Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 幹細胞遺伝学, 助教
• Graduate School of Medicine, 医科学専攻 幹細胞遺伝学, 助教

Professional Memberships

• 日本内科学会
• Japanese society of myeloma
• Japanese society for transplantation and cellular therapy
• Japanese Society of Hematology
• Japanese Cancer Association

Academic Degree

• 博士（医学）(京都大学)

Research History

• From Apr. 2020, To Present

  京都大学医生物学研究所, 幹細胞遺伝学 (遊佐宏介教授), 助教
• From Apr. 2017, To Mar. 2020

  大阪大学大学院生命機能研究科, 幹細胞・免疫発生 (長澤丘司教授), 研究生
• From Apr. 2013, To Mar. 2017

  京都大学大学院医学研究科, 血液内科学 (高折晃史教授), 博士課程大学院生
• From Apr. 2010, To Mar. 2013

  神戸市立医療センター中央市民病院, 血液内科専攻医
• From Apr. 2008, To Mar. 2010

  京都大学医学部附属病院, 初期臨床研修医
• From Apr. 2002, To Mar. 2008

  京都大学医学部医学科

Profile

• Profile

  血液内科医としてのバックグランド (血液内科専門医・指導医、総合内科専門医) を生かし、がん生物学の研究を行っています。京都大学大学院医学研究科血液内科学講座 (高折晃史教授)、大阪大学大学院生命機能研究科幹細胞・免疫発生研究室 (長澤丘司教授) を経て、現在は京都大学医生物学研究所幹細胞遺伝学分野 (遊佐宏介教授) で、主として以下のテーマに取り組んでいます。

  
  

  (1) がん細胞におけるSWI/SNF複合体の機能解析

  
  

  SWI/SNF複合体はクロマチンリモデリング複合体の1つで、ATPの加水分解によって得られるエネルギーを使ってヌクレオソームをスライド或いは除去することで、オープンクロマチン領域を形成し、転写因子などのゲノムDNAへの結合を可能にしています。一部のがんではSWI/SNF複合体構成要素をコードする遺伝子に機能喪失型変異を認める一方、別の一部のがんではSWI/SNF複合体はがん転写ネットワークの維持に必須です。我々は様々ながん種をモデルに、ATAC-seq、RNA-seq、CRISPR-Cas9技術などを駆使してSWI/SNF複合体の機能解析を行っています。

  
  

  　Aoki et al., Blood 2024; Ueda et al., ongoing project

  
  

  (2) がん細胞における転写制御因子同士の機能的連関

  
  

  転写制御因子は互いに協調しながら、遺伝子の発現を制御し、がんの増殖を維持しています。CRISPRスクリーニングなどを使って、がん細胞における転写制御因子同士の新たな機能的連関を明らかにします。

  
  

  　Hyuga et al., ongoing project; Aoki et al., ongoing project

  
  

  (3) がん細胞とがん微小環境と相互作用

  
  

  生体内においてがん細胞は、特別な微小環境いわゆる「がん微小環境」によって維持されています。我々は、in situ hybridization技術、遺伝子改変マウス、CRISPRスクリーニングなどを用いて、がん微小環境によるがん細胞増殖維持機構の詳細を明らかにします。

  
  

  　Aoki et al., Br J Haematol 2021; Aoki et al., Blood 2024; Aoki et al., in preparation; Ueda et al., ongoing project; Itatani et al., ongoing project

ID,URL

• J-Global ID

  202001019615238871

researchmap URL

• https://researchmap.jp/aoki.kazunari.4c

Research

Research Topics, Overview of the research

• Research Topics

  The maintenance of hematopoietic stem cells and blood cancer stem cells in bone marrow microenvironment

Research Areas

• Life sciences, Tumor biology, 転写制御
• Life sciences, Hematology and oncology, 造血器腫瘍
• Life sciences, Genetics, CRISPR-Cas9システム

Papers

• 

  Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia.

  Kazunari Aoki; Mizuki Hyuga; Yusuke Tarumoto; Gohei Nishibuchi; Atsushi Ueda; Yotaro Ochi; Seiichi Sugino; Takashi Mikami; Hirokazu Kobushi; Itaru Kato; Koshi Akahane; Takeshi Inukai; Akifumi Takaori-Kondo; Junko Takita; Seishi Ogawa; Kosuke Yusa

  Blood, 15 Feb. 2024, Peer-reviewed, Lead author, Corresponding author

  
• Single-unit unrelated cord blood transplantation versus HLA-matched sibling transplantation in adults with advanced myelodysplastic syndrome: A registry-based study from the adult MDS working group of the Japanese society for transplantation and cellular therapy.

