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Yamamoto, Takuya

Center for iPS Cell Research and Application (CiRA) Professor

Yamamoto, Takuya
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    Last Updated :2025/06/20

    Basic Information

    Concurrent Affiliation

    • Institute for Advanced Study, ヒト生物学高等研究拠点, コア長、主任研究者

    Academic Degree

    • 修士（生命科学）(京都大学)
    • 博士（生命科学）(京都大学)

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2025/06/20

      Research

      Research Topics, Overview of the research

      • Research Topics

        Elucidation of molecular basis of somatic cell reprogramming process

      • Overview of the research

        Elucidation of the molecular mechanisms of iPS cell induction processes is an important step toward applications of iPS cells for regenerative medicine. Analytical techniques (dry), such as bioinformatics, as well as molecular- and cell-biological experimental techniques (wet) are essential to extract biologically meaningful information from the enormous amounts of data acquired by such analytical devices as microarrays and the next-generation sequencers.

      Research Areas

      • Life sciences, Molecular biology

      Papers

      • Zinc eluted from glassware is a risk factor for embryo development in human and animal assisted reproduction
        Tatsuma Yao; Hisato Kobayashi; Tatsuki Hirai; Yuta Tokuoka; Mikiko Tokoro; Yuta Asayama; Yuka Suzuki; Yu Hatano; Hiroki Ikeda; Satoshi Sugimura; Takuya Yamamoto; Takahiro G Yamada; Yoshihiko Hosoi; Akira Funahashi; Noritaka Fukunaga; Yoshimasa Asada; Kazuki Kurimoto; Kazuo Yamagata
        Biology of Reproduction, 02 Apr. 2025
      • H1FOO-DD promotes efficiency and uniformity in reprogramming to naive pluripotency.
        Akira Kunitomi; Ryoko Hirohata; Mitsujiro Osawa; Kaho Washizu; Vanessa Arreola; Norikazu Saiki; Tomoaki M Kato; Masaki Nomura; Haruko Kunitomi; Tokiko Ohkame; Yusuke Ohkame; Jitsutaro Kawaguchi; Hiroto Hara; Kohji Kusano; Takuya Yamamoto; Yasuhiro Takashima; Shugo Tohyama; Shinsuke Yuasa; Keiichi Fukuda; Naoko Takasu; Shinya Yamanaka
        Stem cell reports, 23 Apr. 2024
      • The reciprocal regulation between mitochondrial-associated membranes and Notch signaling in skeletal muscle atrophy.
        Yurika Ito; Mari Yamagata; Takuya Yamamoto; Katsuya Hirasaka; Takeshi Nikawa; Takahiko Sato
        eLife, 15 Dec. 2023
      • ヒトiPS細胞を用いた下垂体疾患研究
        松本 隆作; 蟹江 慶太郎; 坂東 弘教; 山本 拓也; 高橋 裕
        糖尿病・内分泌代謝科, Sep. 2022
      • 神経筋疾患克服へ向けた先端ゲノム創薬 iPS細胞技術を活用した筋疾患に対する治療法開発研究
        櫻井 英俊; 趙 明明; Nalbandian Harutiun Minas; 竹中 菜々[蜷川]; 原田 文; 池谷 真; 堀田 秋津; 山本 拓也; 上住 聡芳; 野口 悟
        日本筋学会学術集会プログラム・抄録集, Aug. 2022
      • Non-viral generation of transgenic non-human primates via the piggyBac transposon system.
        Masataka Nakaya; Chizuru Iwatani; Setsuko Tsukiyama-Fujii; Ai Mieda; Shoko Tarumoto; Taro Tsujimura; Takuya Yamamoto; Takafumi Ichikawa; Tomonori Nakamura; Ichiro Terakado; Ikuo Kawamoto; Takahiro Nakagawa; Iori Itagaki; Mitinori Saitou; Hideaki Tsuchiya; Tomoyuki Tsukiyama
        Nature communications, 24 Mar. 2025
      • The balance between IFN-γ and ERK/MAPK signaling activities ensures lifelong maintenance of intestinal stem cells
        May Nakajima-Koyama; Mio Kabata; Joonseong Lee; Yuko Sogabe; Satoko Sakurai; Akira Hirota; Mizuki Kimura; Tomonori Nakamura; Yusuke Imoto; Kohei Kometani; Yoko Hamazaki; Yasuaki Hiraoka; Mitinori Saitou; Eisuke Nishida; Takuya Yamamoto
        Cell Reports, Feb. 2025
      • A versatile in vivo platform for reversible control of transgene expression in adult tissues.
        Jumpei Taguchi; Yosuke Yamada; Sho Ohta; Fumie Nakasuka; Takuya Yamamoto; Manabu Ozawa; Yasuhiro Yamada
        Stem cell reports, 20 Nov. 2024
      • Zonated Wnt/β-catenin signal-activated cardiomyocytes at the atrioventricular canal promote coronary vessel formation in zebrafish.
        Ayano Chiba; Takuya Yamamoto; Hajime Fukui; Moe Fukumoto; Manabu Shirai; Hiroyuki Nakajima; Naoki Mochizuki
        Developmental cell, 08 Oct. 2024
      • Heparan Sulfate Chain-Conjugated Laminin-E8 Fragments Advance Paraxial Mesodermal Differentiation Followed by High Myogenic Induction from hiPSCs.
        Mingming Zhao; Yukimasa Taniguchi; Chisei Shimono; Tatsuya Jonouchi; Yushen Cheng; Yasuhiro Shimizu; Minas Nalbandian; Takuya Yamamoto; Masato Nakagawa; Kiyotoshi Sekiguchi; Hidetoshi Sakurai
        Advanced science (Weinheim, Baden-Wurttemberg, Germany), 29 Apr. 2024
      • Construction of multilayered small intestine-like tissue by reproducing interstitial flow
        Sayaka Deguchi; Kaori Kosugi; Naoki Takeishi; Yukio Watanabe; Shiho Morimoto; Ryosuke Negoro; Fuki Yokoi; Hiroki Futatsusako; May Nakajima-Koyama; Mio Iwasaki; Takuya Yamamoto; Yoshiya Kawaguchi; Yu-suke Torisawa; Kazuo Takayama
        Cell Stem Cell, Jul. 2024
      • In vitro reconstitution of epigenetic reprogramming in the human germ line.
        Yusuke Murase; Ryuta Yokogawa; Yukihiro Yabuta; Masahiro Nagano; Yoshitaka Katou; Manami Mizuyama; Ayaka Kitamura; Pimpitcha Puangsricharoen; Chika Yamashiro; Bo Hu; Ken Mizuta; Taro Tsujimura; Takuya Yamamoto; Kosuke Ogata; Yasushi Ishihama; Mitinori Saitou
        Nature, 20 May 2024
      • Hit-and-run silencing of endogenous DUX4 by targeting DNA hypomethylation on D4Z4 repeats in facioscapulohumeral muscular dystrophy
        Mitsuru Sasaki-Honda; Tatsuya Jonouchi; Meni Arai; Junjie He; Kazusa Okita; Satoko Sakurai; Takuya Yamamoto; Hidetoshi Sakurai
        12 Apr. 2022
      • Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases.
        Masato Tanaka; Keisuke Shirakura; Yui Takayama; Miki Μatsui; Yukio Watanabe; Takuya Yamamoto; Junya Takahashi; Shota Tanaka; Nobumasa Hino; Takefumi Doi; Masanori Obana; Yasushi Fujio; Kazuo Takayama; Yoshiaki Okada
        Communications biology, 18 May 2024
      • Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants.
        Atsushi Masui; Rina Hashimoto; Yasufumi Matsumura; Takuya Yamamoto; Miki Nagao; Takeshi Noda; Kazuo Takayama; Shimpei Gotoh
        Stem cell reports, 09 Apr. 2024
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      • A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility
        Si Jing Chen; Kazuya Hashimoto; Kosuke Fujio; Karin Hayashi; Sudip Kumar Paul; Akinori Yuzuriha; Wei-Yin Qiu; Emiri Nakamura; Maria Alejandra Kanashiro; Mio Kabata; Sou Nakamura; Naoshi Sugimoto; Atsushi Kaneda; Takuya Yamamoto; Hirohide Saito; Naoya Takayama; Koji Eto
        Nature Communications, 22 Mar. 2024
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      • Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva.
        Liping Sun; Yonghui Jin; Megumi Nishio; Makoto Watanabe; Takeshi Kamakura; Sanae Nagata; Masayuki Fukuda; Hirotsugu Maekawa; Shunsuke Kawai; Takuya Yamamoto; Junya Toguchida
        Life science alliance, May 2024
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      • SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids.
        Kazuya Fujimoto; Yoshikazu Kameda; Yuta Nagano; Sayaka Deguchi; Takuya Yamamoto; Rafal P Krol; Peter Gee; Yasufumi Matsumura; Toru Okamoto; Miki Nagao; Kazuo Takayama; Ryuji Yokokawa
        Lab on a chip, 22 Jan. 2024
      • Selective induction of human renal interstitial progenitor-like cell lineages from iPSCs reveals development of mesangial and EPO-producing cells
        Hiraku Tsujimoto; Azusa Hoshina; Shin-Ichi Mae; Toshikazu Araoka; Wang Changting; Yoshihiro Ijiri; May Nakajima-Koyama; Satoko Sakurai; Kazusa Okita; Ken Mizuta; Akira Niwa; Megumu K. Saito; Mitinori Saitou; Takuya Yamamoto; Cecilia Graneli; Kevin J. Woollard; Kenji Osafune
        Cell Reports, Jan. 2024
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      • Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice
        Satoshi Kozuki; Mio Kabata; Satoko Sakurai; Keiko Iwaisako; Tomomi Nishimura; Masakazu Toi; Takuya Yamamoto; Fumiko Toyoshima
        Communications Biology, 04 Dec. 2023
      • Hypoblast from human pluripotent stem cells regulates epiblast development.
        Takumi Okubo; Nicolas Rivron; Mio Kabata; Hideki Masaki; Keiko Kishimoto; Katsunori Semi; May Nakajima-Koyama; Haruko Kunitomi; Belinda Kaswandy; Hideyuki Sato; Hiromitsu Nakauchi; Knut Woltjen; Mitinori Saitou; Erika Sasaki; Takuya Yamamoto; Yasuhiro Takashima
        Nature, 05 Dec. 2023
      • Intracytoplasmic sperm injection induces transgenerational abnormalities in mice
        Mito Kanatsu-Shinohara; Yusuke Shiromoto; Narumi Ogonuki; Kimiko Inoue; Satoko Hattori; Kento Miura; Naomi Watanabe; Ayumi Hasegawa; Keiji Mochida; Takuya Yamamoto; Tsuyoshi Miyakawa; Atsuo Ogura; Takashi Shinohara
        Journal of Clinical Investigation, 15 Nov. 2023
      • High-quality single-cell transcriptomics from ovarian histological sections during folliculogenesis.
        Hiroki Ikeda; Shintaro Miyao; So Nagaoka; Tomoya Takashima; Sze-Ming Law; Takuya Yamamoto; Kazuki Kurimoto
        Life science alliance, Nov. 2023
      • Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys
        Takahisa Yoshikawa; Akiko Oguchi; Naoya Toriu; Yuki Sato; Takashi Kobayashi; Osamu Ogawa; Hironori Haga; Satoko Sakurai; Takuya Yamamoto; Yasuhiro Murakawa; Motoko Yanagita
