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Ogawa, Haruo

Graduate School of Pharmaceutical Sciences, Division of Pharmaceutical Sciences Associate Professor

Ogawa, Haruo
list
    Last Updated :2025/05/30

    Basic Information

    Faculty

    • 薬学部

    Academic Degree

    • 博士(理学)(東京工業大学)
    • 修士(理学)(東京工業大学)

    Research History

    • From Apr. 2021, To Present
      Kyoto University, Graduate School of Pharmaceutical Sciences, Associate Professor
    • From Apr. 2018, To Mar. 2021
      The University of Tokyo, Institute for Quantitative Biosciences, Laboratory of Protein Expression and Production, Associate Professor
    • From Jul. 2010, To Mar. 2018
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, Associate Professor
    • From Apr. 2009, To Jun. 2010
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, Associate Professor
    • From Jun. 2007, To Mar. 2009
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, 准教授
    • From Apr. 2007, To May 2007
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, 博士研究員
    • From Jul. 2004, To Mar. 2007
      University of Nevada, Reno, Department of Biochemistry and Molecular Biology, Reserch Assistant Professor
    • From Jan. 2002, To Jun. 2004
      Cleveland Clinif Foundation, Lerner Research Institute, Molecular Cardiology, Research fellow
    • From Jul. 1999, To Dec. 2001
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, 助手
    • From Apr. 1997, To Jun. 1999
      東京大学大学院, 医学系研究科, 助手

    Language of Instruction

    • Japanese

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/30

      Research

      Research Interests

      • membrane receptor
      • ion channel
      • ion pump
      • Structural biology

