Basic Information

Concurrent Affiliation

• Center for the Promotion of Interdisciplinary Education and Research (C-PiER)

Professional Memberships

• From Apr. 2010, To Present

  Japan Proteomics Society
• From Apr. 2007, To Present

  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
• From Apr. 2013, To Mar. 2014

  American Society for Biochemistry and Molecular Biology

Academic Degree

• 修士（政策・メディア）(慶應義塾大学)
• 博士（薬学）(京都大学)

Research History

• From Apr. 2017, To Mar. 2022

  Center for iPS cell Research and Application, Dept. of Life Science Frontiers, Assistant Professor (K-CONNEX)
• From Apr. 2016, To Mar. 2017

  Kyoto University, Center for iPS cell Research and Application, Research associate
• From Apr. 2013, To Mar. 2016

  Kyoto University, Center for iPS cell research and application, JSPS PD
• From Apr. 2011, To Mar. 2013

  Kyoto University, Pharmaceutical science, JSPS DC1
• From Apr. 2010, To Mar. 2011

  Keio University, Faculty of Environment and Information Studies, Part-time Lecturer
• From Apr. 2010, To Mar. 2011

  Keio University, 政策・メディア研究科, JSPS DC1
• From Apr. 2022, To Present

  Center for iPS Cell Research and Application, Kyoto University, Department of Life Science Frontiers, Junior Associate Professor

Profile

• Profile

  Google Scholar http://scholar.google.co.jp/citations?hl=ja&user=5gjFvZQAAAAJ

  
  

  2024年 京都大学ビジュアルブック 岩崎未央(p76) https://my.ebook5.net/kyoto-u/visual_book2024_jp/

  
  

  2022年 京都大学iPS細胞研究所　岩崎未央研究室の紹介 https://www.youtube.com/watch?v=ZBpnuDpSdiE

  
  

  2022年 現状のプロテオーム定量解析手法 -single cell解析からbulk解析まで- https://www.youtube.com/watch?v=XZ1GWyhEGfg

  
  

  2020年 福島大学うつくしまふくしま未来支援センター・CiRA共催シンポジウム https://www.youtube.com/watch?v=siEGitYZ5GI

  
  

  2017年 薬学研究へのいざない(2)　博士修了者からのメッセージ 岩崎未央 https://www.youtube.com/watch?v=LcAqWWAL2uI

ID,URL

• ORCID ID

  0000-0003-2085-732X

• J-Global ID

  201401079850021094

• External link

  https://iwasaki-lab.cira.kyoto-u.ac.jp/

researchmap URL

• https://researchmap.jp/omio

Research

Research Topics, Overview of the research

• Research Topics

  Cellular control mechanism by proteins

• Overview of the research

  Central dogma proposed in 1958 by Dr. Crick, that gene expression is performed from transcribed mRNA (from DNA) to translated protein. This is still a basic principle of molecular biology.
  However, the whole picture of what kind of control mechanism exists at each stage has not yet been elucidated. We analyze various large-scale data, identify genes whose amount of protein is specifically changing according to the cell types. We’d like to elucidate the control mechanism of amount of protein. If the regulatory mechanism of the protein that determines the identity of each cell is clarified, artificial control of cell fate could be possible. In addition, this research is important for a wide range of biology related fields such as pharmaceuticals and medical applications because we could uncover important proteins to target each cell types and to increase reprogramming efficiency.

Research Interests

• posttranscriptional regulation
• Analytical science
• Proteomics
• Bioinformatics
• Translational regulation
• Protein

Research Areas

• Life sciences, Genomics

Papers

• Meeting Report: The Japanese-German Symposium on the "Advancement and Application of Proteoform-Centric Proteomics" (Kyoto, Japan, 2024).

  Nobuaki Takemori; Philipp T Kaulich; Jan Hahn; Hartmut Schlüter; Naoyuki Sugiyama; Kazuya Tsumagari; Yasushi Ishihama; Sabine Fuchs; Mio Iwasaki; Franz-Josef Müller; Christian Neusüß; Kyowon Jeong; Oliver Kohlbacher; Yoshihiro Shimizu; Yoichi Otsuka; Hisako Sato; Kazuki Sasaki; Yuriko Minegishi; Yoshio Kodera; Irene Fernandez-Cuesta; Boris Krichel; Norie Araki; Andreas Tholey

  Proteomics, 20 May 2025

  
• Human iPSC-derived nephron progenitor cells treat acute kidney injury and chronic kidney disease in mouse models.

  Toshikazu Araoka; Kosuke Toyohara; Makoto Ryosaka; Chihiro Inui; Maasa Matsuura; Chen Ma; Jun Watahiki; Zhongwei Li; Mio Iwasaki; Akira Watanabe; Ryuji Yokokawa; Yasuhiko Tabata; Juan Carlos Izpisua Belmonte; Kenji Osafune

  Science translational medicine, 02 Apr. 2025

  
• jPOST environment accelerates the reuse and reanalysis of public proteome mass spectrometry data

  Shujiro Okuda; Akiyasu C Yoshizawa; Daiki Kobayashi; Yushi Takahashi; Yu Watanabe; Yuki Moriya; Atsushi Hatano; Tomoyo Takami; Masaki Matsumoto; Norie Araki; Tsuyoshi Tabata; Mio Iwasaki; Naoyuki Sugiyama; Yoshio Kodera; Satoshi Tanaka; Susumu Goto; Shin Kawano; Yasushi Ishihama

  Nucleic Acids Research, 11 Nov. 2024

  Access this paper :

  
• 

  Differences in Uniquely Identified Peptides Between ddaPASEF and diaPASEF

  Mio Iwasaki; Rika Nishimura; Tatsuya Yamakawa; Yousuke Miyamoto; Tsuyoshi Tabata; Megumi Narita

  Cells, 07 Nov. 2024, Peer-reviewed, Lead author, Corresponding author

  
• Non-invasive monitoring of midbrain dopaminergic progenitor cell production from human pluripotent stem cells

  Mio Iwasaki; Nicola J. Drummond; David E. McNay; Maurice A. Canham; Daniel Tikhomirov; Donia Arafa; Mariah Lelos; Asuka Morizane; Tilo Kunath

  02 Sep. 2023, Lead author

  
• Construction of multilayered small intestine-like tissue by reproducing interstitial flow.

