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Ogawa, Haruo

Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical Sciences Associate Professor

Ogawa, Haruo
list
    Last Updated :2022/05/14

    Basic Information

    Faculty

    • 薬学部

    Academic Degree

    • 博士(理学)(東京工業大学)
    • 修士(理学)(東京工業大学)

    Research History

    • From Apr. 2021, To Present
      Kyoto University, Graduate School of Pharmaceutical Sciences, Associate Professor
    • From Apr. 2018, To Mar. 2021
      The University of Tokyo, Institute for Quantitative Biosciences, Laboratory of Protein Expression and Production, Associate Professor
    • From Jul. 2010, To Mar. 2018
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, Associate Professor
    • From Apr. 2009, To Jun. 2010
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, Associate Professor
    • From Jun. 2007, To Mar. 2009
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, 准教授
    • From Apr. 2007, To May 2007
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, 博士研究員
    • From Jul. 2004, To Mar. 2007
      University of Nevada, Reno, Department of Biochemistry and Molecular Biology, Reserch Assistant Professor
    • From Jan. 2002, To Jun. 2004
      Cleveland Clinif Foundation, Lerner Research Institute, Molecular Cardiology, Research fellow
    • From Jul. 1999, To Dec. 2001
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, 助手
    • From Apr. 1997, To Jun. 1999
      東京大学大学院, 医学系研究科, 助手

    Language of Instruction

    • Japanese

    ID,URL

    researchmap URL

    list
      Last Updated :2022/05/14

      Research

      Research Interests

      • membrane receptor
      • ion channel
      • ion pump
      • Structural biology

