Basic Information

Professional Memberships

• THE JAPANESE RADIATION RESEARCH SOCIETY
• 日本癌学会
• 日本分子生物学会

Academic Degree

• 博士（医学）(岡山大学)

High School

• High School

  広島大学附属福山高等学校

Profile

• Profile

  I graduated from a medical school and trained for ~10 years as a physician. Then I started a carrier as a molecular biologist and joined a lab in the US (Dr. Tomohiro Kurosaki). After I returned to Japan I moved to Kyoto University (Dr. Shunichi Takeda) and since then I have been in the field of DNA repair, damage response and homologous recombination. I would like to elucidate disease mechanisms in cancer and hereditary disorders.

ID,URL

• J-Global ID

  200901028335486862

Website(s) (URL(s))

• http://www.rbc.kyoto-u.ac.jp/late-effect

researchmap URL

• https://researchmap.jp/read0062989

Research

Research Topics, Overview of the research

• Research Topics

  My lab focuses on the mechanisms of self-protective DNA damage signaling elicited by exogenous (e.g. radiation) and endogenous (caused by cell metabolism) genome damage.

• Overview of the research

  I am interested in human disorders such as chromosome instability disorders, cancer, and late effects of radiation. The current topic is as follows:
  
  1. Pathogenesis of Fanconi anemia and familial breast cancer
  2. Stabilization mechanisms of the non-coding DNA regions including the common fragile sites
  3. Identification of novel genes involved in Fanconi anemia and related disorders
  4. Replication stress caused by oncogene activation
  5. Cellular response toward single or a few double strand breaks in the genome

Research Interests

• Replication stress
• genome stability
• radiation biology
• DNA repair
• Hereditary Breast and Ovarian Cancer
• Fanconi anemia
• 免疫細胞におけるシグナルトランスダクション
• 相同組換え
• Signal transduction in immune cells
• Homologons DNA recombination

Research Areas

• Life sciences, Genomics
• Life sciences, Medical biochemistry
• Environmental science/Agricultural science, Environmental effects of chemicals
• Environmental science/Agricultural science, Environmental effects of radiation
• Life sciences, Immunology
• Life sciences, Pathobiochemistry

Papers

• Genetic Profile of Myeloid Neoplasms Developed with Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome

  Mayu Morishita; Miharu Yabe; Nobuyuki Kakiuchi; Minoru Takata; Kotoe Katayama; Seiya Imoto; Seishi Ogawa; Hiromasa Yabe; Kenichi Yoshida

  Blood, 28 Nov. 2023

  
• RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination.

  Shojiro Inano; Koichi Sato; Yoko Katsuki; Wataru Kobayashi; Hiroki Tanaka; Kazuhiro Nakajima; Shinichiro Nakada; Hiroyuki Miyoshi; Kerstin Knies; Akifumi Takaori-Kondo; Detlev Schindler; Masamichi Ishiai; Hitoshi Kurumizaka; Minoru Takata

  Molecular cell, 02 Apr. 2020

  
• がんにおける染色体・ゲノム不安定性の分子基盤 相同組換えにおけるRPAおよびRAD51の動体制御はRFWD3によるユビキチン化に依存する

  稲野 将二郎; 佐藤 浩一; 勝木 陽子; 石合 正道; 中田 慎一郎; 胡桃坂 仁志; 高田 穣

  日本癌学会総会記事, Oct. 2016

  
• 放射線・ゲノムストレスに対抗する多彩な生命システムの解明に向けて E3リガーゼRFWD3は相同組換えにおいてRPAとRAD51活動を促進する重要な構成分子である(An E3 ligase RFWD3 is a critical component that facilitates RPA and RAD51 dynamics in homologous recombination)

  稲野 将二郎; 佐藤 浩一; 勝木 陽子; 中田 慎一郎; 石合 正道; 胡桃坂 仁志; 高田 穣

  日本放射線影響学会大会講演要旨集, Oct. 2016

  
• The role of SLFN11 in DNA replication stress response and its implications for the Fanconi anemia pathway

  Anfeng Mu; Yusuke Okamoto; Yoko Katsuki; Minoru Takata

  DNA Repair, Jul. 2024

  
• Erratum: Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients (Haematologica (2019) (1967) DOI: 10.3324/haematol.2018.207241)

  Minako Mori; Asuka Hira; Kenichi Yoshida; Hideki Muramatsu; Yusuke Okuno; Yuichi Shiraishi; Michiko Anmae; Jun Yasuda; Shu Tadaka; Kengo Kinoshita; Tomoo Osumi; Yasushi Noguchi; Souichi Adachi; Ryoji Kobayashi; Hiroshi Kawabata; Kohsuke Imai; Tomohiro Morio; Kazuo Tamura; Akifumi Takaori-Kondo; Masayuki Yamamoto; Satoru Miyano; Seiji Kojima; Etsuro Ito; Seishi Ogawa; Keitaro Matsuo; Hiromasa Yabe; Miharu Yabe; Minoru Takata

  Haematologica, 2020

  
• A new regulatory mechanism of homologous recombination unveiled by discovery of the new Fanconi Anemia gene, RFWD3/ FANCW

  Shojiro Inano; Minoru Takata

  Seikagaku, 2018

  
• 211 難治性喘息患者における塩酸オザグレル(OKY-046)のリンパ球と好中球に及ぼす影響について

  金広 有彦; 古藤 直紀; 岡野 智治; 菅野 尚; 武田 勝行; 高田 穣; 宗田 良; 多田 慎也; 高橋 清; 木村 郁郎

  アレルギー, 1991

  
• 224 喘息患者におけるカンジダ抗原刺激による末梢血単核球 (PBMC) 由来の好塩基球遊走活性 (BCA) に関する検討

  谷本 安; 河田 典子; 金広 有彦; 小栗栖 和郎; 高田 穣; 荒木 雅史; 松岡 孝; 宗田 良; 多田 慎也; 高橋 清; 木村 郁郎; 谷崎 勝朗

  アレルギー, 1991

  
• 269 気管支喘息患者末梢血のリンパ球及び顆粒球に及ぼす各種漢方薬の影響

  江田 良輔; 金広 有彦; 小塚 明子; 高田 穣; 清水 一紀; 宗田 良; 多田 慎也; 高橋 清; 木村 郁郎; 谷崎 勝朗

  アレルギー, 1990

  
• 74 気管支喘息の発症機序におけるInterleukin-2receptorの関与について

  小塚 明子; 木村 五郎; 山県 浩一; 金広 有彦; 江田 良輔; 難波 康夫; 高田 穰; 宗田 良; 多田 慎也; 高橋 清; 木村 郁郎

  アレルギー, 1990

  
• Mouse Slfn8 and Slfn9 genes complement human cells lacking SLFN11 during the replication stress response

  Erin Alvi; Ayako L. Mochizuki; Yoko Katsuki; Minori Ogawa; Fei Qi; Yusuke Okamoto; Minoru Takata; Anfeng Mu

  Communications Biology, 13 Oct. 2023, Peer-reviewed

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• 変異型EGFR発現非小細胞肺癌細胞株のRas12V導入によるgefitinib耐性化

  内田 亜希子; 平野 世紀; 北尾 洋之; 頼 冠名; 荻野 敦子; 豊岡 伸一; 瀧川 奈義夫; 田端 雅弘; 高田 穣; 木浦 勝行; 谷本 光音

  日本癌学会総会記事, Sep. 2006

  
• DNA損傷応答研究の最先端:分子機構、蛋白質物性から微小環境まで DNAクロスリンク修復因子SLX4のユビキチン化による制御機構

  勝木 陽子; 安倍 昌子; 中田 慎一郎; 鐘巻 将人; 矢部 みはる; 矢部 普正; 高田 穣

  日本放射線影響学会大会講演要旨集, Nov. 2018

  
• Effects of the major formaldehyde catalyzer ADH5 on phenotypes of fanconi anemia zebrafish model

  Anfeng Mu; Zimu Cao; Denggao Huang; Hiroshi Hosokawa; Shingo Maegawa; Minoru Takata

  Molecular Biology Reports, 24 Aug. 2023

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• Mitotic cells can repair DNA double-strand breaks via a homology-directed pathway.

  Yuki Sakamoto; Tetsuya Kokuta; Ai Teshigahara; Kenta Iijima; Hiroyuki Kitao; Minoru Takata; Hiroshi Tauchi

  Journal of radiation research, 01 Jan. 2021

  
• Global phosphorylation and ubiquitination dynamics in DNA-damage response network

  Adachi Jun; Narumi Ryohei; Sano Shozo; Kuga Takahisa; Shiromizu Takashi; Matsumoto Masaki; Nakayama Kei-ichi; Ikura Masae; Ikura Tsuyoshi; Takata Minoru; ??? Takeshi

  Abstracts for Annual Meeting of Japanese Proteomics Society, 2011

  
• Current topics in DNA double-strand break repair

  Junya Kobayashi; Kuniyoshi Iwabuchi; Kiyoshi Miyagawa; Eiichiro Sonoda; Keiji Suzuki; Minoru Takata; Hiroshi Tauchi

  JOURNAL OF RADIATION RESEARCH, Mar. 2008, Peer-reviewed

  
• EFFECTS OF A SPECIFIC THROMBOXANE A_2 SYNTHETASE INHIBITOR ON LYMPHOCYTE AND NEUTROPHIL FUNCTIONS IN ADULT INTRACTABLE ASTHMATICS

  Kanehiro Arihiko; Takahashi Kiyoshi; Soda Ryo; Takata Minoru; Takeda Katsuyuki; Sugano Hisashi; Yamagata Kouichi; Katagi Yukie; Kimura Ikuro

  Japanese Journal of Allergology, 1992

  
• Fanconi Anemia and Aldehyde Degradation Deficiency Syndrome: metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA Damage

  Anfeng Mu; Asuka Hira; Minako Mori; Yusuke Okamoto; Minoru Takata

  DNA Repair, Aug. 2023, Peer-reviewed, Invited, Last author, Corresponding author

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• The ribonuclease domain function is dispensable for SLFN11 to mediate cell fate decision during replication stress response

  Fei Qi; Erin Alvi; Minori Ogawa; Junya Kobayashi; Anfeng Mu; Minoru Takata

  Genes to Cells, 19 Jul. 2023, Peer-reviewed, Last author, Corresponding author

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• RFWD3 and translesion DNA polymerases contribute to PCNA modification-dependent DNA damage tolerance.

  Rie Kanao; Hidehiko Kawai; Toshiyasu Taniguchi; Minoru Takata; Chikahide Masutani

  Life science alliance, Dec. 2022, Peer-reviewed

  
• Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1 /2‐mutation carriers

  Tomoharu Mori; Yusuke Okamoto; Anfeng Mu; Yoshimi Ide; Akiyo Yoshimura; Noriko Senda; Yukiko Inagaki‐Kawata; Masahiro Kawashima; Hiroyuki Kitao; Eriko Tokunaga; Yasuo Miyoshi; Shozo Ohsumi; Koichiro Tsugawa; Tomohiko Ohta; Toyomasa Katagiri; Shigeru Ohtsuru; Kaoru Koike; Seishi Ogawa; Masakazu Toi; Hiroji Iwata; Seigo Nakamura; Keitaro Matsuo; Minoru Takata

  Cancer Medicine, 07 Nov. 2022, Peer-reviewed, Last author, Corresponding author

  
• DNA double-strand break end resection: a critical relay point for determining the pathway of repair and signaling

  Yoko Katsuki; Penny A. Jeggo; Yuki Uchihara; Minoru Takata; Atsushi Shibata

  Genome Instability & Disease, Jul. 2020, Peer-reviewed

  
• Third Report on Chicken Genes and Chromosomes 2015

  Michael Schmid; Jacqueline Smith; David W. Burt; Bronwen L. Aken; Parker B. Antin; Alan L. Archibald; Chris Ashwell; Perry J. Blackshear; Clarissa Boschiero; C. Titus Brown; Shane C. Burgess; Hans H. Cheng; William Chow; Derrick J. Coble; Amanda Cooksey; Richard P. M. A. Crooijmans; Joana Damas; Richard V. N. Davis; Dirk-Jan de Koning; Mary E. Delany; Thomas Derrien; Takele T. Desta; Ian C. Dunn; Matthew Dunn; Hans Ellegren; Lel Eoery; Ionas Erb; Marta Farre; Mario Fasold; Damarius Fleming; Paul Flicek; Katie E. Fowler; Laure Fresard; David P. Froman; Valerie Garceau; Paul P. Gardner; Almas A. Gheyas; Darren K. Griffin; Martien A. M. Groenen; Thomas Haaf; Olivier Hanotte; Alan Hart; Julien Haesler; S. Blair Hedges; Jana Hertel; Kerstin Howe; Allen Hubbard; David A. Hume; Pete Kaiser; Darek Kedra; Stephen J. Kemp; Christophe Klopp; Kalmia E. Kniel; Richard Kuo; Sandrine Lagarrigue; Susan J. Lamont; Denis M. Larkin; Raman A. Lawal; Sarah M. Markland; Fiona McCarthy; Heather A. McCormack; Marla C. McPherson; Akira Motegi; Stefan A. Muljo; Andrea Muensterberg; Rishi Nag; Indrajit Nanda; Michael Neuberger; Anne Nitsche; Cedric Notredame; Harry Noyes; Rebecca O'Connor; Elizabeth A. O'Hare; Andrew J. Oler; Sheila C. Ommeh; Helio Pais; Michael Persia; Frederique Pitel; Likit Preeyanon; Pablo Prieto Barja; Elizabeth M. Pritchett; Douglas D. Rhoads; Charmaine M. Robinson; Michael N. Romanov; Max Rothschild; Pierre-Francois Roux; Carl J. Schmidt; Alisa-Sophia Schneider; Matthew G. Schwartz; Steve M. Searle; Michael A. Skinner; Craig A. Smith; Peter F. Stadler; Tammy E. Steeves; Claus Steinlein; Liang Sun; Minoru Takata; Igor Ulitsky; Qing Wang; Ying Wang; Wesley C. Warren; Jonathan M. D. Wood; David Wragg; Huaijun Zhou

  CYTOGENETIC AND GENOME RESEARCH, 2015, Peer-reviewed

  
• 活性化EGFR変異を保有するトランスジェニックマウスにおける肺発癌に与えるvandetanibの作用(Effect of vandetanib on lung tumorigenesis in transgenic mice carrying activating EGFR mutation)

  Osawa Masahiro; Ohashi Kadoaki; Takata Saburou; Fujiwara Yoshiro; Takigawa Nagio; Tabata Masahiro; Whitsett Jeffrey; Takata Minoru; Tanimoto Mitsune; Kiura Katsuyuki

  日本呼吸器学会雑誌, May 2008

  
• PTEN欠失肺癌細胞株におけるPARP阻害剤とシスプラチンの相乗効果

  南 大輔; 瀧川 奈義夫; 武田 洋正; 高田 穣; 市原 英基; 久本 晃子; 堀田 勝幸; 田端 雅弘; 谷本 光音; 木浦 勝行

  肺癌, Oct. 2012

  
• PTEN遺伝子欠損を持つ肺癌におけるオラパリブとシスプラチンの相乗効果について(Synergistic effect of olaparib with combination of cisplatin on PTEN deficient lung tumor)

  南 大輔; 瀧川 奈義夫; 武田 洋正; 高田 穣; 市原 英基; 久本 晃子; 堀田 勝幸; 田端 雅弘; 谷本 光音; 木浦 勝行

  日本癌学会総会記事, Aug. 2012

  
• RNF168 E3 ligase participates in ubiquitin signaling and recruitment of SLX4 during DNA crosslink repair

  Yoko Katsuki; Masako Abe; Seon Young Park; Wenwen Wu; Hiromasa Yabe; Miharu Yabe; Haico van Attikum; Shinichiro Nakada; Tomohiko Ohta; Michael M. Seidman; Yonghwan Kim; Minoru Takata

  Cell Reports, Oct. 2021, Peer-reviewed, Last author, Corresponding author

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• Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress.

  Xinlin Xu; Yixi Xu; Ruiyuan Guo; Ran Xu; Congcong Fu; Mengtan Xing; Hiroyuki Sasanuma; Qing Li; Minoru Takata; Shunichi Takeda; Rong Guo; Dongyi Xu

  Nature structural & molecular biology, Jun. 2021, Peer-reviewed

  
• Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.

  Anfeng Mu; Asuka Hira; Akira Niwa; Mitsujiro Osawa; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Kazuko Inoue; Keita Kondo; Masato T Kanemaki; Tomonari Matsuda; Etsuro Ito; Seiji Kojima; Tatsutoshi Nakahata; Seishi Ogawa; Keigo Tanaka; Keitaro Matsuo; Megumu K Saito; Minoru Takata

  Blood, 15 Apr. 2021, Peer-reviewed, Last author, Corresponding author

  
• SLFN11 promotes stalled fork degradation that underlies the phenotype in Fanconi anemia cells.

  Yusuke Okamoto; Masako Abe; Anfeng Mu; Yasuko Tempaku; Colette B Rogers; Ayako L Mochizuki; Yoko Katsuki; Masato T Kanemaki; Akifumi Takaori-Kondo; Alexandra Sobeck; Anja-Katrin Bielinsky; Minoru Takata

  Blood, 21 Jan. 2021, Peer-reviewed, Last author, Corresponding author

  
• [Aldehyde degradation deficiency (ADD) syndrome: discovery of a novel fanconi anemia-like inherited BMF syndrome due to combined ADH5/ALDH2 deficiency].

  Anfeng Mu; Asuka Hira; Keitaro Matsuo; Minoru Takata

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2021

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• Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

  Felix A Dingler; Meng Wang; Anfeng Mu; Christopher L Millington; Nina Oberbeck; Sam Watcham; Lucas B Pontel; Ashley N Kamimae-Lanning; Frederic Langevin; Camille Nadler; Rebecca L Cordell; Paul S Monks; Rui Yu; Nicola K Wilson; Asuka Hira; Kenichi Yoshida; Minako Mori; Yusuke Okamoto; Yusuke Okuno; Hideki Muramatsu; Yuichi Shiraishi; Masayuki Kobayashi; Toshinori Moriguchi; Tomoo Osumi; Motohiro Kato; Satoru Miyano; Etsuro Ito; Seiji Kojima; Hiromasa Yabe; Miharu Yabe; Keitaro Matsuo; Seishi Ogawa; Berthold Göttgens; Michael R G Hodskinson; Minoru Takata; Ketan J Patel

  Molecular cell, 17 Dec. 2020, Peer-reviewed, Corresponding author

  
• USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9.

  Misaki Matsui; Ryo Sakasai; Masako Abe; Yusuke Kimura; Shoki Kajita; Wakana Torii; Yoko Katsuki; Masamichi Ishiai; Kuniyoshi Iwabuchi; Minoru Takata; Ryotaro Nishi

  Oncogenesis, 15 Jun. 2020

  
• Participation of TDP1 in the repair of formaldehyde-induced DNA-protein cross-links in chicken DT40 cells

  Toshiaki Nakano; Mahmoud Shoulkamy; Masataka Tsuda; Hiroyuki Sasanuma; Minoru Takata; Shin-ichiro Masunaga; Shunichi Takeda; Hiroshi Ide; Tadayoshi Bessho; Keizo Tano

  PLOS One, Jun. 2020, Peer-reviewed

  
• SMC5/6 acts jointly with Fanconi anemia factors to support DNA repair and genome stability.

