Basic Information

Faculty

• Faculty of Engineering

Academic Degree

• 修士（工学）(京都大学)
• 博士（工学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院工学研究科修士課程合成･生物化学専攻, 修了
• 京都大学, 大学院工学研究科博士後期課程合成･生物化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 工学部工業化学科, 卒業

High School

• High School

  立教新座高等学校

Research History

• From Jan. 2023, To Present

  Kyoto University, Graduate School of Engineering Department of Synthetic Chemistry and Biological Chemistry, 准教授
• From Apr. 2019, To Dec. 2022

  Kyoto University, 白眉センター, 特定准教授
• From Jun. 2015, To Mar. 2019

  Harvard University, 細胞生物学分野, 専任講師
• From Jun. 2014, To Jun. 2015

  Harvard University, 細胞生物学分野, 博士研究員
• From Dec. 2010, To May 2014

  Kyoto University, Kyoto University, 助教

Profile

• Profile

  生体がいかにして酸化ストレス、低酸素ストレス、pHストレスなどのストレスを「感知」し、「応答/適応」しているのか、

  
  

  がんや生命進化の視点から研究を進めております。

ID,URL

• J-Global ID

  201801013780828580

• Researcher number

  70604635

• External link

  https://www.hakubi.kyoto-u.takahashi-group.net

Website(s) (URL(s))

• https://www.hakubi.kyoto-u.takahashi-group.net

researchmap URL

• https://researchmap.jp/0404

Research

Research Interests

• pHストレス
• 低酸素ストレス
• 酸化ストレス
• 発生
• 化学進化
• がん生物学
• TRPチャネル

Research Areas

• Life sciences, Functional biochemistry
• Life sciences, Medical biochemistry

Papers

• Intratumour oxidative hotspots provide a niche for cancer cell dissemination

  Yoshifumi Ueda; Shigeki Kiyonaka; Laura M. Selfors; Keisuke Inoue; Hiroshi Harada; Tomohiro Doura; Kunishige Onuma; Makoto Uchiyama; Ryuhei Kurogi; Yuji Yamada; Jiacheng H. Sun; Reiko Sakaguchi; Yuki Tado; Haruki Omatsu; Harufumi Suzuki; Mike Aoun; Takahiro Nakayama; Taketoshi Kajimoto; Tetsuya Yano; Rikard Holmdahl; Itaru Hamachi; Masahiro Inoue; Yasuo Mori; Nobuaki Takahashi

  Nature Cell Biology, 21 Feb. 2025, Peer-reviewed, Last author, Corresponding author

  
• [Ion channels responsible for environmental response: molecular function of TRP channels activated by reactive chemical species].

  Yamamoto S; Takahashi N; Kiyonaka S; Mori Y

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Mar. 2009, Invited

  
• The regulatory effect of oxaliplatin on human TRPA1 cold sensitivity

  Miyake Takahito; Nakamura Saki; Zhao Meng; So Kanako; Inoue Keisuke; Numata Tomohiro; Takahashi Nobuaki; Shirakawa Hisashi; Mori Yasuo; Nakagawa Takayuki; Kaneko Shuji

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017, Peer-reviewed

  
• Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein assembly potentiates the positive feedback interaction between Ca2+ and NO signals.

  Reiko Sakaguchi; Nobuaki Takahashi; Takashi Yoshida; Nozomi Ogawa; Yoshifumi Ueda; Satoshi Hamano; Kaori Yamaguchi; Seishiro Sawamura; Shinichiro Yamamoto; Yuji Hara; Tomoya Kawamoto; Ryosuke Suzuki; Akito Nakao; Masayuki X Mori; Tetsushi Furukawa; Shunichi Shimizu; Ryuji Inoue; Yasuo Mori

  J. Biol. Chem, 21 Aug. 2024, Peer-reviewed

  
• Activation of TRP channels in mammalian systems

  Tomohiro Numata; Shigeki Kiyonaka; Kenta Kato; Nobuaki Takahashi; Yasuo Mori

  TRP Channels, 19 Apr. 2016

  
• TRPA1 channel in the airway underlies protection against airborne threats by modulating respiration and behaviour

  Tomoyuki Kuwaki; Nobuaki Takahashi

  J. Physiol., 14 May 2023, Peer-reviewed, Invited

  
• N-Methylamide-structured SB366791 derivatives with high TRPV1 antagonistic activity: toward PET radiotracers to visualize TRPV1

