Masumoto, Hidetoshi(KYOTO UNIVERSITY HOSPITAL) | Activity Database on Education and Research, Kyoto University

Masumoto, Hidetoshi

KYOTO UNIVERSITY HOSPITAL Program-Specific Professor

Last Updated :2026/05/15

Basic Information

Professional Memberships

日本心臓血管外科再生治療研究会・幹事

DDS再生治療研究会・世話人

The Asian Society for Cardiovascular and Thoracic Surgery

International Society of Stem Cell Research

European Society of Cardiology（Professional Member）

American Heart Association（Professional Member）

日本腫瘍循環器学会

日本DDS学会

日本炎症・再生医学会

日本再生医療学会（代議員）

日本心不全学会

日本循環器学会

日本外科学会

日本心臓血管外科学会（国際会員）

日本胸部外科学会（正会員）

Academic Degree

24 Sep. 2012
京都大学博士（医学）

Academic Resume (Graduate Schools)

京都大学, 大学院医学研究科博士課程医学専攻, 修了

京都大学, 大学院医学研究科博士課程医学専攻, 研究指導認定退学

Academic Resume (Undergraduate School/Majors)

京都大学, 医学部医学科, 卒業

Research History

From Apr. 2025, To Present
Kyoto University Hospital, Department of Cardiovascular Surgery, Project-Specific Professor

From Jul. 2023, To Mar. 2025
京都大学医学部附属病院, 心臓血管外科, 特定准教授

From Apr. 2018, To Mar. 2025
理化学研究所生命機能科学研究センター（組織改組に伴う名称変更）, 臨床橋渡しプログラム・升本研究室, 研究リーダー

From Oct. 2017, To Mar. 2023
京都大学医学部附属病院, 心臓血管外科, 特定助教

From Oct. 2017, To Mar. 2018
理化学研究所多細胞システム形成研究センター, 臨床橋渡しプログラム・升本研究室, 研究リーダー

From Oct. 2016, To Sep. 2017
京都大学医学部附属病院, 心臓血管外科, 助教

From Sep. 2015, To Sep. 2016
Kyoto University, iPS細胞研究所（CiRA）, 特定研究員（特命助教）

From Sep. 2013, To Aug. 2015
米国Louisville大学, Cardiovascular Innovation Institute, 博士研究員

From May 2012, To Aug. 2013
京都大学医学部附属病院, 心臓血管外科, 特定病院助教

From Nov. 2002, To Apr. 2008
静岡市立静岡病院, 心臓血管外科, 医員

From Mar. 2000, To Oct. 2002
国家公務員共済組合連合会熊本中央病院, 心臓血管外科, 医員

From May 1999, To Feb. 2000
Kyoto University Hospital, Department of Cardiovascular Surgery, 研修医

Profile

Profile
医学博士。再生医療認定医・循環器専門医。1999年京都大学医学部卒。熊本中央病院および静岡市立静岡病院心臓血管外科医員、米国Louisville大学博士研究員、京都大学iPS細胞研究所特命助教などを経て、2023年より京都大学医学部付属病院心臓血管外科特定准教授、2025年4月より現職。また2017年10月から2025年3月まで理化学研究所生命機能科学研究センター臨床橋渡しプログラム研究リーダーとして研究室を主宰（2025年4月～理研客員主管研究員）。2023年よりNovartis Institute for BioMedical Researchからの国際大型グラント NIBR Global Scholars Programを研究代表者として受領（日本初）。iPS細胞から作製した心臓オルガノイドの構造および機能的成熟化に関する研究を軸に、重症心臓病に対する新たな再生医療の開発、あるいは心臓病の再現による創薬研究に取り組んでいる。

Language of Instruction

Japanese

English

Last Updated :2026/05/15

Research

Research Topics, Overview of the research

Research Topics
Regenerative medicine in cardiovascular surgery
Overview of the research
Generation of human iPS cell-derived 3-dimensional cardiac tissue and the clinical application

Research Interests

Tissue engineering

Stem cell biology

Clinical translational research

Cardiology

Cardiovascular surgery

Regenerative medicine

Research Areas

Life sciences, Cardiovascular surgery

Papers

High and intermittent hydrostatic pressure promotes maturation of engineered cardiac tissues derived from human pluripotent stem cells
Maihemuti W.; Murata K.; Jimba T.; Iida J.; Hakamada K.; Sakaguchi A.; Abulaiti M.; Saito Y.; González-Teshima LY; Takatori S.; Kenmotsu T.; Yoshikawa K.; Minatoya K.; Nomura S.; Kimura W.; Masumoto H.
Stem Cell Reports, Jun. 2026, Peer-reviewed, Last author, Corresponding author

A Heart-on-a-Chip Microdevice with Aligned Fibers for Cardiotoxicity Assessment
Kozue Murata; Mosha Abulaiti; Rio Okama; Kensuke Kato; Yo Tanaka; Hidetoshi Masumoto
bioRxiv (preprint, under review), 04 May 2026, Peer-reviewed, Last author, Corresponding author

Self-Organized Vascularized Cardiac Microtissues Derived from Human iPS Cells Promote Myocardial Repair through Functional Host–Graft Vascular Integration
Keisuke Hakamada; Kozue Murata; Wusiman Maihemuti; Kenji Minatoya; Hidetoshi Masumoto
bioRxiv (preprint, in revision), 09 Feb. 2026, Peer-reviewed, Last author, Corresponding author

Human platelet lysate drives clinically compliant generation of vascular mural cells from human pluripotent stem cells
Laura Yuriko González-Teshima; Wusiman Maihemuti; Kozue Murata; Hidetoshi Masumoto
bioRxiv (preprint, under review), 06 Feb. 2026, Peer-reviewed, Last author, Corresponding author

Hepatic vein-derived factors may affect pulmonary arteriovenous malformations after single ventricle palliation by modulating vascular cell behavior.
Laura Yuriko González-Teshima; Keisuke Hakamada; Kozue Murata; Reiko Nakagawa; Shiro Baba; Yujiro Ide; Maiko Okamura; Akio Ikai; Tadashi Ikeda; Kenji Minatoya; Masaya Hagiwara; Masaya Ikegawa; Hidetoshi Masumoto
Scientific reports, 24 Nov. 2025, Peer-reviewed, Last author, Corresponding author

Recellularization of decellularized vascular grafts via aligned seeding of endothelial cells derived from human iPS cells.
Mako Kobayashi; Kozue Murata; Masaya Yamamoto; Yoshihide Hashimoto; Tsuyoshi Kimura; Hidetoshi Masumoto; Akio Kishida
Scientific reports, 03 Sep. 2025, Peer-reviewed
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Benzyl isothiocyanate induces heart regeneration.
Akane Sakaguchi; Miwa Kawasaki; Yuichi Saito; Kozue Murata; Hidetoshi Masumoto; Wataru Kimura
iScience, 18 Jul. 2025, Peer-reviewed

Production of bioactive cytokines using plant expression system for cardiovascular cell differentiation from human pluripotent stem cells.
Kozue Murata; Kanae Takamura; Risa Watanabe; Akitomo Nagashima; Miho Miyauchi; Yoshiteru Miyauchi; Hidetoshi Masumoto
Stem cell research & therapy, 25 Jun. 2025, Peer-reviewed, Last author, Corresponding author
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Transplantation of vascularized cardiac microtissue from human induced pluripotent stem cells improves impaired electrical conduction in a porcine myocardial injury model.
Yuki Kuroda; Jun Iida; Kozue Murata; Yuki Hori; Jumpei Kobiki; Kenji Minatoya; Hidetoshi Masumoto
JTCVS open, Jun. 2025, Peer-reviewed, Last author, Corresponding author
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Retention of locally injected human iPS cell-derived cardiomyocytes into the myocardium using hydrolyzed gelatin.
Jun Iida; Kazuki Kotani; Kozue Murata; Keisuke Hakamada; Wusiman Maihemuti; Yoshinobu Mandai; Yosuke Hiraoka; Kenji Minatoya; Hidetoshi Masumoto
Scientific reports, 07 Feb. 2025, Peer-reviewed, Last author, Corresponding author
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Surgical repair of coronary arteriovenous fistula: A simple and useful approach to identify the fistulous communication
Kim Hyun Il; Takaaki Koshiji; Minoru Okamoto; Yoshio Arai; Hidetoshi Masumoto
European Journal of Cardio-thoracic Surgery, 2001

Simultaneous electro-dynamic stimulation accelerates maturation of engineered cardiac tissues generated by human iPS cells
Wusiman Maihemuti; Kozue Murata; Mosha Abulaiti; Kenji Minatoya; Hidetoshi Masumoto
Biochemical and Biophysical Research Communications, Nov. 2024, Peer-reviewed, Last author, Corresponding author
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Progress in the generation of multiple lineage human-iPSC-derived 3D-engineered cardiac tissues for cardiac repair
Fei Ye; Shuji Setozaki; William J. Kowalski; Marc Dwenger; Fangping Yuan; Joseph P. Tinney; Takeichiro Nakane; Hidetoshi Masumoto; Bradley B. Keller
Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension, 01 Jan. 2020

miR-124-3p downregulates EGR1 to suppress ischemia-hypoxia reperfusion injury in human iPS cell-derived cardiomyocytes.
Qiaoke Yang; Kozue Murata; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto
Scientific reports, 27 Jun. 2024, Peer-reviewed, Last author, Corresponding author

