Platelets are essential for maintaining hemostasis. Therefore, information on the effects of perioperatively used drugs including anaesthetics on platelet functions is indispensable for patient care. Previously, the inhibitory effects of volatile anaesthetics on human platelet aggregation were shown in both in vitro ( Hirakata et al., 1995 and Hirakata et al., 1996) and in vivo studies ( Hirakata et al., 1997). With respect to intravenous anaesthetics, we have reported that propofol has both enhancing and suppressive effects on human platelet aggregation in vitro ( Hirakata et al., 1999), and ketamine inhibits human platelet aggregation possibly by suppression of inositol trisphosphate formation (Nakagawa et al., 2002). However, the effects of a number of drugs, which have recently become clinically applicable, on platelet functions remain to be examined. The aim of this study is to evaluate the effects of anesthetics on human platelet functions and to elucidate the underlying mechanisms.
研究キーワード
ペインクリニック
血小板
麻酔
希釈式自己血輸血
COVID-19関連血栓症
SARS-CoV-2
糖尿病
ロクロニウム
プロポフォール
デクスメデトミジン
研究分野
ライフサイエンス, 血液、腫瘍内科学
ライフサイエンス, 薬理学
ライフサイエンス, 麻酔科学
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