Basic Information

Faculty

• 薬学部

Professional Memberships

• From Apr. 2017, To Present

  日本筋学会
• From Apr. 2003, To Present

  日本薬学会
• From Oct. 1995, To Present

  Biophysical Society
• 日本生化学会

Academic Degree

• 農学修士(東京農工大学)
• 医学博士(京都大学)

Research History

• From 2000, To 2001

  Kurume University, Institute of Life Science
• From 2000, To 2001

  Kurume University, Institute of Life Science, Professor
• From 2001

  - 東北大学 医学部 教授
• From 2001

  - Tohoku University, Faculty of medicine, Professor
• From 1995, To 2000

  The University of Tokyo, Faculty of Medicine
• From 1995, To 2000

  University of Tokyo, Faculty of medicine, Assistant Professor
• From 1994, To 1995

  Saitama Medical University
• From 1994, To 1995

  Saitama Medical School, Lecturer
• From 1989, To 1992

  Kyoto University, Faculty of Medicine
• From 1989, To 1992

  Kyoto University, Faculty of medicine, Instructor
• Kyoto University
• Former Institution /Organization Tohoku University Graduate School of Medicine Department of Medical Sciences, Professor

Language of Instruction

• English

ID,URL

• J-Global ID

  200901021344500822

researchmap URL

• https://researchmap.jp/read0075699

Research

Research Topics, Overview of the research

• Research Topics

  Intracellular Ca2+ stores

• Overview of the research

  Ca2+ release from the endo/sarcoplasmic reticulum (ER/SR) controls important cellular functions including muscle contraction, neurotransmitter release, membrane potential regulation. Although Ca2+ store functions in the ER/SR are constituted and further modulated by many proteins, such mechanisms are largely unknown at the molecular level. We focus on the ER/SR in excitable cell type and attempt to identify the roles of their protein components towards understanding the molecular basis of Ca2+ stores. Results from our studies contribute to both identifying target proteins for drug development and unveiling pathological mechanisms in genetic and metabolic diseases.

Research Interests

• Ca2+シグナル 興奮性細胞
• excitable cells
• Ca2+ signal

Research Areas

• Life sciences, Medical biochemistry

Papers

• Non-physiologic interaction of MG53 with insulin receptor and lack of evidence for MG53’s role in controlling insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues

  Kyung Eun Lee; Miyuki Nishi; Jongsoo Kim; Takashi Murayama; Zachary Dawson; Xiaoliang Wang; Xinyu Zhou; Tao Tan; Chuanxi Cai; Hiroshi Takeshima; Ki Ho Park

  30 Jan. 2024

  
• The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2

  Jianshu Hu; Elisa Venturi; Charalampos Sigalas; Takashi Murayama; Miyuki Nishi; Hiroshi Takeshima; Rebecca Sitsapesan

  Journal of General Physiology, 06 Nov. 2023

  
• Atypical cell death and insufficient matrix organization in long-bone growth plates from Tric-b-knockout mice

  Atsuhiko Ichimura; Yuu Miyazaki; Hiroki Nagatomo; Takaaki Kawabe; Nobuhisa Nakajima; Ga Eun Kim; Masato Tomizawa; Naoki Okamoto; Shinji Komazaki; Sho Kakizawa; Miyuki Nishi; Hiroshi Takeshima

  Cell Death & Disease, 20 Dec. 2023

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• 生体防御機構におけるイオンチャネル機能研究の新展開と創薬 酸化的ストレス感受性Ca2+チャネルTRPM2の免疫応答細胞における生理的役割

  山本 伸一郎; 清水 俊一; 清中 茂樹; 高橋 重成; 竹島 浩; 森 泰生

  日本薬学会年会要旨集, Mar. 2010

  
• Extraocular muscle function is impaired in ryr3(-/-) mice

  Jan Eckhardt; Christoph Bachmann; Marijana Sekukc-Jablanovic; Volker Enzmann; Ki Ho Park; Jianjie Ma; Hiroshi Takeshima; Francesco Zorzato; Susan Treves

  JOURNAL OF GENERAL PHYSIOLOGY, Jul. 2019, Peer-reviewed

  
• C型ナトリウム利尿ペプチドは軟骨細胞内Ca2+シグナル経路を活性化し骨伸長を促進する

  岡本 直樹; 市村 敦彦; 宮崎 侑; 北山 諒; 安江 智己; 劉 楓; 川邊 隆彰; 長友 宏樹; 柿澤 昌; 西 美幸; 竹島 浩

  日本薬学会年会要旨集, Mar. 2022

  
• Enhanced Ca²⁺ handling in thioglycolate-elicited peritoneal macrophages

  Feng Liu; Luxin Xu; Miyuki Nishi; Atsuhiko Ichimura; Hiroshi Takeshima

  Cell Calcium, Jun. 2021

  
• SERCA2aの発現および活性の低下による老化関連心機能障害においてsarcalumeninは重要な役割をもつ(Sarcalumenin Plays a Critical Role in Age-related Cardiac Dysfunction due to Decreases in SERCA2a Expression and Activity)

  Jiao Qibin; Akaike Toru; Takeshima Hiroshi; Ishikawa Yoshihiro; Minamisawa Susumu

  Circulation Journal, Mar. 2010

  
• 筋小胞体内カルシウム結合蛋白質sarcalumenin欠損マウスの心機能に与える加齢などの生理学的ストレスの影響(The effect of physiological stresses such as aging on cardiac function in sarcalumenin-deficient mice)

  Jiao Qibin; Shimura Miei; Akaike Toru; Takeshima Hiroshi; Ishikawa Yoshihiro; Minamisawa Susumu

  The Journal of Physiological Sciences, Apr. 2008

  
• Ryanodine receptor type 3 does not contribute to contractions in the mouse myometrium regardless of pregnancy

  Katsuhito Matsuki; Masashi Takemoto; Yoshiaki Suzuki; Hisao Yamamura; Susumu Ohya; Hiroshi Takeshima; Yuji Imaizumi

  PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Feb. 2017, Peer-reviewed

  
• C-type natriuretic peptide facilitates autonomic Ca2+ entry in growth plate chondrocytes for stimulating bone growth

  Yuu Miyazaki; Atsuhiko Ichimura; Ryo Kitayama; Naoki Okamoto; Tomoki Yasue; Feng Liu; Takaaki Kawabe; Hiroki Nagatomo; Yohei Ueda; Ichiro Yamauchi; Takuro Hakata; Kazumasa Nakao; Sho Kakizawa; Miyuki Nishi; Yasuo Mori; Haruhiko Akiyama; Kazuwa Nakao; Hiroshi Takeshima

  eLife, 15 Mar. 2022, Peer-reviewed

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• カウンターイオンチャネルTRIC-Bの欠損はマウス成長板軟骨細胞において形態異常を引き起こす

  宮崎 侑; 市村 敦彦; 北山 諒; 辻本 真人; 山崎 大樹; 西 美幸; 竹島 浩

  日本薬学会年会要旨集, Mar. 2020

  
• TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle

  Zhou Xinyu; Ki Ho Park; Daiju Yamazaki; Lin Pei-hui; Miyuki Nishi; Ma Zhiwei; Qiu Liming; Takashi Murayama; Zou Xiaoqin; Hiroshi Takeshima; Zhou Jingsong; Ma Jianjie

  CIRCULATION RESEARCH, Feb. 2020

  
• Calcium phosphate mineralization in bone tissues directly observed in aqueous liquid by atmospheric SEM (ASEM) without staining: microfluidics crystallization chamber and immuno-EM.

  Chikara Sato; Daiju Yamazaki; Mari Sato; Hiroshi Takeshima; Nassirhadjy Memtily; Yuri Hatano; Takayuki Tsukuba; Eiko Sakai

  Scientific reports, 14 May 2019

  
• TRPM7 channels mediate spontaneous Ca²⁺ fluctuations in growth plate chondrocytes that promote bone development.

  Qian N; Ichimura A; Takei D; Sakaguchi R; Kitani A; Nagaoka R; Tomizawa M; Miyazaki Y; Miyachi H; Numata T; Kakizawa S; Nishi M; Mori Y; Takeshima H

  Science signaling, Apr. 2019, Peer-reviewed

  
• Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle

  Katsuhito Matsuki; Daiki Kato; Masashi Takemoto; Yoshiaki Suzuki; Hisao Yamamura; Susumu Ohya; Hiroshi Takeshima; Yuji Imaizumi

  American Journal of Physiology-Cell Physiology, Jul. 2018, Peer-reviewed

  
• Gm7325 Transcription Is Regulated by MyoD in Activated Muscle Satellite Cells

  Daisuke Takei; Miyuki Nishi; So-ichiro Fukada; Masao Doi; Hitoshi Okamura; Akiyoshi Uezumi; Lidan Zhang; Morikatsu Yoshida; Mikiya Miyazato; Atsuhiko Ichimura; Hiroshi Takeshima

  Biophysical Journal, Feb. 2018, Peer-reviewed

  
• Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage

  Benedict Reilly-O'Donnell; Gavin B. Robertson; Angela Karumbi; Connor McIntyre; Wojciech Bal; Miyuki Nishi; Hiroshi Takeshima; Alan J. Stewart; Samantha J. Pitt

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2017, Peer-reviewed

  
• Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A

  Sam El-Ajouz; Elisa Venturi; Katja Witschas; Matthew Beech; Abigail D. Wilson; Chris Lindsay; David Eberhardt; Fiona O'Brien; Tsunaki Iida; Miyuki Nishi; Hiroshi Takeshima; Rebecca Sitsapesan

  JOURNAL OF PHYSIOLOGY-LONDON, Jul. 2017, Peer-reviewed

  
• 病理学 TRIC-B遺伝子変異による骨形成不全症

  市村 敦彦; 趙 成珠; 竹島 浩

  医学のあゆみ, Feb. 2017, Peer-reviewed

  
• Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.

  Daisuke Takei; Miyuki Nishi; So-Ichiro Fukada; Masao Doi; Hitoshi Okamura; Akiyoshi Uezumi; Lidan Zhang; Morikatsu Yoshida; Mikiya Miyazato; Atsuhiko Ichimura; Hiroshi Takeshima

  Biomedical research (Tokyo, Japan), 2017

  
• TRIC-B Mutations Causing Osteogenesis Imperfecta

  Atsuhiko Ichimura; Hiroshi Takeshima

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2016, Peer-reviewed

  
• Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.

  Zhao C; Ichimura A; Qian N; Iida T; Yamazaki D; Noma N; Asagiri M; Yamamoto K; Komazaki S; Sato C; Aoyama F; Sawaguchi A; Kakizawa S; Nishi M; Takeshima H

  Science signaling, May 2016, Peer-reviewed

  
• Junctophilin-4, a component of the endoplasmic reticulum-plasma membrane junctions, regulates Ca2+ dynamics in T cells

  Jin Seok Woo; Sonal Srikanth; Miyuki Nishi; Peipei Ping; Hiroshi Takeshima; Yousang Gwack

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2016, Peer-reviewed

  
• A Role of TMEM16E Carrying a Scrambling Domain in Sperm Motility.

  Gyobu S; Miyata H; Ikawa M; Yamazaki D; Takeshima H; Suzuki J; Nagata S

  Molecular and cellular biology, Dec. 2015, Peer-reviewed

  
• Mitsugumin 56 (hedgehog acyltransferase-like) is a sarcoplasmic reticulum-resident protein essential for postnatal muscle maturation

  Van Bo; Nishi Miyuki; Komazaki Shinji; Ichimura Atsuhiko; Kakizawa Sho; Nakanaga Keita; Aoki Junken; Park Ki-Ho; Ma Jianjie; Ueyama Tomomi; Ogata Takehiro; Maruyama Naoki; Takeshima Hiroshi

  FEBS LETTERS, 28 Apr. 2015, Peer-reviewed

  
• Aberrant behavioral sensitization by methamphetamine in junctophilin deficient mice.

  Shigeki Moriguchi; Miyuki Nishi; Yuzuru Sasaki; Hiroshi Takeshima; Kohji Fukunaga

  Mol. Neurobiol., 2015, Peer-reviewed

  
• Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice.

  Nakao A; Miki T; Shoji H; Nishi M; Takeshima H; Miyakawa T; Mori Y

  Frontiers in behavioral neuroscience, 2015, Peer-reviewed

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• A Novel Calcium-Mobilizing Mechanism Mediated by S-nitrosylation-Dependent Modulation of Ryanodine Receptor

  Kakizawa S; Takeshima H; Iino M

  Meesenger, 2012, Peer-reviewed, Invited

  
• Real time analysis of sarcolemmal repair mediated by dysferlin and MG53

  Matsuda C; Miyake K; Kameyama K; Takeshima H; Keduka E; Araki N; Nishino I; Hayashi Y. K

  NEUROMUSCULAR DISORDERS, Oct. 2011, Peer-reviewed

  
• Mitsugumin23, a Protein Associated with Intracellular Calcium Stores, Behaves as an Ion-Channel that can Conduct Calcium

  Elisa Venturi; Kazuhiro Mio; Miyuki Nishi; Toshihiko Ogura; Toshio Moriya; Samantha J. Pitt; Kazutaka Okuda; Rebecca Sitsapesan; Chikara Sato; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Feb. 2011, Peer-reviewed

  
• Working mechanism of flubendiamide, a novel ryanodine receptor activator

  Yuichi Sawaguchi; Yusuke Mizuno; Kenta Kato; Shigeki Kiyonaka; Emiko Mori; Takao Masaki; Hiroshi Takeshima; Yasuo Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Peer-reviewed

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• Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence

  Ueda, H.; Inoue, M.; Takeshima, H.; Iwasawa, Y.

