Basic Information

Faculty

• Faculty of Engineering

Email Address

• Email Address

  hashizume.osamu.7mkyoto-u.ac.jp

Academic Degree

• 25 Mar. 2010

  筑波大学修士（理学）
• 30 Nov. 2012

  筑波大学博士（理学）

Academic Resume (Undergraduate School/Majors)

• 筑波大学, 第二学群生物学類, 卒業

Research History

• From Dec. 2022, To Present

  Kyoto University, Graduate School of Engineering, 助教
• From Apr. 2022, To Nov. 2022

  Osaka University, Research Institute for Microbial Diseases, 助教
• From Apr. 2015, To Mar. 2022

  Osaka University, Research Institute for Microbial Diseases, 特任研究員
• From Aug. 2014, To Mar. 2015

  University of Tsukuba, Faculty of Life and Environmental Sciences, 研究員
• From Apr. 2014, To Sep. 2014

  University of Tsukuba, 生命環境科学研究科, 研究生
• From Dec. 2012, To Mar. 2014

  University of Tsukuba, Faculty of Life and Environmental Sciences, 博士研究員

ID,URL

• J-Global ID

  201801015013989813

researchmap URL

• https://researchmap.jp/O_Hashi

Research

Research Areas

• Life sciences, Molecular biology

Papers

• Intestinal Mg2+ accumulation induced by cnnm mutations decreases the body size by suppressing TORC2 signaling in Caenorhabditis elegans.

  Osamu Hashizume; Tomofumi Kawabe; Yosuke Funato; Hiroaki Miki

  Developmental biology, May 2024, Peer-reviewed

  
• Phosphatase-independent role of phosphatase of regenerating liver in cancer progression.

  Yosuke Funato; Osamu Hashizume; Hiroaki Miki

  Cancer science, 26 Oct. 2022, Peer-reviewed

  
• Role of adenomatous polyposis coli in proliferation and differentiation of colon epithelial cells in organoid culture.

  Daisuke Yamazaki; Osamu Hashizume; Shiho Taniguchi; Yosuke Funato; Hiroaki Miki

  Scientific reports, 17 Feb. 2021, Peer-reviewed

  
• The Oncogenic PRL Protein Causes Acid Addiction of Cells by Stimulating Lysosomal Exocytosis.

  Yosuke Funato; Atsushi Yoshida; Yusuke Hirata; Osamu Hashizume; Daisuke Yamazaki; Hiroaki Miki

  Developmental cell, 23 Nov. 2020, Peer-reviewed

  
• Excessive Mg2+ Impairs Intestinal Homeostasis by Enhanced Production of Adenosine Triphosphate and Reactive Oxygen Species.

  Osamu Hashizume; Yosuke Funato; Daisuke Yamazaki; Hiroaki Miki

  Antioxidants & redox signaling, 01 Jul. 2020, Peer-reviewed

  
• Mice deficient in the Shmt2 gene have mitochondrial respiration defects and are embryonic lethal

  Haruna Tani; Sakiko Ohnishi; Hiroshi Shitara; Takayuki Mito; Midori Yamaguchi; Hiromichi Yonekawa; Osamu Hashizume; Kaori Ishikawa; Kazuto Nakada; Jun Ichi Hayashi

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

  
• Mg2+ Extrusion from Intestinal Epithelia by CNNM Proteins Is Essential for Gonadogenesis via AMPK-TORC1 Signaling in Caenorhabditis elegans.

  Tasuku Ishii; Yosuke Funato; Osamu Hashizume; Daisuke Yamazaki; Yusuke Hirata; Kiyoji Nishiwaki; Nozomu Kono; Hiroyuki Arai; Hiroaki Miki

