Basic Information

Faculty

• 薬学部

Professional Memberships

• 分子生物学会
• 日本薬理学会
• 日本生化学会
• The Molecular Biology Society of Japan
• The Japanese Pharmacological Society
• The Japanese Biochemical Society

Academic Degree

• 理学修士(東京大学)
• 博士（医学）(山梨医科大学)

Academic Resume (Graduate Schools)

• 東京大学, 大学院理学系研究科生物化学専攻修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 理学部生物化学科, 卒業

Research History

• From Apr. 2007, To Present

  京都大学大学院薬学研究科, 薬理ゲノミクス分野, 准教授
• From Jul. 2002, To Mar. 2007

  京都大学大学院薬学研究科, ゲノム創薬科学分野, 助教授
• From Mar. 2002, To Jun. 2004

  国立成育医療センター研究所, 薬剤治療研究部, 研究室長
• From 1997

  国立小児病院小児医療センター小児薬理部研究員
• From 1996

  科学技術庁長期在学研究員併任 米国Affymax
• From 1993

  国立小児病院小児医療センター小児薬理部研究員
• From 1992

  山梨医科大学薬理学教室助手
• From 1989

  味の素株式会社中央研究所研究員

Language of Instruction

• English
• Japanese

ID,URL

• J-Global ID

  200901078357152310

researchmap URL

• https://researchmap.jp/read0166268

Research

Research Topics, Overview of the research

• Research Topics

  adrenergic receptor, Green Fluorescent Protein, Microarray, high-throuput screening, receptor internalization, protein,fatty acid receptor,orphan receptor

• Overview of the research

  G蛋白質共役受容体を主たる研究対象として、個体レベルでの薬理評価から、分子生物学、バイオインフォマティクス、ハイスループットシステムまでを含む広い手法で研究を行ってきた。
  最近では、オーファン受容体のリガンド探索により、新規脂肪酸受容体GPR120を発見、肥満・糖尿病等への関与を明らかにしており、この分子を標的とする創薬研究を進めたいと考えている。

Research Interests

• GPR120
• Fatty acid receptor
• タンパク間相互作用
• 受容体インターナリゼーション
• ハイスループットスクリーニング
• マイクロアレイ
• 緑色蛍光蛋白
• アドレナリン受容体
• protein
• receptor internalization
• high-throuput screening
• Microarray
• Green Fluorescent Protein
• adrenergic receptor

Research Areas

• Life sciences, Pharmacology

Papers

• Inhibition of GPR120 signaling in intestine ameliorates insulin resistance and fatty liver under high-fat diet feeding.

  Takuma Yasuda; Norio Harada; Tomonobu Hatoko; Atsuhiko Ichimura; Eri Ikeguchi-Ogura; Yuki Murata; Naoki Wada; Sakura Kiyobayashi; Shunsuke Yamane; Akira Hirasawa; Nobuya Inagaki

  American journal of physiology. Endocrinology and metabolism, 01 May 2023

  
• わが国における非アルコール性脂肪性肝疾患(NAFLD)の現状と将来展望 臨床・基礎研究から薬物治療及び薬剤師活動へのフィードバック NAFLD/NASH発症におけるn-3系多価不飽和脂肪酸の関与と将来展望

  中本 賀寿夫; 小畑 友紀雄; 平澤 明; 金 啓二; 金 守良; 徳山 尚吾

  薬学雑誌, Apr. 2016

  
• Receptor tyrosine kinase activation induces free fatty acid 4 receptor phosphorylation, β-arrestin interaction, and internalization

  Sócrates Villegas-Comonfort; Alejandro Guzmán-Silva; M. Teresa Romero-Ávila; Yoshinori Takei; Gozoh Tsujimoto; Akira Hirasawa; J. Adolfo García-Sáinz

  European Journal of Pharmacology, 15 Jul. 2019

  
• Binding mode prediction of a CK2 inhibitor, Hematein by the MM/PBSA method

  Nagamatsu Kazuhiko; Nakamura Shinya; Kinoshita Takayoshi; Hirasawa Akira; Tsujimoto Gozoh; Nakanishi Isao

  Symposium on Chemical Information and Computer Sciences, 2011

  
• Visualization of Intracellular Signal with GFP fused Proteins

  太田 善浩; 宮脇 敦史; 廣瀬 謙造; 北村 大介; 中西 守; 河田 光博; 平澤 明; 淡路 健雄; 辻本 豪三

  Seibutsu Butsuri, 1999

  
• 2SE06 可視化生物学手法によるG蛋白質共役型受容体の細胞内動態の解析 (GFP融合蛋白を用いた細胞内信号の可視化)

  平澤 明; 淡路 健雄; 辻本 豪三

  生物物理, 1999

  
• DHA-GPR40/FFAR1シグナルの破綻がストレス誘導性慢性疼痛を誘導する

  相澤 風花; 中本 賀寿夫; 平澤 明; 栗原 崇; 宮田 篤郎; 徳山 尚吾

  日本薬学会年会要旨集, Mar. 2019

  
• 長鎖脂肪酸受容体GPR40/FFAR1の欠損は、情動行動異常を示す

  中本 賀寿夫; 大垣 圭弘; 相澤 風花; 山下 琢矢; 平澤 明; 栗原 崇; 宮田 篤郎; 徳山 尚吾

  日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2017

  
• 疼痛時における脳内遊離脂肪酸の変化

  中本 賀寿夫; 相澤 風花; 山下 琢矢; 平澤 明; 栗原 崇; 宮田 篤郎; 糟谷 史代; 徳山 尚吾

  PAIN RESEARCH, Jun. 2017

  
• GPR40/FFAR1欠損が情動機能に及ぼす影響

  相澤 風花; 中本 賀寿夫; 平澤 明; 栗原 崇; 宮田 篤朗; 徳山 尚吾

  日本神経精神薬理学雑誌, Jun. 2017

  
• 長鎖脂肪酸受容体GPR40/FFAR1の欠損は痛みを増強する

  中本 賀寿夫; 相澤 風花; 山下 琢矢; 万倉 三正; 小山 豊; 糟谷 史代; 平澤 明; 栗原 崇; 宮田 篤郎; 徳山 尚吾

  日本神経精神薬理学雑誌, Jun. 2017

  
• Transcriptome analysis revealed bisphenol A and nonylphenol affect reproduction.

  Tomoaki Tanaka; Yuriko Ono; Naoki Hikihara; Ayana Yoshida; Hasumi Yamada; Shogo Higaki; Tomomi Nishie; Ikuo Tooyama; Keiko Iida; Akira Hirasawa; Tatsuyuki Takada

  Reproductive toxicology (Elmsford, N.Y.), Sep. 2019

  
• Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory.

  Yoshinori Takei; Yoko Amagase; Keiko Iida; Tomohiro Sagawa; Ai Goto; Ryuichi Kambayashi; Hiroko Izumi-Nakaseko; Akio Matsumoto; Shinichi Kawai; Atsushi Sugiyama; Tatsuyuki Takada; Akira Hirasawa

  GeroScience, 20 May 2022

  
• A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus.

  Kensuke Iwasa; Shinji Yamamoto; Kota Yamashina; Nan Yagishita-Kyo; Kei Maruyama; Takeo Awaji; Yoshinori Takei; Akira Hirasawa; Keisuke Yoshikawa

  Journal of neuroinflammation, 27 Dec. 2021

  
• Medium-chain triglycerides inhibit long-chain triglyceride-induced GIP secretion through GPR120-dependent inhibition of CCK

  Yuki Murata; Norio Harada; Shigenobu Kishino; Kanako Iwasaki; Eri Ikeguchi-Ogura; Shunsuke Yamane; Tomoko Kato; Yoshinori Kanemaru; Akiko Sankoda; Tomonobu Hatoko; Sakura Kiyobayashi; Jun Ogawa; Akira Hirasawa; Nobuya Inagaki

  iScience, Sep. 2021, Peer-reviewed

  
• In vivo emergence of beige-like fat in chickens as physiological adaptation to cold environments

  Rina Sotome; Akira Hirasawa; Motoi Kikusato; Taku Amo; Kyohei Furukawa; Anna Kuriyagawa; Kouichi Watanabe; Anne Collin; Hitoshi Shirakawa; Ryota Hirakawa; Yuta Tanitaka; Hideki Takahashi; Guoyao Wu; Tomonori Nochi; Tsuyoshi Shimmura; Craig H. Warden; Masaaki Toyomizu

  Amino Acids, Mar. 2021, Peer-reviewed

  
• FFAR1/GPR40 Contributes to the Regulation of Striatal Monoamine Releases and Facilitation of Cocaine-Induced Locomotor Activity in Mice.

  Yuko Sadamura; Shanta Thapa; Ryota Mizunuma; Yuki Kambe; Akira Hirasawa; Kazuo Nakamoto; Shogo Tokuyama; Koji Yoshimoto; Kazunori Arita; Atsuro Miyata; Tatsuki Oyoshi; Takashi Kurihara

  Frontiers in pharmacology, 2021, Peer-reviewed

  
• Molecular Mechanism of Apoptosis by Amyloid β-Protein Fibrils Formed on Neuronal Cells

  Eri Takada; Kaori Okubo; Yoshiaki Yano; Keiko Iida; Masataka Someda; Akira Hirasawa; Shin Yonehara; Katsumi Matsuzaki

  ACS Chemical Neuroscience, 04 Mar. 2020, Peer-reviewed

  
• Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176

  Tianyu Wang; Shumpei Nakagawa; Takahito Miyake; Genzui Setsu; Sumihiro Kunisue; Kaoru Goto; Akira Hirasawa; Hitoshi Okamura; Yoshiaki Yamaguchi; Masao Doi

  Scientific Reports, Mar. 2020, Peer-reviewed

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• Structural insights for producing CK2α1-specific inhibitors.

  Masato Tsuyuguchi; Tetsuko Nakaniwa; Akira Hirasawa; Isao Nakanishi; Takayoshi Kinoshita

  Bioorganic & medicinal chemistry letters, 15 Jan. 2020, Peer-reviewed

  
• Stimulation of insulin secretion by acetylenic fatty acids in insulinoma MIN6 cells through FFAR1

  Nishino, Katsutoshi; Uesugi, Haruka; Hirasawa, Akira; Ohtera, Anna; Miyamae, Yusaku; Neffati, Mohamed; Isoda, Hiroko; Kambe, Taiho; Masuda, Seiji; Irie, Kazuhiro; Nagao, Masaya

  Biochemical and biophysical research communications, 15 Nov. 2019, Peer-reviewed

  
• Free fatty acid receptors, G protein-coupled receptor 120 and G protein-coupled receptor 40, are essential for oil-induced gastric inhibitory polypeptide secretion.

  Akiko Sankoda; Norio Harada; Tomoko Kato; Eri Ikeguchi; Kanako Iwasaki; Shunsuke Yamane; Yuki Murata; Akira Hirasawa; Nobuya Inagaki

  Journal of diabetes investigation, Nov. 2019, Peer-reviewed

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• 中鎖脂肪酸トリグリセリドは長鎖脂肪酸トリグリセリド摂取時のGIP分泌を抑制し肥満を軽減する

  村田 由貴; 原田 範雄; 岸野 重信; 山根 俊介; 岩崎 可南子; 加藤 朋子; 池口 絵理; 金丸 良徳; 波床 朋信; 許 櫻華; 小川 順; 平澤 明; 稲垣 暢也

  肥満研究, Oct. 2019

  
• Free fatty acid receptor GPR120 and GPR40 are essential for oil-induced GIP secretion.

  Sankoda A; Harada N; Kato T; Iwasaki K; Yamane S; Ikeguchi E; Murata Y; Hirasawa A; Inagaki N

  J Diabetes Investig., 2019, Peer-reviewed

  
• Complex formation between the vasopressin 1b receptor, β-arrestin-2, and the μ-opioid receptor underlies morphine tolerance.

  Taka-Aki Koshimizu; Kenji Honda; Sachi Nagaoka-Uozumi; Atsuhiko Ichimura; Ikuo Kimura; Michio Nakaya; Nobuya Sakai; Katsushi Shibata; Kentarou Ushijima; Akio Fujimura; Akira Hirasawa; Hitoshi Kurose; Gozoh Tsujimoto; Akito Tanoue; Yukio Takano

  Nature neuroscience, Jun. 2018, Peer-reviewed

  
• 長鎖脂肪酸受容体GPR120とGPR40は脂肪摂取後GIP分泌に必須である

  三小田 亜希子; 原田 範雄; 山根 俊介; 池口 絵里; 平澤 明; 稲垣 暢也

  糖尿病, Apr. 2018

  
• DHA supplementation prevent the progression of NASH via GPR120 signaling

  Kazuo Nakamoto; Koki Shimada; Shinichi Harada; Yasuko Morimoto; Akira Hirasawa; Shogo Tokuyama

  European Journal of Pharmacology, 05 Feb. 2018, Peer-reviewed

  
• The Deletion of GPR40/FFAR1 Signaling Damages Maternal Care and Emotional Function in Female Mice

  Fuka Aizawa; Yoshihiro Ogaki; Natsuki Kyoya; Takashi Nishinaka; Kazuo Nakamoto; Takashi Kurihara; Akira Hirasawa; Atsuro Miyata; Shogo Tokuyama

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2017, Peer-reviewed

  
• Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice

  Kazuo Nakamoto; Fuka Aizawa; Kei Miyagi; Takuya Yamashita; Mitsumasa Mankura; Yutaka Koyama; Fumiyo Kasuya; Akira Hirasawa; Takashi Kurihara; Atsuro Miyata; Shogo Tokuyama

  PLOS ONE, Jul. 2017, Peer-reviewed

  
• Intermittent hypoxia produces Alzheimer disease?