  Tatsuya Kida, Nobuaki Takahashi (Co-first), Masayuki X. Mori, Jiacheng H. Sun, Hideto Oota, Kosuke Nishino, Takashi Okauchi, Yuta Ochi, Daisuke Kano, Ukihide Tateishi, Yasuyoshi Watanabe, Yilong Cui, Yasuo Mori, Hisashi Doi

  RSC Medicinal Chemistry, Sep. 2022, Peer-reviewed, Lead author

  
• 15-deoxy-Delta(12,14)-prostaglandin J(2) as a potential TRPV1-dependent atopic dermatitis enhancer

  Shibata Takahiro; Takahashi Katsuhiko; Matsubara Yui; Takahashi Nobuaki; Mori Yasuo; Uchida Koji

  FREE RADICAL BIOLOGY AND MEDICINE, Oct. 2014, Peer-reviewed

  
• Involvement of TRPA1 activation through distinct modifications in oxaliplatin-induced acute peripheral neuropathy

  Nakamura Saki; Miyake Takahito; Zhao Meng; Hamano Satoshi; Inoue Keisuke; Takahashi Nobuaki; Numata Tomohiro; Shirakawa Hisashi; Mori Yasuo; Nakagawa Takayuki; Kaneko Shuji

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, Peer-reviewed

  
• Activation of TRPA1 channels by transnitrosylating reagents

  Daisuke Kozai; Maximilian Ebert; Fumika Karaki; Yuko Otani; Yoji Kabasawa; Nobuaki Takahashi; Tomohiro Numata; Shigeki Kiyonaka; Tomohiko Ohwada; Yasuo Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Peer-reviewed

  
• Role of Oxidative Stress and Ca2+ Signaling in Psychiatric Disorders

  Akito Nakao; Yoshihiro Matsunaga; Katsumi Hayashida; Nobuaki Takahashi*

  Front. Cell Dev. Biol., Feb. 2021, Peer-reviewed, Invited, Last author, Corresponding author

  
• 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis.

  Nobuaki Takahashi (Corresponding Author); Patricia Cho; Laura M Selfors; Hendrik J Kuiken; Roma Kaul; Takuro Fujiwara; Isaac S Harris; Tian Zhang; Steven P Gygi; Joan S Brugge

  Mol Cell, 26 Oct. 2020, Peer-reviewed, Lead author, Corresponding author

  
• Transient Receptor Potential Ankyrin 1 Mediates Hypoxic Responses in Mice

  Sichong Chen; Nobuaki Takahashi (Co-first); Changping Chen; Jordan L. Pauli; Chiharu Kuroki; Jun Kaminosono; Hideki Kashiwadani; Yuichi Kanmura; Yasuo Mori; Shaowu Ou; Liying Hao; Tomoyuki Kuwaki

  Frontiers in Physiology, 22 Oct. 2020, Peer-reviewed, Lead author

  
• O2-Dependent Protein Internalization Underlies Astrocytic Sensing of Acute Hypoxia by Restricting Multimodal TRPA1 Channel Responses.

  Makoto Uchiyama; Akito Nakao; Yuki Kurita; Isato Fukushi; Kotaro Takeda; Tomohiro Numata; Ha Nam Tran; Seishiro Sawamura; Maximilian Ebert; Tatsuki Kurokawa; Reiko Sakaguchi; Alexander J Stokes; Nobuaki Takahashi; Yasumasa Okada; Yasuo Mori

  Current Biology, 07 Sep. 2020, Peer-reviewed

  
• Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

  Harris IS; Endress JE; Coloff JL; Selfors LM; McBrayer SK; Rosenbluth JM; Takahashi N; Dhakal S; Koduri V; Oser MG; Schauer NJ; Doherty LM; Hong AL; Kang YP; Younger ST; Doench JG; Hahn WC; Buhrlage SJ; DeNicola GM; Kaelin WG Jr; Brugge JS

  Cell Metabolism, May 2019, Peer-reviewed

  
• Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

  Nobuaki Takahashi; Hsing-Yu Chen; Isaac S. Harris; Daniel G. Stover; Laura M. Selfors; Roderick T. Bronson; Thomas Deraedt; Karen Cichowski; Alana L. Welm; Yasuo Mori; Gordon B. Mills; Joan S. Brugge

