaka; Ryo Kurosawa; Shingo Matsushima; Saiko Shibata; Tetsunori Sakamoto; Rolenz Studer; Adrian R Krainer; Masatoshi Hagiwara

  Nature communications, 23 Jul. 2021

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• CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer

  Simon Uzor; Sean R. Porazinski; Ling Li; Bethany Clark; Masahiko Ajiro; Kei Iida; Masatoshi Hagiwara; Abdullah A. Alqasem; Claire M. Perks; Ian D. Wilson; Sebastian Oltean; Michael R. Ladomery

  Scientific Reports, 12 Apr. 2021, Peer-reviewed

  
• Improvement of Moloney murine leukemia virus reverse transcriptase thermostability by introducing a disulfide bridge in the ribonuclease H region

  Yutaro Narukawa; Mako Kandabashi; Tongyang Li; Misato Baba; Haruka Hara; Kenji Kojima; Kei Iida; Takayoshi Hiyama; Sho Yokoe; Tomomi Yamazaki; Teisuke Takita; Kiyoshi Yasukawa

  Protein Engineering, Design and Selection, 15 Feb. 2021, Peer-reviewed

  
• S1PR3–G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation

  Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara

  Cell Chemical Biology, Feb. 2021, Peer-reviewed

  
• Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage

  Akihide Takeuchi; Yuji Takahashi; Kei Iida; Motoyasu Hosokawa; Koichiro Irie; Mikako Ito; J.B. Brown; Kinji Ohno; Kinichi Nakashima; Masatoshi Hagiwara

  Stem Cell Reports, Oct. 2020, Peer-reviewed

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• Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ

  Kei Iida; Masatoshi Hagiwara; Akihide Takeuchi

  iScience, Jul. 2020, Peer-reviewed

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• Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model.

  Tomoko Hasegawa; Hanako Ohashi Ikeda; Norimoto Gotoh; Kei Iida; Sachiko Iwai; Noriko Nakano; Akira Kakizuka; Akitaka Tsujikawa

  Scientific reports, 06 Mar. 2020, Peer-reviewed

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• Integrative network analysis reveals biological pathways associated with Williams syndrome

  Ryo Kimura; Vivek Swarup; Kiyotaka Tomiwa; Michael J. Gandal; Neelroop N. Parikshak; Yasuko Funabiki; Masatoshi Nakata; Tomonari Awaya; Takeo Kato; Kei Iida; Shin Okazaki; Kanae Matsushima; Toshihiro Kato; Toshiya Murai; Toshio Heike; Daniel H. Geschwind; Masatoshi Hagiwara

  Journal of Child Psychology and Psychiatry, May 2019, Peer-reviewed

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• Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy

  Motoyasu Hosokawa; Akihide Takeuchi; Jun Tanihata; Kei Iida; Shin'ichi Takeda; Masatoshi Hagiwara

  iScience, Mar. 2019, Peer-reviewed

  
• Accurate fidelity analysis of the reverse transcriptase by a modified next-generation sequencing.

  Hiroyuki Okano; Misato Baba; Ryota Hidese; Kei Iida; Tongyang Li; Kenji Kojima; Teisuke Takita; Itaru Yanagihara; Shinsuke Fujiwara; Kiyoshi Yasukawa

  Enzyme and microbial technology, Aug. 2018, Peer-reviewed

  
• Synaptic N6-methyladenosine (m6A) epitranscriptome reveals functional partitioning of localized transcripts

  Daria Merkurjev; Wan-Ting Hong; Kei Iida; Ikumi Oomoto; Belinda J. Goldie; Hitoshi Yamaguti; Takayuki Ohara; Shin-ya Kawaguchi; Tomoo Hirano; Kelsey C. Martin; Matteo Pellegrini; Dan Ohtan Wang

  Nature Neuroscience, 27 Jun. 2018, Peer-reviewed

  
• SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology.

  Mahmoud N Abdelmoez; Kei Iida; Yusuke Oguchi; Hidekazu Nishikii; Ryuji Yokokawa; Hidetoshi Kotera; Sotaro Uemura; Juan G Santiago; Hirofumi Shintaku

  Genome biology, 06 Jun. 2018, Peer-reviewed

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• Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain.

  Akihide Takeuchi; Kei Iida; Toshiaki Tsubota; Motoyasu Hosokawa; Masatsugu Denawa; J B Brown; Kensuke Ninomiya; Mikako Ito; Hiroshi Kimura; Takaya Abe; Hiroshi Kiyonari; Kinji Ohno; Masatoshi Hagiwara

  Cell reports, 01 May 2018, Peer-reviewed

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• Next-generation sequencing-based analysis of reverse transcriptase fidelity.

  Kiyoshi Yasukawa; Kei Iida; Hiroyuki Okano; Ryota Hidese; Misato Baba; Itaru Yanagihara; Kenji Kojima; Teisuke Takita; Shinsuke Fujiwara

  Biochemical and biophysical research communications, 14 Oct. 2017, Peer-reviewed

  
• Novel Stress-Inducible Antisense RNAs of Protein-Coding Loci Are Synthesized by RNA-Dependent RNA Polymerase.

  Akihiro Matsui; Kei Iida; Maho Tanaka; Katsushi Yamaguchi; Kayoko Mizuhashi; Jong-Myong Kim; Satoshi Takahashi; Norio Kobayashi; Shuji Shigenobu; Kazuo Shinozaki; Motoaki Seki

  Plant physiology, Sep. 2017, Peer-reviewed

  
• DNA hypermethyation and silencing of PITX1 correlated with advanced stage and poor postoperative prognosis of esophageal squamous cell carcinoma.

