Basic Information

Academic Degree

• 24 Sep. 2012

  京都大学博士（医学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程医学専攻, 修了
• 京都大学, 大学院医学研究科博士課程医学専攻, 研究指導認定退学

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

Research History

• From Apr. 2025, To Present

  Kyoto University Hospital, Department of Cardiovascular Surgery, Project-Specific Professor
• From Jul. 2023, To Mar. 2025

  京都大学医学部附属病院, 心臓血管外科, 特定准教授
• From Apr. 2018, To Mar. 2025

  理化学研究所生命機能科学研究センター（組織改組に伴う名称変更）, 臨床橋渡しプログラム・升本研究室, 研究リーダー
• From Oct. 2017, To Mar. 2023

  京都大学医学部附属病院, 心臓血管外科, 特定助教
• From Oct. 2017, To Mar. 2018

  理化学研究所多細胞システム形成研究センター, 臨床橋渡しプログラム・升本研究室, 研究リーダー
• From Oct. 2016, To Sep. 2017

  京都大学医学部附属病院, 心臓血管外科, 助教
• From Sep. 2015, To Sep. 2016

  Kyoto University, iPS細胞研究所（CiRA）, 特定研究員（特命助教）
• From Sep. 2013, To Aug. 2015

  米国Louisville大学, Cardiovascular Innovation Institute, 博士研究員
• From May 2012, To Aug. 2013

  京都大学医学部附属病院, 心臓血管外科, 特定病院助教
• From Nov. 2002, To Apr. 2008

  静岡市立静岡病院, 心臓血管外科, 医員
• From Mar. 2000, To Oct. 2002

  国家公務員共済組合連合会 熊本中央病院, 心臓血管外科, 医員
• From May 1999, To Feb. 2000

  Kyoto University Hospital, Department of Cardiovascular Surgery, 研修医

Profile

• Profile

  医学博士。再生医療認定医・循環器専門医。1999年京都大学医学部卒。熊本中央病院および静岡市立静岡病院心臓血管外科 医員、米国Louisville大学博士研究員、京都大学iPS細胞研究所特命助教などを経て、2023年より京都大学医学部付属病院心臓血管外科特定准教授、2025年4月より現職。また2017年10月から2025年3月まで理化学研究所生命機能科学研究センター臨床橋渡しプログラム研究リーダーとして研究室を主宰（2025年4月～理研客員主管研究員）。2023年よりNovartis Institute for BioMedical Researchからの国際大型グラント NIBR Global Scholars Programを研究代表者として受領（日本初）。iPS細胞から作製した心臓オルガノイドの構造および機能的成熟化に関する研究を軸に、重症心臓病に対する新たな再生医療の開発、あるいは心臓病の再現による創薬研究に取り組んでいる。

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201601017763898648

• External link

  https://ngcmdp.kuhp.kyoto-u.ac.jp/en.html

Website(s) (URL(s))

• https://www.bdr.riken.jp/ja/research/labs/masumoto-h/index.html

researchmap URL

• https://researchmap.jp/7000018347

Research

Research Topics, Overview of the research

• Research Topics

  Regenerative medicine in cardiovascular surgery

• Overview of the research

  Generation of human iPS cell-derived 3-dimensional cardiac tissue and the clinical application

Research Interests

• Tissue engineering
• Stem cell biology
• Clinical translational research
• Cardiology
• Cardiovascular surgery
• Regenerative medicine

Research Areas

• Life sciences, Cardiovascular surgery

Papers

• Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin.

  Jun Iida; Kazuki Kotani; Kozue Murata; Keisuke Hakamada; Wusiman Maihemuti; Yoshinobu Mandai; Yosuke Hiraoka; Kenji Minatoya; Hidetoshi Masumoto

  Scientific reports, 07 Feb. 2025, Peer-reviewed, Last author, Corresponding author

  
• Surgical repair of coronary arteriovenous fistula: A simple and useful approach to identify the fistulous communication

  Kim Hyun Il; Takaaki Koshiji; Minoru Okamoto; Yoshio Arai; Hidetoshi Masumoto

  European Journal of Cardio-thoracic Surgery, 2001

  
• Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells

  Wusiman Maihemuti; Kozue Murata; Mosha Abulaiti; Kenji Minatoya; Hidetoshi Masumoto

  Biochemical and Biophysical Research Communications, Nov. 2024, Peer-reviewed, Last author, Corresponding author

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• Progress in the generation of multiple lineage human-iPSC-derived 3D-engineered cardiac tissues for cardiac repair

  Fei Ye; Shuji Setozaki; William J. Kowalski; Marc Dwenger; Fangping Yuan; Joseph P. Tinney; Takeichiro Nakane; Hidetoshi Masumoto; Bradley B. Keller

  Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension, 01 Jan. 2020

  
• miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes.