      Research Areas

      • Life sciences, Structural biochemistry

      Papers

      • Structural insight into hormone recognition and transmembrane signaling by the atrial natriuretic peptide receptor
        Haruo Ogawa; Masami Kodama; Kei Izumikawa
        10 Jul. 2020
      • Dual role of the S5 segment in type 1 ryanodine receptor channel gating
        Takashi Murayama; Yuya Otori; Nagomi Kurebayashi; Toshiko Yamazawa; Hideto Oyamada; Takashi Sakurai; Haruo Ogawa
        Communications Biology, 18 Sep. 2024, Peer-reviewed, Last author, Corresponding author
      • De Novo Missense Variations of ATP8B2 Impair Its Phosphatidylcholine Flippase Activity
        Hiroyuki Takatsu; Narumi Nishimura; Yusuke Kosugi; Haruo Ogawa; Kazuhisa Nakayama; Estelle Colin; Konrad Platzer; Rami Abou Jamra; Silke Redler; Clément Prouteau; Alban Ziegler; Hye-Won Shin
        Molecular and Cellular Biology, 02 Sep. 2024
      • 1P114 Rotational mechanism for transmembrane signaling by the atrial natriuretic peptide receptor(Membrane proteins,Poster Presentations)
        Ogawa Haruo; Qiu Yue; Ogata Craig M.; Misono Kunio
        Seibutsu Butsuri, 2007
      • Structural insight into hormone recognition by the natriuretic peptide receptor‐A
        Haruo Ogawa; Masami Kodama
        The FEBS Journal, 04 Mar. 2024, Peer-reviewed, Lead author, Corresponding author
      • Specific phospholipid binding to Na,K-ATPase at two distinct sites
        Michael Habeck; Einat Kapri-Pardes; Michal Sharon; Steven J. D. Karlish
        Proceedings of the National Academy of Sciences, 14 Mar. 2017
      • Structure–ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1
        Sorachi Miwa; Hiroshi Takikawa; Rina Takeuchi; Ryo Mizunuma; Keita Matsuoka; Haruo Ogawa; Hiroaki Kato; Kiyosei Takasu
        ACS Medicinal Chemistry Letters, 19 Jan. 2024, Peer-reviewed
      • Crystal Structure Analysis of Calcium Pump from Sarcoplasmic Reticulum.
        NAKASAKO Masayoshi; NOMURA Hiromi; OGAWA Haruo; TOYOSHIMA Chikashi
        X-RAYS, 31 Dec. 2000
      • Protein Crystallograpy using Electron Microscopy
        OGAWA Haruo; TOYOSHIMA Chikashi
        X-RAYS, 28 Feb. 1996
      • Homology modelling of the cation binding sites of the Na^+/K^+-ATPase 2
        Ogawa H.; Toyoshima C.
        Seibutsu Butsuri, 2001
      • Expression and characterization of new type of P-type ATPase.
        Ogawa H.; Haga T.; Toyoshima C.
        Seibutsu Butsuri, 1999
      • Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation.
        Hideki Itoh; Takashi Murayama; Nagomi Kurebayashi; Seiko Ohno; Takuya Kobayashi; Yusuke Fujii; Masaya Watanabe; Haruo Ogawa; Toshihisa Anzai; Minoru Horie
        Journal of electrocardiology, 07 Oct. 2021
      • Molecular basis for gating of cardiac ryanodine receptor: underlying mechanisms for gain- and loss-of function mutations
        Takuya Kobayashi; Akihisa Tsutsumi; Nagomi Kurebayashi; Kei Saito; Masami Kodama; Takashi Sakurai; Masahide Kikkawa; Takashi Murayama; Haruo Ogawa
        Nature Communications, 30 Nov. 2020, Peer-reviewed, Last author, Corresponding author
      • Structure‐based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy
        Yoshiki Inoue; Tomohiro Yamaguchi; Tetsuo Otsuka; Yuto Utsunomiya; Dongqing Pan; Haruo Ogawa; Hiroaki Kato
        Protein Science, Jun. 2022, Peer-reviewed
      • Inhibition of endothelin A receptor by a novel, selective receptor antagonist enhances morphine-induced analgesia: Possible functional interaction of dimerized endothelin A and μ-opioid receptors.
        Yui Kuroda; Miki Nonaka; Yuji Kamikubo; Haruo Ogawa; Takashi Murayama; Nagomi Kurebayashi; Hakushun Sakairi; Kanako Miyano; Akane Komatsu; Tetsushi Dodo; Kyoko Nakano-Ito; Keisuke Yamaguchi; Takashi Sakurai; Masako Iseki; Masakazu Hayashida; Yasuhito Uezono
        Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, Sep. 2021
      • Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state.
        Ryuta Kanai; Flemming Cornelius; Haruo Ogawa; Kanna Motoyama; Bente Vilsen; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 07 Jan. 2021
      • What ATP binding does to the Ca2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2.
        Yoshiki Kabashima; Haruo Ogawa; Rie Nakajima; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 04 Aug. 2020, Peer-reviewed
      • Regulatory mechanisms of ryanodine receptor/Ca2+ release channel revealed by recent advancements in structural studies.
