Basic Information

Faculty

• Faculty of Medicine

Academic Degree

• 博士（医学）(京都大学)

ID,URL

• J-Global ID

  201401073715067930

researchmap URL

• https://researchmap.jp/7000009493

Research

Research Topics, Overview of the research

• Research Topics

  Molecular pathogenesis and novel treatment strategy for HIV-1/AIDS and lymphoid malignancies

• Overview of the research

  Our research focuses on 1) molecular mechanisms of HIV-1 latency, 2) genomic mutation and cancer development by cytidine deaminase APOBEC3, 3) roles of reversible lysine acetylation in lymphoid malignancy.

Research Areas

• Life sciences, Hematology and oncology

Papers

• 急性白血病における新規RNA分子及び治療標的の同定

  和田 典也; 加藤 匠矢; シュルティー・バーガット; 平林 茂樹; 孫 楽; 小口 綾貴子; 竹内 一博; 関戸 翔; 平井 公也; チャン・ジーウェイ; 岩崎 惇; 諫田 淳也; 阪本 貴士; 白川 康太郎; 高折 晃史; 村川 泰裕

  日本血液学会学術集会, Oct. 2023

  
• CAR-T細胞療法後に肺動脈内のT細胞塊を認めたtriple-hit DLBCLの1例

  中村 直和; 錦織 桃子; 水本 智咲; 阪本 貴士; 諫田 淳也; 白川 康太郎; 北脇 年雄; 近藤 忠一; 山下 浩平; 高折 晃史

  臨床血液, Aug. 2022

  
• Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

  Ito, J.; Suzuki, R.; Uriu, K.; Itakura, Y.; Zahradnik, J.; Kimura, K.T.; Deguchi, S.; Wang, L.; Lytras, S.; Tamura, T.; Kida, I.; Nasser, H.; Shofa, M.; Begum, M.M.; Tsuda, M.; Oda, Y.; Suzuki, T.; Sasaki, J.; Sasaki-Tabata, K.; Fujita, S.; Yoshimatsu, K.; Ito, H.; Nao, N.; Asakura, H.; Nagashima, M.; Sadamasu, K.; Yoshimura, K.; Yamamoto, Y.; Nagamoto, T.; Kuramochi, J.; Schreiber, G.; Suzuki, S.; Kato, M.; Ferdous, Z.; Mouri, H.; Shishido, K.; Misawa, N.; Kimura, I.; Kosugi, Y.; Lin, P.; Suganami, M.; Chiba, M.; Yoshimura, R.; Yasuda, K.; Iida, K.; Ohsumi, N.; Strange, A.P.; Sauter, D.; Nakagawa, S.; Wu, J.; Watanabe, Y.; Sakamoto, A.; Yasuhara, N.; Nakajima, Y.; Yajima, H.; Shirakawa, K.; Takaori-Kondo, A.; Nagata, K.; Kazuma, Y.; Nomura, R.; Horisawa, Y.; Tashiro, Y.; Kawa, Y.; Irie, T.; Kawabata, R.; Shimizu, R.; Takahashi, O.; Ichihara, K.; Motozono, C.; Toyoda, M.; Ueno, T.; Shibatani, Y.; Nishiuchi, T.; Saito, A.; Matsuno, K.; Takayama, K.; Hashiguchi, T.; Tanaka, S.; Fukuhara, T.; Ikeda, T.; Sato, K.

  Nature Communications, 2023

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• Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

  Tamura, T.; Ito, J.; Uriu, K.; Zahradnik, J.; Kida, I.; Anraku, Y.; Nasser, H.; Shofa, M.; Oda, Y.; Lytras, S.; Nao, N.; Itakura, Y.; Deguchi, S.; Suzuki, R.; Wang, L.; Begum, M.M.; Kita, S.; Yajima, H.; Sasaki, J.; Sasaki-Tabata, K.; Shimizu, R.; Tsuda, M.; Kosugi, Y.; Fujita, S.; Pan, L.; Sauter, D.; Yoshimatsu, K.; Suzuki, S.; Asakura, H.; Nagashima, M.; Sadamasu, K.; Yoshimura, K.; Yamamoto, Y.; Nagamoto, T.; Schreiber, G.; Maenaka, K.; Ito, H.; Misawa, N.; Kimura, I.; Suganami, M.; Chiba, M.; Yoshimura, R.; Yasuda, K.; Iida, K.; Ohsumi, N.; Strange, A.P.; Takahashi, O.; Ichihara, K.; Shibatani, Y.; Nishiuchi, T.; Kato, M.; Ferdous, Z.; Mouri, H.; Shishido, K.; Sawa, H.; Hashimoto, R.; Watanabe, Y.; Sakamoto, A.; Yasuhara, N.; Suzuki, T.; Kimura, K.; Nakajima, Y.; Nakagawa, S.; Wu, J.; Shirakawa, K.; Takaori-Kondo, A.; Nagata, K.; Kazuma, Y.; Nomura, R.; Horisawa, Y.; Tashiro, Y.; Kawai, Y.; Irie, T.; Kawabata, R.; Motozono, C.; Toyoda, M.; Ueno, T.; Hashiguchi, T.; Ikeda, T.; Fukuhara, T.; Saito, A.; Tanaka, S.; Matsuno, K.; Takayama, K.; Sato, K.

  Nature Communications, 2023

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• Intratracheal trimerized nanobody cocktail protects against SARS-CoV-2 Omicron in mice

  Kayoko Nagata; Daichi Utsumi; Masamitsu Asaka; Ryota Maeda; Kotaro Shirakawa; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Yohei Yanagida; Yugo Kawai; Kei Sato; Yutaro Yamaoka; Kei Miyakawa; Akihide Ryo; Yasuhiro Yasutomi; Akihiro Imura; Akifumi Takaori-Kondo

  22 Apr. 2022

  
• Monitoring fusion kinetics of viral and target cell membranes in living cells using a SARS-CoV-2 spike-protein-mediated membrane fusion assay

  Nasser, H.; Shimizu, R.; Ito, J.; Matsuno, K.; Nao, N.; Sawa, H.; Kishimoto, M.; Tanaka, S.; Tsuda, M.; Wang, L.; Oda, Y.; Kato, M.; Ferdous, Z.; Mouri, H.; Shishido, K.; Fukuhara, T.; Tamura, T.; Suzuki, R.; Ito, H.; Yamasoba, D.; Kimura, I.; Misawa, N.; Uriu, K.; Kosugi, Y.; Fujita, S.; Suganami, M.; Chiba, M.; Yoshimura, R.; Nakagawa, S.; Wu, J.; Takaori-Kondo, A.; Shirakawa, K.; Nagata, K.; Kazuma, Y.; Nomura, R.; Horisawa, Y.; Tashiro, Y.; Kawai, Y.; Irie, T.; Kawabata, R.; Begum, M.M.; Takahashi, O.; Ichihara, K.; Ueno, T.; Motozono, C.; Toyoda, M.; Tanaka, Y.L.; Butlertanaka, E.P.; Shofa, M.; Takayama, K.; Hashimoto, R.; Deguchi, S.; Hashiguchi, T.; Suzuki, T.; Kimura, K.; Sasaki, J.; Nakajima, Y.; Tabata, K.; Saito, A.; Sato, K.; Ikeda, T.

  STAR Protocols, 2022

  
• Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin.

  Tomoyuki Abe; Yoshihito Horisawa; Osamu Kikuchi; Hitomi Ozawa-Umeta; Atsuhiro Kishimoto; Yasuhiro Katsuura; Atsushi Imaizumi; Tadashi Hashimoto; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kosuke Yusa; Tadashi Asakura; Hideaki Kakeya; Masashi Kanai

  European journal of pharmacology, 15 Nov. 2022

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• Multiple mutations of SARS-CoV-2 Omicron BA.2 variant orchestrate its virological characteristics.