  Francesco Rossi; Anne Helbling-Leclerc; Ryotaro Kawasumi; Nanda Kumar Jegadesan; Xinlin Xu; Pierre Devulder; Takuya Abe; Minoru Takata; Dongyi Xu; Filippo Rosselli; Dana Branzei

  EMBO reports, 05 Feb. 2020, Peer-reviewed

  
• Pilot evaluation of a HER2 testing in non-small-cell lung cancer.

  Hotta K; Yanai H; Ohashi K; Ninomiya K; Nakashima H; Kayatani H; Takata M; Kiura K

  Journal of clinical pathology, Dec. 2019, Peer-reviewed

  
• Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients.

  Minako Mori; Asuka Hira; Kenichi Yoshida; Hideki Muramatsu; Yusuke Okuno; Yuichi Shiraishi; Michiko Anmae; Jun Yasuda; Shu Tadaka; Kengo Kinoshita; Tomoo Osumi; Yasushi Noguchi; Souichi Adachi; Ryoji Kobayashi; Hiroshi Kawabata; Kohsuke Imai; Tomohiro Morio; Kazuo Tamura; Akifumi Takaori-Kondo; Masayuki Yamamoto; Satoru Miyano; Seiji Kojima; Etsuro Ito; Seishi Ogawa; Keitaro Matsuo; Hiromasa Yabe; Miharu Yabe; Minoru Takata

  Haematologica, Oct. 2019, Peer-reviewed, Last author, Corresponding author

  
• Characterization of Pathogenic Variants and Clinical Phenotypes in 117 Japanese Fanconi Anemia Patients

  Mori Minako; Hira Asuka; Yoshida Kenichi; Muramatsu Hideki; Okuno Yusuke; Anmae Michiko; Tamura Kazuo; Yasuda Jun; Osumi Tomoo; Noguchi Yasushi; Adachi Souichi; Kawabata Hiroshi; Takaori-Kondo Akifumi; Kojima Seiji; Ogawa Seishi; Yabe Hiromasa; Yabe Miharu; Takata Minoru

  BLOOD, 29 Nov. 2018, Peer-reviewed

  
• Diagnosis of Inherited Bone Marrow Failure Syndromes Using Sequencing Approaches

  Narita Atsushi; Muramatsu Hideki; Okuno Yusuke; Yoshida Kenichi; Shiraishi Yuichi; Sakaguchi Hirotoshi; Kawashima Nozomu; Wang Xinan; Xu Yinyan; Chiba Kenichi; Tanaka Hiroko; Hama Asahito; Sanada Masashi; Hitoshi Kanno; Yamaguchi Hiroki; Ohga Shouichi; Manabe Atsushi; Harigae Hideo; Kunishima Shinji; Ishii Eiichi; Kobayashi Masao; Koike Kenichi; Watanabe Kenichiro; Ito Etsuro; Takata Minoru; Yabe Miharu; Ogawa Seishi; Miyano Satoru; Kojima Seiji; Takahashi Yoshiyuki

  PEDIATRIC BLOOD & CANCER, Nov. 2018

  
• Associations of complementation group, ALDH2 genotype, and clonal abnormalities with hematological outcome in Japanese patients with Fanconi anemia.

  Yabe M; Koike T; Ohtsubo K; Imai E; Morimoto T; Takakura H; Koh K; Yoshida K; Ogawa S; Ito E; Okuno Y; Muramatsu H; Kojima S; Matsuo K; Mori M; Hira A; Takata M; Yabe H

  Ann Hematol., Oct. 2018, Peer-reviewed

  
• Warsaw breakage syndrome DDX11 helicase acts jointly with RAD17 in the repair of bulky lesions and replication through abasic sites.

  T Abe T; Ooka M; Kawasumi R; Miyata K; Takata M; Hirota K; Branzei D

  Proc Natl Acad Sci U S A, Aug. 2018, Peer-reviewed

  
• Histone Methylation by SETD1A Protects Nascent DNA through the Nucleosome Chaperone Activity of FANCD2.

  Higgs MR; Sato K; Reynolds JJ; Begum S; Bayley R; Goula A; Vernet A; Paquin KL; Skalnik DG; Kobayashi W; Takata M; Howlett NG; Kurumizaka H; Kimura H; Stewart GS

  Mol Cell, Jun. 2018, Peer-reviewed

  
• Replication stress induces accumulation of FANCD2 at central region of large fragile genes

  Yusuke Okamoto; Watal M. Iwasaki; Kazuto Kugou; Kazuki K. Takahashi; Arisa Oda; Koichi Sato; Wataru Kobayashi; Hidehiko Kawai; Ryo Sakasai; Akifumi Takaori-Kondo; Takashi Yamamoto; Masato T. Kanemaki; Masato Taoka; Toshiaki Isobe; Hitoshi Kurumizaka; Hideki Innan; Kunihiro Ohta; Masamichi Ishiai; Minoru Takata

  NUCLEIC ACIDS RESEARCH, Apr. 2018, Peer-reviewed, Last author, Corresponding author

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• ファンコニ貧血の新規原因遺伝子RFWD3/FANCWの機能解析から明らかになった相同組換え反応制御機構．

  稲野将二郎; 高田穣

  生化学, 2018, Invited

  
• ファンコニ貧血の新規原因遺伝子RFWD3の同定とその機能解析

  髙田 穰

  医学のあゆみ TOPICS, 2018, Invited

  
• PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice

  Ayako L. Mochizuki; Ami Katanaya; Eri Hayashi; Mihoko Hosokawa; Emiko Moribe; Akira Motegi; Masamichi Ishiai; Minoru Takata; Gen Kondoh; Hitomi Watanabe; Norio Nakatsuji; Shinichiro Chuma

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 2017, Peer-reviewed

  
• Activation of the FA pathway mediated by phosphorylation and ubiquitination

  Masamichi Ishiai; Koichi Sato; Junya Tomida; Hiroyuki Kitao; Hitoshi Kurumizaka; Minoru Takata

  MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Oct. 2017, Peer-reviewed, Invited

  
• Mutation Research special section "Protein modifications in DNA repair and cancer" Editorial.

  Minoru Takata

  Mutat Res., Oct. 2017, Peer-reviewed

  
• Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells

  Kei Kadoda; Takahito Moriwaki; Masataka Tsuda; Hiroyuki Sasanuma; Masamichi Ishiai; Minoru Takata; Hiroshi Ide; Shin-ichiro Masunaga; Shunichi Takeda; Keizo Tano

  PLOS ONE, Sep. 2017, Peer-reviewed

  
• Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia

  Kerstin Knies; Shojiro Inano; Maria J. Ramirez; Masamichi Ishiai; Jordi Surralles; Minoru Takata; Detlev Schindler

  JOURNAL OF CLINICAL INVESTIGATION, Aug. 2017, Peer-reviewed, Corresponding author

  
• Common Variable Immunodeficiency Caused by FANC Mutations

  Yujin Sekinaka; Noriko Mitsuiki; Kohsuke Imai; Miharu Yabe; Hiromasa Yabe; Kanako Mitsui-Sekinaka; Kenichi Honma; Masatoshi Takagi; Ayako Arai; Kenichi Yoshida; Yusuke Okuno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Hideki Muramatsu; Seiji Kojima; Asuka Hira; Minoru Takata; Osamu Ohara; Seishi Ogawa; Tomohiro Morio; Shigeaki Nonoyama

  Journal of Clinical Immunology, 01 Jul. 2017, Peer-reviewed

  
• Common Variable Immunodeficiency Caused by FANC Mutations

  Yujin Sekinaka; Noriko Mitsuiki; Kohsuke Imai; Miharu Yabe; Hiromasa Yabe; Kanako Mitsui-Sekinaka; Kenichi Honma; Masatoshi Takagi; Ayako Arai; Kenichi Yoshida; Yusuke Okuno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Hideki Muramatsu; Seiji Kojima; Asuka Hira; Minoru Takata; Osamu Ohara; Seishi Ogawa; Tomohiro Morio; Shigeaki Nonoyama

  JOURNAL OF CLINICAL IMMUNOLOGY, Jul. 2017, Peer-reviewed

  
• Fanconi貧血の新規の原因タンパク質RFWD3による相同組換えの制御.

  稲野将二郎; 佐藤浩一; 胡桃坂仁志; 高田 穣

  ライフサイエンス 新着論文レビュー, Jul. 2017

  
• RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination

  Shojiro Inano; Koichi Sato; Yoko Katsuki; Wataru Kobayashi; Hiroki Tanaka; Kazuhiro Nakajima; Shinichiro Nakada; Hiroyuki Miyoshi; Kerstin Knies; Akifumi Takaori-Kondo; Detlev Schindler; Masamichi Ishiai; Hitoshi Kurumizaka; Minoru Takata

  MOLECULAR CELL, Jun. 2017, Peer-reviewed, Last author, Corresponding author

  
• Clinical Utility of Next-generation Sequencing for Inherited Bone Marrow Failure Syndromes.

  Hideki Muramatsu; Yusuke Okuno; Kenichi Yoshida; Yuichi Shiraishi; Sayoko Doisaki; Atsushi Narita; Hirotoshi Sakaguchi; Nozomu Kawashima; Xinan Wang; Yinyan Xu; Kenichi Chiba; Hiroko Tanaka; Asahito Hama; Masashi Sanada; Yoshiyuki Takahashi; Hitoshi Kanno; Hiroki Yamaguchi; Shouichi Ohga; Atsushi Manabe; Hideo Harigae; Shinji Kunishima; Eiichi Ishii; Masao Kobayashi; Kenichi Koike; Kenichiro Watanabe; Etsuro Ito; Minoru Takata; Miharu Yabe; Seishi Ogawa; Satoru Miyano; Seiji Kojima

  Genet Med., Jan. 2017, Peer-reviewed

  
• "Protein modifications in DNA repair and cancer" Editorial.

  TAKATA Minoru

  Mutation Research special section, 2017, Peer-reviewed, Invited

  
• 新規Fanconi anemia 遺伝子RFWD3/FANCWの発見と機能解明。

  稲野将二郎; 高田穣

  小児血液がん学会誌, 2017, Invited

  
• FANCI-FANCD2 stabilizes the RAD51-DNA complex by binding RAD51 and protects the 5 '-DNA end

  Koichi Sato; Mayo Shimomuki; Yoko Katsuki; Daisuke Takahashi; Wataru Kobayashi; Masamichi Ishiai; Hiroyuki Miyoshi; Minoru Takata; Hitoshi Kurumizaka

  NUCLEIC ACIDS RESEARCH, Dec. 2016, Peer-reviewed

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• Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks

  Chen Ling; Jing Huang; Zhijiang Yan; Yongjiang Li; Mioko Ohzeki; Masamichi Ishiai; Dongyi Xu; Minoru Takata; Michael Seidman; Weidong Wang

  CELL DISCOVERY, Dec. 2016, Peer-reviewed

  
• The phenotype and clinical course of Japanese Fanconi Anaemia infants is influenced by patient, but not maternal ALDH2 genotype

  Miharu Yabe; Hiromasa Yabe; Tsuyoshi Morimoto; Akiko Fukumura; Keisuke Ohtsubo; Takashi Koike; Kenichi Yoshida; Seishi Ogawa; Etsuro Ito; Yusuke Okuno; Hideki Muramatsu; Seiji Kojima; Keitaro Matsuo; Asuka Hira; Minoru Takata

  BRITISH JOURNAL OF HAEMATOLOGY, Nov. 2016, Peer-reviewed

  
• Defects in homologous recombination repair behind the human diseases: FA and HBOC

  Yoko Katsuki; Minoru Takata

  ENDOCRINE-RELATED CANCER, Oct. 2016, Peer-reviewed

  
• Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.

  Kiyohiro Hashimoto; Vyom Sharma; Hiroyuki Sasanuma; Xu Tian; Minoru Takata; Shunichi Takeda; James A Swenberg; Jun Nakamura

  Oncotarget, 13 Sep. 2016, Peer-reviewed

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• Effect of Vandetanib on Lung Tumorigenesis in Transgenic Mice Carrying an Activating Egfr Gene Mutation

  Masahiro Osawa; Kadoaki Ohashi; Toshio Kubo; Eiki Ichihara; Saburo Takata; Nagio Takigawa; Minoru Takata; Mitsune Tanimoto; Katsuyuki Kiura

  ACTA MEDICA OKAYAMA, Aug. 2016, Peer-reviewed

  
• The fanconi anemia pathway and interstrand cross-link repair

  Masamichi Ishiai; Junya Tomida; Akiko Itaya; James Hejna; Minoru Takata

  DNA Replication, Recombination, and Repair: Molecular Mechanisms and Pathology, 01 Jan. 2016, Peer-reviewed

  
• Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.

  Xu Tian; Keyur Patel; John R Ridpath; Youjun Chen; Yi-Hui Zhou; Dayna Neo; Jean Clement; Minoru Takata; Shunichi Takeda; Julian Sale; Fred A Wright; James A Swenberg; Jun Nakamura

  PloS one, 2016, Peer-reviewed

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• Conserved Overlapping Gene Arrangement, Restricted Expression, and Biochemical Activities of DNA Polymerase nu (POLN)

  Kei-ichi Takata; Junya Tomida; Shelley Reh; Lisa M. Swanhart; Minoru Takata; Neil A. Hukriede; Richard D. Wood

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2015, Peer-reviewed

  
• Human FAN1 promotes strand incision in 5 '-flapped DNA complexed with RPA

  Daisuke Takahashi; Koichi Sato; Emiko Hirayama; Minoru Takata; Hitoshi Kurumizaka

  JOURNAL OF BIOCHEMISTRY, Sep. 2015, Peer-reviewed

  
• Mutations in the Gene Encoding the E2 Conjugating Enzyme UBE2T Cause Fanconi Anemia

  Asuka Hira; Kenichi Yoshida; Koichi Sato; Yusuke Okuno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Akira Shimamoto; Hidetoshi Tahara; Etsuro Ito; Seiji Kojima; Hitoshi Kurumizaka; Seishi Ogawa; Minoru Takata; Hiromasa Yabe; Miharu Yabe

  AMERICAN JOURNAL OF HUMAN GENETICS, Jun. 2015, Peer-reviewed, Corresponding author

  
• Comprehensive analysis of Japanese Fanconi anemia (FA) patients has led to the identification of an E2 enzyme UBE2T as a novel FA gene

  Minoru Takata; Asuka Hira; Kenichi Yoshida; Koichi Sato; Akira Shimamoto; Hidetoshi Tahara; Hitoshi Kurumizaka; Seishi Ogawa; Hiromasa Yabe; Miharu Yabe

  DNA REPAIR, Apr. 2015

  
• Pluripotent Cell Models of Fanconi Anemia Identify the Early Pathological Defect in Human Hemoangiogenic Progenitors

  Naoya M. Suzuki; Akira Niwa; Miharu Yabe; Asuka Hira; Chihiro Okada; Naoki Amano; Akira Watanabe; Ken-Ichiro Watanabe; Toshio Heike; Minoru Takata; Tatsutoshi Nakahata; Megumu K. Saita

  STEM CELLS TRANSLATIONAL MEDICINE, Apr. 2015, Peer-reviewed

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• 細胞シグナル操作法 「DNA修復」

  石合正道; 高田 穣

  生体の科学 増大特集, 2015, Invited

  
• Defective FANCI Binding by a Fanconi Anemia-Related FANCD2 Mutant

  Koichi Sato; Masamichi Ishiai; Minoru Takata; Hitoshi Kurumizaka

  PLOS ONE, Dec. 2014, Peer-reviewed

  
• Expression and purification of human FANCI and FANCD2 using Escherichia coli cells

  Daisuke Takahashi; Koichi Sato; Mayo Shimomuki; Minoru Takata; Hitoshi Kurumizaka

  PROTEIN EXPRESSION AND PURIFICATION, Nov. 2014, Peer-reviewed

  
• The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells

  Kei Ishii; Masamichi Ishiai; Hiroko Morimoto; Mito Kanatsu-Shinohara; Ohtsura Niwa; Minoru Takata; Takashi Shinohara

  STEM CELL REPORTS, Oct. 2014, Peer-reviewed

  
• Modularized Functions of the Fanconi Anemia Core Complex

  Yaling Huang; Justin W. C. Leung; Megan Lowery; Nobuko Matsushita; Yucai Wang; Xi Shen; Do Huong; Minoru Takata; Junjie Chen; Lei Li

  CELL REPORTS, Jun. 2014, Peer-reviewed

  
• FANCD2 Binds CtIP and Regulates DNA-End Resection during DNA Interstrand Crosslink Repair

  Junya Unno; Akiko Itaya; Masato Taoka; Koichi Sato; Junya Tomida; Wataru Sakai; Kaoru Sugasawa; Masamichi Ishiai; Tsuyoshi Ikura; Toshiaki Isobe; Hitoshi Kurumizaka; Minoru Takata

  CELL REPORTS, May 2014, Peer-reviewed, Last author, Corresponding author

  
• Tumor suppressor RecQL5 controls recombination induced by DNA crosslinking agents

  Yoshifumi Hosono; Takuya Abe; Masamichi Ishiai; M. Nurul Islam; Hiroshi Arakawa; Weidong Wang; Shunichi Takeda; Yutaka Ishii; Minoru Takata; Masayuki Seki; Takemi Enomoto

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, May 2014, Peer-reviewed

  
• Multiple genetic manipulations of DT40 cell line

  Akira Motegi; Minoru Takata

  Methods in Molecular Biology, 01 Jan. 2014, Peer-reviewed

  
• Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients.

