Search for faculty members
Naruse, Chie
Graduate School of Medicine Associate Professor
list
Last Updated :2024/09/18
Basic Information
Faculty
Professional Memberships
- 日本分子生物学会
- JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
- JAPANESE ASSOCIATION FOR EXPERIMENTAL ANIMAL TECHNOLOGISTS
- 日本エピジェネティクス研究会
Academic Degree
Research History
- From Apr. 2018, To PresentKyoto University, Institute of Laboratory Animals, Graduate School of Medicine, 准教授
- From Jan. 2015, To Mar. 2018Kyoto University, Institute of Laboratory Animals, Graduate School of Medicine, 助教
- From Oct. 2003, To Dec. 2014Kanazawa University, Advanced Science Research Center, 助教
- From 2001, To 2003: Kanazawa University
- From 2003-: Kanazawa University
Profile
Profile
私たちの研究室では遺伝子配列だけでは一義的に決まらないタンパク質修飾が，疾患発症にどのように関わるのか，遺伝子改変マウスやラットを用いて解析しています。
私は，脳神経系や発生過程の複雑な系におけるエピジェネティック制御の役割を解明するために，特に転写抑制性ヒストン修飾に注目しています。これまでに，ヒストンの特定のアミノ酸のメチル基を認識するヘテロクロマチンプロテイン1（HP1）や，特定のアミノ酸のメチル基を除去するJmjd3, Utxの遺伝子改変マウスを作製して，脳神経系や発生過程での解析を行い，生殖細胞の発生，神経幹細胞の維持，前後軸の正常な発生に関わることを見出してきました。
また，研究室グループの一員として，β4-ガラクトース転移酵素（B4galt）遺伝子群やシアル酸合成酵素の機能解析に携わってきました。我々の研究グループでは，糖鎖合成酵素の変異がIgA腎症やネフローゼ症候群など，腎疾患の原因となること，B4galt1ノックアウトマウスの造血幹細胞がホーミングできないことなどを見出し，疾患モデルとしての研究も進めています。
Language of Instruction
ID,URL
J-Global ID
External link
researchmap URL
list
Last Updated :2024/09/18
Research
Research Topics, Overview of the research
Research Topics
Analyses of the functions of epigenetic factors and glycosylation in mammalian development.Overview of the research
We are trying to elucidate the molecular mechanisms of mammalian development using mice and rats. Specifically, using genetically modified mice and rats made by genome editing technology, we analyze phenotypes that appear when genes considered necessary for mammalian development are modified, and confirm the function of those genes. Based on these findings, we will develop disease and therapeutical model mice and rats that contribute to the development of therapeutics for human diseases.
Research Interests
Research Areas
- Life sciences, Developmental biology
- Life sciences, Laboratory animal science
- Life sciences, Animals: biochemistry, physiology, behavioral science
Papers
- Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.Heng Wei; Chie Naruse; Daisuke Takakura; Kazushi Sugihara; Xuchi Pan; Aki Ikeda; Nana Kawasaki; Masahide AsanoFrontiers in immunology, 2023
- A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice.Chie Naruse; Kazushi Sugihara; Tatsuhiko Miyazaki; Xuchi Pan; Fumihiro Sugiyama; Masahide AsanoNAR cancer, Jun. 2022
- Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.Mengnan Li; Shin-Ya Nishio; Chie Naruse; Meghan Riddell; Sabrina Sapski; Tatsuya Katsuno; Takao Hikita; Fatemeh Mizapourshafiyi; Fiona M Smith; Leanne T Cooper; Min Goo Lee; Masahide Asano; Thomas Boettger; Marcus Krueger; Astrid Wietelmann; Johannes Graumann; Bryan W Day; Andrew W Boyd; Stefan Offermanns; Shin-Ichiro Kitajiri; Shin-Ichi Usami; Masanori NakayamaNature communications, 12 Mar. 2020, Peer-reviewed
- Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes.Chie Naruse; Kanae Abe; Toru Yoshihara; Tomoaki Kato; Takumi Nishiuchi; Masahide AsanoFASEB journal : official publication of the Federation of American Societies for Experimental Biology, Mar. 2020, Peer-reviewed
- Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow.Soichiro Takagaki; Rieko Yamashita; Noriyoshi Hashimoto; Kazushi Sugihara; Kanako Kanari; Keisuke Tabata; Toshikazu Nishie; Shogo Oka; Masanori Miyanishi; Chie Naruse; Masahide AsanoScientific reports, 09 May 2019, Peer-reviewed
- Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice.Toru Yoshihara; Hiroyuki Satake; Toshikazu Nishie; Nozomu Okino; Toshihisa Hatta; Hiroki Otani; Chie Naruse; Hiroshi Suzuki; Kazushi Sugihara; Eikichi Kamimura; Noriyo Tokuda; Keiko Furukawa; Koichi Fururkawa; Makoto Ito; Masahide AsanoPLoS genetics, Aug. 2018, Peer-reviewed
- Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in miceToru Yoshihara; Hiroyuki Satake; Toshikazu Nishie; Nozomu Okino; Toshihisa Hatta; Hiroki Otani; Chie Naruse; Hiroshi Suzuki; Kazushi Sugihara; Eikichi Kamimura; Noriyo Tokuda; Keiko Furukawa; Koichi Fururkawa; Makoto Ito; Masahide AsanoPLoS Genetics, Aug. 2018, Peer-reviewed
- New insights into the role of Jmjd3 and Utx in axial skeletal formation in miceChie Naruse; Shinwa Shibata; Masaru Tamura; Takayuki Kawaguchi; Kanae Abe; Kazushi Sugihara; Tomoaki Kato; Takumi Nishiuchi; Shigeharu Wakana; Masahito Ikawa; Masahide AsanoFASEB JOURNAL, Jun. 2017, Peer-reviewed
- Cbx3/HP1 gamma deficiency confers enhanced tumor-killing capacity on CD8(+) T cellsMichael Sun; Ngoc Ha; Duc-Hung Pham; Megan Frederick; Bandana Sharma; Chie Naruse; Masahide Asano; Matthew E. Pipkin; Rani E. George; To-Ha ThaiSCIENTIFIC REPORTS, Feb. 2017, Peer-reviewed
- HP-1 gamma controls high-affinity antibody response to T-dependent antigensNgoc Ha; Duc-Hung Pham; Aliakbar Shahsafaei; Chie Naruse; Masahide Asano; To-Ha ThaiFRONTIERS IN IMMUNOLOGY, Jun. 2014, Peer-reviewed
- A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cellsRika Ohno; Megumi Nakayama; Chie Naruse; Naoki Okashita; Osamu Takano; Makoto Tachibana; Masahide Asano; Mitinori Saitou; Yoshiyuki SekiDEVELOPMENT, Jul. 2013, Peer-reviewed
- Evidence that the EphA2 receptor exacerbates ischemic brain injury.John Thundyil; Silvia Manzanero; Dale Pavlovski; Tanya R Cully; Ker-Zhing Lok; Alexander Widiapradja; Prasad Chunduri; Dong-Gyu Jo; Chie Naruse; Masahide Asano; Bradley S Launikonis; Christopher G Sobey; Mark G Coulthard; Thiruma V ArumugamPloS one, 2013, Peer-reviewed
- Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell Cycle Progression in MiceKanae Abe; Chie Naruse; Tomoaki Kato; Takumi Nishiuchi; Mitinori Saitou; Masahide AsanoBIOLOGY OF REPRODUCTION, Nov. 2011, Peer-reviewed