  Izumi Kimura; Daichi Yamasoba; Hesham Nasser; Hayato Ito; Jiri Zahradnik; Jiaqi Wu; Shigeru Fujita; Keiya Uriu; Jiei Sasaki; Tomokazu Tamura; Rigel Suzuki; Sayaka Deguchi; Arnon Plianchaisuk; Kumiko Yoshimatsu; Yasuhiro Kazuma; Shuya Mitoma; Gideon Schreiber; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Akifumi Takaori-Kondo; Jumpei Ito; Kotaro Shirakawa; Kazuo Takayama; Takashi Irie; Takao Hashiguchi; So Nakagawa; Takasuke Fukuhara; Akatsuki Saito; Terumasa Ikeda; Kei Sato

  Journal of virology, 05 Oct. 2023, Peer-reviewed

  
• Longitudinal analysis of genomic mutations in SARS-CoV-2 isolates from persistent COVID-19 patient.

  Hiroki Futatsusako; Rina Hashimoto; Masaki Yamamoto; Jumpei Ito; Yasufumi Matsumura; Hajime Yoshifuji; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kei Sato; Miki Nagao; Kazuo Takayama

  iScience, 17 May 2024

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• Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5.

  Izumi Kimura; Daichi Yamasoba; Tomokazu Tamura; Naganori Nao; Tateki Suzuki; Yoshitaka Oda; Shuya Mitoma; Jumpei Ito; Hesham Nasser; Jiri Zahradnik; Keiya Uriu; Shigeru Fujita; Yusuke Kosugi; Lei Wang; Masumi Tsuda; Mai Kishimoto; Hayato Ito; Rigel Suzuki; Ryo Shimizu; Mst Monira Begum; Kumiko Yoshimatsu; Kanako Terakado Kimura; Jiei Sasaki; Kaori Sasaki-Tabata; Yuki Yamamoto; Tetsuharu Nagamoto; Jun Kanamune; Kouji Kobiyama; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Kotaro Shirakawa; Akifumi Takaori-Kondo; Jin Kuramochi; Gideon Schreiber; Ken J Ishii; Takao Hashiguchi; Terumasa Ikeda; Akatsuki Saito; Takasuke Fukuhara; Shinya Tanaka; Keita Matsuno; Kei Sato

  Cell, 13 Oct. 2022

  
• Determination of the factors responsible for the tropism of SARS-CoV-2-related bat coronaviruses to Rhinolophus bat ACE2

  Shigeru Fujita; Yusuke Kosugi; Izumi Kimura; Kenzo Tokunaga; Jumpei Ito; Kei Sato; Keita Matsuno; Naganori Nao; Hirofumi Sawa; Shinya Tanaka; Masumi Tsuda; Lei Wang; Yoshikata Oda; Zannatul Ferdous; Kenji Shishido; Takasuke Fukuhara; Tomokazu Tamura; Rigel Suzuki; Saori Suzuki; Hayato Ito; Yu Kaku; Naoko Misawa; Arnon Plianchaisuk; Ziyi Guo; Alfredo A. Hinay; Keiya Uriu; Jarel Elgin M. Tolentino; Luo Chen; Lin Pan; Mai Suganami; Mika Chiba; Ryo Yoshimura; Kyoko Yasuda; Keiko Iida; Naomi Ohsumi; Adam P. Strange; Shiho Tanaka; Kazuhisa Yoshimura; Kenji Sadamasu; Mami Nagashima; Hiroyuki Asakura; Isao Yoshida; So Nakagawa; Akifumi Takaori-Kondo; Kayoko Nagata; Ryosuke Nomura; Yoshihito Horisawa; Yusuke Tashiro; Yugo Kawai; Kazuo Takayama; Rina Hashimoto; Sayaka Deguchi; Yukio Watanabe; Ayaka Sakamoto; Naoko Yasuhara; Takao Hashiguchi; Tateki Suzuki; Kanako Kimura; Jiei Sasaki; Yukari Nakajima; Hisano Yajima; Takashi Irie; Ryoko Kawabata; Kaori Tabata; Terumasa Ikeda; Hesham Nasser; Ryo Shimizu; M. S. T. Monira Begum; Michael Jonathan; Yuka Mugita; Otowa Takahashi; Kimiko Ichihara; Chihiro Motozono; Takamasa Ueno; Mako Toyoda; Akatsuki Saito; Maya Shofa; Yuki Shibatani; Tomoko Nishiuchi; Kotaro Shirakawa

  Journal of Virology, 31 Oct. 2023

  
• Characterization of the evolutionary and virological aspects of mutations in the receptor binding motif of the SARS-CoV-2 spike protein

  Yuuka Masuda; Hesham Nasser; Jiri Zahradnik; Shuya Mitoma; Ryo Shimizu; Kayoko Nagata; Akifumi Takaori-Kondo; Gideon Schreiber; Kotaro Shirakawa; Akatsuki Saito; Terumasa Ikeda; Jumpei Ito; Kei Sato

  Frontiers in Virology, 22 Dec. 2023

  
• Akaluc bioluminescence offers superior sensitivity to trackin vivodynamics of SARS-CoV-2 infection

  Tomokazu Tamura; Hayato Ito; Shiho Torii; Lei Wang; Rigel Suzuki; Shuhei Tusjino; Akifumi Kamiyama; Yoshitaka Oda; Yuhei Morioka; Saori Suzuki; Kotaro Shirakawa; Kei Sato; Kumiko Yoshimatsu; Yoshiharu Matsuura; Satoshi Iwano; Shinya Tanaka; Takasuke Fukuhara

  13 Oct. 2023

  
• Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.

  Akatsuki Saito; Tomokazu Tamura; Jiri Zahradnik; Sayaka Deguchi; Koshiro Tabata; Yuki Anraku; Izumi Kimura; Jumpei Ito; Daichi Yamasoba; Hesham Nasser; Mako Toyoda; Kayoko Nagata; Keiya Uriu; Yusuke Kosugi; Shigeru Fujita; Maya Shofa; Mst Monira Begum; Ryo Shimizu; Yoshitaka Oda; Rigel Suzuki; Hayato Ito; Naganori Nao; Lei Wang; Masumi Tsuda; Kumiko Yoshimatsu; Jin Kuramochi; Shunsuke Kita; Kaori Sasaki-Tabata; Hideo Fukuhara; Katsumi Maenaka; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Takamasa Ueno; Gideon Schreiber; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hirofumi Sawa; Takashi Irie; Takao Hashiguchi; Kazuo Takayama; Keita Matsuno; Shinya Tanaka; Terumasa Ikeda; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 09 Nov. 2022

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• HTLV-1 bZIP factor impairs DNA mismatch repair system.

  Maki Sakurada-Aono; Takashi Sakamoto; Masayuki Kobayashi; Yoko Takiuchi; Fumie Iwai; Kohei Tada; Hiroyuki Sasanuma; Shigeki Hirabayashi; Yasuhiro Murakawa; Kotaro Shirakawa; Chihiro Sakamoto; Keisuke Shindo; Jun-Ichirou Yasunaga; Masao Matsuoka; Yves Pommier; Shunichi Takeda; Akifumi Takaori-Kondo

  Biochemical and biophysical research communications, 21 Mar. 2023

  
• The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant.

  Izumi Kimura; Daichi Yamasoba; Hesham Nasser; Jiri Zahradnik; Yusuke Kosugi; Jiaqi Wu; Kayoko Nagata; Keiya Uriu; Yuri L Tanaka; Jumpei Ito; Ryo Shimizu; Toong Seng Tan; Erika P Butlertanaka; Hiroyuki Asakura; Kenji Sadamasu; Kazuhisa Yoshimura; Takamasa Ueno; Akifumi Takaori-Kondo; Gideon Schreiber; Mako Toyoda; Kotaro Shirakawa; Takashi Irie; Akatsuki Saito; So Nakagawa; Terumasa Ikeda; Kei Sato

  iScience, 22 Dec. 2022

  
• Intratracheal trimerized nanobody cocktail administration suppresses weight loss and prolongs survival of SARS-CoV-2 infected mice.