  Sayaka Deguchi; Kaori Kosugi; Naoki Takeishi; Yukio Watanabe; Shiho Morimoto; Ryosuke Negoro; Fuki Yokoi; Hiroki Futatsusako; May Nakajima-Koyama; Mio Iwasaki; Takuya Yamamoto; Yoshiya Kawaguchi; Yu-Suke Torisawa; Kazuo Takayama

  Cell stem cell, 03 Jul. 2024

  
• デュシェンヌ型筋ジストロフィーマウスに対するトレーニングが細胞移植治療効果を促進するメカニズム解明

  三木 麻有甫; 竹中 菜々[蜷川]; 後藤 萌; 吉岡ブルジョワ クレモンス紀穂; 岩崎 未央; 青山 朋樹; 櫻井 英俊

  基礎理学療法学, Jan. 2024

  
• 

  Proteomic analysis data of human induced pluripotent stem cells and human fibroblast cells

  Mio Iwasaki; Yasushi Ishihama

  Journal of Proteome Data and Methods, Dec. 2019, Peer-reviewed, Lead author, Corresponding author

  
• 

  Biosystems Revealed by Multi-Layered Omics Technology

  Mio Iwasaki

  KEIO SFC JOURNAL, Mar. 2023, Peer-reviewed, Invited, Lead author, Corresponding author

  
• 

  pSNAP: Proteome-wide analysis of elongating nascent polypeptide chains

  Junki Uchiyama; Rohini Roy; Dan Ohtan Wang; Kazuya Morikawa; Yuka Kawahara; Mio Iwasaki; Chiaki Yoshino; Yuichiro Mishima; Yasushi Ishihama; Koshi Imami

  iScience, Jun. 2022, Peer-reviewed

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• 

  A stress-reduced passaging technique improves the viability of human pluripotent cells.

  Kazutoshi Takahashi; Chikako Okubo; Michiko Nakamura; Mio Iwasaki; Yuka Kawahara; Tsuyoshi Tabata; Yousuke Miyamoto; Knut Woltjen; Shinya Yamanaka

  Cell reports methods, 28 Feb. 2022, Peer-reviewed

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• 

  Multi-omics approach reveals post-transcriptionally regulated genes are essential for human pluripotent stem cells

  Mio Iwasaki; Yuka Kawahara; Chikako Okubo; Tatsuya Yamakawa; Michiko Nakamura; Tsuyoshi Tabata; Yohei Nishi; Megumi Narita; Akira Ohta; Hirohide Saito; Takuya Yamamoto; Masato Nakagawa; Shinya Yamanaka; Kazutoshi Takahashi

  iScience, Apr. 2022, Peer-reviewed, Lead author, Corresponding author

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• 

  MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains.

  Chiaki Akifuji; Mio Iwasaki; Yuka Kawahara; Chiho Sakurai; Yu-Shen Cheng; Takahiko Imai; Masato Nakagawa

  Scientific reports, 20 Dec. 2021, Peer-reviewed

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• 

  Grafting of iPS cell-derived tenocytes promotes motor function recovery after Achilles tendon rupture.

  Taiki Nakajima; Akihiro Nakahata; Naoki Yamada; Keiko Yoshizawa; Tomoaki M Kato; Mio Iwasaki; Chengzhu Zhao; Hiroshi Kuroki; Makoto Ikeya

  Nature communications, 18 Aug. 2021, Peer-reviewed

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• Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells.

  Azuma Kimura; Taro Toyoda; Mio Iwasaki; Ryusuke Hirama; Kenji Osafune

  Cell chemical biology, 16 Sep. 2020, Peer-reviewed

  
• 

  Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.

  Kazutoshi Takahashi; Daeun Jeong; Songnan Wang; Megumi Narita; Xuemei Jin; Mio Iwasaki; Samuel D Perli; Bruce R Conklin; Shinya Yamanaka

  Cell reports, 02 Jun. 2020, Peer-reviewed

  
• 

  Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping.

  Peter Gee; Mandy S Y Lung; Yuya Okuzaki; Noriko Sasakawa; Takahiro Iguchi; Yukimasa Makita; Hiroyuki Hozumi; Yasutomo Miura; Lucy F Yang; Mio Iwasaki; Xiou H Wang; Matthew A Waller; Nanako Shirai; Yasuko O Abe; Yoko Fujita; Kei Watanabe; Akihiro Kagita; Kumiko A Iwabuchi; Masahiko Yasuda; Huaigeng Xu; Takeshi Noda; Jun Komano; Hidetoshi Sakurai; Naoto Inukai; Akitsu Hotta

  Nature communications, 13 Mar. 2020, Peer-reviewed

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• 事後ペプチドシーケンスタグの利用によるタンパク質同定の精度向上

  吉沢 明康; 田畑 剛; 岩崎 未央; 杉山 直幸; Kaell Lukas; 石濱 泰

  電気泳動, Jul. 2019, Peer-reviewed

  
• Removal of interference MS/MS spectra for accurate quantification in isobaric tag-based proteomics.