- HP1 gamma links histone methylation marks to meiotic synapsis in miceYuki Takada; Chie Naruse; Yael Costa; Takayuki Shirakawa; Makoto Tachibana; Jafar Sharif; Fuyuko Kezuka-Shiotani; Dai Kakiuchi; Hiroshi Masumoto; Yo-ichi Shinkai; Kazuyuki Ohbo; Antoine H. F. M. Peters; James M. A. Turner; Masahide Asano; Haruhiko KosekiDEVELOPMENT, Oct. 2011, Peer-reviewed
- beta 4-Galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic developmentToshikazu Nishie; Yoko Hikimochi; Kota Zama; Yoshiyasu Fukusumi; Mitutoshi Ito; Haruka Yokoyama; Chie Naruse; Makoto Ito; Masahide AsanoGLYCOBIOLOGY, Oct. 2010, Peer-reviewed
- Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses OsteoblastogenesisNaoko Irie; Yasunari Takada; Yoshihiko Watanabe; Yumi Matsuzaki; Chie Naruse; Masahide Asano; Yoichiro Iwakura; Toshio Suda; Koichi MatsuoJOURNAL OF BIOLOGICAL CHEMISTRY, May 2009
- EphA2 is an essential mediator of UV radiation-induced apoptosisGuoqi Zhang; Ching-Ni Njaw; Jong Min Park; Chie Naruse; Masahide Asano; Hensin TsaoCANCER RESEARCH, Mar. 2008
- Wtap is required for differentiation of endoderm and mesoderm in the mouse embryoYoshiyasu Fukusumi; Chie Naruse; Masahide AsanoDEVELOPMENTAL DYNAMICS, Mar. 2008
- A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse modelTomoya Kaneda; Chie Naruse; Atsuhiro Kawashima; Noboru Fujino; Toru Oshima; Masanobu Namura; Shinichi Nunoda; Sumio Mori; Tetsuo Konno; Hidekazu Ino; Masakazu Yamagishi; Masahide AsanoCLINICAL SCIENCE, Mar. 2008
- 学習・記憶の制御における糖鎖の役割浅野 雅秀; 吉原 亨; 杉原 一司; 木塚 康彦; 岡 昌吾; 成瀬 智恵; 阿部 可奈恵金沢大学十全医学会雑誌, Sep. 2007
- A novel gene trapping for identifying genes expressed under the control of specific transcription factorsChie Naruse; Yoshiyasu Fukusumi; Dai Kakiuchi; Masahide AsanoBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007
- Development of immunoglobulin A nephropathy-like disease in beta-1,4-galactosyltransferase-I-deficient miceToshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chile Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide AsanoAMERICAN JOURNAL OF PATHOLOGY, Feb. 2007
- Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in beta-1,4-galactosyltransferase-deficient miceToshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chie Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide AsanoIGA NEPHROPATHY TODAY, 2007
- Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in beta-1,4-galactosyltransferase-deficient miceToshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chie Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide AsanoIGA NEPHROPATHY TODAY, 2007, Peer-reviewed
- IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivityS Nakae; C Naruse-Nakajima; K Sudo; R Horai; M Asano; Y IwakuraINTERNATIONAL IMMUNOLOGY, Dec. 2001
- Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1C Naruse-Nakajima; M Asano; Y IwakuraMECHANISMS OF DEVELOPMENT, Apr. 2001
Misc.