  PLoS genetics, Aug. 2016, Peer-reviewed

  
• Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging

  Jun Ichi Hayashi; Osamu Hashizume; Kaori Ishikawa; Akinori Shimizu

  Current Opinion in Genetics and Development, 01 Jun. 2016, Peer-reviewed

  
• Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage

  Takehiro Suzuki; Hiroaki Yamaguchi; Motoi Kikusato; Osamu Hashizume; Satoru Nagatoishi; Akihiro Matsuo; Takeya Sato; Tai Kudo; Tetsuro Matsuhashi; Kazutaka Murayama; Yuki Ohba; Shun Watanabe; Shin Ichiro Kanno; Daichi Minaki; Daisuke Saigusa; Hiroko Shinbo; Nobuyoshi Mori; Akinori Yuri; Miyuki Yokoro; Eikan Mishima; Hisato Shima; Yasutoshi Akiyama; Yoichi Takeuchi; Koichi Kikuchi; Takafumi Toyohara; Chitose Suzuki; Takaharu Ichimura; Jun Ichi Anzai; Masahiro Kohzuki; Nariyasu Mano; Shigeo Kure; Teruyuki Yanagisawa; Yoshihisa Tomioka; Masaaki Toyomizu; Kohei Tsumoto; Kazuto Nakada; Joseph V. Bonventre; Sadayoshi Ito; Hitoshi Osaka; Ken Ichi Hayashi; Takaaki Abe

  Journal of the American Society of Nephrology, 2016, Peer-reviewed

  
• Erratum: Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects (Scientific Reports (2015) 5 (10434)) DOI: 10.1038/srep10434)

  Osamu Hashizume; Sakiko Ohnishi; Takayuki Mito; Akinori Shimizu; Kaori Ishikawa; Kazuto Nakada; Manabu Soda; Hiroyuki Mano; Sumie Togayachi; Hiroyuki Miyoshi; Keisuke Okita; Jun Ichi Hayashi

  Scientific Reports, 05 Oct. 2015, Peer-reviewed

  
• G7731A mutation in mouse mitochondrial tRNA^Lys regulates late-onset disorders in transmitochondrial mice

  Akinori Shimizu; Takayuki Mito; Osamu Hashizume; Hiromichi Yonekawa; Kaori Ishikawa; Kazuto Nakada; Jun Ichi Hayashi

  Biochemical and Biophysical Research Communications, 30 May 2015, Peer-reviewed

  
• A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA

  Osamu Hashizume; Haruka Yamanashi; Makoto M. Taketo; Kazuto Nakada; Jun Ichi Hayashi

  PLoS ONE, 04 Mar. 2015, Peer-reviewed

  
• Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects

  Shunkei Enoki; Akinori Shimizu; Chisato Hayashi; Hirotake Imanishi; Osamu Hashizume; Kazuyuki Mekada; Hitoshi Suzuki; Tetsuo Hashimoto; Kazuto Nakada; Jun Ichi Hayashi

  Experimental Animals, 2014, Peer-reviewed

  
• Administration of an antioxidant prevents lymphoma development in transmitochondrial mice overproducing reactive oxygen species

  Haruka Yamanashi; Osamu Hashizume; Hiromichi Yonekawa; Kazuto Nakada; Jun Ichi Hayashi

  Experimental Animals, 2014, Peer-reviewed

  
• Mitochondrial DNA Mutations in Mutator Mice Confer Respiration Defects and B-Cell Lymphoma Development

  Takayuki Mito; Yoshiaki Kikkawa; Akinori Shimizu; Osamu Hashizume; Shun Katada; Hirotake Imanishi; Azusa Ota; Yukina Kato; Kazuto Nakada; Jun Ichi Hayashi

  PLoS ONE, 13 Feb. 2013, Peer-reviewed

  
• Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development

  Osamu Hashizume; Akinori Shimizu; Mutsumi Yokota; Atsuko Sugiyama; Kazuto Nakada; Hiroyuki Miyoshi; Makiko Itami; Miki Ohira; Hiroki Nagase; Keizo Takenaga; Jun Ichi Hayashi

  Proceedings of the National Academy of Sciences of the United States of America, 26 Jun. 2012, Peer-reviewed

  
• Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells

  Mutsumi Yokota; Hiroshi Shitara; Osamu Hashizume; Kaori Ishikawa; Kazuto Nakada; Rie Ishii; Choji Taya; Keizo Takenaga; Hiromichi Yonekawa; Jun Ichi Hayashi

  FEBS Letters, Sep. 2010, Peer-reviewed

  
• Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis

  Kaori Ishikawa; Osamu Hashizume; Nobuko Koshikawa; Sayaka Fukuda; Kazuto Nakada; Keizo Takenaga; Jun Ichi Hayashi

  FEBS Letters, 15 Oct. 2008, Peer-reviewed

  

Misc.

• 核コードのGCAT遺伝子とSHMT2遺伝子のエピジェネティック制御がヒトの加齢にともなうミトコンドリア呼吸欠損を誘発する.