        Journal of the American Society of Nephrology, 07 Aug. 2023
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      • Rat post-implantation epiblast-derived pluripotent stem cells produce functional germ cells
        Kenyu Iwatsuki; Mami Oikawa; Hisato Kobayashi; Christopher A. Penfold; Makoto Sanbo; Takuya Yamamoto; Shinichi Hochi; Kazuki Kurimoto; Masumi Hirabayashi; Toshihiro Kobayashi
        Cell Reports Methods, Jul. 2023
      • Cellular senescence induction leads to progressive cell death via the INK4a-RB pathway in naked mole-rats.
        Yoshimi Kawamura; Kaori Oka; Takashi Semba; Mayuko Takamori; Yuki Sugiura; Riyo Yamasaki; Yusuke Suzuki; Takeshi Chujo; Mari Nagase; Yuki Oiwa; Shusuke Fujioka; Sayuri Homma; Yuki Yamamura; Shingo Miyawaki; Minoru Narita; Takaichi Fukuda; Yusuke Sakai; Takatsugu Ishimoto; Kazuhito Tomizawa; Makoto Suematsu; Takuya Yamamoto; Hidemasa Bono; Hideyuki Okano; Kyoko Miura
        The EMBO journal, 11 Jul. 2023, Peer-reviewed
      • Directionality of developing skeletal muscles is set by mechanical forces.
        Kazunori Sunadome; Alek G Erickson; Delf Kah; Ben Fabry; Csaba Adori; Polina Kameneva; Louis Faure; Shigeaki Kanatani; Marketa Kaucka; Ivar Dehnisch Ellström; Marketa Tesarova; Tomas Zikmund; Jozef Kaiser; Steven Edwards; Koichiro Maki; Taiji Adachi; Takuya Yamamoto; Kaj Fried; Igor Adameyko
        Nature communications, 27 May 2023, Peer-reviewed
      • Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids.
        Yukio Watanabe; Izumi Kimura; Rina Hashimoto; Ayaka Sakamoto; Naoko Yasuhara; Takuya Yamamoto; Kei Sato; Kazuo Takayama
        Journal of medical virology, Jun. 2023
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      • CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.
        Yuki Sato; Akiko Oguchi; Yuji Fukushima; Kyoko Masuda; Naoya Toriu; Keisuke Taniguchi; Takahisa Yoshikawa; Xiaotong Cui; Makiko Kondo; Takeshi Hosoi; Shota Komidori; Yoko Shimizu; Harumi Fujita; Li Jiang; Yingyi Kong; Takashi Yamanashi; Jun Seita; Takuya Yamamoto; Shinya Toyokuni; Yoko Hamazaki; Masakazu Hattori; Yasunobu Yoshikai; Peter Boor; Jürgen Floege; Hiroshi Kawamoto; Yasuhiro Murakawa; Nagahiro Minato; Motoko Yanagita
        The Journal of clinical investigation, 18 Jan. 2022
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      • Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells.
        Emi Sano; Sayaka Deguchi; Ayaka Sakamoto; Natsumi Mimura; Ai Hirabayashi; Yukiko Muramoto; Takeshi Noda; Takuya Yamamoto; Kazuo Takayama
        iScience, 21 May 2021, Peer-reviewed
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      • Allogeneic offspring produced by induction of PD-L1 in spermatogonial stem cells via self-renewal stimulation.
        Takashi Shinohara; Takuya Yamamoto; Hiroko Morimoto; Yusuke Shiromoto; Mito Kanatsu-Shinohara
        Stem cell reports, 11 Apr. 2023, Peer-reviewed
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      • Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids.
        Rina Hashimoto; Tomokazu Tamura; Yukio Watanabe; Ayaka Sakamoto; Naoko Yasuhara; Hayato Ito; Masahiro Nakano; Hiromitsu Fuse; Akira Ohta; Takeshi Noda; Yasufumi Matsumura; Miki Nagao; Takuya Yamamoto; Takasuke Fukuhara; Kazuo Takayama
        Molecular pharmaceutics, 03 Apr. 2023, Peer-reviewed
      • Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips.
        Sayaka Deguchi; Kaori Kosugi; Rina Hashimoto; Ayaka Sakamoto; Masaki Yamamoto; Rafal P Krol; Peter Gee; Ryosuke Negoro; Takeshi Noda; Takuya Yamamoto; Yu-Suke Torisawa; Miki Nagao; Kazuo Takayama
        PNAS nexus, Mar. 2023, Peer-reviewed
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      • Endoderm-derived islet1-expressing cells differentiate into endothelial cells to function as the vascular HSPC niche in zebrafish.
        Hiroyuki Nakajima; Hiroyuki Ishikawa; Takuya Yamamoto; Ayano Chiba; Hajime Fukui; Keisuke Sako; Moe Fukumoto; Kenny Mattonet; Hyouk-Bum Kwon; Subhra P Hui; Gergana D Dobreva; Kazu Kikuchi; Christian S M Helker; Didier Y R Stainier; Naoki Mochizuki
        Developmental cell, 06 Feb. 2023, Peer-reviewed
      • Reconstituting human somitogenesis in vitro.
        Yoshihiro Yamanaka; Sofiane Hamidi; Kumiko Yoshioka-Kobayashi; Sirajam Munira; Kazunori Sunadome; Yi Zhang; Yuzuru Kurokawa; Rolf Ericsson; Ai Mieda; Jamie L Thompson; Janet Kerwin; Steven Lisgo; Takuya Yamamoto; Naomi Moris; Alfonso Martinez-Arias; Taro Tsujimura; Cantas Alev
        Nature, Feb. 2023, Peer-reviewed
      • Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): A multicentre, open-label, dose-escalation phase 1 trial.
        Keiko Imamura; Yuishin Izumi; Makiko Nagai; Kazutoshi Nishiyama; Yasuhiro Watanabe; Ritsuko Hanajima; Naohiro Egawa; Takashi Ayaki; Ryosuke Oki; Koji Fujita; Ryuji Uozumi; Akiko Morinaga; Tomoko Hirohashi; Yosuke Fujii; Takuya Yamamoto; Harutsugu Tatebe; Takahiko Tokuda; Naoto Takahashi; Satoshi Morita; Ryosuke Takahashi; Haruhisa Inoue
        EClinicalMedicine, Nov. 2022
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      • Resistance to chemical carcinogenesis induction via a dampened inflammatory response in naked mole-rats.
        Kaori Oka; Shusuke Fujioka; Yoshimi Kawamura; Yoshihiro Komohara; Takeshi Chujo; Koki Sekiguchi; Yuki Yamamura; Yuki Oiwa; Natsuko Omamiuda-Ishikawa; Shohei Komaki; Yoichi Sutoh; Satoko Sakurai; Kazuhito Tomizawa; Hidemasa Bono; Atsushi Shimizu; Kimi Araki; Takuya Yamamoto; Yasuhiro Yamada; Hiroyuki Oshiumi; Kyoko Miura
        Communications biology, 30 Mar. 2022, Peer-reviewed
      • Generation of human bronchial organoids for SARS-CoV-2 research
        Tatsuya Suzuki; Yumi Itoh; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Toru Okamoto; Kazuo Takayama
        26 May 2020
      • Induction of fetal meiotic oocytes from embryonic stem cells in cynomolgus monkeys
        Sayuri Gyobu‐Motani; Yukihiro Yabuta; Ken Mizuta; Yoshitaka Katou; Ikuhiro Okamoto; Masanori Kawasaki; Ayaka Kitamura; Tomoyuki Tsukiyama; Chizuru Iwatani; Hideaki Tsuchiya; Taro Tsujimura; Takuya Yamamoto; Tomonori Nakamura; Mitinori Saitou
        The EMBO Journal, 16 Mar. 2023, Peer-reviewed
      • SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.
        Rina Hashimoto; Junya Takahashi; Keisuke Shirakura; Risa Funatsu; Kaori Kosugi; Sayaka Deguchi; Masaki Yamamoto; Yugo Tsunoda; Maaya Morita; Kosuke Muraoka; Masato Tanaka; Tomoaki Kanbara; Shota Tanaka; Shigeyuki Tamiya; Nagisa Tokunoh; Atsushi Kawai; Masahito Ikawa; Chikako Ono; Keisuke Tachibana; Masuo Kondoh; Masanori Obana; Yoshiharu Matsuura; Akihiro Ohsumi; Takeshi Noda; Takuya Yamamoto; Yasuo Yoshioka; Yu-Suke Torisawa; Hiroshi Date; Yasushi Fujio; Miki Nagao; Kazuo Takayama; Yoshiaki Okada
        Science advances, 23 Sep. 2022, Peer-reviewed
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      • RNA-Sequencing Analysis of Differentially Expressed Genes in Human iPSC-Derived Cardiomyocytes.
        Chikako Okubo; Megumi Narita; Takuya Yamamoto; Yoshinori Yoshida
        Methods in molecular biology (Clifton, N.J.), 2021
      • Cell response analysis in SARS-CoV-2 infected bronchial organoids.
        Emi Sano; Tatsuya Suzuki; Rina Hashimoto; Yumi Itoh; Ayaka Sakamoto; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Yukiko Muramoto; Takeshi Noda; Tomohiko Takasaki; Jun-Ichi Sakuragi; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Yasufumi Matsumura; Miki Nagao; Toru Okamoto; Kazuo Takayama
        Communications biology, 30 May 2022, Peer-reviewed
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      • Tceal5 and Tceal7 Function in C2C12 Myogenic Differentiation via Exosomes in Fetal Bovine Serum.
        Aika Sawada; Takuya Yamamoto; Takahiko Sato
        International journal of molecular sciences, 12 Feb. 2022
      • Resolution of the curse of dimensionality in single-cell RNA sequencing data analysis
        Yusuke Imoto; Tomonori Nakamura; Emerson G Escolar; Michio Yoshiwaki; Yoji Kojima; Yukihiro Yabuta; Yoshitaka Katou; Takuya Yamamoto; Yasuaki Hiraoka; Mitinori Saitou
        Life Science Alliance, Dec. 2022
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      • Single-cell RNA-seq reveals heterogeneity in hiPSC-derived muscle progenitors and E2F family as a key regulator of proliferation.
        Minas Nalbandian; Mingming Zhao; Hiroki Kato; Tatsuya Jonouchi; May Nakajima-Koyama; Takuya Yamamoto; Hidetoshi Sakurai
        Life science alliance, Aug. 2022
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      • Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin
        Ryo Ichijo; Koichiro Maki; Mio Kabata; Teruasa Murata; Arata Nagasaka; Seiichiro Ishihara; Hisashi Haga; Tetsuya Honda; Taiji Adachi; Takuya Yamamoto; Fumiko Toyoshima
        Nature Aging, 11 Jul. 2022
      • Nucleome programming is required for the foundation of totipotency in mammalian germline development