      Research Areas

      • Life sciences, Structural biochemistry

      Papers

      • Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations.
        Kobayashi T., Tsutsumi A., Kurebayashi N., Saito K., Kodama M., Sakurai T., Kikkawa M., Murayama T., Ogawa H.
        Nature Comm., 2022, Peer-reviewed, Corresponding author
      • Structure-based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy.
        Inoue Y., Yamaguchi T., Otsuka T., Utsunomiya Y., Pan D., Ogawa H., Kato H.
        Protein Sci, 2022, Peer-reviewed
      • Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors.
        Yui Kuroda; Miki Nonaka; Yuji Kamikubo; Haruo Ogawa; Takashi Murayama; Nagomi Kurebayashi; Hakushun Sakairi; Kanako Miyano; Akane Komatsu; Tetsushi Dodo; Kyoko Nakano-Ito; Keisuke Yamaguchi; Takashi Sakurai; Masako Iseki; Masakazu Hayashida; Yasuhito Uezono
        Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Sep. 2021
      • Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state.
        Ryuta Kanai; Flemming Cornelius; Haruo Ogawa; Kanna Motoyama; Bente Vilsen; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 07 Jan. 2021
      • What ATP binding does to the Ca2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2.
        Yoshiki Kabashima; Haruo Ogawa; Rie Nakajima; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 04 Aug. 2020, Peer-reviewed
      • Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.
        Haruo Ogawa; Nagomi Kurebayashi; Toshiko Yamazawa; Takashi Murayama
        Journal of muscle research and cell motility, 10 Feb. 2020, Peer-reviewed
      • Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics.
        Toshiko Yamazawa; Haruo Ogawa; Takashi Murayama; Maki Yamaguchi; Hideto Oyamada; Junji Suzuki; Nagomi Kurebayashi; Kazunori Kanemaru; Katsuji Oguchi; Takashi Sakurai; Masamitsu Iino
        The Journal of general physiology, 06 Jan. 2020, Peer-reviewed
      • Mechanism of the E2 to E1 transition in Ca2+ pump revealed by crystal structures of gating residue mutants.
        Naoki Tsunekawa; Haruo Ogawa; Junko Tsueda; Toshihiko Akiba; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 11 Dec. 2018, Peer-reviewed
      • Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels.
        Takashi Murayama; Nagomi Kurebayashi; Mari Ishigami-Yuasa; Shuichi Mori; Yukina Suzuki; Ryunosuke Akima; Haruo Ogawa; Junji Suzuki; Kazunori Kanemaru; Hideto Oyamada; Yuji Kiuchi; Masamitsu Iino; Hiroyuki Kagechika; Takashi Sakurai
        Molecular pharmacology, Jul. 2018, Peer-reviewed
      • Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.
        Eisuke Sato; Maho Morita; Haruo Ogawa; Masato Iwatsuki; Rei Hokari; Aki Ishiyama; Satoshi Ōmura; Arihiro Iwasaki; Kiyotake Suenaga
        Bioorganic & medicinal chemistry letters, 01 Feb. 2018, Peer-reviewed
      • A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity.
        Takashi Murayama; Haruo Ogawa; Nagomi Kurebayashi; Seiko Ohno; Minoru Horie; Takashi Sakurai
        Communications biology, 2018, Peer-reviewed
      • Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel.
        Takashi Murayama; Nagomi Kurebayashi; Haruo Ogawa; Toshiko Yamazawa; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Katsuji Oguchi; Masamitsu Iino; Takashi Sakurai
        Human mutation, Nov. 2016, Peer-reviewed
      • Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.
        Yimeng Zhao; Haruo Ogawa; Shin-Ichiro Yonekura; Hiroaki Mitsuhashi; Satomi Mitsuhashi; Ichizo Nishino; Chikashi Toyoshima; Shoichi Ishiura
        Biochimica et biophysica acta, Oct. 2015, Peer-reviewed
      • Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
        Haruo Ogawa; Flemming Cornelius; Ayami Hirata; Chikashi Toyoshima
        Nature communications, 10 Aug. 2015, Peer-reviewed
      • Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding.
        Maho Morita; Haruo Ogawa; Osamu Ohno; Takao Yamori; Kiyotake Suenaga; Chikashi Toyoshima
        FEBS letters, 04 Jun. 2015, Peer-reviewed
      • Stimulation, inhibition, or stabilization of Na,K-ATPase caused by specific lipid interactions at distinct sites.
        Michael Habeck; Haim Haviv; Adriana Katz; Einat Kapri-Pardes; Sophie Ayciriex; Andrej Shevchenko; Haruo Ogawa; Chikashi Toyoshima; Steven J D Karlish
        The Journal of biological chemistry, 20 Feb. 2015, Peer-reviewed
      • 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
        Hiroki Takai; Koji Masuda; Tomohiro Sato; Yuriko Sakaguchi; Takeo Suzuki; Tsutomu Suzuki; Ryo Koyama-Nasu; Yukiko Nasu-Nishimura; Yuki Katou; Haruo Ogawa; Yasuyuki Morishita; Hiroko Kozuka-Hata; Masaaki Oyama; Tomoki Todo; Yasushi Ino; Akitake Mukasa; Nobuhito Saito; Chikashi Toyoshima; Katsuhiko Shirahige; Tetsu Akiyama
        Cell reports, 09 Oct. 2014, Peer-reviewed
      • Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.
        Ryuta Kanai; Haruo Ogawa; Bente Vilsen; Flemming Cornelius; Chikashi Toyoshima
        Nature, 10 Oct. 2013, Peer-reviewed
      • Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.
        Chikashi Toyoshima; Shiho Iwasawa; Haruo Ogawa; Ayami Hirata; Junko Tsueda; Giuseppe Inesi
        Nature, 14 Mar. 2013, Peer-reviewed
      • Transmembrane topology and oligomeric structure of the high-affinity choline transporter.
        Takashi Okuda; Chieko Osawa; Haruhiko Yamada; Kengo Hayashi; Shizue Nishikawa; Tomoko Ushio; Yuji Kubo; Motoyasu Satou; Haruo Ogawa; Tatsuya Haga
        The Journal of biological chemistry, 14 Dec. 2012, Peer-reviewed
      • A new method for establishing stable cell lines and its use for large-scale production of human guanylyl cyclase-B receptor and of the extracellular domain.
        Naoki Okamoto; Haruo Ogawa; Chikashi Toyoshima
        Biochemical and biophysical research communications, 21 Sep. 2012, Peer-reviewed
      • Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase.
        Kunio S Misono; John S Philo; Tsutomu Arakawa; Craig M Ogata; Yue Qiu; Haruo Ogawa; Howard S Young
        The FEBS journal, Jun. 2011, Peer-reviewed
      • Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: possible allosteric regulation and a conserved structural motif for the chloride-binding site.
        Haruo Ogawa; Yue Qiu; John S Philo; Tsutomu Arakawa; Craig M Ogata; Kunio S Misono
        Protein science : a publication of the Protein Society, Mar. 2010, Peer-reviewed
      • Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain.
        Haruo Ogawa; Takehiro Shinoda; Flemming Cornelius; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 18 Aug. 2009, Peer-reviewed
      • Crystal structure of the sodium-potassium pump at 2.4 A resolution.
        Takehiro Shinoda; Haruo Ogawa; Flemming Cornelius; Chikashi Toyoshima
        Nature, 21 May 2009, Peer-reviewed
      • Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy.
        Haruo Ogawa; Yue Qiu; Liming Huang; Suk-Wah Tam-Chang; Howard S Young; Kunio S Misono
        The FEBS journal, Mar. 2009, Peer-reviewed
      • How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump.
        Chikashi Toyoshima; Yoshiyuki Norimatsu; Shiho Iwasawa; Takeo Tsuda; Haruo Ogawa
        Proceedings of the National Academy of Sciences of the United States of America, 11 Dec. 2007, Peer-reviewed
      • [ANP receptor structure and signal transduction mechanism: a novel hormone-induced rotation mechanism for transmembrane signaling].
        Kunio Misono; Haruo Ogawa; Yue Qiu; Craig M Ogata
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2005, Peer-reviewed
      • Structural studies of the natriuretic peptide receptor: a novel hormone-induced rotation mechanism for transmembrane signal transduction.
        Kunio S Misono; Haruo Ogawa; Yue Qiu; Craig M Ogata
        Peptides, Jun. 2005, Peer-reviewed
      • Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction.
        Haruo Ogawa; Yue Qiu; Craig M Ogata; Kunio S Misono
        The Journal of biological chemistry, 02 Jul. 2004, Peer-reviewed
      • The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump.
        Shinji Asano; Ayumi Yoshida; Hiroaki Yashiro; Yusuke Kobayashi; Anna Morisato; Haruo Ogawa; Noriaki Takeguchi; Magotoshi Morii
        The Journal of biological chemistry, 02 Apr. 2004, Peer-reviewed
      • Constitutive activation and uncoupling of the atrial natriuretic peptide receptor by mutations at the dimer interface. Role of the dimer structure in signalling.
        Yue Qiu; Haruo Ogawa; Masaru Miyagi; Kunio S Misono
        The Journal of biological chemistry, 13 Feb. 2004, Peer-reviewed
      • Crystallization and preliminary X-ray analysis of the atrial natriuretic peptide (ANP) receptor extracellular domain complex with ANP: use of ammonium sulfate as the cryosalt.
        Haruo Ogawa; Xiaolun Zhang; Yue Qiu; Craig M Ogata; Kunio S Misono
        Acta crystallographica. Section D, Biological crystallography, Oct. 2003, Peer-reviewed
      • Homology modeling of the cation binding sites of Na+K+-ATPase.
        Haruo Ogawa; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 10 Dec. 2002, Peer-reviewed
      • Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution
        Chikashi Toyoshima; Masayoshi Nakasako; Hiromi Nomura; Haruo Ogawa
        Nature, Jun. 2000
      • Soluble P-type ATPase from an archaeon,Methanococcus jannaschii
        Haruo Ogawa; Tatsuya Haga; Chikashi Toyoshima
        FEBS Letters, 07 Apr. 2000
      • GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin
        Kazuko Haga; Haruo Ogawa; Tatsuya Haga; Hiromu Murofushi
        European Journal of Biochemistry, 15 Jul. 1998
      • Structure of the Ca2+ Pump of Sarcoplasmic Reticulum: A View along the Lipid Bilayer at 9-Å Resolution
        Haruo Ogawa; David L. Stokes; Hiroyuki Sasabe; Chikashi Toyoshima
        Biophysical Journal, Jul. 1998
      • Lamellar stacking in three-dimensional crystals of Ca(2+)-ATPase from sarcoplasmic reticulum
        G.W. Cheong; H.S. Young; H. Ogawa; C. Toyoshima; D.L. Stokes
        Biophysical Journal, Apr. 1996