  清水章文; 橋爪脩; 三藤崇行; 林純一

  細胞工学, Nov. 2015

  

Presentations

• cnnm変異により線虫のボディサイズが縮小する仕組みの解析

  橋爪 脩、川邊 智史、船戸 洋佑、三木 裕明

  第44回日本分子生物学会年会, Dec. 2021

  
• 細胞内でのマグネシウム蓄積が引き起こす過剰な ROS と ATP 産生

  橋爪脩

  ミトコンドリアサイエンスワークショプ, 14 May 2019

  
• 過剰なマグネシウムが引き起こすミトコンドリアでの活性酸素種とATPの過剰産生

  橋爪脩; 船戸洋佑; 三木裕明

  第18回 日本ミトコンドリア学会年会, Dec. 2018

  
• 過剰なマグネシウムが引き起こすミトコンドリアでのATPとROSの過剰産生

  橋爪脩; 船戸洋佑; 三木裕明

  第91回 日本生化学会大会, Sep. 2018

  
• Overproduction of ATP and reactive oxygen species in mitochondria by excessive magnesium

  橋爪脩

  微生物病研究所 平成２９年度研究業績発表会, 2018

  
• 細胞内Mg2+の過剰蓄積が活性酸素種（ROS）レベル上昇と線虫の寿命短縮を引き起こす

  橋爪脩; 船戸洋佑; 三木裕明

  新学術領域 酸素生物学・ダイイングコード合同若手会議, 2018

  
• Mg2+トランスポーターCNNMは線虫でROSレベルと寿命を調節する

  橋爪脩; 船戸洋佑; 三木裕明

  生命科学系学会合同年次大会, 2017

  
• ROSを過剰産生する変異型mtDNA導入マウスへの抗酸化剤投与による病態抑制効果の検証

  橋爪脩; 山梨晴香; 中田和人; 林純一

  日本ミトコンドリア学会 第14回年会, 2014

  
• 核-ミトコンドリアゲノム間の機能的不和合性を導入したモデル生物の作出

  橋爪脩; 中田和人; 林純一

  第二回マトリョーシカ型生物学研究会, 2013

  
• ROS産生を伴う変異型mtDNAを導入したマウスの病態解析

  橋爪脩; 中田和人; 林純一

  日本ミトコンドリア学会 第12回年会, 2012

  
• ROSを過産生させる変異型mtDNAを導入したマウスの病態解析

  橋爪脩; 中田和人; 林純一

  第一回マトリョーシカ型生物学研究会・全体班会議, 2012

  
• mtDNA突然変異による解糖系亢進ががん転移能に与える影響の解析

  橋爪脩; 中田和人; 林純一

  日本ミトコンドリア学会 第9回年会, 2009

  

Awards

• 19 Jan. 2018

  研究業績発表会優秀学術賞（微生物病研究所）

External funds: Kakenhi

• ミトコンドリアからリソソームへの特異的な活性酸素シグナル伝達機構

  Grant-in-Aid for Scientific Research (C)

  Basic Section 44010:Cell biology-related

  Kyoto University

  橋爪 脩

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  マグネシウム;活性酸素種;ミトコンドリア;リソソーム;TRPML;酸性環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06205/
• Mitochondrial energy metabolism abnormalities and cancer malignancy induced by excess Mg ions.

  Grant-in-Aid for Early-Career Scientists

  Basic Section 44010:Cell biology-related

  Kyoto University;Osaka University

  Osamu Hashizume

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  Mg2+;CNNM;PRL;ATP;ミトコンドリア;がん悪性化;マグネシウム;活性酸素種;エネルギー代謝;ROS;腸上皮細胞;酸化ストレス;NADH;酸素消費;トランスポーター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16125/
• The mechanism of blood pressure regulation associated with magnesium reabsorption

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  Osamu Hashizume

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  マグネシウム;腎臓;血圧;レニン;CNNM2;TRPM6;再吸収;腎臓遠位尿細管;血圧調節;マグネシウム再吸収;レドックス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K19034/
• マグネシウム再吸収を介した新たな血圧調節機構の解明

  Grant-in-Aid for Research Activity Start-up

  Osaka University

  橋爪 脩

  From 28 Aug. 2015, To 31 Mar. 2016, Project Closed

  血圧調節;マグネシウム;トランポーター;酸化ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H06367/