        Masahiro Nagano; Bo Hu; Shihori Yokobayashi; Akitoshi Yamamura; Fumiya Umemura; Mariel Coradin; Hiroshi Ohta; Yukihiro Yabuta; Yukiko Ishikura; Ikuhiro Okamoto; Hiroki Ikeda; Naofumi Kawahira; Yoshiaki Nosaka; Sakura Shimizu; Yoji Kojima; Ken Mizuta; Tomoko Kasahara; Yusuke Imoto; Killian Meehan; Roman Stocsits; Gordana Wutz; Yasuaki Hiraoka; Yasuhiro Murakawa; Takuya Yamamoto; Kikue Tachibana; Jan‐Michel Peters; Leonid A Mirny; Benjamin A Garcia; Jacek Majewski; Mitinori Saitou
        The EMBO Journal, 04 Jul. 2022
      • Multi-omics approach reveals posttranscriptionally regulated genes are essential for human pluripotent stem cells.
        Mio Iwasaki; Yuka Kawahara; Chikako Okubo; Tatsuya Yamakawa; Michiko Nakamura; Tsuyoshi Tabata; Yohei Nishi; Megumi Narita; Akira Ohta; Hirohide Saito; Takuya Yamamoto; Masato Nakagawa; Shinya Yamanaka; Kazutoshi Takahashi
        iScience, 20 May 2022
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      • Functional primordial germ cell-like cells from pluripotent stem cells in rats.
        Mami Oikawa; Hisato Kobayashi; Makoto Sanbo; Naoaki Mizuno; Kenyu Iwatsuki; Tomoya Takashima; Keiko Yamauchi; Fumika Yoshida; Takuya Yamamoto; Takashi Shinohara; Hiromitsu Nakauchi; Kazuki Kurimoto; Masumi Hirabayashi; Toshihiro Kobayashi
        Science (New York, N.Y.), 08 Apr. 2022
      • The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
        Kenji Ito; Kohei Nagata; Sho Ohta; Yutaka Matsuda; Tomoyo Ukai; Ichiro Yasuda; Akira Ota; Ryota Kobayashi; Mio Kabata; Nao Sankoda; Tatsuya Maeda; Knut Woltjen; Liying Yang; Reo Maruyama; Ryohei Katayama; Takuya Yamamoto; Yasuhiro Yamada
        Cell Reports, Apr. 2022
      • MYCL-mediated reprogramming expands pancreatic insulin-producing cells
        Michitada Hirano; Yusei So; Shin Tsunekawa; Mio Kabata; Sho Ohta; Hiroshi Sagara; Nao Sankoda; Jumpei Taguchi; Yosuke Yamada; Tomoyo Ukai; Makoto Kato; Jiro Nakamura; Manabu Ozawa; Takuya Yamamoto; Yasuhiro Yamada
        Nature Metabolism, 10 Feb. 2022
      • Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy
        Satoshi Kozuki; Satoko Sakurai; Atsushi Suzuki; Takuya Yamamoto; Fumiko Toyoshima
        Genes to Cells, 10 Jan. 2022
      • A versatile and robust cell purification system with an RNA-only circuit composed of microRNA-responsive ON and OFF switches.
        Yoshihiko Fujita; Moe Hirosawa; Karin Hayashi; Takeshi Hatani; Yoshinori Yoshida; Takuya Yamamoto; Hirohide Saito
        Science advances, 07 Jan. 2022
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      • DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency
        Jumpei Taguchi; Hirofumi Shibata; Mio Kabata; Masaki Kato; Kei Fukuda; Akito Tanaka; Sho Ohta; Tomoyo Ukai; Kanae Mitsunaga; Yosuke Yamada; So I Nagaoka; Sho Yamazawa; Kotaro Ohnishi; Knut Woltjen; Tetsuo Ushiku; Manabu Ozawa; Mitinori Saitou; Yoichi Shinkai; Takuya Yamamoto; Yasuhiro Yamada
        Nature Communications, Dec. 2021
      • Retinoic acid regulates erythropoietin production cooperatively with hypoxia-inducible factors in human iPSC-derived erythropoietin-producing cells
        Naoko Katagiri; Hirofumi Hitomi; Shin-Ichi Mae; Maki Kotaka; Li Lei; Takuya Yamamoto; Akira Nishiyama; Kenji Osafune
        Scientific Reports, Dec. 2021
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      • The X chromosome dosage compensation program during the development of cynomolgus monkeys.
        Ikuhiro Okamoto; Tomonori Nakamura; Kotaro Sasaki; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Shin-Ichiro Nakamura; Masatsugu Ema; Takuya Yamamoto; Mitinori Saitou
        Science (New York, N.Y.), 19 Nov. 2021
      • Inherent genomic properties underlie the epigenomic heterogeneity of human induced pluripotent stem cells
        Shihori Yokobayashi; Yukihiro Yabuta; Masato Nakagawa; Keisuke Okita; Bo Hu; Yusuke Murase; Tomonori Nakamura; Guillaume Bourque; Jacek Majewski; Takuya Yamamoto; Mitinori Saitou
        Cell Reports, Nov. 2021
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      • In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells.
        Yukiko Ishikura; Hiroshi Ohta; Takuya Sato; Yusuke Murase; Yukihiro Yabuta; Yoji Kojima; Chika Yamashiro; Tomonori Nakamura; Takuya Yamamoto; Takehiko Ogawa; Mitinori Saitou
        Cell stem cell, 01 Sep. 2021
      • Aging and CMV Infection Affect Pre-existing SARS-CoV-2-Reactive CD8+ T Cells in Unexposed Individuals
        Norihide Jo; Rui Zhang; Hideki Ueno; Takuya Yamamoto; Daniela Weiskopf; Miki Nagao; Shinya Yamanaka; Yoko Hamazaki
        Frontiers in Aging, 10 Aug. 2021
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      • The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.
        Kotaro Sasaki; Akiko Oguchi; Keren Cheng; Yasuhiro Murakawa; Ikuhiro Okamoto; Hiroshi Ohta; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Takuya Yamamoto; Yasunari Seita; Mitinori Saitou
        Cell reports, 04 May 2021
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      • Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis.
        Akinori Yuzuriha; Sou Nakamura; Naoshi Sugimoto; Shunsuke Kihara; Masato Nakagawa; Takuya Yamamoto; Kiyotoshi Sekiguchi; Koji Eto
        Stem cell research, May 2021
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      • GATA transcription factors, SOX17 and TFAP2C, drive the human germ-cell specification program.
        Yoji Kojima; Chika Yamashiro; Yusuke Murase; Yukihiro Yabuta; Ikuhiro Okamoto; Chizuru Iwatani; Hideaki Tsuchiya; Masataka Nakaya; Tomoyuki Tsukiyama; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou
        Life science alliance, May 2021
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      • Cyclosporin A and FGF signaling support the proliferation/survival of mouse primordial germ cell-like cells in vitro†.
        Hiroshi Ohta; Yukihiro Yabuta; Kazuki Kurimoto; Tomonori Nakamura; Yusuke Murase; Takuya Yamamoto; Mitinori Saitou
        Biology of reproduction, 11 Feb. 2021
      • An interplay of NOX1-derived ROS and oxygen determines the spermatogonial stem cell self-renewal efficiency under hypoxia.
        Hiroko Morimoto; Takuya Yamamoto; Takehiro Miyazaki; Narumi Ogonuki; Atsuo Ogura; Takashi Tanaka; Mito Kanatsu-Shinohara; Chihiro Yabe-Nishimura; Hongliang Zhang; Yves Pommier; Andreas Trumpp; Takashi Shinohara
        Genes & development, 01 Feb. 2021
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      • Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs
        Ryo Ichijo; Mio Kabata; Hiroyasu Kidoya; Fumitaka Muramatsu; Riki Ishibashi; Kota Abe; Ko Tsutsui; Hirokazu Kubo; Yui Iizuka; Satsuki Kitano; Hitoshi Miyachi; Yoshiaki Kubota; Hironobu Fujiwara; Aiko Sada; Takuya Yamamoto; Fumiko Toyoshima
        Science Advances, Feb. 2021
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      • Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.
        Nao Sankoda; Wataru Tanabe; Akito Tanaka; Hirofumi Shibata; Knut Woltjen; Tsutomu Chiba; Hironori Haga; Yoshiharu Sakai; Masaki Mandai; Takuya Yamamoto; Yasuhiro Yamada; Shinji Uemoto; Yoshiya Kawaguchi
        Nature communications, 25 Jan. 2021
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      • Capturing Human Trophoblast Development with Naive Pluripotent Stem Cells In Vitro
        Shingo Io; Mio Kabata; Yoshiki Iemura; Katsunori Semi; Nobuhiro Morone; Ikuhiro Okamoto; Tomonori Nakamura; Yoji Kojima; Chizuru Iwatani; Hideaki Tsuchiya; Belinda Kaswandy; Eiji Kondoh; Mitinori Saitou; Takuya Yamamoto; Masaki Mandai; Yasuhiro Takashima
        Cell Stem Cell, 18 Dec. 2020
      • Long-term expansion with germline potential of human primordial germ cell-like cells in vitro.
        Yusuke Murase; Yukihiro Yabuta; Hiroshi Ohta; Chika Yamashiro; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou
        The EMBO journal, 02 Nov. 2020
      • Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development.
        Masaki Yagi; Mio Kabata; Akito Tanaka; Tomoyo Ukai; Sho Ohta; Kazuhiko Nakabayashi; Masahito Shimizu; Kenichiro Hata; Alexander Meissner; Takuya Yamamoto; Yasuhiro Yamada
        Nature communications, 24 Jun. 2020, Peer-reviewed
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      • Recapitulating the human segmentation clock with pluripotent stem cells.
        Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Thomas L Maurissen; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Noriaki Kawakami; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev
        Nature, Apr. 2020, Peer-reviewed
      • ZGLP1 is a determinant for the oogenic fate in mice.
        So I Nagaoka; Fumio Nakaki; Hidetaka Miyauchi; Yoshiaki Nosaka; Hiroshi Ohta; Yukihiro Yabuta; Kazuki Kurimoto; Katsuhiko Hayashi; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou
        Science (New York, N.Y.), 13 Feb. 2020, Peer-reviewed
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      • RNA-binding protein ptbp1 regulates alternative splicing and transcriptome in spermatogonia and maintains spermatogenesis in concert with nanos3
        Manami Senoo; Hiroshi Hozoji; Yu Ishikawa-Yamauchi; Takashi Takijiri; Sho Ohta; Tomoyo Ukai; Mio Kabata; Takuya Yamamoto; Yasuhiro Yamada; Masahito Ikawa; Manabu Ozawa
        Journal of Reproduction and Development, 2020
      • Smarcb1 maintains the cellular identity and the chromatin landscapes of mouse embryonic stem cells.
