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Naruse, Chie

Graduate School of Medicine Associate Professor

Naruse, Chie
list
    Last Updated :2022/11/23

    Basic Information

    Faculty

    • 医学部

    Professional Memberships

    • 日本分子生物学会
    • JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
    • JAPANESE ASSOCIATION FOR EXPERIMENTAL ANIMAL TECHNOLOGISTS
    • 日本エピジェネティクス研究会

    Academic Degree

    • 修士(理学)(東京大学)
    • 博士(理学)(東京大学)

    Research History

    • From Apr. 2018, To Present
      Kyoto University, Institute of Laboratory Animals, Graduate School of Medicine, 准教授
    • From Jan. 2015, To Mar. 2018
      Kyoto University, Institute of Laboratory Animals, Graduate School of Medicine, 助教
    • From Oct. 2003, To Dec. 2014
      Kanazawa University, Advanced Science Research Center, 助教
    • From 2001, To 2003
      : Kanazawa University
    • From 2003
      -: Kanazawa University

    Profile

    • Profile

      私たちの研究室では遺伝子配列だけでは一義的に決まらないタンパク質修飾が,疾患発症にどのように関わるのか,遺伝子改変マウスやラットを用いて解析しています。

      私は,脳神経系や発生過程の複雑な系におけるエピジェネティック制御の役割を解明するために,特に転写抑制性ヒストン修飾に注目しています。これまでに,ヒストンの特定のアミノ酸のメチル基を認識するヘテロクロマチンプロテイン1(HP1)や,特定のアミノ酸のメチル基を除去するJmjd3, Utxの遺伝子改変マウスを作製して,脳神経系や発生過程での解析を行い,生殖細胞の発生,神経幹細胞の維持,前後軸の正常な発生に関わることを見出してきました。

      また,研究室グループの一員として,β4-ガラクトース転移酵素(B4galt)遺伝子群やシアル酸合成酵素の機能解析に携わってきました。我々の研究グループでは,糖鎖合成酵素の変異がIgA腎症やネフローゼ症候群など,腎疾患の原因となること,B4galt1ノックアウトマウスの造血幹細胞がホーミングできないことなどを見出し,疾患モデルとしての研究も進めています。

    Language of Instruction

    • Japanese
    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2022/11/23

      Research

      Research Topics, Overview of the research

      • Research Topics

        Analyses of the functions of epigenetic factors and glycosylation in mammalian development.
      • Overview of the research

        We are trying to elucidate the molecular mechanisms of mammalian development using mice and rats. Specifically, using genetically modified mice and rats made by genome editing technology, we analyze phenotypes that appear when genes considered necessary for mammalian development are modified, and confirm the function of those genes. Based on these findings, we will develop disease and therapeutical model mice and rats that contribute to the development of therapeutics for human diseases.

      Research Interests

      • マウス
      • 糖鎖
      • 発生
      • エピジェネティクス
      • 疾患モデル動物

      Research Areas

      • Life sciences, Developmental biology
      • Life sciences, Laboratory animal science
      • Life sciences, Animals: biochemistry, physiology, behavioral science
      • Life sciences, Laboratory animal science