  Cancer Cell, 11 Jun. 2018, Peer-reviewed, Lead author

  
• Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin

  Takahito Miyake; Saki Nakamura; Zhao Meng; Satoshi Hamano; Keisuke Inoue; Tomohiro Numata; Nobuaki Takahashi; Kazuki Nagayasu; Hisashi Shirakawa; Yasuo Mori; Takayuki Nakagawa; Shuji Kaneko

  FRONTIERS IN PHYSIOLOGY, Nov. 2017, Peer-reviewed

  
• TRP channels in oxygen physiology: distinctive functional properties and roles of TRPA1 in O-2 sensing

  Yasuo Mori; Nobuaki Takahashi; Tatsuki Kurokawa; Shigeki Kiyonaka

  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, Jul. 2017, Peer-reviewed

  
• Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

  Takahito Miyake; Saki Nakamura; Meng Zhao; Kanako So; Keisuke Inoue; Tomohiro Numata; Nobuaki Takahashi; Hisashi Shirakawa; Yasuo Mori; Takayuki Nakagawa; Shuji Kaneko

  NATURE COMMUNICATIONS, Sep. 2016, Peer-reviewed

  Access this paper :

  
• Functional and Structural Divergence in Human TRPV1 Channel Subunits by Oxidative Cysteine Modification

  Nozomi Ogawa; Tatsuki Kurokawa; Kenji Fujiwara; Onur Kerem Polat; Heba Badr; Nobuaki Takahashi; Yasuo Mori

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2016, Peer-reviewed

  
• Identification of a prostaglandin D-2 metabolite as a neuritogenesis enhancer targeting the TRPV1 ion channel

  Takahiro Shibata; Katsuhiro Takahashi; Yui Matsubara; Emi Inuzuka; Fumie Nakashima; Nobuaki Takahashi; Daisuke Kozai; Yasuo Mori; Koji Uchida

  SCIENTIFIC REPORTS, Feb. 2016, Peer-reviewed

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• Redox-sensitive transient receptor potential channels in oxygen sensing and adaptation

  Yasuo Mori; Nobuaki Takahashi; Onur Kerem Polat; Tatsuki Kurokawa; Norihiko Takeda; Masahiro Inoue

  PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Jan. 2016, Peer-reviewed, Invited

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• Oxygen physiology: sensors and ion channels

  Yasuo Mori; Nobuaki Takahashi; Nozomi Ogawa; Thomas Gudermann

  PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Jan. 2016, Invited

  
• Inhibitory effects of AG490 on H2O2-induced TRPM2-mediated Ca2+ entry

  Shunichi Shimizu; Ryo Yonezawa; Tamio Hagiwara; Takashi Yoshida; Nobuaki Takahashi; Satoshi Hamano; Takaharu Negoro; Takahiro Toda; Minoru Wakamori; Yasuo Mori; Masakazu Ishii

  EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2014, Peer-reviewed

  
• TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P-2

  Nobuaki Takahashi; Sayaka Hamada-Nakahara; Yuzuru Itoh; Kazuhiro Takemura; Atsushi Shimada; Yoshifumi Ueda; Manabu Kitamata; Rei Matsuoka; Kyoko Hanawa-Suetsugu; Yosuke Senju; Masayuki X. Mori; Shigeki Kiyonaka; Daisuke Kohda; Akio Kitao; Yasuo Mori; Shiro Suetsugu

  Nature Commun, Sep. 2014, Peer-reviewed, Lead author

  
• The O-2- sensing TRPA1 channel illustrates the significance of vagal nerves in cardio- respiratory adaptation to hypoxia

  N. Takahashi; Y. Mori

  ACTA PHYSIOLOGICA, Apr. 2014, Invited, Lead author

  
• Transnitrosylation Directs TRPA1 Selectivity in N-Nitrosamine Activators

  Daisuke Kozai; Yoji Kabasawa; Maximilian Ebert; Shigeki Kiyonaka; Firman Yuko Otani; Tomohiro Numata; Nobuaki Takahashi; Yasuo Mori; Tomohiko Ohwada

  MOLECULAR PHARMACOLOGY, Jan. 2014, Peer-reviewed

  
• TRPs as chemosensors (ROS, RNS, RCS, gasotransmitters)