  Journal of Neuroscience, 2000, Peer-reviewed

  
• cDNA cloning and regional distribution of a novel member of the opioid receptor family

  K. Fukuda; S. Kato; K. Mori; M. Nishi; H. Takeshima; N. Iwabe; T. Miyata; T. Houtani; T. Sugimoto

  FEBS Letters, 18 Apr. 1994, Peer-reviewed

  
• Trimeric Intracellular Cation Channels and Sarcoplasmic/Endoplasmic Reticulum Calcium Homeostasis

  Xinyu Zhou; Peihui Lin; Daiju Yamazaki; Ki Ho Park; Shinji Komazaki; S. R. Wayne Chen; Hiroshi Takeshima; Jianjie Ma

  CIRCULATION RESEARCH, Feb. 2014, Peer-reviewed

  
• TRIC-B channels display labile gating: Evidence from the TRIC-A knockout mouse model

  Elisa Venturi; Antoni Matyjaszkiewicz; Samantha J. Pitt; Krasimira Tsaneva-Atanasova; Miyuki Nishi; Daiju Yamazaki; Hiroshi Takeshima; Rebecca Sitsapesan

  Pflugers Archiv European Journal of Physiology, Aug. 2013, Peer-reviewed

  
• Facilitated Hyperpolarization Signaling in Vascular Smooth Muscle-overexpressing TRIC-A Channels

  Shengchen Tao; Daiju Yamazaki; Shinji Komazaki; Chengzhu Zhao; Tsunaki Iida; Sho Kakizawa; Yuji Imaizumi; Hiroshi Takeshima

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2013, Peer-reviewed

  
• Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice

  Barbara Mosca; Osvaldo Delbono; Maria Laura Messi; Leda Bergamelli; Zhong-Min Wang; Mirko Vukcevic; Ruben Lopez; Susan Treves; Miyuki Nishi; Hiroshi Takeshima; Cecilia Paolini; Marta Martini; Giorgio Rispoli; Feliciano Protasi; Francesco Zorzato

  NATURE COMMUNICATIONS, Feb. 2013, Peer-reviewed

  
• TRIC channels supporting efficient Ca2+ release from intracellular stores

  Elisa Venturi; Rebecca Sitsapesan; Daiju Yamazaki; Hiroshi Takeshima

  PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Feb. 2013, Peer-reviewed

  
• [TRIC channel and hypertension].

  D. Yamazaki; S. Tao; H. Takeshima

  Clinical calcium, 2013, Peer-reviewed

  
• The C2A domain in dysferlin is important for association with MG53 (TRIM72).

  Chie Matsuda; Katsuya Miyake; Kimihiko Kameyama; Etsuko Keduka; Hiroshi Takeshima; Toru Imamura; Nobukazu Araki; Ichizo Nishino; Yukiko Hayashi

  PLoS currents, 05 Nov. 2012, Peer-reviewed

  
• TRIM50 Protein Regulates Vesicular Trafficking for Acid Secretion in Gastric Parietal Cells

  Miyuki Nishi; Fumiyo Aoyama; Fumihiko Kisa; Hua Zhu; Mingzhai Sun; Peihui Lin; Hiroya Ohta; Bo Van; Shinichiro Yamamoto; Sho Kakizawa; Hideki Sakai; Jianjie Ma; Akira Sawaguchi; Hiroshi Takeshima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2012, Peer-reviewed

  
• Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

  Noah Weisleder; Norio Takizawa; Peihui Lin; Xianhua Wang; Chunmei Cao; Yan Zhang; Tao Tan; Christopher Ferrante; Hua Zhu; Pin-Jung Chen; Rosalie Yan; Matthew Sterling; Xiaoli Zhao; Moonsun Hwang; Miyuki Takeshima; Chuanxi Cai; Heping Cheng; Hiroshi Takeshima; Rui-Ping Xiao; Jianjie Ma

  SCIENCE TRANSLATIONAL MEDICINE, Jun. 2012, Peer-reviewed

  
• Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair

  Peihui Lin; Hua Zhu; Chuanxi Cai; Xianhua Wang; Chunmei Cao; Ruiping Xiao; Zui Pan; Noah Weisleder; Hiroshi Takeshima; Jianjie Ma

  FASEB JOURNAL, May 2012, Peer-reviewed

  
• Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging

  Osvaldo Delbono; Maria Laura Messi; Zhong-Min Wang; Susan Treves; Barbara Mosca; Leda Bergamelli; Miyuki Nishi; Hiroshi Takeshima; Hang Shi; Bingzhong Xue; Francesco Zorzato

  EXPERIMENTAL GERONTOLOGY, Apr. 2012, Peer-reviewed

  
• Loss of junctophilin-3 contributes to huntington disease-like 2 pathogenesis

  Ana I. Seixas; Susan E. Holmes; Hiroshi Takeshima; Amira Pavlovich; Nancy Sachs; Jennifer L. Pruitt; Isabel Silveira; Christopher A. Ross; Russell L. Margolis; Dobrila D. Rudnicki

  ANNALS OF NEUROLOGY, Feb. 2012, Peer-reviewed

  
• Loss of junctophilin-3 contributes to huntington disease-like 2 pathogenesis

  Ana I. Seixas; Susan E. Holmes; Hiroshi Takeshima; Amira Pavlovich; Nancy Sachs; Jennifer L. Pruitt; Isabel Silveira; Christopher A. Ross; Russell L. Margolis; Dobrila D. Rudnicki

  ANNALS OF NEUROLOGY, Feb. 2012, Peer-reviewed

  
• Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function

  Sho Kakizawa; Toshiko Yamazawa; Yili Chen; Akihiro Ito; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Osamu Sato; Masahiko Watanabe; Nozomu Mori; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Nobuhito Saito; Masamitsu Iino

  EMBO JOURNAL, Jan. 2012, Peer-reviewed

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• The C2A domain in dysferlin is important for association with MG53 (TRIM72).

  Chie Matsuda; Katsuya Miyake; Kimihiko Kameyama; Etsuko Keduka; Hiroshi Takeshima; Toru Imamura; Nobukazu Araki; Ichizo Nishino; Yukiko Hayashi

  PLoS currents, 05 Nov. 2012, Peer-reviewed

  
• Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity

  Qibin Jiao; Hiroshi Takeshima; Yoshihiro Ishikawa; Susumu Minamisawa

  CELL CALCIUM, Jan. 2012, Peer-reviewed

  
• Ryanodine Receptor Type 2 Is Required for the Development of Pressure Overload-Induced Cardiac Hypertrophy

  Yunzeng Zou; Yanyan Liang; Hui Gong; Ning Zhou; Hong Ma; Aili Guan; Aijun Sun; Ping Wang; Yuhong Niu; Hong Jiang; Hiroyuki Takano; Haruhiro Toko; Atsushi Yao; Hiroshi Takeshima; Hiroshi Akazawa; Ichiro Shiojima; Yuqi Wang; Issei Komuro; Junbo Ge

  HYPERTENSION, Dec. 2011, Peer-reviewed

  
• TRIC-A Channels in Vascular Smooth Muscle Contribute to Blood Pressure Maintenance

  Daiju Yamazaki; Yasuharu Tabara; Satomi Kita; Hironori Hanada; Shinji Komazaki; Daisuke Naitou; Aya Mishima; Miyuki Nishi; Hisao Yamamura; Shinichiro Yamamoto; Sho Kakizawa; Hitoshi Miyachi; Shintaro Yamamoto; Toshiyuki Miyata; Yuhei Kawano; Kei Kamide; Toshio Ogihara; Akira Hata; Satoshi Umemura; Masayoshi Soma; Norio Takahashi; Yuji Imaizumi; Tetsuro Miki; Takahiro Iwamoto; Hiroshi Takeshima

  CELL METABOLISM, Aug. 2011, Peer-reviewed

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• Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair

  Moonsun Hwang; Jae-Kyun Ko; Noah Weisleder; Hiroshi Takeshima; Jianjie Ma

  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Jul. 2011, Peer-reviewed

  
• Mitsugumin 23 Forms a Massive Bowl-Shaped Assembly and Cation-Conducting Channel

  Elisa Venturi; Kazuhiro Mio; Miyuki Nishi; Toshihiko Ogura; Toshio Moriya; Samantha J. Pitt; Kazutaka Okuda; Sho Kakizawa; Rebecca Sitsapesan; Chikara Sato; Hiroshi Takeshima

  BIOCHEMISTRY, Apr. 2011, Peer-reviewed

  
• Polymerase Transcriptase Release Factor (PTRF) Anchors MG53 Protein to Cell Injury Site for Initiation of Membrane Repair

  Hua Zhu; Peihui Lin; Gejing De; Kyoung-han Choi; Hiroshi Takeshima; Noah Weisleder; Jianjie Ma

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2011, Peer-reviewed

  
• Molecular architecture of Ca2+ signaling control in muscle and heart cells

  Xiaoli Zhao; Daiju Yamazaki; Sho Kakizawa; Zui Pan; Hiroshi Takeshima; Jianjie Ma

  CHANNELS, Sep. 2011, Peer-reviewed

  
• Impaired Orai1-mediated Resting Ca2+ Entry Reduces the Cytosolic [Ca2+] and Sarcoplasmic Reticulum Ca2+ Loading in Quiescent Junctophilin 1 Knock-out Myotubes

  Hongli Li; Xudong Ding; Jose R. Lopez; Hiroshi Takeshima; Jianjie Ma; Paul D. Allen; Jose M. Eltit

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2010, Peer-reviewed

  
• Ca2+ Overload and Sarcoplasmic Reticulum Instability in tric-a Null Skeletal Muscle

  Xiaoli Zhao; Daiju Yamazaki; Ki Ho Park; Shinji Komazaki; Andoria Tjondrokoesoemo; Miyuki Nishi; Peihui Lin; Yutaka Hirata; Marco Brotto; Hiroshi Takeshima; Jianjie Ma

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2010, Peer-reviewed

  
• Charade of the SR K+-Channel: Two Ion-Channels, TRIC-A and TRIC-B, Masquerade as a Single K+-Channel

  Samantha J. Pitt; Ki-Ho Park; Miyuki Nishi; Toshiki Urashima; Sae Aoki; Daijyu Yamazaki; Jianjie Ma; Hiroshi Takeshima; Rebecca Sitsapesan

  BIOPHYSICAL JOURNAL, Jul. 2010, Peer-reviewed

  
• Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair

  Xianhua Wang; Wenjun Xie; Yi Zhang; Peihui Lin; Liang Han; Peidong Han; Yanru Wang; Zheng Chen; Guangju Ji; Ming Zheng; Noah Weisleder; Rui-Ping Xiao; Hiroshi Takeshima; Jianjie Ma; Heping Cheng

  CIRCULATION RESEARCH, Jul. 2010, Peer-reviewed

  
• MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning

  Chun-Mei Cao; Yan Zhang; Noah Weisleder; Christopher Ferrante; Xianhua Wang; Fengxiang Lv; Yi Zhang; Ruisheng Song; Moonsun Hwang; Li Jin; Jiaojiao Guo; Wei Peng; Geng Li; Miyuki Nishi; Hiroshi Takeshima; Jianjie Ma; Rui-Ping Xiao

  CIRCULATION, Jun. 2010, Peer-reviewed

  
• Nociceptin and its metabolite attenuate U0126-induced memory impairment through a nociceptin opioid peptide (NOP) receptor-independent mechanism

  Masaya Miwa; Shogo Uchida; Fumika Horiba; Hiroshi Takeshima; Toshitaka Nabeshima; Masayuki Hiramatsu

  NEUROBIOLOGY OF LEARNING AND MEMORY, Mar. 2010, Peer-reviewed

  
• Facilitation of DNA damage-induced apoptosis by endoplasmic reticulum protein mitsugumin23

  Tetsuo Yamazaki; Nozomi Sasaki; Miyuki Nishi; Hiroshi Takeshima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2010, Peer-reviewed

  
• TRIC (trimeric intracellular cation) - Channel functions during Ca ²⁺ release from the sarco/endoplasmic reticulum

  D. Yamazaki; S. Yamamoto; H. Takeshima

  Folia Pharmacologica Japonica, 2010, Peer-reviewed

  
• Molecular Characterization of Flubendiamide Sensitivity in the Lepidopterous Ryanodine Receptor Ca2+ Release Channel

  Kenta Kato; Shigeki Kiyonaka; Yuichi Sawaguchi; Masanori Tohnishi; Takao Masaki; Noriaki Yasokawa; Yusuke Mizuno; Emiko Mori; Keisuke Inoue; Itaru Hamachi; Hiroshi Takeshima; Yasuo Mori

  BIOCHEMISTRY, Nov. 2009, Peer-reviewed

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• Sarcalumenin is essential for maintaining cardiac function during endurance exercise training

  Qibin Jiao; Yunzhe Bai; Toru Akaike; Hiroshi Takeshima; Yoshihiro Ishikawa; Susumu Minamisawa

  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, Aug. 2009, Peer-reviewed

  
• Essential role of the TRIC-B channel in Ca2+ handling of alveolar epithelial cells and in perinatal lung maturation

  Daiju Yamazaki; Shinji Komazaki; Hiroki Nakanishi; Aya Mishima; Miyuki Nishi; Masayuki Yazawa; Tetsuo Yamazaki; Ryo Taguchi; Hiroshi Takeshima

  DEVELOPMENT, Jul. 2009, Peer-reviewed

  
• Membrane Repair Defects in Muscular Dystrophy Are Linked to Altered Interaction between MG53, Caveolin-3, and Dysferlin

  Chuanxi Cai; Noah Weisleder; Jae-Kyun Ko; Shinji Komazaki; Yoshihide Sunada; Miyuki Nishi; Hiroshi Takeshima; Jianjie Ma

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2009, Peer-reviewed

  
• Protein Kinase C-epsilon Regulates Local Calcium Signaling in Airway Smooth Muscle Cells

  Qing-Hua Liu; Yun-Min Zheng; Amit S. Korde; Xiao-Qiang Li; Jianjie Ma; Hiroshi Takeshima; Yong-Xiao Wang

  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Jun. 2009, Peer-reviewed

  
• Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair

  Noah Weisleder; Hiroshi Takeshima; Jianjie Ma

  Communicative and Integrative Biology, May 2009, Peer-reviewed

  
• New molecular components supporting ryanodine receptor-mediated Ca2+ release: Roles of junctophilin and TRIC channel in embryonic cardiomyocytes

  Daiju Yamazaki; Tetsuo Yamazaki; Hiroshi Takeshima

  PHARMACOLOGY & THERAPEUTICS, Mar. 2009, Peer-reviewed

  
• Genetic evidence for functional role of ryanodine receptor 1 in pulmonary artery smooth muscle cells

  Xiao-Qiang Li; Yun-Min Zheng; Rakesh Rathore; Jianjie Ma; Hiroshi Takeshima; Yong-Xiao Wang

  PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Feb. 2009, Peer-reviewed

  
• MG53 Regulates Membrane Budding and Exocytosis in Muscle Cells

  Chuanxi Cai; Haruko Masumiya; Noah Weisleder; Zui Pan; Miyuki Nishi; Shinji Komazaki; Hiroshi Takeshima; Jianjie Ma