ヒトiPS細胞由来の薬剤誘発性Torsade de Pointes再現心臓組織モデル
川東正英; 升本英利; 森永学; 芦原貴司; 山下潤
日本内分泌学会雑誌, Dec. 2018

Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model.
Kozue Murata; Akiko Makino; Keizo Tomonaga; Hidetoshi Masumoto
iScience, 19 Jan. 2024, Peer-reviewed, Last author, Corresponding author
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Therapeutic potential of human induced pluripotent stem cell-derived cardiac tissue in an ischemic model with unloaded condition mimicking left ventricular assist device.
Daisuke Heima; Masafumi Takeda; Yasuhiko Tabata; Kenji Minatoya; Jun K Yamashita; Hidetoshi Masumoto
The Journal of thoracic and cardiovascular surgery, 21 Nov. 2023, Peer-reviewed, Last author, Corresponding author

拡張型心筋症モデルハムスターの網羅的代謝イメージング解析
岡邑舞子; 山口真一; 山本卓志; 袴田圭祐; 新谷祈; 辻崇; 植田初江; 雨宮妃; 湊谷謙司; 升本英利; 池川雅哉
JSBMS Letters, Aug. 2022

Quiescence-inducing neurons-induced hypometabolism ameliorates acute kidney injury in a mouse model mimicking cardiovascular surgery requiring circulatory arrest.
Shoichi Kyo; Kozue Murata; Masahide Kawatou; Kenji Minatoya; Genshiro A Sunagawa; Hidetoshi Masumoto
JTCVS open, Dec. 2022, Peer-reviewed, Last author, Corresponding author
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A novel approach for the endothelialization of xenogeneic decellularized vascular tissues by human cells utilizing surface modification and dynamic culture
Wen-Jin Ho; Mako Kobayashi; Kozue Murata; Yoshihide Hashimoto; Kenji Izumi; Tsuyoshi Kimura; Hideo Kanemitsu; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto
Scientific Reports, 24 Dec. 2022, Peer-reviewed, Last author, Corresponding author
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拡張型心筋症モデルハムスターの網羅的代謝イメージング解析
岡邑舞子; 山口真一; 山本卓志; 袴田圭祐; 新谷祈; 辻崇; 植田初江; 雨宮妃; 湊谷謙司; 升本英利; 池川雅哉
JSBMS Letters, Aug. 2022

Pioglitazone-incorporated microspheres targeting macrophage polarization alleviates cardiac dysfunction after myocardial infarction.
Yasushi Konegawa; Toshie Kuwahara; Jun-Ichiro Jo; Kozue Murata; Takahide Takeda; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto; Yasuhiko Tabata
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 10 Aug. 2022, Peer-reviewed, Corresponding author

Systems for the Functional Evaluation of Human Heart Tissues Derived from Pluripotent Stem Cells.
Kozue Murata; Hidetoshi Masumoto
Stem cells (Dayton, Ohio), 22 Jun. 2022, Peer-reviewed, Last author, Corresponding author
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Evaluations for surrounding tissue incorporation after implantation of synthetic vascular prostheses in animal models.
Yasue Fujiwara; Shingo Hirao; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto
Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, Mar. 2022, Peer-reviewed, Last author, Corresponding author

Therapeutic potential of clinical-grade human induced pluripotent stem cell-derived cardiac tissues
Hiroaki Osada; Masahide Kawatou; Daiki Fujita; Yasuhiko Tabata; Kenji Minatoya; Jun K. Yamashita; Hidetoshi Masumoto
JTCVS Open, Dec. 2021, Peer-reviewed, Last author, Corresponding author
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In vivo recellularization of xenogeneic vascular grafts decellularized with high hydrostatic pressure method in a porcine carotid arterial interpose model
Shunji Kurokawa; Yoshihide Hashimoto; Seiichi Funamoto; Kozue Murata; Akitatsu Yamashita; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Akio Kishida; Hidetoshi Masumoto
PLOS ONE, 22 Jul. 2021, Peer-reviewed, Last author, Corresponding author

Generation of Cylindrical Engineered Cardiac Tissues from Human iPS Cell-Derived Cardiovascular Cell Lineages.
Hidetoshi Masumoto
Methods in molecular biology (Clifton, N.J.), 2021, Peer-reviewed, Lead author, Corresponding author

Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
Marc Dwenger; William J. Kowalski; Hidetoshi Masumoto; Takeichiro Nakane; Bradley B. Keller
Methods in Molecular Biology, 2021, Peer-reviewed

Strategies for immune regulation in iPS cell-based cardiac regenerative medicine
Kozue Murata; Masaya Ikegawa; Kenji Minatoya; Hidetoshi Masumoto
Inflammation and Regeneration, Dec. 2020, Peer-reviewed, Last author, Corresponding author

Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
Mosha Abulaiti; Yaxiaer Yalikun; Kozue Murata; Asako Sato; Mustafa M. Sami; Yuko Sasaki; Yasue Fujiwara; Kenji Minatoya; Yuji Shiba; Yo Tanaka; Hidetoshi Masumoto
Scientific Reports, Dec. 2020, Peer-reviewed, Last author, Corresponding author

Novel device prototyping for endoscopic cell sheet transplantation using a three-dimensional printed simulator
Hiroaki Osada; Wen-Jin Ho; Hideki Yamashita; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto
Regenerative Therapy, Dec. 2020, Peer-reviewed, Last author, Corresponding author
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The N-terminal lectin-like domain of thrombomodulin reduces acute lung injury without anticoagulant effects in a rat cardiopulmonary bypass model
Tatsuya Itonaga; Shingo Hirao; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Hidetoshi Masumoto
General Thoracic and Cardiovascular Surgery, Aug. 2020, Peer-reviewed, Last author, Corresponding author

Management of retrosternal adhesion after median sternotomy by controlling degradation speed of a dextran and ε-poly (l-lysine)-based biocompatible glue
Fumie Takai; Takahide Takeda; Kazuhiro Yamazaki; Tadashi Ikeda; Suong-Hyu Hyon; Kenji Minatoya; Hidetoshi Masumoto
General Thoracic and Cardiovascular Surgery, Aug. 2020, Peer-reviewed, Last author, Corresponding author

Accuracy of spiked cell counting methods for designing a pre-clinical tumorigenicity study model.
Hiroaki Osada; Masahide Kawatou; Masafumi Takeda; Jun-Ichiro Jo; Takashi Murakami; Yasuhiko Tabata; Kenji Minatoya; Jun K Yamashita; Hidetoshi Masumoto
Heliyon, Jul. 2020, Peer-reviewed, Last author, Corresponding author

Preparation of Mesh-Shaped Engineered Cardiac Tissues Derived from Human iPS Cells for In Vivo Myocardial Repair
Takeichiro Nakane; Mosha Abulaiti; Yuko Sasaki; William J. Kowalski; Bradley B. Keller; Hidetoshi Masumoto
Journal of Visualized Experiments, 09 Jun. 2020, Peer-reviewed, Last author, Corresponding author

A Rabbit Venous Interposition Model Mimicking Revascularization Surgery using Vein Grafts to Assess Intimal Hyperplasia under Arterial Blood Pressure
Hiroomi Nishio; Kenji Minatoya; Hidetoshi Masumoto
Journal of Visualized Experiments, 15 May 2020, Peer-reviewed, Last author, Corresponding author

Basic fibroblast growth factor attenuates left-ventricular remodeling following surgical ventricular restoration in a rat ischemic cardiomyopathy model.
Atsushi Nagasawa; Hidetoshi Masumoto; Shigeki Yanagi; Naoki Kanemitsu; Tadashi Ikeda; Yasuhiko Tabata; Kenji Minatoya
General thoracic and cardiovascular surgery, Apr. 2020, Peer-reviewed

Chronic optical pacing conditioning of h-iPSC engineered cardiac tissues
Marc Dwenger; William J Kowalski; Fei Ye; Fangping Yuan; Joseph P Tinney; Shuji Setozaki; Takeichiro Nakane; Hidetoshi Masumoto; Peter Campbell; William Guido; Bradley B Keller
Journal of Tissue Engineering, Jan. 2019, Peer-reviewed

Development of a bioassay system to evaluate the pulsatile function of human heart tissue using a cellular micropump on-chip and a biomimetic human iPS cell-derived heart tissue sheet technology
Abulaiti Mosha; Kozue Murata; Yalikun Yaxiaer; Yo Tanaka; Hidetoshi Masumoto
Proceeding of Micro Total Analysis Systems 2018, Nov. 2018, Peer-reviewed, Last author, Corresponding author