  Otsubo T; Yamada K; Hagiwara T; Oshima K; Iida K; Nishikata K; Toyoda T; Igari T; Nohara K; Yamashita S; Hattori M; Dohi T; Kawamura YI

  Oncotarget, Sep. 2017, Peer-reviewed

  
• Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression

  Bao Ngoc Nguyen; Yukiko Okuno; Masahiko Ajiro; Kei Iida; Masatsugu Denawa; Makoto Yamamoto; Naoya Sakamoto; Hiroyuki Kagechika; Masatoshi Hagiwara

  Journal of Medical Virology, 01 Jul. 2017, Peer-reviewed

  
• Synthetic ligand promotes gene expression by affecting GC sequence in promoter

  Saki Matsumoto; Kei Iida; Asako Murata; Masatsugu Denawa; Masatoshi Hagiwara; Kazuhiko Nakatani

  Bioorganic and Medicinal Chemistry Letters, 2017, Peer-reviewed

  
• Sm-like protein-mediated RNA metabolism is required for heat stress tolerance in Arabidopsis

  Masanori Okamoto; Akihiro Matsui; Maho Tanaka; Taeko Morosawa; Junko Ishida; Kei Iida; Yoshiki Mochizuki; Tetsuro Toyoda; Motoaki Seki

  Frontiers in Plant Science, 21 Jul. 2016, Peer-reviewed

  
• On-the-fly selection of cell-specific enhancers, genes, miRNAs and proteins across the human body using SlideBase

  Hans Ienasescu; Kang Li; Robin Andersson; Morana Vitezic; Sarah Rennie; Yun Chen; Kristoffer Vitting-Seerup; Emil Lagoni; Mette Boyd; Jette Bornholdt; Michiel J. L. De Hoon; Hideya Kawaji; Timo Lassmann; Yoshihide Hayashizaki; Alistair R. R. Forrest; Piero Carninci; Albin Sandelin

  Database, 01 Jan. 2016, Peer-reviewed

  
• Next-generation sequencing-based comprehensive molecular analysis of 43 Japanese patients with cone and cone-rod dystrophies.

  Maho Oishi, Akio Oishi, Norimoto Gotoh, Ken Ogino, Koichiro Higasa, Kei Iida, Yukiko Makiyama, Satoshi Morooka, Fumihiko Matsuda, Nagahisa Yoshimura

  Molecular vision, 2016, Peer-reviewed

  
• The Constrained Maximal Expression Level Owing to Haploidy Shapes Gene Content on the Mammalian X Chromosome

  Laurence D. Hurst; Avazeh T. Ghanbarian; Alistair R. R. Forrest; FANTOM consortium; Lukasz Huminiecki; Michael Rehli; J. Kenneth Baillie; Michiel J. L. de Hoon; Vanja Haberle; Timo Lassmann; Ivan V. Kulakovskiy; Marina Lizio; Masayoshi Itoh; Robin Andersson; Christopher J. Mungall; Terrence F. Meehan; Sebastian Schmeier; Nicolas Bertin; Mette Jørgensen; Emmanuel Dimont; Erik Arner; Christian Schmidl; Ulf Schaefer; Yulia A. Medvedeva; Charles Plessy; Morana Vitezic; Jessica Severin; Colin A. Semple; Yuri Ishizu; Robert S. Young; Margherita Francescatto; Intikhab Alam; Davide Albanese; Gabriel M. Altschuler; Takahiro Arakawa; John A.C. Archer; Peter Arner; Magda Babina; Sarah Baker; Piotr J. Balwierz; Anthony G. Beckhouse; Swati-Bhatt Pradhan; Judith A. Blake; Antje Blumenthal; Beatrice Bodega; Alessandro Bonetti; James Briggs; Frank Brombacher; A. Maxwell Burroughs; Andrea Califano; Carlo V. Cannistraci; Daniel Carbajo; Yun Chen; Marco Chierici; Yari Ciani; Hans C. Clevers; Emiliano Dalla; Carrie A. Davis; Michael Detmar; Alexander D. Diehl; Taeko Dohi; Finn Drabløs; Albert S.B. Edge; Matthias Edinger; Karl Ekwall; Mitsuhiro Endoh; Hideki Enomoto; Michela Fagiolini; Lynsey Fairbairn; Hai Fang; Mary C. Farach-Carson; Geoffrey J. Faulkner; Alexander V. Favorov; Malcolm E. Fisher; Martin C. Frith; Rie Fujita; Shiro Fukuda; Cesare Furlanello; Masaaki Furuno; Jun-ichi Furusawa; Teunis B. Geijtenbeek; Andrew Gibson; Thomas Gingeras; Daniel Goldowitz; Julian Gough; Sven Guhl; Reto Guler; Stefano Gustincich; Thomas J. Ha; Masahide Hamaguchi; Mitsuko Hara; Matthias Harbers; Jayson Harshbarger; Akira Hasegawa; Yuki Hasegawa; Takehiro Hashimoto; Meenhard Herlyn; Kelly J. Hitchens; Shannan J. Ho Sui; Oliver M. Hofmann; Ilka Hoof; Fumi Hori; Lukasz Huminiecki; Kei Iida; Tomokatsu Ikawa; Boris R. Jankovic; Hui Jia; Anagha Joshi; Giuseppe Jurman; Bogumil Kaczkowski; Chieko Kai; Kaoru Kaida; Ai Kaiho; Kazuhiro Kajiyama; Mutsumi-Katayama Kanamori; Artem S. Kasianov; Takeya Kasukawa; Shintaro Katayama; Sachi Kato; Shuji Kawaguchi; Hiroshi Kawamoto; Yuki I. Kawamura; Tsugumi Kawashima; Judith S. Kempfle; Tony J. Kenna; Juha Kere; Levon M. Khachigian; Toshio Kitamura; S. Peter Klinken; Alan J. Knox; Miki Kojima; Soichi Kojima; Naoto Kondo; Haruhiko Koseki; Shigeo Koyasu; Sarah Krampitz; Atsutaka Kubosaki; Andrew T. Kwon; Jeroen F.J. Laros; Weonju Lee; Andreas Lennartsson; Kang Li; Berit Lilje; Leonard Lipovich; Alan-sim Mackay; Riichiroh Manabe; Jessica C. Mar; Benoit Marchand; Anthony Mathelier; Niklas Mejhert; Alison Meynert; Yosuke Mizuno; David A. de Lima Morais; Hiromasa Morikawa; Mitsuru Morimoto; Kazuyo Moro; Efthymios Motakis; Hozumi Motohashi; Christine L. Mummery; Mitsuyoshi Murata; Sayaka-Sato Nagao; Yutaka Nakachi; Fumio Nakahara; Toshiyuki Nakamura; Yukio Nakamura; Kenichi Nakazato; Erik van Nimwegen; Noriko Ninomiya; Hiromi Nishiyori; Shohei Noma; Tadasuke Nozaki; Soichi Ogishima; Naganari Ohkura; Hiroko Ohmiya; Hiroshi Ohno; Mitsuhiro Ohshima; Mariko-Hatakeyama Okada; Yasushi Okazaki; Valerio Orlando; Dmitry A. Ovchinnikov; Arnab Pain; Robert Passier; Margaret Patrikakis; Helena Persson; Silvano Piazza; James G.D. Prendergast; Owen J.L. Rackham; Jordan A. Ramilowski; Mamoon Rashid; Timothy Ravasi; Patrizia Rizzu; Marco Roncador; Sugata Roy; Morten B. Rye; Eri Saijyo; Antti Sajantila; Akiko Saka; Shimon Sakaguchi; Mizuho Sakai; Hiroki Sato; Hironori Satoh; Suzana Savvi; Alka Saxena; Claudio Schneider; Erik A. Schultes; Gundula G. Schulze-Tanzil; Anita Schwegmann; Thierry Sengstag; Guojun Sheng; Hisashi Shimoji; Yishai Shimoni; Jay W. Shin; Christophe Simon; Daisuke Sugiyama; Takaaki Sugiyama; Masanori Suzuki; Naoko Suzuki; Rolf K. Swoboda; Peter A.C. 't Hoen; Michihira Tagami; Naoko Takahashi; Jun Takai; Hiroshi Tanaka; Hideki Tatsukawa; Zuotian Tatum; Mark Thompson; Hiroo Toyoda; Tetsuro Toyoda; Eivind Valen; Marc van de Wetering; Linda M. van den Berg; Roberto Verardo; Dipti Vijayan; Ilya E. Vorontsov; Wyeth W. Wasserman; Shoko Watanabe; Christine A. Wells; Louise N. Winteringham; Ernst Wolvetang; Emily J. Wood; Yoko Yamaguchi; Masayuki Yamamoto; Misako Yoneda; Yohei Yonekura; Shigehiro Yoshida; Suzan E. Zabierowski; Peter G. Zhang; Xiaobei Zhao; Silvia Zucchelli; Kim M. Summers; Harukazu Suzuki; Carsten O. Daub; Jun Kawai; Peter Heutink; Winston Hide; Tom C. Freeman; Boris Lenhard; Vladimir B. Bajic; Martin S. Taylor; Vsevolod J. Makeev; Albin Sandelin; David A. Hume; Piero Carninci; Yoshihide Hayashizaki

