Non-physiologic interaction of MG53 with insulin receptor and lack of evidence for MG53’s role in controlling insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues
Kyung Eun Lee; Miyuki Nishi; Jongsoo Kim; Takashi Murayama; Zachary Dawson; Xiaoliang Wang; Xinyu Zhou; Tao Tan; Chuanxi Cai; Hiroshi Takeshima; Ki Ho Park
2024年01月30日
The biophysical properties of TRIC-A and TRIC-B and their interactions with RyR2
Extraocular muscle function is impaired in ryr3(-/-) mice
Jan Eckhardt; Christoph Bachmann; Marijana Sekukc-Jablanovic; Volker Enzmann; Ki Ho Park; Jianjie Ma; Hiroshi Takeshima; Francesco Zorzato; Susan Treves
SERCA2aの発現および活性の低下による老化関連心機能障害においてsarcalumeninは重要な役割をもつ(Sarcalumenin Plays a Critical Role in Age-related Cardiac Dysfunction due to Decreases in SERCA2a Expression and Activity)
筋小胞体内カルシウム結合蛋白質sarcalumenin欠損マウスの心機能に与える加齢などの生理学的ストレスの影響(The effect of physiological stresses such as aging on cardiac function in sarcalumenin-deficient mice)
TRIC-A Channel Maintains Store Calcium Handling by Interacting With Type 2 Ryanodine Receptor in Cardiac Muscle
Zhou Xinyu; Ki Ho Park; Daiju Yamazaki; Lin Pei-hui; Miyuki Nishi; Ma Zhiwei; Qiu Liming; Takashi Murayama; Zou Xiaoqin; Hiroshi Takeshima; Zhou Jingsong; Ma Jianjie
CIRCULATION RESEARCH, 2020年02月
Calcium phosphate mineralization in bone tissues directly observed in aqueous liquid by atmospheric SEM (ASEM) without staining: microfluidics crystallization chamber and immuno-EM.
Dysregulated Zn2+ homeostasis impairs cardiac type-2 ryanodine receptor and mitsugumin 23 functions, leading to sarcoplasmic reticulum Ca2+ leakage
Benedict Reilly-O'Donnell; Gavin B. Robertson; Angela Karumbi; Connor McIntyre; Wojciech Bal; Miyuki Nishi; Hiroshi Takeshima; Alan J. Stewart; Samantha J. Pitt
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017年08月, 査読有り
Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A
Sam El-Ajouz; Elisa Venturi; Katja Witschas; Matthew Beech; Abigail D. Wilson; Chris Lindsay; David Eberhardt; Fiona O'Brien; Tsunaki Iida; Miyuki Nishi; Hiroshi Takeshima; Rebecca Sitsapesan
JOURNAL OF PHYSIOLOGY-LONDON, 2017年07月, 査読有り
病理学 TRIC-B遺伝子変異による骨形成不全症
市村 敦彦; 趙 成珠; 竹島 浩
医学のあゆみ, 2017年02月, 査読有り
Gm7325 is MyoD-dependently expressed in activated muscle satellite cells.
Barbara Mosca; Osvaldo Delbono; Maria Laura Messi; Leda Bergamelli; Zhong-Min Wang; Mirko Vukcevic; Ruben Lopez; Susan Treves; Miyuki Nishi; Hiroshi Takeshima; Cecilia Paolini; Marta Martini; Giorgio Rispoli; Feliciano Protasi; Francesco Zorzato
NATURE COMMUNICATIONS, 2013年02月, 査読有り
TRIC channels supporting efficient Ca2+ release from intracellular stores
Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging
Osvaldo Delbono; Maria Laura Messi; Zhong-Min Wang; Susan Treves; Barbara Mosca; Leda Bergamelli; Miyuki Nishi; Hiroshi Takeshima; Hang Shi; Bingzhong Xue; Francesco Zorzato
EXPERIMENTAL GERONTOLOGY, 2012年04月, 査読有り
Loss of junctophilin-3 contributes to huntington disease-like 2 pathogenesis
Ana I. Seixas; Susan E. Holmes; Hiroshi Takeshima; Amira Pavlovich; Nancy Sachs; Jennifer L. Pruitt; Isabel Silveira; Christopher A. Ross; Russell L. Margolis; Dobrila D. Rudnicki
ANNALS OF NEUROLOGY, 2012年02月, 査読有り
Loss of junctophilin-3 contributes to huntington disease-like 2 pathogenesis
Ana I. Seixas; Susan E. Holmes; Hiroshi Takeshima; Amira Pavlovich; Nancy Sachs; Jennifer L. Pruitt; Isabel Silveira; Christopher A. Ross; Russell L. Margolis; Dobrila D. Rudnicki
ANNALS OF NEUROLOGY, 2012年02月, 査読有り
Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function
Comprehensive behavioral phenotyping of ryanodine receptor type 3 (RyR3) knockout mice: decreased social contact duration in two social interaction tests
Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP
Richard Stewart; Lele Song; Simon M. Carter; Charalambos Sigalas; Nathan R. Zaccai; Venkateswarlu Kanamarlapudi; Manjunatha B. Bhat; Hiroshi Takeshima; Rebecca Sitsapesan
JOURNAL OF MEMBRANE BIOLOGY, 2008年03月, 査読有り
Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK
A. Tara Huddleston; Wei Tang; Hiroshi Takeshima; Susan L. Hamilton; Eric Klann
JOURNAL OF NEUROPHYSIOLOGY, 2008年03月, 査読有り
Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice
Circadian-dependent learning and memory enhancement in nociceptin receptor-deficient mice with a novel KUROBOX apparatus using stress-free positive cue task
Jun Nagai; Mamoru Kurokawa; Hiroshi Takeshima; Brigitte L. Kieffer; Hiroshi Ueda
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2007年04月, 査読有り
Conformation-dependent stability of junctophilin 1 (JP1) and ryanodine receptor type 1 (RyRl) channel complex is mediated by their hyper-reactive thiols
Andrew J. Phimister; Jozsef Lango; Eun Hui Lee; Michael A. Ernst-Russell; Hiroshi Takeshima; Jianjie Ma; Paul D. Allen; Isaac N. Pessah
JOURNAL OF BIOLOGICAL CHEMISTRY, 2007年03月, 査読有り
ORL1 receptor-mediated down-regulation of mPER2 in the suprachiasmatic nucleus accelerates re-entrainment of the circadian clock following a shift in the environmental light/dark cycle
Uncoupling store-operated Ca2+ entry and altered Ca2+ release from sarcoplasmic reticulum through silencing of junctophilin genes
Y Hirata; M Brotto; N Weisleder; Y Chu; PH Lin; XL Zhao; A Thornton; S Komazaki; H Takeshima; JJ Ma; Z Pan
BIOPHYSICAL JOURNAL, 2006年06月, 査読有り
Impaired cerebellar functions in mutant mice lacking DNER
A Tohgo; M Eiraku; T Miyazaki; E Miura; S Kawaguchi; M Nishi; M Watanabe; T Hirano; M Kengaku; H Takeshima
MOLECULAR AND CELLULAR NEUROSCIENCE, 2006年02月, 査読有り
The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E-2-induced allodynia, tactile pain associated with nerve injury
E Okuda-Ashitaka; T Minami; S Matsumura; H Takeshima; RK Reinscheid; O Civelli; S Ito
EUROPEAN JOURNAL OF NEUROSCIENCE, 2006年02月, 査読有り
DNER as key molecule for cerebellar maturation
Shin-Ya Saito; Hiroshi Takeshima
CEREBELLUM, 2006年, 査読有り
Erratum: Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells (Journal of Neurochemistry (2005) 93 (674-85))
Enhanced hippocampal acetylcholine release in nociceptin-receptor knockout mice
K Uezu; A Sano; H Sei; K Toida; T Houtani; T Sugimoto; T Suzuki-Yamamoto; H Takeshima; K Ishimura; Y Morita
BRAIN RESEARCH, 2005年07月, 査読有り
Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation
FA Taverna; J Georgiou; RJ McDonald; NS Hong; A Kraev; MW Salter; H Takeshima; RU Muller; JC Roder
JOURNAL OF PHYSIOLOGY-LONDON, 2005年06月, 査読有り
Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells
S Matsuya; H Sakagami; A Tohgo; Y Owada; HW Shin; H Takeshima; K Nakayama; S Kokubun; H Kondo
JOURNAL OF NEUROCHEMISTRY, 2005年05月, 査読有り
Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice
M Yoshida; S Minamisawa; M Shimura; S Komazaki; H Kume; M Zhang; K Matsumura; M Nishi; M Saito; Y Saeki; Y Ishikawa; T Yanagisawa; H Takeshima
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005年02月, 査読有り
Methamphetamine sensitization in nociceptin receptor knockout mice: locomotor and c-fos expression
C Okabe; H Takeshima; NP Murphy
EUROPEAN JOURNAL OF PHARMACOLOGY, 2005年01月, 査読有り
Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies
S Minamisawa; J Oshikawa; H Takeshima; M Hoshijima; YB Wang; KR Chien; Y Ishikawa; R Matsuoka
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004年12月, 査読有り
Defective maintenance of intracellular Ca2+ homeostasis is linked to increased muscle fatigability in the MG29 null mice
MAP Brotto; RY Nagaraj; LS Brotto; H Takeshima; JJ Ma; TM Nosek
CELL RESEARCH, 2004年10月, 査読有り
