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Yusuke Tarumoto
Institute for Life and Medical Sciences (LiMe) Assistant Professor
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Last Updated :2025/07/01
Basic Information
Affiliated programs (koza)
Faculty
Professional Memberships
Academic Degree
Research History
- From Apr. 2022, To PresentKyoto University, Institute for Life and Medical Sciences, Assistant professor
- From Jul. 2019, To Mar. 2022Kyoto University, Institute for Frontier Life and Medical Sciences, Assistant Professor
- From Apr. 2015, To Jun. 2019Cold Spring Harbor Laboratory, Postdoctoral fellow
- From Apr. 2009, To Apr. 2015Kyoto University, Graduate School of Biostudies, Assistant Professor
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Last Updated :2025/07/01
Research
Research Topics, Overview of the research
Research Topics
Analysis of Gene Regulatory Network in Human Pluripotent Stem CellsOverview of the research
We performed CRISPR screening for the factors essential for pluripotency in human stem cells, and are now investigating how the identified factors regulate gene expression. We also aim to understand the dynamics of the gene regulatory network in human pluripotent stem cells by perturbing gene expression using improved CRISPR-mediated transcriptional regulatory tools.
Research Areas
Papers
- Genome-scale CRISPR-Cas9 screen identifies host factors as potential therapeutic targets for SARS-CoV-2 infection.Madoka Sakai; Yoshie Masuda; Yusuke Tarumoto; Naoyuki Aihara; Yugo Tsunoda; Michiko Iwata; Yumiko Kamiya; Ryo Komorizono; Takeshi Noda; Kosuke Yusa; Keizo Tomonaga; Akiko MakinoiScience, 16 Aug. 2024, Peer-reviewed
- RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations.Masato Ishikawa; Seiichi Sugino; Yoshie Masuda; Yusuke Tarumoto; Yusuke Seto; Nobuko Taniyama; Fumi Wagai; Yuhei Yamauchi; Yasuhiro Kojima; Hisanori Kiryu; Kosuke Yusa; Mototsugu Eiraku; Atsushi MochizukiCommunications biology, 28 Dec. 2023, Peer-reviewed
- Inference of gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbationsMasato Ishikawa; Seiichi Sugino; Yoshie Masuda; Yusuke Tarumoto; Yusuke Seto; Nobuko Taniyama; Fumi Wagai; Yuhei Yamauchi; Yasuhiro Kojima; Hisanori Kiryu; Kosuke Yusa; Mototsugu Eiraku; Atsushi Mochizuki23 Aug. 2023
- Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia.Kazunari Aoki; Mizuki Hyuga; Yusuke Tarumoto; Gohei Nishibuchi; Atsushi Ueda; Yotaro Ochi; Seiichi Sugino; Takashi Mikami; Hirokazu Kobushi; Itaru Kato; Koshi Akahane; Takeshi Inukai; Akifumi Takaori-Kondo; Junko Takita; Seishi Ogawa; Kosuke YusaBlood, 15 Feb. 2024, Peer-reviewed
- Genome-scale CRISPR‒Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infectionMadoka Sakai; Yoshie Masuda; Yusuke Tarumoto; Naoyuki Aihara; Yugo Tsunoda; Michiko Iwata; Yumiko Kamiya; Ryo Komorizono; Takeshi Noda; Kosuke Yusa; Keizo Tomonaga; Akiko Makino07 Mar. 2023
- KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.Yan Zi Au; Muxin Gu; Etienne De Braekeleer; Malgorzata Gozdecka; Demetrios Aspris; Yusuke Tarumoto; Jonathan Cooper; Jason Yu; Swee Hoe Ong; Xi Chen; Konstantinos Tzelepis; Brian J P Huntly; George Vassiliou; Kosuke YusaLeukemia, Apr. 2021, Peer-reviewed