  PLoS Biology, 18 Dec. 2015, Peer-reviewed

  
• Deciphering targeting rules of splicing modulator compounds: Case of TG003

  Maki Sakuma; Kei Iida; Masatoshi Hagiwara

  BMC Molecular Biology, 24 Sep. 2015, Peer-reviewed

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• Loss of Arabidopsis 5′–3′ Exoribonuclease AtXRN4 Function Enhances Heat Stress Tolerance of Plants Subjected to Severe Heat Stress

  Anh Hai Nguyen; Akihiro Matsui; Maho Tanaka; Kayoko Mizunashi; Kentaro Nakaminami; Makoto Hayashi; Kei Iida; Tetsuro Toyoda; Dong Van Nguyen; Motoaki Seki

  Plant and Cell Physiology, Sep. 2015, Peer-reviewed

  
• Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

  Mayumi Yoshida; Naoyuki Kataoka; Kenjyo Miyauchi; Kenji Ohe; Kei Iida; Suguru Yoshida; Takayuki Nojima; Yukiko Okuno; Hiroshi Onogi; Tomomi Usui; Akihide Takeuchi; Takamitsu Hosoya; Tsutomu Suzuki; Masatoshi Hagiwara

  Proceedings of the National Academy of Sciences of the United States of America, 03 Mar. 2015, Peer-reviewed

  
• Comprehensive Molecular Diagnosis of a Large Cohort of Japanese Retinitis Pigmentosa and Usher Syndrome Patients by Next-Generation Sequencing

  Maho Oishi; Akio Oishi; Norimoto Gotoh; Ken Ogino; Koichiro Higasa; Kei Iida; Yukiko Makiyama; Satoshi Morooka; Fumihiko Matsuda; Nagahisa Yoshimura

  Investigative Opthalmology & Visual Science, 19 Nov. 2014, Peer-reviewed

  
• CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

  Makoto Yamamoto; Hiroshi Onogi; Isao Kii; Suguru Yoshida; Kei Iida; Hiroyuki Sakai; Minako Abe; Toshiaki Tsubota; Nobutoshi Ito; Takamitsu Hosoya; Masatoshi Hagiwara

  Journal of Clinical Investigation, 01 Aug. 2014, Peer-reviewed

  
• A promoter-level mammalian expression atlas.

