Basic Information

Faculty

• 農学部

Academic Degree

• 修士（農学）(京都大学)
• 博士（農学）(京都大学)

High School

• High School

  国立　大阪教育大学附属高等学校　天王寺校舎

Research History

• From Apr. 2020, To Mar. 2023

  Kyoto Prefectural University, 食保健学科, 非常勤講師
• From Feb. 2014, To Present

  京都大学大学院農学研究科, 応用生物科学専攻, 助教

Language of Instruction

• English
• Japanese

ID,URL

• J-Global ID

  201401035863995830

researchmap URL

• https://researchmap.jp/7000009503

Research

Research Topics, Overview of the research

• Research Topics

  Studies on metabolism and bioactivities of carotenoids and retinoids using marine bioproducts

• Overview of the research

  I'm exploring the metabolic pathways of carotenoids and retinoids in human and the enzymes responsible for them using compounds with characteristic chemical structures found in marine organisms as probes. I'm also evaluating the anti-inflammatory effects of carotenoids, retinoids, and their metabolites.

Research Areas

• Life sciences, Cell biology, Phospholipids, Sphingolipids, Mass spectrometry
• Life sciences, Food sciences, Carotenoid, Lipophilic food ingredients, LC-MS
• Life sciences, Marine/Aquatic life sciences, Marine vitamin

Papers

• Different suppressive effects of canthaxanthin and fucoxanthin on cellular responses of human dermal fibroblasts to ultraviolet A irradiation

  Nao Wakuda; Yuki Manabe; Takuya Seko; Tatsuya Sugawara

  Bioscience, Biotechnology, and Biochemistry, 16 Apr. 2025

  
• Potential of siphonaxanthin, a green algal carotenoid, to prevent obesity and related diseases

  Yuki Manabe; Tatsuya Sugawara

  Journal of Natural Medicines, 12 Apr. 2025

  
• Dehydrometabolites of siphonaxanthin, a carotenoid from green algae, suppress toll-like receptor 1/2-induced inflammatory response more strongly than siphonaxanthin

  Yuki Manabe; Tomoaki Nitta; Misato Ichihara; Takashi Maoka; Tatsuya Sugawara

  Journal of Biological Chemistry, Mar. 2025

  
• Oral administration of astaxanthin mitigates chronological skin aging in mice

  Shuyu Liu; Yuki Manabe; Tatsuya Sugawara

  Bioscience, Biotechnology, and Biochemistry, 24 Mar. 2025

  
• Preventive effects of dietary fucoxanthin on ultraviolet A induced photoaging in hairless mice

  Shuyu LIU; Shinsuke Mohri; Masao Tsukamoto; Yu Yanai; Yuki Manabe; Tatsuya Sugawara

  Journal of the Science of Food and Agriculture, 28 Aug. 2024

  
• Trophic niche partitioning of Mekong giant catfish Pangasianodon gigas in a tropical reservoir: evidence from stable isotope and fatty acid analyses

  Ayano Medo; Nobuhito Ohte; Keisuke Koba; Nobuaki Arai; Yasushi Mitsunaga; Hideaki Nishizawa; Manabu Kume; Thavee Viputhanumas; Kiattipong Kamdee; Chakrit Saengkorakot; Koki Ikeya; Iroha Yamada; Tatsuya Sugawara; Yuki Manabe; Akiko S. Goto; Ayako Yokoyama; Hiroyuki Yamane; Hiroki Kajitani; Daichi Kojima; Takashi Nose; Hiromichi Mitamura

  Limnology, 24 Feb. 2024, Peer-reviewed

  
• Binding Interaction Between Lauric Acid and Cluster of Differentiation 36 Underpinned by a Fluorescence- Intensifying Assay

  Satoshi Tsuzuki; Tatsuya Sugawara; Yuki Manabe; Masayuki Yamasaki; Tsutomu Sasaki

  Journal of Oleo Science, 2024, Peer-reviewed

  
• Striped catfish (Pangasianodon hypophthalmus) exploit food sources across anaerobic decomposition- and primary photosynthetic production-based food chains

  Ayano Medo; Nobuhito Ohte; Hiroki Kajitani; Takashi Nose; Yuki Manabe; Tatsuya Sugawara; Yuji Onishi; Akiko S. Goto; Keisuke Koba; Nobuaki Arai; Yasushi Mitsunaga; Manabu Kume; Hideaki Nishizawa; Daichi Kojima; Ayako Yokoyama; Toshiro Yamanaka; Thavee Viputhanumas; Hiromichi Mitamura

  Scientific Reports, 26 Aug. 2023, Peer-reviewed

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• Intestinal Absorption and Anti-Inflammatory Effects of Siphonein, a Siphonaxanthin Fatty Acid Ester from Green Algae

  Yuki MANABE; Shinano TAKAGI-HAYASHI; Shinsuke MOHRI; Tatsuya SUGAWARA

  Journal of Nutritional Science and Vitaminology, 28 Feb. 2023, Peer-reviewed, Lead author, Corresponding author

  
• Gly-Pro protects normal human dermal fibroblasts from UVA-induced damages via MAPK-NF-κB signaling pathway

  Shuyu Liu; Shinsuke Mohri; Yuki Manabe; Akika Ejima; Kenji Sato; Tatsuya Sugawara

  Journal of Photochemistry and Photobiology B: Biology, Dec. 2022, Peer-reviewed

  
• Early secretory pathway-resident Zn transporter proteins contribute to cellular sphingolipid metabolism through activation of sphingomyelin phosphodiesterase 1

  Sachiko Ueda; Yuki Manabe; Naoya Kubo; Naho Morino; Hana Yuasa; Miku Shiotsu; Tokuji Tsuji; Tatsuya Sugawara; Taiho Kambe

  American Journal of Physiology-Cell Physiology, 01 May 2022, Peer-reviewed

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• Oral supplementation of sea cucumber and its hydrolysate mitigates ultraviolet A‐induced photoaging in hairless mice

  Shuyu Liu; Yi Lu; Masahiro Kurono; Yoshiharu Matahira; Yuki Manabe; Tatsuya Sugawara

  Journal of the Science of Food and Agriculture, 30 Mar. 2022, Peer-reviewed

  
• Multivariate Analysis Reveals That Unsubstituted β-Ring and C8-Keto Structures Are Important Factors for Anti-Inflammatory Activity of Carotenoids

  Yuki Manabe; Nami Tomonaga; Takashi Maoka; Tatsuya Sugawara

  Nutrients, 21 Oct. 2021, Peer-reviewed, Lead author, Corresponding author

  
• Assessment of direct binding interaction between CD36 and its potential lipid ligands using a peptide mimic of the receptor labeled with a fluorophore

  Satoshi TSUZUKI; Yusaku KIMOTO; Masayuki YAMASAKI; Tatsuya SUGAWARA; Yuki MANABE; Kazuo INOUE; Tsutomu SASAKI

  Biomedical Research, 21 Sep. 2021, Peer-reviewed

  
• Dietary Ceramide Prepared from Soy Sauce Lees Improves Skin Barrier Function in Hairless Mice

  Kazushi Ohta; Shinobu Hiraki; Masakatsu Miyanabe; Tatsuro Ueki; Yuki Manabe; Tatsuya Sugawara

  Journal of Oleo Science, 24 May 2021, Peer-reviewed

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• Appearance of Intact Molecules of Dietary Ceramides Prepared from Soy Sauce Lees and Rice Glucosylceramides in Mouse Plasma

  Kazushi Ohta; Shinobu Hiraki; Masakatsu Miyanabe; Tatsuro Ueki; Kazuhiko Aida; Yuki Manabe; Tatsuya Sugawara

  Journal of Agricultural and Food Chemistry, 28 Jan. 2021, Peer-reviewed, Invited

  
• Dietary ceramide 2-aminoethylphosphonate, a marine sphingophosphonolipid, improves skin barrier function in hairless mice

  Nami Tomonaga; Yuki Manabe; Kazuhiko Aida; Tatsuya Sugawara

  Scientific Reports, Dec. 2020, Peer-reviewed

  
• Evaluation of Intestinal Absorption of Dietary Halocynthiaxanthin, a Carotenoid from the Sea Squirt Halocynthia roretzi

  Chiaki Ikeda; Yuki Manabe; Nami Tomonaga; Tatsuya Wada; Takashi Maoka; Tatsuya Sugawara

  Marine Drugs, 24 Nov. 2020, Peer-reviewed

  
• Absorption and Tissue Distribution of Siphonaxanthin from Green Algae.