  Takaaki Konuma; Hidehiro Itonaga; Yoshimitsu Shimomura; Machiko Fujioka; Kazunari Aoki; Naoyuki Uchida; Makoto Onizuka; Atsushi Jinguji; Masatsugu Tanaka; Yasunori Ueda; Yuta Katayama; Masashi Sawa; Haruyuki Tanaka; Hirohisa Nakamae; Toshiro Kawakita; Yumiko Maruyama; Satoshi Takahashi; Fumihiko Ishimaru; Junya Kanda; Tatsuo Ichinohe; Yoshiko Atsuta

  Hematological oncology, 18 Aug. 2023, Peer-reviewed

  
• Allogeneic transplantation of bone marrow versus peripheral blood stem cells from HLA-identical relatives in patients with myelodysplastic syndromes and oligoblastic acute myeloid leukemia: a propensity score analysis of a nationwide database.

  Hidehiro Itonaga; Yasushi Miyazaki; Kazunari Aoki; Naoki Shingai; Yukiyasu Ozawa; Takahiro Fukuda; Keisuke Kataoka; Toshiro Kawakita; Yasunori Ueda; Takahide Ara; Masatsugu Tanaka; Yuta Katayama; Masashi Sawa; Tetsuya Eto; Junya Kanda; Yoshiko Atsuta; Ken Ishiyama

  Annals of hematology, 15 Mar. 2023, Peer-reviewed

  
• Significance of Omitting Day 11 Mini-Dose Methotrexate for GVHD Prophylaxis After Unrelated Bone Marrow Transplantation

  Naokazu Nakamura; Fumiya Wada; Tadakazu Kondo; Kazunari Aoki; Yasuyuki Arai; Chisaki Mizumoto; Junya Kanda; Toshio Kitawaki; Kouhei Yamashita; Akifumi Takaori-Kondo

  Transplantation and Cellular Therapy, Nov. 2022, Peer-reviewed

  
• 

  Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

  Yoshiki Omatsu; Shota Aiba; Tomonori Maeta; Kei Higaki; Kazunari Aoki; Hitomi Watanabe; Gen Kondoh; Riko Nishimura; Shu Takeda; Ung-il Chung; Takashi Nagasawa

  Nature Communications, Dec. 2022, Peer-reviewed

  
• 

  Identification of CXCL12-abundant reticular cells in human adult bone marrow.

  Kazunari Aoki; Masako Kurashige; Michiko Ichii; Kei Higaki; Tatsuki Sugiyama; Takashi Kaito; Wataru Ando; Nobuhiko Sugano; Takashi Sakai; Hirohiko Shibayama; Akifumi Takaori-Kondo; Eiichi Morii; Yuzuru Kanakura; Takashi Nagasawa

  British journal of haematology, May 2021, Peer-reviewed, Lead author

  
• Increased opportunity for prolonged survival after allogeneic hematopoietic stem cell transplantation in patients aged 60-69 years with myelodysplastic syndrome.

  Hidehiro Itonaga; Ken Ishiyama; Kazunari Aoki; Jun Aoki; Takayuki Ishikawa; Naoyuki Uchida; Kazuteru Ohashi; Yasunori Ueda; Takahiro Fukuda; Toru Sakura; Yuju Ohno; Koji Iwato; Hirokazu Okumura; Tadakazu Kondo; Tatsuo Ichinohe; Minoko Takanashi; Yoshiko Atsuta; Yasushi Miyazaki

  Annals of hematology, Jun. 2019, Peer-reviewed

  
• Clinical impact of the loss of chromosome 7q on outcomes of patients with myelodysplastic syndromes treated with allogeneic hematopoietic stem cell transplantation.

  Hidehiro Itonaga; Ken Ishiyama; Kazunari Aoki; Jun Aoki; Takayuki Ishikawa; Kazuteru Ohashi; Takayuki Fukuda; Yukiyasu Ozawa; Shuichi Ota; Naoyuki Uchida; Tetsuya Eto; Koji Iwato; Yuju Ohno; Minoko Takanashi; Tatsuo Ichinohe; Yoshiko Atsuta; Yasushi Miyazaki

  Bone marrow transplantation, Sep. 2019, Peer-reviewed

  
• Prognostic Impact of Donor Source on Allogeneic Hematopoietic Stem Cell Transplantation Outcomes in Adults with Chronic Myelomonocytic Leukemia: A Nationwide Retrospective Analysis in Japan.