        Sakakura M; Ohta S; Yagi M; Tanaka A; Norihide J; Woltjen K; Yamamoto T; Yamada Y
        Biochemical and biophysical research communications, Nov. 2019, Peer-reviewed
      • Induction of the Germ-Cell Fate from Pluripotent Stem Cells in Cynomolgus Monkeys.
        Sakai Y; Nakamura T; Okamoto I; Gyobu-Motani S; Ohta H; Yabuta Y; Tsukiyama T; Iwatani C; Tsuchiya H; Ema M; Morizane A; Takahashi J; Yamamoto T; Saitou M
        Biology of reproduction, Nov. 2019, Peer-reviewed
      • Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate
        Arai, Hiroyuki N; Sato, Fuminori; Yamamoto, Takuya; Woltjen, Knut; Kiyonari, Hiroshi; Yoshimoto, Yuki; Shukunami, Chisa; Akiyama, Haruhiko; Kist, Ralf; Sehara-Fujisawa, Atsuko
        CELL REPORTS, 15 Oct. 2019, Peer-reviewed
      • Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas.
        Shingo Komura; Kenji Ito; Sho Ohta; Tomoyo Ukai; Mio Kabata; Fumiaki Itakura; Katsunori Semi; Yutaka Matsuda; Kyoichi Hashimoto; Hirofumi Shibata; Masamitsu Sone; Norihide Jo; Kazuya Sekiguchi; Takatoshi Ohno; Haruhiko Akiyama; Katsuji Shimizu; Knut Woltjen; Manabu Ozawa; Junya Toguchida; Takuya Yamamoto; Yasuhiro Yamada
        Nature communications, 05 Sep. 2019, Peer-reviewed
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      • Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation.
        Mito Kanatsu-Shinohara; Takuya Yamamoto; Hidehiro Toh; Yasuhiro Kazuki; Kanako Kazuki; Junichi Imoto; Kazuho Ikeo; Motohiko Oshima; Katsuhiko Shirahige; Atsushi Iwama; Yoichi Nabeshima; Hiroyuki Sasaki; Takashi Shinohara
        Proceedings of the National Academy of Sciences of the United States of America, 13 Aug. 2019, Peer-reviewed
      • Core Transcription Factors Promote Induction of PAX3-Positive Skeletal Muscle Stem Cells.
        Takahiko Sato; Koki Higashioka; Hidetoshi Sakurai; Takuya Yamamoto; Naoki Goshima; Morio Ueno; Chie Sotozono
        Stem cell reports, 13 Aug. 2019, Peer-reviewed
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      • De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency.
        Yagi M; Kabata M; Ukai T; Ohta S; Tanaka A; Shimada Y; Sugimoto M; Araki K; Okita K; Woltjen K; Hochedlinger K; Yamamoto T; Yamada Y
        Stem cell reports, May 2019, Peer-reviewed
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      • ROS amplification drives mouse spermatogonial stem cell self-renewal.
        Hiroko Morimoto; Mito Kanastu-Shinohara; Narumi Ogonuki; Satoshi Kamimura; Atsuo Ogura; Chihiro Yabe-Nishimura; Yoshifumi Mori; Takeshi Morimoto; Satoshi Watanabe; Kinya Otsu; Takuya Yamamoto; Takashi Shinohara
        Life science alliance, Apr. 2019, Peer-reviewed
      • Human Pluripotent Stem Cell-Derived Tumor Model Uncovers the Embryonic Stem Cell Signature as a Key Driver in Atypical Teratoid/Rhabdoid Tumor.
        Yukinori Terada; Norihide Jo; Yoshiki Arakawa; Megumi Sakakura; Yosuke Yamada; Tomoyo Ukai; Mio Kabata; Kanae Mitsunaga; Yohei Mineharu; Sho Ohta; Masato Nakagawa; Susumu Miyamoto; Takuya Yamamoto; Yasuhiro Yamada
        Cell reports, 05 Mar. 2019, Peer-reviewed
      • Differentiation and isolation of iPSC-derived remodeling ductal plate-like cells by use of an AQP1-GFP reporter human iPSC line.
        Matsui S; Ochiai M; Yasuda K; Mae SI; Kotaka M; Toyoda T; Yamamoto T; Osafune K
        Stem cell research, Mar. 2019, Peer-reviewed
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      • Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis.
        Koji Hirata; Sota Kodama; Yasuhiro Nakano; Yasuko Minaki-Nakagawa; Yoshiki Aoyama; Morito Sakikubo; Toshihiko Goto; Masahiro Yoshida; Toshihiko Masui; Takuya Yamamoto; Shinji Uemoto; Yoshiya Kawaguchi
        Scientific reports, 07 Feb. 2019, Peer-reviewed
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      • Modeling the Human Segmentation Clock with Pluripotent Stem Cells
        Mitsuhiro Matsuda; Yoshihiro Yamanaka; Maya Uemura; Mitsujiro Osawa; Megumu K. Saito; Ayako Nagahashi; Megumi Nishio; Long Guo; Shiro Ikegawa; Satoko Sakurai; Shunsuke Kihara; Michiko Nakamura; Tomoko Matsumoto; Hiroyuki Yoshitomi; Makoto Ikeya; Takuya Yamamoto; Knut Woltjen; Miki Ebisuya; Junya Toguchida; Cantas Alev
        bioRxiv, Feb. 2019
      • 【代謝が変える細胞と個体の運命】分化多能性の獲得・維持と代謝
        曽根 正光; 山本 拓也
        生化学, Feb. 2019, Peer-reviewed
      • OVOL1 Influences the Determination and Expansion of iPSC Reprogramming Intermediates.
        Kagawa H; Shimamoto R; Kim SI; Oceguera-Yanez F; Yamamoto T; Schroeder T; Woltjen K
        Stem cell reports, Feb. 2019, Peer-reviewed
      • In vivo reprogramming drives Kras-induced cancer development
        Hirofumi Shibata; Shingo Komura; Yosuke Yamada; Nao Sankoda; Akito Tanaka; Tomoyo Ukai; Mio Kabata; Satoko Sakurai; Bunya Kuze; Knut Woltjen; Hironori Haga; Yatsuji Ito; Yoshiya Kawaguchi; Takuya Yamamoto; Yasuhiro Yamada
        Nature Communications, 01 Dec. 2018, Peer-reviewed
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      • Generation of human oogonia from induced pluripotent stem cells in vitro.
        Yamashiro C; Sasaki K; Yabuta Y; Kojima Y; Nakamura T; Okamoto I; Yokobayashi S; Murase Y; Ishikura Y; Shirane K; Sasaki H; Yamamoto T; Saitou M
        Science (New York, N.Y.), Oct. 2018, Peer-reviewed
      • A β1-tubulin-based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production.
        Hideya Seo; Si Jing Chen; Kazuya Hashimoto; Hiroshi Endo; Yohei Nishi; Akira Ohta; Takuya Yamamoto; Akitsu Hotta; Akira Sawaguchi; Hideki Hayashi; Noritaka Koseki; George J Murphy; Kazuhiko Fukuda; Naoshi Sugimoto; Koji Eto
        Blood advances, 11 Sep. 2018, Peer-reviewed
      • Unveiling epigenetic regulation in cancer, aging, and rejuvenation with in vivo reprogramming technology.
        Sogabe Y; Seno H; Yamamoto T; Yamada Y
        Cancer science, Sep. 2018, Peer-reviewed
      • Turbulence Activates Platelet Biogenesis to Enable Clinical Scale Ex Vivo Production.
        Yukitaka Ito; Sou Nakamura; Naoshi Sugimoto; Tomohiro Shigemori; Yoshikazu Kato; Mikiko Ohno; Shinya Sakuma; Keitaro Ito; Hiroki Kumon; Hidenori Hirose; Haruki Okamoto; Masayuki Nogawa; Mio Iwasaki; Shunsuke Kihara; Kosuke Fujio; Takuya Matsumoto; Natsumi Higashi; Kazuya Hashimoto; Akira Sawaguchi; Ken-Ichi Harimoto; Masato Nakagawa; Takuya Yamamoto; Makoto Handa; Naohide Watanabe; Eiichiro Nishi; Fumihito Arai; Satoshi Nishimura; Koji Eto
        Cell, 26 Jul. 2018, Peer-reviewed
      • Srf destabilizes cellular identity by suppressing cell-type-specific gene expression programs.
        Takashi Ikeda; Takafusa Hikichi; Hisashi Miura; Hirofumi Shibata; Kanae Mitsunaga; Yosuke Yamada; Knut Woltjen; Kei Miyamoto; Ichiro Hiratani; Yasuhiro Yamada; Akitsu Hotta; Takuya Yamamoto; Keisuke Okita; Shinji Masui
        Nature communications, 11 Apr. 2018, Peer-reviewed
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      • Principles for the regulation of multiple developmental pathways by a versatile transcriptional factor, BLIMP1
        Tadahiro Mitani; Yukihiro Yabuta; Hiroshi Ohta; Tomonori Nakamura; Chika Yamashiro; Takuya Yamamoto; Mitinori Saitou; Kazuki Kurimoto
        NUCLEIC ACIDS RESEARCH, Dec. 2017, Peer-reviewed
      • The Sexual Dimorphism of Dietary Restriction Responsiveness in Caenorhabditis elegans
        Sakiko Honjoh; Akiko Ihara; Yukiko Kajiwara; Takuya Yamamoto; Eisuke Nishida
        CELL REPORTS, Dec. 2017, Peer-reviewed
      • Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice.
        Hidetaka Miyauchi; Hiroshi Ohta; So Nagaoka; Fumio Nakaki; Kotaro Sasaki; Katsuhiko Hayashi; Yukihiro Yabuta; Tomonori Nakamura; Takuya Yamamoto; Mitinori Saitou
        The EMBO journal, 02 Nov. 2017, Peer-reviewed
      • Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells
        Hiroki Ikeda; Masamitsu Sone; Shinya Yamanaka; Takuya Yamamoto
        NATURE COMMUNICATIONS, Nov. 2017, Peer-reviewed
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      • Evolutionarily Distinctive Transcriptional and Signaling Programs Drive Human Germ Cell Lineage Specification from Pluripotent Stem Cells.
        Yoji Kojima; Kotaro Sasaki; Shihori Yokobayashi; Yoshitake Sakai; Tomonori Nakamura; Yukihiro Yabuta; Fumio Nakaki; So Nagaoka; Knut Woltjen; Akitsu Hotta; Takuya Yamamoto; Mitinori Saitou
        Cell stem cell, 05 Oct. 2017, Peer-reviewed
      • Antisense Oligonucleotides Reduce RNA Foci in Spinocerebellar Ataxia 36 Patient iPSCs.
        Kosuke Matsuzono; Keiko Imamura; Nagahisa Murakami; Kayoko Tsukita; Takuya Yamamoto; Yuishin Izumi; Ryuji Kaji; Yasuyuki Ohta; Toru Yamashita; Koji Abe; Haruhisa Inoue
        Molecular therapy. Nucleic acids, 15 Sep. 2017, Peer-reviewed
      • Analysis of neural crest cells from Charcot-Marie-Tooth disease patients demonstrates disease-relevant molecular signature
        Fukiko Kitani-Morii; Keiko Imamura; Takayuki Kondo; Ryo Ohara; Takako Enami; Ran Shibukawa; Takuya Yamamoto; Kazuya Sekiguchi; Junya Toguchida; Toshiki Mizuno; Masanori Nakagawa; Haruhisa Inoue
        NEUROREPORT, Sep. 2017, Peer-reviewed
      • Antagonistic Interactions between Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase and Retinoic Acid Receptor Signaling in Colorectal Cancer Cells