  Alistair R R Forrest; Hideya Kawaji; Michael Rehli; J Kenneth Baillie; Michiel J L de Hoon; Vanja Haberle; Timo Lassmann; Ivan V Kulakovskiy; Marina Lizio; Masayoshi Itoh; Robin Andersson; Christopher J Mungall; Terrence F Meehan; Sebastian Schmeier; Nicolas Bertin; Mette Jørgensen; Emmanuel Dimont; Erik Arner; Christian Schmidl; Ulf Schaefer; Yulia A Medvedeva; Charles Plessy; Morana Vitezic; Jessica Severin; Colin A Semple; Yuri Ishizu; Robert S Young; Margherita Francescatto; Intikhab Alam; Davide Albanese; Gabriel M Altschuler; Takahiro Arakawa; John A C Archer; Peter Arner; Magda Babina; Sarah Rennie; Piotr J Balwierz; Anthony G Beckhouse; Swati Pradhan-Bhatt; Judith A Blake; Antje Blumenthal; Beatrice Bodega; Alessandro Bonetti; James Briggs; Frank Brombacher; A Maxwell Burroughs; Andrea Califano; Carlo V Cannistraci; Daniel Carbajo; Yun Chen; Marco Chierici; Yari Ciani; Hans C Clevers; Emiliano Dalla; Carrie A Davis; Michael Detmar; Alexander D Diehl; Taeko Dohi; Finn Drabløs; Albert S B Edge; Matthias Edinger; Karl Ekwall; Mitsuhiro Endoh; Hideki Enomoto; Michela Fagiolini; Lynsey Fairbairn; Hai Fang; Mary C Farach-Carson; Geoffrey J Faulkner; Alexander V Favorov; Malcolm E Fisher; Martin C Frith; Rie Fujita; Shiro Fukuda; Cesare Furlanello; Masaaki Furino; Jun-ichi Furusawa; Teunis B Geijtenbeek; Andrew P Gibson; Thomas Gingeras; Daniel Goldowitz; Julian Gough; Sven Guhl; Reto Guler; Stefano Gustincich; Thomas J Ha; Masahide Hamaguchi; Mitsuko Hara; Matthias Harbers; Jayson Harshbarger; Akira Hasegawa; Yuki Hasegawa; Takehiro Hashimoto; Meenhard Herlyn; Kelly J Hitchens; Shannan J Ho Sui; Oliver M Hofmann; Ilka Hoof; Furni Hori; Lukasz Huminiecki; Kei Iida; Tomokatsu Ikawa; Boris R Jankovic; Hui Jia; Anagha Joshi; Giuseppe Jurman; Bogumil Kaczkowski; Chieko Kai; Kaoru Kaida; Ai Kaiho; Kazuhiro Kajiyama; Mutsumi Kanamori-Katayama; Artem S Kasianov; Takeya Kasukawa; Shintaro Katayama; Sachi Kato; Shuji Kawaguchi; Hiroshi Kawamoto; Yuki I Kawamura; Tsugumi Kawashima; Judith S Kempfle; Tony J Kenna; Juha Kere; Levon M Khachigian; Toshio Kitamura; S Peter Klinken; Alan J Knox; Miki Kojima; Soichi Kojima; Naoto Kondo; Haruhiko Koseki; Shigeo Koyasu; Sarah Krampitz; Atsutaka Kubosaki; Andrew T Kwon; Jeroen F J Laros; Weonju Lee; Andreas Lennartsson; Kang Li; Berit Lilje; Leonard Lipovich; Alan Mackay-Sim; Ri-ichiroh Manabe; Jessica C Mar; Benoit Marchand; Anthony Mathelier; Niklas Mejhert; Alison Meynert; Yosuke Mizuno; David A de Lima Morais; Hiromasa Morikawa; Mitsuru Morimoto; Kazuyo Moro; Efthymios Motakis; Hozumi Motohashi; Christine L Mummery; Mitsuyoshi Murata; Sayaka Nagao-Sato; Yutaka Nakachi; Fumio Nakahara; Toshiyuki Nakamura; Yukio Nakamura; Kenichi Nakazato; Erik van Nimwegen; Noriko Ninomiya; Hiromi Nishiyori; Shohei Noma; Shohei Noma; Tadasuke Noazaki; Soichi Ogishima; Naganari Ohkura; Hiroko Ohimiya; Hiroshi Ohno; Mitsuhiro Ohshima; Mariko Okada-Hatakeyama; Yasushi Okazaki; Valerio Orlando; Dmitry A Ovchinnikov; Arnab Pain; Robert Passier; Margaret Patrikakis; Helena Persson; Silvano Piazza; James G D Prendergast; Owen J L Rackham; Jordan A Ramilowski; Mamoon Rashid; Timothy Ravasi; Patrizia Rizzu; Marco Roncador; Sugata Roy; Morten B Rye; Eri Saijyo; Antti Sajantila; Akiko Saka; Shimon Sakaguchi; Mizuho Sakai; Hiroki Sato; Suzana Savvi; Alka Saxena; Claudio Schneider; Erik A Schultes; Gundula G Schulze-Tanzil; Anita Schwegmann; Thierry Sengstag; Guojun Sheng; Hisashi Shimoji; Yishai Shimoni; Jay W Shin; Christophe Simon; Daisuke Sugiyama; Takaai Sugiyama; Masanori Suzuki; Naoko Suzuki; Rolf K Swoboda; Peter A C 't Hoen; Michihira Tagami; Naoko Takahashi; Jun Takai; Hiroshi Tanaka; Hideki Tatsukawa; Zuotian Tatum; Mark Thompson; Hiroo Toyodo; Tetsuro Toyoda; Elvind Valen; Marc van de Wetering; Linda M van den Berg; Roberto Verado; Dipti Vijayan; Ilya E Vorontsov; Wyeth W Wasserman; Shoko Watanabe; Christine A Wells; Louise N Winteringham; Ernst Wolvetang; Emily J Wood; Yoko Yamaguchi; Masayuki Yamamoto; Misako Yoneda; Yohei Yonekura; Shigehiro Yoshida; Susan E Zabierowski; Peter G Zhang; Xiaobei Zhao; Silvia Zucchelli; Kim M Summers; Harukazu Suzuki; Carsten O Daub; Jun Kawai; Peter Heutink; Winston Hide; Tom C Freeman; Boris Lenhard; Vladimir B Bajic; Martin S Taylor; Vsevolod J Makeev; Albin Sandelin; David A Hume; Piero Carninci; Yoshihide Hayashizaki