  Asuka Hira; Hiromasa Yabe; Kenichi Yoshida; Yusuke Okuno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Jun Nakamura; Seiji Kojima; Seishi Ogawa; Keitaro Matsuo; Minoru Takata; Miharu Yabe

  Blood, 31 Oct. 2013, Peer-reviewed

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• [Fanconi anemia and the molecular mechanism of the repair of DNA crosslinks

  Hira A; Takata M

  Rinsho Ketsueki., Oct. 2013, Invited

  
• A novel interplay between the Fanconi anemia core complex and ATR-ATRIP kinase during DNA cross-link repair

  Junya Tomida; Akiko Itaya; Tomoko Shigechi; Junya Unno; Emi Uchida; Masae Ikura; Yuji Masuda; Shun Matsuda; Jun Adachi; Masahiko Kobayashi; Amom Ruhikanta Meetei; Yoshihiko Maehara; Ken-ichi Yamamoto; Kenji Kamiya; Akira Matsuura; Tomonari Matsuda; Tsuyoshi Ikura; Masamichi Ishiai; Minoru Takata

  NUCLEIC ACIDS RESEARCH, Aug. 2013, Peer-reviewed

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• NBS1 directly activates ATR independently of MRE11 and TOPBP1

  Masahiko Kobayashi; Naoyuki Hayashi; Minoru Takata; Ken-ichi Yamamoto

  GENES TO CELLS, Mar. 2013, Peer-reviewed

  
• Synergistic effect of olaparib with combination of cisplatin on PTEN-deficient lung cancer cells

  Daisuke Minami; Nagio Takigawa; Hiromasa Takeda; Minoru Takata; Nobuaki Ochi; Eiki Ichihara; Akiko Hisamoto; Katsuyuki Hotta; Mitsune Tanimoto; Katsuyuki Kiura

  Molecular Cancer Research, Feb. 2013, Peer-reviewed

  
• 染色体脆弱部位の複製とDNA損傷ストレス応答のメカニズム

  髙田 穰

  実験医学, Sep. 2012, Invited

  
• Mcm8 and Mcm9 Form a Complex that Functions in Homologous Recombination Repair Induced by DNA Interstrand Cross links

  Kohei Nishimura; Masamichi Ishiai; Kazuki Horikawa; Tatsuo Fukagawa; Minoru Takata; Haruhiko Takisawa; Masato T. Kanemaki

  MOLECULAR CELL, Aug. 2012, Peer-reviewed

  
• Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

  Koichi Sato; Masamichi Ishiai; Kazue Toda; Satoshi Furukoshi; Akihisa Osakabe; Hiroaki Tachiwana; Yoshimasa Takizawa; Wataru Kagawa; Hiroyuki Kitao; Naoshi Dohmae; Chikashi Obuse; Hiroshi Kimura; Minoru Takata; Hitoshi Kurumizaka

  EMBO JOURNAL, Aug. 2012, Peer-reviewed

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• A Ubiquitin-Binding Protein, FAAP20, Links RNF8-Mediated Ubiquitination to the Fanconi Anemia DNA Repair Network

  Zhijiang Yan; Rong Guo; Manikandan Paramasivam; Weiping Shen; Chen Ling; David Fox; Yucai Wang; Anneke B. Oostra; Julia Kuehl; Duck-Yeon Lee; Minoru Takata; Maureen E. Hoatlin; Detlev Schindler; Hans Joenje; Johan P. de Winter; Lei Li; Michael M. Seidman; Weidong Wang

  MOLECULAR CELL, Jul. 2012, Peer-reviewed

  
• Matched sibling donor stem cell transplantation for Fanconi anemia patients with T-cell somatic mosaicism

  Miharu Yabe; Takashi Shimizu; Tsuyoshi Morimoto; Takashi Koike; Hiromitsu Takakura; Hideo Tsukamoto; Kazuo Muroi; Koichi Oshima; Keiko Asami; Minoru Takata; Takayuki Yamashita; Shunichi Kato; Hiromasa Yabe

  PEDIATRIC TRANSPLANTATION, Jun. 2012, Peer-reviewed

  
• DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI

  Koichi Sato; Kazue Toda; Masamichi Ishiai; Minoru Takata; Hitoshi Kurumizaka

  NUCLEIC ACIDS RESEARCH, May 2012, Peer-reviewed

  
• Defining the molecular interface that connects the Fanconi anemia protein FANCM to the Bloom syndrome dissolvasome

  Kelly A. Hoadley; Yutong Xue; Chen Ling; Minoru Takata; Weidong Wang; James L. Keck

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2012, Peer-reviewed

  
• ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity.

  Yoshihiko Fujinaka; Kazuaki Matsuoka; Makoto Iimori; Munkhbold Tuul; Ryo Sakasai; Keiji Yoshinaga; Hiroshi Saeki; Masaru Morita; Yoshihiro Kakeji; David A Gillespie; Ken-Ichi Yamamoto; Minoru Takata; Hiroyuki Kitao; Yoshihiko Maehara

  DNA repair, 01 Mar. 2012, Peer-reviewed

  
• ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway

  Tomoko Shigechi; Junya Tomida; Koichi Sato; Masahiko Kobayashi; John K. Eykelenboom; Fabio Pessina; Yanbin Zhang; Emi Uchida; Masamichi Ishiai; Noel F. Lowndes; Kenichi Yamamoto; Hitoshi Kurumizaka; Yoshihiko Maehara; Minoru Takata

  CANCER RESEARCH, Mar. 2012, Peer-reviewed

  
• ゲノムDNA 損傷応答ネットワーク解明の新展開

  石合正道; 髙田穣

  メディカル・サイエンス・ダイジェ スト 特集「DNA 損傷応答ネットワークと疾患」特集編輯 髙田穣,38(1), 14-16,2012, 2012, Peer-reviewed

  
• Establishment of the DNA repair-defective mutants in DT40 cells

  Masamichi Ishiai; Emi Uchida; Minoru Takata

  Methods in Molecular Biology, 2012, Peer-reviewed

  
• Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway

  Ivan V. Rosado; Frédéric Langevin; Gerry P. Crossan; Minoru Takata; Ketan J. Patel

  Nature Structural and Molecular Biology, Dec. 2011, Peer-reviewed

  
• Predisposition to Cancer Caused by Genetic and Functional Defects of Mammalian Atad5

  Daphne W. Bell; Nilabja Sikdar; Kyoo-young Lee; Jessica C. Price; Raghunath Chatterjee; Hee-Dong Park; Jennifer Fox; Masamichi Ishiai; Meghan L. Rudd; Lana M. Pollock; Sarah K. Fogoros; Hassan Mohamed; Christin L. Hanigan; Suiyuan Zhang; Pedro Cruz; Gabriel Renaud; Nancy F. Hansen; Praveen F. Cherukuri; Bhavesh Borate; Kirk J. McManus; Jan Stoepel; Payal Sipahimalani; Andrew K. Godwin; Dennis C. Sgroi; Maria J. Merino; Gene Elliot; Abdel Elkahloun; Charles Vinson; Minoru Takata; James C. Mullikin; Tyra G. Wolfsberg; Philip Hieter; Dae-Sik Lim; Kyungjae Myung

  PLOS GENETICS, Aug. 2011, Peer-reviewed

  
• Direct Inhibition of TNF-alpha Promoter Activity by Fanconi Anemia Protein FANCD2

  Nobuko Matsushita; Yujiro Endo; Koichi Sato; Hitoshi Kurumizaka; Takayuki Yamashita; Minoru Takata; Shigeru Yanagi

  PLOS ONE, Aug. 2011, Peer-reviewed

  
• USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation

  Jean-Hugues Guervilly; Emilie Renaud; Minoru Takata; Filippo Rosselli

  HUMAN MOLECULAR GENETICS, Jun. 2011, Peer-reviewed

  
• FancJ/Brip1 helicase protects against genomic losses and gains in vertebrate cells

  Hiroyuki Kitao; Indrajit Nanda; Ryuichi P. Sugino; Aiko Kinomura; Mitsuyoshi Yamazoe; Hiroshi Arakawa; Michael Schmid; Hideki Innan; Kevin Hiom; Minoru Takata

  GENES TO CELLS, Jun. 2011, Peer-reviewed

  
• Fanconi anemia: a disorder defective in the DNA damage response

  Hiroyuki Kitao; Minoru Takata

  INTERNATIONAL JOURNAL OF HEMATOLOGY, Apr. 2011, Peer-reviewed

  
• Fanconi anemia and the DNA damage response

  Minoru Takata

  INTERNATIONAL JOURNAL OF HEMATOLOGY, Apr. 2011, Peer-reviewed

  
• Involvement of SLX4 in interstrand cross-link repair is regulated by the Fanconi anemia pathway

  Kimiyo N. Yamamoto; Shunsuke Kobayashi; Masataka Tsuda; Hitoshi Kurumizaka; Minoru Takata; Koichi Kono; Josef Jiricny; Shunichi Takeda; Kouji Hirota

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2011, Peer-reviewed

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• Evaluation of Homologous Recombinational Repair in Chicken B Lymphoma Cell Line, DT40

  Hiroyuki Kitao; Seiki Hirano; Minoru Takata

  Methods in Molecular Biology, Apr. 2011, Peer-reviewed, Invited

  
• KIAA1018/FAN1 nuclease protects cells against genomic instability induced by interstrand cross-linking agents

  Kazunori Yoshikiyo; Katja Kratz; Kouji Hirota; Kana Nishihara; Minoru Takata; Hitoshi Kurumizaka; Satoshi Horimoto; Shunichi Takeda; Josef Jiricny

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2010, Peer-reviewed

  
• ファンコニ貧血原因遺伝子群の機能と調節機構

  茂地 智子; 高田 穣

  G.I.Resarch (Journal of Gastrointestinal Research)特集/DNA修復機能異常と疾患, Apr. 2010, Invited

  
• ファンコニ貧血の分子メカニズム

  板谷亜希子; 高田穣

  血液診療エキスパート：貧血』中外医学社 215-17, Feb. 2010, Invited

  
• ＤＮＡクロスリンク損傷修復の分子機構

  冨田純也; 高田 穣

  細胞工学 特集号, Jan. 2010, Peer-reviewed

  
• Fanconi貧血におけるゲノム不安定性メカニズム

  板谷亜希子; 高田 穣

  臨床血液 51:546-552, 2010, Peer-reviewed, Invited

  
• Chemopreventive Effects of Gefitinib on Nonsmoking-Related Lung Tumorigenesis in Activating Epidermal Growth Factor Receptor Transgenic Mice

  Kadoaki Ohashi; Nagio Takigawa; Masahiro Osawa; Eiki Ichihara; Hiromasa Takeda; Toshio Kubo; Seiki Hirano; Tadashi Yoshino; Minoru Takata; Mitsune Tanimoto; Katsuyuki Kiura

  CANCER RESEARCH, Sep. 2009, Peer-reviewed

  
• The Fanconi anemia pathway: Insights from somatic cell genetics using DT40 cell line

  Minoru Takata; Masamichi Ishiai; Hiroyuki Kitao

  MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Jul. 2009, Peer-reviewed

  
• ファンコニ貧血とDNA損傷応答ネットワーク(染色体サイクル ゲノムの恒常性維持、継承とダイナミクス)

  松下暢子; 北尾洋之; 石合正道; 髙田穣

  蛋白質核酸酵素54(4)580-585, Mar. 2009, Invited

  
• ファンコニ貧血とDNA損傷応答ネットワーク

  松下暢子; 北尾洋之; 石合正道; 高田穣

  蛋白質核酸酵素 増刊 染色体サイクル ゲノムの恒常性維持、継承とダイナミクス 編集 正井久雄 舛方久夫 釣本敏樹 篠原彰, Mar. 2009

  
• [Fanconi anemia and DNA-damage response network].

  N. Matsushita; H. Kitao; M. Ishiai; M. Takata

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2009, Peer-reviewed

  
• EGFR変異とUracil-Tegafurによる肺腺癌術後補助療法の関連性についての検討

  末久 弘; 豊岡 伸一; 堀田 勝幸; 内田 亜希子; 宗 淳一; 藤原 義朗; 松尾 恵太郎; 大内田 守; 高田 穣; 木浦 勝行; 伊達 洋至

  岡山医学会雑誌, Dec. 2008

  
• KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation

  Takuya Abe; Masamichi Ishiai; Yoshifumi Hosono; Akari Yoshimura; Shusuke Tada; Noritaka Adachi; Hideki Koyama; Minoru Takata; Shunichi Takeda; Takemi Enomoto; Masayuki Seki

  CELLULAR SIGNALLING, Nov. 2008, Peer-reviewed

  
• FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway

  Masamichi Ishiai; Hiroyuki Kitao; Agata Smogorzewska; Junya Tomida; Aiko Kinomura; Emi Uchida; Alihossein Saberi; Eiji Kinoshita; Emiko Kinoshita-Kikuta; Tohru Koike; Satoshi Tashiro; Stephen J. Elledge; Minoru Takata

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Nov. 2008, Peer-reviewed

  
• 喫煙と関連性が低い肺癌マウスモデルに対するゲフィチニブの化学予防効果(Chemopreventive Effect of Gefitinib on Smoking-unrelated Lung Cancer Mouse Model)

  大橋 圭明; 大澤 昌宏; 久保 寿夫; 武田 洋正; 市原 英基; 堀田 勝幸; 平木 章夫; 瀧川 奈義夫; 吉野 正; 田端 雅弘; 高田 穣; 木浦 勝行; 谷本 光音

  日本癌学会総会記事, Sep. 2008

  
• Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter.

  Kadoaki Ohashi; Kammei Rai; Yoshiro Fujiwara; Masahiro Osawa; Seiki Hirano; Katsuyoshi Takata; Eisaku Kondo; Tadashi Yoshino; Minoru Takata; Mitsune Tanimoto; Katsuyuki Kiura

  Cancer science, Sep. 2008, Peer-reviewed

  
• Enhancement of radiation induced cell death in chicken B lymphocytes by withaferin A

  P. Uma Devi; H. Utsumi; M. Takata; S. Takeda

  INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, Jun. 2008, Peer-reviewed

  
• FANCG promotes formation of a newly identified protein complex containing BRCA2, FANCD2 and XRCC3

  J. B. Wilson; K. Yamamoto; A. S. Marriott; S. Hussain; P. Sung; M. E. Hoatlin; C. G. Mathew; M. Takata; L. H. Thompson; G. M. Kupfer; N. J. Jones

  ONCOGENE, Jun. 2008, Peer-reviewed

  
• Regulation of histone H4 acetylation by transcription factor E2A in Ig gene conversion

  Hiroyuki Kitao; Masayo Kimura; Kazuhiko Yamamoto; Hidetaka Seo; Keiko Namikoshi; Yasutoshi Agata; Kunihiro Ohta; Minoru Takata

  INTERNATIONAL IMMUNOLOGY, Feb. 2008, Peer-reviewed

  
• Detection of phosphorylation on large proteins by western blotting using Phos-tag containing gel.

  Tomida, J; Kitao, H; Kinoshita, E; Takata, M

  Nature Protocols doi:10.1038/nprot.232, 2008, Peer-reviewed

  
• Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde

  John R. Ridpath; Ayumi Nakamura; Keizo Tano; April M. Luke; Eiichiro Sonoda; Hiroshi Arakawa; Jean-Marie Buerstedde; David A. F. Gillespie; Julian E. Sale; Mitsuyoshi Yamazoe; Douglas K. Bishop; Minoru Takata; Shunichi Takeda; Masami Watanabe; James A. Swenberg; Jun Nakamura

  CANCER RESEARCH, Dec. 2007, Peer-reviewed

  
• EGFR変異とUFTによる肺腺癌術後補助療法の関連性についての検討

  末久 弘; 豊岡 伸一; 堀田 勝幸; 内田 亜希子; 宗 淳一; 藤原 義朗; 松尾 恵太郎; 大内田 守; 高田 穣; 木浦 勝行; 伊達 洋至

  肺癌, Oct. 2007

  
• Subcellular distribution of human RDM1 protein isoforms and their nucleolar accumulation in response to heat shock and proteotoxic stress

  Lydia Messaoudi; Yun-Gui Yang; Aiko Kinomura; Diana A. Stavreva; Gonghong Yan; Marie-Line Bortolin-Cavaille; Hiroshi Arakawa; Jean-Marie Buerstedde; Pierre Hainaut; Jerome Cavaille; Minoru Takata; Eric Van Dyck

  NUCLEIC ACIDS RESEARCH, Oct. 2007, Peer-reviewed

  
• Epidermal growth factor receptor mutation status and adjuvant chemotherapy with uracil-tegafur for adenocarcinoma of the lung

  Hiroshi Suehisa; Shinichi Toyooka; Katsuyuki Hotta; Akiko Uchida; Junichi Soh; Yoshiro Fujiwara; Keitaro Matsuo; Mamoru Ouchida; Minoru Takata; Katsuyuki Kiura; Hiroshi Date

  JOURNAL OF CLINICAL ONCOLOGY, Sep. 2007, Peer-reviewed

  
• マウスEGFR変異組み換えネズミにおける肺腺癌の発生(Transgenic mice with mouse Egfr mutation developed lung adenocarcinoma)

  大橋 圭明; 木浦 勝行; 頼 冠名; 大澤 昌宏; 平野 世紀; 藤原 義朗; 内田 亜希子; 荻野 敦子; 瀧川 奈義夫; 田端 雅弘; 吉野 正; 高田 穣; 谷本 光音

  日本癌学会総会記事, Aug. 2007

  
• Emergence of epidermal growth factor receptor T790M mutation during chronic exposure to gefitinib in a non-small cell lung cancer cell line

  Atsuko Ogino; Hiroyuki Kitao; Seiki Hirano; Akiko Uchida; Masamichi Ishiai; Toshiyuki Kozuki; Nagio Takigawa; Minoru Takata; Katsuyuki Kiura; Mitsune Tanimoto

  CANCER RESEARCH, Aug. 2007, Peer-reviewed

  
• EGFR変異とUFTによる肺腺癌術後補助療法の関連性についての検討

  末久 弘; 豊岡 伸一; 堀田 勝幸; 内田 亜希子; 宗 淳一; 木浦 勝行; 浅野 博昭; 藤原 義朗; 松尾 恵太郎; 青江 基; 高田 穣; 清水 信義; 伊達 洋至

  日本呼吸器外科学会雑誌, Apr. 2007

  
• FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway

  Chen Ling; Masamichi Ishiai; Abdullah Mahmood Ali; Annette L. Medhurst; Kornelia Neveling; Reinhard Kalb; Zhijiang Yan; Yutong Xue; Anneke B. Oostra; Arleen D. Auerbach; Maureen E. Hoatlin; Detlev Schindler; Hans Joenje; Johan P. de Winter; Minoru Takata; Amom Ruhikanta Meetei; Weidong Wang

  EMBO JOURNAL, Apr. 2007, Peer-reviewed

  
• The effect of gefitinib on B-RAF mutant non-small cell lung cancer and transfectants

  Shinichi Toyooka; Akiko Uchida; Hisayuki Shigematsu; Junichi Soh; Atsuko Ogino; Minoru Takata; Katsuyuki Kiura; Mamoru Ouchida; Takayuki Kosaka; Motoi Aoe; Tetsuya Mitsudomi; Hiroshi Date

  Journal of Thoracic Oncology, Apr. 2007, Peer-reviewed

  
• A requirement of FancL and FancD2 monoubiquitination in DNA repair

  Sohsuke Seki; Mioko Ohzeki; Akiko Uchida; Seiki Hirano; Nobuko Matsushita; Hiroyuki Kitao; Tsukasa Oda; Takayuki Yamashita; Naoki Kashihara; Akio Tsubahara; Minoru Takata; Masamichi Ishiai

  GENES TO CELLS, Mar. 2007, Peer-reviewed

  
• Fanconi anemia: genetic analysis of a human disease using chicken system

  M. Takata; H. Kitao; M. Ishiai

  CYTOGENETIC AND GENOME RESEARCH, 2007, Peer-reviewed

  
• 53BP1 contributes to survival of cells irradiated with X-ray during G1 without Ku70 or Artemis

  Kuniyoshi Iwabuchi; Mitsumasa Hashimoto; Tadashi Matsui; Takayuki Kurihara; Hiroko Shimizu; Noritaka Adachi; Masamichi Ishiai; Ken-Ichi Yamamoto; Hiroshi Tauchi; Minoru Takata; Hideki Koyama; Takayasu Date

  Genes to Cells, Aug. 2006, Peer-reviewed

  
• Functional interplay between BRCA2/FancD1 and FancC in DNA repair

  Hiroyuki Kitao; Kazuhiko Yamamoto; Nobuko Matsushita; Mioko Ohzeki; Masamichi Ishiai; Minoru Takata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2006, Peer-reviewed

  
• Purification of TAP-tagged proteins by two-step pull down from DT40 cells.