        Masamichi Imajo; Kunio Kondoh; Takuya Yamamoto; Kei Nakayama; May Nakajima-Koyama; Eisuke Nishida
        MOLECULAR AND CELLULAR BIOLOGY, Aug. 2017, Peer-reviewed
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      • Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation
        Masaki Yagi; Satoshi Kishigami; Akito Tanaka; Katsunori Semi; Eiji Mizutani; Sayaka Wakayama; Teruhiko Wakayama; Takuya Yamamoto; Yasuhiro Yamada
        NATURE, Aug. 2017, Peer-reviewed
      • iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons.
        Imamura K; Izumi Y; Watanabe A; Tsukita K; Woltjen K; Yamamoto T; Hotta A; Kondo T; Kitaoka S; Ohta A; Tanaka A; Watanabe D; Morita M; Kaji R; Takuma H; Tamaoka A; Kunath T; Wray S; Furuya H; Era T; Fujisawa T; Nishotoh H; Kengo H; Ichijo H; Julien J-P; Obata N; Hosokawa M; Akiyama H; Ayaki T; Ito H; Takahashi R; Yamanaka S; Inoue H
        Science Translational Medicine, May 2017, Peer-reviewed
      • Hybrid Cellular Metabolism Coordinated by Zic3 and Esrrb Synergistically Enhances Induction of Naive Pluripotency
        Masamitsu Sone; Nobuhiro Morone; Tomonori Nakamura; Akito Tanaka; Keisuke Okita; Knut Woltjen; Masato Nakagawa; John E. Heuser; Yasuhiro Yamada; Shinya Yamanaka; Takuya Yamamoto
        Cell Metabolism, May 2017, Peer-reviewed
      • The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis
        Keiko Imamura; Yuishin Izumi; Akira Watanabe; Kayoko Tsukita; Knut Woltjen; Takuya Yamamoto; Akitsu Hotta; Takayuki Kondo; Shiho Kitaoka; Akira Ohta; Akito Tanaka; Dai Watanabe; Mitsuya Morita; Hiroshi Takuma; Akira Tamaoka; Tilo Kunath; Selina Wray; Hirokazu Furuya; Takumi Era; Kouki Makioka; Koichi Okamoto; Takao Fujisawa; Hideki Nishitoh; Kengo Homma; Hidenori Ichijo; Jean-Pierre Julien; Nanako Obata; Masato Hosokawa; Haruhiko Akiyama; Satoshi Kaneko; Takashi Ayaki; Hidefumi Ito; Ryuji Kaji; Ryosuke Takahashi; Shinya Yamanaka; Haruhisa Inoue
        SCIENCE TRANSLATIONAL MEDICINE, May 2017, Peer-reviewed
      • In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.
        Ohta H; Kurimoto K; Okamoto I; Nakamura T; Yabuta Y; Miyauchi H; Yamamoto T; Okuno Y; Hagiwara M; Shirane K; Sasaki H; Saitou M
        The EMBO journal, May 2017, Peer-reviewed
      • Clonal Variation of Human Induced Pluripotent Stem Cells for Induction into the Germ Cell Fate.
        Yokobayashi S; Okita K; Nakagawa M; Nakamura T; Yabuta Y; Yamamoto T; Saitou M
        Biology of reproduction, Apr. 2017, Peer-reviewed
      • Discrimination of Stem Cell Status after Subjecting Cynomolgus Monkey Pluripotent Stem Cells to Naïve Conversion.
        Honda A; Kawano Y; Izu H; Choijookhuu N; Honsho K; Nakamura T; Yabuta Y; Yamamoto T; Takashima Y; Hirose M; Sankai T; Hishikawa Y; Ogura A; Saitou M
        Scientific reports, Mar. 2017, Peer-reviewed
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      • Activin A in combination with ERK1/2 MAPK pathway inhibition sustains propagation of mouse embryonic stem cells
        Yuhei Ashida; May Nakajima-Koyama; Akira Hirota; Takuya Yamamoto; Eisuke Nishida
        GENES TO CELLS, Feb. 2017, Peer-reviewed
      • Proteasome impairment in neural cells derived from HMSN-P patient iPSCs
        Nagahisa Murakami; Keiko Imamura; Yuishin Izumi; Naohiro Egawa; Kayoko Tsukita; Takako Enami; Takuya Yamamoto; Toshitaka Kawarai; Ryuji Kaji; Haruhisa Inoue
        MOLECULAR BRAIN, Feb. 2017, Peer-reviewed
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      • Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells
        Hayami Sugiyama; Kazutoshi Takahashi; Takuya Yamamoto; Mio Iwasaki; Megumi Narita; Masahiro Nakamura; Tim A. Rand; Masato Nakagawa; Akira Watanabe; Shinya Yamanaka
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2017, Peer-reviewed
      • Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior
        Kyoichi Hashimoto; Yosuke Yamada; Katsunori Semi; Masaki Yagi; Akito Tanaka; Fumiaki Itakura; Hitomi Aoki; Takahiro Kunisada; Knut Woltjen; Hironori Haga; Yoshiharu Sakai; Takuya Yamamoto; Yasuhiro Yamada
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2017, Peer-reviewed
      • In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells.
        Ishikura Y; Yabuta Y; Ohta H; Hayashi K; Nakamura T; Okamoto I; Yamamoto T; Kurimoto K; Shirane K; Sasaki H; Saitou M
        Cell reports, Dec. 2016, Peer-reviewed
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      • Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies
        Yukinori Hirano; Kunio Ihara; Tomoko Masuda; Takuya Yamamoto; Ikuko Iwata; Aya Takahashi; Hiroko Awata; Naosuke Nakamura; Mai Takakura; Yusuke Suzuki; Junjiro Horiuchi; Hiroyuki Okuno; Minoru Saitoe
        NATURE COMMUNICATIONS, Nov. 2016, Peer-reviewed
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      • The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion.
        Sasaki K; Nakamura T; Okamoto I; Yabuta Y; Iwatani C; Tsuchiya H; Seita Y; Nakamura S; Shiraki N; Takakuwa T; Yamamoto T; Saitou M
        Developmental cell, Oct. 2016, Peer-reviewed
      • A developmental coordinate of pluripotency among mice, monkeys and humans.
        Nakamura T; Okamoto I; Sasaki K; Yabuta Y; Iwatani C; Tsuchiya H; Seita Y; Nakamura S; Yamamoto T; Saitou M
        Nature, Aug. 2016, Peer-reviewed
      • Identification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models
        Tomonaga Ameku; Daisuke Taura; Masakatsu Sone; Tomohiro Numata; Masahiro Nakamura; Fumihiko Shiota; Taro Toyoda; Satoshi Matsui; Toshikazu Araoka; Tetsuhiko Yasuno; Shin-Ichi Mae; Hatasu Kobayashi; Naoya Kondo; Fumiyo Kitaoka; Naoki Amano; Sayaka Arai; Tomoko Ichisaka; Norio Matsuura; Sumiko Inoue; Takuya Yamamoto; Kazutoshi Takahashi; Isao Asaka; Yasuhiro Yamada; Yoshifumi Ubara; Eri Muso; Atsushi Fukatsu; Akira Watanabe; Yasunori Sato; Tatsutoshi Nakahata; Yasuo Mori; Akio Koizumi; Kazuwa Nakao; Shinya Yamanaka; Kenji Osafune
        SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed
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      • An EWS-FLI1-Induced Osteosarcoma Model Unveiled a Crucial Role of Impaired Osteogenic Differentiation on Osteosarcoma Development
        Shingo Komura; Katsunori Semi; Fumiaki Itakura; Hirofumi Shibata; Takatoshi Ohno; Akitsu Hotta; Knut Woltjen; Takuya Yamamoto; Haruhiko Akiyama; Yasuhiro Yamada
        STEM CELL REPORTS, Apr. 2016, Peer-reviewed
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      • Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice.
        Chika Yamashiro; Takayuki Hirota; Kazuki Kurimoto; Tomonori Nakamura; Yukihiro Yabuta; So I Nagaoka; Hiroshi Ohta; Takuya Yamamoto; Mitinori Saitou
        Biology of reproduction, Jan. 2016, Peer-reviewed
      • Induction of Pluripotency in Astrocytes through a Neural Stem Cell-like State
        May Nakajima-Koyama; Joonseong Lee; Sho Ohta; Takuya Yamamoto; Eisuke Nishida
        JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2015, Peer-reviewed
      • Secreted Ephrin Receptor A7 Promotes Somatic Cell Reprogramming by Inducing ERK Activity Reduction
        Joonseong Lee; May Nakajima-Koyama; Masamitsu Sone; Makito Koga; Miki Ebisuya; Takuya Yamamoto; Eisuke Nishida
        STEM CELL REPORTS, Oct. 2015, Peer-reviewed
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      • Robust In Vitro Induction of Human Germ Cell Fate from Pluripotent Stem Cells.
        Sasaki K; Yokobayashi S; Nakamura T; Okamoto I; Yabuta Y; Kurimoto K; Ohta H; Moritoki Y; Iwatani C; Tsuchiya H; Nakamura S; Sekiguchi K; Sakuma T; Yamamoto T; Mori T; Woltjen K; Nakagawa M; Yamamoto T; Takahashi K; Yamanaka S
        Cell stem cell, Aug. 2015, Peer-reviewed
      • New Protocol to Optimize iPS Cells for Genome Analysis of Fibrodysplasia Ossificans Progressiva
        Yoshihisa Matsumoto; Makoto Ikeya; Kyosuke Hino; Kazuhiko Horigome; Makoto Fukuta; Makoto Watanabe; Sanae Nagata; Takuya Yamamoto; Takanobu Otsuka; Junya Toguchida
        STEM CELLS, Jun. 2015, Peer-reviewed
      • SC3-seq: a method for highly parallel and quantitative measurement of single-cell gene expression.
        Nakamura T; Yabuta Y; Okamoto I; Aramaki S; Yokobayashi S; Kurimoto K; Sekiguchi K; Nakagawa M; Yamamoto T; Saitou M
        Nucleic acids research, May 2015, Peer-reviewed
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      • Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells
        Kazuki Kurimoto; Yukihiro Yabuta; Katsuhiko Hayashi; Hiroshi Ohta; Hiroshi Kiyonari; Tadahiro Mitani; Yoshinobu Moritoki; Kenjiro Kohri; Hiroshi Kimura; Takuya Yamamoto; Yuki Katou; Katsuhiko Shirahige; Mitinori Saitou
        CELL STEM CELL, May 2015, Peer-reviewed
      • KLF4 N-Terminal Variance Modulates Induced Reprogramming to Pluripotency
        Shin-Il Kim; Fabian Oceguera-Yanez; Ryoko Hirohata; Sara Linker; Keisuke Okita; Yasuhiro Yamada; Takuya Yamamoto; Shinya Yamanaka; Knut Woltjen
        STEM CELL REPORTS, Apr. 2015, Peer-reviewed
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      • 体細胞初期化過程における選択的スプライシングの変化とその分子機構
        太田 翔; 山本 拓也
        生化学, Dec. 2014, Peer-reviewed, Invited