  Kayoko Nagata; Daichi Utsumi; Masamitsu N Asaka; Ryota Maeda; Kotaro Shirakawa; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Yohei Yanagida; Yugo Kawai; Kei Sato; Yutaro Yamaoka; Kei Miyakawa; Akihide Ryo; Yasuhiro Yasutomi; Akihiro Imura; Akifumi Takaori-Kondo

  Communications medicine, 26 Nov. 2022

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• COVID19による呼吸不全によりECMO管理下に抗HIV療法を継続した症例

  和田 典也; 松村 勝之; 津田 真弘; 尾崎 淳子; 助石 有沙美; 白川 康太郎; 米澤 淳; 甲斐 慎一; 田辺 直也; 伊藤 功朗; 平井 豊博; 高折 晃史

  日本エイズ学会誌, Nov. 2021

  
• Nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants

  Ryota Maeda; Junso Fujita; Yoshinobu Konishi; Yasuhiro Kazuma; Hiroyuki Yamazaki; Itsuki Anzai; Keishi Yamaguchi; Kazuki Kasai; Kayoko Nagata; Yutaro Yamaoka; Kei Miyakawa; Akihide Ryo; Kotaro Shirakawa; Fumiaki Makino; Yoshiharu Matsuura; Tsuyoshi Inoue; Akihiro Imura; Keiichi Namba; Akifumi Takaori-Kondo

  26 Oct. 2021

  
• Virological characteristics of the SARS-CoV-2 Omicron BA.2 spike.

  Daichi Yamasoba; Izumi Kimura; Hesham Nasser; Yuhei Morioka; Naganori Nao; Jumpei Ito; Keiya Uriu; Masumi Tsuda; Jiri Zahradnik; Kotaro Shirakawa; Rigel Suzuki; Mai Kishimoto; Yusuke Kosugi; Kouji Kobiyama; Teppei Hara; Mako Toyoda; Yuri L Tanaka; Erika P Butlertanaka; Ryo Shimizu; Hayato Ito; Lei Wang; Yoshitaka Oda; Yasuko Orba; Michihito Sasaki; Kayoko Nagata; Kumiko Yoshimatsu; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Jin Kuramochi; Motoaki Seki; Ryoji Fujiki; Atsushi Kaneda; Tadanaga Shimada; Taka-Aki Nakada; Seiichiro Sakao; Takuji Suzuki; Takamasa Ueno; Akifumi Takaori-Kondo; Ken J Ishii; Gideon Schreiber; Hirofumi Sawa; Akatsuki Saito; Takashi Irie; Shinya Tanaka; Keita Matsuno; Takasuke Fukuhara; Terumasa Ikeda; Kei Sato

  Cell, 02 May 2022, Peer-reviewed

  
• SARS-CoV-2 B.1.617 mutations L452 and E484Q are not synergistic for antibody evasion

  Isabella Ferreira; Steven Kemp; Rawlings Datir; Akatsuki Saito; Bo Meng; Partha Rakshit; Akifumi Takaori-Kondo; Yusuke Kosugi; Keiya Uriu; Izumi Kimura; Kotaro Shirakawa; Adam Abdullahi; Anurag Agarwal; Seiya Ozono; Kenzo Tokunaga; Kei Sato; Ravindra K Gupta

  The Journal of Infectious Diseases, 14 Jul. 2021

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• FRET-Based Detection and Quantification of HIV-1 Virion Maturation

  Sarca, A.D.; Sardo, L.; Fukuda, H.; Matsui, H.; Shirakawa, K.; Horikawa, K.; Takaori-Kondo, A.; Izumi, T.

  Frontiers in Microbiology, May 2021, Peer-reviewed

  
• CAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model

  Hiroyuki Matsui; Kotaro Shirakawa; Yoshinobu Konishi; Shigeki Hirabayashi; Anamaria Daniela Sarca; Hirofumi Fukuda; Ryosuke Nomura; Emani Stanford; Yoshihito Horisawa; Yasuhiro Kazuma; Tadahiko Matsumoto; Hiroyuki Yamazaki; Yasuhiro Murakawa; Emilie Battivelli; Eric Verdin; Yoshio Koyanagi; Akifumi Takaori-Kondo; Frank Kirchhoff

  Journal of Virology, 25 Mar. 2021, Peer-reviewed

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• APOBEC3B is preferentially expressed at the G2/M phase of cell cycle

  Shigeki Hirabayashi; Kotaro Shirakawa; Yoshihito Horisawa; Tadahiko Matsumoto; Hiroyuki Matsui; Hiroyuki Yamazaki; Anamaria Daniela Sarca; Yasuhiro Kazuma; Ryosuke Nomura; Yoshinobu Konishi; Suguru Takeuchi; Emani Stanford; Hideya Kawaji; Yasuhiro Murakawa; Akifumi Takaori-Kondo

  Biochemical and Biophysical Research Communications, Mar. 2021, Peer-reviewed

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• Alternative splicing of APOBEC3D generates functional diversity and its role as a DNA mutator

  Takei, H.; Fukuda, H.; Pan, G.; Yamazaki, H.; Matsumoto, T.; Kazuma, Y.; Fujii, M.; Nakayama, S.; Kobayashi, I.S.; Shindo, K.; Yamashita, R.; Shirakawa, K.; Takaori-Kondo, A.; Kobayashi, S.S.

  International Journal of Hematology, Sep. 2020, Peer-reviewed

  
• Critical role of PP2A-B56 family protein degradation in HIV-1 Vif mediated G2 cell cycle arrest

  Nagata, K.; Shindo, K.; Matsui, Y.; Shirakawa, K.; Takaori-Kondo, A.

  Biochemical and Biophysical Research Communications, Jun. 2020, Peer-reviewed

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• APOBEC3B reporter myeloma cell lines identify DNA damage response pathways leading to APOBEC3B expression

  Yamazaki, H.; Shirakawa, K.; Matsumoto, T.; Kazuma, Y.; Matsui, H.; Horisawa, Y.; Stanford, E.; Sarca, A.D.; Shirakawa, R.; Shindo, K.; Takaori-Kondo, A.

  PLoS ONE, 08 Jan. 2020, Peer-reviewed

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• Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells

  Hiroyuki Yamazaki; Kotaro Shirakawa; Tadahiko Matsumoto; Shigeki Hirabayashi; Yasuhiro Murakawa; Masayuki Kobayashi; Anamaria Daniela Sarca; Yasuhiro Kazuma; Hiroyuki Matsui; Wataru Maruyama; Hirofumi Fukuda; Ryutaro Shirakawa; Keisuke Shindo; Masaki Ri; Shinsuke Iida; Akifumi Takaori-Kondo

  Scientific Reports, Dec. 2019, Peer-reviewed

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• ワルファリン服用患者におけるダルナビル/リトナビルからラルテグラビルに変更した際のワルファリン投与量とPT(INR)の推移

  尾崎 淳子; 松村 勝之; 櫻井 香織; 米澤 淳; 白川 康太郎; 高折 晃史; 松原 和夫

  日本エイズ学会誌, Nov. 2019

  
• ワルファリン服用患者におけるダルナビル/リトナビルからラルテグラビルに変更した際のワルファリン投与量とPT(INR)の推移

  尾崎 淳子; 松村 勝之; 櫻井 香織; 米澤 淳; 白川 康太郎; 高折 晃史; 松原 和夫

  日本エイズ学会誌, Nov. 2019

  
• NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements

  Shigeki Hirabayashi; Shruti Bhagat; Yu Matsuki; Yujiro Takegami; Takuya Uehata; Ai Kanemaru; Masayoshi Itoh; Kotaro Shirakawa; Akifumi Takaori-Kondo; Osamu Takeuchi; Piero Carninci; Shintaro Katayama; Yoshihide Hayashizaki; Juha Kere; Hideya Kawaji; Yasuhiro Murakawa

  Nature genetics, Sep. 2019, Peer-reviewed

  
• Protein kinase A inhibits tumor mutator APOBEC3B through phosphorylation.

  Matsumoto T; Shirakawa K; Yokoyama M; Fukuda H; Sarca AD; Koyabu S; Yamazaki H; Kazuma Y; Matsui H; Maruyama W; Nagata K; Tanabe F; Kobayashi M; Shindo K; Morishita R; Sato H; Takaori-Kondo A

  Sci Rep., Jun. 2019, Peer-reviewed

  
• A screening for DNA damage response molecules that affect HIV-1 infection

  Noriyoshi Yoshinaga; Keisuke Shindo; Yusuke Matsui; Yoko Takiuchi; Hirofumi Fukuda; Kayoko Nagata; Kotaro Shirakawa; Masayuki Kobayashi; Shunichi Takeda; Akifumi Takaori-Kondo

  Biochemical and Biophysical Research Communications, May 2019, Peer-reviewed

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• Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association.