  Zhuosi Li; Jiawen Zheng; Xiaolin Luo; Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  Marine drugs, 01 Jun. 2020, Peer-reviewed

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• Siphonaxanthin, a carotenoid from green algae Codium cylindricum, protects Ob/Ob mice fed on a high-fat diet against lipotoxicity by ameliorating somatic stresses and restoring anti-oxidative capacity.

  Jiawen Zheng; Yuki Manabe; Tatsuya Sugawara

  Nutrition research (New York, N.Y.), May 2020, Peer-reviewed

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• Exopolysaccharides from milk fermented by lactic acid bacteria enhance dietary carotenoid bioavailability in humans in a randomized crossover trial and in rats.

  Masashi Morifuji; Satomi Ichikawa; Masami Kitade; Tomoyuki Fukasawa; Yukio Asami; Yuki Manabe; Tatsuya Sugawara

  The American journal of clinical nutrition, 01 Apr. 2020, Peer-reviewed

  
• Gut microbial fatty acid metabolites (KetoA and KetoC) affect the progression of nonalcoholic steatohepatitis and reverse cholesterol transport metabolism in mouse model.

  Neng Tanty Sofyana; Jiawen Zheng; Yuki Manabe; Yuta Yamamoto; Shigenobu Kishino; Jun Ogawa; Tatsuya Sugawara

  Lipids, Mar. 2020, Peer-reviewed

  
• Siphonaxanthin, a carotenoid from green algae, suppresses advanced glycation end product-induced inflammatory responses

  Yuki Manabe

  Journal of Natural Medicines, 20 Jan. 2020, Peer-reviewed, Lead author

  
• Niemann‐Pick C1‐like 1 Promotes Intestinal Absorption of Siphonaxanthin

  Yuki Manabe; Misato Ichihara; Kyoko Fukuda; Nami Tomonaga; Zhuo‐Si Li; Yoshihide Yamanashi; Hiroshi Suzuki; Tappei Takada; Michinori Matsuo; Tatsuya Sugawara

  Lipids, Nov. 2019, Peer-reviewed, Lead author

  
• Convergent evolution of cytochrome P450s underlies independent origins of keto-carotenoid pigmentation in animals

  Nicky Wybouw; Andre H. Kurlovs; Robert Greenhalgh; Astrid Bryon; Olivia Kosterlitz; Yuki Manabe; Masahiro Osakabe; John Vontas; Richard M. Clark; Thomas Van Leeuwen

  Proceedings of the Royal Society B: Biological Sciences, 24 Jul. 2019, Peer-reviewed

  
• Analysis of Chemical Structures of Glucosylceramides from Rice and Other Foodstuffs.

  Tatsuya Sugawara; Kazuhiko Aida; Jingjing Duan; Nami Tomonaga; Yuki Manabe; Takashi Hirata

  Journal of nutritional science and vitaminology, 2019, Peer-reviewed

  
• Effects of feeding on plasma concentrations of vitamin A in captive African penguins (Spheniscus demersus)

  Yuki Manabe

  Journal of Veterinary Medical Science, 2019, Peer-reviewed

  
• Inhibitory effect of carotenoids on ligand-induced lipid raft translocation of immunoreceptors

  Manabe, Y.; Hirata, T.; Sugawara, T.

  Journal of Oleo Science, 2019, Peer-reviewed, Lead author

  
• Sphingoid bases of dietary ceramide 2-aminoethylphosphonate, a marine sphingolipid, absorb into lymph in rats

  Tomonaga, N.; Tsuduki, T.; Manabe, Y.; Sugawara, T.

  Journal of Lipid Research, 2019, Peer-reviewed

  
• Poly (d, l-lactide-co-glycolide)-phospholipid nanocarrier for efficient delivery of macular pigment lutein: absorption pharmacokinetics in mice and antiproliferative effect in Hep G2 cells

  Ranganathan, A.; Manabe, Y.; Sugawara, T.; Hirata, T.; Shivanna, N.; Baskaran, V.

  Drug Delivery and Translational Research, 2019, Peer-reviewed

  
• Polymeric chitosan-glycolipid nanocarriers for an effective delivery of marine carotenoid fucoxanthin for induction of apoptosis in human colon cancer cells (Caco-2 cells)

  Hindupur Ravi; Nawneet Kurrey; Yuki Manabe; Tatsuya Sugawara; Vallikannan Baskaran

  Materials Science and Engineering C, 01 Oct. 2018, Peer-reviewed

  
• Siphonaxanthin, a Carotenoid From Green Algae, Inhibits Lipogenesis in Hepatocytes via the Suppression of Liver X Receptor α Activity

  Jiawen Zheng; Zhuosi Li; Yuki Manabe; Minji Kim; Tsuyoshi Goto; Teruo Kawada; Tatsuya Sugawara

  Lipids, 01 Jan. 2018, Peer-reviewed

  
• Dietary astaxanthin can accumulate in the brain of rats

  Manabe, Y.; Komatsu, T.; Seki, S.; Sugawara, T.

  Bioscience, Biotechnology and Biochemistry, 2018, Peer-reviewed, Lead author

  
• Identification and biological activities of carotenoids from the freshwater alga Oedogonium intermedium

  Wang, N.; Manabe, Y.; Sugawara, T.; Paul, N.A.; Zhao, J.

  Food Chemistry, 2018, Peer-reviewed

  
• A novel role for scavenger receptor B1 as a contributor to the capture of specific volatile odorants in the nasal cavity

  Satoshi Tsuzuki; Yusaku Kimoto; Shinhye Lee; Tatsuya Sugawara; Yuki Manabe; Kazuo Inoue

  Biomedical Research (Japan), 2018, Peer-reviewed

  
• Anti-obesity properties of the dietary green Alga, Codium cylindricum, in high-fat diet-induced obese mice

  Li, Z.-S.; Zheng, J.-W.; Manabe, Y.; Hirata, T.; Sugawara, T.

  Journal of Nutritional Science and Vitaminology, 2018, Peer-reviewed

  
• A role for scavenger receptor B1 as a captor of specific fatty acids in tastbuds of circumvallate papillae

  Tsuzuki, S.; Lee, S.; Kimoto, Y.; Sugawara, T.; Manabe, Y.; Inoue, K.

  Biomedical Research (Japan), 2018, Peer-reviewed

  
• Antioxidant protection by astaxanthin in the citrus red mite (Acari: Tetranychidae)

  Atarashi, M.; Manabe, Y.; Kishimoto, H.; Sugawara, T.; Osakabe, M.

  Environmental Entomology, 2017, Peer-reviewed

  
• Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice

  Komatsu, T.; Sasaki, S.; Manabe, Y.; Hirata, T.; Sugawara, T.