      • Derivation of Mesenchymal Stromal Cells from Pluripotent Stem Cells through a Neural Crest Lineage using Small Molecule Compounds with Defined Media
        Makoto Fukuta; Yoshinori Nakai; Kosuke Kirino; Masato Nakagawa; Kazuya Sekiguchi; Sanae Nagata; Yoshihisa Matsumoto; Takuya Yamamoto; Katsutsugu Umeda; Toshio Heike; Naoki Okumura; Noriko Koizumi; Takahiko Sato; Tatsutoshi Nakahata; Megumu Saito; Takanobu Otsuka; Shigeru Kinoshita; Morio Ueno; Makoto Ikeya; Junya Toguchida
        PLOS ONE, Dec. 2014, Peer-reviewed
      • miR-195/497 induce postnatal quiescence of skeletal muscle stem cells
        Takahiko Sato; Takuya Yamamoto; Atsuko Sehara-Fujisawa
        NATURE COMMUNICATIONS, Aug. 2014, Peer-reviewed
      • Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation
        Kotaro Ohnishi; Katsunori Semi; Takuya Yamamoto; Masahito Shimizu; Akito Tanaka; Kanae Mitsunaga; Keisuke Okita; Kenji Osafune; Yuko Arioka; Toshiyuki Maeda; Hidenobu Soejima; Hisataka Moriwaki; Shinya Yamanaka; Knut Woltjen; Yasuhiro Yamada
        CELL, Feb. 2014, Peer-reviewed
      • Global Splicing Pattern Reversion during Somatic Cell Reprogramming
        Sho Ohta; Eisuke Nishida; Shinya Yamanaka; Takuya Yamamoto
        CELL REPORTS, Oct. 2013, Peer-reviewed
      • Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".
        Naohiro Egawa; Shiho Kitaoka; Kayoko Tsukita; Motoko Naitoh; Kazutoshi Takahashi; Takuya Yamamoto; Fumihiko Adachi; Takayuki Kondo; Keisuke Okita; Isao Asaka; Takashi Aoi; Akira Watanabe; Yasuhiro Yamada; Asuka Morizane; Jun Takahashi; Takashi Ayaki; Hidefumi Ito; Katsuhiro Yoshikawa; Satoko Yamawaki; Shigehiko Suzuki; Dai Watanabe; Hiroyuki Hioki; Takeshi Kaneko; Kouki Makioka; Koichi Okamoto; Hiroshi Takuma; Akira Tamaoka; Kazuko Hasegawa; Takashi Nonaka; Masato Hasegawa; Akihiro Kawata; Minoru Yoshida; Tatsutoshi Nakahata; Ryosuke Takahashi; Maria C N Marchetto; Fred H Gage; Shinya Yamanaka; Haruhisa Inoue
        Science translational medicine, 05 Jun. 2013, Peer-reviewed
      • Fetal Skeletal Muscle Progenitors Have Regenerative Capacity after Intramuscular Engraftment in Dystrophin Deficient Mice
        Hiroshi Sakai; Takahiko Sato; Hidetoshi Sakurai; Takuya Yamamoto; Kazunori Hanaoka; Didier Montarras; Atsuko Sehara-Fujisawa
        PLOS ONE, May 2013, Peer-reviewed
        Access this paper :
      • Efficient and Reproducible Myogenic Differentiation from Human iPS Cells: Prospects for Modeling Miyoshi Myopathy In Vitro
        Akihito Tanaka; Knut Woltjen; Katsuya Miyake; Akitsu Hotta; Makoto Ikeya; Takuya Yamamoto; Tokiko Nishino; Emi Shoji; Atsuko Sehara-Fujisawa; Yasuko Manabe; Nobuharu Fujii; Kazunori Hanaoka; Takumi Era; Satoshi Yamashita; Ken-ichi Isobe; En Kimura; Hidetoshi Sakurai
        PLOS ONE, Apr. 2013, Peer-reviewed
        Access this paper :
      • Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles
        Takafusa Hikichi; Ryo Matoba; Takashi Ikeda; Akira Watanabe; Takuya Yamamoto; Satoko Yoshitake; Miwa Tamura-Nakano; Takayuki Kimura; Masayoshi Kamon; Mari Shimura; Koichi Kawakami; Akihiko Okuda; Hitoshi Okochi; Takafumi Inoue; Atsushi Suzuki; Shinji Masui
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2013, Peer-reviewed
        Access this paper :
      • Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin
        Akira Nasu; Makoto Ikeya; Takuya Yamamoto; Akira Watanabe; Yonghui Jin; Yoshihisa Matsumoto; Kazuo Hayakawa; Naoki Amano; Shingo Sato; Kenji Osafune; Tomoki Aoyama; Takashi Nakamura; Tomohisa Kato; Junya Toguchida
        PLOS ONE, Jan. 2013, Peer-reviewed
      • A Fasting-Responsive Signaling Pathway that Extends Life Span in C. elegans
        Masaharu Uno; Sakiko Honjoh; Mitsuhiro Matsuda; Haruka Hoshikawa; Saya Kishimoto; Tomohito Yamamoto; Miki Ebisuya; Takuya Yamamoto; Kunihiro Matsumoto; Eisuke Nishida
        CELL REPORTS, Jan. 2013, Peer-reviewed
      • Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium
        A. Hirata; J. Utikal; S. Yamashita; H. Aoki; A. Watanabe; T. Yamamoto; H. Okano; N. Bardeesy; T. Kunisada; T. Ushijima; A. Hara; R. Jaenisch; K. Hochedlinger; Y. Yamada
        Development (Cambridge), 2013, Peer-reviewed
      • A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions
        Itsunari Minami; Kohei Yamada; Tomomi G. Otsuji; Takuya Yamamoto; Yan Shen; Shinya Otsuka; Shin Kadota; Nobuhiro Morone; Maneesha Barve; Yasuyuki Asai; Tatyana Tenkova-Heuser; John E. Heuser; Motonari Uesugi; Kazuhiro Aiba; Norio Nakatsuji
        CELL REPORTS, Nov. 2012, Peer-reviewed
      • Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery
        Takayuki Tanaka; Kazutoshi Takahashi; Mayu Yamane; Shota Tomida; Saori Nakamura; Koichi Oshima; Akira Niwa; Ryuta Nishikomori; Naotomo Kambe; Hideki Hara; Masao Mitsuyama; Nobuhiro Morone; John E. Heuser; Takuya Yamamoto; Akira Watanabe; Aiko Sato-Otsubo; Seishi Ogawa; Isao Asaka; Toshio Heike; Shinya Yamanaka; Tatsutoshi Nakahata; Megumu K. Saito
        BLOOD, Aug. 2012, Peer-reviewed
      • Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells
        Naohiro Egawa; Shiho Kitaoka; Kayoko Tsukita; Motoko Naitoh; Kazutoshi Takahashi; Takuya Yamamoto; Fumihiko Adachi; Takayuki Kondo; Keisuke Okita; Isao Asaka; Takashi Aoi; Akira Watanabe; Yasuhiro Yamada; Asuka Morizane; Jun Takahashi; Takashi Ayaki; Hidefumi Ito; Katsuhiro Yoshikawa; Satoko Yamawaki; Shigehiko Suzuki; Dai Watanabe; Hiroyuki Hioki; Takeshi Kaneko; Kouki Makioka; Koichi Okamoto; Hiroshi Takuma; Akira Tamaoka; Kazuko Hasegawa; Takashi Nonaka; Masato Hasegawa; Akihiro Kawata; Minoru Yoshida; Tatsutoshi Nakahata; Ryosuke Takahashi; Maria C. N. Marchetto; Fred H. Gage; Shinya Yamanaka; Haruhisa Inoue
        SCIENCE TRANSLATIONAL MEDICINE, Aug. 2012, Peer-reviewed
      • ABL1 regulates spindle orientation in adherent cells and mammalian skin
        Shigeru Matsumura; Mayumi Hamasaki; Takuya Yamamoto; Miki Ebisuya; Mizuho Sato; Eisuke Nishida; Fumiko Toyoshima
        NATURE COMMUNICATIONS, Jan. 2012, Peer-reviewed
      • ERK5 Regulates Muscle Cell Fusion through Klf Transcription Factors
        Kazunori Sunadome; Takuya Yamamoto; Miki Ebisuya; Kunio Kondoh; Atsuko Sehara-Fujisawa; Eisuke Nishida
        DEVELOPMENTAL CELL, Feb. 2011, Peer-reviewed
      • The Kinase SGK1 in the Endoderm and Mesoderm Promotes Ectodermal Survival by Down-Regulating Components of the Death-Inducing Signaling Complex
        Tatsuya Endo; Morioh Kusakabe; Kazunori Sunadome; Takuya Yamamoto; Eisuke Nishida
        SCIENCE SIGNALING, Jan. 2011, Peer-reviewed
      • Revolving movement of a dynamic cluster of actin filaments during mitosis
        Masaru Mitsushima; Kazuhiro Aoki; Miki Ebisuya; Shigeru Matsumura; Takuya Yamamoto; Michiyuki Matsuda; Fumiko Toyoshima; Eisuke Nishida
        JOURNAL OF CELL BIOLOGY, Nov. 2010, Peer-reviewed
      • Noninvasive method for assessing the human circadian clock using hair follicle cells
        Makoto Akashi; Haruhiko Soma; Takuro Yamamoto; Asuka Tsugitomi; Shiko Yamashita; Takuya Yamamoto; Eisuke Nishida; Akio Yasuda; James K. Liao; Koichi Node
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2010, Peer-reviewed
      • Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C-elegans
        Sakiko Honjoh; Takuya Yamamoto; Masaharu Uno; Eisuke Nishida
        NATURE, Feb. 2009, Peer-reviewed
      • Ripples from neighbouring transcription
        Miki Ebisuya; Takuya Yamamoto; May Nakajima; Eisuke Nishida
        NATURE CELL BIOLOGY, Sep. 2008, Peer-reviewed
      • Requirement for ERK MAP kinase in mouse preimplantation development
        Momoko Maekawa; Takuya Yamamoto; Michiaki Kohno; Masatoshi Takeichi; Eisuke Nishida
        DEVELOPMENT, Aug. 2007, Peer-reviewed
      • ERK MAP kinase in G cell cycle progression and cancer.
        Satoru Torii; Takuya Yamamoto; Yoshiki Tsuchiya; Eisuke Nishida
        Cancer science, Aug. 2006, Peer-reviewed
      • Continuous ERK activation downregulates anti proliferative genes throughout G1 phase to allow cell-cycle progression
        T Yamamoto; M Ebisuya; F Ashida; K Okamoto; S Yonehara; E Nishida
        CURRENT BIOLOGY, Jun. 2006, Peer-reviewed
      • Requirement of the MAP kinase signaling pathways for mouse preimplantation development
        M Maekawa; T Yamamoto; T Tanoue; Y Yuasa; O Chisaka; E Nishida
        DEVELOPMENT, Apr. 2005, Peer-reviewed
      • Regulatory mechanisms and function of ERK MAP kinases
        S Torii; K Nakayama; T Yamamoto; E Nishida
        JOURNAL OF BIOCHEMISTRY, Nov. 2004, Peer-reviewed
      • Sef is a spatial regulator for Ras/MAP kinase signaling
        S Torii; M Kusakabe; T Yamamoto; M Maekawa; E Nishida
        DEVELOPMENTAL CELL, Jul. 2004, Peer-reviewed
      • Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences
        M Maekawa; T Yamamoto; E Nishida
        EXPERIMENTAL CELL RESEARCH, Apr. 2004, Peer-reviewed
      • Modular structure of a docking surface on MAPK phosphatases
        T Tanoue; T Yamamoto; E Nishida
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2002, Peer-reviewed
      • A novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs
        T Tanoue; T Yamamoto; R Maeda; E Nishida
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2001, Peer-reviewed