  Kitao H; Takata M

  Sub-cellular biochemistry, 2006, Peer-reviewed

  
• The fanconi anemia pathway promotes homologous recombination repair in DT40 cell line.

  M. Takata; K. Yamamoto; N. Matsushita; H. Kitao; S. Hirano; M. Ishiai

  Sub-cellular biochemistry, 2006, Peer-reviewed

  
• Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells

  K Nojima; H Hochegger; A Saberi; T Fukushima; K Kikuchi; M Yoshimura; BJ Orelli; DK Bishop; S Hirano; M Ohzeki; M Ishiai; K Yamamoto; M Takata; H Arakawa; JM Buerstedde; M Yamazoe; T Kawamoto; K Araki; JA Takahashi; N Hashimoto; S Takeda; E Sonoda

  CANCER RESEARCH, Dec. 2005, Peer-reviewed

  
• A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair

  N Matsushita; H Kitao; M Ishiai; N Nagashima; S Hirano; K Okawa; T Ohta; DS Yu; PJ McHugh; ID Hickson; AR Venkitaraman; H Kurumizaka; M Takata

  MOLECULAR CELL, Sep. 2005, Peer-reviewed

  
• Role of NAD-dependent deacetylases SIRT1 and SIRT2 in radiation and cisplatin-induced cell death in vertebrate cells

  N Matsushita; Y Takami; M Kimura; S Tachiiri; M Ishiai; T Nakayama; M Takata

  GENES TO CELLS, Apr. 2005, Peer-reviewed

  
• RDM1, a novel RNA recognition motif (RRM)-containing protein involved in the cell response to cisplatin in vertebrates

  S Hamimes; H Arakawa; AZ Stasiak; AM Kierzek; S Hirano; YG Yang; M Takata; A Stasiak; JM Buerstedde; E Van Dyck

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2005, Peer-reviewed

  
• Similar effects of BRCA2 truncation and Rad51 paralog deficiency on immunoglobulin V gene diversification in DT40 cells support an early role for Rad51 paralogs in homologous recombination

  A Hatanaka; M Yamazoe; JE Sale; M Takata; K Yamamoto; H Kitao; E Sonoda; K Kikuchi; Y Yonetani; S Takeda

  MOLECULAR AND CELLULAR BIOLOGY, Feb. 2005, Peer-reviewed

  
• Fanconi anemia protein FANCD2 promotes immunoglobulin gene conversion and DNA repair through a mechanism related to homologous recombination

  K Yamamoto; S Hirano; M Ishiai; K Morishima; H Kitao; K Namikoshi; M Kimura; N Matsushita; H Arakawa; JM Buerstedde; K Komatsu; LH Thompson; M Takata

  MOLECULAR AND CELLULAR BIOLOGY, Jan. 2005, Peer-reviewed

  
• Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM

  S Hirano; K Yamamoto; M Ishiai; M Yamazoe; M Seki; N Matsushita; M Ohzeki; YM Yamashita; H Arakawa; JM Buerstedde; T Enomoto; S Takeda; LH Thompson; M Takata

  EMBO JOURNAL, Jan. 2005, Peer-reviewed

  
• DNA cross-link repair protein SNM1A interacts with PIAS1 in nuclear focus formation

  M Ishiai; M Kimura; K Namikoshi; M Yamazoe; K Yamamoto; H Arakawa; K Agematsu; N Matsushita; S Takeda; JM Buerstedde; M Takata

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 2004, Peer-reviewed

  
• Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks

  MS Sasaki; M Takata; E Sonoda; A Tachibana; S Takeda

  CYTOGENETIC AND GENOME RESEARCH, 2004, Peer-reviewed

  
• Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells

  K Yamamoto; M Ishiai; N Matsushita; H Arakawa; JE Lamerdin; JM Buerstedde; M Tanimoto; M Harada; LH Thompson; M Takata

  MOLECULAR AND CELLULAR BIOLOGY, Aug. 2003, Peer-reviewed

  
• DNA-PK: the major target for wortmannin-mediated radiosensitization by the inhibition of DSB repair via NHEJ pathway

  M Hashimoto; S Rao; O Tokuno; KI Yamamoto; M Takata; S Takeda; H Utsumi

  JOURNAL OF RADIATION RESEARCH, Jun. 2003, Peer-reviewed

  
• Multiple roles of Rev3, the catalytic subunit of pole in maintaining genome stability in vertebrates

  E Sonoda; T Okada; GY Zhaol; S Tateishi; K Araki; M Yarnaizumi; T Yagi; NS Verkaik; DC van Gent; M Takata; S Takeda

  EMBO JOURNAL, Jun. 2003, Peer-reviewed

  
• Involvement of vertebrate Polκ in Rad18-independent postreplication repair of UV damage

  Takashi Okada; Eiichiro Sonoda; Yukiko M. Yamashita; Shogo Koyoshi; Satoshi Tateishi; Masaru Yamaizumi; Minoru Takata; Osamu Ogawa; Shunichi Takeda

  Journal of Biological Chemistry, 13 Dec. 2002, Peer-reviewed

  
• Nbs1 is essential for DNA repair by homologous recombination in higher vertebrate cells

  H Tauchi; J Kobayashi; K Morishima; DC van Gent; T Shiraishi; NS Verkaik; D vanHeems; E Ito; A Nakamura; E Sonodo; M Takata; S Takeda; S Matsuura; K Komatsu

  NATURE, Nov. 2002, Peer-reviewed

  
• Conserved domains in the chicken homologue of BRCA2

  M Takata; S Tachiiri; A Fujimori; LH Thompson; Y Miki; M Hiraoka; S Takeda; M Yamazaoe

  ONCOGENE, Feb. 2002, Peer-reviewed

  
• Effects of double-strand break repair proteins on vertebrate telomere structure

  C. Wei; R. Skopp; M. Takata; S. Takeda; C.M. Price

  Nucleic Acids Research, 2002, Peer-reviewed

  
• Genetic Analysis of the DNA-dependent Protein Kinase Reveals an Inhibitory Role of Ku in Late S-G2 Phase DNA Double-strand Break Repair

  Toru Fukushima; Minoru Takata; Ciaran Morrison; Ryoko Araki; Akira Fujimori; Masumi Abe; Kouichi Tatsumi; Maria Jasin; Pawan Kumar Dhar; Eiichiro Sonoda; Tsutomu Chiba; Shunichi Takeda

  Journal of Biological Chemistry, 30 Nov. 2001, Peer-reviewed

  
• Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells

  A Fujimori; S Tachiiri; E Sonoda; LH Thompson; PK Dhar; M Hiraoka; S Takeda; Y Zhang; M Reth; M Takata

  EMBO JOURNAL, Oct. 2001, Peer-reviewed

  
• Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation [4]

  Julian E. Sale; Daniella M. Calandrini; Minoru Takata; Shunichi Takeda; Michael S. Neuberger

  Nature, 30 Aug. 2001, Peer-reviewed

  
• Requirement for repair of DNA double-strand breaks by homologous recombination in split-dose recovery

  H Utsumi; K Tano; M Takata; S Takeda; MM Elkind

  RADIATION RESEARCH, May 2001, Peer-reviewed

  
• Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group

  HC Wang; ZC Zeng; TA Bui; E Sonoda; M Takata; S Takeda; G Iliakis

  ONCOGENE, Apr. 2001, Peer-reviewed

  
• Chromosome instability and defective recombinational repair in knockout mutants of the five Rad51 paralogs

  M Takata; MS Sasaki; S Tachiiri; T Fukushima; E Sonoda; D Schild; LH Thompson; S Takeda

  MOLECULAR AND CELLULAR BIOLOGY, Apr. 2001, Peer-reviewed

  
• Homologous DNA recombination is essential for the proliferation of vertebrate cells

  E. Sonoda; M. Takata; Y.M. Yamashita; S. Takeda

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2001, Peer-reviewed

  
• Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40

  E Sonoda; C Morrison; YM Yamashita; M Takata; S Takeda

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, Jan. 2001, Peer-reviewed

  
• The Rad51 paralog Rad51B promotes homologous recombinational repair

  M Takata; MS Sasaki; E Sonoda; T Fukushima; C Morrison; JS Albala; SMA Swagemakers; R Kanaar; LH Thompson; S Takeda

  MOLECULAR AND CELLULAR BIOLOGY, Sep. 2000, Peer-reviewed

  
• Regulation of the phospholipase C-gamma 2 pathway in B cells

  T Kurosaki; A Maeda; M Ishiai; A Hashimoto; K Inabe; M Takata

  IMMUNOLOGICAL REVIEWS, Aug. 2000, Peer-reviewed

  
• Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

  Y Yamaguchi-Iwai; E Sonoda; MS Sasaki; C Morrison; T Haraguchi; Y Hiraoka; YM Yamashita; T Yagi; M Takata; C Price; N Kakazu; S Takeda

  EMBO JOURNAL, Dec. 1999, Peer-reviewed

  
• The essential functions of human Rad51 are independent of ATP hydrolysis

  C Morrison; A Shinohara; E Sonoda; Y Yamaguchi-Iwai; M Takata; RR Weichselbaum; S Takeda

  MOLECULAR AND CELLULAR BIOLOGY, Oct. 1999, Peer-reviewed

  
• Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells

  E Sonoda; MS Sasaki; C Morrison; Y Yamaguchi-Iwai; M Takata; S Takeda

  MOLECULAR AND CELLULAR BIOLOGY, Jul. 1999, Peer-reviewed

  
• Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52

  Y Yamaguchi-Iwai; E Sonoda; JM Buerstedde; O Bezzubova; C Morrison; M Takata; A Shinohara; S Takeda

  MOLECULAR AND CELLULAR BIOLOGY, Nov. 1998, Peer-reviewed

  
• Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

  M Takata; MS Sasaki; E Sonoda; C Morrison; M Hashimoto; H Utsumi; Y Yamaguchi-Iwai; A Shinohara; S Takeda

  EMBO JOURNAL, Sep. 1998, Peer-reviewed

  
• Recombinational repair is essential for the maintenance of chromosomal integrity in cycling vertebrate cells.

  S Takeda; E Sonoda; M Takata; C Morrison; S Tachiiri; Y Yamaguchi-Iwai

  EXPERIMENTAL HEMATOLOGY, Aug. 1998, Peer-reviewed

  
• Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death

  E Sonoda; MS Sasaki; JM Buerstedde; O Bezzubova; A Shinohara; H Ogawa; M Takata; Y Yamaguchi-Iwai; S Takeda

  EMBO JOURNAL, Jan. 1998, Peer-reviewed

  
• A case of dyskeratosis congenita with highly elevated serum IgE

  Minoru Takata; Kiyoshi Takahashi; Ryou Souda; Yasuo Nanba; Kazuo Ogurusu; Arihiko Kanehiro; Hisashi Sugano; Yasushi Tanimoto; Kouichi Yamagata; Noriko Kawada; Ikuro Kimura

  Japanese Journal of Clinical Immunology, 1992, Peer-reviewed

  

Misc.

• ファンコニ貧血の分子機構

  北尾 洋之; 高田 穣

  最新医学, Feb. 2007

  
• RAD18 and RAD54 cooperatively contribute to maintenance of genomic stability in vertebrate cells.

  Sonoda, E; Okada, T; Zhao, G. Y; Tateishi, S; Araki, K; Yamaizumi, M; Yagi, T; Verkaik, N. M; van Gents; D. C; Takata M; Takeda S

  The EMBO Journal, 2002

  
• Synergistic effect of olaparib (AZD2281) with combination of cisplatin on PTEN-deficient lung cancer cell lines

  Daisuke Minami; Nagio Takigawa; Hiromasa Takeda; Minoru Takata; Eiki Ichihara; Akiko Hisamoto; Katsyuyuki Hotta; Masahiro Tabata; Mitsune Tanimoto; Katsuyuki Kiura

  CANCER RESEARCH, Apr. 2012

  
• Chemopreventive effect of gefitinib on tumorgenesis in smoking unrelated lung cancer mouse model

  Kadoaki Ohashi; Katsuyuki Kiura; Masahiro Osawa; Hiromasa Takeda; Toshio Kubo; Eiki Ichihara; Nagio Takigawa; Seiki Hirano; Mitsune Tanimoto; Minoru Takata

  CANCER RESEARCH, May 2008

  
• ファンコニ貧血における相同組み換えの異常

  高田 穣; 山本 和彦; 松下 暢子

  遺伝子医学, Mar. 2003

  
• 高頻度に標的組み換えを起こすニワトリ細胞株を使った生物学・薬学・医学研究への応用

  武田 俊一; 園田 英一朗; 高田 穣; 八木 孝司; 山下 由起子

  日本農芸化学会誌, 05 Mar. 2000

  
• Analysis of homologous DNA recombination in a chicken B cell line, DT40, where targeted integration occurs as frequently as random integration

  TAKEDA S.; SONODA E.; TAKATA M.; IWAI Y.

  Tissue culture research communications : the journal of experimental & applied cell culture research = 組織培養研究, 30 Mar. 1997

  
• P-3 変異型EGFR発現非小細胞肺癌細胞株のRas 12V導入による gefitinib 耐性化(分子生物学1, 第47回日本肺癌学会総会)

  内田 亜希子; 平野 世紀; 北尾 洋之; 荻野 敦子; 頼 冠名; 豊岡 伸一; 瀧川 奈義夫; 田端 雅弘; 高田 穣; 木浦 勝行; 谷本 光音

  肺癌, 05 Nov. 2006

  
• Roles of homologous recombination pathway in vertebrate cells

  YAMAGUCHI-IWAI Yuko; TAKATA Minoru; SONODA Eiichiro; MORRISON Ciaran; TAKEDA Shunichi

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Cisplatin sensitivity of vertebrate cells which lack molecules involved in homologous recombination or non-homologous end-joining pathways

  TAKATA Minoru; TACHIIRI Seiji; FUKUSHIMA Toru; IWAI Yuko; SONODA Eiichiro; MORRISON Ciaran; TAKEDA Shunichi

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• DNA damage response to formaldehyde

  J. Nakamura; A. Nakamura; K. Tano; A. Luke; M. Takata; S. Takeda; M. Watanabe; J. A. Swenberg; J. R. Ridpath

  ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, Aug. 2008

  
• Genetic analysis of DNA repair mechanisms using DT40 cell line

  TAKATA MINORU; MATSUSHITA NOBUKO; KITAO HIROYUKI; HIRANO SEIKI; ISHIAI MASAMICHI

  Tissue culture research communications : the journal of experimental & applied cell culture research = 組織培養研究, 31 Mar. 2006

  
• A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India.

  Donovan FX; Solanki A; Mori M; Chavan N; George M; C SK; Okuno Y; Muramastsu H; Yoshida K; Shimamoto A; Takaori-Kondo A; Yabe H; Ogawa S; Kojima S; Yabe M; Ramanagoudr-Bhojappa R; Smogorzewska A; Mohan S; Rajendran A; Auerbach AD; Takata M; Chandrasekharappa SC; Vundinti BR

  Human mutation, Sep. 2019, Peer-reviewed, Corresponding author

  
• Rapid Acquisition of Alectinib Resistance in ALK-Positive Lung Cancer With High Tumor Mutation Burden.

  Makimoto G; Ohashi K; Tomida S; Nishii K; Matsubara T; Kayatani H; Higo H; Ninomiya K; Sato A; Watanabe H; Kano H; Ninomiya T; Kubo T; Rai K; Ichihara E; Hotta K; Tabata M; Toyooka S; Takata M; Maeda Y; Kiura K

  Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, Jul. 2019, Peer-reviewed

  
• Regulation of R-loops and genome instability in Fanconi anemia.

  Okamoto Y; Hejna J; Takata M

  Journal of biochemistry, Jun. 2019, Peer-reviewed, Last author, Corresponding author

  
• A Prospective Cohort Study to Define the Clinical Features and Outcome of Lung Cancers Harboring HER2 Aberration in Japan (HER2-CS STUDY).

  Ninomiya K; Hata T; Yoshioka H; Ohashi K; Bessho A; Hosokawa S; Ishikawa N; Yamasaki M; Shibayama T; Aoe K; Kozuki T; Harita S; Ueda Y; Murakami T; Fujimoto N; Yanai H; Toyooka S; Takata M; Hotta K; Kiura K; HER2-CS Network

  Chest, May 2019, Peer-reviewed

  
• 複製ストレス応答によるゲノム安定化メカニズム

  勝木 陽子; 高田 穣

  遺伝子医学, 2019, Invited

  
• FANCD2 protects genome stability by recruiting RNA processing enzymes to resolve R-loops during mild replication stress.

  Okamoto Y; Abe M; Itaya A; Tomida J; Ishiai M; Takaori-Kondo A; Taoka M; Isobe T; Takata M

  The FEBS journal, Jan. 2019, Peer-reviewed, Last author, Corresponding author

  Access this misc :

  
• [Genetic analysis of Japanese patients with Fanconi anemia: novel findings].