- Convergent organization of aberrant MYB complex controls oncogenic gene expression in acute myeloid leukemia.Sumiko Takao; Lauren Forbes; Masahiro Uni; Shuyuan Cheng; Jose Mario Bello Pineda; Yusuke Tarumoto; Paolo Cifani; Gerard Minuesa; Celine Chen; Michael G Kharas; Robert K Bradley; Christopher R Vakoc; Richard P Koche; Alex KentsiseLife, 02 Feb. 2021, Peer-reviewed
- Salt-inducible kinase inhibition suppresses acute myeloid leukemia progression in vivo.Yusuke Tarumoto; Shan Lin; Jinhua Wang; Joseph P Milazzo; Yali Xu; Bin Lu; Zhaolin Yang; Yiliang Wei; Sofya Polyanskaya; Mark Wunderlich; Nathanael S Gray; Kimberly Stegmaier; Christopher R VakocBlood, 02 Jan. 2020, Peer-reviewed, Lead author
- Tankyrase inhibition sensitizes cells to CDK4 blockade.Miguel Foronda; Yusuke Tarumoto; Emma M Schatoff; Benjamin I Leach; Bianca J Diaz; Jill Zimmerman; Sukanya Goswami; Michael Shusterman; Christopher R Vakoc; Lukas E DowPloS one, Dec. 2019, Peer-reviewed
- Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast.Hiroyuki Irie; Io Yamamoto; Yusuke Tarumoto; Sanki Tashiro; Kurt W Runge; Fuyuki IshikawaPLoS genetics, Aug. 2019, Peer-reviewed
- A Transcription Factor Addiction in Leukemia Imposed by the MLL Promoter Sequence.Bin Lu; Olaf Klingbeil; Yusuke Tarumoto; Tim D D Somerville; Yu-Han Huang; Yiliang Wei; Dorothy C Wai; Jason K K Low; Joseph P Milazzo; Xiaoli S Wu; Zhendong Cao; Xiaomei Yan; Osama E Demerdash; Gang Huang; Joel P Mackay; Justin B Kinney; Junwei Shi; Christopher R VakocCancer cell, 10 Dec. 2018, Peer-reviewed
- LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.Yusuke Tarumoto; Bin Lu; Tim D D Somerville; Yu-Han Huang; Joseph P Milazzo; Xiaoli S Wu; Olaf Klingbeil; Osama El Demerdash; Junwei Shi; Christopher R VakocMolecular cell, 15 Mar. 2018, Peer-reviewed, Lead author
- A TFIID-SAGA Perturbation that Targets MYB and Suppresses Acute Myeloid Leukemia.Yali Xu; Joseph P Milazzo; Tim D D Somerville; Yusuke Tarumoto; Yu-Han Huang; Elizabeth L Ostrander; John E Wilkinson; Grant A Challen; Christopher R VakocCancer cell, 08 Jan. 2018, Peer-reviewed
- Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres.Masahiro Takikawa; Yusuke Tarumoto; Fuyuki IshikawaNucleic acids research, 17 Feb. 2017, Peer-reviewed
- Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast.Yusuke Tarumoto; Junko Kanoh; Fuyuki IshikawaThe Journal of biological chemistry, 28 Jun. 2013, Peer-reviewed, Lead author
- HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast.Moeko Chujo; Yusuke Tarumoto; Koichi Miyatake; Eisuke Nishida; Fuyuki IshikawaThe Journal of biological chemistry, 06 Jul. 2012, Peer-reviewed
- Tel1(ATM) and Rad3(ATR) phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast.Harutake Yamazaki; Yusuke Tarumoto; Fuyuki IshikawaGenes & development, 01 Feb. 2012, Peer-reviewed
Misc.
- 遺伝子制御ネットワークの動態の操作による細胞運命の制御樽本雄介; 杉野成一; 山内悠平; 石川雅人; 瀬戸裕介; 和穎文; 永樂元次; 望月敦史; 遊佐宏介日本分子生物学会年会プログラム・要旨集(Web), 2024
- Inferring gene regulatory networks based on expression dynamics induced by gene perturbations石川雅人; 杉野成一; 増田芳恵; 樽本雄介; 瀬戸裕介; 谷山暢子; 和穎文; 山内悠平; 小嶋泰弘; 木立尚孝; 遊佐宏介; 永樂元次; 望月敦史日本数理生物学会年会(Web), 2024