      Misc.

      • 炎症性微小環境、三次リンパ組織の腎組織障害メカニズムの解明
        好川 貴久; 小口 綾貴子; 鳥生 直哉; 佐藤 有紀; 山本 拓也; 村川 泰裕; 柳田 素子
        日本臨床分子医学会学術総会プログラム・抄録集, Apr. 2024
      • ハダカデバネズミ由来神経幹細胞の樹立とDNA修復能の解析
        山村祐紀; 河村佳見; 大岩祐基; 岡香織; 大西伸幸; 山本拓也; 三浦恭子
        日本遺伝学会大会プログラム・予稿集, 2020
      • EWS/ATF1融合遺伝子は細胞種特異的なエンハンサーに結合して明細胞肉腫を発生させる
        河村真吾; 伊藤謙治; 大野貴敏; 清水克時; WOLTJEN Knut; 小沢学; 戸口田淳也; 山本拓也; 秋山治彦; 山田泰広
        日本整形外科学会雑誌, 2022
      • EWS/ATF1融合遺伝子は細胞種特異的なエンハンサーに結合して明細胞肉腫を発生させる
        河村真吾; 伊藤謙治; 大野貴敏; 清水克時; WOLTJEN Knut; 小沢学; 戸口田淳也; 山本拓也; 秋山治彦; 山田泰広
        日本整形外科学会雑誌, 2020
      • マウスEWS/FLI1誘導性骨肉腫モデルが明らかとした肉腫発生に関わる重要事項-EWS/FLI1とcancer genomeがもたらす細胞分化異常-
        河村真吾; 河村真吾; 蝉克憲; 板倉史晃; 柴田博史; 堀田秋津; WOLTJEN Knut; 山本拓也; 大野貴敏; 秋山治彦; 山田泰広
        日本整形外科学会雑誌, 2016
      • マウスEWS/FLI1誘導性骨肉腫モデルが明らかとした肉腫発生に関わる重要事項-EWS/FLI1とcancer genomeがもたらす細胞分化異常-
        河村真吾; 河村真吾; 蝉克憲; 板倉史晃; 柴田博史; 堀田秋津; WOLTJEN Knut; 山本拓也; 大野貴敏; 秋山治彦; 山田泰広
        日本整形外科学会雑誌, 2016
      • EWS-FLI1誘導性骨肉腫モデルによって骨分化障害が肉腫発生に重要な役割をもつことが明らかとなった
        河村真吾; 蝉克憲; 板倉史晃; 柴田博史; 堀田秋津; KNUT Woltjen; 山本拓也; 大野貴敏; 秋山治彦; 山田泰広
        日本整形外科学会雑誌, 2016
      • Cancer resistance in naked mole-rats via a dampened inflammatory response
        藤岡周助; 藤岡周助; 岡香織; 河村佳見; 河村佳見; 菰原義弘; 中條岳志; 山村祐紀; 大岩祐基; 須藤洋一; 小巻翔平; 大豆生田夏子; 櫻井智子; 清水厚志; 坊農秀雅; 富澤一仁; 山本拓也; 山田泰広; 押海裕之; 三浦恭子; 三浦恭子
        日本薬学会年会要旨集(Web), Mar. 2021
      • Generation of human oogonia from induced pluripotent stem cells in vitro
        Chika Yamashiro; Kotaro Sasaki; Yukihiro Yabuta; Yoji Kojima; Tomonori Nakamura; Ikuhiro Okamoto; Shihori Yokobayashi; Yusuke Murase; Yukiko Ishikura; Kenjiro Shirane; Hiroyuki Sasaki; Takuya Yamamoto; Mitinori Saitou
        Obstetrical and Gynecological Survey, 01 Mar. 2019
      • Disease Modeling of Pituitary Adenoma Using Human Pluripotent Stem Cells
        Ryusaku Matsumoto; Hidetaka Suga; Hiroshi Arima; Takuya Yamamoto
        Cancers, Aug. 2022
      • Complex organ construction from human pluripotent stem cells for biological research and disease modeling with new emerging techniques
        Ryusaku Matsumoto; Takuya Yamamoto; Yutaka Takahashi
        International Journal of Molecular Sciences, Oct. 2021
      • iPSC model for demyelinating Charcot-Marie-Tooth disease
        Kitani-Morii F; Imamura K; Kondo T; Ohara R; Yamamoto T; Sekiguchi K; Toguchida J; Mizuno T; Nakagawa M; Inoue H
        58th Annual Meeting of the Japanese Society of Neurology, Kyoto., 16 Sep. 2017
      • Hybrid cellular metabolism coordinated by Zic3 and Esrrb synergistically enhances somatic cell reprogramming.
        Masamitsu Sone; Shinya Yamanaka; Takuya Yamamoto
        ISSCR 2017, Boston, USA, June 14-17, 2017, Jun. 2017, Peer-reviewed
      • Synthetic miRNA Switch Technology Elucidates Heterogeneity in Regulation of Immortalized Megakaryocyte Cell Lines, Associated with Improvement of Platelet Generation Efficiency for Clinical Use
        Kazuya Hashimoto; Satoshi Matsuura; Yoshihiko Fujita; Karin Hayashi; Naoshi Sugimoto; Takuya Yamamoto; Hirohide Saito; Koji Eto
        BLOOD, Dec. 2016
      • ORPHAN NUCLEAR RECEPTOR AND ZIC FAMILY TRANSCRPTION FACTORS SYNERGISTICALLY ENHANCE SOMATIC CELL REPROGRAMMING
        Sone M; Yamanaka S; Yamamoto T
        第13 回ISSCR（2015.6.24-27 ストックホルム）, Jun. 2015, Peer-reviewed
      • CHROMATIN INTERACTIONS AT DEVELOPMENTAL GENE LOCI ARE REESTABLISHED BY SOMATIC CELL REPROGRAMMING
        Hiroki Ikeda; Masamitsu Sone; Shinya Yamanaka; Takuya Yamamoto
        第13 回ISSCR（2015.6.24-27 ストックホルム）, Jun. 2015, Peer-reviewed
      • Genomic correction of mutant TDP-43 iPSCs
        Tsuge I; Tsukita K; Naito M; Suzuki S; Sakuma T; Yamamoto T; Hotta A; Yamanaka S; Inoue H
        56th Annual Meeting of the Japanese Society of Neurology, Niigata., 21 May 2015
      • ANALYSIS OF LONG-RANGE CHROMATIN INTERACTION NETWORKS IN PLURIPOTENT STEM CELLS
        Hiroki Ikeda; Masamitsu Sone; Shinya Yamanaka; Takuya Yamamoto
        第12 回ISSCR（2014.6.18-21 バンクーバー）, Jun. 2014, Peer-reviewed
      • RNA splicing regulation during somatic cell reprogramming
        Ohta S; Nishida E; Yamanaka S; Yamamoto T
        第11 回ISSCR（2013.6.12-15 ボストン）, Jul. 2013, Peer-reviewed
      • Exploration of chromatin interactions in pluripotent stem cells
        Hiroki Ikeda; Masamitsu Sone; Shinya Yamanaka; Takuya Yamamoto
        第11 回ISSCR（2013.6.12-15 ボストン）, Jun. 2013, Peer-reviewed
      • Inferring the transcription networks required for induction of pluripotecy
        Sone M; Yamanaka S; Yamamoto T
        第10 回ISSCR（2012.6.13-16．横浜）, Jun. 2013, Peer-reviewed
      • Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles
        Hikichi Takafusa; Matoba Ryo; Ikeda Takashi; Watanabe Akira; Yamamoto Takuya; Yoshitake Satoko; Tamura-Nakano Miwa; Kimura Takayuki; Kamon Masayoshi; Shimura Mari; Kawakami Koichi; Okuda Akihiko; Okochi Hitoshi; Inoue Takafumi; Suzuki Atsushi; Masui Shinji
        Proceedings of the National Academy of Sciences of the United States of America, 02 Apr. 2013
        Access this misc :
      • Dynamic alteration in rna splicing during somatic cell reprogramming
        Ohta S; Nishida E; Yamanaka S; Yamamoto T
        第10 回ISSCR（2012.6.13-16．横浜）, Jun. 2012, Peer-reviewed
      • Global analysis of higher-order chromatin structure in pluripotent stem cells
        Ikeda H; Sone M; Yamanaka S; Yamamoto T
        第10 回ISSCR（2012.6.13-16．横浜）, Jun. 2012
      • Genetically matched human iPS cells revealed that the propensity for iPS cells to differentiate into cartilage lineage cells differs with clones, but not cell type of origin
        Nasu A; Kato T; Yamamoto T; Ikeya M; Toguchida J
        第10 回ISSCR（2012.6.15．横浜）, Jun. 2012, Peer-reviewed
      • 同一ドナーの異なる組織より樹立したiPS 細胞の比較検討
        那須輝; 加藤友久; 山本拓也; 中村孝志; 池谷真; 戸口田淳也
        第11 回日本再生医療学会（2012.6.13．横浜）, 2012, Peer-reviewed
      • Global changes of splicing regulation in the reprogramming process
        Ohta S; Nishida E; Yamanaka S; Yamamoto T
        第34回日本分子生物学会年会、パシフィコ横浜、2011.12.13-16, Dec. 2011, Peer-reviewed
      • 体細胞初期化過程における選択的スプライシング制御機構の解明
        太田翔; 西田栄介; 山中伸弥; 山本拓也
        第84回日本生化学会大会、京都 2011.9.21-24., Sep. 2011, Peer-reviewed
      • ABL1による 細胞分裂軸方向の制御機構
        松村繁; 濱崎真弓; 山本拓也; 戎家美紀; 佐藤みずほ; 西田栄介; 豊島文子
        第63 回 日本細胞生物学会大会、札幌、2011 年6 月 27-29 日( ポスター), Jun. 2011, Peer-reviewed
      • Genome-wide survey of kinases identified ABL 1 as a novel regulator of spindle orientation \nin adherent cells and mammalian skin.
        S. Matsumura; M. Hamasaki; T. Yamamoto; M. Ebisuya; M. Sato; E. Nishida; F. Toyoshima
        EMBO Conference “Centrosomes and Spindle Pole Bodies", October 2-6, 2011, Barcelona, Spain (oral), 2011, Peer-reviewed
      • Comaprison of human iPSCs generated from different \ntissues of identical donors．
        Nasu A; Kato T; Yamamoto T; Nakamura T; Toguchida J
        第33 回日本分子生物学会年会（2010.12.10 神戸）, 10 Dec. 2010, Peer-reviewed
      • The Dissection of Reprogramming Process in Murine Induced Pluripotent Stem Cells via Expression Patterns of Single-cells
        IWABUCHI KUMIKO A; ICHISAKA TOMOKO; YAMAMOTO TAKUYA; OKITA KEISUKE; YAMANAKA SHINYA
        生化学, 2010
      • 【細胞核の初期化メカニズム 多能性・全能性獲得のナゾに迫る】iPS細胞の樹立からみた「遺伝子導入と核のリプログラミング」
        山本 拓也; 山中 伸弥
        Medical Bio, Sep. 2009
      • 【幹細胞研究の最近の進歩 多能性幹細胞】幹細胞の多分化性/シグナル 未分化維持のシグナル MAPキナーゼシグナル伝達経路と多能性幹細胞
        山本 拓也; 西田 栄介
        最新医学, Mar. 2009
      • c-Abl チロシンキナーゼ による細胞分裂軸の制御機構
        松村繁; 濱畸眞弓; 戎家美紀; 山本拓也; 西田栄介; 豊島文子
        第32 回日本分子生物学会年会、横浜、2009年12月9-12 日, 2009, Peer-reviewed
      • c-Abl チロシンキナーゼ によるマウス胎杼の皮膚基底層における細胞分裂軸の制御機構
        松村繁; 濱畸眞弓; 戎家美紀; 山本拓也; 西田栄介; 豊島文子
        第82 回日本生化学会大会、神戸、2009 年10月21-24 日, 2009, Peer-reviewed
      • 【蛋白質の修飾と機能制御】MAPキナーゼERKの時空間制御
        山本 拓也; 西田 栄介
        蛋白質・核酸・酵素, Jun. 2007
      • 【シグナル伝達研究2005-'06 生命現象や疾患を支配する分子メカニズムと新しい研究法 現在と未来】シグナル伝達の主要因子・経路 MAPキナーゼカスケードの多様な役割
        山本 拓也; 西田 栄介
        実験医学, Jun. 2005
      • MAPキナーゼカスケードの多様な役割
        山本拓也; 西田栄介
        実験医学増刊号, Jun. 2005, Invited
      • The role of ERK MAP kinase in the G0/G1 to S phase transition
        Miki Ebisuya; Takuya Yamamoto; Eisuke Nishida
        CELL STRUCTURE AND FUNCTION, May 2004
      • 【臨床遺伝子学'03 がんのジェネティクス】増殖因子からがんへ
        山本 拓也; 西田 栄介
        最新医学, Sep. 2003

