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Masumoto, Hidetoshi

KYOTO UNIVERSITY HOSPITAL Program-Specific Associate Professor

Masumoto, Hidetoshi
list
    Last Updated :2024/05/11

    Basic Information

    Academic Degree

    • 24 Sep. 2012
      京都大学博士(医学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院医学研究科博士課程医学専攻, 修了
    • 京都大学, 大学院医学研究科博士課程医学専攻, 研究指導認定退学

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 医学部医学科, 卒業

    Research History

    • From Jul. 2023, To Present
      京都大学医学部附属病院, 心臓血管外科, 特定准教授
    • From Apr. 2018, To Present
      理化学研究所生命機能科学研究センター(組織改組に伴う名称変更), 臨床橋渡しプログラム・升本研究室, 研究リーダー
    • From Oct. 2017, To Mar. 2023
      京都大学医学部附属病院, 心臓血管外科, 特定助教
    • From Oct. 2017, To Mar. 2018
      理化学研究所多細胞システム形成研究センター, 臨床橋渡しプログラム・升本研究室, 研究リーダー
    • From Oct. 2016, To Sep. 2017
      京都大学医学部附属病院, 心臓血管外科, 助教
    • From Sep. 2015, To Sep. 2016
      Kyoto University, iPS細胞研究所(CiRA), 特定研究員(特命助教)
    • From Sep. 2013, To Aug. 2015
      米国Louisville大学, Cardiovascular Innovation Institute, 博士研究員
    • From May 2012, To Aug. 2013
      京都大学医学部附属病院, 心臓血管外科, 特定病院助教
    • From Nov. 2002, To Apr. 2008
      静岡市立静岡病院, 心臓血管外科, 医員
    • From Mar. 2000, To Oct. 2002
      国家公務員共済組合連合会 熊本中央病院, 心臓血管外科, 医員
    • From May 1999, To Feb. 2000
      Kyoto University Hospital, Department of Cardiovascular Surgery, 研修医

    Language of Instruction

    • Japanese
    • English

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2024/05/11

      Research

      Research Topics, Overview of the research

      • Research Topics

        Regenerative medicine in cardiovascular surgery
      • Overview of the research

        Generation of human iPS cell-derived 3-dimensional cardiac tissue and the clinical application

      Research Interests

      • Tissue engineering
      • Stem cell biology
      • Clinical translational research
      • Cardiology
      • Cardiovascular surgery
      • Regenerative medicine