  Sosuke Yagishita; Akira Hirasawa

  ONCOTARGET, Jun. 2017, Peer-reviewed

  
• Fatty acid 16:4(n-3) stimulates a GPR120-induced signaling cascade in splenic macrophages to promote chemotherapy resistance

  Julia M. Houthuijzen; Ilse Oosterom; Brian D. Hudson; Akira Hirasawa; Laura G. M. Daenen; Chelsea M. McLean; Steffen V. F. Hansen; Marijn T. M. van Jaarsveld; Daniel S. Peeper; Sahar Jafari Sadatmand; Jeanine M. L. Roodhart; Chris H. A. van de Lest; Trond Ulven; Kenji Ishihara; Graeme Milligan; Emile E. Voest

  FASEB JOURNAL, May 2017, Peer-reviewed

  
• Long-Chain Free Fatty Acid Receptor GPR120 Mediates Oil-Induced GIP Secretion Through CCK in Male Mice

  Akiko Sankoda; Norio Harada; Kanako Iwasaki; Shunsuke Yamane; Yuki Murata; Kimitaka Shibue; Yotsapon Thewjitcharoen; Kazuyo Suzuki; Takanari Harada; Yoshinori Kanemaru; Satoko Shimazu-Kuwahara; Akira Hirasawa; Nobuya Inagaki

  ENDOCRINOLOGY, May 2017, Peer-reviewed

  
• Effects of arachidonic acid on FFA4 receptor: Signaling, phosphorylation and internalization

  S. Villegas-Comonfort; Y. Takei; G. Tsujimoto; A. Hirasawa; J. A. Garcia-Sainz

  PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, Feb. 2017, Peer-reviewed

  
• Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging

  Sosuke Yagishita; Seiya Suzuki; Keisuke Yoshikawa; Keiko Iida; Ayako Hirata; Masahiko Suzuki; Akihiko Takashima; Kei Maruyama; Akira Hirasawa; Takeo Awaji

  MOLECULAR BRAIN, Jan. 2017, Peer-reviewed

  
• GPR40/FFAR1 deficient mice increase noradrenaline levels in the brain and exhibit abnormal behavior

  Fuka Aizawa; Takashi Nishinaka; Takuya Yamashita; Kazuo Nakamoto; Takashi Kurihara; Akira Hirasawa; Fumiyo Kasuya; Atsuro Miyata; Shogo Tokuyama

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Dec. 2016, Peer-reviewed

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• [Free fatty acid receptors as therapeutic targets for metabolic disorders].

  Hirasawa A; Takeuchi M; Shirai R; Chen Z; Ishii S; Iida K

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Dec. 2015, Peer-reviewed

  
• Agonists and protein kinase C-activation induce phosphorylation and internalization of FFA1 receptors

  Carla Sosa-Alvarado; Aurelio Hernandez-Mendez; M. Teresa Romero-Avila; Omar B. Sanchez-Reyes; Yoshinori Takei; Gozoh Tsujimoto; Akira Hirasawa; J. Adolfo Garcia-Sainz

  EUROPEAN JOURNAL OF PHARMACOLOGY, Dec. 2015, Peer-reviewed

  
• The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats

  Junfeng Shi; Ning Liu; Ying Xiao; Yoshinori Takei; Misato Yasue; Yamato Suzuki; Zengye Hou; Hiroaki Ohno; Masateru Yamada; Nobuhiro Fuchi; Keiyu Oshida; Yohei Miyamoto; Gozoh Tsujimoto; Akira Hirasawa

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2015, Peer-reviewed

  
• Effects of a Tricaprylin Emulsion on Anti-glomerular Basement Membrane Glomerulonephritis in Rats: In Vivo and in Silico Studies

  Ning Liu; Junfeng Shi; Ying Xiao; Misato Yasue; Yoshinori Takei; Hayato Sanefuji; Gozoh Tsujimoto; Akira Hirasawa

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2015, Peer-reviewed

  
• Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening

  Isao Nakanishi; Katsumi Murata; Naoya Nagata; Masakuni Kurono; Takayoshi Kinoshita; Misato Yasue; Takako Miyazaki; Yoshinori Takei; Shinya Nakamura; Atsushi Sakurai; Nobuko Iwamoto; Keiji Nishiwaki; Tetsuko Nakaniwa; Yusuke Sekiguchi; Akira Hirasawa; Gozoh Tsujimoto; Kazuo Kitaura

  EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, May 2015, Peer-reviewed

  
• The oral lipid sensor GPR120 is not indispensable for the orosensory detection of dietary lipids in mice

  Deborah Ancel; Arnaud Bernard; Selvakumar Subramaniam; Akira Hirasawa; Gozoh Tsujimoto; Toshihiro Hashimoto; Patricia Passilly-Degrace; Naim-Akhtar Khan; Philippe Besnard

  JOURNAL OF LIPID RESEARCH, Feb. 2015, Peer-reviewed

  
• Fatty acids receptors

  Akira Hirasawa; Masato Takeuchi; Takafumi Hara; Ayako Hirata; Soshi Tanabe; Naoya Umeda

  Bioactive Lipid Mediators: Current Reviews and Protocols, 01 Jan. 2015, Peer-reviewed

  
• Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of the upper small intestine and has a critical role in GIP secretion after fat ingestion.

  Iwasaki K; Harada N; Sasaki K; Yamane S; Iida K; Suzuki K; Hamasaki A; Nasteska D; Shibue K; Joo E; Harada T; Hashimoto T; Asakawa Y; Hirasawa A; Inagaki N

  Endocrinology., 2015, Peer-reviewed

  
• Fish Oil Accelerates Diet-Induced Entrainment of the Mouse Peripheral Clock via GPR120.

  Akiko Furutani; Yuko Ikeda; Misa Itokawa; Hiroki Nagahama; Teiji Ohtsu; Naoki Furutani; Mayo Kamagata; Zhi-Hong Yang; Akira Hirasawa; Yu Tahara; Shigenobu Shibata

  PloS one, 2015, Peer-reviewed

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• Role of free fatty acid receptors in the regulation of energy metabolism.

  Takafumi Hara; Daiji Kashihara; Atsuhiko Ichimura; Ikuo Kimura; Gozoh Tsujimoto; Akira Hirasawa

  Biochimica et biophysica acta, Sep. 2014, Peer-reviewed

  
• Design and synthesis of fluorescent probes for GPR54

  Masato Kaneda; Ryosuke Misu; Hiroaki Ohno; Akira Hirasawa; Nahoko Ieda; Yoshihisa Uenoyama; Hiroko Tsukamura; Kei-Ichiro Maeda; Shinya Oishi; Nobutaka Fujii

  Bioorganic and Medicinal Chemistry, 01 Jul. 2014, Peer-reviewed

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• Free fatty acids and protein kinase C activation induce GPR120 (free fatty acid receptor 4) phosphorylation

  Omar B. Sanchez-Reyes; M. Teresa Romero-Avila; Jean A. Castillo-Badillo; Yoshinori Takei; Akira Hirasawa; Gozoh Tsujimoto; Rafael Villalobos-Molina; J. Adolfo Garcia-Sainz

  EUROPEAN JOURNAL OF PHARMACOLOGY, Jan. 2014, Peer-reviewed

  
• Therapeutic role and ligands of medium- to long-chain fatty acid receptors

  Takafumi Hara; Atsuhiko Ichimura; Akira Hirasawa

  FRONTIERS IN ENDOCRINOLOGY, 2014, Peer-reviewed

  
• Regulation of energy homeostasis via GPR120

  Atsuhiko Ichimura; Takafumi Hara; Akira Hirasawa

  FRONTIERS IN ENDOCRINOLOGY, 2014, Peer-reviewed

  
• FFA1-selective agonistic activity based on docking simulation using FFA1 and GPR120 homology models

  Masato Takeuchi; Akira Hirasawa; Takafumi Hara; Ikuo Kimura; Tatsuya Hirano; Takayoshi Suzuki; Naoki Miyata; Takeo Awaji; Masaji Ishiguro; Gozoh Tsujimoto

  BRITISH JOURNAL OF PHARMACOLOGY, Apr. 2013, Peer-reviewed

  
• Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors

  Zengye Hou; Shinya Oishi; Yamato Suzuki; Tatsuhide Kure; Isao Nakanishi; Akira Hirasawa; Gozoh Tsujimoto; Hiroaki Ohno; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, Peer-reviewed

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• Free fatty acid receptors and their role in regulation of energy metabolism.

  Takafumi Hara; Ikuo Kimura; Daisuke Inoue; Atsuhiko Ichimura; Akira Hirasawa

  Reviews of physiology, biochemistry and pharmacology, 2013, Peer-reviewed

  
• [Physiological functions of fatty acid receptors and their therapeutic potential].

  Takafumi Hara; Akira Hirasawa; Atsuhiko Ichimura; Ikuo Kimura; Gozoh Tsujimoto

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Dec. 2012, Peer-reviewed

  
• Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Yoshiaki Yano; Katsumi Matsuzaki; Jean-Marc Navenot; Stephen C. Peiper; Nobutaka Fujii

  BIOCONJUGATE CHEMISTRY, Jun. 2012, Peer-reviewed

  
• Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation

  Daisuke Inoue; Ikuo Kimura; Masaki Wakabayashi; Hiroki Tsumoto; Kentaro Ozawa; Takafumi Hara; Yoshinori Takei; Akira Hirasawa; Yasushi Ishihama; Gozoh Tsujimoto

  FEBS Letters, 21 May 2012, Peer-reviewed

  
• Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation

  Daisuke Inoue; Ikuo Kimura; Masaki Wakabayashi; Hiroki Tsumoto; Kentaro Ozawa; Takafumi Hara; Yoshinori Takei; Akira Hirasawa; Yasushi Ishihama; Gozoh Tsujimoto

  FEBS LETTERS, May 2012, Peer-reviewed

  
• Development and application of fluorescent SDF-1 derivatives

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  FUTURE MEDICINAL CHEMISTRY, May 2012, Peer-reviewed

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• Structure-Based Design Of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds

  Zengye Hou; Isao Nakanishi; Takayoshi Kinoshita; Yoshinori Takei; Misato Yasue; Ryosuke Misu; Yamato Suzuki; Shinya Nakamura; Tatsuhide Kure; Hiroald Ohno; Katsumi Murata; Kazuo Kitaura; Akira Hirasawa; Gozoh Tsujimoto; Shinya Oishi; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Mar. 2012, Peer-reviewed

  
• Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

  Atsuhiko Ichimura; Akira Hirasawa; Odile Poulain-Godefroy; Amelie Bonnefond; Takafumi Hara; Loic Yengo; Ikuo Kimura; Audrey Leloire; Ning Liu; Keiko Iida; Helene Choquet; Philippe Besnard; Cecile Lecoeur; Sidonie Vivequin; Kumiko Ayukawa; Masato Takeuchi; Kentaro Ozawa; Maithe Tauber; Claudio Maffeis; Anita Morandi; Raffaella Buzzetti; Paul Elliott; Anneli Pouta; Marjo-Riitta Jarvelin; Antje Koerner; Wieland Kiess; Marie Pigeyre; Roberto Caiazzo; Wim Van Hul; Luc Van Gaal; Fritz Horber; Beverley Balkau; Claire Levy-Marchal; Konstantinos Rouskas; Anastasia Kouvatsi; Johannes Hebebrand; Anke Hinney; Andre Scherag; Francois Pattou; David Meyre; Taka-aki Koshimizu; Isabelle Wolowczuk; Gozoh Tsujimoto; Philippe Froguel

  NATURE, Mar. 2012, Peer-reviewed

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• Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles

  Yamato Suzuki; Shinya Oishi; Yoshinori Takei; Misato Yasue; Ryosuke Misu; Saori Naoe; Zengye Hou; Tatsuhide Kure; Isao Nakanishi; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, Peer-reviewed

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• Free Fatty Acid Receptors and Their Physiological Role in Metabolic Regulation

  Akira Hirasawa; Takafumi Hara; Atsuhiko Ichimura; Gozoh Tsujimoto

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2011, Peer-reviewed

  
• 消化管脂肪酸受容体とその生理作用

  平澤 明; 原 貴史; 市村 敦彦; 辻本 豪三

  薬学雑誌, Dec. 2011, Peer-reviewed

  
• A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase

  Takayoshi Kinoshita; Yusuke Sekiguchi; Harumi Fukada; Tetsuko Nakaniwa; Toshiji Tada; Shinya Nakamura; Kazuo Kitaura; Hiroaki Ohno; Yamato Suzuki; Akira Hirasawa; Isao Nakanishi; Gozoh Tsujimoto

  MOLECULAR AND CELLULAR BIOCHEMISTRY, Oct. 2011, Peer-reviewed

  
• Free Fatty Acid Receptors FFAR1 and GPR120 as Novel Therapeutic Targets for Metabolic Disorders

  Takafumi Hara; Akira Hirasawa; Atsuhiko Ichimura; Ikuo Kimura; Gozoh Tsujimoto

  JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2011, Peer-reviewed

  
• Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands

  Shinya Oishi; Ryosuke Misu; Kenji Tomita; Shohei Setsuda; Ryo Masuda; Hiroaki Ohno; Yousuke Naniwa; Nahoko Ieda; Naoko Inoue; Satoshi Ohkura; Yoshihisa Uenoyama; Hiroko Tsukamura; Kei-ichiro Maeda; Akira Hirasawa; Gozoh Tsujimoto; Nobutaka Fujii

  ACS MEDICINAL CHEMISTRY LETTERS, Jan. 2011, Peer-reviewed

  
• 脂肪酸受容体GPR120機能不全は食餌誘発性の肥満及び脂肪肝を惹起する

  市村 敦彦; 平澤 明; 宮内 諭; 木村 郁夫; 鮎川 公美子; 竹内 理人; 辻本 豪三

  血管, Jan. 2011, Peer-reviewed

  
• Structure-Activity Relationships of GPR120 Agonists Based on a Docking Simulation

  Qi Sun; Akira Hirasawa; Takafumi Hara; Ikuo Kimura; Tetsuya Adachi; Takeo Awaji; Masaji Ishiguro; Takayoshi Suzuki; Naoki Miyata; Gozoh Tsujimoto

  MOLECULAR PHARMACOLOGY, Nov. 2010, Peer-reviewed

  
• GPR120の遺伝子多型(Arg67Cys)と2型糖尿病の関連の検討

  村上 智史; 永瀬 晃正; 三井 雅子; 鮎川 公美子; 市村 敦彦; 孫 き; 平澤 明; 辻本 豪三; 桂 善也

  糖尿病, Apr. 2010, Peer-reviewed

  
• Neuferricin, a novel extracellular heme-binding protein, promotes neurogenesis

  Ikuo Kimura; Yoshiaki Nakayama; Morichika Konishi; Teruyuki Kobayashi; Masahiro Mori; Masaki Ito; Akira Hirasawa; Gozoh Tsujimoto; Mitsuhiro Ohta; Nobuyuki Itoh; Masafumi Fujimoto

  JOURNAL OF NEUROCHEMISTRY, Mar. 2010, Peer-reviewed

  
• 短鎖脂肪酸受容体GPR41の生体における発現解析

  井上 大輔; 木村 郁夫; 前田 岳志; 宮内 諭; 市村 敦彦; 平澤 明; 辻本 豪三

  日本薬理学雑誌, Mar. 2010, Peer-reviewed

  
• ヒトGPR120遺伝子多型の機能解析

  鮎川 公美子; 市村 敦彦; 孫 き; 村上 智史; 永瀬 晃正; 平澤 明; 辻本 豪三

  日本薬学会年会要旨集, Mar. 2010, Peer-reviewed

  
• Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment

  Taka-aki Koshimizu; Hiroyoshi Tsuchiya; Hidetoshi Tsuda; Yoko Fujiwara; Katsushi Shibata; Akira Hirasawa; Gozoh Tsujimoto; Akio Fujimura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2010, Peer-reviewed

