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Matsuura, Kenkyo
Institute for Life and Medical Sciences (LiMe) Assistant Professor
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Last Updated :2025/06/20
Basic Information
Affiliated programs (koza)
- Graduate School of Medicine, 医科学専攻 がん・幹細胞シグナル, 助教
- Graduate School of Medicine, 医学専攻 がん・幹細胞シグナル, 助教
- Graduate School of Pharmaceutical Sciences, 薬科学専攻 がん・幹細胞シグナル学, 助教
Professional Memberships
Academic Degree
- M.S. in Pharmaceutical Sciences(Kanazawa University)
- Ph.D. in Pharmaceutical Sciences(Kanazawa University)
Academic Resume (Graduate Schools)
- Kanazawa University, Division of Pharmaceutical Chemistry and Biology, 修了
- Kanazawa University, Division of Life Sciences, 修了
Academic Resume (Undergraduate School/Majors)
High School
High School
Kanazawa Nisui High School
Language of Instruction
ID,URL
ORCID ID
J-Global ID
Researcher number
50836096
Website(s) (URL(s))
researchmap URL
list
Last Updated :2025/06/20
Research
Research Topics, Overview of the research
Research Topics
Breast cancer and leukemia cancer stem cell regulation by cellular metabolismOverview of the research
We found that the expression patterns of some metabolic enzymes are distinct among the subtypes, and the suppression of the enzyme results in attenuation of cancer cell growth. We hypothesize that certain types of cancer exhibit dependency on the metabolic pathway for progression. By utilizing metabolism biosensor, we analyze the dynamics of the metabolic pathway and cancer malignancy mechanism. This study will help to understand the biology of cancer metabolism and develop a new therapeutic strategy.
Research Areas
Papers
- The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia.Kei Kozawa; Miho Sekai; Kenji Ohba; Shoko Ito; Hiroaki Sako; Takeshi Maruyama; Mai Kakeno; Takanobu Shirai; Keisuke Kuromiya; Tomoko Kamasaki; Koki Kohashi; Shinya Tanaka; Susumu Ishikawa; Nanami Sato; Shota Asano; Hironori Suzuki; Nobuyuki Tanimura; Yohei Mukai; Noriko Gotoh; Mishie Tanino; Shinya Tanaka; Ken Natsuga; Tomoyoshi Soga; Tomonori Nakamura; Yukihiro Yabuta; Mitinori Saitou; Takahiro Ito; Kenkyo Matsuura; Makoto Tsunoda; Toyone Kikumori; Tadashi Iida; Yasuyuki Mizutani; Yuki Miyai; Kozo Kaibuchi; Atsushi Enomoto; Yasuyuki FujitaCurrent biology : CB, 26 Jul. 2021, Peer-reviewed
- Spironolactone‐induced XPB degradation depends on CDK7 kinase and SCF FBXL18 E3 ligaseUeda M; Matsuura K; Kawai H; Wakasugi M; Matsunaga TGenes to Cells, Apr. 2019, Peer-reviewed
- Dimer‐specific immunoprecipitation of active caspase‐2 identifies TRAF proteins as novel activatorsRobeson AC; Lindblom KR; Wojton J; Kornbluth S; Matsuura KThe EMBO Journal, Jul. 2018, Peer-reviewed, Last author, Corresponding author
- Activation of disulfide bond cleavage triggered by hydrophobization and lipophilization of functionalized dihydroasparagusic acidFuyuhiko Inagaki; Miyuki Momose; Naoya Maruyama; Kenkyo Matsuura; Tsukasa Matsunaga; Chisato MukaiOrganic and Biomolecular Chemistry, 2018, Peer-reviewed
- Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatinK. Matsuura; N-J Huang; K. Cocce; L. Zhang; S. KornbluthONCOGENE, Mar. 2017, Peer-reviewed, Lead author
- Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell deathC-S Yang; K. Matsuura; N-J Huang; A. C. Robeson; B. Huang; L. Zhang; S. KornbluthONCOGENE, Jun. 2015, Peer-reviewed, Lead author
- A Network of Substrates of the E3 Ubiquitin Ligases MDM2 and HUWE1 Control Apoptosis Independently of p53Manabu Kurokawa; Jiyeon Kim; Joseph Geradts; Kenkyo Matsuura; Liu Liu; Xu Ran; Wenle Xia; Thomas J. Ribar; Ricardo Henao; Mark W. Dewhirst; Wun-Jae Kim; Joseph E. Lucas; Shaomeng Wang; Neil L. Spector; Sally KornbluthSCIENCE SIGNALING, May 2013, Peer-reviewed
- Rsk-mediated phosphorylation and 14-3-3 epsilon binding of Apaf-1 suppresses cytochrome c-induced apoptosisJiyeon Kim; Amanda B. Parrish; Manabu Kurokawa; Kenkyo Matsuura; Christopher D. Freel; Joshua L. Andersen; Carrie E. Johnson; Sally KornbluthEMBO JOURNAL, Mar. 2012, Peer-reviewed
- Cleavage-mediated activation of Chk1 during apoptosisKenkyo Matsuura; Mitsuo Wakasugi; Katsumi Yamashita; Tsukasa MatsunagaJOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2008, Peer-reviewed, Lead author
- DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cellsMitsuo Wakasugi; Kenkyo Matsuura; Atsushi Nagasawa; DongTao Fu; Hiroko Shimizu; Ken-ichi Yamamoto; Shunichi Takeda; Tsukasa MatsunagaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2007, Peer-reviewed, Lead author
Misc.