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2009, Peer-reviewed

  
• Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes

  Haruko Masumiya; Yasuhide Asaumi; Miyuki Nishi; Susumu Minamisawa; Satomi Adachi-Akahane; Morikatsu Yoshida; Kenji Kangawa; Kenta Ito; Yutaka Kagaya; Teruyuki Yanagisawa; Tetsuo Yamazaki; Jianjie Ma; Hiroshi Takeshima

  CHANNELS, Jan. 2009, Peer-reviewed

  
• Physiological functions of TRIC channels

  Daiju Yamazaki; Tetsuo Yamazaki; Hiroshi Takeshima

  Seikagaku, 2009, Peer-reviewed

  
• Molecular Characterization of Flubendiamide Sensitivity in the Lepidopterous Ryanodine Receptor Ca2+ Release Channel

  Kenta Kato; Shigeki Kiyonaka; Yuichi Sawaguchi; Masanori Tohnishi; Takao Masaki; Noriaki Yasokawa; Yusuke Mizuno; Emiko Mori; Keisuke Inoue; Itaru Hamachi; Hiroshi Takeshima; Yasuo Mori

  BIOCHEMISTRY, Nov. 2009, Peer-reviewed

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• MG53 nucleates assembly of cell membrane repair machinery

  Chuanxi Cai; Haruko Masumiya; Noah Weisleder; Noriyuki Matsuda; Miyuki Nishi; Moonsun Hwang; Jae-Kyun Ko; Peihui Lin; Angela Thornton; Xiaoli Zhao; Zui Pan; Shinji Komazaki; Marco Brotto; Hiroshi Takeshima; Jianjie Ma

  NATURE CELL BIOLOGY, Jan. 2009, Peer-reviewed

  
• Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests

  Naoki Matsuo; Koichi Tanda; Kazuo Nakanishi; Nobuyuki Yamasaki; Keiko Toyama; Keizo Takao; Hiroshi Takeshima; Tsuyoshi Miyakawa

  FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2009, Peer-reviewed

  
• Functional Crosstalk Between Cell-Surface and Intracellular Channels Mediated by Junctophilins Essential for Neuronal Functions

  Sho Kakizawa; Shigeki Moriguchi; Atsushi Ikeda; Masamitsu Iino; Hiroshi Takeshima

  CEREBELLUM, Sep. 2008, Peer-reviewed

  
• TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

  Shinichiro Yamamoto; Shunichi Shimizu; Shigeki Kiyonaka; Nobuaki Takahashi; Teruaki Wajima; Yuji Hara; Takaharu Negoro; Toshihito Hiroi; Yuji Kiuchi; Takaharu Okada; Shuji Kaneko; Ingo Lange; Andrea Fleig; Reinhold Penner; Miyuki Nishi; Hiroshi Takeshima; Yasuo Mori

  NATURE MEDICINE, Jul. 2008, Peer-reviewed

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• Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP

  Richard Stewart; Lele Song; Simon M. Carter; Charalambos Sigalas; Nathan R. Zaccai; Venkateswarlu Kanamarlapudi; Manjunatha B. Bhat; Hiroshi Takeshima; Rebecca Sitsapesan

  JOURNAL OF MEMBRANE BIOLOGY, Mar. 2008, Peer-reviewed

  
• Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK

  A. Tara Huddleston; Wei Tang; Hiroshi Takeshima; Susan L. Hamilton; Eric Klann

  JOURNAL OF NEUROPHYSIOLOGY, Mar. 2008, Peer-reviewed

  
• Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice

  Atsushi Sasaki; Ichiro Takasaki; Tsugunobu Andoh; Kimiyasu Shiraki; Hiroshi Takeshima; Hiroki Takahata; Yasushi Kuraishi

  NEUROREPORT, Jan. 2008, Peer-reviewed

  
• Sarcalumenin alleviates stress-induced cardiac dysfunction by improving Ca2+ handling of the sarcoplasmic reticulum

  Miei Shimura; Susumu Minamisawa; Hiroshi Takeshima; Qibin Jiao; Yunzhe Bai; Satoshi Umemura; Yoshihiro Ishikawa

  CARDIOVASCULAR RESEARCH, Jan. 2008, Peer-reviewed

  
• Immuno-proteomic approach to excitation-contraction coupling in skeletal and cardiac muscle: Molecular insights revealed by the mitsugurnins

  Noah Weisleder; Hiroshi Takeshima; Jianjie Ma

  CELL CALCIUM, Jan. 2008, Peer-reviewed

  
• Systemic ablation of RyR3 alters Ca2+ spark signaling in adult skeletal muscle

  Noah Weisleder; Christopher Ferrante; Yutaka Hirata; Claude Collet; Yi Chu; Heping Cheng; Hiroshi Takeshima; Jianjie Ma

  CELL CALCIUM, Dec. 2007, Peer-reviewed

  
• Abnormal features in mutant cerebellar Purkinje cells lacking junctophilins

  Atsushi Ikeda; Taisuke Miyazaki; Sho Kakizawa; Yasushi Okuno; Soken Tsuchiya; Akira Myomoto; Shin-Ya Saito; Tetsuji Yamamoto; Tetsuo Yamazaki; Masamitsu Iino; Gozoh Tsujimoto; Masahiko Watanabe; Hiroshi Takeshima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2007, Peer-reviewed

  
• Augmentation of drug-induced cell death by ER protein BRI3BP

  Tetsuo Yamazaki; Nozomi Sasaki; Miyuki Nishi; Daiju Yamazaki; Atsushi Ikeda; Yasushi Okuno; Shinji Komazaki; Hiroshi Takeshima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2007, Peer-reviewed

  
• Ryanodine receptor type 2 deficiency changes excitation-contraction coupling and membrane potential in urinary bladder smooth muscle

  Shingo Hotta; Kozo Morimura; Susumu Ohya; Katsuhiko Muraki; Hiroshi Takeshima; Yuji Imaizumi

  JOURNAL OF PHYSIOLOGY-LONDON, Jul. 2007, Peer-reviewed

  
• TRIC channels are essential for Ca2+ handling in intracellular stores

  Masayuki Yazawa; Christopher Ferrante; Jue Feng; Kazuhiro Mio; Toshihiko Ogura; Miao Zhang; Pei-Hui Lin; Zui Pan; Shinji Komazaki; Kazuhiro Kato; Miyuki Nishi; Xiaoli Zhao; Noah Weisleder; Chikara Sato; Jianjie Ma; Hiroshi Takeshima

  NATURE, Jul. 2007, Peer-reviewed

  
• Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum

  Miao Zhang; Tetsuo Yamazaki; Masayuki Yazawa; Susan Treves; Miyuki Nishi; Machiko Murai; Eisuke Shibata; Francesco Zorzato; Hiroshi Takeshima

  CELL CALCIUM, Jul. 2007, Peer-reviewed

  
• Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity

  Sho Kakizawa; Yasushi Kishimoto; Kouichi Hashimoto; Taisuke Miyazaki; Kazuharu Furutani; Hidemi Shimizu; Masahiro Fukaya; Miyuki Nishi; Hiroyuki Sakagami; Atsushi Ikeda; Hisatake Kondo; Masanobu Kano; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima

  EMBO JOURNAL, Apr. 2007, Peer-reviewed

  
• Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task

  Jun Nagai; Mamoru Kurokawa; Hiroshi Takeshima; Brigitte L. Kieffer; Hiroshi Ueda

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Apr. 2007, Peer-reviewed

  
• Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyRl) channel complex is mediated by their hyper-reactive thiols

  Andrew J. Phimister; Jozsef Lango; Eun Hui Lee; Michael A. Ernst-Russell; Hiroshi Takeshima; Jianjie Ma; Paul D. Allen; Isaac N. Pessah

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2007, Peer-reviewed

  
• ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle

  Kazuko Miyakawa; Ayumi Uchida; Tomomi Shiraki; Koji Teshima; Hiroshi Takeshima; Shigenobu Shibata

  NEUROPHARMACOLOGY, Mar. 2007, Peer-reviewed

  
• Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy

  Yoshihisa Matsushita; T. Furukawa; H. Kasanuki; M. Nishibatake; Y. Kurihara; A. Ikeda; N. Kamatani; H. Takeshima; R. Matsuoka

  JOURNAL OF MEDICAL GENETICS, Sep. 2007, Peer-reviewed

  
• Mg2+ activates the ryanodine receptor type 2 (RyR2) at intermediate Ca2+ concentrations

  Akihito Chugun; Osamu Sato; Hiroshi Takeshima; Yasuo Ogawa

  AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Jan. 2007, Peer-reviewed

  
• The involvement of the nociceptin receptor in the antinociceptive action of nitrous oxide

  Shugaku Himukashi; Hiroshi Takeshima; Sahoko Koyanagi; Tsutomu Shichino; Kazuhiko Fukuda

  ANESTHESIA AND ANALGESIA, Sep. 2006, Peer-reviewed

  
• Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release

  Noah Weisleder; Marco Brotto; Shinji Komazaki; Zui Pan; Xiaoli Zhao; Thomas Nosek; Jerome Parness; Hiroshi Takeshima; Jianjie Ma

  JOURNAL OF CELL BIOLOGY, Aug. 2006, Peer-reviewed

  
• Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family

  Taisuke Miyazaki; Kouichi Hashimoto; Atsushi Uda; Hiroyuki Sakagami; Yoshitaka Nakamura; Shin-ya Saito; Miyuki Nishi; Hideaki Kume; Akira Tohgo; Izumi Kaneko; Hisatake Kondo; Kohji Fukunaga; Masanobu Kano; Masahiko Watanabe; Hiroshi Takeshima

  FEBS LETTERS, Jul. 2006, Peer-reviewed

  
• Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes

  Y Hirata; M Brotto; N Weisleder; Y Chu; PH Lin; XL Zhao; A Thornton; S Komazaki; H Takeshima; JJ Ma; Z Pan

  BIOPHYSICAL JOURNAL, Jun. 2006, Peer-reviewed

  
• Impaired cerebellar functions in mutant mice lacking DNER

  A Tohgo; M Eiraku; T Miyazaki; E Miura; S Kawaguchi; M Nishi; M Watanabe; T Hirano; M Kengaku; H Takeshima

  MOLECULAR AND CELLULAR NEUROSCIENCE, Feb. 2006, Peer-reviewed

  
• The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E-2-induced allodynia, tactile pain associated with nerve injury

  E Okuda-Ashitaka; T Minami; S Matsumura; H Takeshima; RK Reinscheid; O Civelli; S Ito

  EUROPEAN JOURNAL OF NEUROSCIENCE, Feb. 2006, Peer-reviewed

  
• DNER as key molecule for cerebellar maturation

  Shin-Ya Saito; Hiroshi Takeshima

  CEREBELLUM, 2006, Peer-reviewed

  
• Erratum: Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells (Journal of Neurochemistry (2005) 93 (674-85))

  Shigetsune Matsuya; Hiroyuki Sakagami; Akira Tohgo; Yuji Owada; Hye-Won Shin; Hiroshi Takeshima; Kazuhisa Nakayama; Shoichi Kokubun; Hisatake Kondo

  Journal of Neurochemistry, Nov. 2005, Peer-reviewed

  
• Enhanced resistance to fatigue and altered calcium handling properties of sarcalumenin knockout mice

  XL Zhao; M Yoshida; L Brotto; H Takeshima; N Weisleder; Y Hirata; TM Nosek; JJ Ma; M Brotto

  PHYSIOLOGICAL GENOMICS, Sep. 2005, Peer-reviewed

  
• Nociceptin system does not affect MAC of volatile anaesthetics

  S Himukashi; Y Miyazaki; H Takeshima; S Koyanagi; K Mukaida; T Shichino; H Uga; K Fukuda

  ACTA ANAESTHESIOLOGICA SCANDINAVICA, Jul. 2005, Peer-reviewed

  
• Enhanced hippocampal acetylcholine release in nociceptin-receptor knockout mice

  K Uezu; A Sano; H Sei; K Toida; T Houtani; T Sugimoto; T Suzuki-Yamamoto; H Takeshima; K Ishimura; Y Morita

  BRAIN RESEARCH, Jul. 2005, Peer-reviewed

  
• Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation

  FA Taverna; J Georgiou; RJ McDonald; NS Hong; A Kraev; MW Salter; H Takeshima; RU Muller; JC Roder

  JOURNAL OF PHYSIOLOGY-LONDON, Jun. 2005, Peer-reviewed

  
• Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells

  S Matsuya; H Sakagami; A Tohgo; Y Owada; HW Shin; H Takeshima; K Nakayama; S Kokubun; H Kondo

  JOURNAL OF NEUROCHEMISTRY, May 2005, Peer-reviewed

  
• Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice

  M Yoshida; S Minamisawa; M Shimura; S Komazaki; H Kume; M Zhang; K Matsumura; M Nishi; M Saito; Y Saeki; Y Ishikawa; T Yanagisawa; H Takeshima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2005, Peer-reviewed

  
• Methamphetamine sensitization in nociceptin receptor knockout mice: locomotor and c-fos expression

  C Okabe; H Takeshima; NP Murphy

  EUROPEAN JOURNAL OF PHARMACOLOGY, Jan. 2005, Peer-reviewed

  
• Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies

  S Minamisawa; J Oshikawa; H Takeshima; M Hoshijima; YB Wang; KR Chien; Y Ishikawa; R Matsuoka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2004, Peer-reviewed

  
• Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice

  MAP Brotto; RY Nagaraj; LS Brotto; H Takeshima; JJ Ma; TM Nosek

  CELL RESEARCH, Oct. 2004, Peer-reviewed

  
• Intradermal nociceptin elicits itch-associated responses through leukotriene B-4 in mice

  T Andoh; Y Yageta; H Takeshima; Y Kuraishi

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Jul. 2004, Peer-reviewed

  
• Co-expression of MG29 and ryanodine receptor leads to apoptotic cell death - Effect mediated by intracellular Ca2+ release

  Z Pan; Y Hirata; RY Nagaraj; JY Zhao; M Nishi; SM Hayek; MB Bhat; H Takeshima; JJ Ma

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2004, Peer-reviewed

  
• Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis

  T Sakakibara; Y Nemoto; T Nukiwa; H Takeshima

  FEBS LETTERS, May 2004, Peer-reviewed

  
• Exogenous, but not endogenous nociceptin modulates mesolimbic dopamine release in mice

  M Koizumi; N Midorikawa; H Takeshima; NP Murphy

  JOURNAL OF NEUROCHEMISTRY, Apr. 2004, Peer-reviewed

  
• Lack of nociceptin receptor alters body temperature during resting period in mice