      Research Areas

      • Life sciences, Cardiovascular surgery

      Papers

      • ヒトiPS細胞由来の薬剤誘発性Torsade de Pointes再現心臓組織モデル
        川東 正英; 升本 英利; 森永 学; 芦原 貴司; 山下 潤
        日本内分泌学会雑誌, Dec. 2018
      • Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model.
        Kozue Murata; Akiko Makino; Keizo Tomonaga; Hidetoshi Masumoto
        iScience, 19 Jan. 2024, Peer-reviewed, Last author, Corresponding author
      • Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device.
        Daisuke Heima; Masafumi Takeda; Yasuhiko Tabata; Kenji Minatoya; Jun K Yamashita; Hidetoshi Masumoto
        The Journal of thoracic and cardiovascular surgery, 21 Nov. 2023, Peer-reviewed, Last author, Corresponding author
      • 拡張型心筋症モデルハムスターの網羅的代謝イメージング解析
        岡邑 舞子; 山口 真一; 山本 卓志; 袴田 圭祐; 新谷 祈; 辻 崇; 植田 初江; 雨宮 妃; 湊谷 謙司; 升本 英利; 池川 雅哉
        JSBMS Letters, Aug. 2022
      • Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.
        Shoichi Kyo; Kozue Murata; Masahide Kawatou; Kenji Minatoya; Genshiro A Sunagawa; Hidetoshi Masumoto
        JTCVS open, Dec. 2022, Peer-reviewed, Last author, Corresponding author
      • A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture
        Wen-Jin Ho; Mako Kobayashi; Kozue Murata; Yoshihide Hashimoto; Kenji Izumi; Tsuyoshi Kimura; Hideo Kanemitsu; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto
        Scientific Reports, 24 Dec. 2022, Peer-reviewed, Last author, Corresponding author
      • 拡張型心筋症モデルハムスターの網羅的代謝イメージング解析
        岡邑 舞子; 山口 真一; 山本 卓志; 袴田 圭祐; 新谷 祈; 辻 崇; 植田 初江; 雨宮 妃; 湊谷 謙司; 升本 英利; 池川 雅哉
        JSBMS Letters, Aug. 2022
      • Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction.
        Yasushi Konegawa; Toshie Kuwahara; Jun-Ichiro Jo; Kozue Murata; Takahide Takeda; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto; Yasuhiko Tabata
        European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 10 Aug. 2022, Peer-reviewed, Corresponding author
      • Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells.
        Kozue Murata; Hidetoshi Masumoto
        Stem cells (Dayton, Ohio), 22 Jun. 2022, Peer-reviewed, Last author, Corresponding author
      • Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models.
        Yasue Fujiwara; Shingo Hirao; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto
        Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, Mar. 2022, Peer-reviewed, Last author, Corresponding author
      • Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues
        Hiroaki Osada; Masahide Kawatou; Daiki Fujita; Yasuhiko Tabata; Kenji Minatoya; Jun K. Yamashita; Hidetoshi Masumoto
        JTCVS Open, Dec. 2021, Peer-reviewed, Last author, Corresponding author
      • In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model
        Shunji Kurokawa; Yoshihide Hashimoto; Seiichi Funamoto; Kozue Murata; Akitatsu Yamashita; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto
        PLOS ONE, 22 Jul. 2021, Peer-reviewed, Last author, Corresponding author
      • Generation of Cylindrical Engineered Cardiac Tissues from Human iPS Cell-Derived Cardiovascular Cell Lineages.
        Hidetoshi Masumoto
        Methods in molecular biology (Clifton, N.J.), 2021, Peer-reviewed, Lead author, Corresponding author
      • Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
        Marc Dwenger; William J. Kowalski; Hidetoshi Masumoto; Takeichiro Nakane; Bradley B. Keller
        Methods in Molecular Biology, 2021, Peer-reviewed
      • Strategies for immune regulation in iPS cell-based cardiac regenerative medicine
        Kozue Murata; Masaya Ikegawa; Kenji Minatoya; Hidetoshi Masumoto
        Inflammation and Regeneration, Dec. 2020, Peer-reviewed, Last author, Corresponding author
      • Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
        Mosha Abulaiti; Yaxiaer Yalikun; Kozue Murata; Asako Sato; Mustafa M. Sami; Yuko Sasaki; Yasue Fujiwara; Kenji Minatoya; Yuji Shiba; Yo Tanaka; Hidetoshi Masumoto
        Scientific Reports, Dec. 2020, Peer-reviewed, Last author, Corresponding author
      • Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator
        Hiroaki Osada; Wen-Jin Ho; Hideki Yamashita; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto
        Regenerative Therapy, Dec. 2020, Peer-reviewed, Last author, Corresponding author
      • The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model
        Tatsuya Itonaga; Shingo Hirao; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto
        General Thoracic and Cardiovascular Surgery, Aug. 2020, Peer-reviewed, Last author, Corresponding author