  Iwasaki M; Tabata T; Kawahara Y; Ishihama Y; Nakagawa M

  Journal of proteome research, Apr. 2019, Peer-reviewed, Lead author, Corresponding author

  
• The jPOST environment: an integrated proteomics data repository and database

  Yuki Moriya; Shin Kawano; Shujiro Okuda; Yu Watanabe; Masaki Matsumoto; Tomoyo Takami; Daiki Kobayashi; Yoshinori Yamanouchi; Norie Araki; Akiyasu C Yoshizawa; Tsuyoshi Tabata; Mio Iwasaki; Naoyuki Sugiyama; Satoshi Tanaka; Susumu Goto; Yasushi Ishihama

  Nucleic Acids Research, 08 Jan. 2019, Peer-reviewed

  
• Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.

  Yukitaka Ito; Sou Nakamura; Naoshi Sugimoto; Tomohiro Shigemori; Yoshikazu Kato; Mikiko Ohno; Shinya Sakuma; Keitaro Ito; Hiroki Kumon; Hidenori Hirose; Haruki Okamoto; Masayuki Nogawa; Mio Iwasaki; Shunsuke Kihara; Kosuke Fujio; Takuya Matsumoto; Natsumi Higashi; Kazuya Hashimoto; Akira Sawaguchi; Ken-Ichi Harimoto; Masato Nakagawa; Takuya Yamamoto; Makoto Handa; Naohide Watanabe; Eiichiro Nishi; Fumihito Arai; Satoshi Nishimura; Koji Eto

  Cell, 26 Jul. 2018, Peer-reviewed

  
• Artificial acceleration of mammalian cell reprogramming by bacterial proteins

  Takashi Ikeda; Ikuo Uchiyama; Mio Iwasaki; Tetsuhiko Sasaki; Masato Nakagawa; Keisuke Okita; Shinji Masui

  GENES TO CELLS, Oct. 2017, Peer-reviewed

  
• Efficient, Selective Removal of Human Pluripotent Stem Cells via Ecto-Alkaline Phosphatase-Mediated Aggregation of Synthetic Peptides

  Yi Kuang; Kenji Miki; Callum J.C. Parr; Karin Hayashi; Ikue Takei; Jie Li; Mio Iwasaki; Masato Nakagawa; Yoshinori Yoshida; Hirohide Saito

  Cell Chemical Biology, 22 Jun. 2017, Peer-reviewed

  
• 応用に向けたヒト多能性幹細胞の培養法の開発

  中川誠人; 小野美幸; 澤村由香; 川原優香; 岩崎未央; 秋藤千晶

  再生医療, 01 Feb. 2017

  
• Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells

  Hayami Sugiyama; Kazutoshi Takahashi; Takuya Yamamoto; Mio Iwasaki; Megumi Narita; Masahiro Nakamura; Tim A. Rand; Masato Nakagawa; Akira Watanabe; Shinya Yamanaka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2017, Peer-reviewed

  
• A multi-omic analysis of human naive CD4+T cells

  Christopher J. Mitchell; Derese Getnet; Min-Sik Kim; Srikanth S. Manda; Praveen Kumar; Tai-Chung Huang; Sneha M. Pinto; Raja Sekhar Nirujogi; Mio Iwasaki; Patrick G. Shaw; Xinyan Wu; Jun Zhong; Raghothama Chaerkady; Arivusudar Marimuthu; Babylakshmi Muthusamy; Nandini A. Sahasrabuddhe; Rajesh Raju; Caitlyn Bowman; Ludmila Danilova; Jevon Cutler; Dhanashree S. Kelkar; Charles G. Drake; T. S. Keshava Prasad; Luigi Marchionni; Peter N. Murakami; Alan F. Scott; Leming Shi; Jean Thierry-Mieg; Danielle Thierry-Mieg; Rafael Irizarry; Leslie Cope; Yasushi Ishihama; Charles Wang; Harsha Gowda; Akhilesh Pandey

  BMC SYSTEMS BIOLOGY, Nov. 2015, Peer-reviewed

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• 培養系がヒトES/iPS細胞に与える影響の解析

  中川誠人; 小野美幸; 澤村由香; 岩崎未央; 宮下一糸; 山中伸弥

  再生医療, 01 Feb. 2015

  
• Challenges Facing Complete Human Proteome Analysis

  IWASAKI MIO; ISHIHAMA YASUSHI

  Chromatography, 10 Aug. 2014, Lead author

  
• Rapid and Deep Profiling of Human Induced Pluripotent Stem Cell Proteome by One-shot NanoLC-MS/MS Analysis with Meter-scale Monolithic Silica Columns

  Ryota Yamana; Mio Iwasaki; Masaki Wakabayashi; Masato Nakagawa; Shinya Yamanaka; Yasushi Ishihama

  JOURNAL OF PROTEOME RESEARCH, Jan. 2013, Peer-reviewed, Lead author

  
• Human proteome analysis by using reversed phase monolithic silica capillary columns with enhanced sensitivity

  Mio Iwasaki; Naoyuki Sugiyama; Nobuo Tanaka; Yasushi Ishihama

  JOURNAL OF CHROMATOGRAPHY A, Mar. 2012, Peer-reviewed, Lead author

  
• One-Dimensional Capillary Liquid Chromatographic Separation Coupled with Tandem Mass Spectrometry Unveils the Escherichia coli Proteome on a Microarray Scale