- Cancer stem cell regulation by histone acylationKenkyo MatsuuraIgaku no ayumi, May 2020, Invited, Lead author
- Ubiquitin ligase UBR5 regulates chemotherapeutic resistance in cancerKenkyo Matsuura; Sally KornbluthSeikagaku, Jun. 2018, Invited, Lead author
- Metabolic Regulation of Apoptosis in CancerK. Matsuura; K. Canfield; W. Feng; M. KurokawaINTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 327, 2016, Invited, Lead author
Presentations
- 分岐鎖アミノ酸代謝依存的な乳がん悪性化制御機構についての解析松浦顕教; 黒田逸月; 篠永りりこ; 山本瑞生; 井上純一郎; 今村博臣; 服部鮎奈; 伊藤貴浩第10回 がんと代謝研究会 in 別府, 02 Aug. 2024
- Activated branched-chain amino acid metabolism regulates the aggressive nature in human triple negative breast cancerMatsuura K; Kondo K; Kuroda I; Nakano T; Shinonaga R; Yamamoto M; Inoue J; Imamura H; Hattori A; Ito T82nd JCA, 21 Sep. 2023
- Branched-chain amino acid metabolism regulates triple negative breast cancer growth by BCAT1 upregulationKenkyo Matsuura; Itsuki Kuroda; Takato Nakano; Mizuki Yamamoto; Jun-ichiro Inoue; John Glushka; Arthur S. Edison; Hiromi Imamura; Ayuna Hattori; Takahiro Ito第45回日本分子生物学会年会, 02 Dec. 2022
- Triple negative breast cancer regulation by branched-chain amino acidsKenkyo Matsuura; Takato Nakano; Itsuki Kuroda; Mizuki Yamamoto; Jun-ichiro Inoue; John Glushka; Arthur S. Edison; Hiromi Imamura; Ayuna Hattori; Takahiro Ito第8回 がんと代謝研究会 in 佐渡, 20 Jul. 2022
- Regulation of Programmed Cell Death by Protein UbiquitylationKenkyo MatsuuraRSセミナー 岡山大学大学院医歯薬学総合研究科, 07 Apr. 2021, Invited
- Dimer-specific immunoprecipitation of active caspase-2 by BiFC/GFP-Trap system identifies TRAF proteins as novel activatorsKenkyo Matsuura; Alexander C Robeson; Kelly R Lindblom; Jeffrey Wojton; Sally KornbluthMBSJ2018, Nov. 2018
- UBR5 ubiquitin ligase downregulates proapoptotic protein MOAP-1 and contributes to cisplatin resistance in ovarian cancerKenkyo Matsuura; Nai-Jia Huang; Kimberly Cocce; Liguo Zhang; Sally KornbluthBMB2015, Dec. 2015
- Fatty Acid Synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell deathKenkyo Matsuura; Chih-Sheng Yang; Nai-Jia Huang; Alexander C Robeson; Bofu Huang; Liguo Zhang; Sally KornbluthMBSJ2014, Nov. 2014
- Apoptosis induced by fatty acid synthase inhibition is mediated by caspase-2 and its upstream activator REDD1Kenkyo Matsuura; Chih-Sheng Yang; Nai-Jia Huang; Alexander C Robeson; Liguo Zhang; Sally KornbluthGordon Research Conference; Cell Death, 2014
- Mechanistic Studies of Apoptosis Induced by Fatty Acid Synthase Inhibition Identifies a Novel Caspase-2 ActivatorKenkyo Matsuura18th Women's Cancer Research Forum at Duke University, 2013
- Apoptosis induced by fatty acid synthase inhibition is mediated by caspase-2 and its upstream activator REDD1Kenkyo Matsuura; Chih-Sheng Yang; Nai-Jia Huang; Alexander C Robeson; Liguo Zhang; Kelly R Lindblom; Sally KornbluthCold Spring Harbor Laboratory Meeting; Cell Death, 2013
- Regulation of apoptosis by glucose-induced phosphorylation of caspase-2 isoformsKenkyo Matsuura; Chih-Sheng Yang; Marisa R Buchakjian; Sally KornbluthGordon Research Conferences; Cell Death, 2012
- The role of caspase-dependent Chk1 cleavage during apoptosisKenkyo Matsuura; Mitsuo Wakasugi; Manabu Inobe; Katsumi Yamashita; Tsukasa MatsunagaThe Keystone Symposia Telomere Biology and DNA Repair, 2009
- アポトーシスにおけるChk1の切断と活性化Kenkyo Matsuura; Mitsuo Wakasugi; Katsuni Yamashita; Manabu Inobe; Tsukasa MatsunagaBMB2008, 2008
- Caspase-Dependent Cleavage of Chk1 during ApoptosisKenkyo Matsuura; Mitsuo Wakasugi; Tsukasa MatsunagaAtaxia-Telangiectasia Workshop 2008, 2008
- Caspase-dependent cleavage and activation of Chk1 during apoptosisKenkyo Matsuura; Mitsuo Wakasugi; Manabu Inobe; Katsumi Yamashita; Tsukasa Matsunaga6th 3R Symposium, 2008
- DT40細胞におけるDNA損傷ストレスに伴うChk1の切断と分解Kenkyo Matsuura; Mitsuo Wakasugi; Tsukasa MatsunagaBMB2007, 2007
- ニワトリDT40コンディショナルノックアウト細胞を用いたDDB1の機能解析Kenkyo Matsuura; Mitsuo Wakasugi; DongTao Fu; Tsukasa Matsunaga日本薬学会北陸支部平成18年度第1回総会及び第114回例会, 2006
- DDB1 is essential for cell proliferation in vertebrate cellsKenkyo Matsuura; DongTao Fu; Mitsuo Wakasugi; Tsukasa Matsunaga20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, 2006