      • Management of retrosternal adhesion after median sternotomy by controlling degradation speed of a dextran and ε-poly (l-lysine)-based biocompatible glue
        Fumie Takai; Takahide Takeda; Kazuhiro Yamazaki; Tadashi Ikeda; Suong-Hyu Hyon; Kenji Minatoya; Hidetoshi Masumoto
        General Thoracic and Cardiovascular Surgery, Aug. 2020, Peer-reviewed, Last author, Corresponding author
      • Accuracy of spiked cell counting methods for designing a pre-clinical tumorigenicity study model.
        Hiroaki Osada; Masahide Kawatou; Masafumi Takeda; Jun-Ichiro Jo; Takashi Murakami; Yasuhiko Tabata; Kenji Minatoya; Jun K Yamashita; Hidetoshi Masumoto
        Heliyon, Jul. 2020, Peer-reviewed, Last author, Corresponding author
      • Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair
        Takeichiro Nakane; Mosha Abulaiti; Yuko Sasaki; William J. Kowalski; Bradley B. Keller; Hidetoshi Masumoto
        Journal of Visualized Experiments, 09 Jun. 2020, Peer-reviewed, Last author, Corresponding author
      • A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure
        Hiroomi Nishio; Kenji Minatoya; Hidetoshi Masumoto
        Journal of Visualized Experiments, 15 May 2020, Peer-reviewed, Last author, Corresponding author
      • Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model.
        Atsushi Nagasawa; Hidetoshi Masumoto; Shigeki Yanagi; Naoki Kanemitsu; Tadashi Ikeda; Yasuhiko Tabata; Kenji Minatoya
        General thoracic and cardiovascular surgery, Apr. 2020, Peer-reviewed
      • Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues
        Marc Dwenger; William J Kowalski; Fei Ye; Fangping Yuan; Joseph P Tinney; Shuji Setozaki; Takeichiro Nakane; Hidetoshi Masumoto; Peter Campbell; William Guido; Bradley B Keller
        Journal of Tissue Engineering, Jan. 2019, Peer-reviewed
      • Development of a bioassay system to evaluate the pulsatile function of human heart tissue using a cellular micropump on-chip and a biomimetic human iPS cell-derived heart tissue sheet technology
        Abulaiti Mosha; Kozue Murata; Yalikun Yaxiaer; Yo Tanaka; Hidetoshi Masumoto
        Proceeding of Micro Total Analysis Systems 2018, Nov. 2018, Peer-reviewed, Last author, Corresponding author
      • Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model.
        Li Z; Masumoto H; Jo JI; Yamazaki K; Ikeda T; Tabata Y; Minatoya K
        General thoracic and cardiovascular surgery, Nov. 2018, Peer-reviewed, Corresponding author
      • MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model.
        Nishio H; Masumoto H; Sakamoto K; Yamazaki K; Ikeda T; Minatoya K
        The Journal of thoracic and cardiovascular surgery, Oct. 2018, Peer-reviewed, Corresponding author
      • Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia.
        Tsumaru S; Masumoto H; Minakata K; Izuhara M; Yamazaki K; Ikeda T; Ono K; Sakata R; Minatoya K
        Journal of vascular surgery, Oct. 2018, Peer-reviewed, Corresponding author
      • 拡張型心筋症ハムスターモデルの病態解析と超高速イメージング質量分析法を用いたプロテオミック・バイオマーカー探索
        新谷 祈; 辻 崇; 石田 瑞希; 韮澤 崇; 植田 初江; 升本 英利; 湊谷 謙司; 池川 雅哉
        JSBMS Letters, Aug. 2018
      • A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model
        Motoyuki Kumagai; Kenji Minakata; Hidetoshi Masumoto; Masaya Yamamoto; Atsushi Yonezawa; Takafumi Ikeda; Kyokun Uehara; Kazuhiro Yamazaki; Tadashi Ikeda; Kazuo Matsubara; Masayuki Yokode; Akira Shimizu; Yasuhiko Tabata; Ryuzo Sakata; Kenji Minatoya
        Heart and Vessels, 14 May 2018, Peer-reviewed, Corresponding author
      • A recovery cardiopulmonary bypass model without transfusion or inotropic agents in rats
        Shingo Hirao; Hidetoshi Masumoto; Tatsuya Itonaga; Kenji Minatoya
        Journal of Visualized Experiments, 20 Mar. 2018, Peer-reviewed, Corresponding author
      • Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82
        Masafumi Takeda; Yasuharu Kanki; Hidetoshi Masumoto; Shunsuke Funakoshi; Takeshi Hatani; Hiroyuki Fukushima; Akashi Izumi-Taguchi; Yusuke Matsui; Teppei Shimamura; Yoshinori Yoshida; Jun K. Yamashita
        Cell Reports, 2018, Peer-reviewed
      • Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts.
        Ishigami M; Masumoto H; Ikuno T; Aoki T; Kawatou M; Minakata K; Ikeda T; Sakata R; Yamashita JK; Minatoya K
        PloS one, 2018, Peer-reviewed, Corresponding author
      • Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft.
        Masumoto H; Yamashita JK