        Haruo Ogawa; Nagomi Kurebayashi; Toshiko Yamazawa; Takashi Murayama
        Journal of muscle research and cell motility, 10 Feb. 2020, Peer-reviewed
      • Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics.
        Toshiko Yamazawa; Haruo Ogawa; Takashi Murayama; Maki Yamaguchi; Hideto Oyamada; Junji Suzuki; Nagomi Kurebayashi; Kazunori Kanemaru; Katsuji Oguchi; Takashi Sakurai; Masamitsu Iino
        The Journal of general physiology, 06 Jan. 2020, Peer-reviewed
      • Mechanism of the E2 to E1 transition in Ca2+ pump revealed by crystal structures of gating residue mutants.
        Naoki Tsunekawa; Haruo Ogawa; Junko Tsueda; Toshihiko Akiba; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 11 Dec. 2018, Peer-reviewed
      • Efficient High-Throughput Screening by Endoplasmic Reticulum Ca2+ Measurement to Identify Inhibitors of Ryanodine Receptor Ca2+-Release Channels.
        Takashi Murayama; Nagomi Kurebayashi; Mari Ishigami-Yuasa; Shuichi Mori; Yukina Suzuki; Ryunosuke Akima; Haruo Ogawa; Junji Suzuki; Kazunori Kanemaru; Hideto Oyamada; Yuji Kiuchi; Masamitsu Iino; Hiroyuki Kagechika; Takashi Sakurai
        Molecular pharmacology, Jul. 2018, Peer-reviewed
      • Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.
        Eisuke Sato; Maho Morita; Haruo Ogawa; Masato Iwatsuki; Rei Hokari; Aki Ishiyama; Satoshi Ōmura; Arihiro Iwasaki; Kiyotake Suenaga
        Bioorganic & medicinal chemistry letters, 01 Feb. 2018, Peer-reviewed
      • A tryptophan residue in the caffeine-binding site of the ryanodine receptor regulates Ca2+ sensitivity.
        Takashi Murayama; Haruo Ogawa; Nagomi Kurebayashi; Seiko Ohno; Minoru Horie; Takashi Sakurai
        Communications biology, 2018, Peer-reviewed
      • Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel.
        Takashi Murayama; Nagomi Kurebayashi; Haruo Ogawa; Toshiko Yamazawa; Hideto Oyamada; Junji Suzuki; Kazunori Kanemaru; Katsuji Oguchi; Masamitsu Iino; Takashi Sakurai
        Human mutation, Nov. 2016, Peer-reviewed
      • Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle.
        Yimeng Zhao; Haruo Ogawa; Shin-Ichiro Yonekura; Hiroaki Mitsuhashi; Satomi Mitsuhashi; Ichizo Nishino; Chikashi Toyoshima; Shoichi Ishiura
        Biochimica et biophysica acta, Oct. 2015, Peer-reviewed
      • Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
        Haruo Ogawa; Flemming Cornelius; Ayami Hirata; Chikashi Toyoshima
        Nature communications, 10 Aug. 2015, Peer-reviewed
      • Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca(2+) pumps with a unique mode of binding.
        Maho Morita; Haruo Ogawa; Osamu Ohno; Takao Yamori; Kiyotake Suenaga; Chikashi Toyoshima
        FEBS letters, 04 Jun. 2015, Peer-reviewed
      • Stimulation, inhibition, or stabilization of Na,K-ATPase caused by specific lipid interactions at distinct sites.
        Michael Habeck; Haim Haviv; Adriana Katz; Einat Kapri-Pardes; Sophie Ayciriex; Andrej Shevchenko; Haruo Ogawa; Chikashi Toyoshima; Steven J D Karlish
        The Journal of biological chemistry, 20 Feb. 2015, Peer-reviewed
      • 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.
        Hiroki Takai; Koji Masuda; Tomohiro Sato; Yuriko Sakaguchi; Takeo Suzuki; Tsutomu Suzuki; Ryo Koyama-Nasu; Yukiko Nasu-Nishimura; Yuki Katou; Haruo Ogawa; Yasuyuki Morishita; Hiroko Kozuka-Hata; Masaaki Oyama; Tomoki Todo; Yasushi Ino; Akitake Mukasa; Nobuhito Saito; Chikashi Toyoshima; Katsuhiko Shirahige; Tetsu Akiyama
        Cell reports, 09 Oct. 2014, Peer-reviewed
      • Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state.
        Ryuta Kanai; Haruo Ogawa; Bente Vilsen; Flemming Cornelius; Chikashi Toyoshima
        Nature, 10 Oct. 2013, Peer-reviewed
      • Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.
        Chikashi Toyoshima; Shiho Iwasawa; Haruo Ogawa; Ayami Hirata; Junko Tsueda; Giuseppe Inesi
        Nature, 14 Mar. 2013, Peer-reviewed
      • Transmembrane topology and oligomeric structure of the high-affinity choline transporter.
        Takashi Okuda; Chieko Osawa; Haruhiko Yamada; Kengo Hayashi; Shizue Nishikawa; Tomoko Ushio; Yuji Kubo; Motoyasu Satou; Haruo Ogawa; Tatsuya Haga
        The Journal of biological chemistry, 14 Dec. 2012, Peer-reviewed
      • A new method for establishing stable cell lines and its use for large-scale production of human guanylyl cyclase-B receptor and of the extracellular domain.
        Naoki Okamoto; Haruo Ogawa; Chikashi Toyoshima
        Biochemical and biophysical research communications, 21 Sep. 2012, Peer-reviewed