- CRISPR-KO screen identifies genes that regulate human iPSC differentiation into definitive endoderm平野友章; 杉野成一; 樽本雄介; 遊佐宏介日本ゲノム編集学会大会要旨集, 2024
- Regulation of cell fate by manipulation of dynamics of gene regulatory network樽本雄介; 杉野成一; 山内悠平; 石川雅人; 和穎文; 永樂元次; 望月敦史; 遊佐宏介日本ゲノム編集学会大会要旨集, 2024
- Analysis of dynamics of gene regulatory network using CRISPR-mediated transcriptional pertubation樽本雄介; 杉野成一; 遊佐宏介日本ゲノム編集学会大会要旨集, 2023
- CRISPR-based functional genomics analysis樽本雄介; 遊佐宏介実験医学, Mar. 2024
- Canonical BAF complex is essential for the RUNX1-driven oncogenic program in human T-cell acute lymphoblastic leukemia青木一成; 日向瑞貴; 樽本雄介; 西淵剛平; 越智陽太郎; 越智陽太郎; 杉野成一; 三上貴司; 幸伏寛和; 加藤格; 赤羽弘資; 犬飼岳史; 高折晃史; 滝田順子; 小川誠司; 小川誠司; 小川誠司; 遊佐宏介日本癌学会学術総会抄録集(Web), 2023
- Chemical inhibition of SIK3 as a therapeutic strategy in acute myeloid leukemia.樽本雄介月刊血液内科, Oct. 2020
- Development and improvement of high-throughput CRISPR-Cas9 genetic screening樽本雄介; 遊佐宏介生体の科学, 2020
- 機能的なタンパク質ドメインに対するCRISPRスクリーニングによるがんの治療標的の探索樽本雄介; WANG Jinhua; WANG Jinhua; GRAY Nathanael S; GRAY Nathanael S; SHI Junwei; VAKOC Christopher R日本分子生物学会年会プログラム・要旨集(Web), 2018
- 哺乳類細胞の低容量ストレス応答におけるヒストンシャペロンHIRAの機能解析(Roles of histone chaperone HIRA in low-dose stress responses in mammalian cells)長垣 良和; 中條 萌絵子; 樽本 雄介; 八尾 良司; 石川 冬木日本癌学会総会記事, Sep. 2014
- 分裂酵母Stn1の染色体構造維持における役割滝川雅大; 樽本雄介; 石川冬木日本分子生物学会年会プログラム・要旨集(Web), 2014
- Cellular response to low-dose stressYusuke Tarumoto; Fuyuki IshikawaLeading Author’s, 2014, Peer-reviewed
- 分裂酵母テロメア結合タンパク質による大規模染色体再編の制御(Increased rates of gross chromosomal rearrangements in fission yeast cells defective for telomere-binding proteins)入江 裕之; 樽本 雄介; 石川 冬木日本癌学会総会記事, Oct. 2013
- 分裂酵母Cpc2はストレス応答性MAPキナーゼを介したストレス応答を促進する樽本雄介; 加納純子; 加納純子; 上野敏秀; 間野博行; 間野博行; 石川冬木日本生化学会大会(Web), 2013
- 分裂酵母テロメア結合タンパク質による大規模染色体再編の制御入江裕之; 樽本雄介; 石川冬木日本分子生物学会年会プログラム・要旨集(Web), 2012
- 分裂酵母Cpc2はストレス応答性MAPキナーゼを介したストレス応答を促進する樽本雄介; 加納純子; 加納純子; 上野敏秀; 間野博行; 間野博行; 石川冬木日本分子生物学会年会プログラム・要旨集(Web), 2012
- 分裂酵母におけるチェックポイント活性化延長に対する細胞応答(Cellular responses to prolonged checkpoint activation in fission yeast)二宮 源紀; 三河 拓己; 樽本 雄介; 石川 冬木日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010
- Cpc2/RACK1は環境からのストレスに対する交差耐性に機能する樽本雄介; 加納純子; 加納純子; 石川冬木生化学, 2009
- Cpc2/RACK1は環境からのストレスに対する交差耐性に機能する樽本雄介; 加納純子; 石川冬木日本RNA学会年会要旨集, 2009
- 分裂酵母Cpc2はeIF2αキナーゼによるストレス応答に関与する樽本雄介; 加納純子; 石川冬木生化学, 2007
Presentations
- 遺伝子制御ネットワークの動態の操作による細胞運命の制御樽本雄介; 杉野成一; 山内悠平; 石川雅人; 瀬戸裕介; 和穎文; 永樂元次; 望月敦史; 遊佐宏介日本分子生物学会年会プログラム・要旨集(Web), 2024
- Analysis of transcriptional network in human pluripotent stem cellYusuke TarumotoWorkshop -Stem Cells and Development-, 11 Jul. 2023, Invited
- がん細胞の転写ネットワーク依存性とその制御樽本 雄介京都大学ウイルス・再生医科学研究所 第４回個体の中の細胞社会学セミナー, 23 May 2019
- 機能ドメインを標的としたCRISPRスクリーニングによるがんの新たな治療標的の探索樽本 雄介東京大学医科学研究所 学友会セミナー, 05 Dec. 2018
- 機能ドメインを標的としたCRISPRスクリーニングによるがんの新たな治療標的の探索樽本 雄介金沢大学がん進展制御研究所セミナー, 03 Dec. 2018
- Identification of cancer drug target by functional domain-focused CRISPR screeningYusuke Tarumoto; Jinhua Wang; Nathanael S Gray; Junwei Shi; Christopher R VakocThe 41st Annual Meeting of the Molecular Biology Society of Japan, 28 Nov. 2018