        Inflammation and regeneration, 2018, Peer-reviewed, Lead author, Corresponding author
      • Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model
        Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Ryuzo Sakata
        JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Dec. 2017, Peer-reviewed, Corresponding author
      • Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
        Masahide Kawatou; Hidetoshi Masumoto; Hiroyuki Fukushima; Gaku Morinaga; Ryuzo Sakata; Takashi Ashihara; Jun K. Yamashita
        NATURE COMMUNICATIONS, Oct. 2017, Peer-reviewed
      • Quantification of Cardiomyocyte Alignment from Three-Dimensional (3D) Confocal Microscopy of Engineered Tissue
        William J. Kowalski; Fangping Yuan; Takeichiro Nakane; Hidetoshi Masumoto; Marc Dwenger; Fei Ye; Joseph P. Tinney; Bradley B. Keller
        MICROSCOPY AND MICROANALYSIS, Aug. 2017, Peer-reviewed
      • Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model
        Shuji Setozaki; Kenji Minakata; Hidetoshi Masumoto; Shingo Hirao; Kazuhiro Yamazaki; Koichiro Kuwahara; Tadashi Ikeda; Ryuzo Sakata
        JOURNAL OF VASCULAR SURGERY, Jun. 2017, Peer-reviewed
      • Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017)
        Takeshi Ikuno; Hidetoshi Masumoto; Kohei Yamamizu; Miki Yoshioka; Kenji Minakata; Tadashi Ikeda; Ryuzo Sakata; Jun K. Yamashita
        PLOS ONE, Apr. 2017, Peer-reviewed
      • Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue
        Takeichiro Nakane; Hidetoshi Masumoto; Joseph P. Tinney; Fangping Yuan; William J. Kowalski; Fei Ye; Amanda J. LeBlanc; Ryuzo Sakata; Jun K. Yamashita; Bradley B. Keller
        SCIENTIFIC REPORTS, Apr. 2017, Peer-reviewed
      • Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017)
        Takeshi Ikuno; Hidetoshi Masumoto; Kohei Yamamizu; Miki Yoshioka; Kenji Minakata; Tadashi Ikeda; Ryuzo Sakata; Jun K. Yamashita
        PLOS ONE, Apr. 2017, Peer-reviewed
      • Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model
        Tomofumi Taki; Hidetoshi Masumoto; Masaki Funamoto; Kenji Minakata; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
        JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2017, Peer-reviewed, Corresponding author
      • Untiring steps toward the maturation of human stem cell-engineered heart tissue
        Hidetoshi Masumoto; Jun K. Yamashita
        Annals of Translational Medicine, 01 Feb. 2017, Peer-reviewed, Lead author, Corresponding author
      • Therapeutic angiogenesis with growth factor using drug delivery system in cardiovascular medicine
        Kenji Minakata; Hiroomi Nishio; Hidetoshi Masumoto; Ryuzo Sakata
        Drug Delivery System, 2017, Peer-reviewed
      • Human iPS Cell-Derived Cardiac Tissue Sheets: a Platform for Cardiac Regeneration
        Hidetoshi Masumoto; Jun K. Yamashita
        Current Treatment Options in Cardiovascular Medicine, 01 Nov. 2016, Peer-reviewed, Lead author, Corresponding author
      • The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages
        Hidetoshi Masumoto; Takeichiro Nakane; Joseph P. Tinney; Fangping Yuan; Fei Ye; William J. Kowalski; Kenji Minakata; Ryuzo Sakata; Jun K. Yamashita; Bradley B. Keller
        SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed, Lead author
      • Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass
        Masaki Funamoto; Hidetoshi Masumoto; Koji Takaori; Tomofumi Taki; Shuji Setozaki; Kazuhiro Yamazaki; Kenji Minakata; Tadashi Ikeda; Suong-Hyu Hyon; Ryuzo Sakata
        ANNALS OF THORACIC SURGERY, Apr. 2016, Peer-reviewed
      • Exploiting human iPS cell-derived cardiovascular cell populations toward cardiac regenerative therapy.
        Masumoto H; Yamashita JK
        Stem Cell Transl Investig, 2016, Peer-reviewed, Lead author, Corresponding author
      • Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes
        Keller BB; Ye F; Yuan F; Trada H; Tinney JP; Walsh KM; Masumoto H; Nakanishi T; Markwald RR; Baldwin HS; Keller BB; Srivastava D; Yamagishi H
        2016, Peer-reviewed
      • ブタ心筋梗塞モデルを用いたiPS細胞由来心臓組織シート移植による不整脈評価実験
        幾野 毅; 青木 隆之; 升本 英利; 小原 浩; 中村 裕二; 中瀬古 寛子; 安東 賢太郎; 川東 正英; 石上 雅之助; 南方 謙二; 池田 義; 杉山 篤; 山下 潤; 坂田 隆造
        日本バイオマテリアル学会大会予稿集, Nov. 2015
      • Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells
        Takehiko Matsuo; Hidetoshi Masumoto; Shuhei Tajima; Takeshi Ikuno; Shiori Katayama; Kenji Minakata; Tadashi Ikeda; Kohei Yamamizu; Yasuhiko Tabata; Ryuzo Sakata; Jun K. Yamashita
        SCIENTIFIC REPORTS, Nov. 2015, Peer-reviewed
      • Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration
        Hidetoshi Masumoto; Takeshi Ikuno; Masafumi Takeda; Hiroyuki Fukushima; Akira Marui; Shiori Katayama; Tatsuya Shimizu; Tadashi Ikeda; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
        SCIENTIFIC REPORTS, Oct. 2014, Peer-reviewed, Lead author
      • Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype
        Motoaki Ohnaka; Akira Marui; Kenichi Yamahara; Kenji Minakata; Kazuhiro Yamazaki; Motoyuki Kumagai; Hidetoshi Masumoto; Shiro Tanaka; Tadashi Ikeda; Ryuzo Sakata
        JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Aug. 2014, Peer-reviewed
      • Effects of hepatocyte growth factor in myocarditis rats induced by immunization with porcine cardiac myosin
        Jota Nakano; Akira Marui; Hiroyuki Muranaka; Hidetoshi Masumoto; Hisashi Noma; Yasuhiko Tabata; Akio Ido; Hirohito Tsubouchi; Tadashi Ikeda; Ryuzo Sakata
        INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Mar. 2014, Peer-reviewed
      • Efficiently Piled-Up Cardiac Tissue-Like Sheets With Pluripotent Stem Cell-Derived Cells Robustly Promotes Cell Engraftment and Ameliorates Cardiac Dysfunction After Myocardial Infarction
        Takehiko Matsuo; Hidetoshi Masumoto; Shuhei Tajima; Akira Marui; Kenji Minakata; Tadashi Ikeda; Yasuhiko Tabata; Ryuzo Sakata; Jun K. Yamashita
        CIRCULATION, Nov. 2013, Peer-reviewed
      • Prevention of retrosternal adhesion by novel biocompatible glue derived from food additives
        Tetsuya Kamitani; Hidetoshi Masumoto; Hirokazu Kotani; Tadashi Ikeda; Suong-Hyu Hyon; Ryuzo Sakata
        JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Nov. 2013, Peer-reviewed
      • 自家静脈グラフトにおけるmicroRNA-145を用いた血管平滑筋制御
        大仲 玄明; 丸井 晃; 山原 研一; 南方 謙二; 山崎 和裕; 熊谷 基之; 升本 英利; 池田 義; 坂田 隆造
        日本血管外科学会雑誌, Apr. 2013
      • Strategies in cell therapy for cardiac regeneration
        Masumoto Hidetoshi; Yamashita Jun K.
        Inflammation and Regeneration, 2013, Peer-reviewed, Lead author
      • Cardiovascular surgery for realization of regenerative medicine
        Hidetoshi Masumoto; Ryuzo Sakata
        General Thoracic and Cardiovascular Surgery, Nov. 2012, Peer-reviewed, Lead author
      • Pluripotent Stem Cell-Engineered Cell Sheets Reassembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function Through Cardiomyocyte-Mediated Neovascularization
        Hidetoshi Masumoto; Takehiko Matsuo; Kohei Yamamizu; Hideki Uosaki; Genta Narazaki; Shiori Katayama; Akira Marui; Tatsuya Shimizu; Tadashi Ikeda; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
        STEM CELLS, Jun. 2012, Peer-reviewed, Lead author
      • Pluripotent stem cell-derived defined cardiac tissue sheets demonstrate cardiac repair through cardiomyocyte-mediated neovascularization
        升本英利; 山下潤
        Vol.11/No.4 : p56-62, 2012.日本再生医療学会, 2012, Peer-reviewed, Lead author
      • A Case Report of Valve Dysfunction Associated with Abrasion of the Delrin Disk Used in Early Bjork-Shiley Mitral Valves Requiring Resurgery
        Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Nakai Masanao; Shoji Fujita; Yujiro Miura; Tatsuya Itonaga; Hiroki Ito
        ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, Apr. 2009, Peer-reviewed, Lead author, Corresponding author
      • Airway stenosis associated with a mycotic pseudoaneurysm of the common carotid artery
        Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Masanao Nakai; Shoji Fujita; Yujiro Miura
        General Thoracic and Cardiovascular Surgery, May 2008, Peer-reviewed, Lead author, Corresponding author
      • A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time
        Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Masanao Nakai; Shoji Fujita; Tatsuya Itonaga; Ryota Nomura
        Annals of Thoracic and Cardiovascular Surgery, Oct. 2007, Peer-reviewed, Lead author, Corresponding author
      • Surgical treatment of thoracic aortic aneurysm in patients with concomitant coronary artery disease
        Masanao Nakai; Mitsuomi Shimamoto; Fumio Yamasaki; Shoji Fujita; Hidetoshi Masumoto; Tetsu Yamada; Daisuke Nakajima; Masatsugu Hamaji
        Japanese Journal of Thoracic and Cardiovascular Surgery, 2005, Peer-reviewed
      • Two successful cases of coronary artery bypass grafting followed by transluminal carotid angioplasty with stenting
        T. Matsuo; T. Nishina; H. Masumoto; K. Tanbara; K. Ueyama; Y. Fujioka; M. Hanyu; T. Ikeda; K. Nishimura; M. Komeda
        Kyobu geka. The Japanese journal of thoracic surgery, 2001, Peer-reviewed