      • Structure, signaling mechanism and regulation of the natriuretic peptide receptor guanylate cyclase.
        Kunio S Misono; John S Philo; Tsutomu Arakawa; Craig M Ogata; Yue Qiu; Haruo Ogawa; Howard S Young
        The FEBS journal, Jun. 2011, Peer-reviewed
      • Reversibly bound chloride in the atrial natriuretic peptide receptor hormone-binding domain: possible allosteric regulation and a conserved structural motif for the chloride-binding site.
        Haruo Ogawa; Yue Qiu; John S Philo; Tsutomu Arakawa; Craig M Ogata; Kunio S Misono
        Protein science : a publication of the Protein Society, Mar. 2010, Peer-reviewed
      • Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain.
        Haruo Ogawa; Takehiro Shinoda; Flemming Cornelius; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 18 Aug. 2009, Peer-reviewed
      • Crystal structure of the sodium-potassium pump at 2.4 A resolution.
        Takehiro Shinoda; Haruo Ogawa; Flemming Cornelius; Chikashi Toyoshima
        Nature, 21 May 2009, Peer-reviewed
      • Structure of the atrial natriuretic peptide receptor extracellular domain in the unbound and hormone-bound states by single-particle electron microscopy.
        Haruo Ogawa; Yue Qiu; Liming Huang; Suk-Wah Tam-Chang; Howard S Young; Kunio S Misono
        The FEBS journal, Mar. 2009, Peer-reviewed
      • How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump.
        Chikashi Toyoshima; Yoshiyuki Norimatsu; Shiho Iwasawa; Takeo Tsuda; Haruo Ogawa
        Proceedings of the National Academy of Sciences of the United States of America, 11 Dec. 2007, Peer-reviewed
      • [ANP receptor structure and signal transduction mechanism: a novel hormone-induced rotation mechanism for transmembrane signaling].
        Kunio Misono; Haruo Ogawa; Yue Qiu; Craig M Ogata
        Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2005, Peer-reviewed
      • Structural studies of the natriuretic peptide receptor: a novel hormone-induced rotation mechanism for transmembrane signal transduction.
        Kunio S Misono; Haruo Ogawa; Yue Qiu; Craig M Ogata
        Peptides, Jun. 2005, Peer-reviewed
      • Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction.
        Haruo Ogawa; Yue Qiu; Craig M Ogata; Kunio S Misono
        The Journal of biological chemistry, 02 Jul. 2004, Peer-reviewed
      • The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump.
        Shinji Asano; Ayumi Yoshida; Hiroaki Yashiro; Yusuke Kobayashi; Anna Morisato; Haruo Ogawa; Noriaki Takeguchi; Magotoshi Morii
        The Journal of biological chemistry, 02 Apr. 2004, Peer-reviewed
      • Constitutive activation and uncoupling of the atrial natriuretic peptide receptor by mutations at the dimer interface. Role of the dimer structure in signalling.
        Yue Qiu; Haruo Ogawa; Masaru Miyagi; Kunio S Misono
        The Journal of biological chemistry, 13 Feb. 2004, Peer-reviewed
      • Crystallization and preliminary X-ray analysis of the atrial natriuretic peptide (ANP) receptor extracellular domain complex with ANP: use of ammonium sulfate as the cryosalt.
        Haruo Ogawa; Xiaolun Zhang; Yue Qiu; Craig M Ogata; Kunio S Misono
        Acta crystallographica. Section D, Biological crystallography, Oct. 2003, Peer-reviewed
      • Homology modeling of the cation binding sites of Na+K+-ATPase.
        Haruo Ogawa; Chikashi Toyoshima
        Proceedings of the National Academy of Sciences of the United States of America, 10 Dec. 2002, Peer-reviewed
      • Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution
        Chikashi Toyoshima; Masayoshi Nakasako; Hiromi Nomura; Haruo Ogawa
        Nature, Jun. 2000
      • Soluble P‐type ATPase from an archaeon, Methanococcus jannaschii
        Haruo Ogawa; Tatsuya Haga; Chikashi Toyoshima
        FEBS Letters, 07 Apr. 2000
      • GTP‐binding‐protein‐coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin
        Kazuko Haga; Haruo Ogawa; Tatsuya Haga; Hiromu Murofushi
        European Journal of Biochemistry, 15 Jul. 1998
      • Structure of the Ca2+ Pump of Sarcoplasmic Reticulum: A View along the Lipid Bilayer at 9-Å Resolution
        Haruo Ogawa; David L. Stokes; Hiroyuki Sasabe; Chikashi Toyoshima
        Biophysical Journal, Jul. 1998
      • Lamellar stacking in three-dimensional crystals of Ca(2+)-ATPase from sarcoplasmic reticulum
        G.W. Cheong; H.S. Young; H. Ogawa; C. Toyoshima; D.L. Stokes
        Biophysical Journal, Apr. 1996