  
• New Frontiers in Gut Nutrient Sensor Research: Free Fatty Acid Sensing in the Gastrointestinal Tract

  Satoshi Miyauchi; Akira Hirasawa; Atsuhiko Ichimura; Takafumi Hara; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jan. 2010, Peer-reviewed

  
• 短鎖脂肪酸受容体の交感神経を介した循環器系機能へ及ぼす影響

  木村 郁夫; 井上 大輔; 前田 岳志; 宮内 諭; 市村 敦彦; 平澤 明; 辻本 豪三

  血管, Jan. 2010, Peer-reviewed

  
• Novel selective ligands for free fatty acid receptors GPR120 and GPR40

  Takafumi Hara; Akira Hirasawa; Qi Sun; Keiko Sadakane; Chisato Itsubo; Tomoyo Iga; Tetsuya Adachi; Taka-aki Koshimizu; Toshihiro Hashimoto; Yoshinori Asakawa; Gozoh Tsujimoto

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Sep. 2009, Peer-reviewed

  
• Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis

  Atsuhiko Ichimura; Akira Hirasawa; Takafumi Hara; Gozoh Tsujimoto

  PROSTAGLANDINS & OTHER LIPID MEDIATORS, Sep. 2009, Peer-reviewed

  
• Structural insight into human CK2 alpha in complex with the potent inhibitor ellagic acid

  Yusuke Sekiguchi; Tetsuko Nakaniwa; Takayoshi Kinoshita; Isao Nakanishi; Kazuo Kitaura; Akira Hirasawa; Gozoh Tsujimoto; Toshiji Tada

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jun. 2009, Peer-reviewed

  
• Distribution and regulation of protein expression of the free fatty acid receptor GPR120

  Satoshi Miyauchi; Akira Hirasawa; Tomoyo Iga; Ning Liu; Chisato Itsubo; Keiko Sadakane; Takafumi Hara; Gozoh Tsujimoto

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Apr. 2009, Peer-reviewed

  
• Neudesin, an extracellular heme-binding protein, suppresses adipogenesis in 3T3-L1 cells via the MAPK cascade

  Ikuo Kimura; Morichika Konishi; Toshiyuki Asaki; Naoko Furukawa; Kiyotaka Ukai; Masahiro Mori; Akira Hirasawa; Gozoh Tsujimoto; Mitsuhiro Ohta; Nobuyuki Itoh; Masafumi Fujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2009, Peer-reviewed

  
• Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor

  Tetsuko Nakaniwa; Takayoshi Kinoshita; Yusuke Sekiguchi; Toshiji Tada; Isao Nakanishi; Kazuo Kitaura; Yamato Suzuki; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Feb. 2009, Peer-reviewed

  
• Flow Cytometry-Based Binding Assay for GPR40 ( FFAR1; Free Fatty Acid Receptor 1)

  Takafumi Hara; Akira Hirasawa; Qi Sun; Taka-Aki Koshimizu; Chisato Itsubo; Keiko Sadakane; Takeo Awaji; Gozoh Tsujimoto

  MOLECULAR PHARMACOLOGY, Jan. 2009, Peer-reviewed

  
• Identification of G protein-coupled receptor 120-selective agonists derived from PPARγ agonists

  Takayoshi Suzuki; Sou Ichi Igari; Akira Hirasawa; Mie Hata; Masaji Ishiguro; Hiroki Fujieda; Yukihiro Itoh; Tatsuya Hirano; Hidehiko Nakagawa; Michitaka Ogura; Makoto Makishima; Gozoh Tsujimoto; Naoki Miyata

  Journal of Medicinal Chemistry, 11 Dec. 2008, Peer-reviewed

  
• Free fatty acid receptors and drug discovery

  Akira Hirasawa; Takafumi Hara; Susumu Katsuma; Tetsuya Adachi; Gozoh Tsujimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2008, Peer-reviewed

  
• Structure-activity relationships of pyrazine-based CK2 inhibitors: Synthesis and evaluation of 2,6-disubstituted pyrazines and 4,6-disubstituted pyrimidines

  Yarnato Suzuki; Jerome Cluzeau; Takafumi Hara; Akira Hirasawa; Gozoh Tsujimoto; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  ARCHIV DER PHARMAZIE, Sep. 2008, Peer-reviewed

  
• Free fatty acids induce cholecystokinin secretion through GPR120

  Toshiki Tanaka; Susumu Katsuma; Tetsuya Adachi; Taka-Aki Koshimizu; Akira Hirasawa; Gozoh Tsujimoto

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Jun. 2008, Peer-reviewed

  
• Cloning and characterization of the rat free fatty acid receptor GPR120: in vivo effect of the natural ligand on GLP-1 secretion and proliferation of pancreatic beta cells

  Toshiki Tanaka; Takeaki Yano; Tetsuya Adachi; Taka-aki Koshimizu; Akira Hirasawa; Gozoh Tsujimoto

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Jun. 2008, Peer-reviewed

  
• Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4

  Shinya Oishi; Ryo Masuda; Barry Evans; Satoshi Ueda; Yukiko Goto; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Zixuan Wang; Stephen C. Peiper; Takeshi Naito; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  CHEMBIOCHEM, May 2008, Peer-reviewed

  
• Administration of perilla oil coated with Calshell increases glucagon-like peptide secretion

  Tetsuya Adachi; Hiroyuki Yanaka; Hitoshi Kanai; Mayu Nozaki; Yoshiyuki Takahara; Mariko Tsuda; Tatsuya Jonouchi; Kinsuke Tsuda; Akira Hirasawa; Gozoh Tsujimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2008, Peer-reviewed

  
• In silico approach to identify the expression of the undiscovered molecules from microarray public database: identification of odorant receptors expressed in non-olfactory tissues

  Atsuhiko Ichimura; Tadashi Kadowaki; Kayo Narukawa; Kayo Togiya; Akira Hirasawa; Gozoh Tsujimoto

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Apr. 2008, Peer-reviewed

  
• Production and characterization of a monoclonal antibody, against GPR40 (FFAR1; free fatty acid receptor 1)

  Akira Hirasawa; Chisato Itsubo; Keiko Sadakane; Takafumi Hara; Shingo Shinagawa; Hanako Koga; Hiroshi Nose; Taka-aki Koshimizu; Gozoh Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2008, Peer-reviewed

  
• Immunological tolerance-related genes in a spontaneous tolerant model of rat liver transplantation explored by suppression subtractive hybridization

  HuiQi Zhang; Kazuhiro Ohmi; Akira Hirasawa; Shin Enosawa; Yoshiaki Hara; Akihiko Tamura; Gozoh Tsujimoto

  CELL TRANSPLANTATION, 2008, Peer-reviewed

  
• The regulation of adipogenesis through GPR120

  Chizu Gotoh; Yeon-Hee Hong; Tomoyo Iga; Daisuke Hishikawa; Yasuki Suzuki; Sang-Houn Song; Ki-Choon Choi; Tetsuya Adachi; Akira Hirasawa; Gozoh Tsujimoto; Shin-ichi Sasaki; Sang-Gun Roh

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2007, Peer-reviewed

  
• Glucocorticoid-induced alternative promoter usage for a novel 5 ' variant of granzyme A

  Yoshinao Ruike; Susumu Katsuma; Akira Hirasawa; Gozoh Tsujimoto

  JOURNAL OF HUMAN GENETICS, Feb. 2007, Peer-reviewed

  
• Monitoring ligand-mediated internalization of G protein-coupled receptor as a novel pharmacological approach

  Shin'ichi Fukunaga; Shingo Setoguchi; Akira Hirasawa; Gozoh Tsujimoto

  LIFE SCIENCES, Dec. 2006, Peer-reviewed

  
• Free fatty acids administered into the colon promote the secretion of glucagon-like peptide-1 and insulin

  T Adachi; T Tanaka; K Takemoto; TA Koshimizu; A Hirasawa; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2006, Peer-reviewed

  
• Developmental aberrations of liver gene expression in bovine fetuses derived from somatic cell nuclear transplantation

  Chandana B. Herath; Hiroko Ishiwata; Satoshi Shiojima; Tadashi Kadowaki; Susumu Katsuma; Koichi Ushizawa; Kei Imai; Toru Takahashi; Akira Hirasawa; Seiya Takahashi; Yoshiaki Izaike; Gozoh Tsujimoto; Kazuyoshi Hashizume

  Cloning and Stem Cells, 2006, Peer-reviewed

  
• Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1

  S Katsuma; N Hatae; T Yano; Y Ruike; M Kimura; A Hirasawa; G Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2005, Peer-reviewed

  
• Transcriptional regulation of connective tissue growth factor by sphingosine 1-phosphate in rat cultured mesangial cells

  S Katsuma; Y Ruike; T Yano; M Kimura; A Hirasawa; G Tsujimoto

  FEBS LETTERS, May 2005, Peer-reviewed

  
• Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1

  S Katsuma; A Hirasawa; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2005, Peer-reviewed

  
• オーファン受容体GPR120のリガンド探索と機能解析

  平澤 明; 妻屋 恵子; 淡路 健雄; 勝間 進; 足達 哲也; 山田 将輝; 杉本 幸彦; 宮崎 俊一; 辻本 豪三

  日本薬学会年会要旨集, Mar. 2005, Peer-reviewed

  
• Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

  A Hirasawa; K Tsumaya; T Awaji; S Katsuma; T Adachi; M Yamada; Y Sugimoto; S Miyazaki; G Tsujimoto

  NATURE MEDICINE, Jan. 2005, Peer-reviewed

  
• Ligand identification and functional analysis for orphan GPCR GPR120

  A Hirasawa; G Tsujimoto

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, Peer-reviewed

  
• cDNA microarray analysis of bovine embryo gene expresion profiles during the pre-implantation period

  Koichi Ushizawa; Chandana B. Herath; Kanako Kaneyama; Satoshi Shiojima; Akira Hirasawa; Toru Takahashi; Kei Imai; Kazuhiko Ochiai; Tomoyuki Tokunaga; Yukio Tsunoda; Gozoh Tsujimoto; Kazuyoshi Hashizume

  Reproductive Biology and Endocrinology, 24 Nov. 2004, Peer-reviewed

  
• Gene expression profile in experimental mesangial proliferative glomerulonephritis

  Y Izumi; Y Izumiya; M Shiota; T Yukimura; S Shiojima; M Yamada; T Kadowaki; S Katsuma; A Hirasawa; G Tsujimoto; H Iwao

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Sep. 2004, Peer-reviewed

  
• Carvedilol selectively inhibits oscillatory intracellular calcium changes evoked by human alpha 1D- and alpha-1B-adrenergic receptors

  T Koshimizu; G Tsujimoto; A Hirasawa; Y Kitagawa; A Tanoue

  CARDIOVASCULAR RESEARCH, Sep. 2004, Peer-reviewed

  
• Outline of treatment for endometrial cancer

  D. Aoki; A. Hirasawa; N. Susumu; S. Nozawa

  Nippon rinsho. Japanese journal of clinical medicine, 2004, Peer-reviewed

  
• Pregnancy-associated changes in genome-wide gene expression profiles in the liver of cow throughout pregnancy

  CB Herath; S Shiojima; H Ishiwata; S Katsuma; T Kadowaki; K Ushizawa; K Imai; T Takahashi; A Hirasawa; G Tsujimoto; K Hashizume

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2004, Peer-reviewed

  
• Unfavorable prognostic factors associated with high frequency of microsatellite instability and comparative genomic hybridization analysis in endometrial cancer

  A Hirasawa; D Aoki; J Inoue; Imoto, I; N Susumu; K Sugano; S Nozawa; J Inazawa

  CLINICAL CANCER RESEARCH, Nov. 2003, Peer-reviewed

  
• Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells.

  M. Yamada; A. Hirasawa; S. Shiojima; G. Tsujimoto

  The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Sep. 2003, Peer-reviewed

  
• Gene expression profile in the regenerating rat liver after partial hepatectomy

  Y Fukuhara; A Hirasawa; XK Li; M Kawasaki; M Fujino; N Funeshima; S Katsuma; S Shiojima; M Yamada; T Okuyama; S Suzuki; G Tsujimoto

  JOURNAL OF HEPATOLOGY, Jun. 2003, Peer-reviewed

  
• Recent advances in alpha(1)-adrenoceptor pharmacology

  T Koshimizu; A Tanoue; A Hirasawa; J Yamauchi; G Tsujimoto

  PHARMACOLOGY & THERAPEUTICS, May 2003, Peer-reviewed

  
• Characterization of gene expression profiles in early bovine pregnancy using a custom cDNA microarray

  H Ishiwata; S Katsuma; K Kizaki; OV Patel; H Nakano; T Takahashi; K Imai; A Hirasawa; S Shiojima; H Ikawa; Y Suzuki; G Tsujimoto; Y Izaike; J Todoroki; K Hashizume

  MOLECULAR REPRODUCTION AND DEVELOPMENT, May 2003, Peer-reviewed

  
• Recent advances in alpha(1)-adrenoceptor pharmacology

  T Koshimizu; A Tanoue; A Hirasawa; J Yamauchi; G Tsujimoto

  PHARMACOLOGY & THERAPEUTICS, May 2003, Peer-reviewed

  
• Agonist-specific coupling of a cloned human alpha(1A)-adrenoceptor to different second messenger pathways

  J Richardson; H Chatwin; A Hirasawa; G Tsujimoto; PD Evans

  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, Apr. 2003, Peer-reviewed

  
• Temporal gene expression changes during adipogenesis in human mesenchymal stem cells

  T Nakamura; S Shiojima; Y Hirai; T Iwama; N Tsuruzoe; A Hirasawa; S Katsuma; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2003, Peer-reviewed