  Nature, 27 Mar. 2014, Peer-reviewed

  
• An atlas of active enhancers across human cell types and tissues

  Robin Andersson; Claudia Gebhard; Irene Miguel-Escalada; Ilka Hoof; Jette Bornholdt; Mette Boyd; Yun Chen; Xiaobei Zhao; Christian Schmidl; Takahiro Suzuki; Evgenia Ntini; Erik Arner; Eivind Valen; Kang Li; Lucia Schwarzfischer; Dagmar Glatz; Johanna Raithel; Berit Lilje; Nicolas Rapin; Frederik Otzen Bagger; Mette Jorgensen; Peter Refsing Andersen; Nicolas Bertin; Owen Rackham; A. Maxwell Burroughs; J. Kenneth Baillie; Yuri Ishizu; Yuri Shimizu; Erina Furuhata; Shiori Maeda; Yutaka Negishi; Christopher J. Mungall; Terrence F. Meehan; Timo Lassmann; Masayoshi Itoh; Hideya Kawaji; Naoto Kondo; Jun Kawai; Andreas Lennartsson; Carsten O. Daub; Peter Heutink; David A. Hume; Torben Heick Jensen; Harukazu Suzuki; Yoshihide Hayashizaki; Ferenc Mueller; Alistair R. R. Forrest; Piero Carninci; Michael Rehli; Albin Sandelin

  NATURE, Mar. 2014, Peer-reviewed

  
• RARGE II: An integrated phenotype database of arabidopsis mutant traits using a controlled vocabulary

  Kenji Akiyama; Atsushi Kurotani; Kei Iida; Takashi Kuromori; Kazuo Shinozaki; Tetsuya Sakurai

  Plant and Cell Physiology, Jan. 2014, Peer-reviewed

  
• Small open reading frames associated with morphogenesis are hidden in plant genomes

  K. Hanada; M. Higuchi-Takeuchi; M. Okamoto; T. Yoshizumi; M. Shimizu; K. Nakaminami; R. Nishi; C. Ohashi; K. Iida; M. Tanaka; Y. Horii; M. Kawashima; K. Matsui; T. Toyoda; K. Shinozaki; M. Seki; M. Matsui

  Proceedings of the National Academy of Sciences, 05 Feb. 2013, Peer-reviewed

  
• Positional correlation analysis improves reconstruction of full-length transcripts and alternative isoforms from noisy array signals or short reads

  Shuji Kawaguchi; Kei Iida; Erimi Harada; Kousuke Hanada; Akihiro Matsui; Masanori Okamoto; Kazuo Shinozaki; Motoaki Seki; Tetsuro Toyoda

  Bioinformatics, Apr. 2012, Peer-reviewed

  
• ARTADE2DB: Improved statistical inferences for arabidopsis gene functions and structure predictions by dynamic structure-based dynamic expression (DSDE) analyses

  Kei Iida; Shuji Kawaguchi; Norio Kobayashi; Yuko Yoshida; Manabu Ishii; Erimi Harada; Kousuke Hanada; Akihiro Matsui; Masanori Okamoto; Junko Ishida; Maho Tanaka; Taeko Morosawa; Motoaki Seki; Tetsuro Toyoda

  Plant and Cell Physiology, Feb. 2011, Peer-reviewed

  
• RAS1, a quantitative trait locus for salt tolerance and ABA sensitivity in Arabidopsis

  Z. Ren; Z. Zheng; V. Chinnusamy; J. Zhu; X. Cui; K. Iida; J.-K. Zhu

  Proceedings of the National Academy of Sciences, 23 Mar. 2010, Peer-reviewed

  
• Posmed-plus: An intelligent search engine that inferentially integrates cross-species information resources for molecular breeding of plants

  Yuko Makita; Norio Kobayashi; Yoshiki Mochizuki; Yuko Yoshida; Satomi Asano; Naohiko Heida; Mrinalini Deshpande; Rinki Bhatia; Akihiro Matsushima; Manabu Ishii; Shuji Kawaguchi; Kei Iida; Kosuke Hanada; Takashi Kuromori; Motoaki Seki; Kazuo Shinozaki; Tetsuro Toyoda

  Plant and Cell Physiology, Jul. 2009, Peer-reviewed

  
• Analysis of multiple occurrences of alternative splicing events in arabidopsis thaliana using novel sequenced full-length cDNAs

  Kei Iida; Kaoru Fukami-Kobayashi; Atsushi Toyoda; Yoshiyuki Sakaki; Masatomo Kobayashi; Motoaki Seki; Kazuo Shinozaki

  DNA Research, Jun. 2009, Peer-reviewed

  
• Bioinformatics analysis suggests base modifications of tRNAs and miRNAs in Arabidopsis thaliana

  Kei Iida; Hailing Jin; Jian-Kang Zhu

  BMC Genomics, 09 Apr. 2009, Peer-reviewed

  
• ROS3 is an RNA-binding protein required for DNA demethylation in Arabidopsis

  Xianwu Zheng; Olga Pontes; Jianhua Zhu; Daisuke Miki; Fei Zhang; Wen-Xue Li; Kei Iida; Avnish Kapoor; Craig S. Pikaard; Jian-Kang Zhu