  Qiaoke Yang; Kozue Murata; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto

  Scientific reports, 27 Jun. 2024, Peer-reviewed, Last author, Corresponding author

  
• ヒトiPS細胞由来の薬剤誘発性Torsade de Pointes再現心臓組織モデル

  川東 正英; 升本 英利; 森永 学; 芦原 貴司; 山下 潤

  日本内分泌学会雑誌, Dec. 2018

  
• Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model.

  Kozue Murata; Akiko Makino; Keizo Tomonaga; Hidetoshi Masumoto

  iScience, 19 Jan. 2024, Peer-reviewed, Last author, Corresponding author

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• Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device.

  Daisuke Heima; Masafumi Takeda; Yasuhiko Tabata; Kenji Minatoya; Jun K Yamashita; Hidetoshi Masumoto

  The Journal of thoracic and cardiovascular surgery, 21 Nov. 2023, Peer-reviewed, Last author, Corresponding author

  
• 拡張型心筋症モデルハムスターの網羅的代謝イメージング解析

  岡邑 舞子; 山口 真一; 山本 卓志; 袴田 圭祐; 新谷 祈; 辻 崇; 植田 初江; 雨宮 妃; 湊谷 謙司; 升本 英利; 池川 雅哉

  JSBMS Letters, Aug. 2022

  
• Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.

  Shoichi Kyo; Kozue Murata; Masahide Kawatou; Kenji Minatoya; Genshiro A Sunagawa; Hidetoshi Masumoto

  JTCVS open, Dec. 2022, Peer-reviewed, Last author, Corresponding author

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• A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture

  Wen-Jin Ho; Mako Kobayashi; Kozue Murata; Yoshihide Hashimoto; Kenji Izumi; Tsuyoshi Kimura; Hideo Kanemitsu; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto

  Scientific Reports, 24 Dec. 2022, Peer-reviewed, Last author, Corresponding author

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• 拡張型心筋症モデルハムスターの網羅的代謝イメージング解析

  岡邑 舞子; 山口 真一; 山本 卓志; 袴田 圭祐; 新谷 祈; 辻 崇; 植田 初江; 雨宮 妃; 湊谷 謙司; 升本 英利; 池川 雅哉

  JSBMS Letters, Aug. 2022

  
• Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction.

  Yasushi Konegawa; Toshie Kuwahara; Jun-Ichiro Jo; Kozue Murata; Takahide Takeda; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto; Yasuhiko Tabata

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 10 Aug. 2022, Peer-reviewed, Corresponding author

  
• Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells.

  Kozue Murata; Hidetoshi Masumoto

  Stem cells (Dayton, Ohio), 22 Jun. 2022, Peer-reviewed, Last author, Corresponding author

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• Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models.

  Yasue Fujiwara; Shingo Hirao; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto

  Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, Mar. 2022, Peer-reviewed, Last author, Corresponding author

  
• Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues

  Hiroaki Osada; Masahide Kawatou; Daiki Fujita; Yasuhiko Tabata; Kenji Minatoya; Jun K. Yamashita; Hidetoshi Masumoto

  JTCVS Open, Dec. 2021, Peer-reviewed, Last author, Corresponding author

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• In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model

  Shunji Kurokawa; Yoshihide Hashimoto; Seiichi Funamoto; Kozue Murata; Akitatsu Yamashita; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto

  PLOS ONE, 22 Jul. 2021, Peer-reviewed, Last author, Corresponding author

  
• Generation of Cylindrical Engineered Cardiac Tissues from Human iPS Cell-Derived Cardiovascular Cell Lineages.

  Hidetoshi Masumoto

  Methods in molecular biology (Clifton, N.J.), 2021, Peer-reviewed, Lead author, Corresponding author

  
• Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues

  Marc Dwenger; William J. Kowalski; Hidetoshi Masumoto; Takeichiro Nakane; Bradley B. Keller

  Methods in Molecular Biology, 2021, Peer-reviewed

  
• Strategies for immune regulation in iPS cell-based cardiac regenerative medicine

  Kozue Murata; Masaya Ikegawa; Kenji Minatoya; Hidetoshi Masumoto

  Inflammation and Regeneration, Dec. 2020, Peer-reviewed, Last author, Corresponding author

  
• Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function

  Mosha Abulaiti; Yaxiaer Yalikun; Kozue Murata; Asako Sato; Mustafa M. Sami; Yuko Sasaki; Yasue Fujiwara; Kenji Minatoya; Yuji Shiba; Yo Tanaka; Hidetoshi Masumoto

  Scientific Reports, Dec. 2020, Peer-reviewed, Last author, Corresponding author

  
• Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator

  Hiroaki Osada; Wen-Jin Ho; Hideki Yamashita; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto

  Regenerative Therapy, Dec. 2020, Peer-reviewed, Last author, Corresponding author

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• The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model

  Tatsuya Itonaga; Shingo Hirao; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto

  General Thoracic and Cardiovascular Surgery, Aug. 2020, Peer-reviewed, Last author, Corresponding author

  
• Management of retrosternal adhesion after median sternotomy by controlling degradation speed of a dextran and ε-poly (l-lysine)-based biocompatible glue

  Fumie Takai; Takahide Takeda; Kazuhiro Yamazaki; Tadashi Ikeda; Suong-Hyu Hyon; Kenji Minatoya; Hidetoshi Masumoto

  General Thoracic and Cardiovascular Surgery, Aug. 2020, Peer-reviewed, Last author, Corresponding author

  
• Accuracy of spiked cell counting methods for designing a pre-clinical tumorigenicity study model.