  
• 分娩後のウシ子宮内膜上皮におけるPAGファミリーの遺伝子発現について

  橋爪 一善; 石渡 広子; 坂口 実; 片桐 成二; 木崎 景一郎; 今井 敬; 高橋 透; 平澤 明; 塩島 聡; 勝間 進; 辻本 豪三

  日本畜産学会大会講演要旨集, Mar. 2003, Peer-reviewed

  
• ウシの子宮および胎盤における発現遺伝子の解析

  石渡 広子; 高橋 透; 今井 敬; 木崎 景一郎; 平澤 明; 塩島 聡; 勝間 進; 辻本 豪三; 橋爪 一善

  日本畜産学会大会講演要旨集, Mar. 2003, Peer-reviewed

  
• ウシ肝臓cDNAマイクロアレイの作成とその評価

  Herath Chandana; 石渡 広子; 高橋 透; 今井 敬; 平澤 明; 塩島 聡; 勝間 進; 辻本 豪三; 橋爪 一善

  日本畜産学会大会講演要旨集, Mar. 2003, Peer-reviewed

  
• Association of 17q21-q24 gain in ovarian clear cell adenocarcinomas with poor prognosis and identification of PPM1D and APPBP2 as likely amplification targets

  A. Hirasawa; F. Saito-Ohara; J. Inoue; D. Aoki; N. Susumu; T. Yokoyama; S. Nozawa; J. Inazawa; I. Imoto

  Clinical Cancer Research, 2003, Peer-reviewed

  
• Transcriptional profiling of gene expression patterns during sphingosine 1-phosphate-induced mesangial cell proliferation

  S Katsuma; Y Hada; S Shiojima; A Hirasawa; A Tanoue; K Takagaki; T Ohgi; J Yano; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2003, Peer-reviewed

  
• alpha(1)-adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27(KiP1)

  K Shibata; S Katsuma; T Koshimizu; H Shinoura; A Hirasawa; A Tanoue; G Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2003, Peer-reviewed

  
• Signalling mechanisms in sphingosine 1-phosphate-promoted mesangial cell proliferation

  S Katsuma; Y Hada; T Ueda; S Shiojima; A Hirasawa; A Tanoue; K Takagaki; T Ohgi; J Yano; G Tsujimoto

  GENES TO CELLS, Dec. 2002, Peer-reviewed

  
• Key amino acids for differential coupling of alpha 1-adrenergic receptor subtypes to Gs

  H Shinoura; K Shibata; A Hirasawa; A Tanoue; K Hashimoto; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2002, Peer-reviewed

  
• Key amino acids for differential coupling of alpha 1-adrenergic receptor subtypes to Gs

  H Shinoura; K Shibata; A Hirasawa; A Tanoue; K Hashimoto; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2002, Peer-reviewed

  
• Endothelin suppresses cell migration via the JNK signaling pathway in a manner dependent upon Src kinase, Rac1, and Cdc42

  J Yamauchi; Y Miyamoto; H Kokubu; H Nishii; M Okamoto; Y Sugawara; A Hirasawa; G Tsujimoto; H Itoh

  FEBS LETTERS, Sep. 2002, Peer-reviewed

  
• Global analysis of differentially expressed genes during progression of calcium oxalate nephrolithiasis

  S Katsuma; S Shiojima; A Hirasawa; K Takagaki; Y Kaminishi; M Koba; Y Hagidai; M Murai; T Ohgi; J Yano; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2002, Peer-reviewed

  
• Role of Dbl's big sister in the anti-mitogenic pathway from alpha 1B-adrenergic receptor to c-Jun N-terminal kinase

  J Yamauchi; A Hirasawa; Y Miyamoto; H Kokubu; H Nishii; M Okamoto; Y Sugawara; G Tsujimoto; H Itoh

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2002, Peer-reviewed

  
• cDNAマイクロアレイによるラット糸球体腎炎モデルの発現遺伝子の解析

  山田 将輝; 平澤 明; 塩島 聡; 勝間 進; 辻本 豪三

  生化学, Aug. 2002, Peer-reviewed

  
• Role of Dbl's big sister in the anti-mitogenic pathway from alpha 1B-adrenergic receptor to c-Jun N-terminal kinase

  J Yamauchi; A Hirasawa; Y Miyamoto; H Kokubu; H Nishii; M Okamoto; Y Sugawara; G Tsujimoto; H Itoh

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2002, Peer-reviewed

  
• Recent progress in alpha(1)-adrenoceptor pharmacology

  T Koshimizu; J Yamauchi; A Hirasawa; A Tanoue; G Tsujimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2002, Peer-reviewed

  
• Recent progress in alpha(1)-adrenoceptor pharmacology

  T Koshimizu; J Yamauchi; A Hirasawa; A Tanoue; G Tsujimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2002, Peer-reviewed

  
• Differences in the subcellular localization of alpha(1)-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin

  T Sugawara; A Hirasawa; K Hashimoto; G Tsujimoto

  LIFE SCIENCES, Mar. 2002, Peer-reviewed

  
• Differences in the subcellular localization of alpha(1)-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin

  T Sugawara; A Hirasawa; K Hashimoto; G Tsujimoto

  LIFE SCIENCES, Mar. 2002, Peer-reviewed

  
• Implantation and placental development in somatic cell clone recipient cows

  Kazuyoshi Hashizume; Hiroko Ishiwata; Keiichiro Kizaki; Osamu Yamada; Toru Takahashi; Kei Imai; Osman V. Patel; Satoshi Akagi; Manabu Shimizu; Seiya Takahashi; Susumu Katsuma; Satoshi Shiojima; Akira Hirasawa; Gozo Tsujimoto; Junichi Todoroki; Yoshiaki Izaike

  Cloning and Stem Cells, 2002, Peer-reviewed

  
• SNP genotyping in the beta(2)-adrenergic receptor by electronic microchip assay, DHPLC, and direct sequencing

  N Yoshida; Y Nishimaki; M Sugiyama; T Abe; T Tatsumi; A Tanoue; A Hirasawa; G Tsujimoto

  JOURNAL OF HUMAN GENETICS, 2002, Peer-reviewed

  
• Functional genomic search of G-protein-coupled receptors using microarrays with normalized cDNA library

  S Katsuma; S Shiojima; A Hirasawa; Y Suzuki; H Ikawa; K Takagaki; Y Kaminishi; M Murai; T Ohgi; J Yano; G Tsujimoto

  G PROTEIN PATHWAYS: PT C, EFFECTOR MECHANISMS, 2002, Peer-reviewed

  
• Functional genornic research of alpha 1-adrenoceptors

  G Tsujimoto; S Katsuma; S Shiojima; A Hirasawa; A Tanoue

  PHARMACOGENETICS - TAILOR-MADE PHARMACOTHERAPY, 2002, Peer-reviewed

  
• Functional genomic search of G-protein-coupled receptors using microarrays with normalized cDNA library

  S Katsuma; S Shiojima; A Hirasawa; Y Suzuki; H Ikawa; K Takagaki; Y Kaminishi; M Murai; T Ohgi; J Yano; G Tsujimoto

  G PROTEIN PATHWAYS: PT C, EFFECTOR MECHANISMS, 2002, Peer-reviewed

  
• Determination of a Novel Haplotype of b2-adrenergic Receptor in the Japanese Population by the Combination of the Electronic Microchip Assay Using the NanoChip System with Allele-speciôc PCR

  Nobuyo Yoshida; Masahide Sugiyama; Akito Tanoue; Akira Hirasawa; Gozoh Tsujimoto; Hirohisa Saito

  Drug Metabolism and Pharmacokinetics, 2002, Peer-reviewed

  
• ヒットピッキング法により作成したウシ子宮・胎盤cDNAマイクロアレイの特性

  石渡 広子; 木崎 景一郎; 中野 博子; 今井 敬; 高橋 透; 平澤 明; 塩島 聡; 勝間 進; 鈴木 康仁; 伊川 浩司

  The Journal of Reproduction and Development, Dec. 2001, Peer-reviewed

  
• Novel green fluorescent protein-based ratiometric indicators for monitoring pH in defined intracellular microdomains

  T Awaji; A Hirasawa; H Shirakawa; G Tsujimoto; S Miyazaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2001, Peer-reviewed

  
• G alpha q-dependent activation of mitogen-activated protein kinase kinase 4/c-Jun N-terminal kinase cascade

  J Yamauchi; H Itoh; H Shinoura; Y Miyamoto; K Tsumaya; A Hirasawa; Y Kaziro; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2001, Peer-reviewed

  
• Molecular monitoring of bleomycin-induced pulmonary fibrosis by cDNA microarray-based gene expression profiling

  S Katsuma; K Nishi; K Tanigawara; H Ikawa; S Shiojima; K Takagaki; Y Kaminishi; Y Suzuki; A Hirasawa; T Ohgi; J Yano; Y Murakami; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2001, Peer-reviewed

  
• Functional genomic research of alpha(1)-adrenoceptors

  G Tsujimoto; S Katsuma; S Shiojima; A Hirasawa; A Tanoue

  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Oct. 2001, Peer-reviewed

  
• In vivo antiarrhythmic profile of AP-792 assessed in different canine arrhythmia models

  A Takahara; A Hirasawa; H Dohmoto; M Shoji; R Yoshimoto; A Sugiyama; K Hashimoto

  JAPANESE JOURNAL OF PHARMACOLOGY, Sep. 2001, Peer-reviewed

  
• beta 2-adrenergic receptor/cyclic adenosine monophosphate (cAMP) leads to JNK activation through Rho family small GTPases

  J Yamauchi; A Hirasawa; Y Miyamoto; H Itoh; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2001, Peer-reviewed

  
• Regulation of subcellular localization of alpha(1)-adrenoceptor subtypes

  A Hirasawa; T Awaji; ZJ Xu; H Shinoura; G Tsujimoto

  LIFE SCIENCES, Apr. 2001, Peer-reviewed

  
• Involvement of c-jun N-terminal kinase and p38 mitogen-activated protein kinase in alpha 1B-adrenergic receptor/G alpha q-induced inhibition of cell proliferation

  J Yamauchi; H Itoh; H Shinoura; Y Miyamoto; A Hirasawa; Y Kaziro; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2001, Peer-reviewed

  
• Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF-EDG5 cascade.

  Katsuma S; Shiojima S; Hirasawa A; Suzuki Y; Takagaki K; Murai M; Kaminishi Y; Hada Y; Koba M; Muso E; Miyawaki S; Ohgi T; Yano J; Tsujimoto G

  The pharmacogenomics journal, 2001, Peer-reviewed

  
• Erratum: Key amino acids of vasopressin V1a receptor responsible for the species difference in the affinity of OPC-21268 (FEBS 23227) (FEBS Letters 466 (2000) (255-258) PII: S0014579300010796)

  Hitomi Shinoura; Hitoshi Take; Shuji Itoh; Akira Hirasawa; Kazuhide Inoue; Yasuo Ohno; Keitaro Hashimoto; Gozoh Tsujimoto

  FEBS Letters, 02 Jun. 2000, Peer-reviewed

  
• Both alpha(1A)- and alpha(1B)-adrenergic receptor subtypes couple to the transient outward current (I-To) in rat ventricular myocytes

  N Homma; A Hirasawa; K Shibata; K Hashimito; G Tsujimoto

  BRITISH JOURNAL OF PHARMACOLOGY, Mar. 2000, Peer-reviewed

  
• Key amino acids of vasopressin V1a receptor responsible for the species difference in the affinity of OPC-21268

  H Shinoura; H Take; A Hirasawa; K Inoue; Y Ohno; K Hashimoto; G Tsujimoto

  FEBS LETTERS, Jan. 2000, Peer-reviewed

  
• Interaction of the alpha(1B)-adrenergic receptor with gC1q-R, a multifunctional protein

  ZJ Xu; A Hirasawa; H Shinoura; G Tsujimoto

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1999, Peer-reviewed

  
• Two soluble forms of beta 1,4-galactosyltransferase released from ovarian cancer cells and from COS-1 cells transfected with its cDNA

  D Aoki; E Saitoh; Y Matsumoto; E Tominaga; A Hirasawa; N Susumu; Y Udagawa; S Nozawa

  ACTA HISTOCHEMICA ET CYTOCHEMICA, 1999, Peer-reviewed

  
• Real-time optical monitoring of ligand-mediated internalization of alpha(1b)-adrenoceptor with green fluorescent protein

  T Awaji; A Hirasawa; M Kataoka; H Shinoura; Y Nakayama; T Sugawara; S Izumi; G Tsujimoto

  MOLECULAR ENDOCRINOLOGY, Aug. 1998, Peer-reviewed

  
• Differential mechanism for the cell surface sorting and agonist-promoted internalization of the alpha(1B)-adrenoceptor

  A Hirasawa; T Awaji; T Sugawara; A Tsujimoto; G Tsujimoto

  BRITISH JOURNAL OF PHARMACOLOGY, May 1998, Peer-reviewed

  
• Vascular alpha(1)-adrenoceptor subtype selectivity and alpha(1)-blocker-induced orthostatic hypotension

  H Take; K Shibata; T Awaji; A Hirasawa; Ikegaki, I; T Asano; T Takada; G Tsujimoto

  JAPANESE JOURNAL OF PHARMACOLOGY, May 1998, Peer-reviewed

  
• Effects of quinidine and verapamil on human cardiovascular alpha(1)-adrenoceptors

  K Shibata; A Hirasawa; R Foglar; S Ogawa; G Tsujimoto

  CIRCULATION, Apr. 1998, Peer-reviewed

  
• Subtype-specific differences in subcellular localization and chlorethylclonidine inactivation of alpha 1-adrenoceptors

  G Tsujimoto; A Hirasawa; T Sugawara; T Awaji

  LIFE SCIENCES, Mar. 1998, Peer-reviewed

  
• Subtype-specific differences in subcellular localization of alpha(1)-adrenoceptors: Chlorethylclonidine preferentially alkylates the accessible cell surface alpha(1)-adrenoceptors irrespective of the subtype

  A Hirasawa; T Sugawara; T Awaji; K Tsumaya; H Ito; G Tsujimoto

  MOLECULAR PHARMACOLOGY, Nov. 1997, Peer-reviewed

  
• alpha(1a)-adrenoceptor polymorphism: Pharmacological characterization and association with benign prostatic hypertrophy

  K Shibata; A Hirasawa; N Moriyama; K Kawabe; S Ogawa; G Tsujimoto

  BRITISH JOURNAL OF PHARMACOLOGY, Jul. 1996, Peer-reviewed

  
• alpha(1b)-Adrenoceptor-mediated calcium oscillation is specific for the S phase in cell cycle and dependent on the extracellular calcium

  T Awaji; S Izumi; K Horie; A Hirasawa; G Tsujimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1996, Peer-reviewed

  
• Flow cytometry analysis of alpha(1)-adrenoceptor subtypes

  A Hirasawa; K Tsumaya; T Awaji; K Shibata; N Homma; T Shinomiya; G Tsujimoto

  FEBS LETTERS, May 1996, Peer-reviewed

  
• Oxytocin receptors expressed and coupled to Ca2+ signalling in a human vascular smooth muscle cell line