Sustained release of basic fibroblast growth factor using gelatin hydrogel improved left ventricular function through the alteration of collagen subtype in a rat chronic myocardial infarction model.
Li Z; Masumoto H; Jo JI; Yamazaki K; Ikeda T; Tabata Y; Minatoya K
General thoracic and cardiovascular surgery, Nov. 2018, Peer-reviewed, Corresponding author

MicroRNA-145-loaded poly(lactic-co-glycolic acid) nanoparticles attenuate venous intimal hyperplasia in a rabbit model.
Nishio H; Masumoto H; Sakamoto K; Yamazaki K; Ikeda T; Minatoya K
The Journal of thoracic and cardiovascular surgery, Oct. 2018, Peer-reviewed, Corresponding author

Therapeutic angiogenesis by local sustained release of microRNA-126 using poly lactic-co-glycolic acid nanoparticles in murine hindlimb ischemia.
Tsumaru S; Masumoto H; Minakata K; Izuhara M; Yamazaki K; Ikeda T; Ono K; Sakata R; Minatoya K
Journal of vascular surgery, Oct. 2018, Peer-reviewed, Corresponding author

拡張型心筋症ハムスターモデルの病態解析と超高速イメージング質量分析法を用いたプロテオミック・バイオマーカー探索
新谷祈; 辻崇; 石田瑞希; 韮澤崇; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
JSBMS Letters, Aug. 2018

A therapeutic angiogenesis of sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel sheets in a canine chronic myocardial infarction model
Motoyuki Kumagai; Kenji Minakata; Hidetoshi Masumoto; Masaya Yamamoto; Atsushi Yonezawa; Takafumi Ikeda; Kyokun Uehara; Kazuhiro Yamazaki; Tadashi Ikeda; Kazuo Matsubara; Masayuki Yokode; Akira Shimizu; Yasuhiko Tabata; Ryuzo Sakata; Kenji Minatoya
Heart and Vessels, 14 May 2018, Peer-reviewed, Corresponding author

A recovery cardiopulmonary bypass model without transfusion or inotropic agents in rats
Shingo Hirao; Hidetoshi Masumoto; Tatsuya Itonaga; Kenji Minatoya
Journal of Visualized Experiments, 20 Mar. 2018, Peer-reviewed, Corresponding author

Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82
Masafumi Takeda; Yasuharu Kanki; Hidetoshi Masumoto; Shunsuke Funakoshi; Takeshi Hatani; Hiroyuki Fukushima; Akashi Izumi-Taguchi; Yusuke Matsui; Teppei Shimamura; Yoshinori Yoshida; Jun K. Yamashita
Cell Reports, 2018, Peer-reviewed
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Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts.
Ishigami M; Masumoto H; Ikuno T; Aoki T; Kawatou M; Minakata K; Ikeda T; Sakata R; Yamashita JK; Minatoya K
PloS one, 2018, Peer-reviewed, Corresponding author
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Human iPS cell-engineered three-dimensional cardiac tissues perfused by capillary networks between host and graft.
Masumoto H; Yamashita JK
Inflammation and regeneration, 2018, Peer-reviewed, Lead author, Corresponding author

Recombinant human soluble thrombomodulin prevents acute lung injury in a rat cardiopulmonary bypass model
Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Kazuhiro Yamazaki; Tadashi Ikeda; Kenji Minatoya; Ryuzo Sakata
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Dec. 2017, Peer-reviewed, Corresponding author

Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue
Masahide Kawatou; Hidetoshi Masumoto; Hiroyuki Fukushima; Gaku Morinaga; Ryuzo Sakata; Takashi Ashihara; Jun K. Yamashita
NATURE COMMUNICATIONS, Oct. 2017, Peer-reviewed
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Quantification of Cardiomyocyte Alignment from Three-Dimensional (3D) Confocal Microscopy of Engineered Tissue
William J. Kowalski; Fangping Yuan; Takeichiro Nakane; Hidetoshi Masumoto; Marc Dwenger; Fei Ye; Joseph P. Tinney; Bradley B. Keller
MICROSCOPY AND MICROANALYSIS, Aug. 2017, Peer-reviewed

Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model
Shuji Setozaki; Kenji Minakata; Hidetoshi Masumoto; Shingo Hirao; Kazuhiro Yamazaki; Koichiro Kuwahara; Tadashi Ikeda; Ryuzo Sakata
JOURNAL OF VASCULAR SURGERY, Jun. 2017, Peer-reviewed

Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017)
Takeshi Ikuno; Hidetoshi Masumoto; Kohei Yamamizu; Miki Yoshioka; Kenji Minakata; Tadashi Ikeda; Ryuzo Sakata; Jun K. Yamashita
PLOS ONE, Apr. 2017, Peer-reviewed

Impact of Cell Composition and Geometry on Human Induced Pluripotent Stem Cells-Derived Engineered Cardiac Tissue
Takeichiro Nakane; Hidetoshi Masumoto; Joseph P. Tinney; Fangping Yuan; William J. Kowalski; Fei Ye; Amanda J. LeBlanc; Ryuzo Sakata; Jun K. Yamashita; Bradley B. Keller
SCIENTIFIC REPORTS, Apr. 2017, Peer-reviewed
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Efficient and robust differentiation of endothelial cells from human induced pluripotent stem cells via lineage control with VEGF and cyclic AMP (vol 12, e0173271, 2017)
Takeshi Ikuno; Hidetoshi Masumoto; Kohei Yamamizu; Miki Yoshioka; Kenji Minakata; Tadashi Ikeda; Ryuzo Sakata; Jun K. Yamashita
PLOS ONE, Apr. 2017, Peer-reviewed

Fetal mesenchymal stem cells ameliorate acute lung injury in a rat cardiopulmonary bypass model
Tomofumi Taki; Hidetoshi Masumoto; Masaki Funamoto; Kenji Minakata; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2017, Peer-reviewed, Corresponding author

Untiring steps toward the maturation of human stem cell-engineered heart tissue
Hidetoshi Masumoto; Jun K. Yamashita
Annals of Translational Medicine, 01 Feb. 2017, Peer-reviewed, Lead author, Corresponding author

Therapeutic angiogenesis with growth factor using drug delivery system in cardiovascular medicine
Kenji Minakata; Hiroomi Nishio; Hidetoshi Masumoto; Ryuzo Sakata
Drug Delivery System, 2017, Peer-reviewed

Human iPS Cell-Derived Cardiac Tissue Sheets: a Platform for Cardiac Regeneration
Hidetoshi Masumoto; Jun K. Yamashita
Current Treatment Options in Cardiovascular Medicine, 01 Nov. 2016, Peer-reviewed, Lead author, Corresponding author

The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages
Hidetoshi Masumoto; Takeichiro Nakane; Joseph P. Tinney; Fangping Yuan; Fei Ye; William J. Kowalski; Kenji Minakata; Ryuzo Sakata; Jun K. Yamashita; Bradley B. Keller
SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed, Lead author
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Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass
Masaki Funamoto; Hidetoshi Masumoto; Koji Takaori; Tomofumi Taki; Shuji Setozaki; Kazuhiro Yamazaki; Kenji Minakata; Tadashi Ikeda; Suong-Hyu Hyon; Ryuzo Sakata
ANNALS OF THORACIC SURGERY, Apr. 2016, Peer-reviewed

Exploiting human iPS cell-derived cardiovascular cell populations toward cardiac regenerative therapy.
Masumoto H; Yamashita JK
Stem Cell Transl Investig, 2016, Peer-reviewed, Lead author, Corresponding author

Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes
Keller BB; Ye F; Yuan F; Trada H; Tinney JP; Walsh KM; Masumoto H; Nakanishi T; Markwald RR; Baldwin HS; Keller BB; Srivastava D; Yamagishi H
2016, Peer-reviewed

ブタ心筋梗塞モデルを用いたiPS細胞由来心臓組織シート移植による不整脈評価実験
幾野毅; 青木隆之; 升本英利; 小原浩; 中村裕二; 中瀬古寛子; 安東賢太郎; 川東正英; 石上雅之助; 南方謙二; 池田義; 杉山篤; 山下潤; 坂田隆造
日本バイオマテリアル学会大会予稿集, Nov. 2015

Efficient long-term survival of cell grafts after myocardial infarction with thick viable cardiac tissue entirely from pluripotent stem cells
Takehiko Matsuo; Hidetoshi Masumoto; Shuhei Tajima; Takeshi Ikuno; Shiori Katayama; Kenji Minakata; Tadashi Ikeda; Kohei Yamamizu; Yasuhiko Tabata; Ryuzo Sakata; Jun K. Yamashita
SCIENTIFIC REPORTS, Nov. 2015, Peer-reviewed
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Human iPS cell-engineered cardiac tissue sheets with cardiomyocytes and vascular cells for cardiac regeneration
Hidetoshi Masumoto; Takeshi Ikuno; Masafumi Takeda; Hiroyuki Fukushima; Akira Marui; Shiori Katayama; Tatsuya Shimizu; Tadashi Ikeda; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
SCIENTIFIC REPORTS, Oct. 2014, Peer-reviewed, Lead author