  PLoS ONE, 2017, Peer-reviewed

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• Assessment of direct interaction between CD36 and an oxidized glycerophospholipid species

  Tsuzuki, S.; Yamasaki, M.; Kozai, Y.; Sugawara, T.; Manabe, Y.; Inoue, K.; Fushiki, T.

  Journal of Biochemistry, 2017, Peer-reviewed

  
• Digestion of Ceramide 2-Aminoethylphosphonate, a Sphingolipid from the Jumbo Flying Squid Dosidicus gigas, in Mice

  Tomonaga, N.; Manabe, Y.; Sugawara, T.

  Lipids, 2017, Peer-reviewed

  
• Selective absorption of dietary sphingoid bases from the intestine via efflux by p-glycoprotein in rats

  Fujii, A.; Manabe, Y.; Aida, K.; Tsuduki, T.; Hirata, T.; Sugawara, T.

  Journal of Nutritional Science and Vitaminology, 2017, Peer-reviewed

  
• Milk Fermented by Lactic Acid Bacteria Enhances the Absorption of Dietary Sphingomyelin in Rats

  Morifuji, M.; Kitade, M.; Oba, C.; Fukasawa, T.; Kawahata, K.; Yamaji, T.; Manabe, Y.; Sugawara, T.

  Lipids, 2017, Peer-reviewed

  
• Effect of Dietary Low-molecular-weight Hyaluronic Acid on Ear Swelling in 2, 4-Dinitro-1-fluorobenzene-treated BALB/c Mice

  Yuki Manabe

  Trace Nutrients Research, 2016, Peer-reviewed

  
• Imaginal feeding for progression of diapause phenotype in the two-spotted spider mite (Acari: Tetranychidae)

  Kawaguchi, S.; Manabe, Y.; Sugawara, T.; Osakabe, M.

  Environmental Entomology, 2016, Peer-reviewed

  
• Dietary Cerebroside from Sea Cucumber (Stichopus japonicus): Absorption and Effects on Skin Barrier and Cecal Short-Chain Fatty Acids

  Duan, J.; Ishida, M.; Aida, K.; Tsuduki, T.; Zhang, J.; Manabe, Y.; Hirata, T.; Sugawara, T.

  Journal of Agricultural and Food Chemistry, 2016, Peer-reviewed

  
• Phosphatidic Acid Produced by Phospholipase D Promotes RNA Replication of a Plant RNA Virus

  Hyodo, K.; Taniguchi, T.; Manabe, Y.; Kaido, M.; Mise, K.; Sugawara, T.; Taniguchi, H.; Okuno, T.

  PLoS Pathogens, 2015, Peer-reviewed

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• Milk Phospholipids Enhance Lymphatic Absorption of Dietary Sphingomyelin in Lymph-Cannulated Rats

  Morifuji, M.; Higashi, S.; Oba, C.; Ichikawa, S.; Kawahata, K.; Yamaji, T.; Itoh, H.; Manabe, Y.; Sugawara, T.

  Lipids, 2015, Peer-reviewed

  
• Biodegradable poly (lactic-co-glycolic acid)-polyethylene glycol nanocapsules: An efficient carrier for improved solubility, bioavailability, and anticancer property of lutein

  Arunkumar, R.; Prashanth, K.V.H.; Manabe, Y.; Hirata, T.; Sugawara, T.; Dharmesh, S.M.; Baskaran, V.

  Journal of Pharmaceutical Sciences, 2015, Peer-reviewed

  
• The green algal carotenoid siphonaxanthin inhibits adipogenesis in 3T3-L1 preadipocytes and the accumulation of lipids in white adipose tissue of KK-Aymice

  Li, Z.-S.; Noda, K.; Fujita, E.; Manabe, Y.; Hirata, T.; Sugawara, T.

  Journal of Nutrition, 2015, Peer-reviewed

  
• Siphonaxanthin, a green algal carotenoid, as a novel functional compound

  Sugawara, T.; Ganesan, P.; Li, Z.; Manabe, Y.; Hirata, T.

  Marine Drugs, 2014, Peer-reviewed

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• Suppressive effects of carotenoids on the antigeninduced degranulation in RBL-2H3 rat basophilic leukemia cells

  Manabe, Y.; Hirata, T.; Sugawara, T.

  Journal of Oleo Science, 2014, Peer-reviewed, Lead author

  
• Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells

  Ganesan, P.; Noda, K.; Manabe, Y.; Ohkubo, T.; Tanaka, Y.; Maoka, T.; Sugawara, T.; Hirata, T.

  Biochimica et Biophysica Acta - General Subjects, 2011, Peer-reviewed

  

Misc.

• 健常人において発酵乳と野菜の同時摂取はカロテノイドの吸収を促進させる

  森藤 雅史; 市川 聡美; 宮山 晶美[北出]; 木村 勝紀; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022

  
• 植物由来セラミドの摂取が老齢マウスの行動に与える影響

  西本 匠; 開 忍; 宮鍋 征克; 毛利 晋輔; 真鍋 祐樹; 吉原 亨; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022

  
• ミクログリアの炎症応答に対するシフォナキサンチンの抑制効果とその作用メカニズム

  上田 愛佳; 真鍋 祐樹; 毛利 晋輔; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022

  
• 培養細胞を用いたナマコ酵素分解物由来グリシルプロリンによる光老化抑制効果の評価

  Shuyu Liu; 毛利 晋輔; 真鍋 祐樹; 佐藤 健司; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022

  
• 真皮線維芽細胞の紫外線障害に対するカロテノイドの保護効果

  涌田 奈櫻; 真鍋 祐樹; 毛利 晋輔; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022

  
• Biological activities of marine carotenoids for human health

  Yuki Manabe

  Carotenoid Science, 2017, Peer-reviewed, Invited

  
• 分子種に着目したプラズマローゲンの小腸上皮細胞への取り込みの評価

  石原優花; 乙木百合香; 仲川清隆; 毛利晋輔; 真鍋祐樹; 菅原達也

  日本栄養・食糧学会近畿支部大会講演要旨集, 2021

  
• スフィンゴ脂質によるグルカゴン様ペプチド-1(GLP-1)分泌促進効果

  旗野翠; 真鍋祐樹; 大日向耕作; 菅原達也

  日本栄養・食糧学会近畿支部大会講演要旨集, 2015

  
• 脂質ラフトを介した免疫担当細胞の活性化に対するカロテノイドの影響

  眞鍋祐樹; 酒井祥太; 菅原達也; 平田孝

  日本農芸化学会大会講演要旨集(Web), 2012

  
• 免疫担当細胞におけるカロテノイドの脂質ラフトを介した受容体応答の制御

  眞鍋祐樹; 酒井祥太; 菅原達也; 平田孝

  日本食品科学工学会大会講演集, 2011

  
• 菌体由来安定同位体ラベル化スフィンゴ脂質の吸収動態の評価

  川上祥子; 安藤晃規; 小川順; 友永奈美; 真鍋祐樹; 菅原達也

  日本栄養・食糧学会大会講演要旨集, 22 Apr. 2019

  
• 食餌性緑藻由来シフォナキサンチンの体内分布と代謝

  新多 智明; 李 卓思; 市原 美里; 真鍋 祐樹; 眞岡 孝至; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2017

  
• クロマグロ皮由来スフィンゴミエリンの化学構造解析

  大谷 友佑; 開 忍; 宮鍋 征克; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2017

  
• 筋収縮様式の違いが筋内Phosphatidic Acid濃度およびmTORC1活性化に及ぼす影響

  阿藤 聡; 真鍋 祐樹; 木戸 康平; 蒔苗 裕平; 菅原 達也; 藤田 聡

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Novel Functions of Siphonaxanthin from Green Algae