      Presentations

      • Dynamic alteration in RNA splicing during somatic cell reprogramming
        YAMAMOTO Takuya
        Global COE Program “Education and Research Center for Stem Cell Medicine” Final Symposium,, 04 Dec. 2012, Invited
      • Reversion of somatic splicing during the reprogramming process
        YAMAMOTO Takuya
        CLS-iCeMS Joint Symposium, 21 Apr. 2012, Invited
      • 次世代シークエンサーを用いたiPS細胞研究
        山本 拓也
        第35回近畿肉腫研究会, 18 Dec. 2010, Invited
      • 次世代シーケンサーを用いたiPS細胞研究
        山本 拓也
        Japan Sequencing Forum 2010, 30 Sep. 2010, Invited
      • 次世代シークエンサーSOLiDを用いたiPS細胞研究
        山本 拓也
        第43回日本発生生物学会ランチョンセミナー, 23 Jun. 2010, Invited
      • 次世代シークエンサーを用いたiPS細胞研究
        山本 拓也
        第57回日本生化学会近畿支部例会, 22 May 2010, Invited

      External funds: Kakenhi

      • RNA regulome in pluripotent stem cells
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        Takuya Yamamoto
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        RNA２次構造;多能性幹細胞;翻訳制御;RNA2次構造;転写後修飾;RNA制御
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03418/
      • 多能性幹細胞におけるＲＮＡ２次構造およびタンパク質翻訳調整機構の解明
        Grant-in-Aid for JSPS Fellows
        Basic Section 48040:Medical biochemistry-related
        Kyoto University
        山本 拓也
        From 25 Apr. 2019, To 31 Mar. 2021, Project Closed
        多能性幹細胞;RNA2次構造;翻訳制御
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19F19112/
      • 細胞分化可塑性を規定する染色体高次構造の解析
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        山本 拓也
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        ゲノム;発生・分化;発生･分化
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01352/
      • The roles of endogenous retrotransposition in somatic cell reprogramming
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Takuya Yamamoto
        From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
        ゲノム;発生・分化;発生･分化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670137/
      • Development of the evaluation method for individual iPS cells
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Takuya YAMAMOTO
        From 01 Apr. 2010, To 31 Mar. 2012, Project Closed
        再生医学;再生医療;遺伝子発現;多能性幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790287/
      • Molecular mechanisms underlying nuclear reprogramming of somatic cells
        Grant-in-Aid for Specially Promoted Research
        Biological Sciences
        Kyoto University
        Shinya YAMANAKA
        From 01 Apr. 2007, To 31 Mar. 2012, Project Closed
        再生医学;幹細胞;分化多能性;核初期化;転写因子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19002014/
      • 最長寿・発がん耐性齧歯類ハダカデバネズミ特異的制御遺伝子群の機能の解明
        Grant-in-Aid for Challenging Research (Pioneering)
        Medium-sized Section 42:Veterinary medical science, animal science, and related fields
        Kumamoto University
        三浦 恭子
        From 30 Jun. 2022, To 31 Mar. 2025, Granted
        ハダカデバネズミ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K18355/
      • ヒト胸腺発生の理解に向けたiPS細胞と胎児組織の統合トランスクリプトーム解析
        Fund for the Promotion of Joint International Research (International Collaborative Research)
        Medium-sized Section 48:Biomedical structure and function and related fields
        Kyoto University
        濱崎 洋子
        From 08 Sep. 2023, To 31 Mar. 2026, Granted
        胸腺;iPS細胞;再生;発生;単一細胞トランスクリプトーム解析
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23KK0136/
      • Analses of the formation of oxygen exchange niche through endothelial-epithelial interaction
        Grant-in-Aid for Scientific Research (B)
        Basic Section 44040:Morphology and anatomical structure-related
        National Cardiovascular Center Research Institute
        中嶋 洋行
        From 01 Apr. 2024, To 31 Mar. 2028, Granted
        血管内皮細胞;生体イメージング;ガス交換組織;上皮細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02057/
      • ハダカデバネズミの「健康長寿」システムを構成する分子基盤の解明
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 42:Veterinary medical science, animal science, and related fields
        Kumamoto University
        三浦 恭子
        From 01 Apr. 2024, To 31 Mar. 2027, Granted
        ハダカデバネズミ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00542/
      list
        Last Updated :2025/06/20

        Education

        Teaching subject(s)

        • From 01 Apr. 2025, To 31 Mar. 2026
          Advanced Course of Genome Life Science
          M216, Spring, Institute for Liberal Arts and Sciences, 1
        • From 01 Apr. 2025, To 31 Mar. 2026
          Advanced course of genome life sciences
          1038, Year-long, Graduate School of Biostudies, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Course of Genome Life Science
          M216, Spring, Institute for Liberal Arts and Sciences, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced course of genome life sciences
          1038, Year-long, Graduate School of Biostudies, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced course of genome life sciences
          1038, Year-long, Graduate School of Biostudies, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced Course of Genome Life Science
          M216, Spring, Institute for Liberal Arts and Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Course of Genome Life Science
          M216, Spring, Institute for Liberal Arts and Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced course of genome life sciences
          1038, Year-long, Graduate School of Biostudies, 1
        • From Apr. 2012, To Mar. 2013
          Integrated Cell-Material Sciences
          Fall, 全学共通科目
        • From Apr. 2013, To Mar. 2014
          Integrated Cell-Material Sciences
          Fall, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Integrated Cell-Material Sciences
          Fall, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Integrated Cell-Material Sciences
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Advanced course of genome life sciences
          Year-long, 生命科学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced course of genome life sciences
          Year-long, 生命科学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced course of genome life sciences
          Year-long, 生命科学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced course of genome life sciences
          Year-long, 生命科学研究科
        list
          Last Updated :2025/06/20

          Administration

          Faculty management (title, position)

          • From 01 Jun. 2011
            運営小委員会A（高速シークエンサー委員会）
          • From 01 Apr. 2020, To 31 Mar. 2026
            共通機器管理運営委員会3号委員
          • From 01 Apr. 2014, To 31 Mar. 2026
            情報管理委員会
          • From 01 Apr. 2019, To 31 Mar. 2021
            倫理審査委員会1号委員
          • From 01 Apr. 2020, To 31 Mar. 2026
            財務委員会2号委員
          • From 23 Jan. 2020, To 31 Mar. 2027
            動物実験施設運営委員会

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