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Midorikawa, Mitsuharu
Graduate School of Medicine, Department of Human Health Sciences Professor
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Last Updated :2026/08/20
Basic Information
Faculty
Email Address
Email Address
midorikawa.mitsuharu.3y
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Undergraduate School/Majors)
Research History
- From Apr. 2023, To PresentKyoto University, Graduate School of Medicine, Human Health Sciences, Professor
- From May 2022, To Mar. 2023Tokyo Women's Medical University, 医学部 生理学（神経生理学分野）, Associate Professor
- From Jun. 2020, To Apr. 2022東京女子医科大学, 医学部 生理学（神経生理学分野）, 講師
- From Oct. 2017, To May 2020Tokyo Women's Medical University, 医学部 生理学（神経生理学分野）, 准講師
- From Apr. 2012, To Sep. 2017Doshisha University, Graduate School of Brain Science, 助教
- From Jun. 2007, To Mar. 2012オレゴン健康科学大学, ヴォラム研究所, ポスドク
ID,URL
J-Global ID
External link
researchmap URL
list
Last Updated :2026/08/20
Research
Research Interests
Research Areas
- Life sciences, Physiology
- Life sciences, Neuroscience - general
- Life sciences, Cell biology
- Life sciences, Metabolism and endocrinology
- Life sciences, Nervous system function
Papers
- Developmental refinement of the active zone nanotopography and axon wiring at the somatosensory thalamus.Mitsuharu Midorikawa; Hirokazu Sakamoto; Yukihiro Nakamura; Kenzo Hirose; Mariko MiyataCell Reports, Oct. 2024, Peer-reviewed, Lead author, Corresponding author
- Editorial: Functional and molecular insights of neural circuit adaptation, refinement, and remodelingWalter A; Uesaka N; Midorikawa MFrontiers in Cellular Neuroscience, May 2023, Peer-reviewed, Invited, Corresponding author
- Developmental and activity-dependent modulation of coupling distance between release site and Ca2+ channel.Mitsuharu MidorikawaFrontiers in Cellular Neuroscience, Oct. 2022, Peer-reviewed, Lead author, Last author, Corresponding author
- Pathway-specific maturation of presynaptic functions of the somatosensory thalamusMitsuharu MidorikawaNeuroscience Research, May 2022, Peer-reviewed, Invited, Lead author, Last author, Corresponding author
- Dysfunction of parvalbumin-expressing cells in the thalamic reticular nucleus induces cortical spike-and-wave discharges and an unconscious stateManal S. Abdelaal; Mitsuharu Midorikawa; Toru Suzuki; Kenta Kobayashi; Norio Takata; Mariko Miyata; Masaru Mimura; Kenji F. TanakaBrain Communications, 01 Mar. 2022, Peer-reviewed
- Distinct functional developments of surviving and eliminated presynaptic terminals.Mitsuharu Midorikawa; Mariko MiyataProceedings of the National Academy of Sciences of the United States of America, 16 Mar. 2021, Peer-reviewed, Lead author, Corresponding author
- Direct imaging of rapid tethering of synaptic vesicles accompanying exocytosis at a fast central synapse.Takafumi Miki; Mitsuharu Midorikawa; Takeshi SakabaProceedings of the National Academy of Sciences of the United States of America, 08 Jun. 2020, Peer-reviewed
- Real-time imaging of synaptic vesicle exocytosis by total internal reflection fluorescence (TIRF) microscopy.Mitsuharu MidorikawaNeuroscience research, Nov. 2018, Peer-reviewed, Invited, Lead author, Last author, Corresponding author
- Kinetics of Releasable Synaptic Vesicles and Their Plastic Changes at Hippocampal Mossy Fiber Synapses.Mitsuharu Midorikawa; Takeshi SakabaNeuron, 06 Dec. 2017, Peer-reviewed, Lead author, Corresponding author
- Distinct modes of endocytotic presynaptic membrane and protein uptake at the calyx of Held terminal of rats and mice.Yuji Okamoto; Noa Lipstein; Yunfeng Hua; Kun-Han Lin; Nils Brose; Takeshi Sakaba; Mitsuharu MidorikawaeLife, 07 May 2016, Peer-reviewed, Last author, Corresponding author
- Imaging Exocytosis of Single Synaptic Vesicles at a Fast CNS Presynaptic Terminal.Mitsuharu Midorikawa; Takeshi SakabaNeuron, 04 Nov. 2015, Peer-reviewed, Lead author, Corresponding author