  K Uezu; H Sei; A Sano; K Toida; T Suzuki-Yamamoto; T Houtani; T Sugimoto; H Takeshima; K Ishimura; Y Morita

  NEUROREPORT, Apr. 2004, Peer-reviewed

  
• Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors

  K Lutfy; S Eitan; CD Bryant; YC Yang; N Saliminejad; W Walwyn; BL Kieffer; H Takeshima; FI Carroll; NT Maidment; CJ Evans

  JOURNAL OF NEUROSCIENCE, Nov. 2003, Peer-reviewed

  
• Changes in Ca2+ handling in adult MG29-deficient skeletal muscle

  N Kurebayashi; H Takeshima; M Nishi; T Murayama; E Suzuki; Y Ogawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2003, Peer-reviewed

  
• Coexpression of junctophilin type 3 and type 4 in brain

  M Nishi; H Sakagami; S Komazaki; H Kondo; H Takeshima

  MOLECULAR BRAIN RESEARCH, Oct. 2003, Peer-reviewed

  
• Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor

  UB Depner; RK Reinscheid; H Takeshima; K Brune; HU Zeilhofer

  EUROPEAN JOURNAL OF NEUROSCIENCE, Jun. 2003, Peer-reviewed

  
• Abnormal junctional membrane structures in cardiac myocytes expressing ectopic junctophilin type 1

  S Komazaki; M Nishi; H Takeshima

  FEBS LETTERS, May 2003, Peer-reviewed

  
• In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord

  M Inoue; T Kawashima; H Takeshima; G Calo; A Inoue; Y Nakata; H Ueda

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, May 2003, Peer-reviewed

  
• A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene

  T Houtani; M Ikeda; M Kase; K Sato; S Sakuma; S Kakimoto; T Ueyama; Y Munemoto; H Takeshima; T Sugimoto

  NEUROSCIENCE LETTERS, Jan. 2003, Peer-reviewed

  
• Ryanodine receptor and junctional membrane structure

  Hiroshi Takeshima

  Folia Pharmacologica Japonica, 2003, Peer-reviewed

  
• Delta/Notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like ReDeat-cont ining protein T ryeted to dendrites of developing and adult central nervous system neurons

  M Eiraku; Y Hirata; H Takeshima; T Hirano; M Kengaku

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2002, Peer-reviewed

  
• Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1

  S Komazaki; K Ito; H Takeshima; H Nakamura

  FEBS LETTERS, Jul. 2002, Peer-reviewed

  
• Dysfunction of store-operated calcium channel in muscle cells lacking mg29

  Z Pan; DM Yang; RY Nararaj; TA Nosek; M Nishi; H Takeshima; HP Cheng; JJ Ma

  NATURE CELL BIOLOGY, May 2002, Peer-reviewed

  
• Essential immunoregulatory role for BCAP in B cell development and function

  T Yamazaki; K Takeda; K Gotoh; H Takeshima; S Akira; T Kurosaki

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2002, Peer-reviewed

  
• A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory

  GA Higgins; JNC Kew; JG Richards; H Takeshima; F Jenck; G Adam; J Wichmann; JA Kemp; AJ Grottick

  EUROPEAN JOURNAL OF NEUROSCIENCE, Mar. 2002, Peer-reviewed

  
• Motor discoordination in mutant mice lacking junctophilin type 3

  M Nishi; K Hashimoto; K Kuriyama; S Komazaki; M Kano; S Shibata; H Takeshima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2002, Peer-reviewed

  
• Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells

  A Uehara; M Yasukochi; Imanaga, I; M Nishi; H Takeshima

  CELL CALCIUM, Feb. 2002, Peer-reviewed

  
• Intracellular Ca2+ store in embryonic cardiac myocytes

  H Takeshima

  FRONTIERS IN BIOSCIENCE, Jul. 2002, Peer-reviewed

  
• Abnormal formation of sarcoplasmic reticulum networks and triads during early development of skeletal muscle cells in mitsugumin29-deficient mice

  S Komazaki; M Nishi; H Takeshima; H Nakamura

  DEVELOPMENT GROWTH & DIFFERENTIATION, Dec. 2001, Peer-reviewed

  
• Important role of junctophilin in nematode motor function

  M Yoshida; A Sugimoto; Y Ohshima; H Takeshima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2001, Peer-reviewed

  
• Brainstem auditory regions in mice: expression of nociceptin/orphanin FQ precursor mRNA in select neurons

  S Kakimoto; T Houtani; K Sato; T Ueyama; S Sakuma; Y Munemoto; H Ohishi; M Kase; T Yamashita; H Takeshima; T Sugimoto

  NEUROSCIENCE LETTERS, Nov. 2001, Peer-reviewed

  
• RyR3 amplifies RyR1-mediated Ca2+-induced Ca2+ release in neonatal mammalian skeletal muscle

  DM Yang; Z Pan; H Takeshima; CH Wu; RY Nagaraj; JJ Ma; HP Cheng

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2001, Peer-reviewed

  
• Pronociceptive effects of nociceptin/orphanin FQ (13-17) at peripheral and spinal level in mice

  M Inoue; S Matsunaga; MH Rashid; A Yoshida; K Mizuno; T Sakurada; H Takeshima; H Ueda

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Oct. 2001, Peer-reviewed

  
• Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1

  K Ito; S Komazaki; K Sasamoto; M Yoshida; M Nishi; K Kitamura; H Takeshima

  JOURNAL OF CELL BIOLOGY, Sep. 2001, Peer-reviewed

  
• Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function

  GA Higgins; AJ Grottick; TM Ballard; JG Richards; J Messer; H Takeshima; M Pauly-Evers; F Jenck; G Adam; J Wichmann

  NEUROPHARMACOLOGY, Jul. 2001, Peer-reviewed

  
• In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated [S-35]GTP gamma S binding to mouse brain

  D Ichikawa; S Ozaki; T Azuma; H Nambu; H Kawamoto; Y Iwasawa; H Takeshima; H Ohta

  NEUROREPORT, Jun. 2001, Peer-reviewed

  
• Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor

  M Shimuta; M Yoshikawa; M Fukaya; M Watanabe; H Takeshima; T Manabe

  MOLECULAR AND CELLULAR NEUROSCIENCE, May 2001, Peer-reviewed

  
• Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor

  S Ahmadi; C Kotalla; H Guhring; H Takeshima; A Pahl; HU Zeilhofer

  MOLECULAR PHARMACOLOGY, Mar. 2001, Peer-reviewed

  
• Ryanodine receptors and intracellular Ca2+ stores

  H Takeshima

  SEIKAGAKU, Jan. 2001, Peer-reviewed

  
• Morphine tolerance and dependence in the nociceptin receptor knockout mice

  T Mamiya; Y Noda; Ren, X; T Nagai; H Takeshima; M Ukai; T Nabeshima

  JOURNAL OF NEURAL TRANSMISSION, 2001, Peer-reviewed

  
• Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene

  RY Nagaraj; CM Nosek; MAP Brotto; M Nishi; H Takeshima; TM Nosek; JJ Ma

  PHYSIOLOGICAL GENOMICS, Nov. 2000, Peer-reviewed

  
• Characterization of a calcium-regulation domain of the skeletal-muscle ryanodine receptor

  SM Hayek; XS Zhu; MB Bhat; JY Zhao; H Takeshima; HH Valdivia; JJ Ma

  BIOCHEMICAL JOURNAL, Oct. 2000, Peer-reviewed

  
• A region of the sulfonylurea receptor critical for a modulation of ATP-sensitive K+ channels by G-protein beta gamma-subunits

  Y Wada; T Yamashita; K Imai; R Miura; K Takao; M Nishi; H Takeshima; T Asano; R Morishita; K Nishizawa; S Kokubun; T Nukada

  EMBO JOURNAL, Sep. 2000, Peer-reviewed

  
• Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: A study using in situ hybridization and X-gal histochemistry in receptor-deficient mice

  T Houtani; M Nishi; H Takeshima; K Sato; S Sakuma; S Kakimoto; T Ueyama; T Noda; T Sugimoto

  JOURNAL OF COMPARATIVE NEUROLOGY, Aug. 2000, Peer-reviewed

  
• Characterization of human junctophilin subtype genes

  M Nishi; A Mizushima; K Nakagawara; H Takeshima

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2000, Peer-reviewed

  
• Role of nociceptin systems in learning and memory

  Y Noda; T Mamiya; T Manabe; M Nishi; H Takeshima; T Nabeshima

  PEPTIDES, Jul. 2000, Peer-reviewed

  
• Junctophilins: A novel family of junctional membrane complex proteins

  H Takeshima; S Komazaki; M Nishi; M Lino; K Kangawa

  MOLECULAR CELL, Jul. 2000, Peer-reviewed

  
• Comparison of Ca2+ sparks produced independently by two ryanodine receptor isoforms (type 1 or type 3)

  MW Conklin; CA Ahern; P Vallejo; Sorrentino, V; H Takeshima; R Coronado

  BIOPHYSICAL JOURNAL, Apr. 2000, Peer-reviewed

  
• Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus

  Y Kouzu; T Moriya; H Takeshima; T Yoshioka; S Shibata

  MOLECULAR BRAIN RESEARCH, Mar. 2000, Peer-reviewed

  
• Molecular cloning of cDNA encoding a Drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel

  XH Xu; MB Bhat; M Nishi; H Takeshima; JJ Ma

  BIOPHYSICAL JOURNAL, Mar. 2000, Peer-reviewed

  
• Abnormal features in skeletal muscle from mice lacking mitsugumin29

  M Nishi; S Komazaki; N Kurebayashi; Y Ogawa; T Noda; M Iino; H Takeshima

  JOURNAL OF CELL BIOLOGY, Dec. 1999, Peer-reviewed

  
• Involvement of ryanodine receptor type 3 in dopamine release from the striatum: Evidence from mutant mice lacking this receptor

  K Wan; T Moriya; M Akiyama; H Takeshima; S Shibata

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1999, Peer-reviewed

  
• A negatively charged region of the skeletal muscle ryanodine receptor is involved in Ca2+-dependent regulation of the Ca2+ release channel

  SM Hayek; JY Zhao; M Bhat; XH Xu; R Nagaraj; Z Pan; H Takeshima; JJ Ma

  FEBS LETTERS, Nov. 1999, Peer-reviewed

  
• Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord

  M Inoue; Shimohira, I; A Yoshida; A Zimmer; H Takeshima; T Sakurada; H Ueda

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Oct. 1999, Peer-reviewed

  
• Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers

  BE Flucher; A Conti; H Takeshima; Sorrentino, V

  JOURNAL OF CELL BIOLOGY, Aug. 1999, Peer-reviewed

  
• Expression and functional characterization of the cardiac muscle ryanodine receptor Ca2+ release channel in Chinese hamster ovary cells

  MB Bhat; SM Hayek; JY Zhao; WJ Zang; H Takeshima; WG Wier; JJ Ma

  BIOPHYSICAL JOURNAL, Aug. 1999, Peer-reviewed

  
• Immunolocalization of mitsugumin29 in developing skeletal muscle and effects of the protein expressed in amphibian embryonic cells

  S Komazaki; M Nishi; K Kangawa; H Takeshima

  DEVELOPMENTAL DYNAMICS, Jun. 1999, Peer-reviewed

  
• Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns

  K Hirose; S Kadowaki; M Tanabe; H Takeshima; M Iino

  SCIENCE, May 1999, Peer-reviewed

  
• Fluorescent indicators for inositol 1,4,5-trisphosphate based on bioconjugates of pleckstrin homology domain and fluorescent dyes

  K Hirose; H Takeshima; M Iino

  ANALYTICAL COMMUNICATIONS, May 1999, Peer-reviewed

  
• Nociceptin system plays a role in the memory retention: involvement of naloxone benzoylhydrazone binding sites

  T Mamiya; Y Noda; M Nishi; H Takeshima; T Nabeshima

  NEUROREPORT, Apr. 1999, Peer-reviewed

  
• RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells

  M Nishi; H Takeshima; T Houtani; K Nakagawara; T Noda; T Sugimoto

  MOLECULAR BRAIN RESEARCH, Apr. 1999, Peer-reviewed

  
• Contractile function is unaltered in diaphragm from mice lacking calcium release channel isoform 3

  JS Clancy; H Takeshima; SL Hamilton; MB Reid

  AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, Oct. 1999, Peer-reviewed

  
• Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3

  T Ikemoto; H Takeshima; M Iino; M Endo

  PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Dec. 1998, Peer-reviewed

  
• Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors

  S Komazaki; T Ikemoto; H Takeshima; M Iino; M Endo; H Nakamura

  CELL AND TISSUE RESEARCH, Dec. 1998, Peer-reviewed

  
• Facilitation of long-term potentiation and memory in mice lacking nociception receptors

  T Manabe; Y Noda; T Mamiya; H Katagiri; T Houtani; M Nishi; T Noda; T Takahashi; T Sugimoto; T Nabeshima; H Takeshima

  NATURE, Aug. 1998, Peer-reviewed

  
• Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes

  M Nishi; S Komazaki; M Iino; K Kangawa; H Takeshima

  FEBS LETTERS, Aug. 1998, Peer-reviewed

  
• Structure and expression of mitsugumin29 gene

  M Shimuta; S Komazaki; M Nishi; M Iino; K Nakagawara; H Takeshima

  FEBS LETTERS, Jul. 1998, Peer-reviewed

  
• Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice

  Y Noda; T Mamiya; T Nabeshima; M Nishi; M Higashioka; H Takeshima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1998, Peer-reviewed

  
• Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2

  H Takeshima; S Komazaki; K Hirose; M Nishi; T Noda; M Lino

  EMBO JOURNAL, Jun. 1998, Peer-reviewed

  
• Mitsugumin29, a novel synaptophysin family member from the triad junction in skeletal muscle

  H Takeshima; M Shimuta; S Komazaki; K Ohmi; M Nishi; M Iino; A Miyata; K Kangawa

  BIOCHEMICAL JOURNAL, Apr. 1998, Peer-reviewed

  
• Enhancement of spatial attention in nociceptin orphanin FQ receptor knockout mice