Intradermal nociceptin elicits itch-associated responses through leukotriene B-4 in mice
T Andoh; Y Yageta; H Takeshima; Y Kuraishi
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004年07月, 査読有り
Co-expression of MG29 and ryanodine receptor leads to apoptotic cell death - Effect mediated by intracellular Ca2+ release
Z Pan; Y Hirata; RY Nagaraj; JY Zhao; M Nishi; SM Hayek; MB Bhat; H Takeshima; JJ Ma
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004年05月, 査読有り
Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis
T Sakakibara; Y Nemoto; T Nukiwa; H Takeshima
FEBS LETTERS, 2004年05月, 査読有り
Exogenous, but not endogenous nociceptin modulates mesolimbic dopamine release in mice
M Koizumi; N Midorikawa; H Takeshima; NP Murphy
JOURNAL OF NEUROCHEMISTRY, 2004年04月, 査読有り
Lack of nociceptin receptor alters body temperature during resting period in mice
K Uezu; H Sei; A Sano; K Toida; T Suzuki-Yamamoto; T Houtani; T Sugimoto; H Takeshima; K Ishimura; Y Morita
NEUROREPORT, 2004年04月, 査読有り
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
K Lutfy; S Eitan; CD Bryant; YC Yang; N Saliminejad; W Walwyn; BL Kieffer; H Takeshima; FI Carroll; NT Maidment; CJ Evans
JOURNAL OF NEUROSCIENCE, 2003年11月, 査読有り
Changes in Ca2+ handling in adult MG29-deficient skeletal muscle
N Kurebayashi; H Takeshima; M Nishi; T Murayama; E Suzuki; Y Ogawa
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003年10月, 査読有り
Coexpression of junctophilin type 3 and type 4 in brain
M Nishi; H Sakagami; S Komazaki; H Kondo; H Takeshima
MOLECULAR BRAIN RESEARCH, 2003年10月, 査読有り
Normal sensitivity to acute pain, but increased inflammatory hyperalgesia in mice lacking the nociceptin precursor polypeptide or the nociceptin receptor
UB Depner; RK Reinscheid; H Takeshima; K Brune; HU Zeilhofer
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003年06月, 査読有り
Abnormal junctional membrane structures in cardiac myocytes expressing ectopic junctophilin type 1
S Komazaki; M Nishi; H Takeshima
FEBS LETTERS, 2003年05月, 査読有り
In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord
M Inoue; T Kawashima; H Takeshima; G Calo; A Inoue; Y Nakata; H Ueda
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003年05月, 査読有り
A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene
T Houtani; M Ikeda; M Kase; K Sato; S Sakuma; S Kakimoto; T Ueyama; Y Munemoto; H Takeshima; T Sugimoto
NEUROSCIENCE LETTERS, 2003年01月, 査読有り
Ryanodine receptor and junctional membrane structure
Hiroshi Takeshima
Folia Pharmacologica Japonica, 2003年, 査読有り
Delta/Notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like ReDeat-cont ining protein T ryeted to dendrites of developing and adult central nervous system neurons
M Eiraku; Y Hirata; H Takeshima; T Hirano; M Kengaku
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002年07月, 査読有り
Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1
S Komazaki; K Ito; H Takeshima; H Nakamura
FEBS LETTERS, 2002年07月, 査読有り
Dysfunction of store-operated calcium channel in muscle cells lacking mg29
Z Pan; DM Yang; RY Nararaj; TA Nosek; M Nishi; H Takeshima; HP Cheng; JJ Ma
NATURE CELL BIOLOGY, 2002年05月, 査読有り
Essential immunoregulatory role for BCAP in B cell development and function
T Yamazaki; K Takeda; K Gotoh; H Takeshima; S Akira; T Kurosaki
JOURNAL OF EXPERIMENTAL MEDICINE, 2002年03月, 査読有り
A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory
GA Higgins; JNC Kew; JG Richards; H Takeshima; F Jenck; G Adam; J Wichmann; JA Kemp; AJ Grottick
EUROPEAN JOURNAL OF NEUROSCIENCE, 2002年03月, 査読有り
Motor discoordination in mutant mice lacking junctophilin type 3
M Nishi; K Hashimoto; K Kuriyama; S Komazaki; M Kano; S Shibata; H Takeshima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2002年03月, 査読有り
Store-operated Ca2+ entry uncoupled with ryanodine receptor and junctional membrane complex in heart muscle cells