  Hiroaki Osada; Masahide Kawatou; Masafumi Takeda; Jun-Ichiro Jo; Takashi Murakami; Yasuhiko Tabata; Kenji Minatoya; Jun K Yamashita; Hidetoshi Masumoto

  Heliyon, Jul. 2020, Peer-reviewed, Last author, Corresponding author

  
• Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair

  Takeichiro Nakane; Mosha Abulaiti; Yuko Sasaki; William J. Kowalski; Bradley B. Keller; Hidetoshi Masumoto

  Journal of Visualized Experiments, 09 Jun. 2020, Peer-reviewed, Last author, Corresponding author

  
• A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure

  Hiroomi Nishio; Kenji Minatoya; Hidetoshi Masumoto

  Journal of Visualized Experiments, 15 May 2020, Peer-reviewed, Last author, Corresponding author

  
• Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model.

  Atsushi Nagasawa; Hidetoshi Masumoto; Shigeki Yanagi; Naoki Kanemitsu; Tadashi Ikeda; Yasuhiko Tabata; Kenji Minatoya

  General thoracic and cardiovascular surgery, Apr. 2020, Peer-reviewed

  
• Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues

  Marc Dwenger; William J Kowalski; Fei Ye; Fangping Yuan; Joseph P Tinney; Shuji Setozaki; Takeichiro Nakane; Hidetoshi Masumoto; Peter Campbell; William Guido; Bradley B Keller

  Journal of Tissue Engineering, Jan. 2019, Peer-reviewed

  
• Development of a bioassay system to evaluate the pulsatile function of human heart tissue using a cellular micropump on-chip and a biomimetic human iPS cell-derived heart tissue sheet technology

  Abulaiti Mosha; Kozue Murata; Yalikun Yaxiaer; Yo Tanaka; Hidetoshi Masumoto

  Proceeding of Micro Total Analysis Systems 2018, Nov. 2018, Peer-reviewed, Last author, Corresponding author

  
• Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model.

  Li Z; Masumoto H; Jo JI; Yamazaki K; Ikeda T; Tabata Y; Minatoya K

  General thoracic and cardiovascular surgery, Nov. 2018, Peer-reviewed, Corresponding author

  
• MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model.

  Nishio H; Masumoto H; Sakamoto K; Yamazaki K; Ikeda T; Minatoya K

  The Journal of thoracic and cardiovascular surgery, Oct. 2018, Peer-reviewed, Corresponding author

  
• Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia.

  Tsumaru S; Masumoto H; Minakata K; Izuhara M; Yamazaki K; Ikeda T; Ono K; Sakata R; Minatoya K

  Journal of vascular surgery, Oct. 2018, Peer-reviewed, Corresponding author

  
• 拡張型心筋症ハムスターモデルの病態解析と超高速イメージング質量分析法を用いたプロテオミック・バイオマーカー探索

  新谷 祈; 辻 崇; 石田 瑞希; 韮澤 崇; 植田 初江; 升本 英利; 湊谷 謙司; 池川 雅哉

  JSBMS Letters, Aug. 2018

  
• A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model

  Motoyuki Kumagai; Kenji Minakata; Hidetoshi Masumoto; Masaya Yamamoto; Atsushi Yonezawa; Takafumi Ikeda; Kyokun Uehara; Kazuhiro Yamazaki; Tadashi Ikeda; Kazuo Matsubara; Masayuki Yokode; Akira Shimizu; Yasuhiko Tabata; Ryuzo Sakata; Kenji Minatoya

  Heart and Vessels, 14 May 2018, Peer-reviewed, Corresponding author

  
• A recovery cardiopulmonary bypass model without transfusion or inotropic agents in rats

  Shingo Hirao; Hidetoshi Masumoto; Tatsuya Itonaga; Kenji Minatoya

  Journal of Visualized Experiments, 20 Mar. 2018, Peer-reviewed, Corresponding author

  
• Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82

  Masafumi Takeda; Yasuharu Kanki; Hidetoshi Masumoto; Shunsuke Funakoshi; Takeshi Hatani; Hiroyuki Fukushima; Akashi Izumi-Taguchi; Yusuke Matsui; Teppei Shimamura; Yoshinori Yoshida; Jun K. Yamashita

  Cell Reports, 2018, Peer-reviewed

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• Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts.

  Ishigami M; Masumoto H; Ikuno T; Aoki T; Kawatou M; Minakata K; Ikeda T; Sakata R; Yamashita JK; Minatoya K

  PloS one, 2018, Peer-reviewed, Corresponding author

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• Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft.