  T Mamiya; Y Noda; M Nishi; H Takeshima; T Nabeshima

  BRAIN RESEARCH, Feb. 1998, Peer-reviewed

  
• Nociceptin and nociceptin receptor

  M Nishi; H Takeshima

  SEIKAGAKU, Jul. 1998, Peer-reviewed

  
• Caffeine-induced release of intracellular Ca2+ from Chinese hamster ovary cells expressing skeletal muscle ryanodine receptor - Effects on full-length and carboxyl-terminal portion of Ca2+ release channels

  B Manjunatha; JY Zhao; WJ Zang; CW Balke; H Takeshima; WG Wier; JJ Ma

  JOURNAL OF GENERAL PHYSIOLOGY, Dec. 1997, Peer-reviewed

  
• Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene

  H Ueda; T Yamaguchi; S Tokuyama; M Inoue; M Nishi; H Takeshima

  NEUROSCIENCE LETTERS, Nov. 1997, Peer-reviewed

  
• Deletion of amino acids 1641-2437 from the foot region of skeletal muscle ryanodine receptor alters the conduction properties of the Ca release channel

  MB Bhat; JY Zhao; S Hayek; EC Freeman; H Takeshima; JJ Ma

  BIOPHYSICAL JOURNAL, Sep. 1997, Peer-reviewed

  
• Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor

  MB Bhat; JY Zhao; H Takeshima; JJ Ma

  BIOPHYSICAL JOURNAL, Sep. 1997, Peer-reviewed

  
• Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 And type 3 ryanodine receptors

  T Ikemoto; S Komazaki; H Takeshima; M Nishi; T Noda; M Iino; M Endo

  JOURNAL OF PHYSIOLOGY-LONDON, Jun. 1997, Peer-reviewed

  
• Ca2+-induced Ca2+ release in Chinese hamster ovary (CHO) cells co-expressing dihydropyridine and ryanodine receptors

  N Suda; D Franzius; A Fleig; S Nishimura; M Bodding; M Hoth; H Takeshima; R Penner

  JOURNAL OF GENERAL PHYSIOLOGY, May 1997, Peer-reviewed

  
• Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

  M Nishi; T Houtani; Y Noda; T Mamiya; K Sato; T Doi; J Kuno; H Takeshima; T Nukada; T Nabeshima; T Yamashita; T Noda; T Sugimoto

  EMBO JOURNAL, Apr. 1997, Peer-reviewed

  
• A region of the ryanodine receptor critical for excitation-contraction coupling in skeletal muscle

  Toshiko Yamazawa; Hiroshi Takeshima; Misa Shimuta; Masamitsu Iino

  Journal of Biological Chemistry, 28 Mar. 1997, Peer-reviewed

  
• Ryanodine receptor

  H. Takeshima

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 1997, Peer-reviewed

  
• Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: Its involvement in allodynic response to innocuous stimulus

  E OkudaAshitaka; S Tachibana; T Houtani; T Minami; Y Masu; M Nishi; H Takeshima; T Sugimoto; S Ito

  MOLECULAR BRAIN RESEARCH, Dec. 1996, Peer-reviewed

  
• Subtype specificity of the ryanodine receptor for Ca2+ signal amplification in excitation-contraction coupling

  T Yamazawa; H Takeshima; T Sakurai; M Endo; M Iino

  EMBO JOURNAL, Nov. 1996, Peer-reviewed

  
• Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor

  A Fleig; H Takeshima; R Penner

  JOURNAL OF PHYSIOLOGY-LONDON, Oct. 1996, Peer-reviewed

  
• Generation and characterization of mutant mice lacking ryanodine receptor type 3

  H Takeshima; T Ikemoto; M Nishi; N Nishiyama; M Shimuta; Y Sugitani; J Kuno; Saito, I; H Saito; M Endo; M Iino; T Noda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1996, Peer-reviewed

  
• Structure and regional distribution of nociceptin/orphanin FQ precursor

  T Houtani; M Nishi; H Takeshima; T Nukada; T Sugimoto

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 1996, Peer-reviewed

  
• OPIOID MU-RECEPTOR AND KAPPA-RECEPTOR MEDIATE PHOSPHOLIPASE-C ACTIVATION THROUGH GI1 IN XENOPUS OOCYTES

  H UEDA; T MIYAMAE; N FUKUSHIMA; H TAKESHIMA; K FUKUDA; Y SASAKI; Y MISU

  MOLECULAR BRAIN RESEARCH, Aug. 1995, Peer-reviewed

  
• CA2+-INDUCED CA2+ RELEASE IN MYOCYTES FROM DYSPEDIC MICE LACKING THE TYPE-1 RYANODINE RECEPTOR

  H TAKESHIMA; T YAMAZAWA; T IKEMOTO; H TAKEKURA; M NISHI; T NODA; M LINO

  EMBO JOURNAL, Jul. 1995, Peer-reviewed

  
• APPROACH TO THE ROLE OF RYANODINE RECEPTORS USING MICE WITH A TARGETED MUTATION

  H TAKESHIMA

  SEIKAGAKU, Apr. 1995, Peer-reviewed

  
• STRUCTURE AND CHROMOSOMAL MAPPING OF GENES FOR THE MOUSE KAPPA-OPIOID RECEPTOR AND AN OPIOID RECEPTOR HOMOLOG (MOR-C)

  M NISHI; H TAKESHIMA; M MORI; K NAKAGAWARA; T TAKEUCHI

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1994, Peer-reviewed

  
• MULTIPLE TYPES OF RYANODINE RECEPTOR CA2+ RELEASE CHANNELS ARE DIFFERENTIALLY EXPRESSED IN RABBIT BRAIN

  T FURUICHI; D FURUTAMA; Y HAKAMATA; J NAKAI; H TAKESHIMA; K MIKOSHIBA

  JOURNAL OF NEUROSCIENCE, Aug. 1994, Peer-reviewed

  
• MU-OPIOID RECEPTOR - EXPRESSION AND VAGOTOMY-INDUCED DEPLETION OF THE MESSENGER-RNA IN MEDULLARY PREGANGLIONIC NEURONS

  T HOUTANI; T UEYAMA; H TAKESHIMA; S KATO; K FUKUDA; K MORI; T SUGIMOTO

  MOLECULAR BRAIN RESEARCH, Jul. 1994, Peer-reviewed

  
• EXCITATION-CONTRACTION UNCOUPLING AND MUSCULAR DEGENERATION IN MICE LACKING FUNCTIONAL SKELETAL-MUSCLE RYANODINE-RECEPTOR GENE

  H TAKESHIMA; M IINO; H TAKEKURA; M NISHI; J KUNO; O MINOWA; H TAKANO; T NODA

  NATURE, Jun. 1994, Peer-reviewed

  
• ISOLATION AND CHARACTERIZATION OF A GENE FOR A RYANODINE RECEPTOR CALCIUM-RELEASE CHANNEL IN DROSOPHILA-MELANOGASTER

  H TAKESHIMA; M NISHI; N IWABE; T MIYATA; T HOSOYA; MASAI, I; Y HOTTA

  FEBS LETTERS, Jan. 1994, Peer-reviewed

  
• CDNA CLONING AND PHARMACOLOGICAL CHARACTERIZATION OF AN OPIOID RECEPTOR WITH HIGH AFFINITIES FOR KAPPA-SUBTYPE-SELECTIVE LIGANDS

  M NISHI; H TAKESHIMA; K FUKUDA; S KATO; K MORI

  FEBS LETTERS, Sep. 1993, Peer-reviewed

  
• PRIMARY STRUCTURES AND EXPRESSION FROM CDNAS OF RAT OPIOID RECEPTOR DELTA-SUBTYPES AND MU-SUBTYPES

  K FUKUDA; S KATO; K MORI; M NISHI; H TAKESHIMA

  FEBS LETTERS, Aug. 1993, Peer-reviewed

  
• REQUIREMENT OF THE CALCIUM-CHANNEL BETA-SUBUNIT FOR FUNCTIONAL CONFORMATION

  S NISHIMURA; H TAKESHIMA; F HOFMANN; FLOCKERZI, V; K IMOTO

  FEBS LETTERS, Jun. 1993, Peer-reviewed

  
• A BRAIN-SPECIFIC TRANSCRIPT FROM THE 3'-TERMINAL REGION OF THE SKELETAL-MUSCLE RYANODINE RECEPTOR GENE

  H TAKESHIMA; S NISHIMURA; M NISHI; M IKEDA; T SUGIMOTO

  FEBS LETTERS, May 1993, Peer-reviewed

  
• Primary Structure and Expression from cDNAs of the Ryanodine Receptor

  HIROSHI TAKESHIMA

  Annals of the New York Academy of Sciences, 1993, Peer-reviewed

  
• Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain

  Yasuhiro Hakamata; Junichi Nakai; Hiroshi Takeshima; Keiji Imoto

  FEBS Letters, 09 Nov. 1992, Peer-reviewed

  
• CYCLIC AMP-DEPENDENT PHOSPHORYLATION AND REGULATION OF THE CARDIAC DIHYDROPYRIDINE-SENSITIVE CA CHANNEL

  A YOSHIDA; M TAKAHASHI; S NISHIMURA; H TAKESHIMA; S KOKUBUN

  FEBS LETTERS, Sep. 1992, Peer-reviewed

  
• PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION FROM CDNA OF THE CARDIAC RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL

  J NAKAI; T IMAGAWA; Y HAKAMATA; M SHIGEKAWA; H TAKESHIMA; S NUMA

  FEBS LETTERS, Oct. 1990, Peer-reviewed

  
• MOLECULAR INSIGHTS INTO EXCITATION-CONTRACTION COUPLING

  S NUMA; T TANABE; H TAKESHIMA; A MIKAMI; T NIIDOME; S NISHIMURA; BA ADAMS; KG BEAM

  BRAIN /, 1990, Peer-reviewed

  
• FUNCTIONAL EXPRESSION OF THE CALCIUM RELEASE CHANNEL FROM SKELETAL-MUSCLE RYANODINE RECEPTOR CDNA

  R PENNER; E NEHER; H TAKESHIMA; S NISHIMURA; S NUMA

  FEBS LETTERS, Dec. 1989, Peer-reviewed

  
• PRIMARY STRUCTURE AND FUNCTIONAL EXPRESSION OF THE CARDIAC DIHYDROPYRIDINE-SENSITIVE CALCIUM-CHANNEL

  A MIKAMI; K IMOTO; T TANABE; T NIIDOME; Y MORI; H TAKESHIMA; S NARUMIYA; S NUMA

  NATURE, Jul. 1989, Peer-reviewed

  
• PRIMARY STRUCTURE AND EXPRESSION FROM COMPLEMENTARY-DNA OF SKELETAL-MUSCLE RYANODINE RECEPTOR

  H TAKESHIMA; S NISHIMURA; T MATSUMOTO; H ISHIDA; K KANGAWA; N MINAMINO; H MATSUO; M UEDA; M HANAOKA; T HIROSE; S NUMA

  NATURE, Jun. 1989, Peer-reviewed

  
• PRIMARY STRUCTURE OF THE RECEPTOR FOR CALCIUM-CHANNEL BLOCKERS FROM SKELETAL-MUSCLE

  T TANABE; H TAKESHIMA; A MIKAMI; FLOCKERZI, V; H TAKAHASHI; K KANGAWA; M KOJIMA; H MATSUO; T HIROSE; S NUMA

  NATURE, Jul. 1987, Peer-reviewed

  
• EXPRESSION OF FUNCTIONAL SODIUM-CHANNELS FROM CLONED CDNA

  M NODA; T IKEDA; H SUZUKI; H TAKESHIMA; T TAKAHASHI; M KUNO; S NUMA

  NATURE, Aug. 1986, Peer-reviewed

  
• EXISTENCE OF DISTINCT SODIUM-CHANNEL MESSENGER-RNAS IN RAT-BRAIN

  M NODA; T IKEDA; T KAYANO; H SUZUKI; H TAKESHIMA; M KURASAKI; H TAKAHASHI; S NUMA

  NATURE, Mar. 1986, Peer-reviewed

  
• INHIBITION OF LIVER ACETYL-COENZYME-A CARBOXYLASE BY 2-TETRADECANYLGLUTARATE

  H TAKESHIMA; A ENDO; K WADA; T TANABE

  JOURNAL OF ANTIBIOTICS, Feb. 1986, Peer-reviewed

  

Misc.

• 【ノシセプチンの分子薬理学】新しい疼痛制御ペプチド ノシセプチンとその受容体の発見と生理学的意義

  杉本 哲夫; 宝谷 剛志; 竹島 浩

  医学のあゆみ, Jun. 1998

  
• TRIM Family Proteins in Intracellular Vesicle Trafficking

  Kristyn Gumpper; Ki Ho Park; Mingzhai Sun; Pei-Hui Lin; Tao Tan; Miyuki Nishi; Hiroshi Takeshima; Jianjie Ma

  BIOPHYSICAL JOURNAL, Feb. 2017

  
• Electrophysiological Comparison of TRIC-A and TRIC-B, Two Trimeric Intracellular Cation Channels Associated with Intracellular Ca2+-Stores

  Samantha Jane Pitt; Ki Ho Park; Nancy Younis; Miyuki Nishi; Hiroshi Takeshima; Rebecca Sitsapesan; Jianjie Ma

  BIOPHYSICAL JOURNAL, Feb. 2009

  
• TRIC-Bチャネルの骨形成と骨芽細胞における生理機能の解析

  趙 成珠; 市村 敦彦; 山本 浩司; 竹島 浩

  日本薬学会年会要旨集, Mar. 2016

  
• Nitric Oxide-Induced Calcium Release via Ryanodine Receptors

  Toshiko Yamazawa; Sho Kakizawa; Yili Chen; Akihiro Ito; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Osamu Sato; Takashi Sakurai; Katsuji Oguchi; Hiroshi Takeshima; Nobuhito Saito; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• Nitric oxide-induced calcium release via ryanodine receptors

  Toshiko Yamazawa; Sho Kakizawa; Hideto Oyamada; Takashi Murayama; Nagomi Kurebayashi; Osamu Sato; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

  
• Involvement of Nitric oxide-induced calcium release in extinction of cerebellum-dependent motor learning

  Sho Kakizawa; Yasushi Kishimoto; Taisuke Miyazaki; Midori Tanaka; Takashi Murayama; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• 活性化した筋衛星細胞におけるMyoD依存的なGm7325遺伝子の発現

  武井大祐; 西美幸; 深田宗一朗; 土居雅夫; 岡村均; 上住聡芳; 吉田守克; 宮里幹也; 市村敦彦; 市村敦彦; 竹島浩

  日本筋学会学術集会プログラム・抄録集, 2017

  
• Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for long-term depression in the cerebellum