  Hidehiro Itonaga; Kazunari Aoki; Jun Aoki; Takayuki Ishikawa; Ken Ishiyama; Naoyuki Uchida; Toru Sakura; Kazuteru Ohashi; Mineo Kurokawa; Yukiyasu Ozawa; Ken-Ichi Matsuoka; Yukinori Nakamura; Fumihiko Kimura; Koji Iwato; Yuichiro Nawa; Makoto Hirokawa; Koji Kato; Tatsuo Ichinohe; Yoshiko Atsuta; Yasushi Miyazaki

  Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Apr. 2018, Peer-reviewed

  
• Outcome differences between children and adolescents and young adults with non-Hodgkin lymphoma following stem cell transplantation.

  Ryoji Kobayashi; Tetsuo Mitsui; Naoto Fujita; Tomoo Osumi; Tomohiro Aoki; Kazunari Aoki; Ritsuro Suzuki; Takahiro Fukuda; Toshihiro Miyamoto; Koji Kato; Hirohisa Nakamae; Hiroaki Goto; Tetsuya Eto; Masami Inoue; Takehiko Mori; Kiminori Terui; Masahito Onizuka; Katsuyoshi Koh; Yuhki Koga; Tatsuo Ichinohe; Akihisa Sawada; Yoshiko Atsuta; Junji Suzumiya

  International journal of hematology, Mar. 2017, Peer-reviewed

  
• Outcome of allogeneic hematopoietic stem cell transplantation in cases of mature T/NK-cell neoplasms: a single-center retrospective analysis.

  Hiroyuki Yamazaki; Kazunari Aoki; Tadakazu Kondo; Momoko Nishikori; Toshiyuki Kitano; Masakatsu Hishizawa; Kouhei Yamashita; Akifumi Takaori-Kondo

  Annals of hematology, Feb. 2017, Peer-reviewed

  
• Impacts of graft-versus-host disease on outcomes after allogeneic hematopoietic stem cell transplantation for chronic myelomonocytic leukemia: A nationwide retrospective study.

  Hidehiro Itonaga; Masako Iwanaga; Kazunari Aoki; Jun Aoki; Ken Ishiyama; Takayuki Ishikawa; Toru Sakura; Takahiro Fukuda; Yuho Najima; Toshiaki Yujiri; Takehiko Mori; Mineo Kurokawa; Yuichiro Nawa; Naoyuki Uchida; Yoshihisa Morishita; Hisako Hashimoto; Tetsuya Eto; Makoto Hirokawa; Yasuo Morishima; Tokiko Nagamura-Inoue; Yoshiko Atsuta; Yasushi Miyazaki

  Leukemia research, Feb. 2016, Peer-reviewed

  
• Clinical significance of high-dose cytarabine added to cyclophosphamide/total-body irradiation in bone marrow or peripheral blood stem cell transplantation for myeloid malignancy.

  Yasuyuki Arai; Kazunari Aoki; June Takeda; Tadakazu Kondo; Tetsuya Eto; Shuichi Ota; Hisako Hashimoto; Takahiro Fukuda; Yukiyasu Ozawa; Yoshinobu Kanda; Chiaki Kato; Mineo Kurokawa; Koji Iwato; Makoto Onizuka; Tatsuo Ichinohe; Yoshiko Atsuta; Akiyoshi Takami

  Journal of hematology & oncology, 04 Sep. 2015, Peer-reviewed

  Access this paper :

  
• CXCR4/CXCL12 signaling impacts enamel progenitor cell proliferation and motility in the dental stem cell niche.

  Tamaki Yokohama-Tamaki; Keishi Otsu; Hidemitsu Harada; Shunichi Shibata; Nobuko Obara; Kazuharu Irie; Akiyoshi Taniguchi; Takashi Nagasawa; Kazunari Aoki; Steven R Caliari; Daniel W Weisgerber; Brendan A C Harley

  Cell and tissue research, Dec. 2015, Peer-reviewed

  
• Efficiency of high-dose cytarabine added to CY/TBI in cord blood transplantation for myeloid malignancy.