  Mio Iwasaki; Shohei Miwa; Tohru Ikegami; Masaru Tomita; Nobuo Tanaka; Yasushi Ishihama

  ANALYTICAL CHEMISTRY, Apr. 2010, Peer-reviewed, Lead author

  
• Chemical Cleavage-Assisted Tryptic Digestion for Membrane Proteome Analysis

  Mio Iwasaki; Takeshi Masuda; Masaru Tomita; Yasushi Ishihama

  JOURNAL OF PROTEOME RESEARCH, Jun. 2009, Peer-reviewed, Lead author

  
• 

  Development of Basic Proteomics Technology Using Monolithic Silica Columns and Its Application to Analysis of Pluripotent Stem Cells

  Mio Iwasaki

  Proteome Letters, Jan. 2022, Peer-reviewed, Lead author, Corresponding author

  

Misc.

• jPOSTの10年間:プロテオーム統合データベースの未来に向けて

  吉沢明康; 高橋悠志; 小林大樹; 守屋勇樹; 幡野敦; 高見知代; 松本雅記; 荒木令江; 田畑剛; 田畑剛; 岩崎未央; 杉山直幸; 小寺義男; 福島敦史; 田中聡; 五斗進; 河野信; 河野信; 奥田修二郎; 石濱泰

  日本分子生物学会年会プログラム・要旨集(Web), 2024

  
• jPOST & JPDM: a database for proteomics and a journal for data articles

  吉沢明康; 小林大樹; 守屋勇樹; 幡野敦; 高見知代; 松本雅記; 荒木令江; 田畑剛; 田畑剛; 岩崎未央; 杉山直幸; 小寺義男; 田中聡; 五斗進; 河野信; 河野信; 奥田修二郎; 石濱泰

  日本分子生物学会年会プログラム・要旨集(Web), 2023

  

Presentations

• Elucidation of the new onset mechanism of Diamond-Blackfan anaemia through the control of proteostasis

  Mio Iwasaki

  2024年度分子生物学会[3PS-02] 多能性幹細胞を用いた研究の最新展開, 29 Nov. 2024, Invited

  
• Gene expression; do the differences in mRNA and protein abundance matter?

  Mio Iwasaki

  Kyushu University, Graduate School of Engineering, Department of Mechanical Engineering, Seminar, 26 Nov. 2024, Invited

  
• The protein levels of post-transcriptionally regulated genes determine stem cell fate into three germ layers

  Mio Iwasaki

  Japanese–German Research Symposium : Advancement and Application of Methods for Proteoform-Centric Proteomics, 16 Nov. 2024, Invited

  
• Exploring a Novel Pathogenic Mechanism of Diamond-Blackfan Anemia Through the Regulation of Proteostasis

  Mio Iwasaki

  CiRA-IREM Joint Symposium 2024: "Driving Next-generation Cell and Gene Therapy", 29 Oct. 2024, Invited

  
• Unraveling the differences in mRNA and protein abundance in pluripotent stem cells.

  Mio Iwasaki

  FY2024 Graduate School Seminar, Institute of Medical Science, The University of Tokyo, 28 Oct. 2024, Invited

  
• iPSC and gene expression focused on protein Level

  Mio Iwasaki

  Hokkaido University Graduate School Lectures, 17 Oct. 2024, Invited

  
• From being a young researcher to leading a laboratory

  Mio Iwasaki

  2024 Seminar on Cellular and Molecular Functional Science at Hokkaido University, 17 Oct. 2024, Invited

  
• Proteostasis research approaching from proteome analysis

  Mio Iwasaki

  2024 Seminar on Cellular and Molecular Functional Science, 17 Oct. 2024

  
• Multi-omics approach reveals post-transcriptionally regulated genes are essential for human pluripotent stem cells

  Mio Iwasaki

  4th Research Networking Salon, 27 Sep. 2024, Invited

  
• "Gene expression": does the difference between mRNA and protein abundance matter?

  Mio Iwasaki

  CIBoG/AI-MAILs Omics Analysis Program @Nagoya University, 24 Jul. 2024, Invited

  
• Novel Pathogenesis of Diamond-Blackfan Anemia Explored Through Regulation of Proteostasis

  Mio Iwasaki

  JPrOS2024@Aoyama, 27 Jun. 2024, Invited

  
• 未知なる細胞、その謎に迫る～細胞を知るためにタンパク質をはかる！～

  岩崎未央

  第36回CiRAカフェ, 23 Mar. 2024, Invited

  
• リボソームの細胞種類特異的なプロテオスタシスの理解と新規疾患発症機構の解明

  岩崎未央

  令和5年度プロテオスタシス領域会議, 07 Feb. 2024, Invited

  
• タンパク質の量制御による細胞運命解明を目指して

  岩崎未央

  第56回先端酵素学研究所・第7回リボソーム研究クラスターセミナー, 15 Jan. 2024, Invited

  
• "Gene expression": does the difference between mRNA and protein abundance matter?

  Mio Iwasaki

  First Contact Program@ASHBi, Kyoto University, 22 Dec. 2023, Invited

  
• Post-transcriptionally regulated genes are essential for human pluripotent stem cells

  Mio Iwasaki

  CiRA 2023 International Symposium, 29 Nov. 2023, Invited

  
• "Gene expression": does the difference between mRNA and protein abundance matter?