A Uehara; M Yasukochi; Imanaga, I; M Nishi; H Takeshima
CELL CALCIUM, 2002年02月, 査読有り
Intracellular Ca2+ store in embryonic cardiac myocytes
H Takeshima
FRONTIERS IN BIOSCIENCE, 2002年07月, 査読有り
Abnormal formation of sarcoplasmic reticulum networks and triads during early development of skeletal muscle cells in mitsugumin29-deficient mice
S Komazaki; M Nishi; H Takeshima; H Nakamura
DEVELOPMENT GROWTH & DIFFERENTIATION, 2001年12月, 査読有り
Important role of junctophilin in nematode motor function
M Yoshida; A Sugimoto; Y Ohshima; H Takeshima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001年11月, 査読有り
Brainstem auditory regions in mice: expression of nociceptin/orphanin FQ precursor mRNA in select neurons
S Kakimoto; T Houtani; K Sato; T Ueyama; S Sakuma; Y Munemoto; H Ohishi; M Kase; T Yamashita; H Takeshima; T Sugimoto
DM Yang; Z Pan; H Takeshima; CH Wu; RY Nagaraj; JJ Ma; HP Cheng
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001年10月, 査読有り
Pronociceptive effects of nociceptin/orphanin FQ (13-17) at peripheral and spinal level in mice
M Inoue; S Matsunaga; MH Rashid; A Yoshida; K Mizuno; T Sakurada; H Takeshima; H Ueda
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2001年10月, 査読有り
Deficiency of triad junction and contraction in mutant skeletal muscle lacking junctophilin type 1
K Ito; S Komazaki; K Sasamoto; M Yoshida; M Nishi; K Kitamura; H Takeshima
JOURNAL OF CELL BIOLOGY, 2001年09月, 査読有り
Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function
GA Higgins; AJ Grottick; TM Ballard; JG Richards; J Messer; H Takeshima; M Pauly-Evers; F Jenck; G Adam; J Wichmann
NEUROPHARMACOLOGY, 2001年07月, 査読有り
In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated [S-35]GTP gamma S binding to mouse brain
D Ichikawa; S Ozaki; T Azuma; H Nambu; H Kawamoto; Y Iwasawa; H Takeshima; H Ohta
NEUROREPORT, 2001年06月, 査読有り
Postsynaptic modulation of AMPA receptor-mediated synaptic responses and LTP by the type 3 ryanodine receptor
M Shimuta; M Yoshikawa; M Fukaya; M Watanabe; H Takeshima; T Manabe
MOLECULAR AND CELLULAR NEUROSCIENCE, 2001年05月, 査読有り
Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor
S Ahmadi; C Kotalla; H Guhring; H Takeshima; A Pahl; HU Zeilhofer
MOLECULAR PHARMACOLOGY, 2001年03月, 査読有り
Ryanodine receptors and intracellular Ca2+ stores
H Takeshima
SEIKAGAKU, 2001年01月, 査読有り
Morphine tolerance and dependence in the nociceptin receptor knockout mice
T Mamiya; Y Noda; Ren, X; T Nagai; H Takeshima; M Ukai; T Nabeshima
JOURNAL OF NEURAL TRANSMISSION, 2001年, 査読有り
Increased susceptibility to fatigue of slow- and fast-twitch muscles from mice lacking the MG29 gene
RY Nagaraj; CM Nosek; MAP Brotto; M Nishi; H Takeshima; TM Nosek; JJ Ma
PHYSIOLOGICAL GENOMICS, 2000年11月, 査読有り
Characterization of a calcium-regulation domain of the skeletal-muscle ryanodine receptor
SM Hayek; XS Zhu; MB Bhat; JY Zhao; H Takeshima; HH Valdivia; JJ Ma
BIOCHEMICAL JOURNAL, 2000年10月, 査読有り
A region of the sulfonylurea receptor critical for a modulation of ATP-sensitive K+ channels by G-protein beta gamma-subunits
Y Wada; T Yamashita; K Imai; R Miura; K Takao; M Nishi; H Takeshima; T Asano; R Morishita; K Nishizawa; S Kokubun; T Nukada
EMBO JOURNAL, 2000年09月, 査読有り
Distribution of nociceptin/orphanin FQ precursor protein and receptor in brain and spinal cord: A study using in situ hybridization and X-gal histochemistry in receptor-deficient mice
T Houtani; M Nishi; H Takeshima; K Sato; S Sakuma; S Kakimoto; T Ueyama; T Noda; T Sugimoto
JOURNAL OF COMPARATIVE NEUROLOGY, 2000年08月, 査読有り
Characterization of human junctophilin subtype genes
M Nishi; A Mizushima; K Nakagawara; H Takeshima
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000年07月, 査読有り
Role of nociceptin systems in learning and memory