      Misc.

      • 開存バイパスグラフトを有する再開心術症例の検討
        岡本 実; 腰地 孝昭; 新井 善雄; 升本 英利; 幾野 毅
        Circulation Journal, 20 Apr. 2003
      • 特発性血小板減少性紫斑病合併患者に対するCABG2治験例について
        岡本 実; 腰地 孝昭; 新井 善雄; 金 賢一; 升本 英利
        Circulation Journal, 20 Apr. 2002
      • 下大静脈穿破を伴った腹部大動脈破裂の2例
        幾野 毅; 腰地 孝昭; 岡本 実; 新井 善雄; 塚下 将樹; 升本 英利
        日本血管外科学会雑誌, Jun. 2003
      • 超高齢者(80歳以上)開心術後の遠隔期QOL
        新井 善雄; 腰地 孝昭; 岡本 実; 升本 英利; 幾野 毅; 坂田 隆造
        日本心臓血管外科学会雑誌, Apr. 2003
      • 橈骨動脈グラフトの術前後での径変化についての検討
        升本 英利; 腰地 孝昭; 岡本 実; 新井 善雄; 幾野 毅
        日本心臓血管外科学会雑誌, Apr. 2003
      • 上行弓部下行重複大動脈瘤一期的手術例
        岡本 実; 腰地 孝昭; 新井 善雄; 升本 英利
        The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2003
      • 成人ASDの傾向と治療成績
        新井 善雄; 腰地 孝昭; 岡本 実; 升本 英利; 坂田 隆造
        The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2003
      • 感染性ペースメーカーリードに対する開心術下摘出の2治験例
        升本 英利; 腰地 孝昭; 岡本 実; 新井 善雄; 金 賢一
        Circulation Journal, 20 Apr. 2002
      • 橈骨動脈グラフト使用CABGの初期成績
        升本 英利; 腰地 孝昭; 岡本 実; 新井 善雄; 金 賢一
        The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2002
      • 左冠動脈主幹部を含む冠動脈瘤の1治験例
        新井 善雄; 腰地 孝昭; 岡本 実; 金 賢一; 升本 英利; 斉藤 太郎
        Japanese Circulation Journal, 20 Oct. 2001
      • 弓部分枝再建を要した胸部大動脈疾患に対する外科治療成績についての検討
        金 賢一; 坂田 隆造; 腰地 孝昭; 岡本 実; 新井 善雄; 升本 英利
        The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Sep. 2001
      • 冠血行再建を伴う弁手術症例の中期遠隔期成績の検討
        新井 善雄; 坂田 隆造; 腰地 孝昭; 岡本 実; 金 賢一; 升本 英利
        日本心臓血管外科学会雑誌, Jan. 2001
      • 体外循環にModificationを要した冠状動脈バイパス術の検討
        腰地 孝昭; 坂田 隆造; 岡本 実; 新井 善雄; 金 賢一; 升本 英利
        日本冠疾患学会雑誌, Nov. 2000
      • 開存バイパスグラフトを有した弁膜症再手術症例の検討
        腰地 孝昭; 岡本 実; 新井 善雄; 升本 英利; 幾野 毅; 坂田 隆造
        日本心臓血管外科学会雑誌, Apr. 2003
      • イメージング質量分析法を用いた拡張型心筋症ハムスターモデルのin depth組織プロテオーム解析
        新谷祈; 辻崇; 石田瑞希; 韮澤崇; 角田伸人; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
        JSBMS Letters, 2019
      • J2N-kハムスター拡張型心筋症モデルにおけるバイオマーカー探索および病態解明に向けたMALDIイメージング質量分析およびショットガンプロテオミクスの併用
        辻崇; 新谷祈; 石田瑞樹; 韮澤崇; 梶田遼; BRUNEVAL Patrick; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
        日本胸部外科学会定期学術集会(Web), 2020
      • Recombinant human soluble thrombomodulin prevents acute lung injury induced by cardiopulmonary bypass in rats
        S. Hirao; K. Minakata; H. Masumoto; M. Funamoto; S. Setozaki; K. Yamazaki; T. Ikeda; R. Sakata
        EUROPEAN HEART JOURNAL, Aug. 2016
      • Therapeutic angiogenesis by local sustained release of microRNA-126 in murine hindlimb ischemia
        S. Tsumaru; K. Minakata; H. Masumoto; K. Ono; M. Izuhara; K. Yamazaki; T. Ikeda; R. Sakata
        EUROPEAN HEART JOURNAL, Aug. 2016
      • Cardiac tissue sheet including human iPS cell-derived cardiomyocytes and vascular cells restores impaired left ventricular systolic function of infarcted porcine hearts: a preclinical study
        H. Masumoto; M. Ishigami; T. Aoki; F. Takai; T. Ikuno; M. Kawatoh; K. Minakata; T. Ikeda; R. Sakata; J. Yamashita
        EUROPEAN HEART JOURNAL, Aug. 2015
      • Scalable and highly efficient endothelial cell differentiation methods from human induced pluripotent stem cells based on monolayer and serum-free culture
        T. Ikuno; H. Masumoto; A. Marui; K. Minakata; T. Ikeda; R. Sakata; J. K. Yamashita
        EUROPEAN HEART JOURNAL, Sep. 2014
      • Efficient endothelial cell differentiation protocol from human induced pluripotent stem cells based on monolayer and serum-free culture for realization of vascular regenerative medicine
        T. Ikuno; H. Masumoto; A. Marui; T. Ikeda; R. Sakata; J. K. Yamashita
        EUROPEAN HEART JOURNAL, Aug. 2013
      • Transplantation of cardiac tissue sheets including human induced pluripotent stem cell-derived defined cardiovascular cell populations ameliorates cardiac function after myocardial infarction
        H. Masumoto; T. Ikeda; T. Shimizu; T. Okano; R. Sakata; J. K. Yamashita
        EUROPEAN HEART JOURNAL, Aug. 2012
      • Central role of cardiomyocytes in cell therapy: transplantation of cardiac tissue sheets with defined cell populations from pluripotent stem cells