  菅原達也; 真鍋祐樹

  月刊ファインケミカル, 2020

  
• Survey of carotenoids content in green algae

  林志菜野; 川越大; 林裕一; 真鍋祐樹; 菅原達也

  Trace Nutrients Research, 2018

  
• カロテノイドの抗炎症作用 (特集 食品と疾病 : カロテン)

  真鍋 祐樹; 菅原 達也

  Functional food : 機能性食品の基礎から臨床へ, 2013

  
• カロテノイドのマスト細胞に対する脱顆粒抑制作用

  菅原達也; 真鍋祐樹

  オレオサイエンス, 01 Oct. 2012

  
• DIETARY MARINE SPHINGOLIPIDS AS FUNCTIONAL FOOD COMPONENTS

  Tatsuya Sugawara; Nami Tomonaga; Duan Jingjin; Yuki Manabe; Tsuyoshi Tsuduki; Takashi Hirata

  ANNALS OF NUTRITION AND METABOLISM, 2017

  
• EXPLORATION OF BIOFUNCTION OF SIPHONAXANTHIN, A CAROTENOID DERIVED FROM GREEN ALGAE, ON HEPATIC LIPOGENESIS

  Zheng Jiawen; Li Zhuosi; Yuki Manabe; Minji Kim; Tsuyoshi Goto; Teruo Kawada; Tatsuya Sugawara

  ANNALS OF NUTRITION AND METABOLISM, 2017

  
• カロテノイドによるミカンハダニの酸化ストレス耐性

  新 真理; 真鍋祐樹; 岸本英成; 菅原達也; 刑部正博

  Oct. 2016, Peer-reviewed

  
• Protective function of body pigments from oxidative stress in Panonychus citri

  M. Atarashi; Y. Manabe; H. Kishimoto; T. Sugawara; M. Osakabe

  8th Symposium of the EURopean Association of ACarologists, Jul. 2016

  
• Characterization of intestinal digestion of Ceramide 2-aminoethylphosphonate, a Marine Sphingolipid

  N. Tomonaga; D. Qi; Y. Manabe; T. Sugawara

  107th AOCS Annual Meeting & Expo, 2016

  
• Intestinal digestion of ceramide 2-aminoethylphosphonate a marine sphingolipid from squid

  Nami Tomonaga; Dan Qi; Yuki Manabe; Tatsuya Sugawara

  12th Asian Congress of Nutrition, 2015

  
• Functional characterization of siphonaxanthin on lipid metabolism

  Jiawen Zheng; Zhuosi Li; Yuki Manabe; Tatsuya Sugawara

  12th Asian Congress of Nutrition, 2015

  
• Siphonaxanthin inhibits mast cell degranulation through a stimulation of sphingomyelin synthesis

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  the 7th International Conference and Exhibition on Nutraceuticals and Functional Food, Oct. 2014

  
• Siphonaxanthin, a marine carotenoid from green algae, suppresses mast cell degranulation via an alteration of sphingomyelin metabolism

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  1st Asian Conference on Oleo Science, Sep. 2014

  
• Dietary astaxanthin prevents UVA-induced skin photo aging in hairless mice

  Suguru Sasaki; Toshiyuki Komatsu; Yuki Manabe; Hitomi Sato; Takashi Hirata; Tatsuya Sugawara

  the 7th International Conference and Exhibition on Nutraceuticals and Functional Food, 2014

  
• Anti-obesity effect of siphonaxanthin a green algal carotenoid

  Zhuosi Li; Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  the 7th International Conference and Exhibition on Nutraceuticals and Functional Food, 2014

  
• Siphonaxanthin a green algal carotenoid inhibits adipogenesis in 3T3-L1 preadipocytes and accumulation of lipids in white adipose tissue of KK-Ay mice

  Zhuosi Li; Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  1st Asian Conference on Oleo Science, 2014

  
• Inhibitory effects of marine-derived carotenoids on mast cell degranulation

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  International Society for Nutraceuticals and Functional Foods 2013, 2013

  
• 脂質ラフトを介した免疫担当細胞の活性化に与える海洋カロテノイドの影響

  眞鍋 祐樹; 酒井 祥太; 菅原 達也; 平田 孝

  日本栄養・食糧学会大会講演要旨集, Apr. 2012

  
• 高親和性IgE受容体の凝集阻害を介したカロテノイドの脱顆粒抑制作用

  眞鍋 祐樹; 酒井 祥太; 菅原 達也; 平田 孝

  日本栄養・食糧学会大会講演要旨集, Apr. 2011

  
• Carotenoid from green algae effectively suppresses mast cell degranulation via an alteration of cellular sphingomyelin metabolism

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  The International Chemical Congress of Pacific Basin Societies (Pacifichem) 2015

  
• Siphonaxanthin, a marine carotenoid from green algae, attenuates mast cell degranulation by regulating sphingolipid metabolism

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  12th Asian Congress of Nutrition

  

Presentations

• マリンカロテノイドから紐解くカロテノイドの吸収と代謝

  真鍋祐樹

  第1回 京都カロテノイド研究者の集い, 26 Jul. 2024, Invited

  
• Alteration of anti-inflammatory property of siphonaxanthin by dehydrogenase activity

  Yuki Manabe; Tatsuya Sugawara

  第78回日本栄養・食糧学会大会, 25 May 2024

  
• Assessment of anti-inflammatory activity of carotenoids using an LC/MS-based lipidomics approach

  Yuki Manabe

  日本油化学会 規格試験法委員会主催 特別セミナー, 27 Feb. 2024, Invited

  
• 健常人において発酵乳と野菜の同時摂取はカロテノイドの吸収を促進させる

  森藤 雅史; 市川 聡美; 宮山 晶美[北出]; 木村 勝紀; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022, (公社)日本栄養・食糧学会

  
• 植物由来セラミドの摂取が老齢マウスの行動に与える影響

  西本 匠; 開 忍; 宮鍋 征克; 毛利 晋輔; 真鍋 祐樹; 吉原 亨; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022, (公社)日本栄養・食糧学会

  
• ミクログリアの炎症応答に対するシフォナキサンチンの抑制効果とその作用メカニズム

  上田 愛佳; 真鍋 祐樹; 毛利 晋輔; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022, (公社)日本栄養・食糧学会

  
• 培養細胞を用いたナマコ酵素分解物由来グリシルプロリンによる光老化抑制効果の評価

  Shuyu Liu; 毛利 晋輔; 真鍋 祐樹; 佐藤 健司; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022, (公社)日本栄養・食糧学会

  
• 真皮線維芽細胞の紫外線障害に対するカロテノイドの保護効果

  涌田 奈櫻; 真鍋 祐樹; 毛利 晋輔; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, May 2022, (公社)日本栄養・食糧学会

  
• Potential of siphonaxanthin for disease control and prevention

  Tatsuya Sugawara; Yuki Manabe

  The International Symposium on Carotenoids, 11 Jul. 2023, Invited

  
• Dehydrogenation increases anti-inflammatory activity of siphonaxanthin

  Yuki Manabe; Takashi Maoka; Tatsuya Sugawara

  The International Symposium on Carotenoids, 09 Jul. 2023

  
• Evaluation of inhibitory effect of halocynthiaxanthin on differentiation into pro-inflammatory macrophages and its gastrointestinal absorption

  Chiaki Ikeda; Yuki Manabe; Nami Tomonaga; Tatsuya Wada; Takashi Maoka; Tatsuya Sugawara