      Misc.

      • Structural basis for the effect of caffeine on RyR2 analyzed by cryo-EM
        大鳥祐矢; BURTON-SMITH Raymond; 呉林なごみ; 村田和義; 加藤博章; 加藤博章; 村山尚; 小川治夫
        日本生体エネルギー研究会討論会講演要旨集, 2023
      • RyR2caffeine複合体の構造解析-caffeineはどのように効能を引き起こすのか?
        大鳥祐矢; BURTON-SMITH Raymond; 呉林なごみ; 村田和義; 加藤博章; 加藤博章; 村山尚; 小川治夫
        日本生化学会大会(Web), 2023
      • Multidrug-recognition mechanism of ABC transporter by X-ray crystallography
        水沼諒; 小田島圭; 三和空知; 瀧川紘; 高須清誠; 小川治夫; 加藤博章; 加藤博章
        日本薬学会年会要旨集(Web), 2023
      • LARGE-SCALE CHROMATOGRAPHIC PURIFICATION OF H^+-PYROPHOSPHATASE AND ITS STABILIZING METHODS :
        MIMURA Hisatoshi; TOYOSHIMA Chikashi; OGAWA Haruo; NOMURA Hiromi; MAESHIMA Masayoshi
        Plant and cell physiology, 2001
      • Single-Molecule Twisting Motions During Gating of the Human TRPV1 Channel Recorded with Sub-Millisecond Time Resolution
        Hirofumi Shimizu; Takuya Kobayashi; Masayuki Iwamoto; Kentaro Kajiwara; Nagomi Kurebayashi; Haruo Ogawa; Takashi Murayama
        BIOPHYSICAL JOURNAL, Feb. 2020
      • Genotype-Phenotype Correlations of the Central Core Disease Mutations in the C-Terminal Region of the RyR1 Channel
        Takashi Murayama; Nagomi Kurebayashi; Haruo Ogawa; Toshiko Yamazawa; Takashi Sakurai
        BIOPHYSICAL JOURNAL, Feb. 2017
      • 小胞体内Ca2+濃度測定を利用した新規RyR1阻害薬のハイスループットスクリーニング
        村山 尚; 呉林 なごみ; 湯浅 磨里; 石上; 森 修一; 鈴木 志奈; 秋間 龍之介; 小川 治夫; 鈴木 純二; 金丸 和典; 小山田 英人; 木内 祐二; 飯野 正光; 影近 弘之; 櫻井 隆
        日本筋学会学術集会プログラム・抄録集, Aug. 2018
      • S4-S5 Linker Regulates RyR2 Channel Gating through Multiple Interactions
        Takashi Murayama; Nagomi Kurebayashi; Haruo Ogawa; Junji Suzuki; Kazunori Kanemam; Masamitsu Iino; Takashi Sakurai
        BIOPHYSICAL JOURNAL, Feb. 2016
      • Large production of mammalian membrane proteins toward determination of high-resolution structure
        H. Ogawa; C. Toyoshima
        EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Jul. 2017
      • Large Scale Production of Mammalian Membrane Proteins Toward Determination of High-Resolution Structure
        Haruo Ogawa; Chikashi Toyoshima
        BIOPHYSICAL JOURNAL, Feb. 2017
      • Kinetics by X-Ray Crystallography: Sequential Substitution of K+ Bound To Na+, K+-ATPase
        Haruo Ogawa; Flemming Cornelius; Ayami Hirata; Chikashi Toyoshima
        BIOPHYSICAL JOURNAL, Feb. 2016
      • X-Ray Crystallographic Study of Na,K-ATPase in Complex with Cardiotonic Steroids
        Haruo Ogawa; Kanna Motoyama; Flemming Cornelius; Bente Vilsen; Chikashi Toyoshima
        BIOPHYSICAL JOURNAL, Jan. 2015
      • STRUCTURAL ASPECTS OF CATION PUMPING BY P-TYPE ATPASES
        Chikashi Toyoshima; Takehiro Shinoda; Haruo Ogawa; Flemming Cornelius
        JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009
      • Electron and X-ray crystallography of the 3D crystals of Ca^<2+> ATPase
        TOYOSHIMA C.; OGAWA H.; TANI K.; NOMURA H.; NAKASAKO M.
        Biophysics, Oct. 1997
      • Structural study of 3D micro crystal of Ca2+-ATPase using frozen hydrated microscopy
        H Ogawa; C Toyoshima
        PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1996
      • Molecular Dynamics and Ca2+ Imaging of Mutant Type 1 Ryanodine Receptor
        Toshiko Yamazawa; Haruo Ogawa; Takashi Murayama; Maki Yamaguchi; Hideto Oyamada; Junji Suzuki; Nagomi Kurebayashi; Kanemaru Kazunori; Takashi Sakurai; Masamitsu Iino
        BIOPHYSICAL JOURNAL, Feb. 2020
      • Investigation of Mutant Ryanodine Receptor Channel Activity using Functional Analysis and Molecular Dynamics
        Toshiko Yamazawa; Haruo Ogawa; Maki Yamaguchi; Takashi Murayama; Hideto Oyamada; Junji Suzuki; Nagomi Kurebayashi; Kazunori Kanemaru; Takashi Sakurai; Iino Masamitsu
        BIOPHYSICAL JOURNAL, Feb. 2019
      • 膜蛋白質の構造解析
        小川 治夫; 豊島 近
        ファルマシア, 01 Jan. 1999
      • Structure Determination of Calcium Pump of Sarcoplasmic Reticulum
        TOYOSHIMA Chikashi; NAKASAKO Masayoshi; NOMURA Hiromi; OGAWA Haruo
        放射光, 30 Jun. 2001