  Mio Iwasaki

  慶應義塾大学大学院講義「先端研究」, 14 Nov. 2023, Invited

  
• Post-transcriptionally regulated genes are essential for human pluripotent stem cells

  Mio Iwasaki

  Centre Seminar Series, The University of Edinburgh, 19 Oct. 2023, Invited

  
• プロテオーム解析による細胞機能の制御機構解明を目指して

  岩崎未央

  令和５年度プロテオスタシス領域PRIME会議, 13 Sep. 2023, Invited

  
• Post-transcriptionally regulated genes are essential for human pluripotent stem cells.

  Mio Iwasaki

  京都大学大学院教育コース「再生医療・臓器再建医学コース」, 08 Sep. 2023

  
• Post-transcriptional regulation and differentiation-specific gene clusters revealed by proteomics

  Mio Iwasaki

  JPrOS2023 (21st JHUPO), 26 Jul. 2023, Invited

  
• Proteomics reveals post-transcriptional regulatory genes and differentiation-specific secreted proteins

  Mio Iwasaki

  The 44th Annual Meeting of the Japanese Society of Inflammation and Regeneration, 12 Jul. 2023, Invited

  
• Understanding cell type-specific proteostasis of ribosomes and elucidating novel disease pathogenesis mechanisms

  Mio Iwasaki

  2022 Proteostasis Area Meeting, 09 Feb. 2023, Invited

  
• Elucidation of a novel mechanism for translation of incomplete-length proteins in human cells.

  Mio Iwasaki

  2022 iPS Academia Japan Presentation Ceremony, 02 Feb. 2023, Invited

  
• [1AW-14-7]Multi-omics reveals post-transcriptionally regulated gene clusters and their relationship to rare diseases

  Mio Iwasaki

  第45回分子生物学会年会「1AW-14: オミクスを重ねた解析から我々は何を知ることができるのか？」, 30 Nov. 2022

  
• Identification and quantitative comparative analysis of DDA and DIA at the 10,000 protein level (using timsTOFpro)

  Mio Iwasaki

  第10回 プロテオミクス トレーニングコース「伝授します！高深度プロテオーム解析技術」, 21 Oct. 2022, Invited

  
• Multi-omics analysis of RNA and proteins using healthy and patient-derived iPS cells

  Mio Iwasaki

  IIBMP2022, 14 Sep. 2022, Invited

  
• Discovery of genes required for the maintenance of human iPS and ES cells

  岩崎未央

  ProteinSimple, online seminor, 09 Sep. 2022, Invited

  
• 座長（スキルアップ、ジョブマッチングカフェ、オールジャンル）

  日本プロテオーム学会 2022 年大会, 08 Aug. 2022, Invited

  
• Multi-omics approach reveals post-transcriptionally regulated genes are essential for human pluripotent stem cells

  Mio Iwasaki

  Women and Future in Science@RIKEN BDR, 04 Jul. 2022, Invited

  
• iPS Cells and analysis of proteins

  Mio Iwasaki

  Online Media Study Group@CiRA, 13 Jun. 2022, Invited

  
• Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells

  Mio Iwasaki

  Kyoto University Graduate School of Education Course in Regenerative Medicine and Organ Reconstruction, 10 Jun. 2022, Invited

  
• Quantitative proteome analysis methods in 2022 -from single cell analysis to bulk analysis-.

  Mio Iwasaki

  Mass Spectrometry Informatics Research Group, 7th Open Workshop ONLINE (2022), 22 Apr. 2022, Invited

  
• Identification of a group of post-transcriptionally regulated genes required for maintenance of pluripotency

  Mio Iwasaki

  Mass Spectrometry Informatics Research Group, 7th Open Workshop ONLINE (2022), 22 Apr. 2022, Invited

  
• Elucidation of novel mechanism of incomplete length protein translation in human cells

  Mio Iwasaki

  iPS Academia Japan Research Grant 2021 Presentation Ceremony and Research Presentation, 02 Feb. 2022, Invited

  
• リボソームの細胞種類特異的なプロテオスタシスの理解と新規疾患発症機構の解明

  岩崎 未央

  令和3年度プロテオスタシス領域キックオフ・領域会議プログラム, 11 Jan. 2022, Invited

  
• Proteomics Reveals Post-transcriptional Regulatory Mechanisms（1PW-13-Introduction, 1PW-13-4）

  Mio Iwasaki

  MBSJ2021 1PW-13, 01 Dec. 2021, Invited

  
• Uncovering the functions of various proteins in iPS cells

  Mio Iwasaki

  Exploring Cutting-Edge Biotechnology Laboratories Series, 28 Nov. 2021, Invited

  
• Chair of Mentoring Session: Getting Started on Writing Manuscripts, Grants and Fellowships

  HUPO 2021 ReCONNECT, 19 Nov. 2021

  
• To identify post-transcriptionally regulated genes that are required for cell survival

  Mio Iwasaki

  14th K-CONNEX meeting, 22 Oct. 2021, Invited

  
• イオンモビリティー分離を利用した高深度プロテオーム解析

  岩崎 未央

  2021年度 BrukerバーチャルMSフォーラム, 03 Aug. 2021, Invited

  
• [3B17] モノリスシリカカラムを用いたプロテオミクス基盤技術の開発と多能性幹細胞解析への展開 (奨励賞受賞講演)

  岩崎 未央

  日本プロテオーム学会 2021年大会, 21 Jul. 2021, Invited

  
• [2C03] 多能性幹細胞に特異的な転写後制御機構の解明

  岩崎 未央

  日本プロテオーム学会 2021年大会, 20 Jul. 2021, Invited

  
• リボソームの細胞種類特異的なプロテオスタシスの理解と新規疾患発症機構の解明 (プロテオスタシス領域)