  Yasuyuki Arai; June Takeda; Kazunari Aoki; Tadakazu Kondo; Satoshi Takahashi; Yasushi Onishi; Yukiyasu Ozawa; Nobuyuki Aotsuka; Yasuji Kouzai; Hirohisa Nakamae; Shuichi Ota; Chiaki Nakaseko; Hiroki Yamaguchi; Koji Kato; Yoshiko Atsuta; Akiyoshi Takami

  Blood, 16 Jul. 2015, Peer-reviewed

  
• 

  Allogeneic haematopoietic cell transplantation with reduced-intensity conditioning for elderly patients with advanced myelodysplastic syndromes: a nationwide study.

  Kazunari Aoki; Takayuki Ishikawa; Ken Ishiyama; Jun Aoki; Hidehiro Itonaga; Takahiro Fukuda; Kazuhiko Kakihana; Naoyuki Uchida; Yasunori Ueda; Tetsuya Eto; Takehiko Mori; Tadakazu Kondo; Koji Iwato; Yasuo Morishima; Junji Tanaka; Yoshiko Atsuta; Yasushi Miyazaki

  British journal of haematology, Feb. 2015, Peer-reviewed, Lead author, Corresponding author

  
• Serum IgA level, monocyte count, and international prognostic index are independently associated with overall survival in patients with HTLV-I-negative nodal peripheral T cell lymphoma.

  Aiko Kato; Yukihiro Imai; Kazunari Aoki; Sumie Tabata; Akiko Matsushita; Hisako Hashimoto; Takayuki Takahashi; Takayuki Ishikawa

  Annals of hematology, Jul. 2014, Peer-reviewed

  
• Successful treatment of high-risk acute promyelocytic leukemia in very elderly patients using all-trans retinoic acid plus reduced-dose idarubicin.

  Takao Fujisawa; June Takeda; Kazunari Aoki; Takayuki Ishikawa

  Annals of hematology, Sep. 2014, Peer-reviewed, Corresponding author

  
• The prognostic impact of absolute lymphocyte and monocyte counts at diagnosis of diffuse large B-cell lymphoma in the rituximab era.

  Kazunari Aoki; Sumie Tabata; Noboru Yonetani; Akiko Matsushita; Takayuki Ishikawa

  Acta haematologica, 11 Jul. 2013, Peer-reviewed, Lead author, Corresponding author

  
• Therapeutic effects of lenalidomide on hemorrhagic intestinal myeloma-associated AL amyloidosis.

  Seiji Nagano; Minako Mori; Aiko Kato; Yuichiro Ono; Kazunari Aoki; Hiroshi Arima; Yoko Takiuchi; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Takayuki Ishikawa; Hiroyuki Imai; Takayuki Takahashi

  Internal medicine (Tokyo, Japan), 15 May 2013, Peer-reviewed

  
• Efficacy and tolerability of reduced-dose 21-day cycle rituximab and cyclophosphamide, doxorubicin, vincristine and prednisolone therapy for elderly patients with diffuse large B-cell lymphoma.

  Kazunari Aoki; Takayuki Takahashi; Sumie Tabata; Masayuki Kurata; Akiko Matsushita; Kenichi Nagai; Takayuki Ishikawa

  Leukemia & lymphoma, Nov. 2013, Peer-reviewed, Lead author

  
• Successful treatment of anti-erythropoietin antibody-mediated pure red cell aplasia with low-dose prednisolone.

  Kazunari Aoki; Yuichiro Ono; Sumie Tabata; Akiko Matsushita; Takayuki Ishikawa

  International journal of hematology, Feb. 2013, Peer-reviewed, Lead author, Corresponding author

  
• [Fatal hepatic failure due to AL amyloidosis in a patient with multiple myeloma].

  Sumie Tabata; Masayuki Kurata; June Takeda; Yuuki Funayama; Nobuhiko Yamauchi; Kazunari Aoki; Aiko Kato; Yuichirou Ono; Hiroshi Arima; Yoko Takiuchi; Seiji Nagano; Akiko Matsushita; Yukihiro Imai; Takayuki Ishikawa; Takayuki Takahashi

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 01 Nov. 2012, Peer-reviewed

  
• Central nervous system involvement of primary cutaneous diffuse large B cell lymphoma-leg type diagnosed according to the WHO 2008 classification.

  Kazunari Aoki; Hiroshi Arima; Sumie Tabata; Akiko Matsushita; Takayuki Ishikawa; Takayuki Takahashi

  Annals of hematology, Dec. 2012, Peer-reviewed, Lead author, Corresponding author

  
• Human herpes virus 6-associated myelitis following allogeneic bone marrow transplantation.