  Nature, Oct. 2008, Peer-reviewed

  
• The Arabidopsis NFYA5 Transcription Factor Is Regulated Transcriptionally and Posttranscriptionally to Promote Drought Resistance

  Wen-Xue Li; Youko Oono; Jianhua Zhu; Xin-Jian He; Jian-Min Wu; Kei Iida; Xiao-Yan Lu; Xinping Cui; Hailing Jin; Jian-Kang Zhu

  The Plant Cell, Aug. 2008, Peer-reviewed

  
• On the expansion of the pentatricopeptide repeat gene family in plants

  Nicholas O'Toole; Mitsuru Hattori; Charles Andres; Kei Iida; Claire Lurin; Christian Schmitz-Linneweber; Mamoru Sugita; Ian Small

  Molecular Biology and Evolution, Jun. 2008, Peer-reviewed

  
• Alternative splicing at NAGNAG acceptor sites shares common properties in land plants and mammals

  Kei Iida; Masafumi Shionyu; Yasuhiro Suso

  MOLECULAR BIOLOGY AND EVOLUTION, Apr. 2008, Peer-reviewed

  
• Genomic Analysis of Stress Respnse

  Motoaki Seki; Junko Ishida; Maiko Nakajima; Akiko Enju; Kei Iida; Masakazu Satou; Miki Fujita; Yoshihiro Narusaka; Mari Narusaka; Tetsuya Sakurai; Kenji Akiyama; Youko Oono; Ayako Kamei; Taishi Umezawa; Saho Mizukado; Kyonoshin Maruyama; Kazuko Yamaguchi-Shinozaki; Kazuo Shinozaki

  Plant Abiotic Stress, 12 Nov. 2007, Peer-reviewed

  
• Assessing the monophyly of chlorophyll-c containing plastids by multi-gene phylogenies under the unlinked model conditions

  Kei Iida; Kiyotaka Takishita; Kazuhiko Ohshima; Yuji Inagaki

  MOLECULAR PHYLOGENETICS AND EVOLUTION, Oct. 2007, Peer-reviewed

  
• Monitoring expression profiles of Arabidopsis genes during cold acclimation and deacclimation using DNA microarrays.

  Youko Oono; Motoaki Seki; Masakazu Satou; Kei Iida; Kenji Akiyama; Tetsuya Sakurai; Miki Fujita; Kazuko Yamaguchi-Shinozaki; Kazuo Shinozaki

  Functional & integrative genomics, Jul. 2006, Peer-reviewed

  
• Survey of conserved alternative splicing events of mRNAs encoding SR proteins in land plants

  K Iida; M Go

  MOLECULAR BIOLOGY AND EVOLUTION, May 2006, Peer-reviewed

  
• A flexible representation of omic knowledge for thorough analysis of microarray data

  Yoshikazu Hasegawa; Motoaki Seki; Yoshiki Mochizuki; Naohiko Heida; Katsura Hirosawa; Naoki Okamoto; Tetsuya Sakurai; Masakazu Satou; Kenji Akiyama; Kei Iida; Kisik Lee; Shigehiko Kanaya; Taku Demura; Kazuo Shinozaki; Akihiko Konagaya; Tetsuro Toyoda

  PLANT METHODS, 2006, Peer-reviewed

  
• RARTF: Database and tools for complete sets of Arabidopsis transcription factors

  Kei Iida; Motoaki Seki; Tetsuya Sakurai; Masakazu Satou; Kenji Akiyama; Tetsuro Toyoda; Akihiko Konagaya; Kazuo Shinozaki

  DNA RESEARCH, Aug. 2005, Peer-reviewed

  
• RARGE: a large-scale database of RIKEN Arabidopsis resources ranging from transcriptome to phenome

  T Sakurai; M Satou; K Akiyama; K Iida; M Seki; T Kuromori; T Ito; A Konagaya; T Toyoda; K Shinozaki

  NUCLEIC ACIDS RESEARCH, Jan. 2005, Peer-reviewed

  
• Full-length cDNAs for the discovery and annotation of genes in A. thaliana.

  Seki, M; Satou, M; Sakurai, T; Akiyama, K; Iida, K; Ishida, J; Nakajima, M; Enju, A; Narusaka, M; Fujita, M; Oono, Y; Yamaguchi-Shinozaki, K; Carninci, P; Kawai, J; Hayashizaki, Y; Shinozaki, K

  "Plant Functional Genomics (edited by Dario Leister)" Haworth's Food Products Press, Binghamton, New York., 2004, Peer-reviewed

  
• RIKEN Arabidopsis full-length (RAFL) cDNA and its applications for expression profiling under abiotic stress conditions

  M Seki; M Satou; T Sakurai; K Akiyama; K Iida; J Ishida; M Nakajima; A Enju; M Narusaka; M Fujita; Y Oono; A Kamei; K Yamaguchi-Shinozaki; K Shinozaki

  JOURNAL OF EXPERIMENTAL BOTANY, Jan. 2004, Peer-reviewed

  
• Genome-wide analysis of alternative pre-mRNA splicing in Arabidopsis thaliana based on full-length cDNA sequences

  K Iida; M Seki; T Sakurai; M Satou; K Akiyama; T Toyoda; A Konagaya; K Shinozaki

  NUCLEIC ACIDS RESEARCH, 2004, Peer-reviewed

  
• Het-PDB Navi.: A database for protein-small molecule interactions

  A Yamaguchi; K Iida; N Matsui; S Tomoda; K Yura; M Go

  JOURNAL OF BIOCHEMISTRY, Jan. 2004, Peer-reviewed

  
• [Arabidopsis functional genomics using full-length cDNAs].