  岩崎 未央

  2021年度[CREST・さきがけ・ACT-X] [AMED-CREST・PRIME] 京都大学公募要領等説明会, 16 Apr. 2021, Invited

  
• Elucidation of cell type-specific post-transcriptional control mechanism

  Mio Iwasaki

  The 20th Congress of the Japanese Society for Regenerative Medicine., 11 Mar. 2021, Invited

  
• タンパク質の働きからiPS細胞の謎に迫る - 研究者への道 -

  岩崎未央

  早稲田塾 最先端科学プログラム, 07 Mar. 2021, Invited

  
• 細胞種類特異的な転写後制御機構の解明

  岩崎 未央

  第13回 K-CONNEX研究会, 12 Feb. 2021, Invited

  
• リボソームの細胞種類特異的なプロテオスタシスの理解と新規疾患発症機構の解明

  令和2年度プロテオスタシス研究開発領域キックオフミーティング, 13 Dec. 2020, Invited

  
• Global transcriptome and proteome profiling unveiled the unique post-transcriptional properties in PSCs.

  Mio Iwasaki

  The 43rd Annual Meeting of the Molecular Biology Society of Japan (online), 04 Dec. 2020, Invited

  
• Global transcriptome and proteome profiling unveiled the unique post-transcriptional properties in PSCs.

  Mio Iwasaki

  12th K-CONNEX MTG, 09 Oct. 2020, Invited

  
• Curiosity and Effort-The Road to Researchers-

  Mio Iwasaki

  Fukushima University Utsukushishima Fukushima Future Support Center / Kyoto University iPS Cell Research Institute Co-sponsored Symposium "Potential of Science Opening the Future-The Power of iPS Cell Researchers to Make Dreams Come True", 20 Aug. 2019, Invited

  
• Approaching the mystery of iPS cells from the function of proteins

  Mio Iwasaki

  9th High School Bio Summit Tsuruoka, 30 Jul. 2019, Invited

  
• Pros and cons of isobaric tag-based proteome quantification.

  M. Iwasaki; T. Tabata; Y. Kawahara; Y. Ishihama; M. Nakagawa

  JPrOS2019, 24 Jul. 2019, Invited

  
• プロテオーム解析手法の進歩と課題-iPS細胞への応用に向けて-

  岩崎未央

  理化学研究所 バイオリソース研究センターiPS創薬基盤開発チーム, 07 Sep. 2018, Invited

  
• Development of interference spectra removal method to increase quantification accuracy for isobaric tag-based quantification

  Mio Iwasaki

  NHK文化センター梅田, 22 Aug. 2018, Invited

  
• Development of interference spectra removal method to increase quantification accuracy for isobaric tag-based quantification

  Mio Iwasaki

  第7回K-CONNEX研究会, 27 Jul. 2018, Invited

  
• Development of interference spectra removal method to increase quantification accuracy

  Mio Iwasaki

  Japanese Proteomics Society 2018 Conference (JPrOS 2018), 9th Asia-Oceania Human Proteome Organization (AOHUPO), and 66th Annual Conference on Mass Spectrometry, Japan, 17 May 2018

  
• タンパク質の量制御機構と細胞運命

  岩崎未央

  ファーストコンタクトプログラム（京都リサーチパーク）, 15 Mar. 2018, Invited

  
• 遺伝子発現量の制御機構を明らかにするためのオミクスデータ解析

  岩崎未央; 田畑剛; 川原優香; 小野美幸; 成田恵; 山中伸弥; 中川誠人

  2017年度生命科学系学会合同年次大会（ConBio2017）, 07 Dec. 2017

  
• タンパク質の量の直接的制御につながる遺伝子転写後制御機構の解明

  岩崎未央

  ファーストコンタクトプログラム（化学メーカー）, 24 Aug. 2017, Invited

  
• 遺伝子発現の量的・質的制御を明らかにするためのタンパク質定量解析手法の開発

  岩崎未央

  第4回K-CONNEX研究会, 28 Jul. 2017, Invited

  
• The mechanism of post-transcriptional control in human induced pluripotent stem cells by analyses of global transcriptome and proteome data.

  Mio Iwasaki

  1st symposium of Kyoto Biomolecular Mass Spectrometry Society, 07 Feb. 2017

  
• The mechanism of post-transcriptional control in human induced pluripotent stem cells by analyses of global transcriptome and proteome data.

  岩崎未央; 川原優香; 小野美幸; 澤村由香; 山中伸弥; 中川誠人

  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会, 04 Dec. 2015

  
• Mechanism of post-transcriptional regulation in human induced pluripotent stem cells by analyses of global transcriptome and proteome data

  ○Mio Iwasaki; Yuka Kawahara; Miyuki Ono; Yuka Sawamura; Shinya Yamanaka; Masato Nakagawa

  日本プロテオーム学会2015年会（JHUPO第13回大会）, 23 Jul. 2015

  
• 転写産物および蛋白質の大規模発現量データを用いたヒト人工多能性幹細胞における転写後制御機能解析（2W7-8）

  岩崎未央; 川原優香; 小野美幸; 石濱泰; 山中伸弥; 中川誠人

  第37回日本分子生物学会年会, 26 Nov. 2014

  
• 転写産物および蛋白質の大規模発現量データを用いたヒト人工多能性幹細胞における転写後制御機能解析（2P-0596）

  岩崎未央; 川原優香; 小野美幸; 石濱泰; 山中伸弥; 中川誠人

  第37回日本分子生物学会年会, 26 Nov. 2014

  
• Deep Subcellular Proteome Profiling of Human Induced Pluripotent Stem Cell by One-shot nanoLC-MS/MS Analyses with Meter-scale Monolithic Silica Columns（POS-03-LB-060）