  Shunichi Shimizu; Nobuaki Takahashi; Yasuo Mori

  Handbook of Experimental Pharmacology, 2014, Peer-reviewed, Invited

  
• TRPA1 detects environmental chemicals and induces avoidance behavior and arousal from sleep

  Toru Yonemitsu; Chiharu Kuroki; Nobuaki Takahashi; Yasuo Mori; Yuichi Kanmura; Hideki Kashiwadani; Youichirou Ootsuka; Tomoyuki Kuwaki

  SCIENTIFIC REPORTS, Oct. 2013, Peer-reviewed

  
• TRP channels as sensors of oxygen availability

  Tomohiro Numata; Nozomi Ogawa; Nobuaki Takahashi; Yasuo Mori

  PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Aug. 2013, Peer-reviewed, Invited

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• TRP channels: sensors and transducers of gasotransmitter signals

  Nobuaki Takahashi; Daisuke Kozai; Yasuo Mori

  FRONTIERS IN PHYSIOLOGY, 2012, Peer-reviewed, Invited, Lead author

  
• TRPA1 underlies a sensing mechanism for O-2

  Nobuaki Takahashi; Tomoyuki Kuwaki; Shigeki Kiyonaka; Tomohiro Numata; Daisuke Kozai; Yusuke Mizuno; Shinichiro Yamamoto; Shinji Naito; Ellen Knevels; Peter Carmeliet; Toru Oga; Shuji Kaneko; Seiji Suga; Toshiki Nokami; Jun-ichi Yoshida; Yasuo Mori

  Nature Chem Biol, Oct. 2011, Peer-reviewed, Lead author

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• Roles of TRPM2 in oxidative stress

  Nobuaki Takahashi; Daisuke Kozai; Ryohei Kobayashi; Maximilian Ebert; Yasuo Mori

  CELL CALCIUM, Sep. 2011, Peer-reviewed, Invited, Lead author

  
• Receptor Signaling Integration by TRP Channelsomes

  Yasuo Mori; Taketoshi Kajimoto; Akito Nakao; Nobuaki Takahashi; Shigeki Kiyonaka

  TRANSIENT RECEPTOR POTENTIAL CHANNELS, 2011, Invited

  
• TRP channels as sensors and signal integrators of redox status changes

  Nobuaki Takahashi; Yasuo Mori

  FRONTIERS IN PHARMACOLOGY, 2011, Peer-reviewed, Invited, Lead author

  
• Activation of TRP Channels in Mammalian Systems

  Numata T; Kiyonaka S; Kato K; Takahashi N; Mori Y; Zhu MX

  2011, Peer-reviewed

  
• Chemical physiology of oxidative stress-activated TRPM2 and TRPC5 channels

  Shinichiro Yamamoto; Nobuaki Takahashi; Yasuo Mori

  PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, Sep. 2010, Peer-reviewed, Invited

  Access this paper :

  
• Differential redox regulation of ORAI ion channels: A mechanism to tune cellular Calcium signaling

  Ivan Bogeski; Carsten Kummerow; Dalia Al-Ansary; Eva C. Schwarz; Richard Koehler; Daisuke Kozai; Nobuaki Takahashi; Christine Peinelt; Desiree Griesemer; Monika Bozem; Yasuo Mori; Markus Hoth; Barbara A. Niemeyer

  Science Signaling, 30 Mar. 2010, Peer-reviewed

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• Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling

  Ivan Bogeski; Carsten Kummerow; Dalia Al-Ansary; Eva C. Schwarz; Richard Koehler; Daisuke Kozai; Nobuaki Takahashi; Christine Peinelt; Desiree Griesemer; Monika Bozem; Yasuo Mori; Markus Hoth; Barbara A. Niemeyer

  SCIENCE SIGNALING, Mar. 2010, Peer-reviewed

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• TRPM2-mediated Ca(2+) influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

  Shinichiro Yamamoto; Shunichi Shimizu; Shigeki Kiyonaka; Nobuaki Takahashi; Teruaki Wajima; Yuji Hara; Takaharu Negoro; Toshihito Hiroi; Yuji Kiuchi; Takaharu Okada; Shuji Kaneko; Ingo Lange; Andrea Fleig; Reinhold Penner; Miyuki Nishi; Hiroshi Takeshima; Yasuo Mori

  Nature Med, Jul. 2008, Peer-reviewed

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• Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators

  Nobuaki Takahashi; Yusuke Mizuno; Daisuke Kozai; Shinichiro Yamamoto; Shigeki Kiyonaka; Takahiro Shibata; Koji Uchida; Yasuo Mori

  Channels, Jul. 2008, Peer-reviewed, Lead author

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• Nitric oxide activates TRP channels by cysteine S-nitrosylation

  Takashi Yoshida; Ryuji Inoue; Takashi Morii; Nobuaki Takahashi; Shinichiro Yamamoto; Yuji Hara; Makoto Tominaga; Shunichi Shimizu; Yoji Sato; Yasuo Mori

  Nature Chem Biol, Nov. 2006, Peer-reviewed

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Books and Other Publications

• 酸化ストレス反応を標的としたがん治療創薬

  高橋重成; 植田誉志史

  酸化ストレスの医学第3版, May 2024

  
• TRPA1 チャネルによるがん酸化ストレス防御

  高橋重成

  日薬理誌, Nov. 2023

  
• 「学術変革領域」採択領域代表者に聞きました

  高橋重成, pHに対する「生物学的」理解に変革を起こす！

  実験医学, May 2021

  
• 内因性のストレスを積極的に活用するイオンチャネル機構

  高橋重成, 森 泰生

  実験医学, Jun. 2020

  
• 新規Ca²⁺チャネルTRPA1はがん細胞の酸化ストレス耐性を担う

  高橋 重成

  がん分子標的治療, Dec. 2019, Not refereed

  
• がん細胞はワサビ受容体を発現することで酸化ストレス耐性を亢進させている

  高橋 重成

  実験医学, Oct. 2018, Not refereed

  
• がん細胞は感覚受容の分子機構をハイジャックすることで酸化ストレス耐性機能を亢進させている

  高橋重成; 森泰生; Joan; S. Brugge

  新着論文レビュー, Jun. 2018, Not refereed

  
• TRPV4イオンチャネルのアンキリンリピート ドメインとPI(4,5)P2の相互作用による新たな制御機構

  末次志郎; 高橋重成; 伊藤弓弦; 竹村和浩; 嶋田 睦; 北尾彰朗; 森 泰生

  生物物理, Jul. 2015, Not refereed

  
• TRPA1チャネルを介した酸素・活性酸素種センシング

  植田誉志史; 高橋重成; 森泰生

  実験医学, Oct. 2012, Not refereed

  
• TRP チャネルを介する新しい酸素センシング機構

  高橋重成; 植田誉志史; 森泰生

  実験医学, May 2012, Not refereed

  
• TRPA1チャネルによる酸素感受性

  高橋 重成

  医学のあゆみ, Apr. 2012, Not refereed

  
• 活性酸素で活性化されるTRPチャネル

  清中茂樹; 高橋重成; 森泰生

  ファルマシア, 2012, Not refereed

  Access this books etc. :