  Kazunari Aoki; Hiroshi Arima; Aiko Kato; Hisako Hashimoto; Sumie Tabata; Akiko Matsushita; Takayuki Ishikawa

  Annals of hematology, Oct. 2012, Peer-reviewed, Lead author

  
• Leukemic manifestation of blastic plasmacytoid dendritic cell neoplasm lacking skin lesion : a borderline case between acute monocytic leukemia.

  Yoko Takiuchi; Hayato Maruoka; Kazunari Aoki; Aiko Kato; Yuichiro Ono; Seiji Nagano; Hiroshi Arima; Daichi Inoue; Minako Mori; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Mari Nishio; Yukihiro Imai; Yukihiro Imai; Kiminari Ito; Haruyuki Fujita; Norimitsu Kadowaki; Takayuki Ishikawa; Takayuki Takahashi

  Journal of clinical and experimental hematopathology : JCEH, 01 Jan. 2012, Peer-reviewed

  
• Blastic Plasmacytoid Dendritic Cell Neoplasm Expressing the CD13 Myeloid Antigen

  Daichi Inoue; Kyoko Maruyama; Kazunari Aoki; Seiji Nagano; Hayato Maruoka; Yukihiro Imai; Kiminari Ito; Takayuki Ishikawa; Takayuki Takahashi

  Acta Haematologica, 24 Jun. 2011, Peer-reviewed

  
• Enteropathy-associated T-cell lymphoma type II complicated by autoimmune hemolytic anemia.

  Aiko Kato; Yoko Takiuchi; Kazunari Aoki; Yuichiro Ono; Hiroshi Arima; Seiji Nagano; Sumie Tabata; Soshi Yanagita; Akiko Matsushita; Hayato Maruoka; Masaya Wada; Yukihiro Imai; Takayuki Ishikawa; Takayuki Takahashi

  Journal of clinical and experimental hematopathology : JCEH, 01 Jan. 2011, Peer-reviewed

  
• Systemic follicular lymphoma with massive intestinal involvement with leukemic manifestation.

  Yuichiro Ono; Kazunari Aoki; Aiko Kato; Hiroshi Arima; Yohko Takiuchi; Seiji Nagano; Sumie Tabata; Sohshi Yanagita; Akiko Matsushita; Hayato Maruoka; Yukihiro Imai; Takayuki Ishikawa; Takayuki Takahashi

  Journal of clinical and experimental hematopathology : JCEH, 01 Jan. 2011, Peer-reviewed

  
• Acute renal failure associated with systemic polyoma BK virus activation in a patient with peripheral T-cell lymphoma.

  Kazunari Aoki; Shinichi Kotani; Tatsuo Ichinohe; Tadakazu Kondo; Takayuki Ishikawa

  International journal of hematology, Nov. 2010, Peer-reviewed, Lead author

  

Misc.

• IMPACT OF AZACITIDINE PRETREATMENT ON OUTCOMES OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION IN PATIENTS WITH HIGH-RISK MYELODYSPLASTIC SYNDROME

  J. Aoki; T. Konuma; K. Aoki; K. Iwato; Y. Ozawa; Y. Kanda; K. Ohashi; N. Uchida; H. Kobayashi; M. Sawa; T. Fukuda; M. Takanashi; Y. Atsuta; K. Ishiyama

  HAEMATOLOGICA, Jun. 2017

  
• ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR PATIENTS AGED 60 YEARS OR OLDER WITH MYELODYSPLASTIC SYNDROME IN JAPAN

  H. Itonaga; K. Ishiyama; J. Aoki; K. Aoki; T. Ishikawa; N. Uchida; K. Ohashi; Y. Ueda; T. Fukuda; T. Ichinohe; M. Takanashi; Y. Atsuta; Y. Miyazaki

  LEUKEMIA RESEARCH, Apr. 2017

  
• Risk Stratification of DLBCL Patients According to NCCN-IPI in Our Hospital

  Yasuhiro Kazuma; Kazunari Aoki; Yotaro Ochi; Yusuke Koba; Yoshimitsu Shimomura; Yosuke Nagahata; Nobuhiko Yamauchi; Yuichiro Ono; Nobuhiro Hiramoto; Sumie Tabata; Noboru Yonetani; Akiko Matsushita; Hisako Hashimoto; Takayuki Ishikawa

  BLOOD, Dec. 2014

  
• Impact of Unbalanced Translocation Der(1;7)(q10;p10) and-7/Del(7q) on the Prognostic Value after Allogeneic Hematopoietic Stem Cell Transplantation in Myelodysplastic Syndromes: A Nationwide Retrospective Study