  Mori M; Yabe H; Yabe M; Takata M

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2019, Peer-reviewed

  
• 日本人ファンコニ貧血患者117人の原因遺伝子と臨床症状の解析(Evaluation of pathogenic variants and clinical characteristics in Japanese Fanconi anemia patients)

  森 美奈子; 平 明日香; 吉田 健一; 村松 秀城; 奥野 友介; 庵前 美智子; 田村 和朗; 安田 純; 大隅 朋生; 野口 靖; 川端 浩; 高折 晃史; 小島 勢二; 小川 誠司; 矢部 普正; 矢部 みはる; 高田 穰

  臨床血液, Sep. 2018

  
• DNAタンパククロスリンク損傷修復におけるFANC及びTDP1遺伝⼦産物の関与

  藤池春奈; Mahmoud SHOULKAMY; Amir SALEM; 笹沼博之; 高田穣; 武田俊一; 増永慎一郎; 井出博; 田野恵三

  第40回日本分子生物学会年会, Dec. 2017, Peer-reviewed

  
• Trastuzumab Emtansine in HER2+Recurrent Metastatic Non-Small-Cell Lung Cancer: Study Protocol

  Kadoaki Ohashi; Katsuyuki Hotta; Taizo Hirata; Keisuke Aoe; Toshiyuki Kozuki; Kiichiro Ninomiya; Hiroe Kayatani; Hiroyuki Yanai; Shinichi Toyooka; Shiro Hinotsu; Minoru Takata; Katsuyuki Kiura

  CLINICAL LUNG CANCER, Jan. 2017, Peer-reviewed

  
• 低グルコースにおいて致死作用をもつメトフォルミンとフェンフォルミンの作用機序の解析

  角田圭; 森脇隆仁; 藤池春奈; 津田雅貴; 笹沼博之; 高田穣; 井出博; 武田俊一; 増永慎一郎; 田野恵三

  日本環境変異原学会第45回大会, Nov. 2016, Peer-reviewed

  
• DT40ノックアウト細胞を用いたBiguanide系薬剤Metforminによるグルコース枯渇下細胞致死作用の解析

  角田圭; 森脇隆仁; 藤池春奈; 津田雅貴; 笹沼博之; 高田穣; 井出博; 武田俊一; 増永慎一郎; 田野恵三

  第39回日本分子生物学会年会, Nov. 2016, Peer-reviewed

  
• DT40ノックアウト細胞パネルを用いたグルコース枯渇下で細胞致死性作用を持つ Biguanide薬剤の作用機序の解析

  角田圭; 森脇隆仁; 藤池春奈; 津田雅貴; 笹沼博之; 高田穣; 武田俊一; 増永慎一郎; 田野恵三

  日本放射線影響学会第59回大会, Oct. 2016, Peer-reviewed

  
• Modularized Functions of the Fanconi Anemia Core Complex (vol 7, pg 1849, 2014)

  Yaling Huang; Justin W. C. Leung; Megan Lowery; Nobuko Matsushita; Yucai Wang; Xi Shen; Do Huong; Minoru Takata; Junjie Chen; Lei Li

  CELL REPORTS, Mar. 2016

  
• Mcm8‐9複合体はRad51依存的鎖潜り込み反応後のDNA伸長反応に関わる

  西村浩平; 夏目豊彰; 石合正道; 深川竜郎; 高田穣; 鐘巻将人

  日本分子生物学会年会プログラム・要旨集(Web), 2013

  
• “DNA 二重鎖切断修復における 相同組換え修復の細胞周期依存性の解析”

  穀田哲也; 勅使河原愛; 長谷川直己; 飯島健太; 高田穣; 小松賢志; 田内広

  第35 回日本分子生物学会年会 2012 年12 月, 2012, Peer-reviewed

  
• “FANCD2 のモノユピキチン化機構の解析”

  佐藤浩一; 石合正道; 高田穣; 胡桃坂仁志

  第35 回日本分子生物学会年会 2012年12月, 2012, Peer-reviewed

  
• “FANCD2 のヒストンシャペロン活性がDNA 修復機能に果たす役 割”

  石合正道; 佐藤浩一; 胡桃坂仁志; 高田穣

  第35回日本分子生物学会年会 ポスターよりワークショップへ採択 2012年12月, 2012, Peer-reviewed

  
• “Mcm8 とMcm9 は複合体を形成し、 DNA 二本鎖架橋修復時に引き起こされる相同組換え修復において働く”

  西村浩平; 石合正道; 堀川一樹; 深川竜郎; 高田穣; 滝澤温彦; 鐘巻将人

  第35 回日本分子生物学会年会 2012 年12 月 ポスターよりワークショップへ採択, 2012, Peer-reviewed

  
• “ファン コニ貧血経路とアルデヒド代謝の遺伝的相互作用解析”

  高田穣; 平明日香; 鈴木直也; 丹羽明; 中畑龍俊; 矢部普正; 斉藤潤; 松尾恵太郎; 矢部みはる

  第35 回日本分子生物学会年会 ポスターよりワーク ショップへ採択 2012年12月, 2012, Peer-reviewed

  
• “DNA 鎖間架橋応答におけるファンコニ貧血経路によるCtIPの調節”

  海野純也; 板谷(内田; 亜希子; 冨田純也; 井倉毅; 田岡万悟; 佐藤浩一; 胡桃坂仁志; 礒辺俊明; 高田穣

  第35 回日本分子生物学会年会 ポスターよりワークショップへ採択 2012 年12 月, 2012

  
• “RecQLS ヘリガーゼのDNA クロスリンク修復における役割”

  細野嘉史; 関政幸; 阿部拓也; 石合正道; 武田俊一; 石井裕; 高田穣; 榎本武美

  第35回日本分子生物学会年会 2012年12月, 2012, Peer-reviewed

  
• The role of SNM1 family nucleases in etoposide-induced apoptosis

  Yoshifumi Hosono; Takuya Abe; Masamichi Ishiai; Minoru Takata; Takemi Enomoto; Masayuki Seki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2011

  
• Mcm8 and Mcm9 from a novel complex involved in resistance to DNA crosslinking agents.

  Kohei Nishimura; Masamichi Ishiai; Tatsuo Fukagawa; Minoru Takata; Haruhiko Takisawa; Masato Kanemaki

  日本分子生物学会第 34 回年会 2011 年12 月 横浜, 2011, Peer-reviewed

  
• Histone chaperone activity of the FANCD2-FANCI complex and its importance in repair interstrand DNA crosslinks by the Fanconi anemia pathway.

  Koichi Sato; Masamichi Ishiai; Kazue Toda; Satoshi Furukoshi; Akihisa Osakabe; Hiroaki Takizawa; Yoshimasa Takizawa; Wataru Kagawa; Hiroyuki Kitao; Naoshi Dohmae; Chikashi Obuse; Hiroshi Kimura; Minoru Takata; Hitoshi Kurumizaka

  日本分子生物学会第34 回年会 2011 年12 月 横浜, 2011, Peer-reviewed

  
• “The Fancni Anemia Core Complex Promotes ATR Signaling”

  J. Tomida; A. itaya; T. Shigechi; J. Unno; E. Uchida; R. Meetei; Y. Maehara; M. Ishiai; M. Takata

  23rd ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM October 2011, Barcelona, Spain, 2011, Peer-reviewed

  
• ATR-ATRIP kinase complex is responsible for triggering of the FA pathway.

  Tomoko Shigechi; Junya Tomida; Koichi Sato; Masahiko Kobayashi; John Eykelenboom; Pessina Fabio; Zhang Yanbin; Emi Uchida; Masamichi Ishiai; Noel Lowndes; Kenichi Yamamoto; Hitoshi Kurumizaka; Yoshihiko Maehara; Minoru Takata

  日本分子生物学会第34 回年会 2011 年12 月 横浜, 2011, Peer-reviewed

  
• 「複製ストレスによるFA 経路の活性化には、ATRIP-ATR キナーゼが必須である」

  茂地智子; 冨田純也; 佐藤浩一; 海野純也; 小林昌彦; 山本健一; 石合正道; 胡桃坂仁志; 前原善彦; 髙田穣

  第70 回日本癌学会学術総会 2011年10月 名古屋, 2011, Peer-reviewed

  
• 「ファンコニ貧血 コア複合体によるATR －ATRIP キナーゼのクロマチン動態制御」

  髙田穣; 冨田純也; 板谷(内田; 亜希子; 茂地智子; 海野純也; 前原善彦; 石合正道

  第70 回日本癌学会学術総会 シンポジウム“Molecular basis of genome instability in cancer” 2011年10月 名古屋, 2011, Peer-reviewed

  
• 「ファンコニ貧血DNA 修復経路の中心タンパク質FANCD2 はヌクレオソームアセンブリー活性を示す」

  石合正道; 佐藤浩一; 髙田穣; 胡桃坂仁志

  第70 回日本癌学会学術総会 2011年10月 名古屋, 2011, Peer-reviewed

  
• 「ファンコニ貧血蛋白質FAN CD2/FANCI 結合タンパク質のプロテオーム解析」

  海野純也; 板谷(内田; 亜希子; 冨田純也; 井倉毅; 高田穣

  第70回日本癌学会学術総会 2011年10月 名古屋, 2011, Peer-reviewed

  
• ATRIP is crutial for activation of the Fanconi anemia pathway through FANCI phosporylation.

  Tomoko Shigechi; Junya Tomida; Emi Uchida; Hiroyuki Kitao; Akiko Itaya; Masamichi Ishiai; Minoru Takata

  International Conference on Radiation and Cancer Biology at Nagasaki 20 ，10 2010 年2 月 長崎市, 2010, Peer-reviewed

  
• 「ファンコニ貧血原因遺伝子産物FANCD2 およびFANCI の複合体形成と機能解 析

  佐藤浩一; 戸田和江; 古越聡; 越坂部晃永; 立和名博昭; 香川亘; 堂前直; 石合正道; 小布施力史; 木村宏; 高田穣; 胡桃坂仁志

  第33 回日本分子生物学会年会 2010 年12 月, 2010, Peer-reviewed

  
• 「DNA ダメージにおけるArtemis の核内動態制御」

  石合正道; 島弘季; 田代聡; 高田穣

  第33 回日本分子生物 学会年会 2010 年12 月, 2010, Peer-reviewed

  
• 「Artemis の核内動態制御機構の解析」

  石合正道; 島弘季; 田代聡; 高田穣

  日本放射線影響学会第53 回大 会 2010 年10 月 ワークショップ, 2010, Peer-reviewed

  
• 「Fanconi 貧血原因遺伝子FANCD2 及びFANCI の機能解析」

  佐藤浩一; 石合正道; 戸田和江; 古越聡; 越坂部晃永; 立和名博昭; 堂前直; 小布施力史; 木村宏; 高田穣; 胡桃坂仁志

  第9 回核ダイナミクス研究会2010 年5 月, 2010, Peer-reviewed

  
• 「DNA 損傷応答ネットワークにおけるリン酸化・ユビキチン化修飾ダイナミクスのプロテオーム解析」

  足立淳; 鳴海良平; 佐野聖三; 久家貴寿; 白水崇; 松本雅記; 中山敬一; 茂木章; 井倉毅; 高田穣; 朝長毅

  第33 回日本分子生物学会年会第83 回「」本生化学会大会合同大会 2010 年12 月, 2010, Peer-reviewed

  
• FANCI phosphorylation by ATR kinase proceeds in a Rad17/TopBP 1 -independent manner.

  Junya Tomida; Akiko Itaya; Emi Uchida; Tomoko shigechi; Masahiko kobayashi; ken-ichi Yamamoto; Masae Ikura; Tsuyoshi ikura; Agata Smogorzewska; Masamichi Ishiai; Minoru Takata

  第33 回日本分子生物学会年会第83 回 日本生化学会大会合同大 会 2010 年12 月 神戸市, 2010, Peer-reviewed

  
• 「DNA損傷応答におけるファンコニ貧血経路の活性化メカニズム」

  冨田純也; 板谷亜希子; 内田恵美; 茂地智子; 井倉正枝; 胡桃坂仁志; 井倉毅; 石合正道; 高田穣

  日本放射線影響学会第53 回大会 2010年10月, 2010, Peer-reviewed

  
• 「DNA ヘリカーゼRECQL5 のDNA 組換え・修復における機能の解析」

  細野嘉史; 阿部卓也; 石合正道; 多田周右; 武田俊一; 高田穣; 関政幸; 榎本武美

  第33 回日本分子生物学会年会 2010 年12 月, 2010, Peer-reviewed

  
• Genomic instability phenotype induced by loss of FancJ helicase function

  Hiroyuki Kitao; Indrajit Nanda; Yoshihiro Kakeji; Yoshihiko Maehara; Minoru Takata

  CANCER RESEARCH, May 2009

  
• A novel role of the FA core complex in FANCI phosphorylation, an important switch in the FA pathway.

  Minoru Takata; Junya Tomida; Tomoko Shigechi; Hiroyuki Kitao; Akiko Itaya; Masamichi Ishiai

  Oral presentation. Twenty-first Annual Fanconi Anemia Research Fund Scientific Symposium (Baltimore USA, Oct 1-4, 2009), 2009, Peer-reviewed

  
• FA NCI リン酸化によるファンコニ貧血コア複合体ユ ビキチンリガーゼの活性化

  冨田純也; 板谷亜希子; 茂地智子; 石合正道; 高田穣

  第32 回日本分子生物学会年会、2009年12月、横浜市, 2009, Peer-reviewed

  
• 細胞周期によるファンコニ貧血経路の活性化制御．「ゲノム不安定 性」

  石合正道; 冨田純也; 板谷亜希子; 高田穣

  第68 回日本癌学会学術総会, 2009, Peer-reviewed

  
• Artemis の動態制御におけるリン酸化の役割

  石合正道; 島弘季; 田代聡; 高田穣

  日本放射線影響学会第52 回大会、2009年11月、広島市, 2009, Peer-reviewed

  
• 「DT40 細胞システムを用いたDNA 損傷応答 研究」

  石合正道; 北尾洋之; 冨田純也; 刀袮重信; 髙田穣

  日本放射線影響学会第51 回大会 2008 年11 月 北九州市, 2008, Peer-reviewed

  
• 「ファンコニ貧血経路の制御とFANCI タンパク質のリン酸化メカニズム」

  冨田純也; 内田亜希子; 北尾洋之; 木下英司; 内田恵美; 小林昌彦; 山本健一; 小池透; 石合正道; 髙田穣

  第31 回日本分子生物学会年会、第81 回日本生化学会大会合同大会 2008 年12 月 神戸市, 2008, Peer-reviewed

  
• 「Ku70 とDNA 依存性蛋白キナーゼは、多くのアポトーシスに必須である」

  刀袮重信; 丹田和恵; 須田泰司; 高田穣; 石合正道

  第31 回日本分子生物学会年会、第81 回日本生化学会大会合同大会 2008 年12 月 神戸市, 2008, Peer-reviewed

  
• 「ヘリカーゼ欠損により生じるゲノム不安定性表現型」

  北尾洋之; ナンタインドラジッド; 木野村愛子; 山添光芳; シュミットマイケル; 武田俊一; 吉永敬士; 前原喜彦; 高田穣

  第67 回日本癌学会学術総会 2008 年10 月 名古屋市, 2008, Peer-reviewed

  
• The epidermal growth factor receptor D761Y mutation and effect of tyrosine kinase inhibitor

  Shinichi Toyooka; Hiroshi Date; Akiko Uchida; Katsuyuki Kiura; Minoru Takata

  CLINICAL CANCER RESEARCH, Jun. 2007

  
• The epidermal growth factor receptor D761Y mutation and effect of tyrosine kinase inhibitor [1]

  Shinichi Toyooka; Hiroshi Date; Akiko Uchida; Katsuyuki Kiura; Minoru Takata

  Clinical Cancer Research, 01 Jun. 2007

  
• Activation of downstream epidermal growth factor receptor (EGFR) signaling provides gefitinib-resistance in cells carrying EGFR mutation

  Akiko Uchida; Seiki Hirano; Hiroyuki Kitao; Atsuko Ogino; Kanmei Rai; Shinichi Toyooka; Nagio Takigawa; Masahiro Tabata; Minoru Takata; Katsuyuki Kiura; Mitsune Tanimoto

  CANCER SCIENCE, Mar. 2007

  
• 「DNA 修復におけるファンコニ貧血経路の新規遺伝子FAAP100 の機能解析」

  石合正道; eidong Wang; 高田穣

  第30 回分子生物学会 第80 回日本生化学会合同大会 2007 年12 月, 2007, Peer-reviewed

  
• 「KU タンパクとDNA 依存性プロテインキナーゼ はDT40 細胞のアポートシスに必須である」

  刀袮重信; 丹田和恵; 湊川洋介; 高田穣; 石合正道

  第30 回分子生物学会 第80 回日本生化学会合同大会 2007 年12 月, 2007, Peer-reviewed

  
• 「FANCI タンパク質のリン酸化とモノユビキチン化による ファンコニ貧血経路の抑制メカニズム」

  高田穣; 石合正道; 木野村愛子; 北尾洋之

  第30 回分子生物学会 第80 回日本生化学会合同大会 ,2007 年12 月, 2007, Peer-reviewed

  
• 「ファンコニ貧血コア複合体によるFANCD2/FANCI 複 合体のモノユビキチン化と相同組換え修復

  高田 穣; 北尾洋之; 木野村愛子; 石合正道

  ワークショップ 放射線DNA 損傷修復機構研究の最前線 放射線影響学会第50 回大会,2007 年11 月, 2007, Peer-reviewed

  
• 「ファンコニ貧血経路の新規因子FAAP100 」

  石合正道; 高田穣

  第66 回日本癌学会学術総会,2007 年10 月, 2007, Peer-reviewed

  
• 「ファンコニ貧血コア複合体によるモノユビキチン化とDNA クロスリンク修復制御」

  高田穣; 北尾洋之; 木野村愛子; 石合正道

  第66 回日本癌学会学術総会,2007 年10 月, 2007, Peer-reviewed

  
• PS-028-6 ゲフィチニブが奏効したBRAF遺伝子変異肺癌の経験(基礎研究2, 第24回日本呼吸器外科学会総会号)

  豊岡 伸一; 青江 基; 佐野 由文; 伊達 洋至; 重松 久之; 内田 亜希子; 宗 淳一; 末久 弘; 小林 成行; 木浦 勝行; 高田 穣; 山根 正修

  日本呼吸器外科学会雑誌, 2007

  
• ニワトリBRCA2の全長クローニング 種を越えて保存された領域/モチーフの解析(Cloning of chicken homologue highlighted conserved domains and motifs in the tumour suppressor gene BRCA2)

  高田 穣; 立入 誠司; 藤森 亮; 三木 義男; 武田 俊一

  日本癌学会総会記事, Sep. 2001

  
• Homologous DNA recombination in vertebrate cells

  E Sonoda; M Takata; YM Yamashita; C Morrison; S Takeda

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2001, Peer-reviewed

  
• Homologous-pairing activity of the human DNA-repair proteins Xrcc3 center dot Rad51C

  H Kurumizaka; S Ikawa; M Nakada; K Eda; W Kagawa; M Takata; S Takeda; S Yokoyama; T Shibata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2001, Peer-reviewed

  
• Antisense oligodeoxynucleotides to latent membrane protein 1 induce growth inhibition, apoptosis and Bcl-2 suppression in Epstein-Barr virus (EBV)-transformed B-lymphoblastoid cells, but not in EBV-positive natural killer cell lymphoma cells

  Toshio Noguchi; Kazuma Ikeda; Kazuhiko Yamamoto; Isao Yoshida; Atsuko Ashiba; Junjiro Tsuchiyama; Katsuji Shinagawa; Tadashi Yoshino; Minoru Takata; Mine Harada

  British Journal of Haematology, 2001

  
• SHP-1/immunoreceptor tyrosine-based inhibition motif-independent inhibitory signalling through murine natural killer cell receptor Ly-49A in a transfected B-cell line

  K Motoda; M Takata; K Kiura; Nakamura, I; M Harada

  IMMUNOLOGY, Jul. 2000

  
• DNA2重鎖切断を制御する遺伝子ノックアウト細胞を用いての細胞周期感受性やRBEの検討

  内海博司; 橋本光正; 田野かおり; 田野恵三; 桜井良憲; 高田穣; 武田俊一

  日本放射線影響学会第41回大会, Dec. 1998, Peer-reviewed

  
• Role of FANCI protein and its phosphorylation for the Fanconi anemia pathway function

  M.Takata; H.Kitao; A.kinomura, A; Smogorzewska; S.J.Elledge; M.Ishiai

  Nineteenth Annual Fanconi Anemia Research Fund Scientific Symposium. Oct 8-11. Chicago., Peer-reviewed

  
• 「リン酸化プロテオミクスを用いた新規DNA 損傷初期応答キナーゼの探索」

  足立淳; 鳴海良平; 佐野聖三; 久家貴寿; 白水 崇; 松本雅記; 中山敬一; 井倉正枝; 井倉 毅; 高田 穣; 朝長毅

  第34 回日本分子生物学会年会, Peer-reviewed

  

Presentations

• Analysis of DNA damage repair by homologous recombination and the Fanconi anemia pathway.