      Misc.

      • Structure Determination of Calcium Pump of Sarcoplasmic Reticulum
        TOYOSHIMA Chikashi; NAKASAKO Masayoshi; NOMURA Hiromi; OGAWA Haruo
        放射光, 30 Jun. 2001

      External funds: Kakenhi

      • GCase受容体の構造生物学ーリガンドの認識機構と結合シグナルの分子内伝達機構
        Grant-in-Aid for Scientific Research (C)
        Basic Section 43020:Structural biochemistry-related
        Juntendo University
        児玉 昌美
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        GCase受容体
      • Structural analysis of the gating mechanism of cardiac ryanodine receptor
        Grant-in-Aid for Scientific Research (B)
        Basic Section 43020:Structural biochemistry-related
        Kyoto University
        小川 治夫
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        膜蛋白質;リアノジン受容体;カルシウムチャネル;イオンチャネル;クライオ電子顕微鏡
      • 生理実験と分子動力学計算を組み合わせた新規リアノジン受容体制御機構の解析
        Grant-in-Aid for Scientific Research (C)
        Basic Section 48020:Physiology-related
        Jikei University School of Medicine
        山澤 徳志子
        From 01 Apr. 2019, To 31 Mar. 2022, Granted
        リアノジン受容体;リアノジン;カルシウム;分子動力学計算
      • 新規リアノジン受容体作用薬を利用したサブタイプ特異的チャネル制御の分子機構
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48020:Physiology-related
        Juntendo University
        村山 尚
        From 01 Apr. 2019, To 31 Mar. 2022, Granted
        リアノジン受容体;カルシウムチャネル;筋小胞体;構造解析;創薬;サブタイプ;機能解析;カルシウムイオン;イオンチャネル;骨格筋;興奮収縮連関;クライオ電子顕微鏡
      • Elucidation of tissue-specific calcium ion regulation mechanism by calcium pump by crystallography
        Grant-in-Aid for Scientific Research (B)
        The University of Tokyo
        Haruo Ogawa
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        膜蛋白質;イオンポンプ蛋白質;X線結晶解析;イオンポンプタンパク質;X線結晶構造解析
      • Structural elucidation of active transport by P-type ATPases
        Grant-in-Aid for Scientific Research (A)
        The University of Tokyo
        Chikashi Toyoshima
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        イオンポンプ;膜蛋白質;結晶解析;エネルギー変換;構造生物学;蛋白質;生物物理
      • Establishment of an over-expression system for mammalian large membrane proteins
        Grant-in-Aid for Challenging Exploratory Research
        The University of Tokyo
        Haruo Ogawa
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        大量発現;膜蛋白質;アデノウィルス;超巨大蛋白質
      • Structural analysis of PLN/SERCA regulatome toward understanding of the mechanism of Ca2+-regulation in the cardiac muscle cells
        Grant-in-Aid for Scientific Research (B)
        The University of Tokyo
        Haruo Ogawa
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        膜蛋白質;イオンポンプ蛋白質;X線結晶解析;X線結晶構造解析
      • PLN/SERCA2aレギュラトームによる心収縮調節機構の解明
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        The University of Tokyo
        小川 治夫
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        膜蛋白質;イオンポンプ蛋白質;心収縮
      • Structural biology of membrane transporters with a view to drug development
        Grant-in-Aid for Specially Promoted Research
        Biological Sciences
        The University of Tokyo
        Chikashi TOYOSHIMA
        From 31 May 2011, To 31 Mar. 2016, Project Closed
        イオンポンプ;膜蛋白質;結晶解析;エネルギー変換;エネルギー交換
      • Structure and functional analysis of the GCase receptor by x-ray
        Grant-in-Aid for Scientific Research (C)
        The University of Tokyo
        Haruo OGAWA
        From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
        受容体;ANP;ホルモン;膜受容体;膜蛋白質;X線結晶構造解析;X線結晶解析;大量発現
      • Structural biology of ion transporters
        Grant-in-Aid for Specially Promoted Research
        Biological Sciences
        The University of Tokyo
        Chikashi TOYOSHIMA
        Project Closed
        イオンポンプ;膜蛋白質;結晶解析
      • イオン能動輸送のメカニズム解明へ向けた立体構造解析
        Grant-in-Aid for Young Scientists (B)
        The University of Tokyo
        小川 治夫
        Project Closed
        P-type ATPase;ion pump;active transport;x-ray crystallography
      • Crystallographics study of active ion transport
        Grant-in-Aid for Scientific Research (A)
        The University of Tokyo
        Chikashi TOYOSHIMA
        Project Closed
        能動輸送;蛋白質結晶;膜蛋白質;イオンポンプ;電子線結晶解析;X線結晶解析;ATPase, active transport;Protein crystals;membrane proteins;ion pump;electron crystallography;X-ray crystallography;ATPase
      • Ca-ATPaseの電子線・X線結晶解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The University of Tokyo
        豊島 近
        Project Closed
        能動輸送;蛋白質結晶;膜蛋白質;イオンポンプ;X線結晶解析;ATPase;脂質二重膜;電子線結晶解析
      • ムスカリン性アセチルコリン受容体の2次元結晶化
        Grant-in-Aid for Encouragement of Young Scientists (A)
        The University of Tokyo
        小川 治夫
        Project Closed
        アセチルコリン受容体;二次元結晶;界面活性剤;SF9;バキュロウィルス
      • Structural Basis of Active Transport by Ion Pumps
        Grant-in-Aid for international Scientific Research
        The University of Tokyo
        Chikashi TOYOSHIMA
        Project Closed
        イオンポンプ;カルシウムポンプ;能動輸送;三次元構造;電子顕微鏡;構造解析;膜蛋白質, ion pump;calcium pump;active transport;three-dimensional structure;electron microscopy;structural analysis;membrane proteins
      list
        Last Updated :2022/05/14

        Administration

        Faculty management (title, position)

        • From 01 Apr. 2021, To 31 Mar. 2022
          教務委員会 委員
        • From 01 Apr. 2021, To 31 Mar. 2022
          図書委員会 委員
        • From 01 Apr. 2021, To 31 Mar. 2022
          建物・設備・機器管理運営委員会 委員

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