  Hidehiro Itonaga; Kazunari Aoki; Jun Aoki; Ken Ishiyama; Takayuki Ishikawa; Kazuteru Ohashi; Takahiro Fukuda; Yukiyasu Ozawa; Naoki Kobayashi; Naoyuki Uchida; Tetsuya Eto; Minoko Takanashi; Tatsuo Ichinohe; Yoshiko Atsuta; Yasushi Miyazaki

  BLOOD, Dec. 2015

  
• IMPACT OF GRAFT-VERSUS-HOST DISEASE ON OUTCOME OF ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR LOW-RISK MYELODYSPLASTIC SYNDROMES

  J. Aoki; K. Ishiyama; K. Aoki; T. Ishikawa; H. Itonaga; T. Fukuda; K. Ohashi; K. Iwato; K. Chiaki; T. Mori; K. Miyamura; T. Nagamura; S. Mori; T. Ichinohe; Y. Atsuta; Y. Miyazaki

  HAEMATOLOGICA, Jun. 2014

  
• Reduced-Intensity Conditioning of Allogeneic Transplantation for Nodal Peripheral T-Cell Lymphomas

  Kazunari Aoki; Ritsuro Suzuki; Dai Chihara; Tatsuya Suzuki; Sung-Won Kim; Takahiro Fukuda; Naoyuki Uchida; Mitsuru Tsudo; Ken-ichi Matsuoka; Hiroatsu Ago; Tokiko Nagamura-Inoue; Yasuo Morishima; Hisashi Sakamaki; Yoshiko Atsuta; Junji Suzumiya

  BLOOD, Dec. 2014

  
• Clinical Impact of Complex Karyotype, Monosomal Karyotype and Acquisition of Chromosomal Abnormalities in Patients with Myelodysplastic Syndromes

  June Takeda; Hiroshi Kawabata; Kazunari Aoki; Shuichi Shiga; Masahiro Kawahara; Toshio Kitawaki; Masakatsu Hishizawa; Tadakazu Kondo; Toshiyuki Kitano; Noboru Yonetani; Sumie Tabata; Nobuhiro Hiramoto; Akiko Matsushita; Hisako Hashimoto; Takayuki Ishikawa; Norimitsu Kadowaki; Akifumi Takaori-Kondo

  BLOOD, Dec. 2014

  
• Impact of azacitidine pretreatment on outcomes of allo-HSCT in patients with high-risk MDS

  青木淳; 青木一成; 小沼貴晶; 土岐典子; 片山雄太; 内田直之; 澤正史; 鬼塚真仁; 松岡賢市; 神田善伸; 神田善伸; 小澤幸泰; 福田隆浩; 木村貴文; 熱田由子; 石山謙

  日本造血細胞移植学会総会プログラム・抄録集, 2020

  
• 60歳以上の骨髄異形成症候群症例に対する同種造血幹細胞移植の成績

  糸永英弘; 石山謙; 青木淳; 青木一成; 石川隆之; 内田直之; 大橋一輝; 上田恭典; 福田隆浩; 一戸辰夫; 高梨美乃子; 熱田由子; 宮崎泰司

  日本造血細胞移植学会総会プログラム・抄録集, 2017

  
• 周期的な血球減少を経て発症したETP-ALLの1例

  長畑 洋佑; 青木 一成; 平本 展大; 田端 淑恵; 石川 隆之

  臨床血液, Nov. 2014

  
• びまん性大細胞型B細胞リンパ腫における節外病変が予後に与える影響(The prognostic impacts of extra-nodal involvements in diffuse large B-cell lymphoma in the Rituximab era)

  青木 一成

  神戸市立病院紀要, Mar. 2014

  
• びまん性大細胞型B細胞リンパ腫における末梢血リンパ球数および単球数が予後に与える影響(The prognostic impact of absolute lymphocyte and monocyte counts at diagnosis of diffuse large B-cell lymphoma in the rituximab era)

  青木 一成

  神戸市立病院紀要, Mar. 2014

  
• Azacitidine Improves Survival in Myelodysplastic Syndromes; Single Institute Retrospective Study

  June Takeda; Nobuhiko Yamauchi; Kazunari Aoki; Yuichiro Ono; Yuki Funayama; Yasuhiro Kazuma; Yosuke Nagahata; Yotaro Ochi; Yusuke Koba; Sumie Tabata; Nobuhiro Hiramoto; Akiko Matsushita; Noboru Yonetani; Hisako Hashimoto; Takayuki Ishikawa