  ○Mio Iwasaki; Masato Nakagawa; Yasushi Ishihama; Shinya Yamanaka

  HUPO 12th annual world congress, 16 Sep. 2013

  
• Deep Subcellular Proteome Profiling of Human Induced Pluripotent Stem Cell by One-Shot NanoLC-MS/MS Analyses with Meter-Scale Monolithic Silica Columns

  ○Mio Iwasaki; Masato Nakagawa; Yasushi Ishihama; Shinya Yamanaka

  HUPO 12th annual world congress, HPP Initiative Session 3: Proteome Biology of Stem Cells, 14 Sep. 2013

  
• メートル長キャピラリーカラムを用いる高深度プロテオーム解析システムに関する研究

  岩崎未央

  第3回日本質量分析学会 春季シンポジウム (第141回 日本質量分析学会関西談話会), 20 Jun. 2013

  
• In-depth human proteome analysis by one-shot LC-MS/MS with meter-scale monolithic silica capillary columns

  ○Mio Iwasaki; Masaki Wakabayashi; Naoyuki Sugiyama; Nobuo Tanaka; Yasushi Ishihama

  19th International Mass Spectrometry Conference, 15 Sep. 2012

  
• Toward Complete Coverage of Human Proteome by One-Shot LC-MS/MS with Meter-Scale Monolithic Silica Capillary Columns

  ○Mio Iwasaki; Masaki Wakabayashi; Naoyuki Sugiyama; Nobuo Tanaka; Yasushi Ishihama

  HUPO 11th annual world congress, 09 Sep. 2012

  
• Toward Complete Coverage of Human Proteome by One-Shot LC-MS/MS with Meter-Scale Monolithic Silica Capillary Columns（Poster 428）

  ○Mio Iwasaki; Masaki Wakabayashi; Naoyuki Sugiyama; Nobuo Tanaka; Yasushi Ishihama

  HUPO 11th annual world congress, 09 Sep. 2012

  
• One-shot nanoLC-MS/MSシステムによる10,000ヒトリン酸化ペプチドの一斉解析

  岩崎未央; 若林真樹; 杉山直幸; 田中信男; 石濱泰

  日本プロテオーム学会 2012年大会, 26 Jul. 2012

  
• Toward 10,000 phosphopeptide identification by one-shot LC-MS/MS analysis with meter-scale monolithic silica capillary columns

  ○Mio Iwasaki

  7th SKO Joint Symposium on Pharmaceutical Sciences for Young Scientists, 23 May 2012

  
• Toward 10,000 phosphopeptide identification by one-shot LC-MS/MS analysis with meter-scale monolithic silica capillary columns

  ○Mio Iwasaki; Masaki Wakabayashi; Naoyuki Sugiyama; Nobuo Tanaka; Yasushi Ishihama

  6th Congress of Asia Oceania Human Proteome Organization, 05 May 2012

  
• メートル長モノリス型シリカカラムを用いたヒト培養細胞のショットガンプロテオーム解析

  岩崎未央; 若林真樹; 中野実; 田中信男; 石濱泰

  日本プロテオーム学会2011年大会, 28 Jul. 2011

  
• 複雑な試料成分の分析における高分離能の必要性について

  岩崎未央; 石濱泰

  The 38th Biological Mass Spectrometry Conference, 10 Jul. 2011

  
• 大腸菌プロテオーム一斉解析システムの開発

  岩崎未央; 石濱泰

  微生物化学寄附研究部門主催シンポジウム, 23 Jun. 2011

  
• リン酸化プロテオーム解析のためのnanoLC-MS/MSシステムの開発（O-08）

  岩崎未央; 三輪昌平; 池上亨; 冨田勝; 田中信男; 石濱泰

  第21回クロマトグラフィー科学会議, 21 Oct. 2010

  
• プロテオミクスLC-MSにおける挑戦（E-5）

  岩崎未央; 冨田勝; 石濱泰

  第23回バイオメディカル分析科学シンポジウム, 21 Jul. 2010

  
• 発現プロテオーム一斉分析へ向けたnanoLC-MS/MSシステムの開発（16P-065）

  岩崎未央; 三輪昌平; 池上亨; 冨田勝; 田中信男; 石濱泰

  第58回質量分析総合討論会, 16 Jun. 2010

  
• One‐Dimensional Capillary Liquid Chromatographic Separation Coupled with Tandem Mass Spectrometry Unveils Entire Proteome Expressed in Escherichia coli cells（ThP 125）

  ○Mio Iwasaki; Shohei Miwa; Oleg V. Krokhin; Masaru Tomita; Nobuo Tanaka; Yasushi Ishihama

  58th ASMS Conference on Mass Spectrometry, 27 May 2010

  
• Development of nanoLC-MS systems for membrane proteome analysis (1P-0085)

  Mio Iwasaki; Shohei Miwa; Masaru Tomita; Nobuo Tanaka; Yasushi Ishihama

  第32回日本分子生物学会年会, 09 Dec. 2009

  
• 大腸菌全プロテオーム解析へ向けたnanoLC-MS/MSシステムの開発（O-06）

  岩崎未央; 三輪昌平; 冨田勝; 田中信男; 石濱泰

  第20回クロマトグラフィー科学会議, 11 Nov. 2009

  
• Cysteine chemical cleavage-assisted tryptic digestion for membrane proteomics（ThP 511）