  H Yazawa; A Hirasawa; K Horie; Y Saita; E Iida; K Honda; G Tsujimoto

  BRITISH JOURNAL OF PHARMACOLOGY, Mar. 1996, Peer-reviewed

  
• DISTRIBUTION AND DEVELOPMENTAL-CHANGES IN VASOPRESSIN V-2 RECEPTOR MESSENGER-RNA IN RAT-BRAIN

  Y KATO; N IGARASHI; A HIRASAWA; G TSUJIMOTO; M KOBAYASHI

  DIFFERENTIATION, Oct. 1995, Peer-reviewed

  
• CLONING OF THE HUMAN ALPHA(1D)-ADRENERGIC RECEPTOR AND INDUCIBLE EXPRESSION OF 3 HUMAN SUBTYPES IN SK-N-MC CELLS

  TA ESBENSHADE; A HIRASAWA; G TSUJIMOTO; T TANAKA; J YANO; KP MINNEMAN; TJ MURPHY

  MOLECULAR PHARMACOLOGY, May 1995, Peer-reviewed

  
• EFFECTS OF THE NEW CLASS-III ANTIARRHYTHMIC DRUG MS-551 AND D-SOTALOL ON CANINE CORONARY LIGATION-REPERFUSION VENTRICULAR ARRHYTHMIAS

  K HASHIMOTO; A HARUNO; A HIRASAWA; T AWAJI; YX XUE; ZJ WU

  JAPANESE JOURNAL OF PHARMACOLOGY, May 1995, Peer-reviewed

  
• CLONING, FUNCTIONAL EXPRESSION AND TISSUE DISTRIBUTION OF HUMAN ALPHA(1C)-ADRENOCEPTOR SPLICE VARIANTS

  A HIRASAWA; K SHIBATA; K HORIE; Y TAKEI; K OBIKA; T TANAKA; N MURAMOTO; K TAKAGAKI; J YANO; G TSUJIMOTO

  FEBS LETTERS, Apr. 1995, Peer-reviewed

  
• MICROCHIMERISM AND LUNG ALLOGRAFT ACCEPTANCE

  M HARA; K SHIBATA; A HIRASAWA; M IWAYA; S OKUYAMA; G TSUJIMOTO; H KIMURA; Y KOGA

  TRANSPLANTATION PROCEEDINGS, Apr. 1995, Peer-reviewed

  
• MODULATION OF ANGIOTENSIN-II TYPE-1 RECEPTOR MESSENGER-RNA EXPRESSION IN HUMAN BLOOD-CELLS - COMPARISON OF PLATELETS AND MONONUCLEAR LEUKOCYTES

  H SUZUKI; H SHIBATA; M MURAKAMI; A SATO; M NAITO; A ICHIHARA; A MATSUMOTO; G TSUJIMOTO; A HIRASAWA; K HORIE; T SARUTA

  ENDOCRINE JOURNAL, Feb. 1995, Peer-reviewed

  
• Flow cytometry and laser scanning confocal microscopy analysis of the receptor distribution

  A. Hirasawa; T. Awaji; G. Tsujimoto

  Folia Pharmacologica Japonica, 1995, Peer-reviewed

  
• USE OF RECOMBINANT ALPHA(1)-ADRENOCEPTORS TO CHARACTERIZE SUBTYPE SELECTIVITY OF DRUGS FOR THE TREATMENT OF PROSTATIC HYPERTROPHY

  R FOGLAR; K SHIBATA; K HORIE; A HIRASAWA; G TSUJIMOTO

  EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, Jan. 1995, Peer-reviewed

  
• EVIDENCE FOR THE EXISTENCE OF VASOPRESSIN V2 RECEPTOR MESSENGER-RNA IN RAT HIPPOCAMPUS

  A HIRASAWA; Y NAKAYAMA; N ISHIHARADA; K HONDA; R SAITO; G TSUJIMOTO; Y TAKANO; H KAMIYA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1994, Peer-reviewed

  
• THE PHARMACOLOGICAL PROFILE OF CLONED AND STABLY EXPRESSED ALPHA(1B)-ADRENOCEPTOR IN CHO CELLS

  K HORIE; A HIRASAWA; G TSUJIMOTO

  EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, Aug. 1994, Peer-reviewed

  
• CLONING, FUNCTIONAL EXPRESSION AND TISSUE DISTRIBUTION OF HUMAN CDNA FOR THE VASCULAR-TYPE VASOPRESSIN RECEPTOR

  A HIRASAWA; K SHIBATA; K KOTOSAI; G TSUJIMOTO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 1994, Peer-reviewed

  
• DISTRIBUTION AND DEVELOPMENTAL-CHANGE OF VASOPRESSIN-V1A AND VASOPRESSIN-V2 RECEPTOR MESSENGER-RNA IN RATS

  A HIRASAWA; K HASHIMOTO; G TSUJIMOTO

  EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION, Mar. 1994, Peer-reviewed

  
• EFFECTS OF A NEW FORSKOLIN DERIVATIVE, NKH477, ON CANINE VENTRICULAR ARRHYTHMIA MODELS

  A HIRASAWA; T AWAJI; M HOSONO; A HARUNO; K HASHIMOTO

  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Dec. 1993, Peer-reviewed

  
• CLONING, FUNCTIONAL EXPRESSION AND TISSUE DISTRIBUTION OF HUMAN CDNA FOR THE ALPHA(1C)-ADRENERGIC RECEPTOR

  A HIRASAWA; K HORIE; T TANAKA; K TAKAGAKI; M MURAI; J YANO; G TSUJIMOTO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 1993, Peer-reviewed

  
• IDENTIFICATION OF ALPHA(1C)-ADRENERGIC RECEPTOR MESSENGER-RNA IN BOVINE RETINAL-PIGMENT EPITHELIUM

  K HORIE; A HIRASAWA; K MASUDA; G TSUJIMOTO

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Aug. 1993, Peer-reviewed

  
• EFFECTS OF A NEW CLASS-I ANTIARRHYTHMIC DRUG BIDISOMIDE ON CANINE VENTRICULAR ARRHYTHMIA MODELS

  ZJ WU; T AWAJI; A HIRASAWA; S MOTOMURA; K HASHIMOTO

  MOLECULAR AND CELLULAR BIOCHEMISTRY, Feb. 1993, Peer-reviewed

  
• EFFECTS OF A NEW ANTIARRHYTHMIC DRUG, SD-3212, ON CANINE VENTRICULAR ARRHYTHMIA MODELS

  A HIRASAWA; A HARUNO; T MATSUZAKI; K HASHIMOTO

  JAPANESE HEART JOURNAL, Nov. 1992, Peer-reviewed

  
• Antihypertensive effects of 2-methoxyethyl (E)-3-phenyl-2-propen-1-yl (±)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) pyridine-3,5-dicarboxylate (FRC-8653), a novel dihydropyridine derivative, in renovascular hypertensive dogs

  R. Yoshimoto; A. Hirasawa; H. Dohmoto; S. Iwata

  Pharmacometrics, 1992, Peer-reviewed

  
• EFFECTS OF A NEW CLASS-III ANTIARRHYTHMIC DRUG (E-4031) ON CANINE VENTRICULAR ARRHYTHMIA MODELS

  K HASHIMOTO; A HARUNO; T MATSUZAKI; A HIRASAWA; T AWAJI; Y UEMURA

  ASIA PACIFIC JOURNAL OF PHARMACOLOGY, Jun. 1991, Peer-reviewed

  
• EFFECTS OF A NEW ANTIARRHYTHMIC DRUG TYB-3823 ON CANINE VENTRICULAR ARRHYTHMIA MODELS

  K HASHIMOTO; A SUGIYAMA; A HARUNO; T MATSUZAKI; A HIRASAWA

  JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, Feb. 1991, Peer-reviewed

  

Misc.

• NASH進行過程における長鎖脂肪酸受容体GPR120/FFA4シグナルの関与

  宮城景; 中本賀寿夫; 原田慎一; 小畑友紀雄; 森本泰子; 金啓二; 金守良; 平澤明; 徳山尚吾

  日本薬理学会近畿部会プログラム・要旨集, 2015

  
• The alteration of insaturated fatty acid receptors of type-omega-3 GPR120 leads to obesity in Men and Mice

  A. Bonnefond; O. Poulain-Godefroy; A. Ichimura; A. Hirasawa; L. Yengo; A. Leloire; H. Choquet; D. Meyre; F. Pattou; I. Wolowczuk; G. Tsujimoto; P. Froguel

  DIABETES & METABOLISM, Mar. 2012

  
• 3重結合を有する脂肪酸6-ODA・9-ODAによるFFA1依存的インスリン分泌促進効果

  西野勝俊; 上杉晴香; 平澤明; MOHAMED Neffati; 宮前友策; 増田誠司; 神戸大朋; 礒田博子; 入江一浩; 永尾雅哉

  日本農芸化学会大会講演要旨集(Web), 2019

  
• ニガハッカ(Marrubium vulgare L.)からのPPARγアゴニスト活性物質の探索

  大寺杏奈; 宮前友策; 仲井奈緒美; 荒川武明; 平澤明; 河内敦; 川田清和; HAN Junkyu; 礒田博子; MOHAMED Neffati; 前嶋一宏; 秋田徹; 森直樹; 入江一浩; 神戸大朋; 増田誠司; 永尾雅哉

  日本農芸化学会大会講演要旨集(Web), 2013

  
• 長鎖脂肪酸受容体GPR40/FFAR1の欠損は,情動行動異常を示す

  中本賀寿夫; 大垣圭弘; 相澤風花; 山下琢矢; 平澤明; 栗原崇; 宮田篤郎; 徳山尚吾

  日本神経精神薬理学会プログラム・抄録集, Sep. 2017

  
• リポポリサッカライドにより惹起される脂肪細胞炎症におけるGPR120/FFAR4シグナルの関与

  中本賀寿夫; 島田幸季; 原田慎一; 森本泰子; 平澤明; 徳山尚吾

  日本薬学会年会要旨集(CD-ROM), Mar. 2017

  
• 長鎖脂肪酸受容体GPR40/FFAR1欠損雌性マウスにおける情動および母性行動

  相澤風花; 西中崇; 大垣圭弘; 中本賀寿夫; 平澤明; 栗原崇; 宮田篤郎; 徳山尚吾

  日本神経精神薬理学会プログラム・抄録集, Jul. 2016

  
• 長鎖脂肪酸受容体GPR40/FFAR1の欠損は痛みを増強する

  中本賀寿夫; 相澤風花; 西中崇; 京谷奈月; 山下琢矢; 万倉三正; 小山豊; 糟谷史代; 平澤明; 栗原崇; 宮田篤郎; 徳山尚吾

  日本神経精神薬理学会プログラム・抄録集, Jul. 2016

  
• NASHの病態進行における長鎖脂肪酸受容体GPR120/FFAR4の関与

  宮城景; 中本賀寿夫; 小畑友紀雄; 原田慎一; 森本泰子; 平澤明; 金啓二; 金守良; 徳山尚吾

  日本薬学会年会要旨集(CD-ROM), Mar. 2016

  
• 我が国における非アルコール性脂肪性肝疾患(NAFLD)の現状と将来展望 臨床・基礎研究から薬物治療および薬剤師活動へのフィードバック NAFLD/NASH発症におけるn-3系多価不飽和脂肪酸の関与と将来展望

  中本 賀寿夫; 小畑 友紀雄; 平澤 明; 金 啓二; 金 守良; 徳山 尚吾

  日本薬学会年会要旨集, Mar. 2015

  
• Functional Characterization of Kisspeptin Receptor Ligands : Activation of Neuropeptide FF Receptors

  MISU Ryosuke; OISHI Shinya; TOMITA Kenji; SETSUDA Shohei; MASUDA Ryo; OHNO Hiroaki; NANIWA Yousuke; IEDA Nahoko; INOUE Naoko; OHKURA Satoshi; UENOYAMA Yoshihisa; TSUKAMURA Hiroko; MAEDA Kei-ichiro; HIRASAWA Akira; TSUJIMOTO Gozoh; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Transcriptome analysis on glucocorticoid-induced apoptosis in leukemia cells

  YAMADA Masateru; HIRASAWA Akira; SHIOJIMA Satoshi; TSUJIMOTO Gozoh

  応用薬理, 30 Jul. 2004

  
• SII-5. 交感神経α1-アドレナリン受容体の細胞内局在と薬理作用 (<シンポジウム II>薬物受容体・情報伝達の分子機構と分子治療学)

  辻本 豪三; 平澤 明; 許 昭俊

  Journal of smooth muscle research. Japanese section, 30 Apr. 1999

  
• Free fatty acid receptor GPR120 is highly expressed in enteroendocrine K cells of upper small intestine and has a critical role in GIP secretion ater fat ingestion

  K. Iwasaki; N. Harada; K. Sasaki; S. Yamane; K. Iida; K. Suzuki; A. Hamasaki; E. Joo; D. Nasteska; K. Shibue; T. Harada; A. Hirasawa; N. Inagaki

  DIABETOLOGIA, Sep. 2014

  
• Introduction and the future prospects of TIIMS(1)Functional genomic study for free fatty acid receptors and drug discovery

  Hirasawa Akira; Tsujimoto Gozoh

  Journal of Tokyo Women's Medical College, 25 Jun. 2011

  
• Role of free fatty acid receptor GPR120 in skin

  平澤 明

  Cosmetology : Annual report of cosmetology, 2012

  
• 長鎖脂肪酸受容体GPR120とGPR40は異なる機序で脂肪摂取時のGIP分泌に関与する

  三小田 亜希子; 原田 範雄; 岩崎 可南子; 山根 俊介; 村田 由貴; 金丸 良徳; 鈴木 和代; 渋江 公尊; 原田 貴成; 城尾 恵里奈; 平澤 明; 稲垣 暢也

  糖尿病, Apr. 2017

  
• 長鎖脂肪酸受容体GPR120とGPR40は異なる機序で脂肪摂取時のGIP分泌に関与する

  三小田亜希子; 原田範雄; 岩崎可南子; 山根俊介; 村田由貴; 金丸良徳; 鈴木和代; 渋江公尊; 原田貴成; 城尾恵里奈; 平澤明; 稲垣暢也

  糖尿病(Web), 2017

  
• GPR120/FFAR4 activation by fatty acid 16:4(n-3) plays a key role in resistance to chemotherapy

  Julia Houthuijzen; Ilse Oosterom; Brian Hudson; Akira Hirasawa; Laura Daenen; Chelsea McLean; Steffen Hansen; Marijn van Jaarsveld; Daniel Peeper; Sahar Jafari Sadatmand; Jeanine Roodhart; Chris van de Lest; Trond Ulven; Kenji Ishihara; Graeme Milligan; Emile Voest

  CANCER RESEARCH, Jul. 2016

  
• The dysfunction of brain free fatty acid receptor GPR40/FFAR1 signaling relate to the development of chronic pain

  Kazuo Nakamoto; Fuka Aizawa; Akira Hirasawa; Fumiyo Kasuya; Yutaka Koyama; Takashi Kurihara; Mitsumasa Mankura; Atsuro Miyata; Takashi Nishinaka; Shogo Tokuyama; Takuya Yamashita

  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2016

  
• The changes of emotional behavior in a free fatty acid receptor 1, GPR40/FFAR1, deficient mice

  Fuka Aizawa; Akira Hirasawa; Takashi Kurihara; Atsuro Miyata; Kazuo Nakamoto; Takashi Nishinaka; Shogo Tokuyama

  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Jun. 2016

  
• A Future Perspective on the Involvement of n-3 Polyunsaturated Fatty Acid in the Development of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

  Kazuo Nakamoto; Tokio Obata; Akira Hirasawa; Ke Ih Kim; Soo Ryang Kim; Shogo Tokuyama

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Apr. 2016

  
• Free fatty acid receptor family: A new therapeutic target for metabolic diseases

  Akira Hirasawa

  Yakugaku Zasshi, 01 Jun. 2015

  
• 脂肪酸受容体GPR120は上部小腸K細胞に高発現し脂肪摂取後のGIP分泌に深く関与する.