  TAKATA Minoru

  International Particle Medicine Research Symposium IPMRS-2018-Takasaki, 30 Oct. 2018, Invited

  
• Chromosome stress due to endogenous DNA damage and Fanconi anemia

  TAKATA Minoru

  日本血液学会 JSH2018, 13 Oct. 2018, Invited

  
• The ubiquitination pathway that recruits the Fanconi anemia nuclease scaffold SLX4/FANCP.

  Yoko Katsuki; Masako Abe; Haico van Attikum; Yonghwan Kim; Minoru Takata

  Korean Society for Molecular and Cellular Biology. Symposium “Molecular Mechanisms to preserve Genomic Integrity.”, 17 Sep. 2018, Invited

  
• 家族性のがんの話

  髙田 穰

  京都大学 研究連携基盤 丸の内セミナー, 07 Sep. 2018

  
• RNF168 mediates the recruitment of SLX4 via ubiquitination during ICL repair.

  TAKATA Minoru

  2018 IBS CONFERENCE IBS-KSMCB Conference on Genomic Interity &Cell Cycle June, 17 Jun. 2018, Invited

  
• 「ファンコニ貧血経路による染色体ストレス応答制御」 「新規ファンコニ貧血遺伝子RFWD3による相同組換え修復制御メカニズム」

  髙田 穰

  神戸大学 大学院講義＆セミナー 現代の生物学II, 22 Dec. 2017, Invited

  
• Regulation of homologous recombination by a novel FA protein RFWD3/FANCW

  TAKATA Minoru

  National Taiwan University (Invited lecture), 14 Dec. 2017, Invited

  
• DNAタンパククロスリンク損傷修復におけるFANC及びTDP1遺伝子産物の関与

  藤池 春奈; Mahmoud Shoulkamy; Amir Salem; 笹沼 博之; 高田 穣; 武田 俊一; 増永 慎一郎; 井出 博; 田野 恵三

  分子生物学会ConBio2017, 07 Dec. 2017

  
• 核内構造体によるDNA二本鎖切断応答制御機構の解明

  松井 美咲; 木村 祐輔; 安倍 昌子; 石合 正道; 堀 利行; 高田 穰; Stephen Jackson; 西 良太郎

  分子生物学会ConBio2017, 07 Dec. 2017

  
• 核内構造体に局在する因子による相同組換え修復制御

  松井 美咲; 木村 祐輔; 安倍 昌子; 石合 正道; 堀 利行; 高田 穰; Stephen Jackson; 西 良太郎

  ConBio2017, 07 Dec. 2017

  
• 複製ストレスにおける染色体脆弱部位へのR-Loop依存性FANCD2集積メカニズム.

  岡本 裕介; 岩嵜 航; 高橋 数冴; 久郷 和人; 小田 有沙; 河合 秀彦; 佐藤 浩一; 小林 航; 逆井 良; 高折 晃史; 山本 卓; 鐘巻 将人; 田岡 万悟; 磯部 俊明; 胡桃坂 仁志; 印南 秀樹; 太田 邦史; 石合 正道; 高田 穣

  ConBio2017, 07 Dec. 2017

  
• ICL修復因子SLX4はRNF168依存的なユビキチン化経路を介して損傷部位に集積する.

  勝木陽子; 安倍昌子; Haico van Attikum; 中田慎一郎; 鐘巻将人; Yonghwan Kim; 高田穣

  2017年度生命科学系学会合同年次大会ConBio2017, 第40回日本分子生物学会年会ワークショップ, 07 Dec. 2017, Invited

  
• Replication stress induces R-loop-dependent accumulation of FANCD2 at large fragile genes.

  Yusuke Okamoto; Wataru Iwasaki; Kazuto Kugou; Kazue Takahashi; Arisa Oda; Hidehiko Kawai; Koichi Sato; Wataru Kobayashi; Ryo Sakasai; Akifumi Kondo-Takaori; Takashi Yamamoto; Masato T. Kanemaki; Masato Taoka; Toshiaki Isobe; Hitoshi Kurumizaka; Kunihiro Ohta; Hideki Innan; Masamichi Ishiai; Minoru Takata

  Radiation Biology Center International Symposium 2017, 04 Dec. 2017

  
• RNF168 mediates the recruitment of SLX4 via ubiquitination during ICL repair.

  Yoko Katsuki; Masako Abe; Haico van Attikum; Masato Kanemaki; Shinichiro Nakada; Miharu Yabe; Hiromasa Yabe; Yonghwan Kim; Minoru Takata

  3rd DNA Replication/Repair Structures and Cancer Conference., 15 Nov. 2017

  
• Regulation of homologous recombination by a novel FA protein RFWD3/FANCW．

  TAKATA Minoru

  Shenzhen University. 1st International Symposium on Radiation Therapeutics and Biology (isRTB-2017), 31 Oct. 2017

  
• ファンコニ貧血とゲノム損傷修復因子：患者サンプル解析による希少疾患病態解明を目指して

  髙田 穰

  金沢大学薬学シンポジウム2017, 06 Oct. 2017, Invited

  
• ファンコニ貧血の原因遺伝子探索と相同組換えの新規メカニズム

  髙田 穰

  名古屋大学 環境医学研究所 平成29年度 基盤医学特論, 21 Sep. 2017, Invited

  
• Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia.

  Kerstin Knies; Shojiro Inano; María J. Ramírez; Masamichi Ishiai; Jordi Surrallés; Minoru Takata; Detlev Schindler

  29th Annual Fanconi Anemia Scientific Symposium., 14 Sep. 2017

  
• PARI regulates stalled replication fork processing to maintain genome stability upon replication stress in mice．

  Ayako L. Mochizuki; Ami Katanaya; Eri Hayashi; Mihoko Hosokawa; Emiko Moribe; Akira Motegi; Masamichi Ishiai; Minoru Takata; Gen Kondoh; Hitomi Watanabe; Norio Nakatsuji; Shinichiro Chuma

  日本遺伝学会 第89回大会, 13 Sep. 2017

  
• Regulation of homologous recombination by a novel FA protein RFWD3/FANCW.

  Shojiro Inano; Koichi Sato; Yoko Katsuki; Kerstin Knies; Detlev Schindler; Masamichi Ishiai; Hitoshi Kurumizaka; Minoru Takata

  Center for Genomic Integrity at UNIST invited lecture, 27 Jun. 2017, Invited

  
• Regulation of homologous recombination repair by a novel Fanconi anemia E3 ligase RFWD3/FANCW.

  TAKATA Minoru

  6th US-Japan DNA Repair Meeting, 17 May 2017, Invited

  
• Regulation of homologous recombination by a novel FA protein RFWD3.

  Shojiro Inano; Koichi Sato; Yoko Katsuki; Kerstin Knies; Detlev Schindler; Masamichi Ishiai; Hitoshi Kurumizaka; Minoru Takata

  FEBS workshop Nucleotide excision repair and crosslink repair - from molecules to mankind, 07 May 2017, Invited

  
• Pathogenesis of Fanconi anemia: an update.

  TAKATA Minoru

  INTERNATIONAL CONFERENCE ON “ REVOLUTION OF LABORATORY MEDICINE IN MODERN BIOLOGY”, 15 Feb. 2017, Invited

  
• 新規ファンコニ貧血原因遺伝子であるRFWD3/FANCWの相同組換え修復における役割の解明

  髙田 穰

  第8回群馬大 Genome Damage Discussion Group セミナー, 21 Dec. 2016, Invited

  
• Genetic basis for childhood bone marrow failure and malignancies” A novel Fanconi anemia gene regulates ICL repair and homologous recombination.

  TAKATA Minoru

  第58回日本小児血液・がん学会学術集会 シンポジウム, 15 Dec. 2016, Invited

  
• DT40 ノックアウト細胞パネルを用いたグルコース枯渇下で細胞致死性作用を持つBiguanide 薬剤の作用機序の解析

  角田圭; 森脇隆仁; 藤池春奈; 津田雅貴; 笹沼博之; 高田 穣; 武田俊一; 増永慎一郎; 田野恵三

  放射線影響学会第59回大会, 26 Oct. 2016

  
• 損傷応答キナーゼ活性が相同組換え修復に与える影響

  田部井由依; 大橋由佳; 坂本裕貴; 小摩木里奈; 穀田 哲也; 勅使河原愛; 飯島健太; 高田 穣; 小松賢志; 田内 広

  放射線影響学会第59回大会, 26 Oct. 2016

  
• An E3 ligase RFWD3 is a critical component that facilitates RPA and RAD51 dynamics in homologous recombination.

  稲野将二郎; 佐藤浩一; 勝木陽子; 中田慎一郎; 石合正道; 胡桃坂仁志; 高田 穣

  放射線影響学会第59回大会 ワークショップ「放射線・ゲノムストレスに対抗する多彩な生命システムの解明に向けて」, 26 Oct. 2016, Invited

  
• 相同組換えにおけるRPAおよびRAD51の動態制御はRFWD3によるユビキチン化に依存する。

  稲野将二郎; 佐藤浩一; 勝木陽子; 石合正道; 中田慎一郎; 胡桃坂仁志; 高田 穣

  第75回日本癌学会学術総会 シンポジウム18 がんにおける染色体・ゲノム不安定性の分子基盤。, 06 Oct. 2016

  
• Common variable immunodeficiency caused by FANC mutations

  Yujin Sekinaka; Noriko Mitsuiki; Kohsuke Imai; Miharu Yabe; Hiromasa Yabe; Masatoshi Takagi; Ayako Arai; Kenichi Yoshida; Yusuke Okuno; Yuichi Shiraishi; Kenichi Chiba; Hiroko Tanaka; Satoru Miyano; Seiji Kojima; Asuka Hira; Minoru Takata; Osamu Ohara; Seishi Ogawa; Tomohiro Morio; Shigeaki Nonoyama

  ESID2016, 21 Sep. 2016

  
• Myelodysplastic syndrome and acute myeloid leukemia in Japanese Fanconi anemia patients.

  Miharu Yabe; Tsuyoshi Morimoto; Akiko Fukumura; Keisuke Ohtsubo; Takashi Koike; Takashi Shimizu; Hiromitsu Takakura; Katsuyoshi Koh; Etsuro Ito; Seiji Kojima; Asuka Hira; Minoru Takata; Hiromasa Yabe

  28th Annual Fanconi Anemia research frund Scientific Symposium., 15 Sep. 2016

  
• Novel Fanconi anemia E3 ligase RFWD3 promotes removal of both RPA and RAD51 from DNA damage sites during ICL repair.

  Shojiro Inano; Koichi Sato; Kerstin Knies; Yoko Katsuki; Shinichiro Nakada; Akifumi Takaori-Kondo; Masamicih Ishiai; Detlev Schindler; Hitoshi Kurumizaka; Minoru Takata

  28th Annual Fanconi Anemia research frund Scientific Symposium., 15 Sep. 2016

  
• A novel Fanconi anemia E3 ubiquitin ligase RFWD3 functions in DNA repair.

  TAKATA Minoru

  The 32nd International Symposium of Radiation Biology Center, 01 Sep. 2016

  
• Novel Fanconi anemia E3 ligase RFWD3 regulates RPA and RAD51 degradation to facilitate homologous recombination and ICL repair.

  Shojiro Inano; Koichi Sato; Yoko Katsuki; Shinichiro Nakada; Akifumi-Takaori0Kondo; Masamichi Ishiai; Detlev Schindler; Hitoshi Kurumizaka; Minoru Takata

  The 2016 Cold Spring Harbor Asia Conference, 13 Jun. 2016

  
• 新規ファンコニ貧血遺伝子RFWD3による相同組換え修復制御メカニズム

  稲野将二郎; 佐藤浩一; 勝木陽子; 石合正道; 中田慎一郎; 胡桃坂仁志; 高田穣

  九州大学 薬学部 藤田雅俊研究室 研究セミナー, 2016, Invited

  
• 複製ストレスによるFANCD2集積部位のゲノムワイド解析

  石合正道; 岩嵜航; 高橋数冴; 久郷和人; 小田有沙; 大木千夏; 福井哲也; 河合秀彦; 山本卓; 太田邦史; 印南秀樹; 高田穣

  第38回日本分子生物学会年会, 01 Dec. 2015

  
• 相同組換えにおけるＲＰＡ２のユビキチン化を介した分解

  稲野将二郎; 佐藤浩一; 石合正道; 勝木陽子; 中田慎一郎; 胡桃坂仁志; 高田 穣

  第38回日本分子生物学会年会, 01 Dec. 2015

  
• UBE2T/FANCT is a novel FA gene identified in Japanese Fanconi anemia patients.

  Minoru Takata; Asuka Hira; Kenichi Yoshida; Koichi Sato; Akira Shimamoto; Hitoshi Kurumizaka; Seishi Ogawa; Hiromasa Yabe; Miharu Yabe

  16th Ataxia-Teleangiectasia Workshop., 11 Oct. 2015

  
• ファンコニ貧血と遺伝性乳がん卵巣がん：相同組換え欠損を基盤とした高発がん症候群

  髙田 穰

  第74回日本癌学会 学術総会, 08 Oct. 2015, Invited

  
• Perspective in Cancer Biology: Genetic Variations and Host-tumor Interactions. “DNA damage and repair in Fanconi anemia

  TAKATA Minoru

  第２回IFOM−京都大学合同シンポジウム, 06 Oct. 2015, Invited

  
• Genetic subtyping of Fanconi anemia in Japanese patients.

  Miharu Yabe; Hiromasa Yabe; Kenichi Yoshida; Seishi Ogawa; Etsuro Ito; Yusuke Okuno; Hideki Muramatsu; Seiji Kojima; Asuka Hira; Minoru Takata

  27th Annual Fanconi anemia research fund Scientific Symposium., 17 Sep. 2015

  
• Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia.

  A. Hira; K. Yoshida; K.Sato; Y. Shiraishi; K. Chiba; H. Tanaka; S. Miyano; A. Shimamoto; H.Tahara; E.Ito; S.Kojima; H. Kurumizaka; S.Ogawa; M.Takata; H.Yabe; M. Yabe

  27th Annual Fanconi anemia research fund Scientific Symposium., 17 Sep. 2015

  
• The Role of FANCD2 a central player of the Fanconi anemia pathway in DNA repair.

  Masamichi Ishiai; Koishi Sato; Minoru Takata; Hitoshi Kurumizaka

  ICRR2015, 25 May 2015

  
• FANCD2-dependent ATM phosphorylation after incision during DNA interstrand crosslink repair.

  Yoko Katsuki; Minoru Takata

  ICRR2015, 25 May 2015

  
• Identification of UBE2T as a novel Fanconi anemia gene.

  Asuka Hira; Kenichi Yoshida; Koichi Sato; Akita Shimamoto; Hidetoshi Tahara; Hitoshi Kurumizaka; Seishi Ogawa; Minoru Takata; Hiromasa Yabe; Miharu Yabe

  ICRR2015, 25 May 2015

  
• 遺伝性DNA修復異常疾患：家族性乳がんとファンコニ貧血

  髙田 穰

  日本家族性腫瘍学会 第１７回後期家族性腫瘍セミナー, 08 Mar. 2015

  
• DNA鎖間架橋修復で働くFAN1ヌクレアーゼの生化学的機能解析

  平山 恵美子; 高橋 大介; 佐藤 浩一; 高田 穣; 胡桃坂 仁志

  第37回日本分子生物学会年会, 25 Nov. 2014

  
• Fanconi貧血患者にみられるFANCD2変異体の機能解析

  佐藤 浩一; 石合 正道; 高田 穣; 胡桃坂 仁志

  第37回日本分子生物学会年会, 25 Nov. 2014

  
• ゲノム編集酵素によるファンコニ貧血原因遺伝子FANCAのノックアウト細胞作製の試み

  久野 真央; 平 明日香; 高田 穣

  第37回日本分子生物学会年会, 25 Nov. 2014

  
• ファンコニ貧血経路とそのキータンパク質FANCD2の機能解析

  高田 穣; 勝木 陽子; 佐藤 浩一; 石合 正道; 胡桃坂 仁志

  第37回日本分子生物学会年会, 25 Nov. 2014

  
• 日本人ファンコニ貧血患者における新規原因遺伝子UBE2Tの同定

  平 明日香; 吉田 健一; 佐藤 浩一; 嶋本 顕; 田原 栄俊; 胡桃坂 仁志; 小川 誠司; 高田 穣; 矢部 普正; 矢部 みはる

  第37回日本分子生物学会年会, 25 Nov. 2014

  
• UBE2T is a novel FA gene identified in Japanese Fanconi anemia patients

  Minoru Takata; Asuka Hira; Kenichi Yoshida; Koichi Sato; Akira Shimamoto; Hidetoshi Tahara; Hitoshi Kurumizaka; Seishi Ogawa; Hiromasa Yabe; Miharu Yabe

  The 9th 3R Symposium, 17 Nov. 2014

  
• Comprehensive analysis of Japanese Fanconi anemia (FA) patients has led to the identification of an E2 enzyme UBE2T as a novel FA gene.

  TAKATA Minoru

  日米修復会議, 29 Oct. 2014

  
• DNA鎖間架橋除去におけるFAN1ヌクレアーゼの役割

  高橋 大介; 佐藤 浩一; 平山 恵美子; 高田 穣; 胡桃坂 仁志

  第87回日本生化学会大会, 15 Oct. 2014

  
• 相同組換え修復の細胞周期依存性解析

  坂本 裕貴; 大川 沙織; 穀田 哲也; 勅使河原 愛; 飯島 健太; 高田 穣; 小松 賢志; 田内 広

  日本放射線影響学会第５７回大会, 01 Oct. 2014

  
• Infant Japanese Fanconi anemia patients with the ALDH2-AA genotype.

  M. Yabe; A. Hira; H; Yabe; T. Morimoto; A. Fukumura; M. Miyashita; K. Ohtsubo; K. Matsuo; M. Takata

  26th Annual Fanconi Anemia Research Fund Scientific Symposium., 18 Sep. 2014

  
• 遺伝性DNA修復異常疾患：家族性乳がんとファンコニ貧血

  髙田 穰

  第１７回家族性腫瘍セミナー, 24 Aug. 2014

  
• ファンコニ貧血症とDNA修復メカニズム

  髙田 穰

  第３６回日本光医学・光生物学会シンポジウム, 25 Jul. 2014

  
• Roles of the Fanconi anemia protein FANCD2 in DNA cross link repair.

  Masamichi Ishiai; Junya Unno; Koichi Sato; Akiko Itaya; Junya Tomida; Hitoshi Kurumizaka; Minoru Takata

  International Conference, Kyoto, 2014, 04 Feb. 2014

  
• ICL 修復に重要なFAN1ヌクレアーゼの生化学的機能解析

  佐藤 浩一; 高橋 大介; 平山 恵美子; 高田 穣; 胡桃坂 仁志

  日本分子生物学会, 03 Dec. 2013

  
• Mcm8-9 複合体はRad51 依存的鎖潜り込み反応後のDNA 伸長反応に関わる

  西村 浩平; 夏目 豊彰; 石合 正道; 深川 竜郎; 高田 穣; 鐘巻 将人

  分子生物学会ワークショップ, 03 Dec. 2013

  
• ファンコニ貧血原因遺伝子産物FANCD2 の示すヒストンシャペロン活性の生理的意義.