  Masumoto H; Yamashita JK

  Inflammation and regeneration, 2018, Peer-reviewed, Lead author, Corresponding author

  
• Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model

  Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Ryuzo Sakata

  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Dec. 2017, Peer-reviewed, Corresponding author

  
• Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

  Masahide Kawatou; Hidetoshi Masumoto; Hiroyuki Fukushima; Gaku Morinaga; Ryuzo Sakata; Takashi Ashihara; Jun K. Yamashita

  NATURE COMMUNICATIONS, Oct. 2017, Peer-reviewed

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• Quantification of Cardiomyocyte Alignment from Three-Dimensional (3D) Confocal Microscopy of Engineered Tissue

  William J. Kowalski; Fangping Yuan; Takeichiro Nakane; Hidetoshi Masumoto; Marc Dwenger; Fei Ye; Joseph P. Tinney; Bradley B. Keller

  MICROSCOPY AND MICROANALYSIS, Aug. 2017, Peer-reviewed

  
• Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model

  Shuji Setozaki; Kenji Minakata; Hidetoshi Masumoto; Shingo Hirao; Kazuhiro Yamazaki; Koichiro Kuwahara; Tadashi Ikeda; Ryuzo Sakata

  JOURNAL OF VASCULAR SURGERY, Jun. 2017, Peer-reviewed

  
• Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017)

  Takeshi Ikuno; Hidetoshi Masumoto; Kohei Yamamizu; Miki Yoshioka; Kenji Minakata; Tadashi Ikeda; Ryuzo Sakata; Jun K. Yamashita

  PLOS ONE, Apr. 2017, Peer-reviewed

  
• Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue

  Takeichiro Nakane; Hidetoshi Masumoto; Joseph P. Tinney; Fangping Yuan; William J. Kowalski; Fei Ye; Amanda J. LeBlanc; Ryuzo Sakata; Jun K. Yamashita; Bradley B. Keller

  SCIENTIFIC REPORTS, Apr. 2017, Peer-reviewed

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• Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017)

  Takeshi Ikuno; Hidetoshi Masumoto; Kohei Yamamizu; Miki Yoshioka; Kenji Minakata; Tadashi Ikeda; Ryuzo Sakata; Jun K. Yamashita

  PLOS ONE, Apr. 2017, Peer-reviewed

  
• Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model

  Tomofumi Taki; Hidetoshi Masumoto; Masaki Funamoto; Kenji Minakata; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata

  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2017, Peer-reviewed, Corresponding author

  
• Untiring steps toward the maturation of human stem cell-engineered heart tissue

  Hidetoshi Masumoto; Jun K. Yamashita

  Annals of Translational Medicine, 01 Feb. 2017, Peer-reviewed, Lead author, Corresponding author

  
• Therapeutic angiogenesis with growth factor using drug delivery system in cardiovascular medicine

  Kenji Minakata; Hiroomi Nishio; Hidetoshi Masumoto; Ryuzo Sakata

  Drug Delivery System, 2017, Peer-reviewed

  
• Human iPS Cell-Derived Cardiac Tissue Sheets: a Platform for Cardiac Regeneration

  Hidetoshi Masumoto; Jun K. Yamashita

  Current Treatment Options in Cardiovascular Medicine, 01 Nov. 2016, Peer-reviewed, Lead author, Corresponding author

  
• The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages

  Hidetoshi Masumoto; Takeichiro Nakane; Joseph P. Tinney; Fangping Yuan; Fei Ye; William J. Kowalski; Kenji Minakata; Ryuzo Sakata; Jun K. Yamashita; Bradley B. Keller

  SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed, Lead author

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• Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass

  Masaki Funamoto; Hidetoshi Masumoto; Koji Takaori; Tomofumi Taki; Shuji Setozaki; Kazuhiro Yamazaki; Kenji Minakata; Tadashi Ikeda; Suong-Hyu Hyon; Ryuzo Sakata

  ANNALS OF THORACIC SURGERY, Apr. 2016, Peer-reviewed

  
• Exploiting human iPS cell-derived cardiovascular cell populations toward cardiac regenerative therapy.

  Masumoto H; Yamashita JK

  Stem Cell Transl Investig, 2016, Peer-reviewed, Lead author, Corresponding author

  
• Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes

  Keller BB; Ye F; Yuan F; Trada H; Tinney JP; Walsh KM; Masumoto H; Nakanishi T; Markwald RR; Baldwin HS; Keller BB; Srivastava D; Yamagishi H

  2016, Peer-reviewed

  
• ブタ心筋梗塞モデルを用いたiPS細胞由来心臓組織シート移植による不整脈評価実験

  幾野 毅; 青木 隆之; 升本 英利; 小原 浩; 中村 裕二; 中瀬古 寛子; 安東 賢太郎; 川東 正英; 石上 雅之助; 南方 謙二; 池田 義; 杉山 篤; 山下 潤; 坂田 隆造

