The study for evaluating the effects of perioperatively used drugs including anesthetics on human platelet functions and elucidating the underlying mechanisms.
Overview of the research
Platelets are essential for maintaining hemostasis. Therefore, information on the effects of perioperatively used drugs including anaesthetics on platelet functions is indispensable for patient care. Previously, the inhibitory effects of volatile anaesthetics on human platelet aggregation were shown in both in vitro ( Hirakata et al., 1995 and Hirakata et al., 1996) and in vivo studies ( Hirakata et al., 1997). With respect to intravenous anaesthetics, we have reported that propofol has both enhancing and suppressive effects on human platelet aggregation in vitro ( Hirakata et al., 1999), and ketamine inhibits human platelet aggregation possibly by suppression of inositol trisphosphate formation (Nakagawa et al., 2002). However, the effects of a number of drugs, which have recently become clinically applicable, on platelet functions remain to be examined. The aim of this study is to evaluate the effects of anesthetics on human platelet functions and to elucidate the underlying mechanisms.
Research Interests
pain clinic
platelet
anesthesia
hemodilutional autologous blood transfusion
COVID-19-associated coagulopathy and thrombosis
SARS-CoV-2
diabetes
rocuronium
propofol
dexmedetomidine
Research Areas
Life sciences, Hematology and oncology
Life sciences, Pharmacology
Life sciences, Anesthesiology
Papers
手術中の予期せぬ出血傾向に第XIII因子活性低下の影響が疑われた1症例
南迫 一請; 岩岡 佳実; 川本 修司; 澁谷 拓都; 小野 春菜; 江木 盛時
麻酔, Feb. 2025
SARS-CoV-2 Omicron variant spike protein maintains the ability to bind and activate human platelets: Comparison with the wild-type.
Anesthetic management of coronary artery reconstruction in a patient with myocardial ischemia caused by an anomalous origin of the right coronary artery running between the great vessels: a case report
JA Clinical Reports, 22 Aug. 2022, Peer-reviewed, Last author, Corresponding author
Agreement between continuous cardiac output measured by the fourth-generation FloTrac/Vigileo system and a pulmonary artery catheter in adult liver transplantation
A case of left ventricular free wall rupture after insertion of an IMPELLA® left ventricular assist device diagnosed by transesophageal echocardiography
Journal of Anesthesia & Clinical Research, Sep. 2020, Peer-reviewed, Lead author, Corresponding author
Use of argatroban in combination with nafamostat mesilate in open-heart surgery for a pediatric patient with heparin-induced thrombocytopenia type II: a case report
Shuji Kawamoto; Eriko Kusudo; Kazuhiko Fukuda
JA Clinical Reports, Dec. 2020, Peer-reviewed, Lead author, Corresponding author
Comparison between SPOTCHEM HS (dielectric blood coagulometry) and conventional coagulation test in cardiovascular surgery using cardiopulmonary bypass: A prospective observational study.
松本承大; 川本修司; 楠戸絵梨子; 田本光拡; 今井匠; 江木盛時
日本麻酔科学会学術集会(Web), 2024
Novel acute normovolemic hemodilution method prioritizing platelet function preservation
Does variant-derived SARS-CoV-2 spike protein directly cause platelet activation or hypercoagulability?-a prospective observational study.
楠戸絵梨子; 川本修司; 村田裕; 村田裕; 江木盛時
日本麻酔科学会学術集会(Web), 2023
Evaluation of the effects of acute normovolemic hemodilution on blood coagulability in middle/high-level liver resections using thromboelastography
川本修司; 武田親宗; 楠戸絵梨子; 松本承大; 村田裕; 村田裕; 江木盛時
日本麻酔科学会学術集会(Web), 2023
Cold vs Room temperature storage: Which is better for platelet function of blood stored in acute normovolemic hemodilution?
楠戸絵梨子; 川本修司; 松本承大; 村田裕; 村田裕; 江木盛時
日本麻酔科学会学術集会(Web), 2023
Agreement of Continuous Cardiac Output Measured by the Fourth-Generation FloTrac/Vigileo System and Pulmonary Artery Catheter in Adult Liver Transplantation
村田裕; 川本修司; 今井匠; 武田親宗; 溝田敏幸
日本麻酔科学会学術集会(Web), 2022
Use of remimazolam in living donor liver transplantation in patients with a family history of malignant hyperthermia