Y Noda; T Mamiya; T Manabe; M Nishi; H Takeshima; T Nabeshima
PEPTIDES, 2000年07月, 査読有り
Junctophilins: A novel family of junctional membrane complex proteins
H Takeshima; S Komazaki; M Nishi; M Lino; K Kangawa
MOLECULAR CELL, 2000年07月, 査読有り
Comparison of Ca2+ sparks produced independently by two ryanodine receptor isoforms (type 1 or type 3)
MW Conklin; CA Ahern; P Vallejo; Sorrentino, V; H Takeshima; R Coronado
BIOPHYSICAL JOURNAL, 2000年04月, 査読有り
Mutant mice lacking ryanodine receptor type 3 exhibit deficits of contextual fear conditioning and activation of calcium/calmodulin-dependent protein kinase II in the hippocampus
Y Kouzu; T Moriya; H Takeshima; T Yoshioka; S Shibata
MOLECULAR BRAIN RESEARCH, 2000年03月, 査読有り
Molecular cloning of cDNA encoding a Drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel
XH Xu; MB Bhat; M Nishi; H Takeshima; JJ Ma
BIOPHYSICAL JOURNAL, 2000年03月, 査読有り
Abnormal features in skeletal muscle from mice lacking mitsugumin29
M Nishi; S Komazaki; N Kurebayashi; Y Ogawa; T Noda; M Iino; H Takeshima
JOURNAL OF CELL BIOLOGY, 1999年12月, 査読有り
Involvement of ryanodine receptor type 3 in dopamine release from the striatum: Evidence from mutant mice lacking this receptor
K Wan; T Moriya; M Akiyama; H Takeshima; S Shibata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999年12月, 査読有り
A negatively charged region of the skeletal muscle ryanodine receptor is involved in Ca2+-dependent regulation of the Ca2+ release channel
SM Hayek; JY Zhao; M Bhat; XH Xu; R Nagaraj; Z Pan; H Takeshima; JJ Ma
FEBS LETTERS, 1999年11月, 査読有り
Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord
M Inoue; Shimohira, I; A Yoshida; A Zimmer; H Takeshima; T Sakurada; H Ueda
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1999年10月, 査読有り
Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers
BE Flucher; A Conti; H Takeshima; Sorrentino, V
JOURNAL OF CELL BIOLOGY, 1999年08月, 査読有り
Expression and functional characterization of the cardiac muscle ryanodine receptor Ca2+ release channel in Chinese hamster ovary cells
MB Bhat; SM Hayek; JY Zhao; WJ Zang; H Takeshima; WG Wier; JJ Ma
BIOPHYSICAL JOURNAL, 1999年08月, 査読有り
Immunolocalization of mitsugumin29 in developing skeletal muscle and effects of the protein expressed in amphibian embryonic cells
S Komazaki; M Nishi; K Kangawa; H Takeshima
DEVELOPMENTAL DYNAMICS, 1999年06月, 査読有り
Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns
K Hirose; S Kadowaki; M Tanabe; H Takeshima; M Iino
SCIENCE, 1999年05月, 査読有り
Fluorescent indicators for inositol 1,4,5-trisphosphate based on bioconjugates of pleckstrin homology domain and fluorescent dyes
K Hirose; H Takeshima; M Iino
ANALYTICAL COMMUNICATIONS, 1999年05月, 査読有り
Nociceptin system plays a role in the memory retention: involvement of naloxone benzoylhydrazone binding sites
T Mamiya; Y Noda; M Nishi; H Takeshima; T Nabeshima
NEUROREPORT, 1999年04月, 査読有り
RhoN, a novel small GTP-binding protein expressed predominantly in neurons and hepatic stellate cells
M Nishi; H Takeshima; T Houtani; K Nakagawara; T Noda; T Sugimoto
MOLECULAR BRAIN RESEARCH, 1999年04月, 査読有り
Contractile function is unaltered in diaphragm from mice lacking calcium release channel isoform 3
JS Clancy; H Takeshima; SL Hamilton; MB Reid
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1999年10月, 査読有り
Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3
T Ikemoto; H Takeshima; M Iino; M Endo
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1998年12月, 査読有り
Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors
S Komazaki; T Ikemoto; H Takeshima; M Iino; M Endo; H Nakamura
CELL AND TISSUE RESEARCH, 1998年12月, 査読有り
Facilitation of long-term potentiation and memory in mice lacking nociception receptors