- Developmental changes in Ca2+ channel subtypes regulating endocytosis at the calyx of Held.Mitsuharu Midorikawa; Yuji Okamoto; Takeshi SakabaThe Journal of physiology, 15 Aug. 2014, Peer-reviewed, Lead author, Corresponding author
- Single secretory granules of live cells recruit syntaxin-1 and synaptosomal associated protein 25 (SNAP-25) in large copy numbers.M K Knowles; S Barg; L Wan; M Midorikawa; X Chen; Wolfhard AlmersProceedings of the National Academy of Sciences of the United States of America, 30 Nov. 2010, Peer-reviewed
- Syntaxin clusters assemble reversibly at sites of secretory granules in live cells.S Barg; M K Knowles; X Chen; M Midorikawa; Wolfhard AlmersProceedings of the National Academy of Sciences of the United States of America, 30 Nov. 2010, Peer-reviewed
- Different roles of ribbon-associated and ribbon-free active zones in retinal bipolar cells.Mitsuharu Midorikawa; Yoshihiko Tsukamoto; Ken Berglund; Masaaki Ishii; Masao TachibanaNature neuroscience, Oct. 2007, Peer-reviewed, Lead author
- Increase in the pool size of releasable synaptic vesicles by the activation of protein kinase C in goldfish retinal bipolar cells.Ken Berglund; Mitsuharu Midorikawa; Masao TachibanaThe Journal of neuroscience : the official journal of the Society for Neuroscience, 15 Jun. 2002, Peer-reviewed
Misc.
- 超解像ライブイメージング解析による中枢神経シナプス前終末内のシナプス小胞動態計測緑川光春雑誌「細胞」, Jan. 2022, Invited, Lead author, Corresponding author
- n/aMitsuharu MidorikawaPrecision Medicine, Sep. 2021, Invited, Lead author, Corresponding author
- 中枢神経シナプス前終末における小胞動態の超解像ライブイメージング緑川光春月刊「細胞 The CELL」12月号「マルチスケールな精神病態」, Dec. 2019, Invited, Lead author
- Coupling between Ca2+ channels and endocytosis at the calyx of HeldMitsuharu Midorikawa; Takeshi SakabaJOURNAL OF PHYSIOLOGICAL SCIENCES, 2013
- Syntaxin molecules reversibly assemble into clusters beneath secretory granulesMichelle Knowles; Sebastian Barg; Wolfhard Almers; Lei Wan; Xi Chen; Mitsuharu MidorikawaABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2011
- Imaging the Disassembly of Syntxin Cluster during the Exocytosis of Single Secretory GranulesMitsuharu Midorikawa; Wolfhard AlmersBIOPHYSICAL JOURNAL, Jan. 2010
- 網膜における一過性応答と持続性応答の発生機構立花政夫; 緑川光春; 塚本吉彦生化学, 2008
- Fusion sites of synaptic vesicles in goldfish retinal bipolar cellsMitsuharu Midorikawa; Masao TachibanaNEUROSCIENCE RESEARCH, 2006
- キンギョMb1型双極細胞におけるCa2+マイクロドメインと開口放出部位(Ca2+ microdomains and fusion sites of synaptic vesicles in goldfish retinal bipolar cells)緑川 光春; 浅香 知光; 立花 政夫神経化学, Aug. 2004
- 網膜双極細胞におけるシナプス小胞の配置に対するフォルボール・エステルの効果バーグランド健; 塚本吉彦; 緑川光春; 立花政夫日本神経科学大会プログラム・抄録集, 2001
- 網膜双極細胞におけるシナプス小胞の配置に対するフォルボール・エステルの効果バーグランド健; 塚本吉彦; 緑川光春; 立花政夫神経化学, 2001
Awards
list
Last Updated :2026/08/20
Education
Teaching subject(s)
- From 01 Apr. 2026, To 31 Mar. 2027Sports Science IIU102, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2026, To 31 Mar. 2027Sports Science IIU102, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2026, To 31 Mar. 2027Practice in Rehabilitation Education IM622, Fall, Graduate School of Medicine, 1
- From 01 Apr. 2026, To 31 Mar. 2027Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2026, To 31 Mar. 2027Introduction to Human Health Sciences IV3204, Fall, Faculty of Medicine, 1
- From 01 Apr. 2026, To 31 Mar. 2027Introduction to Human Health Sciences III3203, Fall, Faculty of Medicine, 1
- From 01 Apr. 2026, To 31 Mar. 2027Community based Clinical Practice7241, Spring, Faculty of Medicine, 1
- From 01 Apr. 2026, To 31 Mar. 2027Practice of Advanced Occupational Therapy7240, Year-long, Faculty of Medicine, 1
- From 01 Apr. 2026, To 31 Mar. 2027Practice in Physiology and Sleep MedicineM617, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Advanced Occupational Therapy : LectureM616, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Essential Physiology IE061, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Basic Medicine I (Neurophysiology )H163, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Basic Medicine I (Physiology I)H154, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Essential Physiology IIE062, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Neurophysiology3242, Fall, Faculty of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Neurophysiology I3213, Fall, Faculty of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Physiology II3211, Spring, Faculty of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Physiology I3210, Spring, Faculty of Medicine, 2