  The International Symposium on Carotenoids, 09 Jul. 2023

  
• マリンカロテノイドの食品機能性の探索

  真鍋 祐樹; 菅原 達也

  日本ビタミン学会第75回大会, 18 Jun. 2023, Invited

  
• 紫外線障害から皮膚を保護するカロテノイドの探索

  涌田奈櫻; 真鍋祐樹; 毛利晋輔; 菅原達也

  第77回日本栄養・食糧学会大, 12 May 2023

  
• マウスにおける菌体由来ラベル化スフィンゴ脂質の吸収動態の解析

  宮原禄; 川上祥子; 奥田知生; 安藤晃規; 小川順; 毛利晋輔; 真鍋祐樹; 菅原達也

  第77回日本栄養・食糧学会大会, 12 May 2023

  
• 農芸化学者が見た食品成分カロテノイドの魅力

  真鍋祐樹

  令和5年度健康食品管理士/食の安全管理士会近畿支部第1回研修会, 16 Apr. 2023, Invited

  
• Poly (D, L-lactide-co-glycolide)-phospholipid nanocarrier for efficient delivery of carotenoids

  Baskaran Vallikannan; Arunkumar Ranganathan; Yuki Manabe; Tatsuya Sugawara; Takashi Hirata; Ravi Hindupur; Veeresh Toragall

  22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan, 09 Dec. 2022, Invited

  
• Nutraceutical potential of siphinaxanthin, a green algal carotenoid

  Tatsuya Sugawara; Yuki Manabe

  22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan, 08 Dec. 2022, Invited

  
• Milk fermented by lactic acid bacteria enhance dietary carotenoid bioavailability in humans in a randomized crossover trial

  Masashi Morifuji; Satomi Ichikawa; Masami Kitade-Miyayama; Yuki Manabe; Tatsuya Sugawara

  22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan, 06 Dec. 2022

  
• Potential skin protective effects against photoaging of sea cucumber derived indigestible peptide

  SHUYU LIU; Yi Lu; Masahiro Kurono; Yoshiharu Matahira; Shinsuke Mohri; Yuki Manabe; Kenji Sato; Tatsuya Sugawara

  22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan, 06 Dec. 2022

  
• Qualitative and quantitative analysis of sphingomyelin from Atlantic salmon, Salmo salar

  Saki Nishimoto; Shinsuke Mohri; Yuki Manabe; Tatsuya Sugawara

  22nd IUNS-ICN International Congress of Nutrition in Tokyo, Japan, 06 Dec. 2022

  
• 抗炎症作用に注目した出汁に含まれる食品機能成分の評価

  毛利晋輔; 真鍋祐樹; 高橋春弥; 後藤剛; 菅原達也

  日本食品科学工学会 第5回関西支部大会, 19 Nov. 2022

  
• サーモン頭部スフィンゴミエリンの化学特性の解析と超臨界二酸化炭素を用いた抽出方法の検討

  西本早希; 毛利晋輔; 真鍋祐樹; 菅原達也

  日本食品科学工学会 第5回関西支部大会, 19 Nov. 2022

  
• アトランティックサーモンに含まれるスフィンゴミエリンの定量と構造解析

  西本早希; 毛利晋輔; 真鍋祐樹; 菅原達也

  第61回日本栄養・食糧学会近畿支部大会, 15 Oct. 2022

  
• 真皮線維芽細胞におけるカロテノイドの紫外線障害抑制作用

  涌田 奈櫻; 真鍋 祐樹; 毛利 晋輔; 菅原 達也

  第34 回カロテノイド研究談話会, 18 Sep. 2022

  
• ヒト肝細胞モデルを用いたシフォナキサンチンの生体内代謝の検討

  真鍋 祐樹; 毛利 晋輔; 菅原 達也

  第34 回カロテノイド研究談話会, 17 Sep. 2022

  
• 食品メタボロームへの機能性情報付与による出汁に含まれる抗炎症化合物の探索および作用機序の解明

  毛利 晋輔; 真鍋 祐樹; 高橋 春弥; 後藤 剛; 菅原 達也

  令和４年度日本食品分析学会, 13 Sep. 2022

  
• 真皮線維芽細胞の紫外線障害に対するカロテノイドの保護効果

  涌田 奈櫻; 真鍋 祐樹; 毛利 晋輔; 菅原 達也

  第76回日本栄養・食糧学会大会, 12 Jun. 2022

  
• 培養細胞を用いたナマコ酵素分解物由来グリシルプロリンによる光老化抑制効果の評価

  LIU SHUYU; 毛利 晋輔; 真鍋 祐樹; 佐藤 健司; 菅原 達也

  第76回日本栄養・食糧学会大会, 11 Jun. 2022

  
• 植物由来セラミドの摂取が老齢マウスの行動に与える影響

  西本 匠; 開 忍; 宮鍋 征克; 毛利 晋輔; 真鍋 祐樹; 吉原 亨; 菅原 達也

  第76回日本栄養・食糧学会大会, 11 Jun. 2022

  
• ミクログリアの炎症応答に対するシフォナキサンチンの抑制効果とその作用メカニズム

  上田 愛佳; 真鍋 祐樹; 毛利 晋輔; 菅原 達也

  第76回日本栄養・食糧学会大会, 11 Jun. 2022

  
• 健常人において発酵乳と野菜の同時摂取はカロテノイドの吸収を促進させる

  森藤 雅史; 市川 聡美; 宮山(北出) 晶美; 木村 勝紀; 真鍋 祐樹; 菅原 達也

  第76回日本栄養・食糧学会大会, 11 Jun. 2022

  
• 小腸上皮モデルを用いたヨーグルトによるカロテノイド吸収促進作用機構の評価

  村上 俊輔; 中尾 碧; 森藤 雅史; 毛利 晋輔; 真鍋 祐樹; 菅原 達也

  第76回日本栄養・食糧学会大会, 11 Jun. 2022

  
• Involvement of NPC1L1 in intestinal absorption of siphonaxanthin

  Yuki Manabe; Tatsuya Sugawara

  日本農芸化学会2022年度京都大会, 18 Mar. 2022, Invited

  
• メタボロミクスによる代謝物一斉評価系を活用したトマトに含まれるアディポネクチン様活性化合物の探索

  毛利 晋輔; 高橋 春弥; 坂井 麻衣子; 脇 尚子; 高橋 慎吾; 相澤 宏一; 菅沼 大行; 荒 武; 真鍋 祐樹; 菅原 達也; 松村 康生; 柴田 大輔; 後藤 剛; 河田 照雄

  日本栄養・食糧学会大会講演要旨集, Jul. 2021, (公社)日本栄養・食糧学会

  
• コメ由来グルコシルセラミド摂取がマウスの行動に与える影響

  小須田 帆南; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Jul. 2021, (公社)日本栄養・食糧学会

  
• ナマコ摂取による皮膚光老化抑制効果の評価と生理活性ペプチドの探索

  Liu Shuyu; Lu Yi; 黒野 昌洋; 又平 芳春; 真鍋 祐樹; 佐藤 健司; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Jul. 2021, (公社)日本栄養・食糧学会

  
• 磁気ナノビーズ法を用いたスフィンゴイド塩基結合タンパク質の探索

  太田 知志; 飯泉 陽介; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Jul. 2021, (公社)日本栄養・食糧学会

  
• 老齢マウスを用いたアスタキサンチン摂取による抗老化作用の評価

  北野 伶美; Liu Shu-Yu; 友永 奈美; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2020, (公社)日本栄養・食糧学会