T Manabe; Y Noda; T Mamiya; H Katagiri; T Houtani; M Nishi; T Noda; T Takahashi; T Sugimoto; T Nabeshima; H Takeshima
NATURE, 1998年08月, 査読有り
Mitsugumin23, a novel transmembrane protein on endoplasmic reticulum and nuclear membranes
M Nishi; S Komazaki; M Iino; K Kangawa; H Takeshima
FEBS LETTERS, 1998年08月, 査読有り
Structure and expression of mitsugumin29 gene
M Shimuta; S Komazaki; M Nishi; M Iino; K Nakagawara; H Takeshima
FEBS LETTERS, 1998年07月, 査読有り
Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice
Y Noda; T Mamiya; T Nabeshima; M Nishi; M Higashioka; H Takeshima
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998年07月, 査読有り
Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2
H Takeshima; S Komazaki; K Hirose; M Nishi; T Noda; M Lino
EMBO JOURNAL, 1998年06月, 査読有り
Mitsugumin29, a novel synaptophysin family member from the triad junction in skeletal muscle
H Takeshima; M Shimuta; S Komazaki; K Ohmi; M Nishi; M Iino; A Miyata; K Kangawa
BIOCHEMICAL JOURNAL, 1998年04月, 査読有り
Enhancement of spatial attention in nociceptin orphanin FQ receptor knockout mice
T Mamiya; Y Noda; M Nishi; H Takeshima; T Nabeshima
BRAIN RESEARCH, 1998年02月, 査読有り
Nociceptin and nociceptin receptor
M Nishi; H Takeshima
SEIKAGAKU, 1998年07月, 査読有り
Caffeine-induced release of intracellular Ca2+ from Chinese hamster ovary cells expressing skeletal muscle ryanodine receptor - Effects on full-length and carboxyl-terminal portion of Ca2+ release channels
B Manjunatha; JY Zhao; WJ Zang; CW Balke; H Takeshima; WG Wier; JJ Ma
JOURNAL OF GENERAL PHYSIOLOGY, 1997年12月, 査読有り
Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene
H Ueda; T Yamaguchi; S Tokuyama; M Inoue; M Nishi; H Takeshima
NEUROSCIENCE LETTERS, 1997年11月, 査読有り
Deletion of amino acids 1641-2437 from the foot region of skeletal muscle ryanodine receptor alters the conduction properties of the Ca release channel
MB Bhat; JY Zhao; S Hayek; EC Freeman; H Takeshima; JJ Ma
BIOPHYSICAL JOURNAL, 1997年09月, 査読有り
Functional calcium release channel formed by the carboxyl-terminal portion of ryanodine receptor
MB Bhat; JY Zhao; H Takeshima; JJ Ma
BIOPHYSICAL JOURNAL, 1997年09月, 査読有り
Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 And type 3 ryanodine receptors
T Ikemoto; S Komazaki; H Takeshima; M Nishi; T Noda; M Iino; M Endo
JOURNAL OF PHYSIOLOGY-LONDON, 1997年06月, 査読有り
Ca2+-induced Ca2+ release in Chinese hamster ovary (CHO) cells co-expressing dihydropyridine and ryanodine receptors
N Suda; D Franzius; A Fleig; S Nishimura; M Bodding; M Hoth; H Takeshima; R Penner
JOURNAL OF GENERAL PHYSIOLOGY, 1997年05月, 査読有り
Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
M Nishi; T Houtani; Y Noda; T Mamiya; K Sato; T Doi; J Kuno; H Takeshima; T Nukada; T Nabeshima; T Yamashita; T Noda; T Sugimoto
EMBO JOURNAL, 1997年04月, 査読有り
A region of the ryanodine receptor critical for excitation-contraction coupling in skeletal muscle
Identification and characterization of an endogenous ligand for opioid receptor homologue ROR-C: Its involvement in allodynic response to innocuous stimulus
E OkudaAshitaka; S Tachibana; T Houtani; T Minami; Y Masu; M Nishi; H Takeshima; T Sugimoto; S Ito
MOLECULAR BRAIN RESEARCH, 1996年12月, 査読有り
Subtype specificity of the ryanodine receptor for Ca2+ signal amplification in excitation-contraction coupling
T Yamazawa; H Takeshima; T Sakurai; M Endo; M Iino
EMBO JOURNAL, 1996年11月, 査読有り
Absence of Ca2+ current facilitation in skeletal muscle of transgenic mice lacking the type 1 ryanodine receptor
A Fleig; H Takeshima; R Penner
JOURNAL OF PHYSIOLOGY-LONDON, 1996年10月, 査読有り
Generation and characterization of mutant mice lacking ryanodine receptor type 3
H Takeshima; T Ikemoto; M Nishi; N Nishiyama; M Shimuta; Y Sugitani; J Kuno; Saito, I; H Saito; M Endo; M Iino; T Noda
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996年08月, 査読有り