  Seki M; Shinozaki K; Ishida J; Nakajima M; Enju A; Sakurai T; Satou M; Akiyama K; Iida K; Oono Y

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Nov. 2003, Peer-reviewed

  
• Empirical analysis of transcriptional activity in the Arabidopsis genome

  K Yamada; J Lim; JM Dale; HM Chen; P Shinn; CJ Palm; AM Southwick; HC Wu; C Kim; M Nguyen; P Pham; R Cheuk; G Karlin-Newmann; SX Liu; B Lam; H Sakano; T Wu; GX Yu; M Miranda; HL Quach; M Tripp; CH Chang; JM Lee; M Toriumi; MMH Chan; CC Tang; CS Onodera; JM Deng; K Akiyama; Y Ansari; T Arakawa; J Banh; F Banno; L Bowser; S Brooks; P Carninci; QM Chao; N Choy; A Enju; AD Goldsmith; M Gurjal; NF Hansen; Y Hayashizaki; C Johnson-Hopson; VW Hsuan; K Iida; M Karnes; S Khan; E Koesema; J Ishida; PX Jiang; T Jones; J Kawai; A Kamiya; C Meyers; M Nakajima; M Narusaka; M Seki; T Sakurai; M Satou; R Tamse; M Vaysberg; EK Wallender; C Wong; Y Yamamura; SL Yuan; K Shinozaki; RW Davis; A Theologis; Ecker, JR

  SCIENCE, Oct. 2003, Peer-reviewed

  
• Monitoring expression profiles of Arabidopsis gene expression during rehydration process after dehydration using ca 7000 full-length cDNA microarray.

  Youko Oono; Motoaki Seki; Tokihiko Nanjo; Mari Narusaka; Miki Fujita; Rie Satoh; Masakazu Satou; Tetsuya Sakurai; Junko Ishida; Kenji Akiyama; Kei Iida; Kyonoshin Maruyama; Shinobu Satoh; Kazuko Yamaguchi-Shinozaki; Kazuo Shinozaki

  The Plant journal : for cell and molecular biology, Jun. 2003, Peer-reviewed

  

Misc.

• Author Correction: Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.

  Masahiko Ajiro; Tomonari Awaya; Young Jin Kim; Kei Iida; Masatsugu Denawa; Nobuo Tanaka; Ryo Kurosawa; Shingo Matsushima; Saiko Shibata; Tetsunori Sakamoto; Lorenz Studer; Adrian R Krainer; Masatoshi Hagiwara

  Nature communications, 12 Oct. 2021

  
• DNAメチル化亢進によるPITX1遺伝子発現抑制は食道扁平上皮癌の予後不良と関連する

  河村 由紀; 大坪 武史; 山田 和彦; 萩原 輝記; 大島 健志朗; 飯田 慶; 西方 公郎; 豊田 哲郎; 猪狩 亨; 野原 京子; 服部 正平; 土肥 多惠子

  生命科学系学会合同年次大会, Dec. 2017

  
• Dicer切断反応産物の次世代シークエンス解析を利用した低分子化合物の標的RNA配列モチーフの網羅的探索

  村田亜沙子; 高島裕介; 飯田慶; 須貝亜矢子; 萩原正敏; 中谷和彦

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 食道癌のメチロームおよびトランスクリプトーム統合解析により見出されたホメオボックス遺伝子の発現低下

  河村 由紀; 大坪 武史; 山田 和彦; 萩原 輝記; 大島 健志朗; 飯田 慶; 西方 公郎; 豊田 哲郎; 猪狩 亨; 山田 純; 野原 京子; 服部 正平; 土肥 多惠子

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Monitoring transcriptomic changes in soil-grown roots and shoots of Arabidopsis thaliana subjected to a progressive drought stress

  Khurram Bashir; Sultana Rasheed; Akihiro Matsui; Kei Iida; Maho Tanaka; Motoaki Seki

  Methods in Molecular Biology, 2018, Peer-reviewed

  
• がん細胞の代謝がもたらす組織微小環境を標的にしたがん治療

  豊本 雅靖; 井上 飛鳥; 飯田 慶; 出縄 政嗣; 喜井 勲; 林 佳子; 岸 貴之; 小野木 博; 吉田 優; 細谷 孝充; 青木 淳賢; 萩原 正敏

  生命科学系学会合同年次大会, Dec. 2017

  
• 抗C型肝炎ウイルス能をもつ低分子化合物の同定

  奥野友紀子; NGUYEN Bao Ngoc; NGUYEN Bao Ngoc; 飯田慶; 出縄政嗣; 坂本直哉; 影近弘之; 萩原正敏

  日本ウイルス学会学術集会プログラム・抄録集, 2013

  
• 筋ジストロフィーに対するトランスレーショナル・リサーチ I.エクソン・スキップ ジストロフィンpre-mRNAのスプライシングを変化させる低分子化合物の探索

  萩原正敏; 松尾雅文; 片岡直行; 飯田慶; 西田篤史

  筋ジストロフィーに対するトランスレーショナル・リサーチ 平成22-24年度 総括研究報告書, 2013

  
• 筋ジストロフィーに対するトランスクリプトーム創薬の試み

  飯田慶; 飯田慶; 片岡直行; 西田篤史; 川口修治; 豊田哲郎; 古野正朗; 松尾雅文; 林崎良英; 萩原正敏

  日本RNA学会年会要旨集, 2013

  
• シロイヌナズナ完全長cDNAエンサイクロペディアの作製と遺伝子の機能・発現解析への利用.