  BLOOD, Nov. 2013

  
• Influence Of Acute and Chronic Graft-Versus-Host Disease On Outcome After Allogeneic Hematopoietic Stem Cell Transplantation For Chronic Myelomonocytic Leukemia

  Hidehiro Itonaga; Masako Iwanaga; Kazunari Aoki; Jun Aoki; Ken Ishiyama; Takeshi Kobayashi; Toru Sakura; Takahiro Fukuda; Toshiaki Yujiri; Makoto Hirokawa; Yasuo Morishima; Tokiko Nagamura-Inoue; Yoshiko Atsuta; Takayuki Ishikawa; Yasushi Miyazaki

  BLOOD, Nov. 2013

  
• 化学療法中に脳転移しHAART療法のみで縮小を認めたHIV関連NK/T細胞性リンパ腫の1例

  長畑 洋佑; 加藤 愛子; 米谷 昇; 数馬 安浩; 竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 小野 祐一郎; 田端 淑恵; 松下 章子; 今井 幸弘; 石川 隆之

  日本リンパ網内系学会会誌, Apr. 2013

  
• 高齢者びまん性大細胞型B細胞リンパ腫の治療成績と予後因子の検討

  青木 一成

  神戸市立病院紀要, Mar. 2013

  
• 高齢の骨髄異形成症候群患者における単一臍帯血移植の予後は不良である

  青木一成; 石山謙; 糸永英弘; 福田隆浩; 谷口修一; 上田恭典; 土岐典子; 杉尾康浩; 森島泰雄; 長村登紀子; 田中淳司; 熱田由子; 石川隆之; 宮崎泰司

  日本造血細胞移植学会総会プログラム・抄録集, 2013

  
• Prognostic Impact of Serum Soluble Interleukin-2 Receptor Values Just After Completion of R-CHOP in Diffuse Large B-Cell Lymphoma

  Nobuhiko Yamauchi; Kazunari Aoki; June Takeda; Yuki Funayama; Aiko Kato; Yuichiro Ono; Sumie Tabata; Akiko Matsushita; Noboru Yonetani; Takayuki Ishikawa

  BLOOD, Nov. 2012

  
• 肝アミロイドーシスによる肝不全で死亡した多発性骨髄腫

  田端 淑恵; 倉田 雅之; 竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 加藤 愛子; 小野 祐一郎; 有馬 浩史; 瀧内 曜子; 永野 誠治; 松下 章子; 今井 幸弘; 石川 隆之; 高橋 隆幸

  臨床血液, Nov. 2012

  
• AMLにおけるCD200発現の意義の検討

  竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 加藤 愛子; 小野 祐一郎; 田端 淑恵; 松下 章子; 石川 隆之

  臨床血液, Sep. 2012

  
• 高リスクMDSに対するAzacitidineの治療効果

  田端 淑恵; 竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 加藤 愛子; 小野 祐一郎; 有馬 浩史; 瀧内 曜子; 永野 誠治; 松下 章子; 石川 隆之

  臨床血液, Sep. 2012

  
• Coombs試験陰性Evans症候群

  南出 竜典; 青木 一成; 田端 淑恵; 松下 章子; 石川 隆之

  臨床血液, Aug. 2012

  
• 低用量プレドニゾロンで寛解に至った抗エリスロポイエチン抗体陽性慢性赤芽球ろう

  青木 一成; 小野 祐一郎; 田端 淑恵; 松下 章子; 石川 隆之

  臨床血液, Aug. 2012

  
• Triple Hit lymphomaの1例

  竹田 淳恵; 永野 誠治; 小野 祐一郎; 船山 由樹; 山内 寛彦; 青木 一成; 加藤 愛子; 田端 淑恵; 松下 章子; 石川 隆之; 丸岡 隼人

  日本リンパ網内系学会会誌, May 2012

  
• 6カラーフローサイトメトリーによる造血器腫瘍のイムノフェノタイピング

  丸岡 隼人; 江藤 正明; 那須 浩二; 老田 達雄; 岸本 健治; 宇佐美 郁哉; 青木 一成; 小野 祐一郎; 加藤 愛子; 有馬 浩史; 瀧内 曜子; 永野 誠治; 田端 淑恵; 柳田 宗之; 松下 章子; 高橋 隆幸; 石川 隆之