- From 01 Apr. 2026, To 31 Mar. 2027Preliminary Clinical Practice7236, Year-long, Faculty of Medicine, 3
- From 01 Apr. 2026, To 31 Mar. 2027Graduate Research7229, Year-long, Faculty of Medicine, 3
- From 01 Apr. 2026, To 31 Mar. 2027Comprehensive Clinical Practice II7242, Spring, Faculty of Medicine, 9
- From 01 Apr. 2026, To 31 Mar. 2027Comprehensive Clinical Practice I7237, Fall, Faculty of Medicine, 9
- From 01 Apr. 2026, To 31 Mar. 2027Research on Advanced RehabilitationM619, Year-long, Graduate School of Medicine, 8
- From 01 Apr. 2026, To 31 Mar. 2027Advanced Practice in Physiology and Sleep MedicineD617, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2026, To 31 Mar. 2027Advanced Physiology and Sleep MedicineD616, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2026, To 31 Mar. 2027Physiology and Sleep Medicine SeminarM618, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2026, To 31 Mar. 2027The Graduate Courses of Integrated Reseach Training (seminar)M052, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2026, To 31 Mar. 2027Advanced Research in Physiology and Sleep MedicineD618, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2025, To 31 Mar. 2026Sports Science IIU102, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Sports Science IIU102, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Practice in Rehabilitation Education IM622, Fall, Graduate School of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Introduction to Human Health Sciences IV3204, Fall, Faculty of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Introduction to Human Health Sciences III3203, Fall, Faculty of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Community based Clinical Practice7241, Spring, Faculty of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Practice of Advanced Occupational Therapy7240, Year-long, Faculty of Medicine, 1
- From 01 Apr. 2025, To 31 Mar. 2026Basic Medicine I (Physiology I)H154, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Essential Physiology IIE062, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Essential Physiology IE061, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Practice in Physiology and Sleep MedicineM617, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Advanced Occupational Therapy : LectureM616, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Basic Medicine I (Neurophysiology )H163, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Neurophysiology3242, Fall, Faculty of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Neurophysiology I3213, Fall, Faculty of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Physiology II3211, Spring, Faculty of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Physiology I3210, Spring, Faculty of Medicine, 2
- From 01 Apr. 2025, To 31 Mar. 2026Preliminary Clinical Practice7236, Year-long, Faculty of Medicine, 3
- From 01 Apr. 2025, To 31 Mar. 2026Graduate Research7229, Year-long, Faculty of Medicine, 3
- From 01 Apr. 2025, To 31 Mar. 2026Comprehensive Clinical Practice II7242, Spring, Faculty of Medicine, 9
- From 01 Apr. 2025, To 31 Mar. 2026Comprehensive Clinical Practice I7237, Fall, Faculty of Medicine, 9
- From 01 Apr. 2025, To 31 Mar. 2026Research on Advanced RehabilitationM619, Year-long, Graduate School of Medicine, 8
- From 01 Apr. 2025, To 31 Mar. 2026The Graduate Courses of Integrated Reseach Training (seminar)M052, Year-long, Graduate School of Medicine, 4