Effect of microRNA-145 to prevent vein graft disease in rabbits by regulation of smooth muscle cell phenotype
Motoaki Ohnaka; Akira Marui; Kenichi Yamahara; Kenji Minakata; Kazuhiro Yamazaki; Motoyuki Kumagai; Hidetoshi Masumoto; Shiro Tanaka; Tadashi Ikeda; Ryuzo Sakata
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Aug. 2014, Peer-reviewed

Effects of hepatocyte growth factor in myocarditis rats induced by immunization with porcine cardiac myosin
Jota Nakano; Akira Marui; Hiroyuki Muranaka; Hidetoshi Masumoto; Hisashi Noma; Yasuhiko Tabata; Akio Ido; Hirohito Tsubouchi; Tadashi Ikeda; Ryuzo Sakata
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, Mar. 2014, Peer-reviewed

Efficiently Piled-Up Cardiac Tissue-Like Sheets With Pluripotent Stem Cell-Derived Cells Robustly Promotes Cell Engraftment and Ameliorates Cardiac Dysfunction After Myocardial Infarction
Takehiko Matsuo; Hidetoshi Masumoto; Shuhei Tajima; Akira Marui; Kenji Minakata; Tadashi Ikeda; Yasuhiko Tabata; Ryuzo Sakata; Jun K. Yamashita
CIRCULATION, Nov. 2013, Peer-reviewed

Prevention of retrosternal adhesion by novel biocompatible glue derived from food additives
Tetsuya Kamitani; Hidetoshi Masumoto; Hirokazu Kotani; Tadashi Ikeda; Suong-Hyu Hyon; Ryuzo Sakata
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, Nov. 2013, Peer-reviewed

自家静脈グラフトにおけるmicroRNA-145を用いた血管平滑筋制御
大仲玄明; 丸井晃; 山原研一; 南方謙二; 山崎和裕; 熊谷基之; 升本英利; 池田義; 坂田隆造
日本血管外科学会雑誌, Apr. 2013

Strategies in cell therapy for cardiac regeneration
Masumoto Hidetoshi; Yamashita Jun K.
Inflammation and Regeneration, 2013, Peer-reviewed, Lead author

Cardiovascular surgery for realization of regenerative medicine
Hidetoshi Masumoto; Ryuzo Sakata
General Thoracic and Cardiovascular Surgery, Nov. 2012, Peer-reviewed, Lead author
Access this paper :

Pluripotent Stem Cell-Engineered Cell Sheets Reassembled with Defined Cardiovascular Populations Ameliorate Reduction in Infarct Heart Function Through Cardiomyocyte-Mediated Neovascularization
Hidetoshi Masumoto; Takehiko Matsuo; Kohei Yamamizu; Hideki Uosaki; Genta Narazaki; Shiori Katayama; Akira Marui; Tatsuya Shimizu; Tadashi Ikeda; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
STEM CELLS, Jun. 2012, Peer-reviewed, Lead author

Pluripotent stem cell-derived defined cardiac tissue sheets demonstrate cardiac repair through cardiomyocyte-mediated neovascularization
升本英利; 山下潤
Vol.11/No.4 : p56－62, 2012．日本再生医療学会, 2012, Peer-reviewed, Lead author

A Case Report of Valve Dysfunction Associated with Abrasion of the Delrin Disk Used in Early Bjork-Shiley Mitral Valves Requiring Resurgery
Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Nakai Masanao; Shoji Fujita; Yujiro Miura; Tatsuya Itonaga; Hiroki Ito
ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, Apr. 2009, Peer-reviewed, Lead author, Corresponding author

Airway stenosis associated with a mycotic pseudoaneurysm of the common carotid artery
Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Masanao Nakai; Shoji Fujita; Yujiro Miura
General Thoracic and Cardiovascular Surgery, May 2008, Peer-reviewed, Lead author, Corresponding author

A case of heparin-induced thrombocytopenia with repeated episodes of acute lower extremity arterial thromboembolism during a short time
Hidetoshi Masumoto; Mitsuomi Shimamoto; Fumio Yamazaki; Masanao Nakai; Shoji Fujita; Tatsuya Itonaga; Ryota Nomura
Annals of Thoracic and Cardiovascular Surgery, Oct. 2007, Peer-reviewed, Lead author, Corresponding author

Surgical treatment of thoracic aortic aneurysm in patients with concomitant coronary artery disease
Masanao Nakai; Mitsuomi Shimamoto; Fumio Yamasaki; Shoji Fujita; Hidetoshi Masumoto; Tetsu Yamada; Daisuke Nakajima; Masatsugu Hamaji
Japanese Journal of Thoracic and Cardiovascular Surgery, 2005, Peer-reviewed

Two successful cases of coronary artery bypass grafting followed by transluminal carotid angioplasty with stenting
T. Matsuo; T. Nishina; H. Masumoto; K. Tanbara; K. Ueyama; Y. Fujioka; M. Hanyu; T. Ikeda; K. Nishimura; M. Komeda
Kyobu geka. The Japanese journal of thoracic surgery, 2001, Peer-reviewed

Misc.

開存バイパスグラフトを有する再開心術症例の検討
岡本実; 腰地孝昭; 新井善雄; 升本英利; 幾野毅
Circulation Journal, 20 Apr. 2003

特発性血小板減少性紫斑病合併患者に対するCABG2治験例について
岡本実; 腰地孝昭; 新井善雄; 金賢一; 升本英利
Circulation Journal, 20 Apr. 2002

下大静脈穿破を伴った腹部大動脈破裂の2例
幾野毅; 腰地孝昭; 岡本実; 新井善雄; 塚下将樹; 升本英利
日本血管外科学会雑誌, Jun. 2003

超高齢者(80歳以上)開心術後の遠隔期QOL
新井善雄; 腰地孝昭; 岡本実; 升本英利; 幾野毅; 坂田隆造
日本心臓血管外科学会雑誌, Apr. 2003

橈骨動脈グラフトの術前後での径変化についての検討
升本英利; 腰地孝昭; 岡本実; 新井善雄; 幾野毅
日本心臓血管外科学会雑誌, Apr. 2003

上行弓部下行重複大動脈瘤一期的手術例
岡本実; 腰地孝昭; 新井善雄; 升本英利
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2003

成人ASDの傾向と治療成績
新井善雄; 腰地孝昭; 岡本実; 升本英利; 坂田隆造
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2003

感染性ペースメーカーリードに対する開心術下摘出の2治験例
升本英利; 腰地孝昭; 岡本実; 新井善雄; 金賢一
Circulation Journal, 20 Apr. 2002

橈骨動脈グラフト使用CABGの初期成績
升本英利; 腰地孝昭; 岡本実; 新井善雄; 金賢一
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Mar. 2002

左冠動脈主幹部を含む冠動脈瘤の1治験例
新井善雄; 腰地孝昭; 岡本実; 金賢一; 升本英利; 斉藤太郎
Japanese Circulation Journal, 20 Oct. 2001

弓部分枝再建を要した胸部大動脈疾患に対する外科治療成績についての検討
金賢一; 坂田隆造; 腰地孝昭; 岡本実; 新井善雄; 升本英利
The Japanese Journal of THORACIC AND CARDIOVASCULAR SURGERY, Sep. 2001

冠血行再建を伴う弁手術症例の中期遠隔期成績の検討
新井善雄; 坂田隆造; 腰地孝昭; 岡本実; 金賢一; 升本英利
日本心臓血管外科学会雑誌, Jan. 2001

体外循環にModificationを要した冠状動脈バイパス術の検討
腰地孝昭; 坂田隆造; 岡本実; 新井善雄; 金賢一; 升本英利
日本冠疾患学会雑誌, Nov. 2000

開存バイパスグラフトを有した弁膜症再手術症例の検討
腰地孝昭; 岡本実; 新井善雄; 升本英利; 幾野毅; 坂田隆造
日本心臓血管外科学会雑誌, Apr. 2003

イメージング質量分析法を用いた拡張型心筋症ハムスターモデルのin depth組織プロテオーム解析
新谷祈; 辻崇; 石田瑞希; 韮澤崇; 角田伸人; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
JSBMS Letters, 2019

J2N-kハムスター拡張型心筋症モデルにおけるバイオマーカー探索および病態解明に向けたMALDIイメージング質量分析およびショットガンプロテオミクスの併用
辻崇; 新谷祈; 石田瑞樹; 韮澤崇; 梶田遼; BRUNEVAL Patrick; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
日本胸部外科学会定期学術集会(Web), 2020

Recombinant human soluble thrombomodulin prevents acute lung injury induced by cardiopulmonary bypass in rats
S. Hirao; K. Minakata; H. Masumoto; M. Funamoto; S. Setozaki; K. Yamazaki; T. Ikeda; R. Sakata
EUROPEAN HEART JOURNAL, Aug. 2016