      Papers

      • A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice.
        Chie Naruse; Kazushi Sugihara; Tatsuhiko Miyazaki; Xuchi Pan; Fumihiro Sugiyama; Masahide Asano
        NAR cancer, Jun. 2022
      • Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.
        Mengnan Li; Shin-Ya Nishio; Chie Naruse; Meghan Riddell; Sabrina Sapski; Tatsuya Katsuno; Takao Hikita; Fatemeh Mizapourshafiyi; Fiona M Smith; Leanne T Cooper; Min Goo Lee; Masahide Asano; Thomas Boettger; Marcus Krueger; Astrid Wietelmann; Johannes Graumann; Bryan W Day; Andrew W Boyd; Stefan Offermanns; Shin-Ichiro Kitajiri; Shin-Ichi Usami; Masanori Nakayama
        Nature communications, 12 Mar. 2020, Peer-reviewed
      • Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes.
        Chie Naruse; Kanae Abe; Toru Yoshihara; Tomoaki Kato; Takumi Nishiuchi; Masahide Asano
        FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Mar. 2020, Peer-reviewed
      • Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow.
        Soichiro Takagaki; Rieko Yamashita; Noriyoshi Hashimoto; Kazushi Sugihara; Kanako Kanari; Keisuke Tabata; Toshikazu Nishie; Shogo Oka; Masanori Miyanishi; Chie Naruse; Masahide Asano
        Scientific reports, 09 May 2019, Peer-reviewed
      • Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice.
        Toru Yoshihara; Hiroyuki Satake; Toshikazu Nishie; Nozomu Okino; Toshihisa Hatta; Hiroki Otani; Chie Naruse; Hiroshi Suzuki; Kazushi Sugihara; Eikichi Kamimura; Noriyo Tokuda; Keiko Furukawa; Koichi Fururkawa; Makoto Ito; Masahide Asano
        PLoS genetics, Aug. 2018, Peer-reviewed
      • Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice
        Toru Yoshihara; Hiroyuki Satake; Toshikazu Nishie; Nozomu Okino; Toshihisa Hatta; Hiroki Otani; Chie Naruse; Hiroshi Suzuki; Kazushi Sugihara; Eikichi Kamimura; Noriyo Tokuda; Keiko Furukawa; Koichi Fururkawa; Makoto Ito; Masahide Asano
        PLoS Genetics, Aug. 2018, Peer-reviewed
      • New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice
        Chie Naruse; Shinwa Shibata; Masaru Tamura; Takayuki Kawaguchi; Kanae Abe; Kazushi Sugihara; Tomoaki Kato; Takumi Nishiuchi; Shigeharu Wakana; Masahito Ikawa; Masahide Asano
        FASEB JOURNAL, Jun. 2017, Peer-reviewed
      • Cbx3/HP1 gamma deficiency confers enhanced tumor-killing capacity on CD8(+) T cells
        Michael Sun; Ngoc Ha; Duc-Hung Pham; Megan Frederick; Bandana Sharma; Chie Naruse; Masahide Asano; Matthew E. Pipkin; Rani E. George; To-Ha Thai
        SCIENTIFIC REPORTS, Feb. 2017, Peer-reviewed
      • HP-1 gamma controls high-affinity antibody response to T-dependent antigens
        Ngoc Ha; Duc-Hung Pham; Aliakbar Shahsafaei; Chie Naruse; Masahide Asano; To-Ha Thai
        FRONTIERS IN IMMUNOLOGY, Jun. 2014, Peer-reviewed
      • A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells
        Rika Ohno; Megumi Nakayama; Chie Naruse; Naoki Okashita; Osamu Takano; Makoto Tachibana; Masahide Asano; Mitinori Saitou; Yoshiyuki Seki
        DEVELOPMENT, Jul. 2013, Peer-reviewed
      • Evidence that the EphA2 receptor exacerbates ischemic brain injury.
        John Thundyil; Silvia Manzanero; Dale Pavlovski; Tanya R Cully; Ker-Zhing Lok; Alexander Widiapradja; Prasad Chunduri; Dong-Gyu Jo; Chie Naruse; Masahide Asano; Bradley S Launikonis; Christopher G Sobey; Mark G Coulthard; Thiruma V Arumugam
        PloS one, 2013, Peer-reviewed
      • Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell Cycle Progression in Mice
        Kanae Abe; Chie Naruse; Tomoaki Kato; Takumi Nishiuchi; Mitinori Saitou; Masahide Asano
        BIOLOGY OF REPRODUCTION, Nov. 2011, Peer-reviewed
      • HP1 gamma links histone methylation marks to meiotic synapsis in mice
        Yuki Takada; Chie Naruse; Yael Costa; Takayuki Shirakawa; Makoto Tachibana; Jafar Sharif; Fuyuko Kezuka-Shiotani; Dai Kakiuchi; Hiroshi Masumoto; Yo-ichi Shinkai; Kazuyuki Ohbo; Antoine H. F. M. Peters; James M. A. Turner; Masahide Asano; Haruhiko Koseki
        DEVELOPMENT, Oct. 2011, Peer-reviewed
      • beta 4-Galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development
        Toshikazu Nishie; Yoko Hikimochi; Kota Zama; Yoshiyasu Fukusumi; Mitutoshi Ito; Haruka Yokoyama; Chie Naruse; Makoto Ito; Masahide Asano
        GLYCOBIOLOGY, Oct. 2010, Peer-reviewed
      • Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis
        Naoko Irie; Yasunari Takada; Yoshihiko Watanabe; Yumi Matsuzaki; Chie Naruse; Masahide Asano; Yoichiro Iwakura; Toshio Suda; Koichi Matsuo
        JOURNAL OF BIOLOGICAL CHEMISTRY, May 2009
      • EphA2 is an essential mediator of UV radiation-induced apoptosis
        Guoqi Zhang; Ching-Ni Njaw; Jong Min Park; Chie Naruse; Masahide Asano; Hensin Tsao
        CANCER RESEARCH, Mar. 2008
      • Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo
        Yoshiyasu Fukusumi; Chie Naruse; Masahide Asano
        DEVELOPMENTAL DYNAMICS, Mar. 2008
      • A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model
        Tomoya Kaneda; Chie Naruse; Atsuhiro Kawashima; Noboru Fujino; Toru Oshima; Masanobu Namura; Shinichi Nunoda; Sumio Mori; Tetsuo Konno; Hidekazu Ino; Masakazu Yamagishi; Masahide Asano
        CLINICAL SCIENCE, Mar. 2008
      • 学習・記憶の制御における糖鎖の役割
        浅野 雅秀; 吉原 亨; 杉原 一司; 木塚 康彦; 岡 昌吾; 成瀬 智恵; 阿部 可奈恵
        金沢大学十全医学会雑誌, Sep. 2007
      • A novel gene trapping for identifying genes expressed under the control of specific transcription factors
        Chie Naruse; Yoshiyasu Fukusumi; Dai Kakiuchi; Masahide Asano
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007
      • Development of immunoglobulin A nephropathy-like disease in beta-1,4-galactosyltransferase-I-deficient mice
        Toshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chile Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide Asano
        AMERICAN JOURNAL OF PATHOLOGY, Feb. 2007
      • Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in beta-1,4-galactosyltransferase-deficient mice
        Toshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chie Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide Asano
        IGA NEPHROPATHY TODAY, 2007
      • Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in beta-1,4-galactosyltransferase-deficient mice
        Toshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chie Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide Asano
        IGA NEPHROPATHY TODAY, 2007, Peer-reviewed
      • IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity
        S Nakae; C Naruse-Nakajima; K Sudo; R Horai; M Asano; Y Iwakura
        INTERNATIONAL IMMUNOLOGY, Dec. 2001
      • Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1
        C Naruse-Nakajima; M Asano; Y Iwakura
        MECHANISMS OF DEVELOPMENT, Apr. 2001