  Hirofumi Fukuda; Songling Li; Luca Sardo; Jessica L Smith; Kazuo Yamashita; Anamaria D Sarca; Kotaro Shirakawa; Daron M Standley; Akifumi Takaori-Kondo; Taisuke Izumi

  Frontiers in cellular and infection microbiology, 2019, Peer-reviewed

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• 選択的HDAC3阻害による蛋白アセチル化を介したアポトーシス誘導機構の検討(Selective HDAC3 inhibition induces apoptosis in B cell lymphoma through protein acetylation)

  松井 宏行; 白川 康太郎; Chang Hsin-Yi; Daniela Sarca. A.; 数馬 安浩; 福田 寛文; 山崎 寛章; 松本 忠彦; 石濱 泰; 高折 晃史

  臨床血液, Sep. 2018, Peer-reviewed

  
• Choledochoduodenal fistula during chemotherapy with brentuximab vedotin for methotrexate-associated lymphoproliferative disorder

  Eso, Y.; Uza, N.; Shirakawa, K.; Sawada, K.; Katsuragi, K.; Matsuura, M.; Seno, H.

  Internal Medicine, May 2018, Peer-reviewed

  
• Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T-cell leukemia

  Takahito Kawata; Kohei Tada; Masayuki Kobayashi; Takashi Sakamoto; Yoko Takiuchi; Fumie Iwai; Maki Sakurada; Masakatsu Hishizawa; Kotaro Shirakawa; Keisuke Shindo; Hironori Sato; Akifumi Takaori-Kondo

  Cancer Science, 01 Jan. 2018, Peer-reviewed

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• HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia

  Yoko Takiuchi; Masayuki Kobayashi; Kohei Tada; Fumie Iwai; Maki Sakurada; Shigeki Hirabayashi; Kayoko Nagata; Kotaro Shirakawa; Keisuke Shindo; Jun-ichirou Yasunaga; Yasuhiro Murakawa; Vinodh Rajapakse; Yves Pommier; Masao Matsuoka; Akifumi Takaori-Kondo

  SCIENTIFIC REPORTS, Oct. 2017, Peer-reviewed

  
• Expression of Tim-1 in primary CNS lymphoma

  Wataru Kishimoto; Momoko Nishikori; Hiroshi Arima; Hiroaki Miyoshi; Yuya Sasaki; Toshio Kitawaki; Kotaro Shirakawa; Takeharu Kato; Yoshitaka Imaizumi; Takayuki Ishikawa; Hitoshi Ohno; Hironori Haga; Koichi Ohshima; Akifumi Takaori-Kondo

  CANCER MEDICINE, Nov. 2016, Peer-reviewed

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• Core Binding Factor beta Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation

  Yusuke Matsui; Keisuke Shindo; Kayoko Nagata; Noriyoshi Yoshinaga; Kotaro Shirakawa; Masayuki Kobayashi; Akifumi Takaori-Kondo

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2016, Peer-reviewed

  
• Classical NF-kB pathway is responsible for APOBEC3B expression in cancer cells

  Wataru Maruyama; Kotaro Shirakawa; Hiroyuki Matsui; Tadahiko Matsumoto; Hiroyuki Yamazaki; Anamaria D. Sarca; Yasuhiro Kazuma; Masayuki Kobayashi; Keisuke Shindo; Akifumi Takaori-Kondo

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2016, Peer-reviewed

  
• Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

  Kotaro Shirakawa; Lan Wang; Na Man; Jasna Maksimoska; Alexander W. Sorum; Hyung W. Lim; Intelly S. Lee; Tadahiro Shimazu; John C. Newman; Sebastian Schroder; Melanie Ott; Ronen Marmorstein; Jordan Meier; Stephen Nimer; Eric Verdin

  ELIFE, May 2016, Peer-reviewed

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• Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

  Christopher D. Wiley; Michael C. Velarde; Pacome Lecot; Su Liu; Ethan A. Sarnoski; Adam Freund; Kotaro Shirakawa; Hyung W. Lim; Sonnet S. Davis; Arvind Ramanathan; Akos A. Gerencser; Eric Verdin; Judith Campisi

  CELL METABOLISM, Feb. 2016, Peer-reviewed

  
• Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

  Sang-Won Min; Xu Chen; Tara E. Tracy; Yaqiao Li; Yungui Zhou; Chao Wang; Kotaro Shirakawa; S. Sakura Minami; Erwin Defensor; Sue Ann Mok; Peter Dongmin Sohn; Birgit Schilling; Xin Cong; Lisa Ellerby; Bradford W. Gibson; Jeffrey Johnson; Nevan Krogan; Mehrdad Shamloo; Jason Gestwicki; Eliezer Masliah; Eric Verdin; Li Gan

  NATURE MEDICINE, Oct. 2015, Peer-reviewed

  
• SIRT1 deacetylates ROR gamma t and enhances Th17 cell generation

  Hyung W. Lim; Seung Goo Kang; Jae Kyu Ryu; Birgit Schilling; Mingjian Fei; Intelly S. Lee; Amanuel Kehasse; Kotaro Shirakawa; Masaru Yokoyama; Martina Schnoelzer; Herbert G. Kasler; Hye-Sook Kwon; Bradford W. Gibson; Hironori Sato; Katerina Akassoglou; Changchun Xiao; Dan R. Littman; Melanie Ott; Eric Verdin

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2015, Peer-reviewed

  
• Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia.

  Kohei Tada; Masayuki Kobayashi; Yoko Takiuchi; Fumie Iwai; Takashi Sakamoto; Kayoko Nagata; Masanobu Shinohara; Katsuhiro Io; Kotaro Shirakawa; Masakatsu Hishizawa; Keisuke Shindo; Norimitsu Kadowaki; Kouji Hirota; Junpei Yamamoto; Shigenori Iwai; Hiroyuki Sasanuma; Shunichi Takeda; Akifumi Takaori-Kondo

  Science advances, Apr. 2015, Peer-reviewed

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• Abacavir, an anti-HIV-1 drug, targets TDP1-deficient adult T cell leukemia.

  Tada K; Kobayashi M; Takiuchi Y; Iwai F; Sakamoto T; Nagata K; Shinohara M; Io K; Shirakawa K; Hishizawa M; Shindo K; Kadowaki N; Hirota K; Yamamoto J; Iwai S; Sasanuma H; Takeda S; Takaori-Kondo A

  Sci Adv., Apr. 2015, Peer-reviewed

  
• Successful treatment with recombinant thrombomodulin for disseminated intravascular coagulation complicated with hemophagocytic syndrome.

  Yamazaki H; Kondo T; Tatsumi G; Kotani S; Arai Y; Shirakawa K; Kitano T; Hishizawa M; Kadowaki N; Takaori-Kondo A

  [Rinsho ketsueki] The Japanese journal of clinical hematology, 2015, Peer-reviewed

  
• Reactivation of latent HIV by histone deacetylase inhibitors

  Kotaro Shirakawa; Leonard Chavez; Shweta Hakre; Vincenzo Calvanese; Eric Verdin

  TRENDS IN MICROBIOLOGY, Jun. 2013, Peer-reviewed

  
• Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor

  Shimazu, T.; Hirschey, M.D.; Newman, J.; He, W.; Shirakawa, K.; Le Moan, N.; Grueter, C.A.; Lim, H.; Saunders, L.R.; Stevens, R.D.; Newgard, C.B.; Farese Jr., R.V.; De Cabo, R.; Ulrich, S.; Akassoglou, K.; Verdin, E.

  Science, Jan. 2013, Peer-reviewed

  
• An In-Depth Comparison of Latent HIV-1 Reactivation in Multiple Cell Model Systems and Resting CD4+ T Cells from Aviremic Patients

  Spina, C.A.; Anderson, J.; Archin, N.M.; Bosque, A.; Chan, J.; Famiglietti, M.; Greene, W.C.; Kashuba, A.; Lewin, S.R.; Margolis, D.M.; Mau, M.; Ruelas, D.; Saleh, S.; Shirakawa, K.; Siliciano, R.F.; Singhania, A.; Soto, P.C.; Terry, V.H.; Verdin, E.; Woelk, C.; Wooden, S.; Xing, S.; Planelles, V.