  日本バイオマテリアル学会大会予稿集, Nov. 2015

  
• Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells

  Takehiko Matsuo; Hidetoshi Masumoto; Shuhei Tajima; Takeshi Ikuno; Shiori Katayama; Kenji Minakata; Tadashi Ikeda; Kohei Yamamizu; Yasuhiko Tabata; Ryuzo Sakata; Jun K. Yamashita

  SCIENTIFIC REPORTS, Nov. 2015, Peer-reviewed

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• Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration

  Hidetoshi Masumoto; Takeshi Ikuno; Masafumi Takeda; Hiroyuki Fukushima; Akira Marui; Shiori Katayama; Tatsuya Shimizu; Tadashi Ikeda; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita

  SCIENTIFIC REPORTS, Oct. 2014, Peer-reviewed, Lead author

  
• Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype

  Motoaki Ohnaka; Akira Marui; Kenichi Yamahara; Kenji Minakata; Kazuhiro Yamazaki; Motoyuki Kumagai; Hidetoshi Masumoto; Shiro Tanaka; Tadashi Ikeda; Ryuzo Sakata

  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Aug. 2014, Peer-reviewed

  
• Effects of hepatocyte growth factor in myocarditis rats induced by immunization with porcine cardiac myosin

  Jota Nakano; Akira Marui; Hiroyuki Muranaka; Hidetoshi Masumoto; Hisashi Noma; Yasuhiko Tabata; Akio Ido; Hirohito Tsubouchi; Tadashi Ikeda; Ryuzo Sakata

  INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Mar. 2014, Peer-reviewed

  
• Efficiently Piled-Up Cardiac Tissue-Like Sheets With Pluripotent Stem Cell-Derived Cells Robustly Promotes Cell Engraftment and Ameliorates Cardiac Dysfunction After Myocardial Infarction

  Takehiko Matsuo; Hidetoshi Masumoto; Shuhei Tajima; Akira Marui; Kenji Minakata; Tadashi Ikeda; Yasuhiko Tabata; Ryuzo Sakata; Jun K. Yamashita

  CIRCULATION, Nov. 2013, Peer-reviewed

  
• Prevention of retrosternal adhesion by novel biocompatible glue derived from food additives

  Tetsuya Kamitani; Hidetoshi Masumoto; Hirokazu Kotani; Tadashi Ikeda; Suong-Hyu Hyon; Ryuzo Sakata

  JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Nov. 2013, Peer-reviewed

  
• 自家静脈グラフトにおけるmicroRNA-145を用いた血管平滑筋制御

  大仲 玄明; 丸井 晃; 山原 研一; 南方 謙二; 山崎 和裕; 熊谷 基之; 升本 英利; 池田 義; 坂田 隆造

  日本血管外科学会雑誌, Apr. 2013

  
• Strategies in cell therapy for cardiac regeneration

  Masumoto Hidetoshi; Yamashita Jun K.

  Inflammation and Regeneration, 2013, Peer-reviewed, Lead author

  
• Cardiovascular surgery for realization of regenerative medicine

  Hidetoshi Masumoto; Ryuzo Sakata

  General Thoracic and Cardiovascular Surgery, Nov. 2012, Peer-reviewed, Lead author

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• Pluripotent Stem Cell-Engineered Cell Sheets Reassembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function Through Cardiomyocyte-Mediated Neovascularization

  Hidetoshi Masumoto; Takehiko Matsuo; Kohei Yamamizu; Hideki Uosaki; Genta Narazaki; Shiori Katayama; Akira Marui; Tatsuya Shimizu; Tadashi Ikeda; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita

  STEM CELLS, Jun. 2012, Peer-reviewed, Lead author

  
• Pluripotent stem cell-derived defined cardiac tissue sheets demonstrate cardiac repair through cardiomyocyte-mediated neovascularization

  升本英利; 山下潤

  Vol.11/No.4 : p56－62, 2012．日本再生医療学会, 2012, Peer-reviewed, Lead author

  
• A Case Report of Valve Dysfunction Associated with Abrasion of the Delrin Disk Used in Early Bjork-Shiley Mitral Valves Requiring Resurgery

  Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Nakai Masanao; Shoji Fujita; Yujiro Miura; Tatsuya Itonaga; Hiroki Ito

  ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, Apr. 2009, Peer-reviewed, Lead author, Corresponding author

  
• Airway stenosis associated with a mycotic pseudoaneurysm of the common carotid artery

  Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Masanao Nakai; Shoji Fujita; Yujiro Miura

  General Thoracic and Cardiovascular Surgery, May 2008, Peer-reviewed, Lead author, Corresponding author

  
• A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time

  Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Masanao Nakai; Shoji Fujita; Tatsuya Itonaga; Ryota Nomura

  Annals of Thoracic and Cardiovascular Surgery, Oct. 2007, Peer-reviewed, Lead author, Corresponding author

  
• Surgical treatment of thoracic aortic aneurysm in patients with concomitant coronary artery disease

  Masanao Nakai; Mitsuomi Shimamoto; Fumio Yamasaki; Shoji Fujita; Hidetoshi Masumoto; Tetsu Yamada; Daisuke Nakajima; Masatsugu Hamaji

  Japanese Journal of Thoracic and Cardiovascular Surgery, 2005, Peer-reviewed

  
• Two successful cases of coronary artery bypass grafting followed by transluminal carotid angioplasty with stenting

  T. Matsuo; T. Nishina; H. Masumoto; K. Tanbara; K. Ueyama; Y. Fujioka; M. Hanyu; T. Ikeda; K. Nishimura; M. Komeda

  Kyobu geka. The Japanese journal of thoracic surgery, 2001, Peer-reviewed

  

Misc.