      Misc.

      • Analysis of EphA2 receptor tyrosine kinase disrupted mice by gene trap retroviral insertion
        NARUSE-NAKAJIMA Chie; ASANO Masahide; IWAKURA Yoichiro
        日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998
      • 遺伝子トラップ法
        生物工学会誌, 2003
      • IL-1 alpha but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity
        S Nakae; C Naruse-Nakajima; K Sudo; R Horai; M Asano; Y Iwakura
        JOURNAL OF LEUKOCYTE BIOLOGY, 2001

      Industrial Property Rights

      • ORC4遺伝子変異非ヒト動物

      External funds: Kakenhi

      • 時期および組織特異的なプロテインノックダウンを可能とするデグロンシステムの開発
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 42:Veterinary medical science, animal science, and related fields
        Kyoto University
        成瀬 智恵
        From 09 Jul. 2021, To 31 Mar. 2024, Granted
        デグロン;マウス;プロテインノックダウン
      • Analysis of galactose carbohydrates regulating homing and differentiation of HSC in the bone marrow niche
        Grant-in-Aid for Scientific Research (B)
        Basic Section 42040:Laboratory animal science-related
        Kyoto University
        浅野 雅秀
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        ガラクトース糖鎖;造血幹細胞;ホーミング;血液細胞分化;骨髄ニッチ
      • Development of degron system for cancer therapy
        Grant-in-Aid for Scientific Research (B)
        Basic Section 42040:Laboratory animal science-related
        Kyoto University
        成瀬 智恵
        From 01 Apr. 2020, To 31 Mar. 2024, Granted
        デグロン;マウス;PD-1;プロテインノックダウン
      • Establishment of a novel cancer therapy using degron system in mice
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 42:Veterinary medical science, animal science, and related fields
        Kyoto University
        Masahide Asano
        From 29 Jun. 2018, To 31 Mar. 2021, Project Closed
        デグロン;PD-1;マウス;がん免疫療法
      • Functions of B4galt1 in the homing of hematopoietic stem cells.
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Chie Naruse
        From 01 Apr. 2017, To 31 Mar. 2020, Project Closed
        造血幹細胞;ホーミング;糖鎖;マウス;B4galt1;造血幹細胞分化;β4GalT1;beta4-GalT1;GalT1;応用動物
      • Attempt to establish totipotent stem cells using degron system
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Kazushi Sugihara
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        デグロン;マウス;ゲノム編集;マウス初期胚発生;デグロンシステム;発生;初期胚;発生・分化;動物
      • Establishment of new mental disease model mouse by heterochromatin factor HP1 deficiency
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Toru Yoshihara
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        マウス;精神疾患モデル;行動解析;エピジェネティクス;モデルマウス;精神疾患;不安;うつ;情動性;活動性;行動薬理学的解析;薬理学的解析;発現アレイ解析;モデル動物
      • Study on neurological disorder caused by ganglioside-deficiency and therapeutics by glycolipid supplement
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Masahide Asano
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        ガングリオシド;LacCer合成酵素;ガラクトース転移酵素;神経細胞;軸索;ミエリン鞘;神経幹細胞;糖鎖;脳神経疾患
      • Analysis of gut microbiota and gut immunity in the development of IgA nephropathy using its mouse model
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        MASAHIDE ASANO
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        IgA腎症;糖鎖;腸内細菌叢;腸内細菌
      • The roles of histone modifications in the perinatal period.
        Grant-in-Aid for Scientific Research (C)
        Kyoto University;Kanazawa University
        Chie Naruse
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        マウス;脱メチル化酵素;ホメオティック変異;ヒストン脱メチル化;HP1;神経幹細胞;エピジェネティクス;発生;神経;Hox遺伝子