Structure and regional distribution of nociceptin/orphanin FQ precursor
T Houtani; M Nishi; H Takeshima; T Nukada; T Sugimoto
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996年02月, 査読有り
OPIOID MU-RECEPTOR AND KAPPA-RECEPTOR MEDIATE PHOSPHOLIPASE-C ACTIVATION THROUGH GI1 IN XENOPUS OOCYTES
H UEDA; T MIYAMAE; N FUKUSHIMA; H TAKESHIMA; K FUKUDA; Y SASAKI; Y MISU
MOLECULAR BRAIN RESEARCH, 1995年08月, 査読有り
CA2+-INDUCED CA2+ RELEASE IN MYOCYTES FROM DYSPEDIC MICE LACKING THE TYPE-1 RYANODINE RECEPTOR
H TAKESHIMA; T YAMAZAWA; T IKEMOTO; H TAKEKURA; M NISHI; T NODA; M LINO
EMBO JOURNAL, 1995年07月, 査読有り
APPROACH TO THE ROLE OF RYANODINE RECEPTORS USING MICE WITH A TARGETED MUTATION
H TAKESHIMA
SEIKAGAKU, 1995年04月, 査読有り
STRUCTURE AND CHROMOSOMAL MAPPING OF GENES FOR THE MOUSE KAPPA-OPIOID RECEPTOR AND AN OPIOID RECEPTOR HOMOLOG (MOR-C)
M NISHI; H TAKESHIMA; M MORI; K NAKAGAWARA; T TAKEUCHI
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994年12月, 査読有り
MULTIPLE TYPES OF RYANODINE RECEPTOR CA2+ RELEASE CHANNELS ARE DIFFERENTIALLY EXPRESSED IN RABBIT BRAIN
T FURUICHI; D FURUTAMA; Y HAKAMATA; J NAKAI; H TAKESHIMA; K MIKOSHIBA
JOURNAL OF NEUROSCIENCE, 1994年08月, 査読有り
MU-OPIOID RECEPTOR - EXPRESSION AND VAGOTOMY-INDUCED DEPLETION OF THE MESSENGER-RNA IN MEDULLARY PREGANGLIONIC NEURONS
T HOUTANI; T UEYAMA; H TAKESHIMA; S KATO; K FUKUDA; K MORI; T SUGIMOTO
MOLECULAR BRAIN RESEARCH, 1994年07月, 査読有り
EXCITATION-CONTRACTION UNCOUPLING AND MUSCULAR DEGENERATION IN MICE LACKING FUNCTIONAL SKELETAL-MUSCLE RYANODINE-RECEPTOR GENE
H TAKESHIMA; M IINO; H TAKEKURA; M NISHI; J KUNO; O MINOWA; H TAKANO; T NODA
NATURE, 1994年06月, 査読有り
ISOLATION AND CHARACTERIZATION OF A GENE FOR A RYANODINE RECEPTOR CALCIUM-RELEASE CHANNEL IN DROSOPHILA-MELANOGASTER
H TAKESHIMA; M NISHI; N IWABE; T MIYATA; T HOSOYA; MASAI, I; Y HOTTA
FEBS LETTERS, 1994年01月, 査読有り
CDNA CLONING AND PHARMACOLOGICAL CHARACTERIZATION OF AN OPIOID RECEPTOR WITH HIGH AFFINITIES FOR KAPPA-SUBTYPE-SELECTIVE LIGANDS
M NISHI; H TAKESHIMA; K FUKUDA; S KATO; K MORI
FEBS LETTERS, 1993年09月, 査読有り
PRIMARY STRUCTURES AND EXPRESSION FROM CDNAS OF RAT OPIOID RECEPTOR DELTA-SUBTYPES AND MU-SUBTYPES
K FUKUDA; S KATO; K MORI; M NISHI; H TAKESHIMA
FEBS LETTERS, 1993年08月, 査読有り
REQUIREMENT OF THE CALCIUM-CHANNEL BETA-SUBUNIT FOR FUNCTIONAL CONFORMATION
S NISHIMURA; H TAKESHIMA; F HOFMANN; FLOCKERZI, V; K IMOTO
FEBS LETTERS, 1993年06月, 査読有り
A BRAIN-SPECIFIC TRANSCRIPT FROM THE 3'-TERMINAL REGION OF THE SKELETAL-MUSCLE RYANODINE RECEPTOR GENE
H TAKESHIMA; S NISHIMURA; M NISHI; M IKEDA; T SUGIMOTO
FEBS LETTERS, 1993年05月, 査読有り
Primary Structure and Expression from cDNAs of the Ryanodine Receptor
HIROSHI TAKESHIMA
Annals of the New York Academy of Sciences, 1993年, 査読有り
Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain
Junctophilin-mediated functional crosstalk between ryanodine receptors and SK channels essential for long-term depression in the cerebellum
S. Kakizawa; Y. Kishimoto; K. Hashimoto; T. Miyazaki; K. Furutani; H. Shimizu; M. Fukaya; M. Nishi; H. Sakagami; A. Ikeda; H. Kondo; M. Kano; M. Watanabe; M. Iino; H. Takeshima
JOURNAL OF NEUROCHEMISTRY, 2008年07月
Intracellular Ca2+ regulation analysis in mice non-pregnant and pregnant myometrial smooth muscle cells
Nitric oxide-induced calcium release mediated by ryanodine receptors is a novel calcium-releasing mechanism essential for synaptic plasticity in the cerebellum
Cellular and subcellular localization of EFA6C, a third member of the EFA6 family, in adult mouse Purkinje cells (vol 95, pg 1215, 2005)
S Matsuya; H Sakagami; A Tohgo; Y Owada; HW Shin; H Takeshima; K Nakayama; S Kokubun; H Kondo
JOURNAL OF NEUROCHEMISTRY, 2005年11月
Transgenic mice expressing junctophilin type 1 in cardiac myocytes.