  PLoS Pathogens, 2013, Peer-reviewed

  
• HIV latency: experimental systems and molecular models

  Shweta Hakre; Leonard Chavez; Kotaro Shirakawa; Eric Verdin

  FEMS MICROBIOLOGY REVIEWS, May 2012, Peer-reviewed

  
• Epigenetic regulation of HIV latency

  Shweta Hakre; Leonard Chavez; Kotaro Shirakawa; Eric Verdin

  CURRENT OPINION IN HIV AND AIDS, Jan. 2011, Peer-reviewed

  
• HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication

  Taisuke Izumi; Katsuhiro Io; Masashi Matsui; Kotaro Shirakawa; Masanobu Shinohara; Yuya Nagai; Masahiro Kawahara; Masayuki Kobayashi; Hiroshi Kondoh; Naoko Misawa; Yoshio Koyanagi; Takashi Uchiyama; Akifumi Takaori-Kondo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2010, Peer-reviewed

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• MDM2 is a novel E3 ligase for HIV-1 Vif

  Taisuke Izumi; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hiroaki Higashitsuji; Katsuhiko Itoh; Katsuhiro Io; Masashi Matsui; Kazuhiro Iwai; Hiroshi Kondoh; Toshihiro Sato; Mitsunori Tomonaga; Satoru Ikeda; Hirofumi Akari; Yoshio Koyanagi; Jun Fujita; Takashi Uchiyama

  RETROVIROLOGY, Jan. 2009, Peer-reviewed

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• Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif

  Kotaro Shirakawa; Akifumi Takaori-Kondo; Masaru Yokoyama; Taisuke Izumi; Masashi Matsui; Katsuhiro Io; Toshihiro Sato; Hironori Sato; Takashi Uchiyama

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Nov. 2008, Peer-reviewed

  
• Cytidine deaminases as a weapon against retroviruses and a new target for antiviral therapy

  Taisuke Izumi; Kotaro Shirakawa; Akifumi Takaori-Kondo

  MINI-REVIEWS IN MEDICINAL CHEMISTRY, Mar. 2008, Peer-reviewed

  
• Dual effect of APOBEC3G on Hepatitis B virus

  Chiemi Noguchi; Nobuhiko Hiraga; Nami Mori; Masataka Tsuge; Michio Imamura; Shoichi Takahashi; Yoshifumi Fujimoto; Hidenori Ochi; Hiromi Abe; Toshiro Maekawa; Hiromi Yatsuji; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kazuaki Chayama

  JOURNAL OF GENERAL VIROLOGY, Feb. 2007, Peer-reviewed

  
• Murine retrovirus escapes from murine APOBEC3 via two distinct novel mechanisms

  Aierken Abudu; Akifumi Takaori-Kondo; Taisuke Izumi; Kotaro Shirakawa; Masayuki Kobayashi; Amane Sasada; Keiko Fukunaga; Takashi Uchiyama

  CURRENT BIOLOGY, Aug. 2006, Peer-reviewed

  
• Ubiquitination of APOBEC3 proteins by the Vif-Cullin5-ElonginB-ElonginC complex

  K Shirakawa; A Takaori-Kondo; M Kobayashi; M Tomonaga; T Izumi; K Fukunaga; A Sasada; A Abudu; Y Miyauchi; H Akari; K Iwai; T Uchiyama

  VIROLOGY, Jan. 2006, Peer-reviewed

  
• APOBEC3G targets human T-cell leukemia virus type 1

  A Sasada; A Takaori-Kondo; K Shirakawa; M Kobayashi; A Abudu; M Hishizawa; K Imada; Y Tanaka; T Uchiyama

  RETROVIROLOGY, May 2005, Peer-reviewed

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• [Analyses of the allogeneic stem cell transplantation outcome based on the new risk classification].

  Wake A; Shirakawa K; Kamio M; Yamasaki Y; Sawada H; Izumi Y

  Rinsho Ketsueki., Jan. 2004, Peer-reviewed

  
• ILF2 enhances the DNA cytosine deaminase activity of tumor mutator APOBEC3B in multiple myeloma cells

  Yasuhiro Kazuma; Kotaro Shirakawa; Yusuke Tashiro; Hiroyuki Yamazaki; Ryosuke Nomura; Yoshihito Horisawa; Suguru Takeuchi; Emani Stanford; Yoshinobu Konishi; Hiroyuki Matsui; Tadahiko Matsumoto; Fumiko Tanabe; Ryo Morishita; Shinji Ito; Akifumi Takaori-Kondo

  Scientific Reports, Dec. 2022, Peer-reviewed

  
• Characterization of the immune resistance of SARS-CoV-2 Mu variant and the robust immunity induced by Mu infection

  Keiya Uriu; Paúl Cárdenas; Erika Muñoz; Veronica Barragan; Yusuke Kosugi; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kei Sato

  The Journal of Infectious Diseases, 18 Feb. 2022, Peer-reviewed

  
• Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation

  Akatsuki Saito; Takashi Irie; Rigel Suzuki; Tadashi Maemura; Hesham Nasser; Keiya Uriu; Yusuke Kosugi; Kotaro Shirakawa; Kenji Sadamasu; Izumi Kimura; Jumpei Ito; Jiaqi Wu; Kiyoko Iwatsuki-Horimoto; Mutsumi Ito; Seiya Yamayoshi; Samantha Loeber; Masumi Tsuda; Lei Wang; Seiya Ozono; Erika P. Butlertanaka; Yuri L. Tanaka; Ryo Shimizu; Kenta Shimizu; Kumiko Yoshimatsu; Ryoko Kawabata; Takemasa Sakaguchi; Kenzo Tokunaga; Isao Yoshida; Hiroyuki Asakura; Mami Nagashima; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Kazuhisa Yoshimura; Akifumi Takaori-Kondo; Masaki Imai; Mika Chiba; Hirotake Furihata; Haruyo Hasebe; Kazuko Kitazato; Haruko Kubo; Naoko Misawa; Nanami Morizako; Kohei Noda; Akiko Oide; Mai Suganami; Miyoko Takahashi; Kana Tsushima; Miyabishara Yokoyama; Yue Yuan; Shinya Tanaka; So Nakagawa; Terumasa Ikeda; Takasuke Fukuhara; Yoshihiro Kawaoka; Kei Sato

  Nature, 10 Feb. 2022, Peer-reviewed

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• Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