      External funds: Kakenhi

      • Structural biology of GC-A receptor - Mechanism underlying peptide recognition and intramolecular signal transduction
        Grant-in-Aid for Scientific Research (C)
        Basic Section 43020:Structural biochemistry-related
        University of Shizuoka;Juntendo University
        Masami Kodama
        From 01 Apr. 2021, To 31 Mar. 2024, Project Closed
        GC受容体;ナトリウム利尿ペプチド;グアニル酸シクラーゼ受容体;GCase受容体
      • Structural analysis of the gating mechanism of cardiac ryanodine receptor
        Grant-in-Aid for Scientific Research (B)
        Basic Section 43020:Structural biochemistry-related
        Kyoto University
        小川 治夫
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        膜蛋白質;リアノジン受容体;カルシウムチャネル;イオンチャネル;クライオ電子顕微鏡;構造解析
      • Analysis of a novel ryanodine receptor modulation mechanism using physiological experiments and molecular dynamics calculations
        Grant-in-Aid for Scientific Research (C)
        Basic Section 48020:Physiology-related
        Jikei University School of Medicine
        Toshio Yamazawa
        From 01 Apr. 2019, To 31 Mar. 2023, Project Closed
        リアノジン受容体;Ca2+放出;悪性高熱症;カルシウム;骨格筋;熱;リアノジン;分子動力学計算
      • Molecular basis of subtype-specific channel regulation using novel ryanodine receptor modulators
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48020:Physiology-related
        Juntendo University
        Takashi Murayama
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        リアノジン受容体;カルシウムチャネル;興奮収縮連関;小胞体;サブタイプ;骨格筋;悪性高熱症;筋小胞体;構造解析;創薬;機能解析;カルシウムイオン;イオンチャネル;クライオ電子顕微鏡
      • Elucidation of tissue-specific calcium ion regulation mechanism by calcium pump by crystallography
        Grant-in-Aid for Scientific Research (B)
        The University of Tokyo
        Haruo Ogawa
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        膜蛋白質;イオンポンプ蛋白質;X線結晶解析;イオンポンプタンパク質;X線結晶構造解析
      • Structural elucidation of active transport by P-type ATPases
        Grant-in-Aid for Scientific Research (A)
        The University of Tokyo
        Chikashi Toyoshima
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        イオンポンプ;膜蛋白質;結晶解析;エネルギー変換;構造生物学;蛋白質;生物物理
      • Establishment of an over-expression system for mammalian large membrane proteins
        Grant-in-Aid for Challenging Exploratory Research
        The University of Tokyo
        Haruo Ogawa
        From 01 Apr. 2013, To 31 Mar. 2017, Project Closed
        大量発現;膜蛋白質;アデノウィルス;超巨大蛋白質
      • Structural analysis of PLN/SERCA regulatome toward understanding of the mechanism of Ca2+-regulation in the cardiac muscle cells
        Grant-in-Aid for Scientific Research (B)
        The University of Tokyo
        Haruo Ogawa
        From 01 Apr. 2013, To 31 Mar. 2017, Project Closed
        膜蛋白質;イオンポンプ蛋白質;X線結晶解析;X線結晶構造解析
      • PLN/SERCA2aレギュラトームによる心収縮調節機構の解明
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        The University of Tokyo
        小川 治夫
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        膜蛋白質;イオンポンプ蛋白質;心収縮
      • Structural biology of membrane transporters with a view to drug development
        Grant-in-Aid for Specially Promoted Research
        Biological Sciences
        The University of Tokyo
        Chikashi TOYOSHIMA
        From 01 Apr. 2011, To 31 Mar. 2017, Project Closed
        イオンポンプ;膜蛋白質;結晶解析;エネルギー変換;エネルギー交換
      • Structure and functional analysis of the GCase receptor by x-ray
        Grant-in-Aid for Scientific Research (C)
        The University of Tokyo
        Haruo OGAWA
        From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
        受容体;ANP;ホルモン;膜受容体;膜蛋白質;X線結晶構造解析;X線結晶解析;大量発現
      • Structural biology of ion transporters
        Grant-in-Aid for Specially Promoted Research
        Biological Sciences
        The University of Tokyo
        Chikashi TOYOSHIMA
        From 01 Apr. 2007, To 31 Mar. 2012, Project Closed
        イオンポンプ;膜蛋白質;結晶解析
      • イオン能動輸送のメカニズム解明へ向けた立体構造解析
        Grant-in-Aid for Young Scientists (B)
        The University of Tokyo
        小川 治夫
        From 01 Apr. 2001, To 31 Mar. 2003, Project Closed
        P-type ATPase;ion pump;active transport;x-ray crystallography