  S. Kakizawa; Y. Kishimoto; K. Hashimoto; T. Miyazaki; K. Furutani; H. Shimizu; M. Fukaya; M. Nishi; H. Sakagami; A. Ikeda; H. Kondo; M. Kano; M. Watanabe; M. Iino; H. Takeshima

  JOURNAL OF NEUROCHEMISTRY, Jul. 2008

  
• Intracellular Ca2+ regulation analysis in mice non-pregnant and pregnant myometrial smooth muscle cells

  Katsuhito Matsuki; Masashi Takemoto; Yoshiaki Suzuki; Susumu Ohya; Hiroshi Takeshima; Yuji Imaizumi

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• Expression and function of ryanodine receptor type 3 in nonpregnant and pregnant myometrium of the mice

  Masashi Takemoto; Hisao Yamamura; Susumu Ohya; Hiroshi Takeshima; Yuji Imaizumi

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

  
• The contribution of ryanodine receptor type 2 to E-C coupling and the regulation of resting tone in urinary bladder myocytes

  Shingo Hotta; Kozo Morimura; Susumu Ohya; Katsuhiko Muraki; Hiroshi Takeshima; Yuji Imaizumi

  ACTA PHARMACOLOGICA SINICA, Jul. 2006

  
• MG29 Interacts with Bin1 for Maintaining T-Tubule Structure in Skeletal Muscle Physiology and Regeneration

  Xinyu Zhou; Kristyn Gumpper; Xinxin Wang; Junwei Wu; Tao Tan; Miyuki Nishi; Hiroshi Takeshima; Jianjie Ma; Hua Zhu

  BIOPHYSICAL JOURNAL, Feb. 2017

  
• Zinc Binding to MG53 Facilitates Repair of Injury to Cell Membrane

  Peihui Lin; Chuanxi Cai; Hua Zhu; Jae-Kyun Ko; Moonsun Hwang; Zui Pan; Tao Tan; Daiju Yamazaki; Hiroshi Takeshima; Irina Korichneva; Jianjie Ma

  BIOPHYSICAL JOURNAL, Feb. 2016

  
• 新規カルシウム放出機構「一酸化窒素依存的カルシウム放出」と小脳依存性運動学習への関与

  柿澤昌; 岸本泰司; 宮崎太輔; 田中碧; 村山尚; 渡辺雅彦; 飯野正光; 竹島浩

  日本NO学会学術集会プログラム抄録集, 12 Jun. 2015

  
• Mitsugumin 56 is an MBOAT Family Member and Contributes to Postnatal Muscle Maturation

  Myuki Nishi; Bo Van; Shinji Komazaki; Daiju Yamazaki; Ki-Ho Park; Jianjie Ma; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Jan. 2015

  
• MG56, a Member of the MBOAT Family of Proteins, Regulates Intracellular Calcium Signaling in Striated Muscle

  Matthew Sermersheim; Xinyu Zhou; Ki Ho Park; Pei-Hui Lin; Jacob Yount; Wayne Chen; Miyuki Nishi; Hiroshi Takeshima; Jianjie Ma

  BIOPHYSICAL JOURNAL, Jan. 2015

  
• The Mboat Family Protein Mitsugumin 56 Contributes to Postnatal Maturation in the Muscle Sarcoplasmic Reticulum

  Bo Van; Miyuki Nishi; Shinji Komazaki; Ki Ho Park; Daiju Yamazaki; Jianjie Ma; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• Isoproterenol-induced cardiac fibrosis in Tric-a-knockout mice

  Daiju Yamazaki; ChengZhu Zhao; ShengChen Tao; ChaoHong Wang; Miyuki Nishi; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• H+ Inhibits TRIC-B Channels Derived from Mouse TRIC-A Knockout Tissue

  Fiona O'Brien; Elisa Venturi; Elena Galfre; Antoni Matyjaszkiewicz; Daiju Yamazaki; Miyuki Nishi; Hiroshi Takeshima; Rebecca Sitsapesan

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• TRIC-A Prevents Store-Overload Induced Calcium Release Through Interaction with the Cardiac Ryanodine Receptor

  Xinyu Zhou; Ki Ho Park; Pei-hui Lin; Mingzhai Sun; Zui Pan; Miyuki Nishi; S. R. Wayne Chen; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• Impaired Bone Formation in TRIC-B-Knockout Mice

  Chengzhu Zhao; Daiju Yamazaki; Fumiyo Aoyama; Tsunaki Iida; Miyuki Nishi; Akira Sawaguchi; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• ホスホチロシンアダプターShcB欠損マウスにおける小脳機能とプルキンエ細胞内カルシウムシグナル系の阻害

  KAKIZAWA AKIRA; KISHIMOTO YASUSHI; YAMAMOTO SHIN'ICHIRO; OGAMI KAZUKO; YASUDA KUNIHIKO; SAKAI RYUICHI; TAKESHIMA HIROSHI; MORI NOZOMU

  基礎老化研究, 12 May 2013

  
• TRIC-A regulate SR Ca2+ distribution in vascular smooth muscle cells

  Daiju Yamazaki; ShengChen Tao; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

  
• The Role of Ca2+ Handling in TRIC Knockout Neonatal Cardiomyocytes

  Chengzhu Zhao; Kiho Park; Daisuke Naitou; Chaohong Wang; Daiju Yamazaki; Miyuki Nishi; Jianjie Ma; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• Hypotension in SM-Specific TRIC-A-Transgenic Mice

  Shengchen Tao; Daiju Yamazaki; Miyuki Nishi; Jianjie Ma; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• Co-Expression of TRIC-A and Cardiac Ryanodine Receptor affects Store-Overload Induced Calcium Release in HEK293 Cells

  Xinyu Zhou; Ki Ho Park; Pei-hui Lin; Daiju Yamazaki; Zui Pan; S. R. Wayne Chen; Hiroshi Takeshima; Jianjie Ma

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• Regulation of Intracellular Calcium Store by a Phosphotyrosine Adaptor ShcB in Cerebellar Purkinje Cells

  Sho Kakizawa; Yasushi Kishimoto; Shinichiro Yamamoto; Kazuko Onga; Kunihiko Yasuda; Ryuichi Sakai; Hiroshi Takeshima; Nozomu Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

  
• Voltage-Dependent Stochastic Gating Models of TRIC-B Channels

  Antoni Matyjaszkiewicz; Elisa Venturi; Daiju Yamazaki; Miyuki Nishi; Krasimira Tsaneva-Atanasova; Hiroshi Takeshima; Rebecca Sitsapesan

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• TRIM50 Regulates Vesicular Trafficking for Acid Secretion in Gastric Parietal Cells

  Miyuki Nishi; Fumiyo Aoyama; Fumihiko Kisa; Hua Zhu; Mingzhai Sun; Peihui Lin; Bo Van; Jianjie Ma; Akira Sawaguchi; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• Nitric oxide-induced Ca2+release (NICR) mediated by ryanodine receptor 1 is essential for synaptic plasticity in the cerebellum

  Sho Kakizawa; Toshiko Yamazawa; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Masahiko Watanabe; Nozomu Mori; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Masamitsu Iino

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• TRIC-A channels regulate blood pressure in vascular smooth muscle

  Daiju Yamazaki; Satomi Kita; Miyuki Nishi; Yuji Imaizumi; Takahiro Iwamoto; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• Arrhythmic Intracellular Ca2+ Signaling and Electrocardiogram in the Heart of the TRIC-A(-/-) Mice

  Ki Ho Park; Daiju Yamazaki; Daisuke Naitou; Chengzhu Zhao; Zui Pan; Hiroshi Takeshima; Jianjie Ma

  BIOPHYSICAL JOURNAL, Jan. 2012

  
• Upregulation of Calcium Influx via Cav1.1 in Skeletal Muscle Fibers from JP-45 Calsequestrin 1 Double Knock Out Mice

  Barbara Mosca; Leda Bergamelli; Mirko Vukcevic; Susan Treves; Cecilia Paolini; Miyuki Nishi; Hiroshi Takeshima; Feliciano Protasi; Francesco Zorzato

  BIOPHYSICAL JOURNAL, Jan. 2012

  
• 一酸化窒素によるリアノジン受容体を介したCa2+放出機構

  山澤 徳志子; 柿澤 昌; 小山田 英人; 村山 尚; 呉林 なごみ; 佐藤 治; 櫻井 隆; 小口 勝司; 竹島 浩; 飯野 正光

  日本薬理学雑誌, Oct. 2011

  
• TRIC-A Channel and Blood Pressure Regulation

  Daiju Yamazaki; Satomi Kita; Shinji Komazaki; Daisuke Naitou; Miyuki Nishi; Hisao Yamamura; Yuji Imaizumi; Takahiro Iwamoto; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Feb. 2011

  
• Protein Oxidation Inhibits Nitric Oxide-Mediated Signaling Pathway Essential for Synaptic Plasticity

  Sho Kakizawa; Masahiko Shibazaki; Nozomu Mori; Hiroshi Takeshima

  BIOPHYSICAL JOURNAL, Feb. 2011

  
• リアノジン受容体を介したNOによるCa²⁺放出の機能的意義

  山澤徳志子; 柿澤昌; 柿澤昌; 陳毅力; 伊藤明博; 村山尚; 小山田英人; 呉林なごみ; 佐藤治; 櫻井隆; 小口勝司; 竹島浩; 斉藤延人; 飯野正光

  日本循環薬理学会口演要旨集, 2011

  
• Nitric oxide-induced calcium release mediated by ryanodine receptors is a novel calcium-releasing mechanism essential for synaptic plasticity in the cerebellum

  Sho Kakizawa; Toshiko Yamazawa; Takashi Murayama; Hideto Oyamada; Nagomi Kurebayashi; Masahiko Watanabe; Nozomu Mori; Katsuji Oguchi; Takashi Sakurai; Hiroshi Takeshima; Masamitsu Iino

  NEUROSCIENCE RESEARCH, 2011

  
• Knockdown of TRIC-B from tric-a(-/-) mice Alters Intracellular Ca2+ Signaling in Skeletal and Cardiac Muscles

  Ki Ho Park; Xiaoli Zhao; Daiju Yamazaki; Samantha Pitt; Andoria Tjondrokoesoemo; Shinji Komazaki; Jae-Kyun Ko; Pei-Hui Lin; Marco Brotto; Rebecca Sitsapesan; Noah Weisleder; Hiroshi Takeshima; Jianjie Ma

  BIOPHYSICAL JOURNAL, Jan. 2010

  
• Leucine-Zipper Mediated Intermolecular Interaction between MG53 is Essential for Cellular Membrane Repair

  Moonsun Hwang; Jae-Kyun Ko; Chuanxi Cai; Peihui Lin; Zui Pan; Noah Weisleder; Miyuki Nishi; Hiroshi Takeshima; Jianjie Ma

  BIOPHYSICAL JOURNAL, Jan. 2010

  
• Sarcalumenin plays a critical role in age-related cardiac dysfunction due to decreases in SERCA2a expression and activity

  Qibin Jiao; Toru Akaike; Hiroshi Takeshima; Yoshihiro Ishikawa; Susumu Minamisawa

  JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010

  
• Function of TRIC channels in the ER/SR

  Daiju Yamazaki; Miyuki Nishi; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

  
• Abnormal behavior of methamphetamine-induced sensitization is associated with impaired CaM kinase II activity in junctophilin deficient mice

  Shigeki Moriguchi; Hiroshi Takeshima; Kohji Fukunaga

  NEUROSCIENCE RESEARCH, 2010

  
• TRIC channel function in sarco/endoplasmic reticulum

  Daiju Yamazaki; Shinichiro Yamamoto; Miyuki Nishi; Hiroshi Takeshima

  JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010

  
• DEFICIENT OF MEMORY FORMATION MEDIATED BY IMPAIRMENT OF INTRACELLULAR CALCIUM HOMEOSTASIS IN NEURONAL JUNCTOPHILIN DEFICIT MICE

  S. Moriguchi; H. Takeshima; K. Fukunaga

  JOURNAL OF NEUROCHEMISTRY, Sep. 2009

  
• Functional roles of ryanodine receptor type 3 in the membrane potential regulation in vascular smooth muscle

  Daiki Kato; Hisao Yamamura; Susumu Ohya; Hiroshi Takeshima; Yuji Imaizumi

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

  
• MODULATION OF SKELETAL MUSCLE EXCITATION-CONTRACTION COUPLING BY PROTEIN COMPONENTS OF THE SARCOPLASMIC RETICULUM JUNCTIONAL FACE MEMBRANE

  Francesco Zorzato; Osvaldo Delbono; Susan Treves; Miyuki Nishi; Hiroshi Takeshima

  JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009

  
• TRIC-B channels is critical for physiological functions of alveolar epithelial cells

  Daiju Yamazaki; Shinji Komazaki; Aya Mishima; Miyuki Nishi; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009

  
• The effect of physiological stresses such as aging on cardiac function in sarcalumenin-deficient mice.

  Jiao Qibin; Shimura Miei; Akaike Toru; Takeshima Hiroshi; Ishikawa Yoshihiro; Minamisawa Susumu

  Proceedings of Annual Meeting of the Physiological Society of Japan, 2008

  
• Junctophilin-mediated functional coupling of channels essential for cerebellar synaptic plasticity

  Sho Kakizawa; Yasushi Kishimoto; Sin-ya Saito; Kouichi Hashimoto; Taisuke Miyazaki; Kazuharu Furutani; Miyuki Nishi; Hiroyuki Sakagami; Hisatake Kondo; Masanobu Kano; Masahiko Watanabe; Masamitsu Iino; Hiroshi Takeshima

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007

  
• Impairment of memory function in neural junctophilin deficient mice

  Shigeki Moriguchi; Miyuki Nishi; Hirornu Yawo; Hiroshi Takeshima; Kohji Fukunaga

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007

  
• Junctophilin ノックアウトマウス海馬における細胞内カルシウム異常と学習障害

  森口茂樹; 西美幸; 八尾寛; 竹島浩; 福永浩司

  応用薬理, 07 Aug. 2006

  
• Dysfunction of afterhyperpolarization in hippocampal neuron from neural junctophilin mutant mice

  Shigeki Moriguchi; Miyuki Nishi; Hiromu Yawo; Hiroshi Takeshima; Kohji Fukunaga

  NEUROSCIENCE RESEARCH, 2006

  
• Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells (vol 95, pg 1215, 2005)

  S Matsuya; H Sakagami; A Tohgo; Y Owada; HW Shin; H Takeshima; K Nakayama; S Kokubun; H Kondo

  JOURNAL OF NEUROCHEMISTRY, Nov. 2005

  
• Transgenic mice expressing junctophilin type 1 in cardiac myocytes.