  
• Nrt2の活性化を介したシフォナキサンチン代謝産物の抗炎症作用

  真鍋 祐樹; 新多 智明; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2020, (公社)日本栄養・食糧学会

  
• シフォナキサンチンの代謝を担う酵素の探索

  清水 亮佑; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2020, (公社)日本栄養・食糧学会

  
• コメ由来グルコシルセラミド摂取がマウスの精神ストレスに与える影響

  小須田 帆南; 太田 和志; 友永 奈美; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2020, (公社)日本栄養・食糧学会

  
• 遊離セラミドの消化管吸収評価

  太田 知志; 開 忍; 宮鍋 征克; 植木 達朗; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2020, (公社)日本栄養・食糧学会

  
• 菌体由来安定同位体ラベル化スフィンゴ脂質の吸収動態の評価

  川上祥子; 安藤晃規; 小川順; 友永奈美; 真鍋祐樹; 菅原達也

  日本栄養・食糧学会大会講演要旨集, 22 Apr. 2019, (公社)日本栄養・食糧学会

  
• ハロシンチアキサンチンの消化管吸収

  池田千晶; 真鍋祐樹; 友永奈美; 和田竜哉; 眞岡孝至; 菅原達也

  日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集, 2019

  
• シフォナキサンチン代謝産物の抗炎症作用の評価と作用メカニズムの解明

  真鍋祐樹; 新多智明; 菅原達也

  日本農芸化学会大会講演要旨集(Web), 2019

  
• クロマグロ皮由来スフィンゴミエリンの化学構造解析

  大谷 友佑; 開 忍; 宮鍋 征克; 真鍋 祐樹; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2017, (公社)日本栄養・食糧学会

  
• 食餌性緑藻由来シフォナキサンチンの体内分布と代謝

  新多 智明; 李 卓思; 市原 美里; 真鍋 祐樹; 眞岡 孝至; 菅原 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2017, (公社)日本栄養・食糧学会

  
• スフィンゴ脂質によるグルカゴン様ペプチド‐1(GLP‐1)分泌促進効果

  旗野翠; 真鍋祐樹; 大日向耕作; 菅原達也

  日本栄養・食糧学会近畿支部大会および公開シンポジウム講演抄録集, 01 Sep. 2015

  
• 海産機能性成分研究におけるLC-MSの利用

  真鍋 祐樹

  バイオアナリシス, マルチオミクス分析の最前線 ～地域産業への先端計測・バイオインフォマティクス技術導入によるイノベーション促進を目指して～, 13 Nov. 2020, Invited

  
• Anti-inflammatory effect of siphonaxanthin and its underlying molecular mechanisms

  Yuki Manabe; Natsuki Hashimoto; Toshiro Okazaki; Takashi Hirata; Tatsuya Sugawara

  7th International Conference on Food Factors, Dec. 2019

  
• Anti-Allergic Effect of Siphonaxanthin and its Molecular Mechanism

  Yuki Manabe; Natsuki Hashimoto; Toshiro Okazaki; Takashi Hirata; Tatsuya Sugawara

  Marine Biotechnology Conference, Sep. 2019

  
• Metabolic conversion of siphonaxanthin, a carotenoid from green algae, increases its anti-inflammatory activity

  Yuki Manabe; Tomoaki Nitta; Zhou-Si Li; Jia-Wen Zheng; Misato Ichihara; Xiao-Lin Luo; Takashi Hirata; Takashi Maoka; Tatsuya Sugawara

  Asian Congress of Nutrition 2019, Aug. 2019

  
• マリンカロテノイドの生物活性の探索

  真鍋 祐樹

  マリンケミカルバイオロジー研究会2018講演会, 26 Mar. 2018, Invited

  
• Green Algal Carotenoid, Siphonaxanthin, Modulates the Inflammatory Responses of Monocytes and Macrophages

  Yuki Manabe

  The Asian Conference on Oleo Sience, 11 Sep. 2017

  
• Carotenoid from green algae effectively suppresses mast cell degranulation via an alteration of cellular sphingomyelin metabolism

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  The International Chemical Congress of Pacific Basin Societies (Pacifichem) 2015, Dec. 2015

  
• Siphonaxanthin inhibits mast cell degranulation through a stimulation of sphingomyelin synthesis

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  the 7th International Conference and Exhibition on Nutraceuticals and Functional Food, Oct. 2014

  
• Siphonaxanthin, a marine carotenoid from green algae, suppresses mast cell degranulation via an alteration of sphingomyelin metabolism

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  1st Asian Conference on Oleo Science, Sep. 2014

  
• Inhibitory effects of marine-derived carotenoids on mast cell degranulation

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  International Society for Nutraceuticals and Functional Foods 2013, 2013

  
• Siphonaxanthin, a marine carotenoid from green algae, attenuates mast cell degranulation by regulating sphingolipid metabolism

  Yuki Manabe; Takashi Hirata; Tatsuya Sugawara

  12th Asian Congress of Nutrition

  

Books and Other Publications

• ファルマシア（トピックス：レチノール飽和化酵素によるフェロトーシスの制御）

  真鍋祐樹, Others

  日本薬学会, Mar. 2024

  
• 食品化学新聞第3017号（寄稿：シフォナキサンチンの抗炎症作用と食品への応用可能性）

  真鍋祐樹, Others, シフォナキサンチンの抗炎症作用と食品への応用可能性

  食品化学新聞社, Mar. 2024

  
• カロテノイドの科学 : 基礎, 研究の新展開, 生理活性

  高市, 真一, Contributor, 第20章 緑藻シフォナキサンチンの機能性に関する基礎研究

  シーエムシー出版, Mar. 2024

  Find Kyoto University's collection of books :

  
• 花粉症等アレルギー疾患予防食品の開発

  今井 伸二郎, Contributor, 第６章 藻類由来カロテノイド

  シーエムシー出版, 29 Jul. 2021

  
• 水産・食品化学実験ノート

  落合 芳博; 石崎 松一郎; 神保 充, Contributor, 脂質の過酸化物価と酸価の測定

  恒星社厚生閣, Mar. 2019, Not refereed

  
• 食と微生物の事典

  北本 勝ひこ; 春田 伸; 丸山 潤一; 後藤 慶一; 尾花 望; 齋藤 勝晴, Contributor, 色素を作る微生物

  朝倉書店, 2017, Not refereed

  Find Kyoto University's collection of books :

  
• 栄養・食糧学用語辞典

  日本栄養; 食糧学会, Contributor

  2015, Not refereed

  
• 食物アレルギーの現状とリスク低減化食品素材の開発

  森山 達哉; 穐山 浩, Contributor, 第4編アレルギー対策食品・素材の開発 第1章抗アレルギー食品・素材 12．海藻カロテノイド

  シーエムシー出版, 2015, Not refereed

  

Awards

• 04 Dec. 2019

  7th International Conference on Food Factors, Young Investigator Award
• 22 Jun. 2019

  日本微量栄養素学会, 優秀発表賞
• 22 Nov. 2014

  日本水産学会近畿支部, 平成２６年度日本水産学会近畿支部例会優秀発表賞
• 09 Oct. 2014

  Japan Oil Chemists' Society, 日本油化学会第５３回年会ヤングフェロー賞
• 09 Nov. 2013

  International Society for Nutraceuticals and Functional Foods, 2013 ISNFF Conference and Exhibition, Student Poster Awards
• 04 Sep. 2013