Therapeutic angiogenesis by local sustained release of microRNA-126 in murine hindlimb ischemia
S. Tsumaru; K. Minakata; H. Masumoto; K. Ono; M. Izuhara; K. Yamazaki; T. Ikeda; R. Sakata
EUROPEAN HEART JOURNAL, Aug. 2016

Cardiac tissue sheet including human iPS cell-derived cardiomyocytes and vascular cells restores impaired left ventricular systolic function of infarcted porcine hearts: a preclinical study
H. Masumoto; M. Ishigami; T. Aoki; F. Takai; T. Ikuno; M. Kawatoh; K. Minakata; T. Ikeda; R. Sakata; J. Yamashita
EUROPEAN HEART JOURNAL, Aug. 2015

Scalable and highly efficient endothelial cell differentiation methods from human induced pluripotent stem cells based on monolayer and serum-free culture
T. Ikuno; H. Masumoto; A. Marui; K. Minakata; T. Ikeda; R. Sakata; J. K. Yamashita
EUROPEAN HEART JOURNAL, Sep. 2014

Efficient endothelial cell differentiation protocol from human induced pluripotent stem cells based on monolayer and serum-free culture for realization of vascular regenerative medicine
T. Ikuno; H. Masumoto; A. Marui; T. Ikeda; R. Sakata; J. K. Yamashita
EUROPEAN HEART JOURNAL, Aug. 2013

Transplantation of cardiac tissue sheets including human induced pluripotent stem cell-derived defined cardiovascular cell populations ameliorates cardiac function after myocardial infarction
H. Masumoto; T. Ikeda; T. Shimizu; T. Okano; R. Sakata; J. K. Yamashita
EUROPEAN HEART JOURNAL, Aug. 2012

Central role of cardiomyocytes in cell therapy: transplantation of cardiac tissue sheets with defined cell populations from pluripotent stem cells
H. Masumoto; T. Shimizu; T. Ikeda; T. Okano; R. Sakata; J. K. Yamashita
EUROPEAN HEART JOURNAL, Aug. 2011

Differentiation toward cardiovascular cell populations from human iPS cells
升本英利; 山下潤
医学のあゆみ, 14 Mar. 2015

Dissecting pathogenesis of dilated cardiomyopathy (DCM) on J2N-k Hamster model using MALDI-Imaging Mass Spectrometry in combination with shotgun proteomics
新谷祈; 辻崇; 韮澤崇; 梶田遼; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
JSBMS Letters, 2020

拡張型心筋症モデルJ2-kハムスターおける病態解析:超高速イメージング質量分析法を用いた心筋組織プロテオームの視点から
辻崇; 新谷祈; 石田瑞希; 韮澤崇; 植田初江; 池川雅哉; 升本英利; 湊谷謙司
日本胸部外科学会定期学術集会(Web), 2019

拡張型心筋症ハムスターモデルの病態解析と超高速イメージング質量分析法を用いたプロテオミック・バイオマーカー探索
新谷祈; 辻崇; 石田瑞希; 韮澤崇; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
JSBMS Letters, 2018

拡張型心筋症モデルJ2-kハムスターの発症機序に関する一考察:イメージング質量分析法を用いた心筋組織プロテオームの視点から
辻崇; 新谷祈; 石田瑞希; 韮澤崇; 植田初江; 升本英利; 湊谷謙司; 池川雅哉
日本血管生物医学会学術集会プログラム・抄録集, 2018

Angiogenic Effects of Local Sustained Release of MicroRNA-126 in Murine Hindlimb Ischemia
Shinichi Tsumaru; Kenji Minakata; Hidetoshi Masumoto; Koh Ono; Masayasu Izuhara; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
CIRCULATION, Nov. 2016

Recombinant Human Soluble Thrombomodulin Prevents Acute Lung Injury in a Rat Cardiopulmonary Bypass Model
Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Shuji Setozaki; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
CIRCULATION, Nov. 2016

Recombinant Human Soluble Thrombomodulin Prevents Acute Lung Injury in a Rat Cardiopulmonary Bypass Model
Shingo Hirao; Kenji Minakata; Hidetoshi Masumoto; Shuji Setozaki; Kazuhiro Yamazaki; Tadashi Ikeda; Ryuzo Sakata
CIRCULATION, Nov. 2016

Human iPS cell-engineered 3D-cardiovascular tissue by stacking sheets with gelatin hydrogel microspheres for cardiac regenerative medicine
K. Yamamizu; T. Ikuno; H. Takakubo; H. Masumoto; K. Minakata; Y. Tabata; J. K. Yamashita
EUROPEAN HEART JOURNAL, Aug. 2016

A Novel Method to Therapeutic Angiogenesis by Sustained Release of Basic Fibroblast Growth Factor Using Biodegradable Gelatin Hydrogel Sheet in a Canine Chronic Myocardial Infarction Model
Motoyuki Kumagai; Akira Marui; Yasuhiko Tabata; Eiji Yoshikawa; Masaya Yamamoto; Atsushi Yonezawa; Shiro Tanaka; Takafumi Ikeda; Hidetoshi Masumoto; Tomohiro Nakata; Hisashi Sakaguchi; Kenji Minakata; Kazuhiro Yamazaki; Tadasi Ikeda; Masayuki Yokode; Akira Shimizu; Ryuzo Sakata
CIRCULATION, Nov. 2014

Cell sheet transplantation to rat infarct heart using genomic integration-free human ips cells generated with episomal plasmid vectors: A strategy for tumor-free cardiac cell therapy
Masumoto H; Ikuno T; Okita K; Marui A; Minakata K; Ikeda T; Sakata R; Yamashita J
ISSCR 12th Annual Meeting, Jun. 2014, Peer-reviewed

PD-1-6 多能性幹細胞由来心臓組織シート移植 : 心筋組織再生を目指して(PD-1 パネルディスカッション(1)細胞・臓器移植における基礎的研究の最前線,第114回日本外科学会定期学術集会)
松尾武彦; 升本英利; 丸井晃; 南方謙二; 池田義; 山下潤; 坂田隆造
日本外科学会雑誌, 05 Mar. 2014

SY-7-7 細胞シート技術を用いた多能性幹細胞による心筋再生研究 : 機能的再生から組織再生へ(SY シンポジウム,第113回日本外科学会定期学術集会)
升本英利; 南方謙二; 丸井晃; 池田義; 清水達也; 岡野光夫; 山下潤; 坂田隆造
日本外科学会雑誌, 05 Mar. 2013

Transplantation of Cell Sheets with Human iPS Cell-derived Cardiomyocytes and Vascular Cells for Infarcted Hearts: A Basic Study
Hidetoshi Masumoto; Akira Marui; Tadashi Ikeda; Tatsuya Shimizu; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
CIRCULATION, Nov. 2012

Transplantation of Cardiac Tissue Sheets Including Defined Cardiovascular Cell Populations Differentiated from Human-Induced Pluripotent Stem Cells Ameliorates Cardiac Dysfunction After Subacute Myocardial Infarction
Hidetoshi Masumoto; Tadashi Ikeda; Tatsuya Shimizu; Teruo Okano; Ryuzo Sakata; Jun K. Yamashita
CIRCULATION RESEARCH, Aug. 2012

Presentations

ヒトiPS細胞由来心臓オルガノイドによる心疾患研究と再生医療への展開
升本英利
2025年度都医学研セミナー（東京都医学総合研究所）, Mar. 2026, Invited

心臓再生医療の最前線
升本英利
第51回日本脳卒中学会学術集会教育講演2, Mar. 2026, Invited

iPS細胞由来心臓オルガノイドの臨床応用に向けた品質評価の考え方と課題
升本英利
第25回日本再生医療学会総会シンポジウム40「オルガノイド型ヒト細胞加工製品の品質評価に関するガイドラインの策定に向けて」, Mar. 2026, Invited

心臓移植を補完する再生医療としての心臓オルガノイド移植：その可能性と限界
升本英利
第25回日本再生医療学会総会シンポジウム19「臓器移植と再生医療のクロストーク」, Mar. 2026, Invited

ヒトiPS細胞由来心臓オルガノイドに基づく新たな心臓再生医療の開発
升本英利
Seeds-Hubフォーラム「研究予算の稼ぎ方」, Mar. 2025, Invited

細胞シート技術に基づく心臓オルガノイドによる次世代循環器医療の展望
升本英利
第4回細胞シート工学イノベーションフォーラム, Nov. 2025, Invited

心臓オルガノイドの成熟化と再生医療応用への展望
升本英利
2025年度日本心脈管作動物質学会若手研究者交流シンポジウム, Sep. 2025, Invited

ティッシュエンジニアリング技術に基づく心臓オルガノイドの構築と医療応用
升本英利
第46回日本炎症・再生医学会シンポジウム6 再生誘導医療を具現化するティッシュエンジニアリング技術, Jul. 2025, Invited

iPS細胞による次世代の循環器病治療の実現をめざして
升本英利
LINK-J×京都大学共催セミナー vol. 4 京都大学の研究と成果の活用～「in vitro HUMANOID」を基盤にした先端医療研究とその応用～, Apr. 2025, Invited