      • Crystallographics study of active ion transport
        Grant-in-Aid for Scientific Research (A)
        The University of Tokyo
        Chikashi TOYOSHIMA
        From 01 Apr. 1999, To 31 Mar. 2002, Project Closed
        能動輸送;蛋白質結晶;膜蛋白質;イオンポンプ;電子線結晶解析;X線結晶解析;ATPase, active transport;Protein crystals;membrane proteins;ion pump;electron crystallography;X-ray crystallography;ATPase
      • Ca-ATPaseの電子線・X線結晶解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The University of Tokyo
        豊島 近
        From 01 Apr. 1999, To 31 Mar. 2003, Project Closed
        能動輸送;蛋白質結晶;膜蛋白質;イオンポンプ;X線結晶解析;ATPase;脂質二重膜;電子線結晶解析
      • ムスカリン性アセチルコリン受容体の2次元結晶化
        Grant-in-Aid for Encouragement of Young Scientists (A)
        The University of Tokyo
        小川 治夫
        From 01 Apr. 1998, To 31 Mar. 2001, Project Closed
        アセチルコリン受容体;二次元結晶;界面活性剤;SF9;バキュロウィルス
      • Structural Basis of Active Transport by Ion Pumps
        Grant-in-Aid for international Scientific Research
        The University of Tokyo
        Chikashi TOYOSHIMA
        From 01 Apr. 1996, To 31 Mar. 1998, Project Closed
        イオンポンプ;カルシウムポンプ;能動輸送;三次元構造;電子顕微鏡;構造解析;膜蛋白質, ion pump;calcium pump;active transport;three-dimensional structure;electron microscopy;structural analysis;membrane proteins
      • Development of RyR2-specific inhibitors and activators and their application as antiarrhythmic agents
        Grant-in-Aid for Scientific Research (C)
        Basic Section 47040:Pharmacology-related
        Juntendo University
        呉林 なごみ
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        2型リアノジン受容体;不整脈;抗不整脈薬;カルシウム;機能抑制型変異;心筋;創薬
      • Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48020:Physiology-related
        Juntendo University
        村山 尚
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        リアノジン受容体;カルシウムイオン;骨格筋;興奮収縮連関;カルシウム遊離チャネル
      • 膜1回貫通型受容体を対象にした「構造生物学での最後のフロンティア」解消への挑戦
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 47:Pharmaceutical sciences and related fields
        Kyoto University
        小川 治夫
        From 30 Jun. 2022, To 31 Mar. 2025, Granted
        膜タンパク質;立体構造解析;膜1回貫通型受容体;クライオ電子顕微鏡
      • X線1分子動態計測による膜蛋白質マルチセンシング機構の動的解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48020:Physiology-related
        University of Fukui
        清水 啓史
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        1分子計測;蛋白質;X線回折
      • Molecular basis and physiological significance of O-mannosyl glycans in mammals
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
        Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
        萬谷 博
        From 01 Apr. 2023, To 31 Mar. 2028, Granted
        糖鎖;筋疾患;神経疾患;O-マンノース型糖鎖;糖転移酵素
      • 創薬へ向けた心筋型リアノジン受容体の活性制御機構の構造的解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
        Kyoto University
        小川 治夫
        From 01 Apr. 2024, To 31 Mar. 2027, Granted
        リアノジン受容体
      • Structural basis of diversed and dynamic substrate recognition mechanism of multidrug transporter by chemical trapping
        Grant-in-Aid for Scientific Research (B)
        Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
        Kyoto University
        加藤 博章
        From 01 Apr. 2024, To 31 Mar. 2027, Granted
        分子認識;輸送体;クライオ電子顕微鏡;構造生物学;構造薬理学
      • X線1分子動態計測による膜蛋白質マルチセンシング機構の動的解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48020:Physiology-related
        University of Fukui
        清水 啓史
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        1分子計測;蛋白質;X線回折
      • Molecular basis and physiological significance of O-mannosyl glycans in mammals
        Grant-in-Aid for Scientific Research (B)
        Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
        Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
        萬谷 博
        From 01 Apr. 2023, To 31 Mar. 2028, Granted
        糖鎖;筋疾患;神経疾患;O-マンノース型糖鎖;糖転移酵素
      • Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
        Grant-in-Aid for Scientific Research (B)
        Basic Section 48020:Physiology-related
        Juntendo University
        村山 尚
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        リアノジン受容体;カルシウムチャネル;興奮収縮連関;筋収縮;カルシウムイオン;骨格筋;筋小胞体;カルシウム遊離チャネル