        H. Masumoto; T. Shimizu; T. Ikeda; T. Okano; R. Sakata; J. K. Yamashita
        EUROPEAN HEART JOURNAL, Aug. 2011
      • Differentiation toward cardiovascular cell populations from human iPS cells
        升本 英利; 山下 潤
        医学のあゆみ, 14 Mar. 2015
      • Dissecting pathogenesis of dilated cardiomyopathy (DCM) on J2N-k Hamster model using MALDI-Imaging Mass Spectrometry in combination with shotgun proteomics
        新谷祈; 辻崇; 韮澤崇; 梶田遼; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
        JSBMS Letters, 2020
      • 拡張型心筋症モデルJ2-kハムスターおける病態解析:超高速イメージング質量分析法を用いた心筋組織プロテオームの視点から
        辻崇; 新谷祈; 石田瑞希; 韮澤崇; 植田初江; 池川雅哉; 升本英利; 湊谷謙司
        日本胸部外科学会定期学術集会(Web), 2019
      • 拡張型心筋症ハムスターモデルの病態解析と超高速イメージング質量分析法を用いたプロテオミック・バイオマーカー探索
        新谷祈; 辻崇; 石田瑞希; 韮澤崇; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
        JSBMS Letters, 2018
      • 拡張型心筋症モデルJ2-kハムスターの発症機序に関する一考察:イメージング質量分析法を用いた心筋組織プロテオームの視点から
        辻崇; 新谷祈; 石田瑞希; 韮澤崇; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
        日本血管生物医学会学術集会プログラム・抄録集, 2018
      • Angiogenic Effects of Local Sustained Release of MicroRNA-126 in Murine Hindlimb Ischemia
        Shinichi Tsumaru; Kenji Minakata; Hidetoshi Masumoto; Koh Ono; Masayasu Izuhara; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
        CIRCULATION, Nov. 2016
      • Recombinant Human Soluble Thrombomodulin Prevents Acute Lung Injury in a Rat Cardiopulmonary Bypass Model
        Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Shuji Setozaki; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
        CIRCULATION, Nov. 2016
      • Recombinant Human Soluble Thrombomodulin Prevents Acute Lung Injury in a Rat Cardiopulmonary Bypass Model
        Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Shuji Setozaki; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
        CIRCULATION, Nov. 2016
      • Human iPS cell-engineered 3D-cardiovascular tissue by stacking sheets with gelatin hydrogel microspheres for cardiac regenerative medicine
        K. Yamamizu; T. Ikuno; H. Takakubo; H. Masumoto; K. Minakata; Y. Tabata; J. K. Yamashita
        EUROPEAN HEART JOURNAL, Aug. 2016
      • A Novel Method to Therapeutic Angiogenesis by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel Sheet in a Canine Chronic Myocardial Infarction Model
        Motoyuki Kumagai; Akira Marui; Yasuhiko Tabata; Eiji Yoshikawa; Masaya Yamamoto; Atsushi Yonezawa; Shiro Tanaka; Takafumi Ikeda; Hidetoshi Masumoto; Tomohiro Nakata; Hisashi Sakaguchi; Kenji Minakata; Kazuhiro Yamazaki; Tadasi Ikeda; Masayuki Yokode; Akira Shimizu; Ryuzo Sakata
        CIRCULATION, Nov. 2014
      • Cell sheet transplantation to rat infarct heart using genomic integration-free human ips cells generated with episomal plasmid vectors: A strategy for tumor-free cardiac cell therapy
        Masumoto H; Ikuno T; Okita K; Marui A; Minakata K; Ikeda T; Sakata R; Yamashita J
        ISSCR 12th Annual Meeting, Jun. 2014, Peer-reviewed
      • PD-1-6 多能性幹細胞由来心臓組織シート移植 : 心筋組織再生を目指して(PD-1 パネルディスカッション(1)細胞・臓器移植における基礎的研究の最前線,第114回日本外科学会定期学術集会)
        松尾 武彦; 升本 英利; 丸井 晃; 南方 謙二; 池田 義; 山下 潤; 坂田 隆造
        日本外科学会雑誌, 05 Mar. 2014
      • SY-7-7 細胞シート技術を用いた多能性幹細胞による心筋再生研究 : 機能的再生から組織再生へ(SY シンポジウム,第113回日本外科学会定期学術集会)
        升本 英利; 南方 謙二; 丸井 晃; 池田 義; 清水 達也; 岡野 光夫; 山下 潤; 坂田 隆造
        日本外科学会雑誌, 05 Mar. 2013
      • Transplantation of Cell Sheets with Human iPS Cell-derived Cardiomyocytes and Vascular Cells for Infarcted Hearts: A Basic Study
        Hidetoshi Masumoto; Akira Marui; Tadashi Ikeda; Tatsuya Shimizu; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
        CIRCULATION, Nov. 2012
      • Transplantation of Cardiac Tissue Sheets Including Defined Cardiovascular Cell Populations Differentiated from Human-Induced Pluripotent Stem Cells Ameliorates Cardiac Dysfunction After Subacute Myocardial Infarction
        Hidetoshi Masumoto; Tadashi Ikeda; Tatsuya Shimizu; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
        CIRCULATION RESEARCH, Aug. 2012