The Creation of Heart Organoids Targeted for Medical Applications
Masumoto H.
2025 RIKEN BDR-CuSTOM Joint Organoid Symposium, Mar. 2025, Invited

心臓オルガノイドの成熟化と臨床応用への展望
升本英利
第24回日本再生医療学会総会シンポジウム17 iPS心筋の臨床応用への挑戦, Mar. 2025, Invited

iPS細胞が拓く未来の心筋再生治療
升本英利
第55回日本心臓血管外科学会学術総会パネルディスカッション2 日本が誇る心臓血管外科領域の研究の最前線, Feb. 2025, Invited

心臓オルガノイドの作製・成熟化および医療応用への道筋
升本英利
第1回マルチモーダルECM Fusion Workshop - Designer Matrix and Organoid -, Jan. 2025, Invited

基調講演心臓と血管の病気をなおす再生医療のお話
升本英利
第1回 MERRO 東大寺奉納学術会議, Oct. 2024, Invited

一般セッション【産業化・標準化】バイオマテリアルを応用した心臓再生医療：標準化を目指して
升本英利
日本バイオマテリアル学会シンポジウム2024, Oct. 2024, Invited

心臓再生医療の進化と未来のビジョン
升本英利
2024 ライフサイエンスバイオマテリアル研究会, Sep. 2024, Invited

Pre-clinical studies of cardiac regeneration therapy by the transplantation of human pluripotent stem cell-derived cardiac microtissues
Masumoto H.
Virtual NGSP Symposium, Jun. 2024, Invited

Heart Organoids from Human iPS Cells and Clinical Translation
Masumoto H.
CuSTOM-RIKEN BDR WORKSHOP at CCHMC, Apr. 2024, Invited

心臓血管外科医によるiPS細胞研究の最前線～基礎から応用へ～
升本英利
第22回日本心臓血管外科再生治療研究会, Feb. 2024, Invited

iPS細胞を用いた心臓再生医療・創薬研究～iPS細胞による次世代の循環器病治療の実現をめざして～.
升本英利
【理化学研究所生命機能科学研究センター】共同研究・開発に向けた研究シーズマッチング（大阪府主催）, Jan. 2024, Invited

iPS細胞による次世代の循環器病治療の実現をめざして
升本英利
ECC-iCAP #16「ライフサイエンスが拓く未来社会」in東京, Dec. 2023, Invited

循環器医療研究におけるモデル生物の役割
升本英利
JoVEオンラインセミナー科学者に聞く～教育・研究現場でのモデル生物の今とこれから～, May 2023, Invited

ヒトiPS細胞を用いた心毒性評価および心臓病創薬のための高感度マイクロデバイス
升本英利
再生医療イノベーションフォーラム第15回ベンチャー創設支援フォーラム, Mar. 2023, Invited

3次元心筋組織を用いた再生医療開発
升本英利
第22回日本再生医療学会総会, Mar. 2023, Invited

心臓移植と再生医療のクロストーク
升本英利
第22回日本再生医療学会総会, Mar. 2023, Invited

Research for Cardiac Regenerative Medicine and Heart Diseases Using Pigs as a Large Mammal
升本英利
第86回日本循環器学会学術集会, Mar. 2022, Invited

モーニングセミナー重症心不全治療の現状と展望～多能性幹細胞への期待～
升本英利
第86回日本循環器学会学術集会, Mar. 2022, Invited

Organ-on-a-Chip を応用した心臓組織機能評価
升本英利
第21回日本再生医療学会総会, Mar. 2022, Invited

心血管系細胞多層体移植による心臓再生医療
升本英利
第21回日本再生医療学会総会, Mar. 2022, Invited

Human iPS cell-derived heart organoids and the medical application
Masumoto H.
Frontiers in Stem Cell & Organoid Medicine Symposium (CuSTOM-RIKEN joint symposium 2022), Mar. 2022, Invited

Cardiovascular Regenerative Medicine Based on Biomaterials: From Bench to Bedside
Masumoto H.
The 2nd ASEAN Japan International Conference on Innovative Biology Medicine and Engineering ICIBM, 2022, Invited

Cardiovascular Regenerative Medicine Supported by Biomaterials and Drug Delivery System
Masumoto H.
Controlled Release Society (CRS) Annual Meeting 2020, Dec. 2020, Invited

ヒトiPS細胞由来心血管系細胞多層体を用いた心不全治療法の開発
升本英利
第24回日本心不全学会学術集会, Oct. 2020, Invited

Heart Failure Treatment Using Engineered 3D Cardiac Sheets
升本英利
第84回日本循環器学会学術集会, Jul. 2020, Invited

共済セミナーヒトiPS細胞由来心血管系細胞多層体を用いた新たな重症心不全治療法
升本英利
第21回日本再生医療学会総会, Mar. 2020, Invited

特別講演 iPS細胞由来心血管系細胞を用いた心臓再生医療
升本英利
第33回日本冠疾患学会学術集会, Dec. 2019, Invited

Drug Delivery System-based Cardiovascular Regenerative Medicine: From Bench to Bedside
Masumoto H.
The 15th US-Japan Symposium on Drug Delivery Systems, Dec. 2019, Invited

iPS細胞から作製した人工心臓組織を用いた再生医療・疾患再現・創薬研究の試み
升本英利
兵庫県立こども病院-理化学研究所生命機能科学研究センター（BDR）第4回ジョイントシンポジウム, Dec. 2019, Invited

ヒトiPS細胞由来心血管系細胞多層体移植による心臓再生治療に向けた前臨床有効性試験
升本英利
第72回日本胸部外科学会定期学術集会, Oct. 2019, Invited

心臓血管領域再生医療の最前線
升本英利
第18回日本再生医療学会総会, Mar. 2019, Invited

ランチョンセミナー同種 iPS 細胞を用いた心不全治療を目指してこれからの心不全治療における iPS 細胞を用いた再生医療の役割
升本英利
第18回日本再生医療学会総会, Mar. 2019, Invited

Updates for Cardiovascular Regenerative Medicine Based on Biomaterials and Beyond (Luncheon Seminar)
Masumoto H.
The 5th Tissue Engineering and Regenerative Medicine International Society World Congress (TERMIS-WC), Sep. 2018, Invited

循環器領域におけるゼラチンハイドロゲルを用いた再生治療 -DDSから細胞治療まで-
升本英利
第17回日本再生医療学会総会, Mar. 2018, Invited

iPS細胞は外科の未来を変えるか？
升本英利
第84回日本循環器学会学術集会, Mar. 2018, Invited

The utilization of iPS cell-derived cardiac cell sheet
Masumoto H.
The 15th Workshop for the cutting-edge technologies in SPring-8, Aug. 2017, Invited

Three-dimensional heart tissues generated from human iPS cells for regenerative therapy and disease modeling
Masumoto H.
RIKEN CDB Seminar, Apr. 2017, Invited

Bioengineered Cardiac Cell Sheets. Stem Cells Summit: Integrative Models and Translation
Masumoto H.
American Heart Association (AHA) Scientific Sessions, Nov. 2016, Invited

Generation of 3-Dimensional Cardiac Tissue with human iPS Cells and Tissue Engineering
Masumoto H.
The 9th Pan Pacific Symposium on Stem Cells and Cancer Research, May 2016, Invited

Books and Other Publications

Animal Models and Experimental Research in Medicine
Osada H.; Murata K.; Masumoto H., Contributor, Large animal models in cardiovascular research
InTechOpen, 2022
Find Kyoto University's collection of books :

モデル動物の作製と利用－循環器疾患2021 ＜上巻＞
川東正英; 升本英利, Contributor, 第３節ラット：人工心肺
株式会社エル・アイ・シー, 2021
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Methods Mol Biol
Dwenger M.; Kowalski WJ; Masumoto H.; Nakane T.; Keller BB, Contributor, Chronic Optogenetic Pacing of Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
Humana, 2021
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Methods Mol Biol
Masumoto H., Contributor, Generation of Cylindrical Engineered Cardiac Tissues from Human iPS Cell-Derived Cardiovascular Cell Lineages
Humana, 2021
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Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
Ye F.; Setozaki S.; Kowalski WJ; Dwenger M.; Yuan F.; Tinney JP; Nakane T.; Masumoto H.; Keller BB, Contributor, Progress in the Generation of Multiple Lineage Human-iPSC- derived 3D Engineered Cardiac Tissues for Cardiac Repair
2020
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循環器疾患の最新医療
升本英利, Contributor, 心臓の再生医療
先端医療技術研究所, 2019
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Stem Cells in Clinical Practice and Tissue Engineering
Nakane, T.; Masumoto H.; Keller BB, Contributor, Human-Induced Pluripotent Stem Cell-Derived Engineered Cardiac Tissues
InTechOpen, 2018
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Annual Review循環器2016
升本英利, Contributor, 心臓再生医療の進歩
中外医学社, 2016

Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology
Keller BB; Ye F.; Yuan F.; Trada H.; Tinney JP; Walsh KM; Masumoto H., Contributor, Engineered Cardiac Tissues Generated from Immature Cardiac and Stem Cell-Derived Cells: Multiple Approaches and Outcomes
Tokyo: Springer, 2016

医学のあゆみ
升本英利, Contributor, iPS細胞からの心血管系への分化誘導
医歯薬出版, 2015

Pluripotent Stem Cells
Masumoto H.; Yamashita JK, Contributor, Pluripotent stem cells for cardiac cell therapy: the application of cell sheet technology. Pluripotent Stem Cells
InTechOpen, 2013
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Industrial Property Rights

特願2026-011193, 人工心臓組織の製造方法及び人工心臓組織
升本英利; 村田梢

特許第7783602号, 特願2022-557450, シート状物質を生体内に貼付するためのデバイス
升本英利; 長田裕明; 上杉昭二; 山下英樹; 安村直朗; 齋藤慶和; 加藤悠人

特許第7674714号, 特願JP2020041334, ハートオンチップデバイス並びにこれを用いた心臓機能の評価方法、薬剤スクリーニング方法及び心毒性評価試験方法
升本英利; 田中陽; アブラティ・モシャ; 村田梢; ヤリクン・ヤシャイラ; 佐藤麻子; 加藤謙介; 河原紀之

特願2024-184957, 多能性幹細胞に由来する血管内皮細胞の製造方法
升本英利; アブラティ・モシャ

PCT/JP2024/019642, 心筋細胞を成熟させる方法
升本英利; オスマン・マフムティ; 村田梢

特許第 5920741号, PCT/JP2013/058460, 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法
山下潤; 升本英利

Awards

09 Jun. 2012
第12回比叡山ﾜｰｸｼｮｯﾌﾟ最優秀賞(基礎研究部門)(京都大学医学部心臓血管外科同門会)

03 Jun. 2011
The Japanese Society of Inflammation and Regeneration, Poster Award, The 32nd Annual Meeting of Japanese Society of Inflammation and Regeneration

14 Jun. 2012
The Japanese Society for Regenerative Medicine, The most excellent prize, Basic research, The 4th Young Investigator’s Award, Japanese Society for Regenerative Medicine

06 Jul. 2012
The Japanese Society of Inflammation and Regeneration, The best poster award, The 33rd Annual Meeting of Japanese Society of Inflammation and Regeneration

15 Feb. 2013
Miyazaki Science Camp, Excellent prize, The 9th Miyazaki Science Camp

12 Feb. 2019
The Japanese Society for Cardiovascular Surgery, Most excellent prize, The 49th Annual Meeting of the Japanese Society for Cardiovascular Surgery

Media Coverage

【理研・京大プレスリリース】「植物に作らせた生理活性タンパク質が心臓再生医療を加速－植物発現システムによるサイトカインの安全な生産技術を開発－」
産経新聞朝刊, 毎日新聞夕刊, 日経新聞夕刊, 東京新聞朝刊, 神戸新聞夕刊, 共同通信等, Jun. 2025, Paper

【京大・理研プレスリリース】「iPS心組織で電気信号の流れを改善―ブタ心筋傷害モデルを用いた検討―」
京大・理研プレスリリース, Mar. 2025, Internet

「（扉）「ミニ臓器」オルガノイド、医療の光がん細胞を培養、仕組み解明・薬の開発に」
朝日新聞, 朝日新聞朝刊, Nov. 2024, Paper

【理研・京大プレスリリース】「「ポストコロナ」で警戒すべき心不全パンデミック－SARS-CoV-2の持続感染は心不全リスクを高める可能性－」
理研・京大プレスリリース, 毎日新聞, 神戸新聞, 共同通信等, Dec. 2023, Paper

【京大プレスリリース】「升本英利特定助教が日本で初めて世界的研究支援プログラムに選出されました」
京大プレスリリース, ノバルティスバイオメディカル研究所（NIBR）NIBR Global Scholars Program, Feb. 2023, Internet

【理研・京大プレスリリース】「安全な心臓血管手術のための人工冬眠の可能性－冬眠様状態の誘導により、虚血から臓器を保護できる－」
理研・京大プレスリリース, NHKニュース, ABEMAヒルズ, 朝日新聞, 日経新聞, 読売新聞, 京都新聞, 神戸新聞など, Nov. 2022, Paper

【理研プレスリリース】「iPS細胞でヒト心臓の機能を知る－ハートオンチップ型マイクロデバイスの開発－」
理研プレスリリース, 日刊工業新聞, 理研YouTubeチャンネル, Nov. 2020, Paper

【京大プレスリリース】「手術負担の少ない内視鏡による心臓表面への細胞シート移植デバイスを開発－心臓再生医療への応用を目指して－」
京大プレスリリース, 京都新聞, 産経新聞, 日刊工業新聞, 日本経済新聞, 読売テレビニュース, テレビ大阪ニュース, Nov. 2020, Paper

【京大プレスリリース】「ヒトiPS細胞から3次元的な心臓組織を作製し、致死性不整脈の複雑な特徴を培養下に再現することに成功」
京大プレスリリース, 朝日新聞, 京都新聞, 産経新聞, 中日新聞, 日刊工業新聞, 日本経済新聞, 毎日新聞, 読売新聞, Oct. 2017, Paper

【京大プレスリリース】「ヒトiPS細胞から高効率に血管細胞を作る方法を開発」
京大プレスリリース, 産経新聞, 毎日新聞, Mar. 2017, Paper

【京大プレスリリース】「心臓組織シートを、細胞が生きた状態で簡便に積層化する方法の開発」
京大プレスリリース, 京都新聞, 産経新聞, 日刊工業新聞, 日本経済新聞, 毎日新聞, 読売新聞, Nov. 2015, Paper

【京大プレスリリース】「ヒトiPS細胞から血管細胞を含む心臓組織シートを構築」
京大プレスリリース, 朝日新聞, 京都新聞, 産経新聞, 中日新聞, 日刊工業新聞, 日本経済新聞, 毎日新聞, 読売新聞, Oct. 2014, Paper

External funds: Kakenhi

iPS細胞由来成熟化心筋グラフト移植における電気生理学的同期に関する研究
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
武田崇秀
From 01 Apr. 2024, To 31 Mar. 2027, Granted
iPS細胞;三次元心臓組織;伝導障害
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K11991/

Establishment of a protocol for maturation of human iPS cell-derived 3D cardiac microtissue using a microgravity
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Institute of Physical and Chemical Research
村田梢
From 01 Apr. 2024, To 31 Mar. 2027, Granted
iPS細胞;心臓;成熟化;オルガノイド;微小重力
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K11982/

Development of a novel heart failure therapy by in vivo subtype modulation of macrophages using DDS
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
Takahide Takeda
From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
ドラッグデリバリーシステム;マクロファージ;心不全
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K09147/

Research on therapeutic application in the field of cardiovascular surgery by efficient introduction of microRNAs
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
Tadashi Ikeda
From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
マイクロRNA;ドラッグデリバリーシステム
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K09125/

Development of a highly sensitive detection and tumor removal system for tumor complications associated with iPS cell cardiac regenerative therapy
Grant-in-Aid for Scientific Research (B)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
Kenji Minatoya
From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
iPS細胞;心臓再生医療;MRI;腫瘍形成
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03764/

Mechanism of cardiomyocyte cell cycle regulation through stress response pathways
Grant-in-Aid for Scientific Research (B)
Basic Section 53020:Cardiology-related
Institute of Physical and Chemical Research
Wataru Kimura
From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
心筋梗塞;心筋再生;心筋細胞;AMPK;ストレス応答;細胞周期;酸化ストレス
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03680/

Research of disease modeling and drug discovery through the maturation regulation of human iPS cell-derived cardiac tissue recapitulating human heart function
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Institute of Physical and Chemical Research
Hidetoshi Masumoto
From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
iPS細胞;心臓再生医療;創薬研究;病態モデル;疾患再現;バイオマテリアル
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09281/

Research for the identification of biomarkers regarding the progression of cardiomyopathy based on imaging mass spectrometry and the therapeutic approach
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
Kazuhiro Yamazaki
From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
心筋症;蛋白解析;バイオマーカー;拡張型心筋症;イメージング質量分析
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09242/

Development of efficient organ protection during deep hypothermic circulatory arrest based on "artificial hibernation"
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
Masahide Kawatou
From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
人工冬眠;iPS細胞;大血管手術;低体温循環停止法;ヒトiPS細胞;病態モデル;能動的低代謝;臓器保護
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09241/