      External funds: others

      • 哺乳類細胞発現系を用いた創薬関連高難度ヒト膜タンパク質の生産から結晶化へ向けたワンストップ支援とその高度化 (2021年度分)
        文部科学省, 医療研究開発推進事業費補助金
        From 01 Apr. 2021, To 31 Mar. 2022
        代表
      list
        Last Updated :2025/05/30

        Education

        Teaching subject(s)

        • From 01 Apr. 2025, To 31 Mar. 2026
          Pharmaceutical Laboratory I : Analytical and Physical Chemistry
          C901, Spring, Faculty of Pharmaceutical Sciences, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Basic Informatics (Faculty of Pharmaceutical Sciences)
          T012, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)
          T005, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Physical Chemistry for Drug Discovery B
          8202, Spring, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Laboratory Practice in Basic Analytical Chemistry and Structural Biology
          4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Introduction to Physical Chemistry for Drug Discovery
          8101, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Introduction to Physical Chemistry for Drug Discovery
          1217, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Basic Physical Chemistry II
          1212, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Basic Physical Chemistry I
          1211, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Pharmaceutical Sciences II
          6006, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Introduction to Pharmaceutical Sciences
          6002, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Seminar in Basic Biophysical Chemistry
          2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Basic Laboratory Techniques in Physical Chemistry
          1206, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Basic Laboratory Techniques in Physical Chemistry
          1206, Fall, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Physical Chemistry 4 (Biophysical Chemistry)
          A104, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Physical Chemistry 3 (Structural Chemistry)
          A103, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Physical Chemistry IV (Biophysical Chemistry)
          C104, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Physical Chemistry III (Structural Chemistry)
          C103, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Pharmaceutical Laboratory I : Analytical and Physical Chemistry
          C901, Spring, Faculty of Pharmaceutical Sciences, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Research in Basic Biophysical Chemistry
          3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2023, To 31 Mar. 2024
          Basic Informatics (Faculty of Pharmaceutical Sciences)
          T012, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)
          T005, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced Physical Chemistry for Drug Discovery B
          8202, Spring, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Laboratory Practice in Basic Analytical Chemistry and Structural Biology
          4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Pharmaceutical Laboratory I : Analytical and Physical Chemistry
          C901, Spring, Faculty of Pharmaceutical Sciences, 3
        • From 01 Apr. 2023, To 31 Mar. 2024
          Research in Basic Biophysical Chemistry
          3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2023, To 31 Mar. 2024
          Pharmaceutical Laboratory 1 : Analytical and Physical Chemistry
          A901, Spring, Faculty of Pharmaceutical Sciences, 4
        • From 01 Apr. 2023, To 31 Mar. 2024
          Physical Chemistry III (Structural Chemistry)
          C103, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Physical Chemistry 4 (Biophysical Chemistry)
          A104, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Physical Chemistry 3 (Structural Chemistry)
          A103, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Physical Chemistry IV (Biophysical Chemistry)
          C104, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Basic Laboratory Techniques in Physical Chemistry
          1206, Fall, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Basic Laboratory Techniques in Physical Chemistry
          1206, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Seminar in Basic Biophysical Chemistry
          2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Introduction to Physical Chemistry for Drug Discovery
          1217, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced Basic Physical Chemistry II
          1212, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Introduction to Physical Chemistry for Drug Discovery
          8101, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced Pharmaceutical Sciences II
          6006, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Introduction to Pharmaceutical Sciences
          6002, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory I : Analytical and Physical Chemistry
          C901, Spring, Faculty of Pharmaceutical Sciences, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Physical Chemistry 4 (Biophysical Chemistry)
          A104, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Physical Chemistry III (Structural Chemistry)
          C103, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Physical Chemistry for Drug Discovery
          8101, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Practice of Basic Informatics (Faculty of Pharmaceutical Sciences)
          T005, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar in Basic Biophysical Chemistry
          2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Physical Chemistry IV (Biophysical Chemistry)
          C104, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Informatics (Faculty of Pharmaceutical Sciences)
          T012, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Physical Chemistry 3 (Structural Chemistry)
          A103, Fall, Faculty of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Pharmaceutical Laboratory 1 : Analytical and Physical Chemistry
          A901, Spring, Faculty of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Laboratory Practice in Basic Analytical Chemistry and Structural Biology
          4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Research in Basic Biophysical Chemistry
          3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Laboratory Techniques in Physical Chemistry
          1206, Spring, Graduate School of Pharmaceutical Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Introduction to Physical Chemistry for Drug Discovery
          1217, Spring, Graduate School of Pharmaceutical Sciences, 2
        list
          Last Updated :2025/05/30

          Administration

          School management (title, position)

          • From 01 Apr. 2024, To 31 Mar. 2026
            国際高等教育院 企画評価専門委員会 物理学部会 委員
          • From 01 Apr. 2023, To 31 Mar. 2024
            国際高等教育院 企画評価専門委員会 人文・社会科学部会2 委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            国際高等教育院 企画評価専門委員会 人文・社会科学部会2 委員

          Faculty management (title, position)

          • From 01 Apr. 2024, To 31 Mar. 2025
            実験動物施設運営委員会 委員
          • From 01 Apr. 2023, To 31 Mar. 2025
            環境・安全衛生委員会 委員
          • From 01 Apr. 2024, To 31 Mar. 2025
            情報セキュリティ委員会 委員
          • From 01 Apr. 2022, To 31 Mar. 2025
            情報システム委員会 委員
          • From 01 Apr. 2022, To 31 Mar. 2025
            動物実験委員会 委員
          • From 01 Apr. 2021, To 31 Mar. 2025
            教務委員会 委員
          • From 01 Apr. 2021, To 31 Mar. 2025
            図書委員会 委員
          • From 01 Apr. 2021, To 31 May 2023
            建物・設備・機器管理運営委員会 委員

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