  
• 新たな酸素センサー／チャネルによる低酸素応答制御

  植田誉志史; 高橋重成; 森泰生

  血管医学, 2012, Not refereed

  
• 酸素を検知する生体内ケモセンサーイオンチャネル

  森泰生; 高橋重成

  化学マスター講座 一般化学（丸善）, 2012, Not refereed

  
• TRPA1チャネルが担う生体における新しいO2センサー機構

  高橋 重成; 森 泰生

  新着論文レビュー, Sep. 2011, Not refereed

  
• イオンチャネル

  森泰生; 高橋重成

  トランスポートソームの世界, 2011, Not refereed

  
• 生体内センサーとしてのイオンチャネル 総論

  森泰生; 沼田朋大; 高橋重成

  トランスポートソームの世界, 2011, Not refereed

  
• TRP チャネルの構造と多様な機能

  沼田朋大; 香西大輔; 高橋重成; 加藤賢太; 瓜生幸嗣; 山本伸一郎; 金子雄; 眞本達生; 森泰生

  生化学, Nov. 2009, Not refereed

  
• TRPチャネル

  高橋 重成

  Medical Tribuneことばのカルテ, Nov. 2009, Not refereed

  
• 酸化ストレス作動性TRP チャネルの化学生理

  高橋重成; 山本伸一郎; 森泰生

  実験医学, Sep. 2009, Not refereed

  
• 活性化学種感応のチャネル機構の探求

  山本伸一郎; 高橋重成; 清中茂樹; 森泰生

  蛋白質核酸酵素, 2009, Not refereed

  
• 化学物質の感覚分子生物学―TRPチャネルはどのように物質を感知し脳へ伝えるか―

  清中茂樹; 高橋重成; 香西大輔; 森泰生

  化学, 2009, Not refereed

  
• TRPCチャネルによる血管トーヌスの調節

  高橋重成; 秋山智志; 水野雄介; 井上隆司; 森泰生

  医学のあゆみ, Dec. 2007, Not refereed

  
• カルシウムシグナル制御チャネルの作用化合物と創薬

  清中茂樹; 加藤賢太; 高橋重成; 正木隆男; 森泰生

  医学のあゆみ, 2007, Not refereed

  

Awards

• 07 Apr. 2020

  文部科学省, 文部科学大臣表彰 若手科学者賞
• 11 Sep. 2011

  日本生化学会, 鈴木紘一メモリアル賞
• 27 Jan. 2008

  特定領域研究「G蛋白質シグナル」&「膜輸送複合体」合同若手ワークショップ2008, 優秀発表賞
• 16 Dec. 2012

  日本生化学会, 鈴木紘一メモリアル賞
• 28 Mar. 2013

  日本生理学会, 佐川喜一賞
• 04 Feb. 2014

  井上科学振興財団, 井上研究奨励賞
• 11 Aug. 2011

  The Society for Neuroscience, "Hot topic" Research

External funds: Kakenhi

• Identification of pH-induced transcription factors governing pH stress adaptation

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  Nobuaki Takakahashi

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  pH;pHストレス適応;がん;転写因子;pH適応;ストレス感知;TRPチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05788/
• Establishment of pH Biology

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  Nobuaki Takakahashi

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  pH;pHストレス適応;シグナル伝達;がん;発生;海洋酸性化;pH適応;転写因子

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20H05787/
• Establishment of pH Biology

  Grant-in-Aid for Transformative Research Areas (B)

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-20B308/
• Physiologicalsignificance or redox-sensitive ion channels

  Grant-in-Aid for Research Activity Start-up

  Kyoto University

  Nobuaki TAKAHASHI

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  TRPチャネル;酸素;低酸素;高酸素;レドックス;呼吸;TRPA1;迷走神経;イオンチャネル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23800035/
• 低酸素センサーTRPA1チャネルが司る生物学的意義の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43030:Functional biochemistry-related

  Kyoto University

  高橋 重成

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  TRPチャネル;低酸素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01976/
• 哺乳類の赤血球はなぜ脱核したのか？

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 48:Biomedical structure and function and related fields

  Kyoto University

  高橋 重成

  From 28 Jun. 2024, To 31 Mar. 2026, Granted

  赤血球;進化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K22034/
• pHストレス誘導型転写因子の同定

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  高橋 重成

  From 01 Apr. 2025, To 31 Mar. 2030, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-25H01331/
• Establishment of pH Biology

  Grant-in-Aid for Transformative Research Areas (B)

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-20B308/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Chemistry Scientific English

  7430, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Biochemistry I (Advanced Chemistry)

  7416, Spring, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Biochemistry II

  7064, Fall, Faculty of Engineering, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Frontiers in the Field of Chemical Biology and Biological Chemistry

  H409, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Biology

  H812, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biological Chemistry 2 Continued

  P836, Spring, Graduate School of Engineering, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Biological Chemistry

  H836, Spring, Graduate School of Engineering, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Biochemical Engineering

  7030, Fall, Faculty of Engineering, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Biology

  H812, Spring, Graduate School of Engineering, 1.5
• From Apr. 2020, To Mar. 2021

  Molecular Biology

  Spring, 工学研究科
• From Apr. 2020, To Mar. 2021

  Biochemical Engineering

  Fall, 工学部
• From Apr. 2021, To Mar. 2022

  Biochemical Engineering

  Fall, 工学部

Academic, Social Contribution

Academic Contribution

• 国立科学博物館市民向け講座「pH/CO2が支える地球上の生命」

  Planning, management, etc., Panel moderator

  国立科学博物館・高橋重成, From 02 Oct. 2022

  
• 極限環境の生命について竹内 洋岳 氏 （プロ登山家）との 1対1 公開討論

  Panel moderator

  京都大学地球環境学堂, From Nov. 2013

  
• 酸素がもたらす生物の進化

  京都大学地球環境学堂, From Nov. 2013