- Analysis of EphA2 receptor tyrosine kinase disrupted mice by gene trap retroviral insertionNARUSE-NAKAJIMA Chie; ASANO Masahide; IWAKURA Yoichiro日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998
- 遺伝子トラップ法生物工学会誌, 2003
- IL-1 alpha but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivityS Nakae; C Naruse-Nakajima; K Sudo; R Horai; M Asano; Y IwakuraJOURNAL OF LEUKOCYTE BIOLOGY, 2001
Industrial Property Rights
External funds: Kakenhi
- 時期および組織特異的なプロテインノックダウンを可能とするデグロンシステムの開発Grant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 42:Veterinary medical science, animal science, and related fieldsKyoto University成瀬 智恵From 09 Jul. 2021, To 31 Mar. 2024, Grantedデグロン;マウス;プロテインノックダウン
- Analysis of galactose carbohydrates regulating homing and differentiation of HSC in the bone marrow nicheGrant-in-Aid for Scientific Research (B)Basic Section 42040:Laboratory animal science-relatedKyoto University浅野 雅秀From 01 Apr. 2021, To 31 Mar. 2024, Grantedガラクトース糖鎖;造血幹細胞;ホーミング;血液細胞分化;骨髄ニッチ
- Development of degron system for cancer therapyGrant-in-Aid for Scientific Research (B)Basic Section 42040:Laboratory animal science-relatedKyoto University成瀬 智恵From 01 Apr. 2020, To 31 Mar. 2024, Grantedデグロン;マウス;プロテインノックダウン;PD-1
- Establishment of a novel cancer therapy using degron system in miceGrant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 42:Veterinary medical science, animal science, and related fieldsKyoto UniversityMasahide AsanoFrom 29 Jun. 2018, To 31 Mar. 2021, Project Closedデグロン;PD-1;マウス;がん免疫療法
- Functions of B4galt1 in the homing of hematopoietic stem cells.Grant-in-Aid for Scientific Research (C)Kyoto UniversityChie NaruseFrom 01 Apr. 2017, To 31 Mar. 2020, Project Closed造血幹細胞;ホーミング;糖鎖;マウス;B4galt1;造血幹細胞分化;β4GalT1;beta4-GalT1;GalT1;応用動物
- Attempt to establish totipotent stem cells using degron systemGrant-in-Aid for Challenging Exploratory ResearchKyoto UniversityKazushi SugiharaFrom 01 Apr. 2016, To 31 Mar. 2019, Project Closedデグロン;マウス;ゲノム編集;マウス初期胚発生;デグロンシステム;発生;初期胚;発生・分化;動物
- Establishment of new mental disease model mouse by heterochromatin factor HP1 deficiencyGrant-in-Aid for Scientific Research (C)Kyoto UniversityToru YoshiharaFrom 01 Apr. 2016, To 31 Mar. 2019, Project Closedマウス;精神疾患モデル;行動解析;エピジェネティクス;モデルマウス;精神疾患;不安;うつ;情動性;活動性;行動薬理学的解析;薬理学的解析;発現アレイ解析;モデル動物
- Study on neurological disorder caused by ganglioside-deficiency and therapeutics by glycolipid supplementGrant-in-Aid for Scientific Research (B)Kyoto UniversityMasahide AsanoFrom 01 Apr. 2016, To 31 Mar. 2019, Project Closedガングリオシド;LacCer合成酵素;ガラクトース転移酵素;神経細胞;軸索;ミエリン鞘;神経幹細胞;糖鎖;脳神経疾患
- Analysis of gut microbiota and gut immunity in the development of IgA nephropathy using its mouse modelGrant-in-Aid for Challenging Exploratory ResearchKyoto UniversityMASAHIDE ASANOFrom 01 Apr. 2015, To 31 Mar. 2018, Project ClosedIgA腎症;糖鎖;腸内細菌叢;腸内細菌