- From 01 Apr. 2024, To 31 Mar. 2025Sports Science IIU102, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Sports Science IIU102, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Practice in Rehabilitation Education IM622, Fall, Graduate School of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Community based Clinical Practice7241, Spring, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Introduction to Human Health Sciences III3203, Fall, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Practice of Advanced Occupational Therapy7240, Year-long, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Introduction to Human Health Sciences IV3204, Fall, Faculty of Medicine, 1
- From 01 Apr. 2024, To 31 Mar. 2025Basic Medicine I (Neurophysiology )H163, Fall, Graduate School of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Basic Medicine I (Physiology I)H154, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Essential Physiology IIE062, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Occupational Therapy : LectureM616, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Essential Physiology IE061, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Neurophysiology I3213, Fall, Faculty of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Physiology II3211, Spring, Faculty of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Physiology I3210, Spring, Faculty of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Neurophysiology3242, Fall, Faculty of Medicine, 2
- From 01 Apr. 2024, To 31 Mar. 2025Preliminary Clinical Practice7236, Year-long, Faculty of Medicine, 3
- From 01 Apr. 2024, To 31 Mar. 2025Graduate Research7229, Year-long, Faculty of Medicine, 3
- From 01 Apr. 2024, To 31 Mar. 2025Comprehensive Clinical Practice II7242, Spring, Faculty of Medicine, 9
- From 01 Apr. 2024, To 31 Mar. 2025Comprehensive Clinical Practice I7237, Fall, Faculty of Medicine, 9
- From 01 Apr. 2024, To 31 Mar. 2025Research on Advanced RehabilitationM619, Year-long, Graduate School of Medicine, 8
- From 01 Apr. 2023, To 31 Mar. 2024Sports Science IIU102, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Sports Science IIU102, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Physiology Practice3241, Fall, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Essential Physiology IE061, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Essential Physiology IIE062, Spring, Graduate School of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Neurophysiology3242, Fall, Faculty of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Neurophysiology I3213, Fall, Faculty of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Physiology II3211, Spring, Faculty of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Physiology I3210, Spring, Faculty of Medicine, 2
- From 01 Apr. 2023, To 31 Mar. 2024Graduate Research7229, Year-long, Faculty of Medicine, 3
- From 01 Apr. 2023, To 31 Mar. 2024Research on Advanced RehabilitationM619, Year-long, Graduate School of Medicine, 8
Participation in PhD Defense
- Standing postural control during an upper limb reaching task in a mixed reality condition: analysis of center of pressure and lower limb muscle activitiesZHANG YUNHE, Graduate School of Medicine, Chief Examiner23 Jan. 2026
- Attenuating Cartilage Degeneration in a Low Mechanical Compression Rat Model Through Intra-Articular Injections of Allogeneic Bone Marrow-Derived Mesenchymal Stem CellsCHIA TAI, Graduate School of Medicine, Sub-chief Examiner25 Nov. 2025
- Cell transplantation-mediated dystrophin supplementation efficacy in Duchenne muscular dystrophy mouse motor function improvement demonstrated by enhanced skeletal muscle fatigue toleranceCLEMENCE KIHO YOSHIOKA, Graduate School of Medicine, Chief Examiner24 Mar. 2025
- Attentional focus differentially modulates the corticospinal and intracortical excitability during dynamic and static exerciseMATSUMOTO AMIRI, Graduate School of Medicine, Chief Examiner23 Jul. 2024
- Epithelial development of the urinary collecting system in the human embryoSAIZONOU OMOLOTO MARIE ANGE JOELLE, Graduate School of Medicine, Sub-chief Examiner25 Nov. 2024