  原田 範雄; 岩崎 可南子; 佐々木 香月; 山根 俊介; 飯田 桂子; 濱崎 暁洋; 鈴木 和代; 城尾 恵里奈; ナステスカダニエラ; 渋江 公尊; 原田 貴成; 平澤 明; 稲垣 暢也

  Feb. 2015, Peer-reviewed

  
• Role of free fatty acid receptors in the regulation of energy metabolism

  Takafumi Hara; Daiji Kashihara; Atsuhiko Ichimura; Ikuo Kimura; Gozoh Tsujimoto; Akira Hirasawa

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Sep. 2014

  
• Fatty acid receptors as a therapeutic target for metabolic syndrome

  Akira Hirasawa; Masato Takeuchi; Ryouhei Shirai; Zao Chen; Shota Ishii; Keiko Iida

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• 金触媒を用いた三成分環化反応によるジヒドロピラゾールの合成とCK2阻害剤開発への応用

  ONO HIROAKI; SUZUKI YAMATO; HOU ZENGYE; KURE TATSUHIDE; NAKANISHI ISAO; HIRASAWA AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA

  複素環化学討論会講演要旨集, 01 Oct. 2013

  
• ニガハッカ由来不飽和脂肪酸のPPARγ及びGPR40に対するデュアルアゴニスト活性

  大寺杏奈; 宮前友策; 仲井奈緒美; 荒川武明; 平澤明; 河内敦; 川田清和; 韓畯奎; 礒田博子; Mohamed Neffati; 前嶋一宏; 秋田徹; 森直樹; 入江一浩; 神戸大朋; 増田誠司; 永尾雅哉

  新規素材探索研究会, Jun. 2013

  
• Phosphorylation and internalization of short splicing variant of the omega 3 fatty acid sensor, GPR120

  Omar Benoni Sanchez-Reyes; Jean A. Castillo-Badillo; M. Teresa Romero-Avila; Yoshinori Takei; Akira Hirasawa; Gozoh Tsujimoto; Rafael Villalobos-Molina; J. Adolfo Garcia-Sainz

  FASEB JOURNAL, Apr. 2013

  
• Exploring the chemical space of GPR40 and GPR120 with small molecules

  Hugo Tremblay; Takafumi Hara; Akira Hirasawa; Gozoh Tsujimoto; Eric Marsault

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2013

  
• Physiological functions of fatty acid receptors and their therapeutic potential

  HARA Takafumi; HIRASAWA Akira; ICHIMURA Atsuhiko; KIMURA Ikuo; TSUJIMOTO Gozoh

  Folia Pharmacologica Japonica, Dec. 2012

  
• 非経験的フラグメント分子軌道法を活用した高活性Protein Kinase CK2阻害剤の設計

  GO RYUEI; KO ZOYO; KINOSHITA TAKAYOSHI; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; SUZUKI YAMATO; NAKAMURA SHIN'YA; ONO HIROAKI; MURATA KATSUMI; KITAURA KAZUO; HIRASAWA AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NAKANISHI ISAO

  構造活性相関シンポジウム講演要旨集, 12 Nov. 2012

  
• 縮環型含窒素複素環の多様性指向型合成反応の開発とCK2阻害剤の構造活性相関研究への応用

  NAOE SAORI; SUZUKI YAMATO; OISHI SHIN'YA; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; HOU ZENGYE; KURE TATSUHIDE; NAKANISHI ISAO; ONO HIROAKI; HIRASAWA AKIRA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2012

  
• フェニルアゾール骨格を有する新規プロテインキナーゼCK2阻害剤の開発

  HOU ZENGYE; OISHI SHIN'YA; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; SUZUKI YAMATO; MURATA KATSUMI; KITAURA KAZUO; HIRASAWA AKIRA; TSUJIMOTO GOZO; ONO HIROAKI; NAKANISHI ISAO; NAKAMURA SHIN'YA; KURE TATSUHIDE; KINOSHITA TAKAYOSHI; FUJII NOBUTAKA

  複素環化学討論会講演要旨集, 30 Sep. 2012

  
• The study of the ligand-dependent signal transduction pathway and its molecular mechanism of GPR120

  T. Hara; A. Hirasawa; R. Shirai; T. Arakawa; C. Zao; I. Kimura; G. Tsujimoto

  FEBS JOURNAL, Sep. 2012

  
• アザインドール骨格またはフェニルアゾール骨格を有する新規プロテインキナーゼCK2阻害剤の開発研究

  HOU Z; OISHI SHIN'YA; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; SUZUKI YAMATO; MURATA KATSUMI; KITAURA KAZUO; HIRASAWA AKIRA; TSUJIMOTO GOZO; ONO HIROAKI; FUJII NOBUTAKA; NAKANISHI ISAO; NAKAMURA SHIN'YA; KURE RYUEI; KINOSHITA TAKAYOSHI

  次世代を担う有機化学シンポジウム講演要旨集, 11 May 2012

  
• Structure-activity relationships of free fatty acid receptors GPR40 and GPR120 agonists based on a docking simulation

  Takafumi Hara; Akira Hirasawa; Masato Takeuchi; Kumiko Ayukawa; Ryohei Shirai; Ikuo Kimura; Takayoshi Suzuki; Naoki Miyata; Gozoh Tsujimoto

  FASEB JOURNAL, Apr. 2012

  
• Short-chain fatty acids activate sympathetic neurons via a novel signaling pathway

  Daisuke Inoue; Ikuo Kimura; Kentaro Ozawa; Yosinori Takei; Akira Hirasawa; Gozoh Tsujimoto

  FASEB JOURNAL, Apr. 2012

  
• （シンポジウム「統合医科学研究所(TIIMS)の紹介と今後の展望」）ゲノム研究にもとづく脂肪酸受容体の機能解析

  平澤 明

  東京女子医科大学雑誌, 25 Aug. 2011

  
• Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

  Ikuo Kimura; Daisuke Inoue; Takeshi Maeda; Takafumi Hara; Atsuhiko Ichimura; Satoshi Miyauchi; Makio Kobayashi; Akira Hirasawa; Gozoh Tsujimoto

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2011, Peer-reviewed

  Access this misc :

  
• GPR54リガンドによるNPFF受容体の活性化

  MISU RYOSUKE; OISHI SHIN'YA; TOMITA KENJI; SETSUDA SHOHEI; MASUDA RYO; ONO HIROAKI; NAMBA YOSUKE; IEDA NAHOKO; INOUE NAOKO; OKURA SATOSHI; UENOYAMA YOSHIHISA; TSUKAMURA HIROKO; MAEDA KEIICHIRO; HIRASAWA AKIRA; TSUJIMOTO GOZO; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 栄養素センサー研究の新展開 長寿健康社会のための栄養薬学(Nutritional Pharmacy) 消化管脂肪酸受容体の生理作用

  平澤 明; 原 貴史; 市村 敦彦; 宮内 諭; 辻本 豪三

  日本薬学会年会要旨集, Mar. 2011

  
• Structure-activity relationships of GPR40 agonists based on a docking simulation

  Masato Takeuchi; Qi Sun; Takahumi Hara; Akira Hirasawa; Masaji Ishiguro; Takayoshi Suzuki; Naoki Miyata; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

  
• Synthesis and Application of Fluorescent SDF-1 Derivatives

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Yoshiaki Yano; Katsumi Matsuzaki; Nobutaka Fujii

  BIOPOLYMERS, 2011

  
• Application of fluorescent imaging technology to GPCR ligand screening

  Akira Hirasawa; Takeo Awaji; Takafumi Hara; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

  
• 連続的多成分カップリング―環化反応によるピロロインドール及びジピロロピリジン誘導体の効率的合成法の開発

  SUZUKI YAMATO; HOU ZENGYE; YASUE MISATO; HIRASAWA AKIRA; TSUJIMOTO GOZO; OISHI SHIN'YA; ONO HIROAKI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• GPR54受容体リガンドによるNPFF受容体の活性化

  SETSUDA SHOHEI; OISHI SHIN'YA; MISU RYOSUKE; TOMITA KENJI; MASUDA RYO; ONO HIROAKI; NANIWA YOSUKE; IEDA NAHOKO; INOUE NAOKO; OKURA SATOSHI; UENOYAMA YOSHIHISA; TSUKAMURA HIROKO; MAEDA KEIICHIRO; HIRASAWA AKIRA; TSUJIMOTO GOZO; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• 蛍光標識CXCR4受容体リガンドの創製と応用

  MASUDA RYO; OISHI SHIN'YA; TANAHARA NORIKO; ONO HIROAKI; HIRASAWA AKIRA; TSUJIMOTO GOZO; YANO YOSHIAKI; MATSUZAKI KATSUMI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• アザインドール骨格を有する新規CK2阻害剤テンプレートの開発研究

  HOU ZENGYE; SUZUKI YAMATO; YASUE MISATO; HIRASAWA AKIRA; TSUJIMOTO GOZO; OISHI SHIN'YA; ONO HIROAKI; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 12 Oct. 2010

  
• 脂肪酸受容体 メタボリックシンドロームと循環器系疾患

  木村 郁夫; 井上 大輔; 前田 岳志; 宮内 諭; 市村 敦彦; 平澤 明; 辻本 豪三

  血管, Oct. 2010

  
• Free fatty acid receptors and drug discovery

  平澤 明; 辻本 豪三

  医学のあゆみ, 29 May 2010

  
• Free fatty acid receptor in the gastrointestinal tract

  HIRASAWA Akira; TSUJIMOTO Gozoh

  消化と吸収, 30 Mar. 2010

  
• Novel function of long-chain free fatty acid receptor GPR120

  Gozoh Tsujimoto; Akira Hirasawa; Atsuhiko Ichimura

  ENDOCRINE JOURNAL, Mar. 2010

  
• Role of free fatty acid receptor GPR120 in metabolic regulation

  Akira Hirasawa; Takafumi Hara; Atsuhiko Ichimura; Satoshi Miyauchi; Ikuo Kimura; Koshimizu Taka-aki; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

  
• Free fatty acid receptor GPR120 and GLP-1 secretion

  平澤 明

  ホルモンと臨床, Jan. 2010

  
• Fat Sensing in the Gut

  Akira Hirasawa; Gozoh Tsujimoto

  CHEMICAL SENSES, Mar. 2009

  
• Fat sensing in the gut

  Akira Hirasawa; Takafumi Hara; Atsuhiko Ichimura; Ning Liu; Keiko Iida; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

  
• Free fatty acid receptors and their pathophysiological role in metabolic disorder

  Akira Hirasawa; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

  
• Free fatty acids receptor

  HIRASAWA Akira; TSUJIMOTO Gozoh

  Folia pharmacologica Japonica, 01 Dec. 2008

  
• ピラジンを母核とするCK2阻害剤の構造活性相関研究

  SUZUKI HIROKAZU; CLUZEAU JEROME; OISHI SHIN'YA; ONO HIROAKI; FUJII NOBUTAKA; HARA TAKASHI; HIRASAWA AKIRA; TSUJIMOTO GOZO

  日本薬学会年会要旨集, 05 Mar. 2008

  
• CXCR4受容体アンタゴニストの蛍光標識体の合成と応用

  MASUDA AKIRA; OISHI SHIN'YA; UEDA SATOSHI; EVANS BARRY; PEIPER STEPHEN C; HIRASAWA AKIRA; TSUJIMOTO GOZO; ONO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2008

  
• Synthesis and Application of Novel Fluorescence-Labeled CXCR4 Antagonists

  MASUDA Ryo; OISHI Shinya; UEDA Satoshi; GOTO Yukiko; OHNO Hiroaki; EVANS Barry; PEIPER Stephen C.; HIRASAWA Akira; TSUJIMOTO Gozoh; KODAMA Eiichi; MATSUOKA Masao; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2008

  
• Functional analysis of GPR40 using human monocytic THP-1

  Chisato Itsubo; Akira Hirasawa; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008

  
• Flow cytometer analysis of the direct interaction between GPR40 and its ligands

  Takafumi Hara; Akira Hirasawa; Chisato Itsubo; Keiko Sadakane; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008

  
• GPCR新規リガンドのIn silico探索手法の開発

  奥野恭史; 種石慶; 原貴史; 藪内弘昭; 平澤明; 辻本豪三

  血管, 31 Jan. 2007

  
• Ligand identification and functional analysis for fatty acid receptors

  Akira Hirasawa; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007

  
• Preparation of monoclonal antibody against GPR40 and immunological analysis

  Chisato Itsubo; Akira Hirasawa; Shingo Shinagawa; Hiroshi Nose; Gozoh Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007

  
• 公共マイクロアレイデータベースを用いたマウス嗅覚受容体のIn Silico発現分布

  市村敦彦; 門脇正史; 研谷佳代; 生川佳代; 平澤明; 辻本豪三

  日本薬理学雑誌, Aug. 2006

  
• BODIPY-labeled free fatty acid: a fluorescent probe for studying free fatty acid-sensitive cell surface receptor

  Shinichi Fukunaga; Akira Hirasawa; Gozoh Tsujimoto

  ACTA PHARMACOLOGICA SINICA, Jul. 2006

  
• Ligand identification and functional analysis for orphan GPCR GPR120

  A Hirasawa; G Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006

  
• In silicoリガンド予測法によるGPCR新規リガンドの探索とその評価

  原貴史; 奥野恭史; 藪内弘昭; 平澤明; 辻本豪三

  日本循環薬理学会口演要旨集, 2006

  
• Inhibition of protein kinase CK2 prevents the progression of glomerulonephritis

  M Yamada; S Katsuma; T Adachi; A Hirasawa; S Shiojima; T Kadowaki; Y Okuno; TA Koshimizu; S Fujii; Y Sekiya; Y Miyamoto; M Tamura; W Yumura; H Nihei; M Kobayashi; G Tsujimoto

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2005, Peer-reviewed

  
• cDNA cloning and characterization of rat GPR120

  T Yano; S Katsuma; A Hirasawa; G Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005

  
• Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

  A Hirasawa; K Tsumaya; T Awaji; S Katsuma; T Adachi; M Yamada; Y Sugimoto; S Miyazaki; G Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2005

  
• Recent advances in alpha(1)-adrenoceptor pharmacology (vol 98, pg 235, 2003)

  T Koshimizu; A Tanoue; A Hirasawa; J Yamauchi; G Tsujimoto

  PHARMACOLOGY & THERAPEUTICS, Jun. 2004

  
• 長鎖遊離脂肪酸によるマウス腸管由来STC-1細胞のアポトーシス阻害作用

  勝間進; 波多江典之; 類家慶直; 平沢明; 辻本豪三

  日本分子生物学会年会プログラム・講演要旨集, 2004

  
• Novel drug discovery based on genome informatics

  G Tsujimoto; A Hirasawa; S Shiojima; M Kadowaki; N Hatae; S Katsuma

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004

  
• Subtype-specific differences in subcellular localization of alpha1-adrenergic receptors

  A Hirasawa; T Awaji; K Tsumaya; S Fukunaga; T Tanaka; S Miyazaki; G Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004

  
• 'Hit-picking-out (HPO)': A rapid selection of probes for cDNA microarray.