- The roles of histone modifications in the perinatal period.Grant-in-Aid for Scientific Research (C)Kyoto University;Kanazawa UniversityChie NaruseFrom 01 Apr. 2013, To 31 Mar. 2016, Project Closedマウス;脱メチル化酵素;ホメオティック変異;ヒストン脱メチル化;HP1;神経幹細胞;エピジェネティクス;発生;神経;Hox遺伝子
- Analysis of brain functions regulated by histone modification and development of psychiatric disorder animal modelsGrant-in-Aid for Scientific Research (B)Kyoto University;Kanazawa UniversityMasahide AsanoFrom 01 Apr. 2013, To 31 Mar. 2016, Project Closedエピジェネティクス;脳神経疾患;行動学;遺伝子改変マウス;脳・神経;遺伝子組換えマウス
- 生殖細胞の発生・分化においてヒストン修飾因子が果たす制御機構の解析Grant-in-Aid for Scientific Research on Priority AreasBiological SciencesKanazawa University浅野 雅秀From 01 Apr. 2011, To 31 Mar. 2013, Project Closed発生・分化;生殖細胞;始原生殖細胞;ヒストン修飾;遺伝子改変動物
- Analyses of mutant mice lacking histone modification factors.Grant-in-Aid for Young Scientists (B)Kanazawa UniversityChie NARUSEFrom 01 Apr. 2010, To 31 Mar. 2012, Project Closed発生・分化;生殖細胞;マウス;ヒストン修飾;遺伝子改変動物;始原生殖細胞
- 始原生殖細胞の初期分化におけるHP1γとヒストン修飾の機能解析Grant-in-Aid for Scientific Research on Priority AreasBiological SciencesKanazawa University浅野 雅秀From 01 Apr. 2009, To 31 Mar. 2011, Project Closed発生・分化;生殖細胞;始原生殖細胞;ヒストン修飾;遺伝子改変動物;始源生殖細胞;エピジェネティクス;細胞周期
- Analyses of infertility of HP1γ mutant miceGrant-in-Aid for Young Scientists (B)Kanazawa UniversityChie NARUSEFrom 01 Apr. 2008, To 31 Mar. 2010, Project ClosedHP1;マウス;生殖細胞;ヒストン修飾;エピジェネティクス;減数分裂
- EphA2/EphA4変異マウスを用いた腎嚢胞性疾患発症の分子メカニズムの解明Grant-in-Aid for Young Scientists (B)Kanazawa University成瀬 智恵From 01 Apr. 2006, To 31 Mar. 2008, Project ClosedEphA2;EphA4;ephrinA;MAPK;腎嚢胞性疾患;破骨細胞;腎臓形成;尿管芽形成
- 生殖細胞のインプリンティングおよび減数分裂におけるHP1γの機能解明Grant-in-Aid for Scientific Research on Priority AreasBiological SciencesKanazawa University浅野 雅秀From 01 Apr. 2006, To 31 Mar. 2008, Project Closed生殖細胞;エピジェネティックス;インプリンティング;遺伝子改変マウス;不妊
- β4-ガラクトース転移酵素-I欠損によるIga腎症発症機構の解析Grant-in-Aid for Scientific Research on Priority AreasBiological SciencesKanazawa University浅野 雅秀From 01 Apr. 2005, To 31 Mar. 2007, Project ClosedIgA腎症;ガラクトース転移酵素;高IgA血症;遺伝子ノックアウトマウス
- ORC4変異マウスを用いた個体レベルでの細胞周期研究Grant-in-Aid for Exploratory ResearchKanazawa University浅野 雅秀From 01 Apr. 2003, To 31 Mar. 2005, Project Closed複製開始点認識複合体;Orc4;トランスジェニックマウス;胚性幹細胞;DNA複製;細胞周期;遺伝子トラップ
list
Last Updated :2024/09/18
Education
Teaching subject(s)
- From 01 Apr. 2024, To 31 Mar. 2025Laboratory Animal Science8030, Spring, Faculty of Medicine, 1
- From 01 Apr. 2023, To 31 Mar. 2024Laboratory Animal Science8030, Spring, Faculty of Medicine, 1
- From 01 Apr. 2022, To 31 Mar. 2023Laboratory Animal Science8030, Spring, Faculty of Medicine, 1
- From Apr. 2018, To Mar. 2019Labolatory histo and cyto PathologySpring, 医学部（人間健康科学科）
- From Apr. 2019, To Mar. 2020Laboratory Animal ScienceSpring, 医学部（人間健康科学科）
- From Apr. 2020, To Mar. 2021Laboratory Animal ScienceSpring, 医学部（人間健康科学科）
- From Apr. 2021, To Mar. 2022Laboratory Animal ScienceSpring, 医学部（人間健康科学科）
