Basic Information

Faculty

• Faculty of Medicine

Email Address

• Email Address

  midorikawa.mitsuharu.3ykyoto-u.ac.jp

Professional Memberships

• 日本神経科学学会
• 日本生理学会

Academic Degree

• 18 Apr. 2007

  東京大学博士（心理学）
• 31 Mar. 2003

  東京大学修士（心理学）

Academic Resume (Undergraduate School/Majors)

• 東京大学, 文学部行動文化学科, 卒業

Research History

• From Apr. 2023, To Present

  Kyoto University, Graduate School of Medicine, Human Health Sciences, Professor
• From May 2022, To Mar. 2023

  Tokyo Women's Medical University, 医学部 生理学（神経生理学分野）, Associate Professor
• From Jun. 2020, To Apr. 2022

  東京女子医科大学, 医学部 生理学（神経生理学分野）, 講師
• From Oct. 2017, To May 2020

  Tokyo Women's Medical University, 医学部 生理学（神経生理学分野）, 准講師
• From Apr. 2012, To Sep. 2017

  Doshisha University, Graduate School of Brain Science, 助教
• From Jun. 2007, To Mar. 2012

  オレゴン健康科学大学, ヴォラム研究所, ポスドク

ID,URL

• J-Global ID

  201201039804664812

• External link

  https://midorikawalab.wixsite.com/midorikawa-lab

researchmap URL

• https://researchmap.jp/7000002617

Research

Research Interests

• 開口放出
• パッチクランプ
• 蛍光イメージング
• シナプス前部
• シナプス小胞
• 生理学
• 神経科学

Research Areas

• Life sciences, Physiology
• Life sciences, Neuroscience - general
• Life sciences, Cell biology
• Life sciences, Metabolism and endocrinology
• Life sciences, Nervous system function

Papers

• Developmental refinement of the active zone nanotopography and axon wiring at the somatosensory thalamus.

  Mitsuharu Midorikawa; Hirokazu Sakamoto; Yukihiro Nakamura; Kenzo Hirose; Mariko Miyata

  Cell Reports, Oct. 2024, Peer-reviewed, Lead author, Corresponding author

  
• Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodeling

  Walter A; Uesaka N; Midorikawa M

  Frontiers in Cellular Neuroscience, May 2023, Peer-reviewed, Invited, Corresponding author

  
• Developmental and activity-dependent modulation of coupling distance between release site and Ca2+ channel.

  Mitsuharu Midorikawa

  Frontiers in Cellular Neuroscience, Oct. 2022, Peer-reviewed, Lead author, Last author, Corresponding author

  
• Pathway-specific maturation of presynaptic functions of the somatosensory thalamus

  Mitsuharu Midorikawa

  Neuroscience Research, May 2022, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Dysfunction of parvalbumin-expressing cells in the thalamic reticular nucleus induces cortical spike-and-wave discharges and an unconscious state

  Manal S. Abdelaal; Mitsuharu Midorikawa; Toru Suzuki; Kenta Kobayashi; Norio Takata; Mariko Miyata; Masaru Mimura; Kenji F. Tanaka

  Brain Communications, 01 Mar. 2022, Peer-reviewed

  
• Distinct functional developments of surviving and eliminated presynaptic terminals.

  Mitsuharu Midorikawa; Mariko Miyata

  Proceedings of the National Academy of Sciences of the United States of America, 16 Mar. 2021, Peer-reviewed, Lead author, Corresponding author

  
• Direct imaging of rapid tethering of synaptic vesicles accompanying exocytosis at a fast central synapse.

  Takafumi Miki; Mitsuharu Midorikawa; Takeshi Sakaba

  Proceedings of the National Academy of Sciences of the United States of America, 08 Jun. 2020, Peer-reviewed

  
• Real-time imaging of synaptic vesicle exocytosis by total internal reflection fluorescence (TIRF) microscopy.

  Mitsuharu Midorikawa

  Neuroscience research, Nov. 2018, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Kinetics of Releasable Synaptic Vesicles and Their Plastic Changes at Hippocampal Mossy Fiber Synapses.

  Mitsuharu Midorikawa; Takeshi Sakaba

  Neuron, 06 Dec. 2017, Peer-reviewed, Lead author, Corresponding author

  
• Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice.

  Yuji Okamoto; Noa Lipstein; Yunfeng Hua; Kun-Han Lin; Nils Brose; Takeshi Sakaba; Mitsuharu Midorikawa

  eLife, 07 May 2016, Peer-reviewed, Last author, Corresponding author

  
• Imaging Exocytosis of Single Synaptic Vesicles at a Fast CNS Presynaptic Terminal.

  Mitsuharu Midorikawa; Takeshi Sakaba

  Neuron, 04 Nov. 2015, Peer-reviewed, Lead author, Corresponding author

  
• Developmental changes in Ca2+ channel subtypes regulating endocytosis at the calyx of Held.

  Mitsuharu Midorikawa; Yuji Okamoto; Takeshi Sakaba

  The Journal of physiology, 15 Aug. 2014, Peer-reviewed, Lead author, Corresponding author

  
• Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers.