• 開存バイパスグラフトを有する再開心術症例の検討

  岡本 実; 腰地 孝昭; 新井 善雄; 升本 英利; 幾野 毅

  Circulation Journal, 20 Apr. 2003

  
• 特発性血小板減少性紫斑病合併患者に対するCABG2治験例について

  岡本 実; 腰地 孝昭; 新井 善雄; 金 賢一; 升本 英利

  Circulation Journal, 20 Apr. 2002

  
• 下大静脈穿破を伴った腹部大動脈破裂の2例

  幾野 毅; 腰地 孝昭; 岡本 実; 新井 善雄; 塚下 将樹; 升本 英利

  日本血管外科学会雑誌, Jun. 2003

  
• 超高齢者(80歳以上)開心術後の遠隔期QOL

  新井 善雄; 腰地 孝昭; 岡本 実; 升本 英利; 幾野 毅; 坂田 隆造

  日本心臓血管外科学会雑誌, Apr. 2003

  
• 橈骨動脈グラフトの術前後での径変化についての検討

  升本 英利; 腰地 孝昭; 岡本 実; 新井 善雄; 幾野 毅

  日本心臓血管外科学会雑誌, Apr. 2003

  
• 上行弓部下行重複大動脈瘤一期的手術例

  岡本 実; 腰地 孝昭; 新井 善雄; 升本 英利

  The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2003

  
• 成人ASDの傾向と治療成績

  新井 善雄; 腰地 孝昭; 岡本 実; 升本 英利; 坂田 隆造

  The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2003

  
• 感染性ペースメーカーリードに対する開心術下摘出の2治験例

  升本 英利; 腰地 孝昭; 岡本 実; 新井 善雄; 金 賢一

  Circulation Journal, 20 Apr. 2002

  
• 橈骨動脈グラフト使用CABGの初期成績

  升本 英利; 腰地 孝昭; 岡本 実; 新井 善雄; 金 賢一

  The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2002

  
• 左冠動脈主幹部を含む冠動脈瘤の1治験例

  新井 善雄; 腰地 孝昭; 岡本 実; 金 賢一; 升本 英利; 斉藤 太郎

  Japanese Circulation Journal, 20 Oct. 2001

  
• 弓部分枝再建を要した胸部大動脈疾患に対する外科治療成績についての検討

  金 賢一; 坂田 隆造; 腰地 孝昭; 岡本 実; 新井 善雄; 升本 英利

  The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Sep. 2001

  
• 冠血行再建を伴う弁手術症例の中期遠隔期成績の検討

  新井 善雄; 坂田 隆造; 腰地 孝昭; 岡本 実; 金 賢一; 升本 英利

  日本心臓血管外科学会雑誌, Jan. 2001

  
• 体外循環にModificationを要した冠状動脈バイパス術の検討

  腰地 孝昭; 坂田 隆造; 岡本 実; 新井 善雄; 金 賢一; 升本 英利

  日本冠疾患学会雑誌, Nov. 2000

  
• 開存バイパスグラフトを有した弁膜症再手術症例の検討

  腰地 孝昭; 岡本 実; 新井 善雄; 升本 英利; 幾野 毅; 坂田 隆造

  日本心臓血管外科学会雑誌, Apr. 2003

  
• イメージング質量分析法を用いた拡張型心筋症ハムスターモデルのin depth組織プロテオーム解析

  新谷祈; 辻崇; 石田瑞希; 韮澤崇; 角田伸人; 植田初江; 升本英利; 湊谷謙司; 池川雅哉

  JSBMS Letters, 2019

  
• J2N-kハムスター拡張型心筋症モデルにおけるバイオマーカー探索および病態解明に向けたMALDIイメージング質量分析およびショットガンプロテオミクスの併用

  辻崇; 新谷祈; 石田瑞樹; 韮澤崇; 梶田遼; BRUNEVAL Patrick; 植田初江; 升本英利; 湊谷謙司; 池川雅哉

  日本胸部外科学会定期学術集会(Web), 2020

  
• Recombinant human soluble thrombomodulin prevents acute lung injury induced by cardiopulmonary bypass in rats

  S. Hirao; K. Minakata; H. Masumoto; M. Funamoto; S. Setozaki; K. Yamazaki; T. Ikeda; R. Sakata

  EUROPEAN HEART JOURNAL, Aug. 2016

  
• Therapeutic angiogenesis by local sustained release of microRNA-126 in murine hindlimb ischemia