  Bo Meng; Adam Abdullahi; Isabella A. T. M. Ferreira; Niluka Goonawardane; Akatsuki Saito; Izumi Kimura; Daichi Yamasoba; Pehuén Pereyra Gerber; Saman Fatihi; Surabhi Rathore; Samantha K. Zepeda; Guido Papa; Steven A. Kemp; Terumasa Ikeda; Mako Toyoda; Toong Seng Tan; Jin Kuramochi; Shigeki Mitsunaga; Takamasa Ueno; Kotaro Shirakawa; Akifumi Takaori-Kondo; Teresa Brevini; Donna L. Mallery; Oscar J. Charles; Stephen Baker; Gordon Dougan; Christoph Hess; Nathalie Kingston; Paul J. Lehner; Paul A. Lyons; Nicholas J. Matheson; Willem H. Owehand; Caroline Saunders; Charlotte Summers; James E. D. Thaventhiran; Mark Toshner; Michael P. Weekes; Patrick Maxwell; Ashley Shaw; Ashlea Bucke; Jo Calder; Laura Canna; Jason Domingo; Anne Elmer; Stewart Fuller; Julie Harris; Sarah Hewitt; Jane Kennet; Sherly Jose; Jenny Kourampa; Anne Meadows; Criona O’Brien; Jane Price; Cherry Publico; Rebecca Rastall; Carla Ribeiro; Jane Rowlands; Valentina Ruffolo; Hugo Tordesillas; Ben Bullman; Benjamin J. Dunmore; Stuart Fawke; Stefan Gräf; Josh Hodgson; Christopher Huang; Kelvin Hunter; Emma Jones; Ekaterina Legchenko; Cecilia Matara; Jennifer Martin; Federica Mescia; Ciara O’Donnell; Linda Pointon; Joy Shih; Rachel Sutcliffe; Tobias Tilly; Carmen Treacy; Zhen Tong; Jennifer Wood; Marta Wylot; Ariana Betancourt; Georgie Bower; Chiara Cossetti; Aloka De Sa; Madeline Epping; Stuart Fawke; Nick Gleadall; Richard Grenfell; Andrew Hinch; Sarah Jackson; Isobel Jarvis; Ben Krishna; Francesca Nice; Ommar Omarjee; Marianne Perera; Martin Potts; Nathan Richoz; Veronika Romashova; Luca Stefanucci; Mateusz Strezlecki; Lori Turner; Eckart M. D. D. De Bie; Katherine Bunclark; Masa Josipovic; Michael Mackay; John Allison; Helen Butcher; Daniela Caputo; Debbie Clapham-Riley; Eleanor Dewhurst; Anita Furlong; Barbara Graves; Jennifer Gray; Tasmin Ivers; Emma Le Gresley; Rachel Linger; Sarah Meloy; Francesca Muldoon; Nigel Ovington; Sofia Papadia; Isabel Phelan; Hannah Stark; Kathleen E. Stirrups; Paul Townsend; Neil Walker; Jennifer Webster; Ingrid Scholtes; Sabine Hein; Rebecca King; Erika P. Butlertanaka; Yuri L. Tanaka; Terumasa Ikeda; Jumpei Ito; Keiya Uriu; Yusuke Kosugi; Mai Suganami; Akiko Oide; Miyabishara Yokoyama; Mika Chiba; Chihiro Motozono; Hesham Nasser; Ryo Shimizu; Yue Yuan; Kazuko Kitazato; Haruyo Hasebe; So Nakagawa; Jiaqi Wu; Miyoko Takahashi; Takasuke Fukuhara; Kenta Shimizu; Kana Tsushima; Haruko Kubo; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Kayoko Nagata; Yugo Kawai; Yohei Yanagida; Yusuke Tashiro; Kenzo Tokunaga; Seiya Ozono; Ryoko Kawabata; Nanami Morizako; Kenji Sadamasu; Hiroyuki Asakura; Mami Nagashima; Kazuhisa Yoshimura; Paúl Cárdenas; Erika Muñoz; Veronica Barragan; Sully Márquez; Belén Prado-Vivar; Mónica Becerra-Wong; Mateo Caravajal; Gabriel Trueba; Patricio Rojas-Silva; Michelle Grunauer; Bernardo Gutierrez; Juan José Guadalupe; Juan Carlos Fernández-Cadena; Derly Andrade-Molina; Manuel Baldeon; Andrea Pinos; John E. Bowen; Anshu Joshi; Alexandra C. Walls; Laurelle Jackson; Darren Martin; Kenneth G. C. Smith; John Bradley; John A. G. Briggs; Jinwook Choi; Elo Madissoon; Kerstin Meyer; Petra Mlcochova; Lourdes Ceron-Gutierrez; Rainer Doffinger; Sarah A. Teichmann; Andrew J. Fisher; Matteo S. Pizzuto; Anna de Marco; Davide Corti; Myra Hosmillo; Joo Hyeon Lee; Leo C. James; Lipi Thukral; David Veesler; Alex Sigal; Fotios Sampaziotis; Ian G. Goodfellow; Nicholas J. Matheson; Kei Sato; Ravindra K. Gupta

  Nature, 01 Feb. 2022, Peer-reviewed

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• Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

  Rigel Suzuki; Daichi Yamasoba; Izumi Kimura; Lei Wang; Mai Kishimoto; Jumpei Ito; Yuhei Morioka; Naganori Nao; Hesham Nasser; Keiya Uriu; Yusuke Kosugi; Masumi Tsuda; Yasuko Orba; Michihito Sasaki; Ryo Shimizu; Ryoko Kawabata; Kumiko Yoshimatsu; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Mai Suganami; Akiko Oide; Mika Chiba; Hayato Ito; Tomokazu Tamura; Kana Tsushima; Haruko Kubo; Zannatul Ferdous; Hiromi Mouri; Miki Iida; Keiko Kasahara; Koshiro Tabata; Mariko Ishizuka; Asako Shigeno; Kenzo Tokunaga; Seiya Ozono; Isao Yoshida; So Nakagawa; Jiaqi Wu; Miyoko Takahashi; Atsushi Kaneda; Motoaki Seki; Ryoji Fujiki; Bahityar Rahmutulla Nawai; Yutaka Suzuki; Yukie Kashima; Kazumi Abe; Kiyomi Imamura; Kotaro Shirakawa; Akifumi Takaori-Kondo; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Kayoko Nagata; Yugo Kawai; Yohei Yanagida; Yusuke Tashiro; Otowa Takahashi; Kazuko Kitazato; Haruyo Hasebe; Chihiro Motozono; Mako Toyoda; Toong Seng Tan; Isaac Ngare; Takamasa Ueno; Akatsuki Saito; Erika P. Butlertanaka; Yuri L. Tanaka; Nanami Morizako; Hirofumi Sawa; Terumasa Ikeda; Takashi Irie; Keita Matsuno; Shinya Tanaka; Takasuke Fukuhara; Kei Sato

  Nature, 01 Feb. 2022, Peer-reviewed

  
• The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance

  Izumi Kimura; Yusuke Kosugi; Jiaqi Wu; Jiri Zahradnik; Daichi Yamasoba; Erika P. Butlertanaka; Yuri L. Tanaka; Keiya Uriu; Yafei Liu; Nanami Morizako; Kotaro Shirakawa; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Kenzo Tokunaga; Takamasa Ueno; Akifumi Takaori-Kondo; Gideon Schreiber; Hisashi Arase; Chihiro Motozono; Akatsuki Saito; So Nakagawa; Kei Sato

  Cell Reports, Jan. 2022, Peer-reviewed

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• Neutralization of the SARS-CoV-2 Mu Variant by Convalescent and Vaccine Serum

  Keiya Uriu; Izumi Kimura; Kotaro Shirakawa; Akifumi Takaori-Kondo; Taka-aki Nakada; Atsushi Kaneda; So Nakagawa; Kei Sato