External funds: Kakenhi
- Live imaging and selective isolation of protein post-translational modification with bimolecular fluorescence complementationGrant-in-Aid for Scientific Research (C)Basic Section 37010:Bio-related chemistryKyoto UniversityKenkyo MatsuuraFrom 01 Apr. 2019, To 31 Mar. 2022, Project ClosedBiFC;GFP nanobody;複合体精製;タンパク質翻訳後修飾;ユビキチン
- Chemical approaches to understand the complex mechanism of nucleotide excision repairGrant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedKanazawa UniversityTsukasa MATSUNAGAFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closedヌクレオチド除去修復;ケミカルバイオロジー;阻害剤;タンパク質分解誘導剤;近位依存性ビオチン標識法;低分子化合物;DNA損傷プローブ
- 細胞内アミノ酸ダイナミクスのリアルタイム可視化によるがん幹細胞維持シグナルの解明Grant-in-Aid for Scientific Research (C)Basic Section 50010:Tumor biology-relatedKyoto University松浦 顕教From 01 Apr. 2022, To 31 Mar. 2025, Grantedアミノ酸;代謝;がん幹細胞;FRETバイオセンサー
list
Last Updated :2025/06/20
Education
Teaching subject(s)
- From 01 Apr. 2025, To 31 Mar. 2026Research Proposal Writing Practice B8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2025, To 31 Mar. 2026Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2025, To 31 Mar. 2026Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2025, To 31 Mar. 2026Medicinal Frontier Science Research C8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2025, To 31 Mar. 2026Medicinal Frontier Science Research B8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2025, To 31 Mar. 2026Medicinal Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2025, To 31 Mar. 2026Pharmaceutical Laboratory IV : Biochemistry and MicrobiologyC906, Fall, Faculty of Pharmaceutical Sciences, 3
- From 01 Apr. 2025, To 31 Mar. 2026Seminar on Critical Reading of Scientific Papers B8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2024, To 31 Mar. 2025Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2024, To 31 Mar. 2025Research Proposal Writing Practice B8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2024, To 31 Mar. 2025Medicinal Frontier Science Research B8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2024, To 31 Mar. 2025Medicinal Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2024, To 31 Mar. 2025Medicinal Frontier Science Research C8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2024, To 31 Mar. 2025Pharmaceutical Laboratory IV : Biochemistry and MicrobiologyC906, Fall, Faculty of Pharmaceutical Sciences, 3
- From 01 Apr. 2024, To 31 Mar. 2025Seminar on Critical Reading of Scientific Papers B8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Research Proposal Writing Practice B8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2023, To 31 Mar. 2024Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2023, To 31 Mar. 2024Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2023, To 31 Mar. 2024Pharmaceutical Laboratory IV : Biochemistry and MicrobiologyC906, Fall, Faculty of Pharmaceutical Sciences, 3
- From 01 Apr. 2023, To 31 Mar. 2024Medicinal Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2023, To 31 Mar. 2024Medicinal Frontier Science Research B8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2023, To 31 Mar. 2024Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyA906, Fall, Faculty of Pharmaceutical Sciences, 4
- From 01 Apr. 2023, To 31 Mar. 2024Seminar on Critical Reading of Scientific Papers B8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2022, To 31 Mar. 2023Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2022, To 31 Mar. 2023Pharmaceutical Laboratory IV : Biochemistry and MicrobiologyC906, Fall, Faculty of Pharmaceutical Sciences, 3
- From 01 Apr. 2022, To 31 Mar. 2023Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2022, To 31 Mar. 2023Pharmaceutical Laboratory 4 : Biochemistry and MicrobiologyA906, Fall, Faculty of Pharmaceutical Sciences, 4
- From 01 Apr. 2022, To 31 Mar. 2023Medical Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2022, To 31 Mar. 2023Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