  関 原明; 佐藤将一; 石田順子; 櫻井哲也; 中嶋舞子; 秋山顕治; 槐 亜希子; 飯田 慶; 篠崎一雄

  ゲノミクス・プロテオミクスの新展開（今中忠行 監修）. 株式会社 エヌ・ティー・エス., 2004

  
• Arabidopsis Encyclopedia using Full-length cDNAs and its Application for Functional Genomics

  Seki Motoaki; Narusaka Mari; Oono Youko; Fujita Miki; Mizukado Saho; Nanjo Tokihiko; Umezawa Taishi; Kamei Ayako; To Taiko; Yamaguchi-Shinozaki Kazuko; Ecker Joseph R; Ishida Junko; Davis Ronald W; Theologis Athanasios; Carninci Piero; Kawai Jun; Hayashizaki Yoshihide; Sawasaki Tatsuya; Kim Jong-Myong; Hasegawa Yoshinori; Endo Yaeta; Yokoyama Shigeyuki; Satou Masakazu; Shinozaki Kazuo; Sakurai Tetsuya; Nakajima Maiko; Enju Akiko; Kamiya Asako; Akiyama Kenji; Iida Kei

  Plant and Cell Physiology Supplement, 2003

  
• シロイヌナズナ完全長cDNAを用いた植物ゲノムの機能・発現解析.

  関 原明; 佐藤将一; 石田順子; 櫻井哲也; 中嶋舞子; 秋山顕治; 槐 亜希子; 飯田 慶; 大野陽子; 篠崎一雄

  蛋白質 核酸 酵素, 2003

  

Awards

• 20 Dec. 2006

  Short-term Fellow Award (Human Frontier Science Program)

Media Coverage

• RNAスプライシング制御による新規がん免疫療法―ネオ抗原を産生増強する治療薬候補の同定―

  京都大学, Dec. 2022, Internet

  
• RNA結合タンパク質の標的分子探索手法を開発 －複雑なRNA制御のメカニズム解明に期待－

  京都大学, Jul. 2020, Internet

  
• 神経ネットワークの可塑性を支えるRNAの機能に即した化学修飾を明らかにしました

  京都大学, Jul. 2018, Internet

  
• 1細胞RNA分画解読法の開発に成功

  理化学研究所, Jun. 2018, Internet

  
• 神経巨大遺伝子の発現制御メカニズムの発見

  京都大学, May 2018, Internet

  
• 植物の新しい環境ストレス適応機構の発見

  京都大学, Aug. 2017

  
• 次世代シーケンサーのデータ解析精度を向上させる新手法を開発

  理化学研究所, Feb. 2012, Internet

  

External funds: Kakenhi

• Mechanisms for the initial process of hair cell regeneration in avian inner ears

  Grant-in-Aid for Scientific Research (C)

  Basic Section 56050:Otorhinolaryngology-related

  Kyoto University

  中川 隆之

  From 01 Apr. 2020, To 31 Mar. 2023, Granted

  感音難聴;有毛細胞;再生;分化転換;鳥類

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K09708/
• Elucidation of splicing-code with RNA-specialized machine learning system toward overcoming hereditary diseases having splicing misregulations

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48040:Medical biochemistry-related

  Kyoto University

  飯田 慶

  From 01 Apr. 2020, To 31 Mar. 2023, Granted

  RNAスプライシング;遺伝性疾患;バイオインフォマティクス;機械学習;ケミカルバイオロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07310/
• Deciphering neuroepigenetics that regulate the neural differentiation

  Grant-in-Aid for Scientific Research (C)

  Basic Section 46010:Neuroscience-general-related

  Kyoto University

  武内 章英

  From 01 Apr. 2019, To 31 Mar. 2022, Granted

  Sfpq;RNA結合タンパク質;クロマチン・リモデリングファクター;ヒストン修飾;DNA修飾;RNA修飾;超長鎖遺伝子発現制御;免疫沈降・質量分析;長鎖遺伝子発現制御;免疫沈降;質量分析;神経エピジェネティックス;クロマチン制御因子;超長鎖遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06907/
• Widely spread RNA modification at neuronal synapses add functional diversity to local transcriptome

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Dan Ohtan Wang

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  N6-adenosine methvlation;機能分画;シナブトソーム;翻訳制御;精神疾患;発達障害;N6-adenosine methylation;シナプトソーム;地方分権型遺伝子制御;局所翻訳;成長円錐;微小管;epitranscriptomics;local translation;dynamics;epitranscriptome;N6-adenosine;RNA lcoalization;synaptic plasticity;mRNA;chemical modification;methylation;synapse;localization

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H03546/
• Computational studies for molecular mechanism of splicing- modulators upon comparative transcriptome analysis

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Kei IIDA

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  スプライシング;ケミカルバイオロジー;比較ゲノム;比較トランスクリプトーム;筋ジストロフィー;バイオインフォマティクス;個別化医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18459/
• Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Masatoshi Hagiwara

  From 29 May 2015, To 31 Mar. 2020, Project Closed

  遺伝性疾患;スプライシング制御;ポストゲノム創薬;遺伝子性疾患;スプライシング介入ルール;RNA病;トランスクリプトーム解析;モデルトランスクリプトーム解析;RNA病モデル;トランスクリプトーム;kibans

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05721/
• トランスクリプトームの人為的操作による遺伝病の治療

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  萩原 正敏

  From 01 Apr. 2015, To 31 Mar. 2016, Discontinued

  創薬;CRISPR;iPS;スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02505/
• Splicing mechanisms of a novel split intron and evolution of the mRNA maturation process in eukaryotes

  Grant-in-Aid for Scientific Research (A)

  University of Tsukuba

  Tetsuo HASHIMOTO

  From 18 Nov. 2011, To 31 Mar. 2015, Project Closed

  イントロン;トランススプライシング;スプライセオソーム;Giardia;分子進化;スプライソソーム;機能進化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23247038/

Education

Teaching subject(s)

• From Apr. 2014, To Mar. 2015

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2015, To Mar. 2016

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2016, To Mar. 2017

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2017, To Mar. 2018

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2018, To Mar. 2019

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Practicum on Medical Research

  Year-long, 医学研究科