  A Yamashita; S Shiojima; S Katsuma; A Hirasawa; T Tanaka; E Nakashima; G Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003

  
• A functional genomic approach to discover novel drug targets.

  G Tsujimoto; A Hirasawa; S Shiojima; S Katsuma; M Yamada; A Tanoue

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003

  
• Temporal expression analysis of gene expression profiling in a guinea-pig allergen-induced bronchial asthma (AIBA).

  S Shiojima; H Tanaka; A Yamashita; T Kadowaki; A Hirasawa; S Katsuma; M Yamada; T Tanaka; H Nagai; G Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003

  
• Establishment of ligand assay system using a receptor internalization.

  K Tsumaya; A Hirasawa; G Tsujimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003

  
• 基礎から臨床へ α1アドレナリン受容体の分子生物学

  平澤 明; 辻本 豪三

  診断と治療, Jul. 2002

  
• 心血管系におけるα1アドレナリン受容体 : 最近の知見

  輿水 崇鏡; 田上 昭人; 山内 淳司; 平澤 明; 辻本 豪三

  血管, 19 May 2002

  
• Gene expression profiling of a guinea-pig model of allergen-induced bronchial asthma (AIBA).

  S Shiojima; H Tanaka; A Hirasawa; S Katsuma; A Yamashita; M Yamada; H Ikawa; T Tanaka; H Nagai; G Tsujimoto

  FASEB JOURNAL, Mar. 2002

  
• Gene expression profiling of a guinea-pig model of allergen-induced bronchial asthma (AIBA)

  S Shiojima; H Tanaka; A Hirasawa; S Katsuma; A Yamashita; M Yamada; H Ikawa; T Tanaka; H Nagai; G Tsujimoto

  JAPANESE JOURNAL OF PHARMACOLOGY, 2002

  
• Glucocorticoid-regulated genes involved in apoptosis of human leukemia cells

  M Yamada; A Hirasawa; S Katsuma; S Shiojima; H Ikawa; A Yamashita; T Miyashita; G Tsujimoto

  JAPANESE JOURNAL OF PHARMACOLOGY, 2002

  
• Sequential expression of specific genes during early pregnancy of somatic-cell clone-recipient cows.

  K Kizaki; H Ishiwata; A Hirasawa; S Shiojima; S Katsuma; H Ikawa; K Imai; T Takahashi; S Takahashi; S Akagi; G Tsujimoto; K Hashizume

  BIOLOGY OF REPRODUCTION, 2002

  
• Gene expression profiling of a rat model of liver regeneration

  A Hirasawa; Y Fukuhara; S Katsuma; M Yamada; S Shiojima; A Yamashita; H Ikawa; XK Lia; S Suzuki; G Tsujimoto

  JAPANESE JOURNAL OF PHARMACOLOGY, 2002

  
• Characterization of inducible genes in gestating bovine uterus employing cDNA microarray.

  H Ishiwata; K Kizaki; H Nakano; T Takahashi; K Imai; A Hirasawa; S Shiojima; S Katsuma; Y Suzuki; K Ikawa; G Tsujimoto; K Hashizume

  BIOLOGY OF REPRODUCTION, 2001

  
• アドレナリン受容体の多型と薬物反応の個人差 (新世紀医療をめざして(5)Pharmacogenomics)

  平澤 明; 辻本 豪三

  遺伝子医学, 2001

  
• 新しい創薬 分子デザイン創薬 (12月第5土曜特集 21世紀に期待される医学・医療) -- (第4章 薬)

  平澤 明; 辻本 豪三

  医学のあゆみ, 30 Dec. 2000

  
• Key amino acids of vasopressin Via receptor responsible for the species difference in the affinity of OPC-21268 (FEBS 23227) (vol 466, pg 255, 2000)

  H Shinoura; H Take; S Itoh; A Hirasawa; K Inoue; Y Ohno; K Hashimoto; G Tsujimoto

  FEBS LETTERS, Jun. 2000

  
• 受容体タンパク質の細胞内輸送におけるソーティング (特集 細胞内輸送)

  平澤 明; 辻本 豪三

  生体の科学, Dec. 1999

  
• マイクロアレイ研究支援情報:ラボオートメーション,マイクロアレイ研究会と各種Web情報 (DNAチップワークショップ講演要旨)

  平澤 明; 辻本 豪三

  動物遺伝研究会誌, Oct. 1999

  
• Interaction of α1b-adrenergic receptor with gC1qR, a binding protein for globular heads of complement C1q

  XU Zhaojun; HIRASAWA Akira; TSUJIMOTO Gozoh

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• アドレナリン受容体 (受容体 1997) -- (Gタンパク質共役型受容体--神経伝達物質・ホルモン)

  平沢 明; 辻本 豪三

  生体の科学, Oct. 1997

  
• 共焦点顕微鏡によるGFP融合α1受容体のinternalizationの解析

  淡路 健雄; 片岡 正和; 平澤 明; 辻本 豪三

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• 2型バゾプレッシンレセプターのラット脳内局在について

  加藤 陽一郎; 五十嵐 紀子; 平澤 明; 辻本 豪三; 小林 槇雄

  東京女子医科大学雑誌, 25 Jun. 1995

  
• VACCINATION WITH A SYNTHETIC T-CELL RECEPTOR V-REGION PEPTIDE - IMMUNOMODULATION OR VACCINATION

  H KANEKO; K IIZUKA; Y KOKAI; JI FUJIMOTO; A HIRASAWA; G TSUJIMOTO; H KOIKE; N TORRESNAGEL; T HUNIG; H KIMURA

  TRANSPLANTATION PROCEEDINGS, Apr. 1995, Peer-reviewed

  
• POLYMERASE CHAIN-REACTION OF THE RAT SEX-DETERMINING REGION OF THE Y-CHROMOSOME AND ITS APPLICATION TO ESTIMATING A STATE OF SENSITIZATION TO MINOR HISTOCOMPATIBILITY ANTIGEN H-Y

  A HIRASAWA; G TSUJIMOTO; S OKUYAMA; XK LI; M IWAYA; Y MASAKI; Y YOKOI; S NAKAMURA; S BABA; M MIYAMOTO; H AMEMIYA; H KIMURA

  TRANSPLANTATION PROCEEDINGS, Apr. 1995, Peer-reviewed

  
• CLONING OF THE HUMAN ALPHA(10)-ADRENERGIC RECEPTOR (AR) AND INDUCIBLE EXPRESSION OF 3 HUMAN SUBTYPES IN SKNMC CELLS

  TA ESBENSHADE; A HIRASAWA; G TSUJIMOTO; T TANAKA; J YANO; KP MINNEMAN; TJ MURPHY

  FASEB JOURNAL, Mar. 1995

  
• MICROCHIMERISM AND HEART ALLOGRAFT ACCEPTANCE

  Y MASAKI; A HIRASAWA; S OKUYAMA; G TSUJIMOTO; M IWAYA; XK LI; Y YOKOI; S NAKAMURA; S BABA; M MIYAMOTO; M HARA; K SHIBATA; Y KOGA; H AMEMIYA; H KIMURA

  TRANSPLANTATION PROCEEDINGS, Feb. 1995, Peer-reviewed

  
• PHARMACOLOGICAL CHARACTERISTICS OF ALPHA-1-ADRENERGIC RECEPTORS IN BOVINE RETINAL-PIGMENT EPITHELIUM

  K HORIE; A HIRASAWA; G TSUJIMOTO

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Mar. 1994

  
• DEXAMETHASONE INDUCES TRANSCRIPTION AND EXPRESSION OF ANGIOTENSIN-II TYPE-1 RECEPTOR GENE IN VASCULAR SMOOTH-MUSCLE CELLS

  A SATO; H SUZUKI; M MURAKAMI; G TSUJIMOTO; A HIRASAWA; Y IWAITA; Y NAKAZATO; T SARUTA

  HYPERTENSION, Sep. 1992

  

Presentations

• Free fatty acid receptor GPR120, physiology and drug discovery

  HIRASAWA Akira

  Awaji-Symposium on RNA & CLOCK, 25 Mar. 2015

  
• マイクロアレイを用いたアミロイドβタンパク質による細胞死メカニズムの考察

  平澤 明

  第 36 回生体膜と薬物の相互作用シンポジウム, 20 Nov. 2014

  
• Free fatty acid receptor family: new therapeutic target for metabolic diseases

  HIRASAWA Akira

  日本薬学会第134回年会, 28 Mar. 2014

  
• Fatty acid receptors as a therapeutic target for metabolic syndrome

  HIRASAWA Akira

  第87回日本薬理学会年会, 21 Mar. 2014

  
• 脂肪酸受容体GPR120の生理機能の解明と創薬

  HIRASAWA Akira

  DM Seminar in HIROSHIMA, 12 Dec. 2013

  
• 脂肪酸受容体GPR120の生理機能の解明と創薬

  HIRASAWA Akira

  第7回最新動脈硬化フォーラム, 08 Nov. 2013

  
• Free fatty acid receptor GPR120, physiology and drug discovery

  HIRASAWA Akira

  第５回食品薬学シンポジウム, 02 Nov. 2013

  
• Free fatty acid receptor GPR120, physiology and drug discovery

  HIRASAWA Akira

  第36回内藤コンファレンス, 11 Sep. 2013

  
• 脂肪酸受容体GPR120の発見と生理機能の解明

  平澤 明

  京都炎症・代謝疾患研究会, 05 Sep. 2013, Invited

  
• 脂肪酸受容体GPR120の発見と生理機能の解明

  平澤 明

  MEET THE EXPERT（東大循環器内科招待講演）, 13 Jul. 2013, Invited

  
• 脂肪酸受容体GPR120の発見と生理機能の解明

  平澤 明

  第18回 Osaka Bay Diabetes Forum（OBDF）, 23 Feb. 2013, Invited

  
• 脂肪酸受容体GPR120の発見と生理機能の解明

  平澤 明

  第９回宮崎サイエンスキャンプ, 17 Feb. 2013

  
• Fatty acid receptor GPR120 mediates diet-induced obesity

  HIRASAWA Akira

  第85回日本生化学会大会, 15 Dec. 2012

  

Books and Other Publications

• 脂質代謝異常と関連疾患 : 疾患モデルの作製と利用

  尾池, 雄一; 佐々木, 雄彦; 村上, 誠; 矢作, 直也, Contributor, 脂肪酸受容体

  エル・アイ・シー, 2015

  Find Kyoto University's collection of books :

  
• Bioactive lipid mediators : current reviews and protocols

  横溝, 岳彦; 村上, 誠, Contributor, Fatty acid receptors

  Springer, 2015

  Find Kyoto University's collection of books :

  
• 薬物受容体と疾患

  平澤 明, Contributor, 第２章の２. マイクロアレイによる受容体解析法

  医薬ジャーナル社, 2002, Not refereed

  
• DNAマイクロアレイデータ解析入門

  平澤 明, Contributor, 第７章 調節ネットワークのリバースエンジニアリング

  羊土社, 2002, Not refereed

  
• 薬物動態・作用と遺伝子多型：薬物治療法の患者個別化を目指した２１世紀の新展開

  平澤 明, Contributor, 第３章の４−ｄ. αアドレナリンレセプター

  医薬ジャーナル社, 2001, Not refereed

  

Industrial Property Rights

• 特許第5420400号, 特願2009-514126, Gタンパク質共役型レセプター作動剤

  辻本 豪三; 平澤 明; 宮田 直樹; 鈴木 孝禎; 高原 義之; 石黒 正路; 畑 美絵

  
• 特開2012-197239, 特願2011-061679, 腎臓内カゼインキナーゼ2阻害剤

  辻本 豪三; 平澤 明; 劉 寧; 武井 義則

  
• WO2012-121168, JP2012055451, キナーゼ阻害剤

  辻本 豪三; 平澤 明; 村田 克美; 藤井 信孝; 大野 浩章; 大石 真也; 鈴木 大和; ゾンイェ ホウ; 仲西 功; 木下 誉富; 高倉 喜信; 西川 元也