      Awards

      • 09 Jun. 2012
        第12回比叡山ワークショップ最優秀賞(基礎研究部門)(京都大学医学部心臓血管外科同門会)
      • 03 Jun. 2011
        The Japanese Society of Inflammation and Regeneration, Poster Award, The 32nd Annual Meeting of Japanese Society of Inflammation and Regeneration
      • 14 Jun. 2012
        The Japanese Society for Regenerative Medicine, The most excellent prize, Basic research, The 4th Young Investigator’s Award, Japanese Society for Regenerative Medicine
      • 06 Jul. 2012
        The Japanese Society of Inflammation and Regeneration, The best poster award, The 33rd Annual Meeting of Japanese Society of Inflammation and Regeneration
      • 15 Feb. 2013
        Miyazaki Science Camp, Excellent prize, The 9th Miyazaki Science Camp
      • 12 Feb. 2019
        The Japanese Society for Cardiovascular Surgery, Most excellent prize, The 49th Annual Meeting of the Japanese Society for Cardiovascular Surgery

      External funds: others

      • Novartis Pharma AG, NIBR Global Scholars Program
        From 01 Jan. 2023, To 31 Dec. 2025
        Hidetoshi Masumoto
      • Study of a newly designed high-performance membrane oxygenator equipped with both local temperature control technology and non-fouling technology
        日本医療研究開発機構(AMED)医療分野研究成果展開事業先端計測分析技術・機器開発プログラム
        From 22 Jun. 2020, To 31 Mar. 2023
        織田 禎二
      • Study of immunological rejection related to iPS cell-derived artificial heart tissue transplantation for cardiac regenerative medicine
        日本医療研究開発機構(AMED)再生医療実現拠点ネットワークプログラム(技術開発個別課題)
        From 01 Oct. 2018, To 31 Mar. 2021
        湊谷 謙司
      • Development of a new surgical device for less-invasive transplantation of iPS cell-derived cardiac tissues
        京都大学産官学連携本部 GAPファンドプログラム
        From 01 Mar. 2019, To 29 Feb. 2020
        升本 英利
      • Research for identification of pathology-associated biomarkers of dilated cardiomyopathy model hamsters
        材料科学技術振興財団 共同研究
        From 01 Jan. 2019, To 31 Dec. 2019
        升本 英利
      • Development of technologies to establish functional tissue based on tissue engineering
        日本医療研究開発機構(AMED) 未来医療を実現する医療機器・システム研究開発事業
        From 01 Apr. 2018, To 31 Mar. 2019
        田畑 泰彦

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