  M K Knowles; S Barg; L Wan; M Midorikawa; X Chen; Wolfhard Almers

  Proceedings of the National Academy of Sciences of the United States of America, 30 Nov. 2010, Peer-reviewed

  
• Syntaxin clusters assemble reversibly at sites of secretory granules in live cells.

  S Barg; M K Knowles; X Chen; M Midorikawa; Wolfhard Almers

  Proceedings of the National Academy of Sciences of the United States of America, 30 Nov. 2010, Peer-reviewed

  
• Different roles of ribbon-associated and ribbon-free active zones in retinal bipolar cells.

  Mitsuharu Midorikawa; Yoshihiko Tsukamoto; Ken Berglund; Masaaki Ishii; Masao Tachibana

  Nature neuroscience, Oct. 2007, Peer-reviewed, Lead author

  
• Increase in the pool size of releasable synaptic vesicles by the activation of protein kinase C in goldfish retinal bipolar cells.

  Ken Berglund; Mitsuharu Midorikawa; Masao Tachibana

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 15 Jun. 2002, Peer-reviewed

  

Misc.

• 超解像ライブイメージング解析による中枢神経シナプス前終末内のシナプス小胞動態計測

  緑川光春

  雑誌「細胞」, Jan. 2022, Invited, Lead author, Corresponding author

  
• n/a

  Mitsuharu Midorikawa

  Precision Medicine, Sep. 2021, Invited, Lead author, Corresponding author

  
• 中枢神経シナプス前終末における小胞動態の超解像ライブイメージング

  緑川光春

  月刊「細胞 The CELL」12月号「マルチスケールな精神病態」, Dec. 2019, Invited, Lead author

  
• Coupling between Ca2+ channels and endocytosis at the calyx of Held

  Mitsuharu Midorikawa; Takeshi Sakaba

  JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013

  
• Syntaxin molecules reversibly assemble into clusters beneath secretory granules

  Michelle Knowles; Sebastian Barg; Wolfhard Almers; Lei Wan; Xi Chen; Mitsuharu Midorikawa

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2011

  
• Imaging the Disassembly of Syntxin Cluster during the Exocytosis of Single Secretory Granules

  Mitsuharu Midorikawa; Wolfhard Almers

  BIOPHYSICAL JOURNAL, Jan. 2010

  
• 網膜における一過性応答と持続性応答の発生機構

  立花政夫; 緑川光春; 塚本吉彦

  生化学, 2008

  
• Fusion sites of synaptic vesicles in goldfish retinal bipolar cells

  Mitsuharu Midorikawa; Masao Tachibana

  NEUROSCIENCE RESEARCH, 2006

  
• キンギョMb1型双極細胞におけるCa2+マイクロドメインと開口放出部位(Ca2+ microdomains and fusion sites of synaptic vesicles in goldfish retinal bipolar cells)

  緑川 光春; 浅香 知光; 立花 政夫

  神経化学, Aug. 2004

  
• 網膜双極細胞におけるシナプス小胞の配置に対するフォルボール・エステルの効果

  バーグランド健; 塚本吉彦; 緑川光春; 立花政夫

  日本神経科学大会プログラム・抄録集, 2001

  
• 網膜双極細胞におけるシナプス小胞の配置に対するフォルボール・エステルの効果

  バーグランド健; 塚本吉彦; 緑川光春; 立花政夫

  神経化学, 2001

  

Awards

• 29 Mar. 2018

  第19回日本生理学会奨励賞

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Sports Science II

  U102, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Sports Science II

  U102, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Practice in Rehabilitation Education I

  M622, Fall, Graduate School of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Community based Clinical Practice

  7241, Spring, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Human Health Sciences III

  3203, Fall, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Practice of Advanced Occupational Therapy

  7240, Year-long, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology Practice

  3241, Fall, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Human Health Sciences IV

  3204, Fall, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Medicine I (Neurophysiology )

  H163, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Medicine I (Physiology I)

  H154, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Essential Physiology II

  E062, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Occupational Therapy : Lecture

  M616, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Essential Physiology I

  E061, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Neurophysiology I

  3213, Fall, Faculty of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology II

  3211, Spring, Faculty of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology I

  3210, Spring, Faculty of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Neurophysiology

  3242, Fall, Faculty of Medicine, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Preliminary Clinical Practice

  7236, Year-long, Faculty of Medicine, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Graduate Research

  7229, Year-long, Faculty of Medicine, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Comprehensive Clinical Practice II

  7242, Spring, Faculty of Medicine, 9
• From 01 Apr. 2024, To 31 Mar. 2025

  Comprehensive Clinical Practice I

  7237, Fall, Faculty of Medicine, 9
• From 01 Apr. 2024, To 31 Mar. 2025

  Research on Advanced Rehabilitation

  M619, Year-long, Graduate School of Medicine, 8
• From 01 Apr. 2023, To 31 Mar. 2024

  Sports Science II

  U102, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Sports Science II

  U102, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology Practice

  3241, Fall, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Essential Physiology I

  E061, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Essential Physiology II

  E062, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Neurophysiology

  3242, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Neurophysiology I

  3213, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology II

  3211, Spring, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology I

  3210, Spring, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Graduate Research

  7229, Year-long, Faculty of Medicine, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Research on Advanced Rehabilitation

  M619, Year-long, Graduate School of Medicine, 8