- Targeting transcriptional vulnerability by linked dependency in acute myeloid leukemiaYusuke Tarumoto京都大学 生命科学セミナー, 14 Sep. 2018
- Chemical inhibition of SIK3 as a therapeutic strategy in MEF2C-addicted acute myeloid leukemiaYusuke TarumotoCSHL Mechanisms & Models of Cancer, 15 Aug. 2018
- Cpc2 facilitates stress-activated MAP kinase-mediated stress responseYusuke TarumotoEMBO Conference on Fission Yeast: pombe 2013, 27 Jun. 2013
- Fission yeast Cpc2 facilitates stress-induced transcriptional and translational responsesYusuke TarumotoThe Sixth International Fission Yeast Meeting, 28 Jun. 2011, Invited
External funds: Kakenhi
- Analysis of regulatory mechanisms of stemness in human pluripotent stem cellsGrant-in-Aid for Scientific Research (C)Basic Section 44020:Developmental biology-relatedKyoto University樽本 雄介From 01 Apr. 2022, To 31 Mar. 2025, Grantedヒト多能性幹細胞;遺伝子制御ネットワーク;CRISPR;遺伝子発現制御;未分化性;多能性幹細胞;遺伝子発現;CRISPRスクリーニング
- Transcriptional corepressor-mediated regulation of pluripotency in stem cellsGrant-in-Aid for Early-Career ScientistsBasic Section 43010:Molecular biology-relatedKyoto UniversityYusuke TarumotoFrom 01 Apr. 2020, To 31 Mar. 2022, Project Closed多能性幹細胞;未分化性;遺伝子発現;転写抑制補因子;スクリーニング;CRISPR;CRISPRスクリーニング;転写因子
- Regulation of chromatin structure and gene expression in cross-tolerance to environmental stressGrant-in-Aid for Young Scientists (B)Kyoto UniversityYusuke TARUMOTOFrom 01 Apr. 2013, To 31 Mar. 2015, Project Closedストレス応答;シグナル伝達;遺伝子発現制御;クロマチン;分子生物学
- Formation of facultative heterochromatin in fission yeastGrant-in-Aid for Challenging Exploratory ResearchKyoto UniversityFuyuki ISHIKAWAFrom 01 Apr. 2011, To 31 Mar. 2013, Project Closed遺伝学;ゲノム;発現制御;発生・分化;エピジェネティックス
- Telomere Functions in Cancer DevelopmentGrant-in-Aid for Scientific Research (S)Kyoto UniversityFuyuki ISHIKAWAFrom 01 Apr. 2010, To 31 Mar. 2016, Project Closedゲノム不安定性;テロメア;皮膚発がん;次世代シーケンサー;グアニン4重鎖構造;CST複合体;塩基除去修復
- 独自レポーター技術を用いた姉妹染色分体融合制御因子の探索Grant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 43:Biology at molecular to cellular levels, and related fieldsKyoto University林 眞理From 30 Jun. 2023, To 31 Mar. 2025, Grantedテロメア;姉妹染色分体融合;染色体不安定化;細胞老化;がん化;スクリーニング;染色体融合;老化;がん
External funds: others
- 遺伝子制御ネットワークの動態操作による細胞の分化制御Takeda Science Foundation, 2024年度医学系研究助成（基礎）From 01 Apr. 2024, To 31 Mar. 2026
- CRISPRによる転写制御系を用いた多能性幹細胞の遺伝子発現制御ネットワークの解析Mochida Memorial Foundation for Medical and Pharmaceutical Research, Research Grant
- 多能性幹細胞の未分化性を維持する新規転写調節因子の同定と機能解析Takeda Science Foundation, Research GrantFrom 01 Apr. 2020, To 31 Mar. 2022
- 転写抑制補因子による多能性幹細胞の未分化性維持機構の解析Kato Memorial Bioscience Foundation, Research GrantFrom 01 Apr. 2020, To 31 Mar. 2023
- Targeting Linked Dependency Between Kinase and Transcription FactorLauri Strauss Leukemia Foundation GrantFrom 2018, To 2018樽本雄介
- Identification of Genetic Dependencies and Therapeutic Targets in AMLLauri Strauss Leukemia Foundation GrantFrom 2016, To 2017樽本雄介
- Investigation of mechanism of epigenetic inhibitor-induced therapeutic activityLauri Strauss Leukemia Foundation GrantFrom 2015, To 2016樽本雄介
- 低容量ストレス応答の分子機構の解析京都大学若手研究者スタートアップ研究費From 2009, To 2010樽本雄介