  石合 正道; 佐藤 浩一; 胡桃坂 仁志; 高田 穣

  分子生物学会ワークショップ, 03 Dec. 2013

  
• ゲノム不安定性と発がん

  髙田 穰

  第6回 岡山肺癌治療セミナー, 03 Dec. 2013

  
• Roles of the Fanconi anemia protein FANCD2 in DNA crosslink repair.

  Masamichi Ishiai; Junya Unno; Koichi Sato; Akiko Itaya; Junya Tomida; Hitoshi Kurumizaka; Minoru Takata

  29th RBC-NIRS INTERNATIONAL SYMPOSIUM, 28 Nov. 2013

  
• Fanconi anemia and Bloom syndrome proteins constitute a multifunctional complex to repair DNA damage.

  Zhijiang Yan; Dongyi Xu; David Fox; Jinhu Yin; Rong Guo; Yutong Xue; Ling Chen; Weiping Shen; Yongjiang Li; Amom Ruhikanta Meetei; Minoru Takata; Lei Li; Johan de Winter; Michael Seidman; Weidong Wang

  29th RBC-NIRS INTERNATIONAL SYMPOSIUM, 28 Nov. 2013

  
• ファンコニ貧血-家族性乳がん（FA-BRCA）経路によるゲノム安定性制御

  髙田 穰

  聖マリアンナ医大 講演会, 07 Nov. 2013

  
• ファンコニ貧血とゲノム損傷応答

  髙田 穰

  京都大学 大学病院 血液内科セミナー, 05 Nov. 2013

  
• Pluripotent cell models of Fanconi anemia identify the earliest pathological defect in human hemoangiogenic progenitors.

  N. Suzuki; A. Niwa; M. Yabe; A. Hira; M. Takata; T. Nakahara; M.K. Saito

  25th Annual Fanconi anemia research fund Scientific Symposium, 24 Oct. 2013

  
• Modularized functions of the Fanconi anemia core complex.

  Y.Huang; J.W.C.Leung; M. Lowery; N. Matsushita; Y. Wang; X. Shen; H.G. Do; M. Takata; J. Chen; L. Li

  25th Annual Fanconi anemia research fund Scientific Symposium, 24 Oct. 2013

  
• Involvement of the FA pathway in the maintenance of epigenetic stability near G-quadruplex forming DNA sequences.

  G. Guilbaud; P. Sarkies; M.Takata; K. Patel; J. Sale

  25th Annual Fanconi anemia research fund Scientific Symposium, 24 Oct. 2013

  
• FANCD2 in chromatin anchors CtIP and regulates DNA end resection during crosslink repair.

  J. Unno; A. Itaya; M. Taoka; K. Sato; J. Tomida; W. Sakai; T. Ikura; T. Isobe; H. Kurumizaka; M. Takata

  25th Annual Fanconi anemia research fund Scientific Symposium, 24 Oct. 2013

  
• DNA二重鎖切断修復欠損細胞におけるATM阻害の影響

  坂本裕貴; 深作直子; 阿部紘子; 田中彩; 戸松静香; 大原麻希; 高田 穣; 小松賢志; 立花章; 田内広

  放射線影響学会, 18 Oct. 2013

  
• DNA二本鎖切断修復タンパク質欠損細胞のDNA複製阻害剤感受性

  放射線影響学会, 18 Oct. 2013

  
• 放射線による細胞死研究の新展開」DNA損傷修復関連タンパクによるアポトーシス制御の二面性

  田内広; 大原麻希; 田中 彩; 飯島健太; 高田 穣; 小林純也; 小松賢志

  放射線影響学会, 18 Oct. 2013

  
• Clinical interaction between Japanese Fanconi anemia patients and aldehyde metabolism.

  Miharu Yabe; Asuka Hira; Hiromasa Yane; Kenichi Yoshida; Seishi Ogawa; Seiji Kojima; Minoru Takata

  日本血液学会, 11 Oct. 2013

  
• ファンコニ貧血とＤＮＡクロスリンク修復の分子機構 ー最近の進歩ー

  髙田 穰

  日本血液学会, 11 Oct. 2013

  
• Fanconi anemia and genome instability

  髙田 穰

  京都大学大学院医学研究科 腫瘍コース コロキウム, 29 Sep. 2013

  
• Fanconi貧血とゲノム不安定性

  髙田 穰

  第13回血液フォーラム21 −造血不全− 特別講演, 18 May 2013

  
• Mesodermal progenitors from reprogrammed FA cells were affected by ALDH2 enzymatic activity

  Naoya Suzuki; Asuka Hira; Akira Niwa; Keitaro Matsuo; Minoru Takata; Miharu Yabe; Tatsutoshi Nakahata; Megumu Saito

  ASH highlights in Asia 2013, 24 Mar. 2013

  
• Identification of interactors with the Fanconi anemia proteins FANCD2 using mass spectrometry. Keystone Symposia on Molecular and Cellular Biology, Genomic Instability and DNA Repair (X6).

  Junya Unno; Akiko Itaya; Junya Tomida; Tsuyoshi Ikura; Masato Taoka; Toshiaki Isobe; Minoru Takata

  ザ フェアモント バンフ スプリングス, 13 Mar. 2013

  
• ゲノムへのストレスとの戦い：生命の適応戦略を考える「内なる敵アルデヒドの攻撃からゲノムを守る－「体内浄化」と「傷の修理」の二つの戦略

  髙田 穰

  第33回品川セミナー, Feb. 2013

  
• Pluripotent stem cell model of Seckel syndrome revealed that ATR regulates neural progenitors for orderly brain development.

  Naoya M. Suzuki; Bumpei Samata; Akira Niwa; Toshiyuki Habu; Minoru Takata; Jun Takahashi; Tatsutoshi Nakahata; Mugumu K. Saito

  29th RBC-NIRS INTERNATIONAL SYMPOSIUM, 2013

  
• Biochemical analysis of ICL repair proteins, FANCI-FANCD2 complex.

  Koichi Sato; Daisuke Takahashi; Mayo Shimomuki; Emiko Hirayama; Masamichi Ishiai; Minoru Takata; Hitoshi Kurumizaka

  29th RBC-NIRS INTERNATIONAL SYMPOSIUM, 2013

  
• Effect of ATM kinase inhibitor on radiosensitivity of various DNA double strand break repair deficient cells.

  Yuuki Sakamoto; Naoko Fukasaku; Hiroko Abe; Aya Tanaka; Shizuka Tomatsu; Maki Ohara; Minoru Takata; Kenshi Komatsu; Akira Tachibana; Hiroshi Tauchi

  29th RBC-NIRS INTERNATIONAL SYMPOSIUM, 2013

  
• DNA二重鎖切断修復における相同組換え修復の細胞周期依存性の解析

  穀田哲也; 勅使河原愛; 長谷川直己; 飯島健太; 高田穣; 小松賢志; 田内広

  第35回日本分子生物学会年会, Dec. 2012

  
• RecQL5ヘリカーゼのDNAクロスリンク修復における役割

  細野嘉史; 関政幸; 阿部拓也; 石合正道; 武田俊一; 石井裕; 高田穣; 榎本武美

  第35回日本分子生物学会年会, Dec. 2012

  
• FANCD2のモノユビキチン化機構の解析

  佐藤浩一; 石合正道; 高田穣; 胡桃坂仁志

  第35回日本分子生物学会年会, Dec. 2012

  
• DNA鎖間架橋応答におけるファンコニ貧血経路によるCtIPの調節

  海野純也; 板谷(内田; 亜希子; 冨田純也; 井倉毅; 田岡万悟; 佐藤浩一; 胡桃坂仁志; 礒辺俊明; 高田穣

  第35回日本分子生物学会年会, Dec. 2012

  
• FANCD2のヒストンシャペロン活性がDNA修復機能に果たす役割

  石合正道; 佐藤浩一; 胡桃坂仁志; 高田 穣

  第35回日本分子生物学会年会, Dec. 2012

  
• ファンコニ貧血経路とアルデヒド代謝の遺伝的相互作用解析

  高田穣; 平明日香; 鈴木直也; 丹羽明; 中畑龍俊; 矢部普正; 斉藤潤; 松尾恵太郎; 矢部 みはる

  第35回日本分子生物学会年会, Dec. 2012

  
• Mcm8とMcm9は複合体を形成し、DNA二本鎖架橋修復時に引き起こされる相同組換え修復において働く

  西村浩平; 石合正道; 堀川一樹; 深川竜郎; 高田穣; 滝澤温彦; 鐘巻将人

  第35回日本分子生物学会年会, Dec. 2012

  
• DNA損傷シグナルとファンコニ貧血経路

  髙田 穰

  生体調節研究所セミナー講演, 15 Nov. 2012

  
• Histone chaperon activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair

  Masamichi Ishiai; Koichi Sato; Kazue Toda; Satoshi Furukoshi; Akihisa Osakabe; Hiroaki Tachiwana; Yoshimasa Takizawa; Wataru Kagawa; Hiroyuki Kitao; Naoshi Dohmae; Chikashi Obuse; Hiroshi Kimura; Minoru Takata; Hitoshi Kurumizaka

  The 8th 3R Symposium, Nov. 2012

  
• Molecular pathogenesis of Fanconi anemia

  TAKATA Minoru

  Nov. 2012

  
• Genetic interplay between the Fanconi anemia pathway and aldehyde metabolism in humans

  Minoru Takata; Asuka Hira; Naoya Suzuki; Akira Niwa; Tatsutoshi Nakahata; Hiromasa Yabe; Megumu K. Saito; Keitaro Matsuo; Miharu Yabe

  The 8th 3R Symposium, Nov. 2012

  
• Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients

  Asuka Hira; Naoya Suzuki; Akira Niwa; Tatsutoshi Nakahata; Megumu Saito; Hiromasa Yabe; Keitaro Matsuo; Minoru Takata; Miharu Yabe

  1st IFOM-KU joint symposium, 25 Oct. 2012

  
• Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.

  K. Nishimura. M.Ishiai; K. Horikawa; T.Fukagawa; M. Takata; H.Takisawa; M. Kanemaki

  24th ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM, 27 Sep. 2012

  
• FANCG functions independently of FANCA in the D1-D2-X3-Rad51C complex: Evidence for incomplete epistasis of FANCG/A

  F.Makki; J.B. Wilson; H.J. van; der Vrugt; Y.Xhiao; A. Aladwani; M. Takata; G.M. Kupfer; N.J. Jones

  24th ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM, 27 Sep. 2012

  
• Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients

  Asuka Hira; Hiromasa Yabe; Keitaro Matsuo; Minoru Takata; Miharu Yabe

  24th ANNUAL Fanconi Anemia Research Fund SCIENTIFIC SYMPOSIUM, 27 Sep. 2012

  
• ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity

  Hiroyuki Kitao; Ysohihiko Fujinaka; Kauaki Matsuoka; Makoto Iimori; Munkhbold Tuul; Ken-ichi Yamamoto; Minoru Takata; Eiji Oki; Yoshihiro Kakeji; Yoshihiko Maehara

  第71回日本癌学会学術総会, Sep. 2012

  
• Discovery of early-response kinases in DNA-damagesignaling using phosphoproteome analysis

  Jun Adachi; Taakahisa Kuga; Takashi Shiromizu; Hideaki Kume; Satoshi Murakami; Keiichi Nakayama; Tsuyoshi Ikura; Minoru Takata; Takeshi Tomonaga

  第71回日本癌学会学術総会, Sep. 2012

  
• Histone chaperone activity of FANCD2 plays an important role in the Fanconi anemia pathway

  Koichi Sato; Masamichi Ishiai; Minoru Takata; Hitoshi Kurumizka

  第71回日本癌学会学術総会, Sep. 2012

  
• Genetic interplay between Fanconi anemia and aldehyde metabolism in humans

  Minoru Takata; Asuka Hira; Hiromasa Yabe; Keitaro Matsuo; Miharu Yabe

  第71回日本癌学会学術総会, Sep. 2012

  
• Crosstalk signaling between checkpoint and the Fanconi anemia DNA repair pathway

  Junya Unno; Junya Tomida; Tomoko Shigechi; Akiko Itaya; Minoru Takata

  第71回日本癌学会学術総会, Sep. 2012

  
• New horizons of chromosome dynamics study

  日本分子生物学会 第３２回年会, 09 Dec. 2009

  
• Analysis of the activation mechanism of the Fanconi anemia pathway．

  日本分子生物学会 第３２回年会, 09 Dec. 2009

  
• DNA damage signaling in the Fanconi anemia pathogenesis

  第５１回 小児血液学会 血液プレジデンシャルシンポジウム「DNA damage response and hematological disorder」, 29 Nov. 2009

  
• REGULATION OF CROSS-LINK REPAIR THROUGH THE FANCONI ANEMIA PATHWAY.

  The Fortieth International Symposium of the Princess Takamatsu Cancer Research Fund, 10 Nov. 2009

  
• 高発がん遺伝病ファンコニ貧血の分子メカニズム

  第71回 日本血液学会学術集会 シンポジウム「小児血液腫瘍の発症リスクと先天異常」, 23 Oct. 2009

  
• Monoubiquitination- and phosphorylation-dependent activation of the Fanconi anemia pathway.

  The 3rd International Open Laboratory Workshop, “Recent Development in DNA Repair Studies”, 27 Feb. 2009, 放射線医学総合研究所

  
• ファンコニ貧血経路によるゲノム安定化メカニズム

  第３回放射線防護研究センターシンポジウム「生き物はどのようにして放射線に立ち向かうか－DNA損傷応答と適応応答－」, 16 Dec. 2008, 放射線総合医学研究所

  
• DNA repair network deficiency and carcinogenesis

  第67回日本癌学会学術総会, 28 Oct. 2008, 日本癌学会

  
• ゲノムの安定性維持メカニズムとファンコニ貧血

  第101回 小児血液腫瘍懇話会, 18 Jul. 2008

  

Books and Other Publications

• 先天性骨髄不全症 診療ガイドライン

  矢部普正; 高田穣; 村松秀樹, Joint work, III Fanconi貧血

  診断と治療社, Oct. 2017, Not refereed

  
• 放射線医科学の事典

  石合正道; 高田 穣, Joint work, 2.18 放射線応答遺伝子の生物種間の保存・相関

  医療科学社, Nov. 2016, Not refereed

  
• ゲノムを司るインターメア 非コードDNAの新たな展開

  髙田 穰, Joint work, １１章 「ゲノム脆弱部位の維持と機能」

  化学同人, Nov. 2015, Not refereed

  
• 家族性腫瘍学 —家族性腫瘍の最新研究動向—増刊号6

  稲野将二郎; 平明日香; 高田 穣, II.各論 原因遺伝子 Fanconi anemia 経路によるDNA鎖間結合の修復メカニズム 305−310頁

  日本臨床社, Aug. 2015, Not refereed

  
• DNA Replication, Recombination, and Repair.

  Masamichi Ishiai; Junya Tomida; Akiko Itaya; James Hejna; Minoru Takata, Joint work, The Fanconi Anemia Pathway and Interstrand Cross-Link Repair. pp 175-210

  Springer, 2015, Not refereed

  
• Methods Mol Biol.

  Ishiai M; Uchida E; Takata M, Joint work, Establishment of the DNA repair-defective mutants in DT40 cells. pp39-49

  springer, 2012, Not refereed

  

Awards

• 2009

  公益信託　日本白血病研究基金, 日本白血病研究基金　荻村孝特別研究賞
• Sep. 2015

  Fanconi anemia Research Fund, Fanconi anemia Research Fund Discovery Award
• Sep. 2017

  Fanconi anemia Research Fund, Fanconi anemia Research Fund Discovery Award

External funds: Kakenhi

• Genome-stabilizing activity of aldehyde catalyzing enzymes that support epigenetic reprogramming

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  Minoru Takata

  From 30 Jul. 2020, To 31 Mar. 2024, Project Closed

  DNA 損傷;ホルムアルデヒド;エピゲネティック再構築;iPS 細胞;ADH5;ALDH2;Fanconi anemia;iPS cells;reprogramming;脱メチル化;ADD症候群;ADD syndrome;エピゲノム再構成;フォルムアルデヒド;ゲノム損傷;iPS細胞;リプログラミング;アルデヒド;エピジェネティックリプログラミング;脱メチル化酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21394/
• The role of SLFN11 gene that determines DNA damage sensitivity at the stalled replication forks

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49010:Pathological biochemistry-related

  Kyoto University

  Minoru Takata

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  SLFN11;複製ストレス;複製フォーク;RAD51;DNA2;MRE11;癌化学療法;DNAファイバー法;SLFNファミリー;ファンコニ貧血;複製フォーク分解;FANCD2;複製フォーク停止;DNA損傷

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03450/
• Hunting and analysis of novel genes causing Fanconi anemia

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Minoru Takata

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  ファンコニ貧血;FA経路;RFWD3;ユビキチン化;原因遺伝子;DNA損傷修復;相同組換え;ゼブラフィッシュ;ゲノムシーケンス;DNA修復;モノユビキチン化;次世代シーケンサー;アレイCGH;先天性骨髄不全

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H01738/
• Analysis of tissue-specific distribution and function of ALDH isoforms in Fanconi anemia pathway

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Minoru Takata

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  アルデヒド;ALDH;ファンコニ貧血;ALDH2;ADH5;内因性アルデヒド;再生不良性貧血;DNA修復;ＡＬＤＨ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26550026/
• Regulatory mechanisms of CtIP nuclease during DNA crosslink repair

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Minoru TAKATA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  Fanconi貧血;FANCD2;CtIP;ユビキチン化;DNAクロスリンク損傷;DNA損傷修復;ファンコニ貧血;end resection;クロスリンク修復;モノユビキチン化;Fanconi anemia;DNA損傷応答;DNA修復;チェックポイント

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24310042/
• A basic studyon malignant mesothelioma pathogenesis by internal radiation exposure of radium contained in the iron-containing protein

  Grant-in-Aid for Challenging Exploratory Research

  Okayama University

  Katsuyuki KIURA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  非閉塞性肺疾患癌;悪性中皮腫;ラジウム;生体内被曝;鉄;発癌;プリミティブマントル正規化微量原素パターン;ラット;含鉄蛋白;体内被曝;(1)含鉄蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659432/
• Regulation of protein expression using a cell cyclce-specific degron and its application to functional analysis

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Minoru TAKATA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  DNA修復;DNA損傷チェックポイント;Treslin;Geminin;Cdt1;細胞周期特異的デグロン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23651046/
• Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

  Grant-in-Aid for Scientific Research (B)

  Okayama University

  Katsuyuki KIURA

  From 01 Apr. 2011, To 31 Mar. 2015, Project Closed

  EGFR遺伝子改変マウス;afatinib;everolimus (mTOR阻害薬),;JAK-1/2 inhibitors;cetuximab;bevacizumab;Ogg1ホモノックアウトマウス;NNK;EGFR;everolims;AZD1480;gefitinib;用量依存性;遺伝子改変マウス;ｍTOR阻害薬;everolimus;JAK1/2阻害薬;BIBW2552;mTOR阻害薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390221/
• Analysis of disorders defective in the mechanisms for fork stabilization

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Takata Minoru

  From 01 Apr. 2011, To 31 Mar. 2016, Project Closed

  複製ストレス;ゲノム安定性;ファンコニ貧血経路;チェックポイント;DNA複製;相同組換え;複製フォーク;FANCD2;染色体脆弱部位;ファンコニ貧血;非コードDNA;DNA複製フォーク;染色体ストレス;クロマチン;ATRIP-ATR

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23114010/
• The function of non-coding DNA for genome integrity

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The University of Tokyo;National Institute of Genetics

  Takehiko Kobayashi

  From 01 Apr. 2011, To 31 Mar. 2016, Project Closed

  非コードDNA;インターメア;ゲノム;染色体;ゲノムの安定性;テロメア;クロマチン;セントロメア;非コードDNA領域;クロマチン構造;反復配列;クロマチンネットワーク;非コード機能配列;連携研究;細胞老化;組換え;出芽酵母;リボソームRNA遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-23114001/
• Regulation of the ubiquitin system by checkpoint kinases in response to stalled replication forks

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Minoru TAKATA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  ファンコニ貧血;チェックポイントキナーゼ;リン酸化;モノユビキチン化;FANCD2;FANC1;FANCL;FANCI;コア複合体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390094/
• ファンコニ貧血経路の真のターゲットは内因性ホルマリンによる蛋白質ゲノム架橋か?