  M Nishi; S Komazaki; H Takeshima

  BIOPHYSICAL JOURNAL, Feb. 2003

  
• In vivo pain-inhibitory role of nociceptin/orphanin FQ in the spinal cord

  M Inoue; H Takeshima; H Ueda

  BRAIN RESEARCH, Nov. 1999

  
• Molecular cloning of cDNA encoding the Drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel.

  Xu, X; MB Bhat; M Nishi; H Takeshima; J Ma

  BIOPHYSICAL JOURNAL, Jan. 1999

  
• Ion channel activity of MG29, a synaptophysin family member protein from the triad junction of skeletal muscle.

  RY Nagaraj; M Nishi; H Takeshima; J Ma

  BIOPHYSICAL JOURNAL, Jan. 1999

  
• Co-expression of ryanodine receptor and MG29 (a novel triad junction protein) in CHO cells.

  RY Nagaraj; MB Bhat; M Nishi; H Takeshima; J Ma

  BIOPHYSICAL JOURNAL, Jan. 1999

  
• Functional characterization of the Ca2+ release channels in skeletal myocyte from mice lacking type-1 ryanodine receptor

  T Yamazawa; H Takeshima; T Ikemoto; T Sakurai; M Endo; M Iino

  JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, Apr. 1996

  
• Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45

  Osvaldo Delbono; Jinyu Xia; Susan Treves; Zhong-Min Wang; Ramon Jimenez-Moreno; Anthony M. Payne; Maria Laura Messi; Alexandre Briguet; Florian Schaerer; Miyuki Nishi; Hiroshi Takeshima; Francesco Zorzato

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2007, Peer-reviewed

  
• Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins

  Shigeki Moriguchi; Miyuki Nishi; Shinji Komazaki; Hiroyuki Sakagami; Taisuke Miyazaki; Haruko Masumiya; Shin-ya Saito; Masahiko Watanabe; Hisatake Kondo; Hiromu Yawo; Kohji Fukunaga; Hiroshi Takeshima

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2006, Peer-reviewed

  
• Power spectral analysis of heart rate variability in ryanodine receptor type 3 knockout mice

  K Ju; T Kuwaki; H Takeshima; M Iino; M Kumada

  PROCEEDINGS OF THE 1997 16TH SOUTHERN BIOMEDICAL ENGINEERING CONFERENCE, 1997, Peer-reviewed

  

Presentations

• TRIC channel subtypes, willing partners with Ca2+ release channels in intracellular stores

  Gordon Research Conference: Ca2+ signaling, 27 Jun. 2011, Gordon Research Conference

  
• Immuno-proteomic approach to E-C coupling: junctophilin and TRIC channel in cardiac Ca2+ release

  IUPS Whole-day Symposium, 28 Jul. 2009, 国際生理学会

  
• TRIC channel subtypes and SR/ER Ca2+ release

  Gordon Research Conference: Muscle Excitation-Contraction Coupling, 18 Jun. 2009, Gordon Research Conference

  
• Molecular components supporting ryanodine receptor-mediated Ca2+ release: roles of junctophilin and TRIC channel in cardiac Ca2+ release

  JST Japan-Mexico Scientific Workshop, 25 Feb. 2009, JST

  

Books and Other Publications

• 基礎生命科学

  竹島浩

  京都廣川書店, 01 Apr. 2008, Not refereed

  

Works

• ノシセプチン受容体の生理機能

  From 1998

  
• Physiological functions of nociceptin receptor

  From 1998

  
• リアノジン受容体の構造と機能

  From 1994

  
• Structure-function relationship of ryanodine receptor

  From 1994

  

Awards

• 2000

  日本生化学会, 日本生化学会奨励賞

External funds: Kakenhi

• 活動量の変化に伴う骨格筋の可塑的変化のメカニズムの解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 59020:Sports sciences-related

  Osaka University of Health and Sport Sciences;National Cardiovascular Center Research Institute

  渡邊 大輝

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ミツグミン23;スキンドファイバー;骨格筋疲労;細胞内遊離Ca2+;筋小胞体;カルシウム漏出;筋疲労;不活動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03481/
• TRIC and MG23 channels in store Ca2+ handling

  Grant-in-Aid for Scientific Research (B)

  Basic Section 48020:Physiology-related

  Kyoto University

  竹島 浩

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  小胞体;Ca2+ストア;Ca2+シグナル;成長板軟骨細胞;マクロファージ;骨格筋;イオンチャネル;小胞体Ca2+放出

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02663/
• The genetic analysis and underlying function of the endoplasmic reticulum membrane protein targeting inherited arrhythmogenic syndromes

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53020:Cardiology-related

  Hiroshima University

  伊藤 英樹

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  リアノジン受容体;心室細動;突然死;シミュレーション;小胞体;リアノジン;カルシウム;特発性心室細動;筋小胞体;遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K08473/
• 心調律における細胞内小胞体カウンターイオンチャネル（TRIC）の重要性

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48020:Physiology-related

  Hirosaki University

  村上 学

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  カルシウム;イオン;マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07255/
• Study on TRIC and MG23 channels

  Grant-in-Aid for Scientific Research (B)

  Basic Section 48020:Physiology-related

  Kyoto University

  Hiroshi Takeshima

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  小胞体;Ca2+ストア;Ca2+シグナリング;Ca2+シグナル;カウンターイオン;TRICチャネル;MG23チャネル;Ca2+放出;イオンチャネル;カルシウムストア

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02597/
• Study on TRIC channel and MG56

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroshi Takeshima

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  TRICチャネル;ミツグミン56;生理学;骨芽細胞;小胞体;ＭＧ５６

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04676/
• Vesicular dynamics in parietal and muscle cells

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroshi Takeshima

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  MG53;TRIM50

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26650034/
• Counter ion movement during Ca2+ release

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroshi TAKESHIMA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  小胞体Ca2+;カウンターイオン;TRICチャネル;小胞体Ca2+放出;筋小胞体;Ca2+ストア;Ca2+取り込み;Ca2+ポンプ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24657133/
• Study of TRIC and MG23 channels

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Hiroshi TAKESHIMA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  TRICチャネル;小胞体Ca2+放出;血管平滑筋;ミツグミン２３;Ca2+スパーク;ミツグミン53;TRIM50;ミツグミン23;脂質二重膜再構成;単粒子解析;リアノジン受容体;高血圧

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23240055/
• Identification of muscular senescence-related genes

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroshi TAKESHIMA

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  サルコペニア;筋老化;筋萎縮;筋小胞体;Ca^<2+>ハンドリング;サルカルメニン;小胞体Ca2+ポンプ;加齢骨格筋;心不全;Ca2+ハンドリング;筋委縮;遺伝子発現;病態マーカー;microRNA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659066/
• Roles of novel intracellular ion channels

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Hiroshi TAKESHIMA

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  TRICチャネル;ミツグミン23;小胞体;細胞内Ca^<2+>ストア;リアノジン受容体;細胞内カルシウムストア;IP3受容体;カルミン;Ca2+放出;ミツグミン53

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20249004/
• 新規小胞体膜タンパク質CSNの構造と機能

  Grant-in-Aid for Exploratory Research

  Kyoto University;Tohoku University

  竹島 浩

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  小胞体;Ca2+放出;容量依存性Ca2+流入;Ca2+結合タンパク質;小胞体ストレス;カルシウムストア;ノックアウトマウス;膜タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17659060/
• Transportsome on biomembrane systems: its molecular assembly and physiological function.

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University;Kyorin University

  Yoshikatsu KANAI

  From 01 Apr. 2005, To 31 Mar. 2011, Project Closed

  輸送体;プロスタグランジン;傍糸球体装置;近位尿細管;レニン;膜輸送;トランスポーター;複合体;生体膜;上皮輸送;イオンチャネル;分子複合体;ポンプ;生体恒常性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17081015/
• Channel micro-assembly in junctional membrane complexes

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;Tohoku University

  Hiroshi TAKESHIMA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  ジャンクトフィリン;結合膜構造;小胞体Ca^<2+>放出;小胞体;膜修復;ミツグミン53;TRICチャネル;肺胞上皮細胞;筋ジストロフィー;RBCCファミリー;TRIMファミリー;Ca2+放出;リアノジン受容体;Ca2+結合タンパク質;神経可塑性;後科分極;カウンターイオン;後過分極;カルシウムストア;ノックアウトマウス;Ca2+チャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17081001/
• 中枢神経系におけるジャンクトフィリンの生理機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tohoku University

  竹島 浩

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  ジャンクトフィリン;結合膜構造;小胞体;Ca2+放出;Ca2+シグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16015208/
• エンドフィリン複合体のクラスリンを介するエンドサイトーシスにおける機能の解析

  Grant-in-Aid for Scientific Research (B)

  Tohoku University

  根本 康夫

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  クラスリン;エンドサイトーシス;リン脂質;rho GTPase;GAP;トランスフェリン受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15370048/
• A study on the molecular hasis of intracellular Ca^<2+> stores

  Grant-in-Aid for Scientific Research (S)

  Kyoto University;Tohoku University

  Hiroshi TAKESHIMA

  From 01 Apr. 2003, To 31 Mar. 2008, Project Closed

  Ca2+放出;小胞体;リアノジン受容体;ジャンクトフィリン;TRICチャネル;カルミン;結合膜構造;チャネル機能共役;カウンターイオン;K+チャネル;Ca2+依存性K+チャネル;神経可塑性;後過分極;カルシウムストア;興奮性細胞;筋収縮;Ca2+ストア;Ca2+結合タンパク質;ジャンクロフィリン, Ca^<2+> release;endoplasmic reticulum;junctophilin;Calumin;ryanodine receptor;TRIC channel;junctional membrane complex;channel crosstalk

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15109005/
• ミツグミン53に関する研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tohoku University

  竹島 浩

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  ミツグミン53;カリウムチャネル;心筋細胞;骨格筋細胞;細胞膜;エンドソーム;RBCCファミリー;TRIMファミリー;E3ユビキチンリガーゼ;骨格筋;心筋

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15032203/
• 3型ジャンクトフィリンとハンチントン類似病

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tohoku University

  竹島 浩

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  カルシウムシグナリング;ノックアウトマウス;シグナルシークエンストラップ法;ジャンクトフィリン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14017006/
• ノシセプチン受容体欠損マウスにおける中枢機能の補充機序

  Grant-in-Aid for Exploratory Research

  Tohoku University

  竹島 浩

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  ノシセプチン;ノックアウトマウス;疼痛調節;記憶学習;ノシセプチン受容体;ノシスタチン;神経ペプチド;疼痛伝達;鎮痛薬;聴覚調節

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13877012/
• Structure and function of ryanodine receptor

  Grant-in-Aid for Scientific Research (B)

  Tokoku University;Kurume University

  Hiroshi TAKESHIMA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  リアノジン受容体;ジャンクトフィリン;細胞内カルシウムストア;カルシウム放出;結合膜構造;Ca^<2+>ストア;興奮収縮連関;Ca^<2+>チャネル;三つ組構造, ryanodine receptor;junctophilin;intracellular calcium ions;calcium release;junctional membrane

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13470028/
• 新規受容体蛋白ファミリーの機能解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tohoku University;Kurume University

  竹島 浩

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  カルシウムシグナリング;ノックアウトマウス;シグナルシークエンストラップ法;ジャンクトフィリン;神経細胞;受容体;シグナル伝達;蛋白リン酸化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13041054/
• Molecular physiological characterization of Ca2+ signal-regulating ion channels that control vectorial substance transport

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University, Graduate School of Engineering;Okazaki National Research Institutes

  Eyasuo MORI

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  遺伝子;生理学;バイオテクノロジー;薬理学;細胞・組織;イオンチャネル;生体分子;ノックアウトマウス;上皮細胞;Ca^<2+>シグナリング;Ca^<2+>チャネル;小胞体, gene;physiology;biotechnologv;pharmaco logy;cell, tissue;ion channel

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12144210/
• 細胞内シグナルフローの可視化解析

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  The University of Tokyo

  飯野 正光

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  カルシウム;一酸化窒素;リン酸化;ミオシン;イノシトール三リン酸;イメージング;プルキンエ細胞;血管;リシ酸化;NFAT

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12002003/
• Nociceptin receptor antagonist

  Grant-in-Aid for Scientific Research (B).

  Institute of Life Science, Kurume University;The University of Tokyo

  Hiroshi TAKESHIMA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  ノシセプチン;ノシセプチン受容体;オピオイドペプチド;オピオイド受容体, nociceptin;nociceptin receptor;opioids;opioid receptors

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11559005/
• Molecular contraction of Ca^<2+> signaling

  Grant-in-Aid for Scientific Research (B).

  Institute of Life Science, Kurume University;The University of Tokyo

  Hiroshi TAKESHIMA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  リアノジン受容体;Ca^<2+>放出チャネル;興奮収縮連関;ジヒドロピリジン受容体;Ca^<2+>シグナリング;Ca^2^+放出チャネル;Ca^2^+シグナリング, ryanodine receptor;Ca^<2+> release channel;Excitation-contraction coupling;fihydropyridina receptor;Ca^<2+> sigualing

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11470022/
• 新規神経ペプチドの検索と単離

  Grant-in-Aid for Exploratory Research

  The University of Tokyo

  竹島 浩

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  神経ペプチド;ノシセプチン;ノシセプチン受容体;オルファン受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10877015/
• 記憶学習とオピオイド耐性における可塑性へのノシセプチン系の関与

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  竹島 浩

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  ノシセプチン;ノシセプチン受容体;疼痛;長期増強;記憶学習;オピオイド耐性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10156210/
• ノシセプチン受容体による記憶学習および長期増強の調節

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  竹島 浩

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  ノシセプチン;ノシセプチン受容体;記憶学習;長期増強;疼痛;ノックアウトマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10155206/
• Structure and function of ryanodine receptors

  Grant-in-Aid for Scientific Research (B)

  The University of Tokyo

  Hiroshi TAKESHIMA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  リアノジン;リアノジン受容体;Ca^<2+> 放出チャネル;三つ組構造;ノックアウトマウス;筋収縮;Ca^<2+>放出チャネル;カルシウム放出チャネル;カルシウム・ストア;カフェイン, Ca^<2+> release channel;ryanodine receptor;intracellular Ca^<2+>;caffeine;muscle contraction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470022/
• リマノジンタイプ3受容体欠損マウスの体温および自律神経調節機能の研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Chiba University

  桑木 共之

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  リアノジン受容体;ノックアウトマウス;心拍変動;パワースペクトル;最大エントロピー法;心筋細胞;心臓交感神経;心臓副交感神経

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09259207/
• オピオイド受容体相同物(ROR-C,MOR-C)の中枢神経系における機能

  Grant-in-Aid for Exploratory Research

  The University of Tokyo

  竹島 浩

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  オピオイド受容体;ノシセプチン;ノシセプチン受容体;疼痛反応;聴覚調節

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08877021/
• Functional analysis of ryanodine receptor using molecular genetic technique

  Grant-in-Aid for Scientific Research (B)

  University of Tokyo

  Hiroshi TAKESHIMA

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  カルシウム放出チャネル;リアノジン受容体;細胞内カルシウム;カフェイン;筋収縮, ryanodine receptor;intracellular Ca^<2+>;Ca^<2+> release channel;muscle contraction;caffeine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457025/
• 興奮収縮連関機構の構造機能協関

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  飯野 正光

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  骨格筋;心筋;カルシウム;リアノジン受容体;画像解析;蛍光カルシウム指示薬;興奮収縮連関

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08268212/
• Functions of the two types of calcium release channels in the sarcoplasmic reticulum of skeletal muscle.