  Japan Oil Chemists' Society, 日本油化学会第52回年会　学生奨励賞
• 15 Oct. 2011

  日本栄養・食糧学会近畿支部, 日本栄養・食糧学会近畿支部若手奨励賞

External funds: Kakenhi

• カロテノイドデヒドロゲナーゼの同定とそれを制御する食品成分の探索

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38050:Food sciences-related

  Kyoto University

  真鍋 祐樹

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  カロテノイド;脱水素反応;食べ合わせ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K08745/
• 食品成分として未開拓なホスホイノシトール含有スフィンゴ脂質の評価

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38050:Food sciences-related

  Kyoto University

  菅原 達也

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  スフィンゴ脂質;食品機能;消化吸収

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K26851/
• 食品成分として未開拓なホスホイノシトール含有スフィンゴ脂質の評価

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38050:Food sciences-related

  Kyoto University

  菅原 達也

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  スフィンゴ脂質;食品機能

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02158/
• 長鎖脂肪酸とその細胞への取り込みを担う受容体の特異的結合相互作用の立証

  Grant-in-Aid for Scientific Research (C)

  Basic Section 59040:Nutrition science and health science-related

  Kyoto University

  都築 巧

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  長鎖脂肪酸;CD36;特異的結合相互作用;蛍光増強試験;構造解析;結合試験;結合様式

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K11825/
• Assessment of anti-inflammatory activity of carotenoids using a multivariate analysis-based approach

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38050:Food sciences-related

  Kyoto University

  Manabe Yuki

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  カロテノイド;多変量解析;抗炎症作用;NF-κB;インターフェロン制御因子;レチノイド;Nrf2;プロビタミンA;デヒドロ代謝産物;動脈硬化;プロファイル解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K05487/
• Elucidation of the mechanism of skin barrier improving effect of sphingolipids focusing on absorption and metabolism

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38050:Food sciences-related

  Kyoto University

  Tatsuya SUGAWARA

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  セラミド;スフィンゴ脂質;安定同位体;結合タンパク質;消化管;消化吸収;皮膚;食品機能;吸収;代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02931/
• Elucidation of the mechanisms on the capture and recognition of food odorants that have fatty and waxy notes in the nasal cavity of mammals

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38050:Food sciences-related

  Kyoto University

  SATOSHI TSUZUKI

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  CD36;SR-B1;食品有香成分;脂肪族アルデヒド;模擬受容体ペプチド;特異的結合;GST融合タンパク質;三次元構造;食品有香物質;クラスBスカベンジャー受容体;香調ー活性相関;結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K05912/
• Investigation of Outline of Metabolic Conversion of Siphonaxanthin

  Grant-in-Aid for Early-Career Scientists

  Basic Section 38050:Food sciences-related

  Kyoto University

  Yuki Manabe

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  シフォナキサンチン;カロテノイド;生体内代謝;代謝産物;抱合体;抗炎症作用;Nrf2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14406/
• Elucidation of recognition mechanisms of fatty acids and their related substances by class B scavenger receptors

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  SATOSHI TSUZUKI

  From 21 Oct. 2016, To 31 Mar. 2019, Project Closed

  クラスBスカベンジャー受容体;長鎖脂肪酸;酸化型リポ蛋白質;酸化型リン脂質;CD36;脂肪族アルデヒド;嗅上皮;酸化型リポタンパク質;SR-B1;酸化型リポタンパク室;SR-BI;生体分子;食品;脂質;蛋白質;動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07733/
• Protective effect of dietary carotenoid on the skin

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Tatsuya SUGAWARA

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  食品機能;光老化;シフォナキサンチン;カロテノイド;皮膚;緑藻;食品;栄養学;生理活性;老化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14926/
• Elucidation of absorption and pharmacokinetics of dietary sphingolipids based on qualitative and quantitative analysis

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Tatsuya Sugawara

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  セラミド;消化管;スフィンゴ脂質;質量分析;吸収;安定同位体;消化管吸収;脂質;食品;栄養学;生体分子;分析科学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04923/
• A basic study for utilization of siphonaxanthin as a new anti-allergic compound

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yuki Manabe

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  カロテノイド;抗炎症作用;マスト細胞;消化管吸収;アレルギー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18697/

External funds: others

• 哺乳動物体内におけるカロテノイド異性化反応の探求

  The Japan Food Chemical Research Foundation, 令和6年度研究助成

  From 01 Apr. 2024, To 31 Mar. 2025

  Yuki Manabe
• カロテノイドの消化管吸収に関わる分子メカニズムとその生理的意義の解明

  奨励研究助成A-1

  LOTTE FOUNDATION, Lotte Research Promotion Grant

  From 01 Apr. 2023, To 31 Mar. 2025

  Yuki Manabe

  代表
• 緑藻由来シフォネインの消化吸収メカニズムの解明

  公益社団法人　日本栄養・食糧学会, 若手研究助成

  From 01 Apr. 2020, To 31 Mar. 2021

  Yuki Manabe
• 神経炎症を抑制するカロテノイドの探索

  一般財団法人　旗影会, 研究助成

  From 01 Apr. 2019, To 31 Mar. 2020

  Yuki Manabe

  Tatsuya Sugawara
• 食用緑藻に由来するカロテノイドの生体内代謝の解明

  一般財団法人　生産開発科学研究所, 第４回生研学術奨励資金

  From 01 Dec. 2015, To 30 Nov. 2016

  Yuki Manabe

  Takashi Maoka
• 水産物カロテノイドの消化管吸収機構の解明

  財団法人　東和食品研究振興会, 学術奨励金

  From 09 Jun. 2015, To 31 Mar. 2016

  Yuki Manabe

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Course in Marine Bioresource Science II

  5367, Fall, Faculty of Agriculture, 6
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Course in Marine Bioresource Science I

  5365, Spring, Faculty of Agriculture, 6
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Course in Technology of Marine Bio-products

  DG10, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Course in Technology of Marine Bio-products

  DG10, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar in Marine Bio-production

  5301, Year-long, Faculty of Agriculture, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Foreign Literature in Marine Bioresource Science

  5355, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Marine Biological Science

  5321, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Marine Bio-products Technology

  DF10, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Marine Bio-products Technology

  DF10, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Marine Bioresource Science II

  5367, Fall, Faculty of Agriculture, 6
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Marine Bioresource Science I

  5365, Spring, Faculty of Agriculture, 6
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Technology of Marine Bio-products

  DG10, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Technology of Marine Bio-products

  DG10, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Marine Bio-production

  5301, Year-long, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Marine Biological Science

  5321, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Marine Bio-products Technology2

  DB47, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Marine Bio-products Technology1

  DB46, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Technology of Marine Bio-products2

  DC47, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Technology of Marine Bio-products1

  DC46, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Marine Biological Science

  5321, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Marine Bio-production

  5301, Year-long, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Marine Bio-products Technology1

  DB46, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Marine Bio-products Technology2

  DB47, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Technology of Marine Bio-products1

  DC46, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Foreign Literature in Bioresource Science II

  5189, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Technology of Marine Bio-products2

  DC47, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Marine Bio-production

  5301, Year-long, Faculty of Agriculture, 2
• From Apr. 2014, To Mar. 2015

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2014, To Mar. 2015

  Seminar in Marine Bio-products Technology

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Course in Technology of Marine Bio-products

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Technology of Marine Bio-products1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Technology of Marine Bio-products

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Seminar in Marine Bio-products Technology1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Seminar in Marine Bio-products Technology

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2015, To Mar. 2016

  Introduction to Foreign Literature in Bioresource Science I

  Spring, 農学部
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Technology of Marine Bio-products1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Technology of Marine Bio-products2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Technology of Marine Bio-products

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Marine Bio-products Technology1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Marine Bio-products Technology2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Marine Bio-products Technology