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  高田 穣

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  ファンコニ貧血;メダカ;BRCA2;家族性乳がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20651014/
• Chemoprevention of Lung Cancer using Epidermal Growth Factor Receptor Transgenic Mice

  Grant-in-Aid for Scientific Research (C)

  Okayama University

  Katsuyuki KIURA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  肺癌;腺癌;非喫煙者;化学予防;遺伝子改変マウス;上皮成長因子受容体;ゲフィチニブ;バンデタニブ;肺腺癌;血管内皮細胞成長因子受容体;分子標的化学予防;ZD6474;非喫煙;EGFR;SP-C

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19590895/
• Regulation of the ubiquitin system by checkpoint kinases in response to stalled replication forks

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Minoru TAKATA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  ファンコニ貧血;チェックポイントキナーゼ;リン酸化;モノユビキチン化;DNA修復;チェックポイント;ユビキチン化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390087/
• Induction of single DNA double strand break in animal cell genome and its monitoring methodology

  Grant-in-Aid for Scientific Research (C)

  HIROSHIMA UNIVERSITY;Kawasaki Medical School

  Minoru TAKATA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  DNA連鎖切断修復;TAT配列;エストロジェン受容体;DNA二重鎖切断修復;I-SceI, DNA double strand break;DNA repair;I-SceI;homologous recombination;non-homologous end joining;estrogen receptor;tamoxifen

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17590279/
• Functional analysis of Fanconi anemia genes that are involved in chromosomal stability and tumor prevention

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;Hiroshima University;Kawasaki Medical School

  Minoru TAKATA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  ファンコニ貧血;ゲノム不安定性;FANCD2;FANCI;ユビキチン化;DNA修復;シスプラチン;モノユビキチン化;ゲノム安定性;FAコア複合体;DT40細胞;相同DNA組み換え

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17013083/
• Physical monitoring of repair process of chromosomal double stand break induced by simultaneous nuclear introduction of I-SceI endonuclease

  Grant-in-Aid for Scientific Research (C)

  Kawasaki Medical School

  Minoru TAKATA

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  DNA二重鎖切断;DNA修復;I-Scel;TAT配;エストロジェン受容体;I-SceI;TAT配列;プロテイントランスダクション;I-Sce I, DNA double strand break;DNA repair;estrogen receptor;protein transduction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590259/
• Analysis of genetic interactions of DNA repair pathways

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Shunichi TAKEDA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  DNA損傷;複製;損傷乗り越え;相同DNA組換え;DNAポリメラーゼ;DT40;姉妹染色分体交換;相同DNA組み換え;DNA修復;チェックポイント;DT40細胞;遺伝子治療, DNA damage;DNA replication;Translesion DNA synthesis;Homologous DNA recombinatior;DNA polymerase;DT40;Sister chromatid exchange

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13480228/
• NK細胞白血病/リンパ腫の増殖機序と増殖抑制に関する研究

  Grant-in-Aid for Exploratory Research

  Kyushu University;Okayama University

  原田 実根

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  NK細胞リンパ腫;鼻腔原発;エプスタイン・バーウィルス(EBV);latent membrane protein1;アポトーシス;薬剤耐性;P糖蛋白;NKリンパ種;Epstein-Barr virus(EBV);NK細胞;LMP-1;Bcl-2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12877159/
• 家族性乳癌原因遺伝子Brca2の欠損細胞株作成によるBrca2の機能解析-乳癌由来変異Brca2分子の機能評価システムの構築-

  Grant-in-Aid for Exploratory Research

  Kawasaki Medical School

  高田 穣

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  BRCA2;相同DNA組み換え;家族性乳ガン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12877026/
• Development of new assays to evaluate cellular effects of jonizing radiation

  Grant-in-Aid for Scientific Research (B)

  KAWASAKI MEDICAL SCHOOL

  Minoru TAKATA

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  電離放射線;DNA修復;染色体;LOH;相同DNA組み換え;Rad51;Rad52;XRCC3, ionizing radiation;DNA repair;Chromosome;LOH

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12480155/
• Functional analysis of genes involved in maintenance of chromosome stability and homologous recombination

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kawasaki Medical School

  Minoru TAKATA

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  DNA修復;相同DNA組み換え;DT40細胞;Rad51パラログ;ファンコニ貧血;BLMヘリケース;姉妹染色分体交換;相同組替え;ジーンターゲティング;複製後修復;相同組み換え;Rad51;Rad51ファミリー;Rad52;XRCC3, homologous recombination;DNA repair;DT 40 cells;Rad51 paralogs;Fanconi anemia;sister chromatid exchanges

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12213059/
• ヒト癌細胞シスプラチン感受性決定因子としてのDNA損傷修復分子機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  高田 穣

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  DNA相同組換え;Rad51;ジーンターゲティング;ヌクレオチド除去修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11140234/
• 遺伝子ターゲッティングの組換え頻度の調節機構の解析-次世代の遺伝子治療への基礎的アプローチ-

  Grant-in-Aid for Exploratory Research

  Kyoto University

  園田 英一朗

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  遺伝子相同組み換え;DT40細胞;Rad51;Rad52;Rad54;DNA修復;染色体不安定性;姉妹染色分体交換

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10878117/
• Reverse Genetic Analysis of Homologous DNA Recombination in Higher Eukaryotes

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Shunichi TAKEDA

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  DNA相同組換え;Rad51;DT40;DNA修復;ジーンターゲティング;ヌクレオチド除去修復;相同DNA組換え;標的組換え;ターゲットインテグレーション;放射線;染色体断裂, Homologous DNA recombination;Rad 51;DT40;DNA repair

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10480192/
• 高頻度にターゲットインテグレーションを起すニワトリ細胞株の相同組換え機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  武田 俊一

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  相同DNA組換え;標的組換え;DT40;ターゲットインテグレーション;Rad51;DNA修復;放射線;染色体断裂

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10168212/
• ヒト癌細胞のシスプラチン感受性決定因子としての相同組み換え関連遺伝子群の役割-ノックアウト細胞株と肺癌細胞株による検討-

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  高田 穣

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  シスプラチン;Rad51関連遺伝子群;ジーンターゲティング;肺ガン細胞株;相同DNA組み換え機構

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10153229/
• 高頻度にターゲットインテグレーションをおこすニワトリ細胞株の相同組換え機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  武田 俊一

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  相同DNA組換え;標的組換え;DT40;ターゲットインテグレーション;Rad51;DNA修復;放射線;染色体断裂

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10152227/
• Analysis of homologous DNA recombination using the chicken B-lymphocyte line

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY

  Shunichi TAKEDA

  From 01 Apr. 1998, To 31 Mar. 2001, Project Closed

  DT40;発がん;DNA修復;癌治療;チェックポイント;放射線;相同DNA組み換え;DNA相同組換え;Rad51;ジーンターゲティング;ヌクレオチド除去修復;標的組み換え;ターゲットインテグレーション;遺伝子ノックアウト;電離放射線;Ku, DT40;fumorigenesis;DNA repair;checkpoint;chemothrapy of cancer;homologous DNA recombination;ionizing radiation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10044274/
• 遺伝子ターゲッティングの組換え頻度を調節する分子同定の試み:次世代の遺伝子治療への基礎的アプローチ

  Grant-in-Aid for Exploratory Research

  Kyoto University

  園田 英一朗

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  Rad51;DNA修復;相同組換え;誘導型ノックアウト;DT40細胞;染色体異常

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09878152/
• MHCクラスIとクラスIIの両方の分子を認識できるT細胞のT細胞抗原受容体の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  武田 俊一

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  キラーT細胞;MHC拘束性;T細胞抗原受容体;組織適合抗原;アロ抗原;胸腺における選択

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09271214/
• ニワトリBリンパ細胞株での、RAD遺伝子群の、DNA組換えと、修復機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  武田 俊一

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  DT40;相同組み換え;Rad51;組み換え修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09269211/
• RAD54変異ニワトリBリンパ細胞株の、DNA複製中に起ったDNA損傷の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  武田 俊一

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  DT40;相同組み換え;組み換え修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09254229/
• 染色体安定性の癌化への関わり(DT40細胞を用いた試み)

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  岩井 裕子

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  染色体不安定性;相同DNA組換え;RAD51;RAD52;RAD54;DT40細胞;DNA2重鎖切断;修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09253226/
• 高頻度ターゲットインテグレーションをおこす鶏細胞株での相同組換え機構の解析

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  武田 俊一

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  相同DNA組換え;Rad51;Ku;遺伝子治療;DT40;遺伝子ノックアウト;Rad52;Rad54

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670146/

External funds: others

• 遺伝性骨髄不全症の登録システムの構築と診断基準・重症度分類・診断ガイドラインの確率に関する研究 (2024年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2024, To 31 Mar. 2025

  研究分担者
• 難治性疾患政策研究事業 (2022年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  研究分担者
• 先天性骨髄不全症の登録システムの構築と診断基準・重症度分類・診断ガイドラインの確立に関する研究 (2021年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  分担
• ファンコニ貧血新規原因遺伝子の同定と解析への共同研究 （平成27年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2015, To 31 Mar. 2016

  高田　穰
• ファンコニ貧血新規原因遺伝子の同定と解析への共同研究 （平成28年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2016, To 31 Mar. 2017

  高田　穰
• （2020度分）

  先天性骨髄不全症の登録システムの構築と診断基準・重症度分類・診断ガイドラインの確立に関する研究

  From 01 Apr. 2020, To 31 Mar. 2021

  分担
• 乳がん易罹患性の診断とそれに基づく予防に関する研究

  厚生労働省がん研究助成金

  From 2007, To 2007

  分担
• ファンコニ貧血とその類縁疾患の生体試料収集に関する研究

  厚生労働科学研究費補助金

  From 2009, To 2009

  分担
• 稀少小児遺伝性血液疾患の迅速な原因究明及び診断・治療法の開発に関する研究

  厚生労働科学研究費補助金

  From 2011, To 2013

  分担
• 発がん防御におけるクロマチン制御因子の役割

  受託研究・原子力安全研究推進事業

  From 2010, To 2015

  分担
• （2019年度分）

  難治性疾患政策研究事業

  From 01 Apr. 2019, To 31 Mar. 2020

  分担
• 平成28年度分

  難治性疾患等政策研究事業（難治性疾患政策研究事業）

  From 01 Apr. 2016, To 31 Mar. 2017

  分担
• （平成27年度分）

  難治性疾患等政策研究事業（難治性疾患政策研究事業）

  From 01 Apr. 2015, To 31 Mar. 2016

  分担
• （平成29年度分）

  難治性疾患等政策研究事業（難治性疾患政策研究事業）

  From 01 Apr. 2017, To 31 Mar. 2018

  分担
• （平成30年度分）

  難治性疾患等政策研究事業（難治性疾患政策研究事業）

  From 01 Apr. 2018, To 31 Mar. 2019

  分担

Education

Teaching subject(s)

• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course in Chromosome Researches

  1027, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Environmental Molecular Life Science 2

  L017, Fall, Graduate School of Human and Environmental Studies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Studies on interdisciplinary environment II

  3002, Year-long, Graduate School of Human and Environmental Studies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Seminar I in Environmental Molecular Life Sciences

  Q007, Spring, Graduate School of Human and Environmental Studies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Environmental Molecular Life Science 1

  L016, Spring, Graduate School of Human and Environmental Studies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Special Seminar in Molecular Studies on Chemical and Biological Environments

  Q018, Year-long, Graduate School of Human and Environmental Studies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Studies on interdisciplinary environment I

  3001, Year-long, Graduate School of Human and Environmental Studies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Seminar II in Environmental Molecular Life Sciences

  Q008, Fall, Graduate School of Human and Environmental Studies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Special Studies on Interdisciplinary environment I

  Q001, Year-long, Graduate School of Human and Environmental Studies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  DNA Damage Signaling

  L019, Spring, Graduate School of Human and Environmental Studies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Special Studies on Interdisciplinary environment II

  Q002, Year-long, Graduate School of Human and Environmental Studies, 2
• From Apr. 2011, To Mar. 2012

  Life and Radiation

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Radiation Biology and Medicine

  Spring, 工学研究科
• From Apr. 2012, To Mar. 2013

  Life and Radiation

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Life and Radiation

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Radiation Biology and Medicine

  Spring, 工学研究科
• From Apr. 2014, To Mar. 2015

  Life and Radiation

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Special Seminar in Molecular Studies on Chemical and Biological Environments

  Year-long, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  DNA Damage Signaling

  Spring, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Life and Radiation

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Seminar in Environmental Molecular Life Science 1

  Spring, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Seminar in Environmental Molecular Life Science 2

  Fall, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Seminar II in Environmental Molecular Life Sciences

  Fall, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Seminar I in Environmental Molecular Life Sciences

  Spring, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2015, To Mar. 2016

  Special Studies on Interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Special Studies on Interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Studies on interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2015, To Mar. 2016

  Studies on interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Special Seminar in Molecular Studies on Chemical and Biological Environments

  Year-long, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  DNA Damage Signaling

  Spring, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Radiation Biology and Medicine

  Spring, 工学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Environmental Molecular Life Science 1

  Spring, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Environmental Molecular Life Science 2

  Fall, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Seminar II in Environmental Molecular Life Sciences

  Fall, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Seminar I in Environmental Molecular Life Sciences

  Spring, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Special Studies on Interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Special Studies on Interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Studies on interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Studies on interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Special Seminar in Molecular Studies on Chemical and Biological Environments

  Year-long, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  DNA Damage Signaling

  Spring, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Environmental Molecular Life Science 1

  Spring, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Environmental Molecular Life Science 2

  Fall, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Seminar II in Environmental Molecular Life Sciences

  Fall, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Seminar I in Environmental Molecular Life Sciences

  Spring, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2017, To Mar. 2018

  Special Studies on Interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Special Studies on Interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Studies on interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Studies on interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Special Seminar in Molecular Studies on Chemical and Biological Environments

  Year-long, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  DNA Damage Signaling

  Spring, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Seminar in Environmental Molecular Life Science 1

  Spring, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Seminar in Environmental Molecular Life Science 2

  Fall, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Seminar II in Environmental Molecular Life Sciences

  Fall, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Seminar I in Environmental Molecular Life Sciences

  Spring, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2018, To Mar. 2019

  Special Studies on Interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Special Studies on Interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Studies on interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Studies on interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Special Seminar in Molecular Studies on Chemical and Biological Environments

  Year-long, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  DNA Damage Signaling

  Spring, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Course in Chromosome Researches

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Seminar in Environmental Molecular Life Science 1

  Spring, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Seminar in Environmental Molecular Life Science 2

  Fall, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Seminar II in Environmental Molecular Life Sciences

  Fall, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Seminar I in Environmental Molecular Life Sciences

  Spring, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2019, To Mar. 2020

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Special Studies on Interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Special Studies on Interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Studies on interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Studies on interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  ILAS Seminar :Why we get cancer, and how we tackle it.

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Special Seminar in Molecular Studies on Chemical and Biological Enviroments

  Year-long, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  DNA Damage Signaling

  Spring, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Seminar in Environmental Molecular Life Science 1

  Spring, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Seminar in Environmental Molecular Life Science 2

  Fall, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Seminar II in Environmental Molecular Life Sciences

  Fall, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Seminar I in Environmental Molecular Life Sciences

  Spring, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2020, To Mar. 2021

  Special Studies on Interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Special Studies on Interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Studies on interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2020, To Mar. 2021

  Studies on interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  ILAS Seminar :Why we get cancer, and how we cope with it?

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Special Seminar in Molecular Studies on Chemical and Biological Enviroments

  Year-long, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  DNA Damage Signaling

  Spring, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Seminar in Environmental Molecular Life Science 1

  Spring, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Seminar in Environmental Molecular Life Science 2

  Fall, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Seminar II in Environmental Molecular Life Sciences

  Fall, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Seminar I in Environmental Molecular Life Sciences

  Spring, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Special Studies on Interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Special Studies on Interdisciplinary environment I

  Year-long, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Studies on interdisciplinary environment II

  Year-long, 人間・環境学研究科
• From Apr. 2021, To Mar. 2022

  Studies on interdisciplinary environment I

  Year-long, 人間・環境学研究科

Participation in PhD Defense

• ヒト正常細胞における低線量放射線のミトコンドリアおよび微小核誘導に及ぼす影響の解明

  MENG QINGMEI, Graduate School of Human and Environmental Studies, Sub-chief Examiner

  24 Nov. 2021
• リボソームDNAおよびサブテロメアにおける 繰り返し配列維持に係る分裂酵母Stn1の機能

  YAMAMOTO IO, Graduate School of Biostudies, Sub-chief Examiner

  24 Nov. 2021

Administration

School management (title, position)

• From 01 Apr. 2008, To 31 Mar. 2011

  京都大学ヒトゲノム・遺伝子解析研究管理委員会 委員
• From 11 Sep. 2011, To 10 Sep. 2013

  京都大学ヒトゲノム・遺伝子解析研究管理委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2015

  全学情報セキュリティ委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2015

  大学評価委員会 委員
• From 05 Feb. 2014, To 31 Mar. 2015

  吉田寮整備委員会委員
• From 11 Sep. 2013, To 10 Sep. 2015

  ヒトゲノム・遺伝子解析研究管理委員会 委員
• From 01 Apr. 2013

  大学評価委員会点検・評価実行委員会 委員
• From 01 Apr. 2015

  全学情報セキュリティ委員会 委員
• From 11 Sep. 2015, To 31 Dec. 2015

  ヒトゲノム・遺伝子解析研究管理委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  全学情報セキュリティ委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2018

  放射線生物研究センター長
• From 01 Apr. 2018, To 31 Mar. 2019

  放射線生物研究センター長
• From 01 Apr. 2018, To 31 Mar. 2023

  放射性同位元素等専門委員会委員