  
• 特開2012-153679, 特願2011-016446, G蛋白質共役型レセプター作動剤

  辻本 豪三; 平澤 明; 宮田 直樹; 鈴木 孝禎; 平野 達也; 高原 義之

  
• 特許第4757190号, 特願2006-510373, 血糖値の低下に供される医薬組成物

  平澤 明; 辻本 豪三

  
• 特開2010-059106, 特願2008-227107, 糖尿病進行抑制作用を有する組成物

  吉川 和子; 橋本 敏弘; 平澤 明; 辻本 豪三; 山本 恭介; 井ノ瀬 利明; 木村 隆

  
• WO2008-139987, JP2008058457, Gタンパク質共役型レセプター作動剤

  辻本 豪三; 平澤 明; 宮田 直樹; 鈴木 孝禎; 高原 義之; 石黒 正路; 畑 美絵

  
• WO2008-139879, JP2008057917, G蛋白質共役型レセプター抑制剤および医薬

  辻本 豪三; 平澤 明; 宮田 直樹; 鈴木 孝禎; 高原 義之

  
• 特開2008-195625, 特願2007-029766, Ｇ蛋白質共役型レセプター抑制剤および医薬

  辻本豪三; 平澤明; 高原 義之

  
• 特開2008-088080, 特願2006-268678, Ｇ蛋白質共役型レセプター抑制剤，医薬およびスクリーニング方法

  辻本豪三; 平澤明

  
• 特開2008-001690, 特願2007-138654, Ｇタンパク質共役型レセプターの作動剤および医薬

  辻本豪三; 平澤明

  
• WO2005-083070, JP2004012848, 血糖値の低下に供される医薬組成物

  平澤 明; 辻本 豪三

  
• 特開2005-015358, 特願2003-180375, 摂食障害の治療に供される医薬品組成物

  平澤明; 辻本豪三

  
• 特許第2961995号, 特開平5-097808, 特願平3-260838, ピペリジン誘導体およびこれを含有する抗不整脈薬

  平澤 明; 鈴木 昇; 吉元 良太; 鈴木 伸育; 兼松 章; 東海林 政孝

  
• 特許第2853404号, 特開平5-025044, 特願平3-254951, 抗不整脈薬

  平澤 明; 鈴木 昇; 吉元 良太; 東海林 政孝; 江口 新比古; 行徳 祐一

  
• 特開平5-097673, 特願平3-260837, 抗不整脈薬

  平澤 明; 鈴木 昇; 吉元 良太; 東海林 政孝

  
• 特開平5-097808, 特願平3-260838, ピペリジン誘導体およびこれを含有する抗不整脈薬

  平澤 明; 鈴木 昇; 吉元 良太; 鈴木 伸育; 兼松 章; 東海林 政孝

  
• 特開平5-025044, 特願平3-254951, 抗不整脈薬

  平澤 明; 鈴木 昇; 吉元 良太; 東海林 政孝; 江口 新比古; 行徳 祐一

  
• 特開05-025044, 抗不整脈薬

  平澤明; 鈴木昇; 吉元良太; 東海林政孝; 江口新比古; 行徳祐一

  
• 特開05-097808, ピペリジン誘導体およびこれを含有する抗不整脈薬

  平澤明; 鈴木昇; 吉元良太; 鈴木伸育; 兼松章; 東海林政孝

  
• 特願2007-116372, Gタンパク質共役型レセプター作動剤

  辻本豪三; 平澤明; 宮田直樹; 鈴木孝禎; 高原義之; 石黒正路; 畑美絵

  
• 特願特許第4757190号, 2006-510373, 血糖値の低下に供される医薬組成物

  辻本豪三; 平澤明; 株式会社ファルマデザイン

  

External funds: Kakenhi

• Analysis of sperm function mediated by polyunsaturated fatty acid receptor GPR120

  Grant-in-Aid for Scientific Research (C)

  Basic Section 56030:Urology-related

  Saitama Medical University

  Takeo Awaji

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  長鎖不飽和脂肪酸;長鎖不飽和脂肪酸受容体;精子;αリノレン酸;不飽和脂肪酸;不飽和脂肪酸受容体;GPR120;多価不飽和脂肪酸;三量体Gタンパク質共役型受容体;三量体G蛋白共役型受容体;抗体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K09148/
• The mechanism of NASH development via long chain fatty acid receptor GPR120/FFAR4.

  Grant-in-Aid for Challenging Exploratory Research

  Kobe Gakuin University

  TOKIO OBATA

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  非アルコール性脂肪性肝炎(NASH);GPR120/FFAR4;DHA;fatty acid;NASH;NAFLD;肝臓;白色脂肪組織

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K12715/
• Elucidation of physiological role of the fatty acid receptor bycomputer simulation and the fluorescent probe detection system

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Akira HIRASAWA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  分子生物学脂肪酸受容体;GPR40;GPR120;蛍光プローブ;肥満;シミュレーション;脂肪酸受容体;ドッキングシミュレーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659038/
• Physiological role of free fatty acid receptor GPR120.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Akira HIRASAWA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  薬理学;GPCR;GPR120;フローサイトメーター;ゲノム創薬科学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390021/
• 新規蛍光プローブを用いたG蛋白質共役型脂肪酸受容体ファミリー活性化機構の解析

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  平澤 明

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  分子生物学;ゲノム創薬科学;蛍光ブロープ;GPR120;フローサイトメトリー;GPCR;蛍光プローブ;脂肪酸受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20659011/
• Long chain fatty acid receptor function using visualization of mitochondrial function

  Grant-in-Aid for Scientific Research (C)

  Saitama Medical University

  Takeo AWAJI

  From 01 Apr. 2007, To 31 Mar. 2010, Project Closed

  不飽和脂肪酸受容体;Green Fluorescent Protein;生命現象可視化;細胞内カルシウムイオン濃度測定;水素イオン濃度;ミトコンドリア機能;細胞内シグナル伝達機構;三量体共役形受容体;GPR 40;GPR120;可視化解析;細胞内カルシウム濃度;GPR40

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590260/
• New genome medicine and drug discovery based on the comprehensive transcriptome analysis

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Gozoh TSUJIMOTO

  From 01 Apr. 2007, To 31 Mar. 2012, Project Closed

  包括的トランスクリプトーム解析;マイクロRNA;ネットワーク解析;超高感度DNAチップ;発現プロファイル;食道がん;乳がん;バイオマーカー;miRNA;上皮細胞;がん;分化;microRNA;トランスクリプトーム;DNAチップ;バイオインフォマッティックス;RNA;疾患動物モデル;バイオインフォマティックス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19109001/
• Regulation of peptides secretion by orphan G protein coupled receptor

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Akira HIRASAWA

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  プロテオーム;シグナル伝達;マイクロアレイ;薬学;ゲノム;オーファン受容体;脂肪酸;分泌;ペプチド;脂肪酸受容体;質量分析, Proteome;signal transduction;Microarray;pharmaceutical sciences;genome

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390024/
• 脂肪酸受容体を介する脂肪細胞機能調節機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  平澤 明

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  GPR120;脂肪酸;脂肪細胞;siRNA;分化;GLP-1;3T3-L1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18052009/
• 微量臨床検体発現プロファイルによるがんの個別化治療

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  辻本 豪三

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  個別化医療;マイクロアレイ;臨床検体;食道癌;バイオインフォマティクス;ゲノム情報;食道がん;DNAチップ;ゲノム医療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18018024/
• Identification of ligand and function of novel group of free fatty acid receptors by using genome information.

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Gozoh TSUJIMOTO

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  オーファンG蛋白共役型受容体;GPR120;腸管内分泌細胞;遊離脂肪酸;細胞内カルシウム;GLP-1(グルカゴン様ペプチド-1);GPR40ファミリー(GPR40,41,43);G蛋白質共役型受容体;GPR40;抗体;カルシウムシグナル;ERK;ノックアウトマウス;遊離脂肪酸受容体;リガンド;GLP-1, Orphan G protein-coupled;GPR120;Enteroendocrine cell;Free fatty acid;Intracellular calcium;GLP-1 (glucagon-like peptide 1);GPR 40 family (GPR40,41,43)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17209003/
• 臨床ゲノム研究のための高感度ゲノム機能解析システムの開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  辻本 豪三

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  DNAチップ;高感度化;高感度チップ;テーラーメード医療;微量臨床検体;網羅的;ゲノム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17019038/
• Relationship between subcellular localization of α-adrenoceptor subtypes and function on ischemia

  Grant-in-Aid for Scientific Research (C)

  Tokyo Women's Medical University

  Takeo AWAJI

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  pH可視化測定;α_1受容体;GFP;細胞内局在;α1受容体, α_1-adrenoceptor;green fluorescent protein;Ca^<2+> oscillations;subcellular localization;Hydrion density

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590192/
• A novel functional genomics approach and ligand hunting for orphan seven transmembrane receptors.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University;National Research Institute for Child Health and Development

  Akira HIRASAWA

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  オーファン受容体;リガンド探索;GPR120;GLP-1;腸内分泌細胞;肥満;糖尿病;GFP;データベース;細胞内局在, orphan receptor;ligand hunting;GPR120;GLP-1;enteroendocrine cells;obesity;diabetes

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590095/
• In vitro analysis of signaling pathway involved in pathgenesis of renal or cardiac disease using animal models.

  Grant-in-Aid for Scientific Research (C)

  NATIONAL RESEARCH INSTITUTE FOR CHIOLD HEALTH AND DEVELOPMENT

  Akito TANOUE

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  疾患モデル動物;薬物効果;受容体;DNAチップ;マイクロアレイ, animal models;drugs;receptors;DNA chip;micrarray

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14572173/
• 7回膜貫通型受容体の蛋白間相互作用の解析とその生理的意義

  Grant-in-Aid for Encouragement of Young Scientists (A)

  国立小児病院(小児医療研究センター)

  平澤 明

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  アドレナリン受容体;GFP;蛍光標識リカンド;internalization;細胞内局在;細胞内pH;α1Aアドレナリン受容体;α1Bアドレナリン受容体;yeast two-hybrid法;Green Fluorescent Protein;gClqBP;受容体ヘテロ二量体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12771429/
• Analysis of disease-related genes by using microaaray DNA chip with the normalized cDNA library

  Grant-in-Aid for Scientific Research (C)

  NATIONAL CHILDREN'S MEDICAL RESEARCH CENTER

  Gozoh TSUJIMOTO

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  マイクロアレイ;標準化ライブラリー;DNAチップ;IgA腎症;ブレオマイシン誘導性肺線維症;標準ライブラリー;cDNAマイクロアレイ;ブレオマイシン誘導性肺繊維症;標準化cDNAチップ;臓器別標準化ライブラリー;サブトラクト法;ヒットピッキング法;cDNAチップ, IgA nephropathy;EDG5;microarray;DNA chip;subtractive;library

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670101/
• G蛋白共役型受容体の細胞内局在の分子機構の解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  国立小児病院(小児医療研究センター)

  平澤 明

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  α1Aアドレナリン受容体;α1Bアドレナリン受容体;yeast two-hybrid法;Green Fluorescent Protein;gClqBP;Green Fluorescent protein;フローサイトメトリー;レーザー共焦点顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10771314/
• Use of G-protein-coupled receptor subtype genes for novel drug discovery

  Grant-in-Aid for Scientific Research (A)

  NATIONAL CHILDREN'S MEDICAL RESEARCH CENTER

  Gozoh TSUJIMOTO

  From 01 Apr. 1996, To 31 Mar. 1999, Project Closed

  G蛋白質共役型受容体;α1アドレナリン受容体サブタイプ;細胞内情報伝達機構;クローニング;可視化技術;共焦点顕微鏡;細胞内局在;サブタイプ受容体;a1アドレナリン受容体;Green Fluorecent Protein;創薬ストラテジー;スプライスバリアント, G-protein-coupled receptor;alpha1-adrenoceptor subtypes;cellular signal transduction mechanism;molecular cloning;visualized cell biology;conforcal microscopy;intracellular localization

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08557148/
• G蛋白質共役受容体の細胞内動態の解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  国立小児病院

  平澤 明

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  アドレナリン受容体;フローサイトメトリー;共焦点レーザー顕微鏡;リン酸化;ソーティング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07772212/
• Research on novel therapies and drugs through the elucidation of aging mechanisms

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47040:Pharmacology-related

  Kyoto University

  平澤 明

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  老化;脂肪酸受容体;発現プロファイル;マルチオミクス;GPR120

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06148/

External funds: others

• 1 Structure-Function relationship and subcellular localization of 7transmembrane receptors 2 Expression profile analysis using cDNA microarray

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  T012, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  T005, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Fundamental Chemical Experiments

  N308, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship B

  8306, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice B

  8304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Pharmacogenomics)

  D155, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacology 3 (Central Nervous System Pharmacology)

  A307, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  A303, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacology3

  C337, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology II (Pathophysiology)

  C303, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  C906, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  1028, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  8105, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  T012, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  T005, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmacogenomics)

  D155, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmacogenomics)

  B816, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmacogenomics)

  E815, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  C906, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Skill Development for Target Discovery

  5101, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  A906, Fall, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmacogenomics)

  8155, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  1028, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Clinical Pharmacy

  6001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  8105, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology 2 (Molecular Physiology)

  A302, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacology I

  C305, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology II (Pathophysiology)

  C303, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  A303, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Pharmacogenomics)

  D155, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  T005, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  A303, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  A906, Fall, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  T012, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Skill Development for Target Discovery

  5101, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Physiology II (Pathophysiology)

  C303, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  1028, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  C906, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Pharmacogenomics)

  B816, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  8105, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Pharmacogenomics)

  8155, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Technology in Life Sciences

  1106, Spring, Graduate School of Pharmaceutical Sciences, 2
• From Apr. 2011, To Mar. 2012

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Bioinformatics III: Clinical Studies

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Introduction to Genome-based

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Information Processing Basics 1

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  Information Processing Basics 2

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Pharmaceuticals and Medicine

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  薬学専門実習III

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  薬学専門実習４

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Introduction to Genome-based Drug Discovery

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Information Processing Basics 1

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Information Processing Basics 2

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Pharmaceuticals and Medicine

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory IV: Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Genome-based Drug Discovery

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Drug Discovery & Development III: Clinical Development Process

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Drug Discovery & Development III

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Basic Informatics & Practice (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Genome-based Drug Discovery

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Basic Informatics & Practice (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Introduction to Genome-based Drug Discovery

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Informatics & Practice (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Drug Discovery & Development III: Clinical Development Process

  Fall, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Pharmaceuticals and Medicine

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Introduction to Genome-based Drug Discovery

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Basic Pharmacy and Biomedicinal Sciences II

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Fundamental Chemical Experiments

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Drug Discovery & Development III: Clinical Development Process

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Basic Pharmacy and Biomedicinal Sciences II

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Physiology II (Pathophysiology)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Drug Discovery & Development III: Clinical Development Process

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Physiology II (Pathophysiology)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  ILAS Seminar :Pharmaceuticals and Medicine

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Basic Informatics (Faculty of Pharmaceutical Sciences)

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Skill Development for Target Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Pharmacogenomics)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Experimental Technology in Life Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Technology in Life Sciences

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Physiology II (Pathophysiology)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory 4 : Biochemistry and Microbiology

  Fall, 薬学部