  Grant-in-Aid for Scientific Research (B)

  Saitama Medical School

  Makoto ENDO

  From 01 Apr. 1995, To 31 Mar. 1997, Project Closed

  カルシウム放出チャネル;リアノジン受容体(1型);リアノジン受容体(3型);Ca^<2+>によるCa^<2+>放出(CICR);筋小胞体;骨格筋;興奮収縮連関;カルモデュリン;CaによるCa放出(CICR);リアノジン受容体(骨格筋型);リアノジン受容体(脳型);筋拘縮, calcium release channel;type 1 ryanodine receptor;type 3 ryanodine receptor;Ca-induced Ca release (CICR);sarcoplasmic reticulum;skeletal muscle;excitation-contraction coupling (EC coupling);calmodulin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457023/
• オピオイド受容体分子のジーンターゲッティングによる生理機能解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Saitama Medical University

  竹島 浩

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  オピオイドペプチド;モルヒネ;鎖 ノシセプチン;G蛋白カップル受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07278240/
• 骨格筋小胞体カルシウム放出チャネルとカルシウムポンプの機能協関

  Grant-in-Aid for Scientific Research on Priority Areas

  Saitama Medical University

  遠藤 實

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  カルシウム放出チャネル;リアノジン受容体;カルモジュリン;CaによるCa放出(CICR);筋小胞体;スキンド・ファイバー;骨格筋型,脳型リアノジン受容体;リアノジン受容体欠損マウス(dyspedic mouse)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07276234/
• Molecular biological studies of ryanodine receptor/calcium release channel

  Grant-in-Aid for General Scientific Research (B)

  Saitama Medical School

  Hiroshi TAKESHIMA

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  カルシウム放出チャンネル;細胞内カルシウム;リアノジン;筋収縮;カフェイン, calcium release channel;intracellular calcium;ryanodine;muscle contraction;caffeine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454150/
• リアノジン受容体/カルシウム放出チャンネル遺伝子欠失マウスの作製と解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Tokyo Institute of Psychiatry

  竹島 美幸

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  リアノジン受容体;カルシウム放出チャンネル;筋収縮;ジーンターゲッティング;カルシウムイオン;分子生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06268214/
• Studies on the structure and function of neurotransmitter receptors and ionic channels

  Grant-in-Aid for Specially Promoted Research

  Kyoto University

  Shosaku NUMA

  From 01 Apr. 1988, To 31 Mar. 1992, Project Closed

  ニコチン性アセチルコリン受容体;Na^+チャンネル;Ca^<2+>チャンネル;Ca^<2+>放出チャンネル;ムスカリン性アセチルコリン受容体;cDNA発現;静位特異的変異;興奮収縮連関;部位特異的変異;グルタミン酸受容体;Ca^<2+> releaseチャンネル;cGMP-gatedチャンネル;K^+チャンネル;電位感受機構;パッチクランプ法;E-C coupling;ムスカリン性アセチルコリン受容体サブタイプ, Nicotinic acetylcholine receptor;Na^+ channel;Ca^<2+> channel;Ca^<2+> release channel;Muscarinic acetylcholine receptor;cDNA expression;Site-directed mutagenesis;Excitation-contraction coupling

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63065003/
• TRPP3チャネルによる心筋・交感神経情報伝達系(cAMP系)への影響

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48020:Physiology-related

  Hirosaki University

  村上 学

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  腎臓;多発性嚢胞腎;TRPP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06342/
• 活動量の変化に伴う骨格筋の可塑的変化のメカニズムの解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 59020:Sports sciences-related

  Osaka University of Health and Sport Sciences;National Cardiovascular Center Research Institute

  渡邊 大輝

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ミツグミン23;スキンドファイバー;骨格筋疲労;細胞内遊離Ca2+;筋小胞体;カルシウム漏出;筋疲労;不活動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24738/

External funds: others

• ミツグミン53の生理機能と筋疾患

  平成21年度病態代謝研究会

  From 2009
• TRICチャネルの生理機能

  平成21年度ノバルティス科学振興財団

  From 2009
• TRICチャネルに関する研究

  平成21年度倉田記念日立科学技術財団

  From 2009
• 高血圧におけるTRICチャネルの役割

  平成22年度病態代謝研究会

  From 2010
• 本態性高血圧とTRICチャネル

  平成22年度財団法人慢性疾患・リハビリテイション研究振興財団

  From 2010
• 小胞体TRICチャネルと循環機能

  平成22年度武田科学振興財団

  From 2010
• TRICチャネル欠損高血圧における食塩感受性

  平成22年度ソルトサイエンス研究財団

  From 2010
• TRICチャネルと不整脈

  平成22年度三共生命科学研究振興財団

  From 2010
• 胃特異的ユビキチンリガーゼTRIM50に関する研究

  平成24年度日本応用酵素協会

  From 2012

  竹島浩
• 胃特異的ユビキチンリガーゼTRIM50に関する研究

  平成24年度日本応用酵素協会

  From Apr. 2012
• 筋特異的MBOATファミリー分子MG56に関する研究

  平成25年度小野医学研究財団　

  From 2013

  竹島浩
• 創薬ケミカルバイオロジーの国際共同研究ネットワーク （平成26年度分）

  研究拠点形成事業　A.先端拠点形成型

  From 01 Apr. 2014, To 31 Mar. 2015

  竹島　浩
• 創薬ケミカルバイオロジーの国際共同研究ネットワーク （平成27年度分）

  研究拠点形成事業　A.先端拠点形成型

  From 01 Apr. 2015, To 31 Mar. 2016

  竹島　浩
• 創薬ケミカルバイオロジーの国際共同研究ネットワーク （平成28年度分）

  研究拠点形成事業　A.先端拠点形成型

  From 01 Apr. 2016, To 31 Mar. 2017

  竹島　浩
• 心筋における MG53 と TRIC チャネルの機能 （2019年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2019, To 31 Mar. 2020

  竹島 浩
• 心筋における MG53 と TRIC チャネルの機能 （2020年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2020, To 31 Mar. 2021

  竹島 浩

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Biomedical Sciences

  U130, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Biological Chemistry)

  D137, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Sciences III

  6007, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Biological Chemistry

  1207, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Biomedical Sciences

  U130, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Biochemistry A

  8205, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Biological Chemistry)

  D137, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Biological Chemistry)

  B807, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Biological Chemistry)

  E807, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Biological Chemistry)

  8137, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Biological Chemistry I

  1213, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences III

  6007, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Clinical Pharmacy

  6001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Biological Chemistry)

  8137, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Biological Chemistry)

  D137, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Biological Chemistry)

  B807, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Biomedical Sciences

  U130, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• 薬学生物学、生物化学
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  doctoral program

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  doctoral program

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Fundamental Biology for Pharmaceutical Sciences

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Advanced Pharmaceutical Sciences III

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Outline of Physiological Chemistry

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Biomedical Sciences

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Biological Chemistry)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Pharmaceutical Sciences III

  Spring, 薬学研究科

Participation in PhD Defense

• Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

  LIU FENG, Graduate School of Pharmaceutical Sciences, Chief Examiner

  25 Mar. 2024
• 肝臓特異的Ccdc47欠損マウスの作出と小胞体ストレス誘導剤ツニカマイシンに対する応答の検討

  NAKAJIMA NOBUHISA, Graduate School of Pharmaceutical Sciences, Chief Examiner

  25 Mar. 2024
• 臨床ビッグデータ解析と薬理学的実験の統合による腱障害予防法の探索

  FURUTA HARUKA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• Regulation of the orphan receptor Gpr176 activity via post-translational modifications in the central circadian clock

  WANG TIANYU, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• A drug repurposing study based on clinical big data for the protective role of vitamin D in olanzapine-induced dyslipidemia

  ZHOU ZIJIAN, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• 血管性認知障害におけるグリア細胞の病態生理学的役割の解明

  KAKAE MASASHI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• オリゴデンドロサイト前駆細胞の制御機構および病態時の機能に関する研究

  OHASHI KANA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• Mechanism of thermal entrainment of the circadian clock by newly identified post-transcriptional regulation

  INOUE YUICHI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• C-type natriuretic peptide facilitates autonomous Ca2+ entry in growth plate chondrocytes for stimulating bone growth （C型ナトリウム利尿ペプチドは自発的なCa2+流入を介して骨伸長を促進する）

  MIYAZAKI YUU, Graduate School of Pharmaceutical Sciences, Chief Examiner

  23 Mar. 2022
• Regulation of Siesta by the Central Circadian Clock in the Brain and its Physiological Role in Memory Consolidation

  MAEKAWA YOTA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• 情動行動を司る背側縫線核セロトニン神経の役割に関する研究

  NAGAI YUMA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• 臨床ビッグデータ解析と薬理学的実証を用いたドパミンD2受容体遮断薬誘発多動性障害抑制法の創出

  NAGAOKA KOKI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• 報酬および疼痛制御を担う神経機構に関する研究

  KAWAI HIROYUKI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• 慢性疼痛に関与するLPA合成酵素の役割とその阻害薬探索に関する研究

  TANAKA KEIGO, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022

Administration

School management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  総合博物館　協議員
• From 01 Apr. 2023, To 31 Mar. 2025

  総合博物館　運営委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2024

  障害者入試委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2025

  教育制度委員会ＦＤ専門委員会 委員
• From 01 Apr. 2023, To 31 Mar. 2025

  教育制度委員会 委員
• From 01 Jan. 2022, To 31 Dec. 2023

  オープンキャンパス委員会 委員
• From 01 Apr. 2008, To 31 Mar. 2010

  国際教育プログラム委員会 委員
• From 01 Feb. 2009, To 31 Mar. 2010

  放射性同位元素等管理委員会 委員
• From 01 Apr. 2009, To 31 Mar. 2011

  組換えDNA実験安全委員会 委員
• From 01 Oct. 2010, To 31 Mar. 2011

  企画委員会 委員
• From 01 Oct. 2010, To 31 Mar. 2011

  大学評価委員会 委員
• From 01 Apr. 2008, To 31 Mar. 2011

  基礎教育専門委員会 委員
• From 01 Oct. 2010, To 30 Sep. 2012

  理事補
• From 15 Dec. 2009, To 30 Sep. 2010

  総長室特命補佐
• From 01 Apr. 2011, To 31 Mar. 2013

  企画委員会 委員
• From 01 Apr. 2011, To 31 Mar. 2013

  大学評価委員会 委員
• From 01 Apr. 2011, To 31 Mar. 2013

  戦略定員検討委員会 委員
• From 01 Apr. 2011, To 31 Mar. 2013

  拡大役員懇談会
• From 01 Apr. 2012, To 31 Mar. 2013

  大学評価小委員会 委員長
• From 01 Oct. 2010, To 31 Mar. 2015

  大学評価小委員会 委員
• From 01 Oct. 2014, To 30 Sep. 2016

  企画委員会 委員
• From 01 Jan. 2011, To 31 Mar. 2012

  教育活動評価委員会　委員
• From 20 Nov. 2012, To 31 Mar. 2013

  教育活動評価ワーキンググループ　委員
• From 01 Nov. 2012, To 31 Mar. 2013

  教育活動評価委員会　委員
• From 20 Nov. 2012, To 31 Mar. 2013

  教員活動評価ワーキンググループ 委員
• From 01 Jan. 2011, To 31 Mar. 2012

  教員活動評価委員会 委員
• From 01 Nov. 2012, To 31 Mar. 2013

  教員活動評価委員会 委員
• From 01 Jan. 2017, To 31 Dec. 2017

  オープンキャンパス委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2018

  障害者入試委員会 委員
• From 01 May 2016, To 31 Mar. 2019

  国際高等教育院 企画評価専門委員会 生物学部会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  教育研究評議会 評議員
• From 01 Apr. 2021, To 31 Mar. 2023

  教育研究評議会 評議員

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  実験動物施設運営委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  情報システム委員会
• From 01 Apr. 2024, To 31 Mar. 2025

  環境・安全衛生委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  図書委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  教務委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  将来計画委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2025

  動物実験委員会　委員長
• From 01 Apr. 2022, To 31 Mar. 2024

  学術情報メディアセンター　協議員会　協議員
• From 01 Apr. 2011, To 31 Mar. 2014

  寄附講座「システム創薬科学講座」運営委員　委員
• From 01 Apr. 2011, To 31 Mar. 2014

  革新的ナノバイオ創薬研究拠点運営委員会　委員
• From 01 Apr. 2012, To 31 Mar. 2013

  最先端創薬研究センター運営委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2012

  情報システム委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2025

  建物・設備・機器管理運営委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2021

  人権委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  ハラスメント相談窓口
• From 01 Apr. 2019, To 31 Mar. 2023

  産学協同講座・寄附講座検討委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2023

  将来計画委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2023

  予算委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2023

  自己評価等調査検討委員会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  学生委員
• From 01 Apr. 2021, To 31 Mar. 2022

  就職委員
• From 01 Apr. 2021, To 31 Mar. 2022

  学生委員　委員長