  New England Journal of Medicine, 16 Dec. 2021, Peer-reviewed

  
• SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion

  Petra Mlcochova; Steven A. Kemp; Mahesh Shanker Dhar; Guido Papa; Bo Meng; Isabella A. T. M. Ferreira; Rawlings Datir; Dami A. Collier; Anna Albecka; Sujeet Singh; Rajesh Pandey; Jonathan Brown; Jie Zhou; Niluka Goonawardane; Swapnil Mishra; Charles Whittaker; Thomas Mellan; Robin Marwal; Meena Datta; Shantanu Sengupta; Kalaiarasan Ponnusamy; Venkatraman Srinivasan Radhakrishnan; Adam Abdullahi; Oscar Charles; Partha Chattopadhyay; Priti Devi; Daniela Caputo; Tom Peacock; Chand Wattal; Neeraj Goel; Ambrish Satwik; Raju Vaishya; Meenakshi Agarwal; Himanshu Chauhan; Tanzin Dikid; Hema Gogia; Hemlata Lall; Kaptan Verma; Mahesh Shanker Dhar; Manoj K. Singh; Namita Soni; Namonarayan Meena; Preeti Madan; Priyanka Singh; Ramesh Sharma; Rajeev Sharma; Sandhya Kabra; Sattender Kumar; Swati Kumari; Uma Sharma; Urmila Chaudhary; Sridhar Sivasubbu; Vinod Scaria; J. K. Oberoi; Reena Raveendran; S. Datta; Saumitra Das; Arindam Maitra; Sreedhar Chinnaswamy; Nidhan Kumar Biswas; Ajay Parida; Sunil K. Raghav; Punit Prasad; Apurva Sarin; Satyajit Mayor; Uma Ramakrishnan; Dasaradhi Palakodeti; Aswin Sai Narain Seshasayee; K. Thangaraj; Murali Dharan Bashyam; Ashwin Dalal; Manoj Bhat; Yogesh Shouche; Ajay Pillai; Priya Abraham; Varsha Atul Potdar; Sarah S. Cherian; Anita Sudhir Desai; Chitra Pattabiraman; M. V. Manjunatha; Reeta S. Mani; Gautam Arunachal Udupi; Vinay Nandicoori; Karthik Bharadwaj Tallapaka; Divya Tej Sowpati; Ryoko Kawabata; Nanami Morizako; Kenji Sadamasu; Hiroyuki Asakura; Mami Nagashima; Kazuhisa Yoshimura; Jumpei Ito; Izumi Kimura; Keiya Uriu; Yusuke Kosugi; Mai Suganami; Akiko Oide; Miyabishara Yokoyama; Mika Chiba; Akatsuki Saito; Erika P. Butlertanaka; Yuri L. Tanaka; Terumasa Ikeda; Chihiro Motozono; Hesham Nasser; Ryo Shimizu; Yue Yuan; Kazuko Kitazato; Haruyo Hasebe; So Nakagawa; Jiaqi Wu; Miyoko Takahashi; Takasuke Fukuhara; Kenta Shimizu; Kana Tsushima; Haruko Kubo; Kotaro Shirakawa; Yasuhiro Kazuma; Ryosuke Nomura; Yoshihito Horisawa; Akifumi Takaori-Kondo; Kenzo Tokunaga; Seiya Ozono; Stephen Baker; Gordon Dougan; Christoph Hess; Nathalie Kingston; Paul J. Lehner; Paul A. Lyons; Nicholas J. Matheson; Willem H. Owehand; Caroline Saunders; Charlotte Summers; James E. D. Thaventhiran; Mark Toshner; Michael P. Weekes; Patrick Maxwell; Ashley Shaw; Ashlea Bucke; Jo Calder; Laura Canna; Jason Domingo; Anne Elmer; Stewart Fuller; Julie Harris; Sarah Hewitt; Jane Kennet; Sherly Jose; Jenny Kourampa; Anne Meadows; Criona O’Brien; Jane Price; Cherry Publico; Rebecca Rastall; Carla Ribeiro; Jane Rowlands; Valentina Ruffolo; Hugo Tordesillas; Ben Bullman; Benjamin J. Dunmore; Stuart Fawke; Stefan Gräf; Josh Hodgson; Christopher Huang; Kelvin Hunter; Emma Jones; Ekaterina Legchenko; Cecilia Matara; Jennifer Martin; Federica Mescia; Ciara O’Donnell; Linda Pointon; Nicole Pond; Joy Shih; Rachel Sutcliffe; Tobias Tilly; Carmen Treacy; Zhen Tong; Jennifer Wood; Marta Wylot; Laura Bergamaschi; Ariana Betancourt; Georgie Bower; Chiara Cossetti; Aloka De Sa; Madeline Epping; Stuart Fawke; Nick Gleadall; Richard Grenfell; Andrew Hinch; Oisin Huhn; Sarah Jackson; Isobel Jarvis; Ben Krishna; Daniel Lewis; Joe Marsden; Francesca Nice; Georgina Okecha; Ommar Omarjee; Marianne Perera; Martin Potts; Nathan Richoz; Veronika Romashova; Natalia Savinykh Yarkoni; Rahul Sharma; Luca Stefanucci; Jonathan Stephens; Mateusz Strezlecki; Lori Turner; Eckart M. D. D. De Bie; Katherine Bunclark; Masa Josipovic; Michael Mackay; Sabrina Rossi; Mayurun Selvan; Sarah Spencer; Cissy Yong; John Allison; Helen Butcher; Daniela Caputo; Debbie Clapham-Riley; Eleanor Dewhurst; Anita Furlong; Barbara Graves; Jennifer Gray; Tasmin Ivers; Mary Kasanicki; Emma Le Gresley; Rachel Linger; Sarah Meloy; Francesca Muldoon; Nigel Ovington; Sofia Papadia; Isabel Phelan; Hannah Stark; Kathleen E. Stirrups; Paul Townsend; Neil Walker; Jennifer Webster; Ingrid Scholtes; Sabine Hein; Rebecca King; Antranik Mavousian; Joo Hyeon Lee; Jessica Bassi; Chiara Silacci-Fegni; Christian Saliba; Dora Pinto; Takashi Irie; Isao Yoshida; William L. Hamilton; Kei Sato; Samir Bhatt; Seth Flaxman; Leo C. James; Davide Corti; Luca Piccoli; Wendy S. Barclay; Partha Rakshit; Anurag Agrawal; Ravindra K. Gupta

  Nature, 04 Nov. 2021, Peer-reviewed

  

Misc.

• Antiviral humoral immunity against SARS-CoV-2 omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive and XBB-infected individuals

  Yusuke Kosugi; Yu Kaku; Alfredo A. Hinay; Ziyi Guo; Keiya Uriu; Minoru Kihara; Fumitake Saito; Yoshifumi Uwamino; Jin Kuramochi; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kei Sato

  The Lancet Infectious Diseases, Mar. 2024

  
• Interactome Analysis of APOBEC3B in Multiple Myeloma

  Yasuhiro Kazuma; Kotaro Shirakawa; Anamaria Daniela Sarca; Yoshihito Horisawa; Hirofumi Fukuda; Hiroyuki Matsui; Hiroyuki Yamazaki; Tadahiko Matsumoto; Fumiko Tanabe; Ryo Morishita; Shinji Ito; Akifumi Takaori-Kondo

  BLOOD, Nov. 2019

  
• Selective HDAC3 Inhibition Induces Apoptosis in B Cell Lymphoma through Protein Acetylation

  Hiroyuki Matsui; Kotaro Shirakawa; Hsin-Yi Chang; Anamaria Daniela Sarca; Yasuhiro Kazuma; Hirofumi Fukuda; Hiroyuki Yamazaki; Tadahiko Matsumoto; Yasushi Ishihama; Akifumi Takaori-Kondo

  BLOOD, Nov. 2018

  
• PKA-Mediated Phosphorylation of APOBEC3B Suppresses Its DNA Mutagenic Potential in Myeloma Cells

  Tadahiko Matsumoto; Kotaro Shirakawa; Hiroyuki Matsui; Hiroyuki Yamazaki; Yasuhiro Kazuma; Anamaria Daniela Sarca; Hirofumi Fukuda; Wataru Maruyama; Akifumi Takaori-Kondo

  BLOOD, Dec. 2016

  
• Alternative Splicing of APOBEC3D Generates Functional Diversity and Its Role As a DNA Mutator

  Hisashi Takei; Masanori Fujii; Sohei Nakayama; Ikei Kobayashi; Keisuke Shindo; Kotaro Shirakawa; Akifumi Takaori-Kondo; Susumu Kobayashi

  BLOOD, Dec. 2016

  
• Aberrantly Expressed APOBEC3B Induces Mutations in Multiple Myeloma

  Hiroyuki Yamazaki; Kotaro Shirakawa; Tadahiko Matsumoto; Hiroyuki Matsui; Wataru Maruyama; Masayuki Kobayashi; Keisuke Shindo; Anamaria Daniela Sarca; Masaki Ri; Shinsuke Iida; Akifumi Takaori-Kondo

  BLOOD, Dec. 2016

  
• APOBEC3GのN末端ドメインの構造的洞察による,RNA結合に重要なアミノ酸残基の同定

  福田寛文; SARCA Daniela; 山下和男; LI Songling; STANDLEY Daron; LI Songling; STANDLEY Daron; 白川康太郎; 高折晃史; 泉泰輔

  日本エイズ学会誌, 20 Nov. 2016

  
• リンパ腫合併症例に対する自家末梢血幹細胞移植のHIV‐1プロウイルス量および潜伏感染リザーバーサイズへの影響

  吉永則良; 白川康太郎; 福田寛文; 新堂啓祐; 小林正行; 高折晃史

  日本エイズ学会誌, 20 Nov. 2016

  
• PPP2R5DはVifユビキチンリガーゼの基質であり,Vifの誘導する細胞周期停止に関わっている

  永田佳代子; 新堂啓祐; 松井佑亮; 白川康太郎; 高折晃史

  日本エイズ学会誌, 20 Nov. 2016

  
• HDACiによるshock and kill

  白川康太郎

  日本エイズ学会誌, 20 Nov. 2016

  
• 極めて急速な臨床経過をたどったcMYC/IGH,BCL2/IGH,PAX5/IGH転座を有するtriple‐hit lymphomaの一例

  大塚泰幸; 白川康太郎; 錦織桃子; 菱澤方勝; 北野俊行; 羽賀博典; 高折晃史

  日本リンパ網内系学会会誌, 05 Aug. 2016

  
• Picture in Clinical Hematology No. 96

  松井佑亮; 新堂啓祐; 小林正行; 白川康太郎; 近藤忠一; 高折晃史

  臨床血液, 2016

  
• βヒドロキシ酪酸は内在性のHDAC阻害剤として酸化ストレス抑制に関わる

  島津忠広; 白川康太郎; VERDIN Eric

  日本薬学会年会要旨集(CD-ROM), 2016

  
• βヒドロキシ酪酸による酸化ストレス制御と疾患

  白川康太郎

  日本抗加齢医学会総会プログラム・抄録集, 2016

  
• Vifの誘導する細胞周期G2停止機構の探求

  永田佳代子; 新堂啓祐; 松井佑亮; 白川康太郎; 小林正行; 高折晃史

  日本エイズ学会誌, 20 Nov. 2015

  
• APOBEC3Gのアセチル化修飾と機能調節

  福田寛文; 松井佑亮; 白川康太郎; 和田典也; 宮川敬; 梁明秀; 高折晃史

  日本エイズ学会誌, 20 Nov. 2015

  
• SIRT1 deacetylates ROR gamma t and enhances Th17 cell generation (vol 212, pg 607, 2015)