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2016, To Mar. 2017

  Introduction to Foreign Literature in Bioresource Science II

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Technology of Marine Bio-products1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Technology of Marine Bio-products2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Technology of Marine Bio-products

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Marine Bio-products Technology1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Marine Bio-products Technology2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Marine Bio-products Technology

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2017, To Mar. 2018

  Introduction to Foreign Literature in Bioresource Science II

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Technology of Marine Bio-products1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Technology of Marine Bio-products2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Seminar in Marine Bio-products Technology1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Seminar in Marine Bio-products Technology2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2018, To Mar. 2019

  Introduction to Foreign Literature in Bioresource Science II

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Technology of Marine Bio-products1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Technology of Marine Bio-products2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Seminar in Marine Bio-products Technology1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Seminar in Marine Bio-products Technology2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2019, To Mar. 2020

  Introduction to Foreign Literature in Bioresource Science I

  Spring, 農学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Technology of Marine Bio-products1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Technology of Marine Bio-products2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Seminar in Marine Bio-products Technology1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Seminar in Marine Bio-products Technology2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2020, To Mar. 2021

  Introduction to Foreign Literature in Bioresource Science I

  Spring, 農学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Technology of Marine Bio-products1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Technology of Marine Bio-products2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Seminar in Marine Bio-products Technology1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Seminar in Marine Bio-products Technology2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Seminar in Marine Bio-production

  Year-long, 農学部
• From Apr. 2021, To Mar. 2022

  Introduction to Foreign Literature in Bioresource Science I

  Spring, 農学部

Student achievements: Awards

• 優秀発表賞

  石原優花, 日本食品科学工学会関西支部, 26 Oct. 2019

Student achievements: Papers

• Evaluation of Intestinal Absorption of Dietary Halocynthiaxanthin, a Carotenoid from the Sea Squirt Halocynthia roretzi

  Chiaki Ikeda, Yuki Manabe, Nami Tomonaga, Tatsuya Wada, Takashi Maoka and Tatsuya Sugawara

  21 Nov. 2020, First author, Marine Drugs, 18, 12, 588, Peer-reviewed, English, Scientific journal, False

  https://doi.org/https://doi.org/10.3390/md18120588

Student achievements: Presentations

• 生体内異性化反応に着目したアロキサンチンの吸収動態の評価

  大久保 拓真、真鍋 祐樹、眞岡 孝至、菅原 達也

  第78回日本栄養・食糧学会大会, 25 May 2024, From 24 May 2024, To 26 May 2024, Not invited, Japanese, Oral presentation
• Evaluation of inhibitory effect of halocynthiaxanthin on differentiation into pro-inflammatory macrophages and its gastrointestinal absorption

  Chiaki Ikeda, Yuki Manabe, Nami Tomonaga, Tatsuya Wada, Takashi Maoka, Tatsuya Sugawara

  The International Symposium on Carotenoids, 09 Jul. 2023, From 09 Jul. 2023, To 14 Jul. 2023, Not invited, English, Poster presentation
• 紫外線障害から皮膚を保護するカロテノイドの探索

  涌田奈櫻、真鍋祐樹、毛利晋輔、菅原達也

  第77回日本栄養・食糧学会大会, 12 May 2023, From 12 May 2023, To 14 May 2023, Not invited, Japanese, Poster presentation
• 真皮線維芽細胞におけるカロテノイドの紫外線障害抑制作用

  涌田 奈櫻、真鍋 祐樹、毛利 晋輔、菅原 達也

  第34 回カロテノイド研究談話会, 18 Sep. 2022, From 17 Sep. 2022, To 18 Sep. 2022, Not invited, Japanese, Oral presentation
• 真皮線維芽細胞の紫外線障害に対するカロテノイドの保護効果

  涌田 奈櫻、真鍋 祐樹、毛利 晋輔、菅原 達也

  第76回日本栄養・食糧学会大会, 12 Jun. 2022, From 10 Jun. 2022, To 12 Jun. 2022, Not invited, Japanese, Oral presentation
• ミクログリアの炎症応答に対するシフォナキサンチンの抑制効果とその作用メカニズム

  上田 愛佳、真鍋 祐樹、毛利 晋輔、菅原 達也

  第76回日本栄養・食糧学会大会, 11 Jun. 2022, From 10 Jun. 2022, To 12 Jun. 2022, Not invited, Japanese, Oral presentation
• ミクログリアの炎症反応に対するカロテノイドの抑制効果

  上田愛佳、真鍋祐樹、毛利晋輔、菅原達也

  第60回 日本栄養・食糧学会 近畿支部大会, 27 Nov. 2021, From 27 Nov. 2021, To 27 Nov. 2021, Not invited, Japanese, Oral presentation
• 分子種に着目したプラズマローゲンの小腸上皮細胞への取り込みの評価

  石原優花、乙木百合香、仲川清隆、毛利晋輔、真鍋祐樹、菅原達也

  第60回 日本栄養・食糧学会 近畿支部大会, 27 Nov. 2021, From 27 Nov. 2021, To 27 Nov. 2021, Not invited, Japanese, Oral presentation
• 緑藻シフォナキサンチンの酸化的な代謝機構の解明

  清水亮佑、真鍋祐樹、菅原達也

  日本食品科学工学会 第４回関西支部大会, 13 Nov. 2021, From 13 Nov. 2021, To 13 Nov. 2021, Not invited, Japanese, Oral presentation
• シフォナキサンチンの代謝を担う酵素の探索

  清水 亮佑、真鍋 祐樹、菅原 達也

  第74回日本栄養・食糧学会大会 オンライン大会, 20 Sep. 2020, From 20 Sep. 2020, To 20 Sep. 2020, Not invited, Japanese, Oral presentation
• Bioactivities and Intestinal Absorption of Halocynthiaxanthin, a Carotenoid from Sea Squirts

  Chiaki Ikeda, Yuki Manabe, Nami Tomonaga, Takashi Maoka, Tatsuya Sugawara

  ICoFF2019/ISNFF2019, 01 Dec. 2019, From 01 Dec. 2019, To 05 Dec. 2019, Not invited, English, Poster presentation
• ハロシンチアキサンチンの消化管吸収

  池田千晶、真鍋祐樹、友永奈美、和田竜哉、眞岡孝至、菅原達也

  第58回日本栄養・食糧学会近畿支部大会, 16 Nov. 2019, From 16 Nov. 2019, To 16 Nov. 2019, Japanese, Oral presentation
• Caco-2細胞を用いたホヤ由来プラズマローゲンの消化管吸収の評価

  石原優花、仲川清隆、真鍋祐樹、菅原達也

  日本食品科学工学会関西支部大会, 26 Oct. 2019, From 26 Oct. 2019, To 26 Oct. 2019, Not invited, Japanese, Poster presentation
• マウスにおけるホヤカロテノイドの体内吸収動態

  池田千晶・友永奈美・真鍋祐樹・眞岡孝至・菅原達也

  第58回日本油化学会年会, 25 Sep. 2019, From 24 Sep. 2019, To 26 Sep. 2019, Not invited, Japanese, Oral presentation

Part-time lecturer

• From 01 Apr. 2020, To 31 Mar. 2023

  食品機能論

  前期, 京都府立大学, 生命環境学部食保健学科
• From 01 Apr. 2020, To 31 Mar. 2023

  生化学実験

  後期, 京都府立大学, 生命環境学部食保健学科

Administration

Faculty management (title, position)

• From 01 Apr. 2014, To 31 Mar. 2026

  動物実験委員会　委員
• From 01 Apr. 2016, To 31 Mar. 2018

  環境・安全・衛生委員会　委員