  S. Tsumaru; K. Minakata; H. Masumoto; K. Ono; M. Izuhara; K. Yamazaki; T. Ikeda; R. Sakata

  EUROPEAN HEART JOURNAL, Aug. 2016

  
• Cardiac tissue sheet including human iPS cell-derived cardiomyocytes and vascular cells restores impaired left ventricular systolic function of infarcted porcine hearts: a preclinical study

  H. Masumoto; M. Ishigami; T. Aoki; F. Takai; T. Ikuno; M. Kawatoh; K. Minakata; T. Ikeda; R. Sakata; J. Yamashita

  EUROPEAN HEART JOURNAL, Aug. 2015

  
• Scalable and highly efficient endothelial cell differentiation methods from human induced pluripotent stem cells based on monolayer and serum-free culture

  T. Ikuno; H. Masumoto; A. Marui; K. Minakata; T. Ikeda; R. Sakata; J. K. Yamashita

  EUROPEAN HEART JOURNAL, Sep. 2014

  
• Efficient endothelial cell differentiation protocol from human induced pluripotent stem cells based on monolayer and serum-free culture for realization of vascular regenerative medicine

  T. Ikuno; H. Masumoto; A. Marui; T. Ikeda; R. Sakata; J. K. Yamashita

  EUROPEAN HEART JOURNAL, Aug. 2013

  
• Transplantation of cardiac tissue sheets including human induced pluripotent stem cell-derived defined cardiovascular cell populations ameliorates cardiac function after myocardial infarction

  H. Masumoto; T. Ikeda; T. Shimizu; T. Okano; R. Sakata; J. K. Yamashita

  EUROPEAN HEART JOURNAL, Aug. 2012

  
• Central role of cardiomyocytes in cell therapy: transplantation of cardiac tissue sheets with defined cell populations from pluripotent stem cells

  H. Masumoto; T. Shimizu; T. Ikeda; T. Okano; R. Sakata; J. K. Yamashita

  EUROPEAN HEART JOURNAL, Aug. 2011

  
• Differentiation toward cardiovascular cell populations from human iPS cells

  升本 英利; 山下 潤

  医学のあゆみ, 14 Mar. 2015

  
• Dissecting pathogenesis of dilated cardiomyopathy (DCM) on J2N-k Hamster model using MALDI-Imaging Mass Spectrometry in combination with shotgun proteomics

  新谷祈; 辻崇; 韮澤崇; 梶田遼; 植田初江; 升本英利; 湊谷謙司; 池川雅哉

  JSBMS Letters, 2020

  
• 拡張型心筋症モデルJ2-kハムスターおける病態解析:超高速イメージング質量分析法を用いた心筋組織プロテオームの視点から

  辻崇; 新谷祈; 石田瑞希; 韮澤崇; 植田初江; 池川雅哉; 升本英利; 湊谷謙司

  日本胸部外科学会定期学術集会(Web), 2019

  
• 拡張型心筋症ハムスターモデルの病態解析と超高速イメージング質量分析法を用いたプロテオミック・バイオマーカー探索

  新谷祈; 辻崇; 石田瑞希; 韮澤崇; 植田初江; 升本英利; 湊谷謙司; 池川雅哉

  JSBMS Letters, 2018

  
• 拡張型心筋症モデルJ2-kハムスターの発症機序に関する一考察:イメージング質量分析法を用いた心筋組織プロテオームの視点から

  辻崇; 新谷祈; 石田瑞希; 韮澤崇; 植田初江; 升本英利; 湊谷謙司; 池川雅哉

  日本血管生物医学会学術集会プログラム・抄録集, 2018

  
• Angiogenic Effects of Local Sustained Release of MicroRNA-126 in Murine Hindlimb Ischemia

  Shinichi Tsumaru; Kenji Minakata; Hidetoshi Masumoto; Koh Ono; Masayasu Izuhara; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata

  CIRCULATION, Nov. 2016

  
• Recombinant Human Soluble Thrombomodulin Prevents Acute Lung Injury in a Rat Cardiopulmonary Bypass Model

  Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Shuji Setozaki; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata

  CIRCULATION, Nov. 2016

  
• Recombinant Human Soluble Thrombomodulin Prevents Acute Lung Injury in a Rat Cardiopulmonary Bypass Model

  Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Shuji Setozaki; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata

  CIRCULATION, Nov. 2016

  
• Human iPS cell-engineered 3D-cardiovascular tissue by stacking sheets with gelatin hydrogel microspheres for cardiac regenerative medicine

  K. Yamamizu; T. Ikuno; H. Takakubo; H. Masumoto; K. Minakata; Y. Tabata; J. K. Yamashita

  EUROPEAN HEART JOURNAL, Aug. 2016

  
• A Novel Method to Therapeutic Angiogenesis by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel Sheet in a Canine Chronic Myocardial Infarction Model