  神戸市立病院紀要, Mar. 2012

  
• 閉塞性肺炎を契機に診断された気管支病変主体のNK/T細胞リンパ腫の1例

  松本 健; 大塚 今日子; 永田 一真; 青木 一成; 富井 啓介; 今井 幸弘

  日本呼吸器学会誌, Feb. 2012

  
• Double Ph cloneが確認されたCMLに対しダサチニブを使用した1例

  永野 誠治; 竹田 淳恵; 船山 由樹; 山内 寛彦; 青木 一成; 小野 祐一郎; 加藤 愛子; 有馬 浩史; 瀧内 曜子; 田端 淑恵; 松下 章子; 石川 隆之

  臨床血液, Jan. 2012

  
• 大顆粒リンパ球性白血病に合併した赤芽球癆によるヘモクロマトーシスに行った鉄キレート療法

  永野 誠治; 青木 一成; 小野 祐一郎; 加藤 愛子; 有馬 浩史; 瀧内 曜子; 田端 淑恵; 柳田 宗之; 松下 章子; 石川 隆之

  臨床血液, Aug. 2011

  
• 同種移植後に脳炎症状を呈さず発症したSIADHにおいて髄液中のHHV6再活性化が原因と考えられた1例

  青木 一成; 瀧内 曜子; 柳田 宗之; 石川 隆之; 橋本 尚子

  臨床血液, Aug. 2011

  
• PCI施行後に気腫性胆嚢炎をきたした1例

  多田 朋弥; 青木 一成; 静田 聡; 塩井 哲雄; 尾野 亘; 木村 剛; 北 徹

  Circulation Journal, Apr. 2009

  

Presentations

• 血液がんにおけるSWI/SNF複合体の機能

  Hematology Expert Conference, 20 Feb. 2025, Invited

  
• 古典的BAF複合体はT細胞性急性リンパ性白血病のがん転写プログラムを制御する

  Advanced Hematology Seminar 2024, 31 Aug. 2024, Invited

  
• cBAF 複合体は T 細胞性急性リンパ性白血病のがん転写プログラムを制御する

  第19回血液学若手研究者勉強会（麒麟塾）, 29 Jun. 2024, Invited

  
• Canonical BAF complex is essential for the RUNX1-driven oncogenic program in human T-cell acute lymphoblastic leukemia

  第82回日本癌学会学術総会, 21 Sep. 2023

  

Books and Other Publications

• 血液内科

  Contributor, T-ALLの微小環境との相互作用と増殖のメカニズム

  科学評論社, Aug. 2024

  
• 臨床画像

  Contributor, クロマチンリモデリングと腫瘍-基礎編-

  MEDICAL VIEW, Jul. 2024

  
• がんゲノムペディア

  Contributor, CRISPRスクリーニング

  羊土社, Feb. 2024

  

Awards

• 29 May 2021

  Japanese Society of Myeloma, Japanese Society of Myeloma Research Award
• 10 Oct. 2020

  Japanese Society of Hematology, 82nd Annual Meeting of the Japanese Society of Hematology Best Poster Award
• Nov. 2015

  日本白血病研究基金, 日本白血病研究基金臨床医学特別賞
• Oct. 2015

  Japanese Society of Hematology, 日本血液学会奨励賞
• Dec. 2012

  American Society of Hematology, American Society of Hematology Abstract Achievement Award

External funds: Kakenhi

• CXCL12-CXCR4軸による造血幹細胞制御に必須の細胞内分子の網羅的探索

  Grant-in-Aid for Scientific Research (C)

  Basic Section 54010:Hematology and medical oncology-related

  Kyoto University

  青木 一成

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  CXCL12;CXCR4;CRISPR;造血幹細胞;ニッシェ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08393/
• in vivo CRISPRスクリーニングの技術確立と生体内細胞増殖機構の解析

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  遊佐 宏介

  From 05 Apr. 2021, To 31 Mar. 2025, Granted

  CRISPR-Cas9;遺伝学的スクリーニング;白血病;in vivoモデル;Genetic screening;Leukemia;in vivo model;ゲノム編集;Flp;スクリーニング;T-ALL;in vivo CRISPRスクリーニング;多発性骨髄腫;増殖必須因子;分子標的;Cre

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04959/

Administration

Faculty management (title, position)

• From 01 Apr. 2023

  共同利用機器等委員会　委員

Academic, Social Contribution

Committee Memberships

• From Oct. 2024, To Present

  評議員, 日本血液学会
• From Apr. 2024, To Mar. 2025

  教員会議運営委員, 京都大学医生物学研究所
• From Oct. 2021, To Present

  医の倫理委員会委員, 京都大学医生物学研究所