M Nishi; S Komazaki; H Takeshima
BIOPHYSICAL JOURNAL, 2003年02月
In vivo pain-inhibitory role of nociceptin/orphanin FQ in the spinal cord
M Inoue; H Takeshima; H Ueda
BRAIN RESEARCH, 1999年11月
Molecular cloning of cDNA encoding the Drosophila ryanodine receptor and functional studies of the carboxyl-terminal calcium release channel.
Xu, X; MB Bhat; M Nishi; H Takeshima; J Ma
BIOPHYSICAL JOURNAL, 1999年01月
Ion channel activity of MG29, a synaptophysin family member protein from the triad junction of skeletal muscle.
RY Nagaraj; M Nishi; H Takeshima; J Ma
BIOPHYSICAL JOURNAL, 1999年01月
Co-expression of ryanodine receptor and MG29 (a novel triad junction protein) in CHO cells.
RY Nagaraj; MB Bhat; M Nishi; H Takeshima; J Ma
BIOPHYSICAL JOURNAL, 1999年01月
Functional characterization of the Ca2+ release channels in skeletal myocyte from mice lacking type-1 ryanodine receptor
T Yamazawa; H Takeshima; T Ikemoto; T Sakurai; M Endo; M Iino
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY, 1996年04月
Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45
Osvaldo Delbono; Jinyu Xia; Susan Treves; Zhong-Min Wang; Ramon Jimenez-Moreno; Anthony M. Payne; Maria Laura Messi; Alexandre Briguet; Florian Schaerer; Miyuki Nishi; Hiroshi Takeshima; Francesco Zorzato
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007年12月, 査読有り
Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins
Chronopharmacological manipulation of Ang II-regulatable cell autonomous oscillators in adrenal zona glomerulosa cells(副腎アルドステロン産生細胞におけるアンジオテンシンII応答性時計振動体の時間薬理学的制御)
大谷 知寛, 薬学研究科, 副査
2025年03月24日
感覚機能の制御における末梢・中枢神経細胞TRPチャネルの役割に関する研究
戸堀 翔太, 薬学研究科, 副査
2025年03月24日
Tissue-Endogenous Intracrine Steroid Hormone Deactivation Machinery in the Meibomian Gland(眼瞼マイボーム腺組織内因性イントラクラインホルモン不活性化機構の同定)
Nguyen Pham Khanh Tien, 薬学研究科, 副査
2025年03月24日
Translation-Mediated Regulatory Mechanisms Regulating Light- and Temperature-Dependent Circadian Gene Expression(転写を伴わない翻訳制御を介した光・温度による時計遺伝子発現調節機構)
SHAO XINYAN, 薬学研究科, 副査
2025年03月24日
Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages(可溶性エポキシドヒドロラーゼは腹膜マクロファージの自己分泌シグナル伝達と関連した定常状態の脂質代謝回転を維持する)
LIU FENG, 薬学研究科, 主査
2024年03月25日
肝臓特異的Ccdc47欠損マウスの作出と小胞体ストレス誘導剤ツニカマイシンに対する応答の検討
中嶋 将久, 薬学研究科, 主査
2024年03月25日
臨床ビッグデータ解析と薬理学的実験の統合による腱障害予防法の探索
古田 晴香, 薬学研究科, 副査
2023年03月23日
Regulation of the orphan receptor Gpr176 activity via post-translational modifications in the central circadian clock(概日時計中枢における翻訳後修飾を介したオーファン受容体Gpr176の活性調節)
王 甜宇, 薬学研究科, 副査
2023年03月23日
A drug repurposing study based on clinical big data for the protective role of vitamin D in olanzapine-induced dyslipidemia(臨床ビッグデータに基づくオランザピン誘発脂質異常症に対するビタミンDの予防作用の解明)
ZHOU ZIJIAN, 薬学研究科, 副査
2023年03月23日
血管性認知障害におけるグリア細胞の病態生理学的役割の解明
抱 将史, 薬学研究科, 副査
2023年03月23日
オリゴデンドロサイト前駆細胞の制御機構および病態時の機能に関する研究
大橋 佳奈, 薬学研究科, 副査
2023年03月23日
Mechanism of thermal entrainment of the circadian clock by newly identified post-transcriptional regulation (新規転写後調節機構による体内時計の温度サイクルへの位相適応メカニズム)
井ノ上 雄一, 薬学研究科, 副査
2022年03月23日
C-type natriuretic peptide facilitates autonomous Ca2+ entry in growth plate chondrocytes for stimulating bone growth (C型ナトリウム利尿ペプチドは自発的なCa2+流入を介して骨伸長を促進する)
宮﨑 侑, 薬学研究科, 主査
2022年03月23日
Regulation of Siesta by the Central Circadian Clock in the Brain and its Physiological Role in Memory Consolidation (脳内中枢時計による昼寝の制御機構とその記憶形成における役割)