  Motoyuki Kumagai; Akira Marui; Yasuhiko Tabata; Eiji Yoshikawa; Masaya Yamamoto; Atsushi Yonezawa; Shiro Tanaka; Takafumi Ikeda; Hidetoshi Masumoto; Tomohiro Nakata; Hisashi Sakaguchi; Kenji Minakata; Kazuhiro Yamazaki; Tadasi Ikeda; Masayuki Yokode; Akira Shimizu; Ryuzo Sakata

  CIRCULATION, Nov. 2014

  
• Cell sheet transplantation to rat infarct heart using genomic integration-free human ips cells generated with episomal plasmid vectors: A strategy for tumor-free cardiac cell therapy

  Masumoto H; Ikuno T; Okita K; Marui A; Minakata K; Ikeda T; Sakata R; Yamashita J

  ISSCR 12th Annual Meeting, Jun. 2014, Peer-reviewed

  
• PD-1-6 多能性幹細胞由来心臓組織シート移植 : 心筋組織再生を目指して(PD-1 パネルディスカッション(1)細胞・臓器移植における基礎的研究の最前線,第114回日本外科学会定期学術集会)

  松尾 武彦; 升本 英利; 丸井 晃; 南方 謙二; 池田 義; 山下 潤; 坂田 隆造

  日本外科学会雑誌, 05 Mar. 2014

  
• SY-7-7 細胞シート技術を用いた多能性幹細胞による心筋再生研究 : 機能的再生から組織再生へ(SY シンポジウム,第113回日本外科学会定期学術集会)

  升本 英利; 南方 謙二; 丸井 晃; 池田 義; 清水 達也; 岡野 光夫; 山下 潤; 坂田 隆造

  日本外科学会雑誌, 05 Mar. 2013

  
• Transplantation of Cell Sheets with Human iPS Cell-derived Cardiomyocytes and Vascular Cells for Infarcted Hearts: A Basic Study

  Hidetoshi Masumoto; Akira Marui; Tadashi Ikeda; Tatsuya Shimizu; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita

  CIRCULATION, Nov. 2012

  
• Transplantation of Cardiac Tissue Sheets Including Defined Cardiovascular Cell Populations Differentiated from Human-Induced Pluripotent Stem Cells Ameliorates Cardiac Dysfunction After Subacute Myocardial Infarction

  Hidetoshi Masumoto; Tadashi Ikeda; Tatsuya Shimizu; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita

  CIRCULATION RESEARCH, Aug. 2012

  

Awards

• 09 Jun. 2012

  第12回比叡山ﾜｰｸｼｮｯﾌﾟ最優秀賞(基礎研究部門)(京都大学医学部心臓血管外科同門会)
• 03 Jun. 2011

  The Japanese Society of Inflammation and Regeneration, Poster Award, The 32nd Annual Meeting of Japanese Society of Inflammation and Regeneration
• 14 Jun. 2012

  The Japanese Society for Regenerative Medicine, The most excellent prize, Basic research, The 4th Young Investigator’s Award, Japanese Society for Regenerative Medicine
• 06 Jul. 2012

  The Japanese Society of Inflammation and Regeneration, The best poster award, The 33rd Annual Meeting of Japanese Society of Inflammation and Regeneration
• 15 Feb. 2013

  Miyazaki Science Camp, Excellent prize, The 9th Miyazaki Science Camp
• 12 Feb. 2019

  The Japanese Society for Cardiovascular Surgery, Most excellent prize, The 49th Annual Meeting of the Japanese Society for Cardiovascular Surgery

External funds: others

• Novartis Pharma AG, NIBR Global Scholars Program

  From 01 Jan. 2023, To 31 Dec. 2025

  Hidetoshi Masumoto
• Study of a newly designed high-performance membrane oxygenator equipped with both local temperature control technology and non-fouling technology

  日本医療研究開発機構（AMED）医療分野研究成果展開事業先端計測分析技術・機器開発プログラム

  From 22 Jun. 2020, To 31 Mar. 2023

  織田　禎二
• Study of immunological rejection related to iPS cell-derived artificial heart tissue transplantation for cardiac regenerative medicine

  日本医療研究開発機構（AMED）再生医療実現拠点ネットワークプログラム（技術開発個別課題）

  From 01 Oct. 2018, To 31 Mar. 2021

  湊谷　謙司
• Development of a new surgical device for less-invasive transplantation of iPS cell-derived cardiac tissues

  京都大学産官学連携本部　GAPファンドプログラム

  From 01 Mar. 2019, To 29 Feb. 2020

  升本　英利
• Research for identification of pathology-associated biomarkers of dilated cardiomyopathy model hamsters

  材料科学技術振興財団　共同研究

  From 01 Jan. 2019, To 31 Dec. 2019

  升本　英利
• Development of technologies to establish functional tissue based on tissue engineering

  日本医療研究開発機構(AMED)　未来医療を実現する医療機器・システム研究開発事業

  From 01 Apr. 2018, To 31 Mar. 2019

  田畑　泰彦