      • Analysis of brain functions regulated by histone modification and development of psychiatric disorder animal models
        Grant-in-Aid for Scientific Research (B)
        Kyoto University;Kanazawa University
        Masahide Asano
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        エピジェネティクス;脳神経疾患;行動学;遺伝子改変マウス;脳・神経;遺伝子組換えマウス
      • 生殖細胞の発生・分化においてヒストン修飾因子が果たす制御機構の解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kanazawa University
        浅野 雅秀
        From 01 Apr. 2011, To 31 Mar. 2013, Project Closed
        発生・分化;生殖細胞;始原生殖細胞;ヒストン修飾;遺伝子改変動物
      • Analyses of mutant mice lacking histone modification factors.
        Grant-in-Aid for Young Scientists (B)
        Kanazawa University
        Chie NARUSE
        From 01 Apr. 2010, To 31 Mar. 2012, Project Closed
        発生・分化;生殖細胞;マウス;ヒストン修飾;遺伝子改変動物;始原生殖細胞
      • 始原生殖細胞の初期分化におけるHP1γとヒストン修飾の機能解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kanazawa University
        浅野 雅秀
        From 01 Apr. 2009, To 31 Mar. 2011, Project Closed
        発生・分化;生殖細胞;始原生殖細胞;ヒストン修飾;遺伝子改変動物;始源生殖細胞;エピジェネティクス;細胞周期
      • Analyses of infertility of HP1γ mutant mice
        Grant-in-Aid for Young Scientists (B)
        Kanazawa University
        Chie NARUSE
        From 01 Apr. 2008, To 31 Mar. 2010, Project Closed
        HP1;マウス;生殖細胞;ヒストン修飾;エピジェネティクス;減数分裂
      • EphA2/EphA4変異マウスを用いた腎嚢胞性疾患発症の分子メカニズムの解明
        Grant-in-Aid for Young Scientists (B)
        Kanazawa University
        成瀬 智恵
        From 01 Apr. 2006, To 31 Mar. 2008, Project Closed
        EphA2;EphA4;ephrinA;MAPK;腎嚢胞性疾患;破骨細胞;腎臓形成;尿管芽形成
      • 生殖細胞のインプリンティングおよび減数分裂におけるHP1γの機能解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kanazawa University
        浅野 雅秀
        From 01 Apr. 2006, To 31 Mar. 2008, Project Closed
        生殖細胞;エピジェネティックス;インプリンティング;遺伝子改変マウス;不妊
      • β4-ガラクトース転移酵素-I欠損によるIga腎症発症機構の解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kanazawa University
        浅野 雅秀
        From 01 Apr. 2005, To 31 Mar. 2007, Project Closed
        IgA腎症;ガラクトース転移酵素;高IgA血症;遺伝子ノックアウトマウス
      • ORC4変異マウスを用いた個体レベルでの細胞周期研究
        Grant-in-Aid for Exploratory Research
        Kanazawa University
        浅野 雅秀
        From 01 Apr. 2003, To 31 Mar. 2005, Project Closed
        複製開始点認識複合体;Orc4;トランスジェニックマウス;胚性幹細胞;DNA複製;細胞周期;遺伝子トラップ
      list
        Last Updated :2022/11/23

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Laboratory Animal Science
          8030, Spring, Faculty of Medicine, 1
        • From Apr. 2018, To Mar. 2019
          Labolatory histo and cyto Pathology
          Spring, 医学部(人間健康科学科)
        • From Apr. 2019, To Mar. 2020
          Laboratory Animal Science
          Spring, 医学部(人間健康科学科)
        • From Apr. 2020, To Mar. 2021
          Laboratory Animal Science
          Spring, 医学部(人間健康科学科)
        • From Apr. 2021, To Mar. 2022
          Laboratory Animal Science
          Spring, 医学部(人間健康科学科)
        list
          Last Updated :2022/11/23

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2015, To 30 Sep. 2018
            動物実験委員会
          • From 01 Apr. 2015, To 31 Mar. 2019
            医学図書館図書連絡委員会
          • From 01 Apr. 2015, To 31 Mar. 2019
            動物実験施設運営委員会
          • From 01 Oct. 2020, To 30 Sep. 2022
            動物実験委員会委員
          list
            Last Updated :2022/11/23

            Academic, Social Contribution

            Committee Memberships

            • From Jul. 2020, To Present
              評議員, 日本実験動物学会
            • From Apr. 2018, To Present
              Experimental Animals編集委員, 日本実験動物学会

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