Development of a method of functional integration between host and graft on the transplantation therapy of human iPS cell-derived cardiac tissues
Grant-in-Aid for Scientific Research (B)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
Hideo Kanemitsu
From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
心臓再生医療;iPS細胞;バイオエンジニアリング;再生医学
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02887/

Development of self-growing vascular graft using decellularized vascular tissue and human iPS cell-derived vascular cells
Grant-in-Aid for Scientific Research (B)
Kyoto University
Tadashi Ikeda
From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
血管再生;iPS細胞;移植・再生医療;循環器・高血圧;再生医学;バイオテクノロジー;細胞・組織;再生医療;脱細胞グラフト;ヒトiPS細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04291/

Development of cardiomyopathy-specific iPS cell-derived 3-dimensional biomaterial-based cardiac tissues suitable for drug discovery
Grant-in-Aid for Scientific Research (C)
Institute of Physical and Chemical Research;Kyoto University
Hidetoshi Masumoto
From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
心臓再生医療;iPS細胞;バイオエンジニアリング;心筋疾患外科学;拡張型心筋症;再生医学;創薬研究;バイオマテリアル
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10626/

Research for prevention of complications in cardiovascular surgeries through regulating HMGB1
Grant-in-Aid for Scientific Research (C)
Kyoto University
Kyokun Uehara
From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
弁膜疾患外科学;人工心肺;全身性炎症反応症候群
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10625/

Development of the regulation of inflammation in the field of cardiovascular surgery using human iPS cell-derived mesenchymal stem cells
Grant-in-Aid for Scientific Research (B)
Kyoto University
Kazuhiro Yamazaki
From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
心筋疾患外科学;ヒトiPS細胞;間葉系幹細胞;循環器・高血圧;外科;移植・再生医療
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05424/

Development of a new vascular regenerative therapy for severe limb ischemia by the transplantation of human iPS cell-derived vascular cells
Grant-in-Aid for Scientific Research (C)
Kyoto University
RYUZO SAKATA
From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
末梢動脈外科学;iPS細胞;血管新生;血管内皮細胞;抹消動脈外科学
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10241/

Development of human iPS cell-derived multidisciplinary thick viable organized tissues aiming for myocardial regenerative therapy
Grant-in-Aid for Scientific Research (C)
Kyoto University
Tomohiro Nakata
From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
iPS細胞;バイオエンジニアリング;心臓再生;心筋疾患外科学;拡張型心筋症;バイトエンジニアリング
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10210/

Investigation for the attenuation of arrhythmia related to human iPS cell-based cardiac regenerative therapy
Grant-in-Aid for Scientific Research (C)
Kyoto University
Hisashi Sakaguchi
From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
iPS細胞;心筋梗塞;重症心不全;致死性不整脈;ホルター心電図;マイクロミニピッグ;心筋疾患外科学;致死的不整脈;プログラム電気刺激
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K10209/

多能性幹細胞による心筋再生治療実現のための集学的多層組織化移植片の構築
Grant-in-Aid for Scientific Research (C)
Kyoto University
升本英利
From 01 Apr. 2013, To 31 Mar. 2014, Discontinued
心筋再生;多能性幹細胞;細胞工学
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462137/

Drug discovery for the treatment of severe heart failure
Grant-in-Aid for Scientific Research (B)
Kyoto University
Hiroshi Tsuneyosi
From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
心筋疾患外科学;iPS細胞;創薬スクリーニング;心筋症;重症心不全;創薬研究
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293297/

ヒトiPS細胞由来間葉系細胞による心臓外科領域の全身炎症反応制御法の開発
Grant-in-Aid for Scientific Research (B)
Kyoto University
丸井晃
From 01 Apr. 2013, To 31 Mar. 2016, Adopted
間葉系幹細胞;抗炎症療法;iPS細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293296/

ミトコンドリアと細胞周期のクロストーク制御による心筋再生
Grant-in-Aid for Scientific Research (B)
Basic Section 53020:Cardiology-related
Institute of Physical and Chemical Research
木村航
From 01 Apr. 2024, To 31 Mar. 2026, Granted
心臓再生;細胞周期;ヌクレオチド代謝;心筋細胞;ミトコンドリア;AMPKシグナル;AMPK;心筋梗塞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27604/

心臓血管外科領域におけるiPS細胞技術を用いた新規遺伝子治療ベクターの開発
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
池田義
From 01 Apr. 2023, To 31 Mar. 2026, Granted
iPS細胞;マイクロRNA;ドラッグデリバリーシステム
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K08232/

Development of a Novel Cardiac Regenerative Therapy Using Human iPS Cell-Derived Cardiac Microtissues
Grant-in-Aid for Scientific Research (B)
Basic Section 55030:Cardiovascular surgery-related
Institute of Physical and Chemical Research
Hidetoshi Masumoto
From 01 Apr. 2024, To 31 Mar. 2025, Project Closed
iPS細胞;心臓再生医療;心臓オルガノイド
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24420/

Development of a humanized, self-growing vascular graft derived from xenogeneic animals using human iPS cells
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
The Tazuke Kofukai
Hideo Kanemitsu
From 01 Apr. 2022, To 31 Mar. 2025, Project Closed
iPS細胞;脱細胞組織;血管内皮細胞;人工血管;ヒトiPS細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08956/

ヒトiPS細胞由来人工心臓組織における成熟化プロセスの理解と制御法の確立
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
長田裕明
From 01 Apr. 2022, To 31 Mar. 2025, Discontinued
iPS細胞;心臓再生医療
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08934/

プロテオーム解析とiPS細胞モデルを用いた術後肺動静脈瘻発生関連因子に関する研究
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
井出雄二郎
From 01 Apr. 2022, To 31 Mar. 2024, Discontinued
先天性心疾患;肺動静脈瘻;病態モデル;iPS細胞;イメージング質量分析
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08918/

Development of a cardiotoxicity evaluation system using a Heart-on-a-Chip Microdevice with aligned fiber device.
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Institute of Physical and Chemical Research;Kyoto University
Kozue Murata
From 01 Apr. 2021, To 31 Mar. 2024, Project Closed
iPS細胞;心臓;オルガノイド;組織;心毒性;HMD;Organ-on-a-chip;創薬研究
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08861/

Comprehensive Platform for Studying Molecular Mechanisms Regulating Cardiomyocyte Maturation
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
Medium-sized Section 53:Organ-based internal medicine and related fields
Jichi Medical University
Hideki Uosaki
From 07 Oct. 2019, To 31 Mar. 2025, Project Closed
心筋細胞;成熟;iPS細胞;転写因子;心臓発生;比較トランスクリプトーム;心臓;発生・発達;多能性幹細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19KK0219/

iPS細胞由来人工心臓組織移植における腫瘍性合併症の早期診断および治療法の開発
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
湊谷謙司
From 01 Apr. 2025, To 31 Mar. 2028, Granted
iPS細胞
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K12090/

ヒトiPS細胞由来人工心臓組織への階層的血管網形成および再生医療応用に関する研究
Grant-in-Aid for Scientific Research (C)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
高井文恵
From 01 Apr. 2025, To 31 Mar. 2028, Granted
iPS細胞;心臓オルガノイド;心臓再生医療;創薬研究
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K12047/

拡張型心筋症患者由来iPS細胞を用いた三次元マイクロ心臓組織の開発と応用
Grant-in-Aid for Scientific Research (B)
Basic Section 55030:Cardiovascular surgery-related
Kyoto University
松尾武彦
From 01 Apr. 2025, To 31 Mar. 2028, Granted
iPS細胞;疾患再現;拡張型心筋症;創薬研究
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K02724/

External funds: others

Novartis Pharma AG, NIBR Global Scholars Program
From 01 Jan. 2023, To 31 Dec. 2025
Hidetoshi Masumoto

Study of a newly designed high-performance membrane oxygenator equipped with both local temperature control technology and non-fouling technology
日本医療研究開発機構（AMED）医療分野研究成果展開事業先端計測分析技術・機器開発プログラム
From 22 Jun. 2020, To 31 Mar. 2023
織田　禎二

Study of immunological rejection related to iPS cell-derived artificial heart tissue transplantation for cardiac regenerative medicine
日本医療研究開発機構（AMED）再生医療実現拠点ネットワークプログラム（技術開発個別課題）
From 01 Oct. 2018, To 31 Mar. 2021
湊谷　謙司

Development of a new surgical device for less-invasive transplantation of iPS cell-derived cardiac tissues
京都大学産官学連携本部　GAPファンドプログラム
From 01 Mar. 2019, To 29 Feb. 2020
升本　英利

Research for identification of pathology-associated biomarkers of dilated cardiomyopathy model hamsters
材料科学技術振興財団　共同研究
From 01 Jan. 2019, To 31 Dec. 2019
升本　英利

Development of technologies to establish functional tissue based on tissue engineering
日本医療研究開発機構(AMED)　未来医療を実現する医療機器・システム研究開発事業
From 01 Apr. 2018, To 31 Mar. 2019
田畑　泰彦

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Masumoto, Hidetoshi

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