  Hyung W. Lim; Seung Goo Kang; Jae Kyu Ryu; Birgit Schilling; Mingjian Fei; Intelly S. Lee; Amanuel Kehasse; Kotaro Shirakawa; Masaru Yokoyama; Martina Schnlzer; Herbert G. Kasler; Hye-Sook Kwon; Bradford W. Gibson; Hironori Sato; Katerina Akassoglou; Changchun Xiao; Dan R. Littman; Melanie Ott; Eric Verdin

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 2015

  
• ATLにおけるTDP1の発現低下は転写因子NRF1がHBZによって障害されていることに起因する

  小林正行; 瀧内曜子; 多田浩平; 岩井文絵; 櫻田麻希; 菱澤方勝; 白川康太郎; 新堂啓祐; 安永純一朗; 武田俊一; POMMIER Yves; 松岡雅雄; 高折晃史

  日本HTLV‐1学会学術集会, 2015

  
• Successful treatment with recombinant thrombomodulin for disseminated intravascular coagulation complicated with hemophagocytic syndrome

  YAMAZAKI HIROYUKI; KONDO TADAKAZU; TATSUMI GOICHI; KOTANI SHIN'ICHI; ARAI YASUYUKI; SHIRAKAWA KOTARO; KITANO TOSHIYUKI; HISHIZAWA MASAKATSU; KADOWAKI NORIMITSU; TAKAORI AKIFUMI

  臨床血液, 2015

  
• Expression of Tim-1 and Its Pathogenetic Role in Primary CNS Lymphoma

  Momoko Nishikori; Wataru Kishimoto; Hiroshi Arima; Kotaro Shirakawa; Toshio Kitawaki; Akifumi Takaori-Kondo

  BLOOD, Dec. 2014

  
• CBFβはMDM2によるVifの分解を阻害することでVifを安定化する

  MATSUI YUSUKE; SHINDO KEISUKE; NAGATA KAYOKO; YOSHINAGA NORIYOSHI; MARUYAMA WATARU; SHIRAKAWA KOTARO; KOBAYASHI MASAYUKI; TAKAORI AKIFUMI

  日本エイズ学会誌, 20 Nov. 2014

  
• HIV潜伏感染細胞の研究の最前線

  SHIRAKAWA KOTARO

  日本エイズ学会誌, 20 Nov. 2014

  
• HIVの潜伏感染とその根絶への仮説的戦略

  SHIRAKAWA KOTARO; TAKAORI AKIFUMI

  HIV感染症とAIDSの治療, 20 May 2014

  
• HIV感染症2013~現状と展望~3.潜伏感染とそれを標的とした新規治療について

  SHIRAKAWA KOTARO

  血液フロンティア, 30 May 2013

  
• HIV‐1Vifはp53を介してその機能を発揮する

  IZUMI YASUSUKE; SHIRAKAWA KOTARO; MATSUI MASASHI; IO KATSUHIRO; SHINOHARA MASANOBU; UCHIYAMA TAKASHI; TAKAORI AKIFUMI

  日本エイズ学会誌, 20 Nov. 2009

  
• HIV‐1 Vifはp53を介してその機能を発揮する

  IZUMI TAISUKE; SHIRAKAWA KOTARO; MATSUI MASASHI; IO KATSUHIRO; SHINOHARA MASANOBU; UCHIYAMA TAKASHI; TAKAORI AKIFUMI

  日本ウイルス学会学術集会プログラム・抄録集, 01 Oct. 2009

  
• 分子モデリングによるリン酸化APOBEC3Gの構造解析

  YOKOYAMA MASARU; SHIRAKAWA KOTARO; TAKAORI KOJI; SATO HIRONORI

  日本エイズ学会誌, 20 Nov. 2008

  
• Protein Kinase Aによるリン酸化はAPOBEC3GとVifの相互作用を調節する

  SHIRAKAWA KOTARO; TAKAORI KOJI; YOKOYAMA MASARU; MATSUI MICHISHI; IO KATSUHIRO; IZUMI TAISUKE; SATO HIRONORI; UCHIYAMA TAKASHI

  日本エイズ学会誌, 20 Nov. 2008

  
• HIV‐1 Vifはp53依存的経路で感染細胞の細胞周期をG2/M期に停止させる

  IZUMI TAISUKE; TAKAORI KOJI; SHIRAKAWA KOTARO; MATSUI MICHISHI; IO KATSUHIRO; UCHIYAMA TAKASHI

  日本エイズ学会誌, 20 Nov. 2008

  
• HLA一致同胞以外をドナーとしたミニ移植の検討

  白川 康太郎; 石川 隆之; 一戸 辰夫; 吉岡 聡; 鷹尾 珠美子; 門脇 則光; 高折 晃史; 今田 和典; 堀 利行; 岡崎 俊朗; 内山 卓

  日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2004

  

Awards

• 02 May 2010

  Graduate School of Medicine, Kyoto Unversity, Young Inevstigator Award

External funds: Kakenhi

• Transcriptome analysis of HIV-1 latently infected cells

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49060:Virology-related

  Kyoto University

  Kotaro Shirakawa

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  HIV潜伏感染;トランスクリプトーム;CRISPRスクリーニング;mTOR経路;HIV感染症;潜伏感染;再活性化;CRISPRスクリーン;HIV-1;CAGE法;CRISPR/Cas9;トランスクリプトーム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07591/
• APOBEC3B-induced genome mutations and its contribution to clonal evolution in cancers

  Grant-in-Aid for Scientific Research (B)

  Basic Section 50010:Tumor biology-related

  Kyoto University

  Akifumi Takaori-Kondo

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  APOBEC;がん;クローン進化;ゲノム変異;シチジン脱アミノ化;C-to-T変異;APOBEC3;癌のクローン進化;癌の多様性;治療抵抗性;マウスモデル;APOBEC signature;CAGE法;シングルセル解析;癌の不均一性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03502/
• Comprehensive enhancer analysis and molecular pathogenesis of leukemia using our novel technology

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Institute of Physical and Chemical Research

  Yasuhiro Murakawa

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  白血病;エンハンサー;ゲノム解析技術;バイオマーカー;転写ネットワーク;NET-CAGE;造血器悪性腫瘍;ヒトゲノム科学;ノンコーディングゲノム・RNA;次世代シークエンシング;バイオインフォマティクス;ゲノム科学;遺伝子発現制御;次世代シークエンサー;造血器腫瘍;NET-CAGE法;腫瘍;ゲノム解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03992/
• Role of A3G acetylation and Vif/HDAC3 complex in HIV-1 infection

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kotaro Shirakawa

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  HIV-1;Vif;ヒストン脱アセチル化酵素;DNAシトシン脱アミノ化酵素APOBEC3G;潜伏感染;HIV感染症;HIV-1 Vif;APOBEC3G;アセチル化;HDAC3;シチジン脱アミノ化酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08809/
• CRISPR screen to identify novel molecular mechanisms of HIV-1 latency

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49060:Virology-related

  Kyoto University

  白川 康太郎

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  HIV;潜伏感染;shock and kill;潜伏感染再活性化薬;HIV感染症根治療法;HIV感染症;CRISPRスクリーン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07085/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  The Outline of Host Defense

  3220, Spring, Faculty of Medicine, 2