  ○Mio Iwasaki; Takeshi Masuda; Masaru Tomita; Yasushi Ishihama

  57th ASMS Conference on Mass Spectrometry, 04 Jun. 2009

  
• シアノシステインによる化学的消化法の開発と膜プロテオミクスへの応用（4P-1283）

  岩崎未央; 増田豪; 冨田勝; 石濱泰

  第31回日本分子生物学会年会・第81回日本生化学会大会 合同大会, 12 Dec. 2008

  
• Membrane proteome profiling of Escherichia coli using chemical digestion-based shotgun proteomics（Wed 7-2 (E-4)）

  ○Mio Iwasaki; Takeshi Masuda; Masaru Tomita; Yasushi Ishihama

  2nd Taiwan-Japan Young Researchers Conference on Computational and Systems Biology, 05 Nov. 2008

  
• Membrane proteome profiling of Escherichia coli using chemical digestion-based shotgun proteomics（E-4）

  ○Mio Iwasaki; Takeshi Masuda; Masaru Tomita; Yasushi Ishihama

  2nd Taiwan-Japan Young Researchers Conference on Computational and Systems Biology, 05 Nov. 2008

  
• メンブレンプロテオミクスの為の化学的消化法の開発（2P-1467）

  岩崎未央; 増田豪; 冨田勝; 石濱泰

  第30回日本分子生物学会年会・第80回日本生化学会大会 合同大会, 12 Dec. 2007

  
• Functional analysis of alternative splicing isoforms in human induced pluripotent stem cells.

  岩崎未央; 川原優香; 澤村由香; 小野美幸; 中川誠人

  第39回日本分子生物学会年会

  

Books and Other Publications

• Multiomics

  Risa K. Kawaguchi; Mio Iwasaki, Joint work, 第2章3.1細胞レベルのマルチオミクス解析のための基盤技術

  羊土社, Sep. 2023

  Find Kyoto University's collection of books :

  
• Generation of human iPS cells using chemical compounds

  Tatsuya Yamakawa; Mio Iwasaki, Joint work

  Chemistry Today, Sep. 2022

  
• The whole picture of phase separation biology

  Edited by Kentaro Shiraki; Mio Iwasaki, Contributor, Chapter 77: Current Status and Prospects of Comprehensive Protein Analysis Technology

  Tokyo Kagaku Dojin, Nov. 2020

  Find Kyoto University's collection of books :

  
• Making iPS cells with chemical compounds

  Mio Iwasaki, Single work, Chemistry today (593), 22-28, 2020-08

  Tokyo Kagaku Dojin, Aug. 2020

  

External funds: Kakenhi

• Understanding the biological roles of circular RNAs through the analysis of their translation mechanisms

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38060:Applied molecular and cellular biology-related

  Kyoto University

  Kazutoshi Takahashi

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  環状RNA;非標準的翻訳;多能性幹細胞;翻訳;リボソームプロファイリング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02155/
• Expanded understanding of molecular mechanisms governing pluripotency by focusing on non-canonical translation.

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  Kyoto University

  高橋 和利

  From 30 Jul. 2020, To 31 Mar. 2026, Granted

  翻訳;多能性幹細胞;非標準的翻訳;分化多能性;リボソーム;プロテオミクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K20585/
• Development of a novel method for de novo sequencing of amino acid sequences by mass spectrometry

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43060:System genome science-related

  Toyama University of International Studies

  Shin Kawano

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  タンパク質;質量分析;アミノ酸配列決定;アミノ酸組成分析;de novo sequencing;プロテオーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03245/
• Analysis of protein quantity control mechanism and differentiation specificity

  Grant-in-Aid for Early-Career Scientists

  Basic Section 43050:Genome biology-related

  Kyoto University

  Mio Iwasaki

  From 01 Apr. 2019, To 31 Mar. 2021, Project Closed

  転写後制御機構;神経前駆細胞;プロテオミクス;転写後制御;神経系細胞;タンパク質;分化特異性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16104/
• 近傍集積因子解析よるCRISPR-Cas3ゲノム欠失誘導機構の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43050:Genome biology-related

  Kyoto University

  堀田 秋津

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  CRISPR-Cas3;ゲノム編集;DNA損傷修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02601/
• 核膜複合体によるmRNA局在制御機構の解明

  Grant-in-Aid for Scientific Research (C)

  Basic Section 43030:Functional biochemistry-related

  Kyoto University

  岩崎 未央

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  核膜複合体;リン酸化;mRNA輸送;核膜孔複合体;mRNA;局在

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K05680/
• 近傍集積因子解析よるCRISPR-Cas3ゲノム欠失誘導機構の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43050:Genome biology-related

  Kyoto University

  堀田 秋津

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  ゲノム編集;CRISPR-Cas3;DNA損傷修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K23864/

Education

Teaching subject(s)

• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From Apr. 2020, To Mar. 2021

  ILAS Seminar :Introduction to iPS cells

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  ILAS Seminar :Introduction to iPS cell research

  Spring, 全学共通科目

Administration

Faculty management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2026

  共通機器管理運営委員会
• From 01 Apr. 2021, To 31 Mar. 2022

  化学物質管理委員会
• From 01 Apr. 2020, To 31 Mar. 2025

  倫理審査委員会1号委員

Academic, Social Contribution

Committee Memberships

• From May 2021, To Present

  Member of Early Career Researcher (ECR) initiative, Human Proteome Organization (HUPO)
• From Jan. 2021, To Dec. 2023

  Director, Japanese Proteomics Society