Basic Information

Affiliated programs (koza)

• Graduate School of Science, 生物科学専攻 霊長類学講座, 助教

Professional Memberships

• THE JAPAN NEUROSCIENCE SOCIETY
• Society for Neuroscience

Academic Degree

• 修士（生命科学）(東北大学)
• 博士（生命科学）(東北大学)

Research History

• From Oct. 2016, To Mar. 2020

  Japan Science and Technology Agency, Researcher
• From Oct. 2009, To Jun. 2013

  京都大学, 霊長類研究所, 特定助教
• From Apr. 2006, To Sep. 2009

  東京都神経科学総合研究所, 研究員
• From Apr. 2006, To Sep. 2009

  Japan Science and Technology Agency, CREST研究員
• From Apr. 2001, To Mar. 2006

  東北大学生命科学研究科, 修士課程・博士課程
• To Mar. 2001

  Kyoto University, Faculty of Science, 学士過程

Profile

• Profile

  ・Development of pathway/cell-type selective cell manipulation methods, and their application to studies on higher-order brain functions and pathogenesis and treatments in neurological and psychiatric disorders.
  ・Functional architecture of cortico-basal ganglia loop circuits and cortico-cerebellar loop circuits.

Language of Instruction

• English

ID,URL

• J-Global ID

  200901013049048370

• External link

  http://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/

Website(s) (URL(s))

• http://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/

researchmap URL

• https://researchmap.jp/dino

Research

Research Topics, Overview of the research

• Research Topics

  Development of pathway/cell-type selective cell manipulation methods, as well as their application to studies on higher-order brain functions, and on pathogenesis and treatments in neurological and psychiatric disorders.
  Functional architecture of cortico-basal ganglia loop circuits and cortico-cerebellar loop circuits.
  

• Overview of the research

  By developing novel techniques for investigating the mechanism of brain functions, we are conducting to elucidate the structure and function of neural networks surrounding the basal ganglia. The striatum, the input region of the basal ganglia, receives a complex inputs from cerebral cortex, thalamus and substantia nigra. Although abnormalities in the function of the striatum have long been examined in motor disorders such as Parkinson's disease, in recent years, abnormalities in the neurotransmission within striatum have been noted in many mental disorders. The striatal network that accounts for the development of these diverse disease states has not been clarified. We are attempting to analyze the input and output structure of the basal ganglia using various viral vectors, and to elucidate the mechanisms of higher brain functions of the cortico-basal ganglia loop circuits by examining the functional roles of individual projection systems. We are also working on the elucidation of the pathophysiology of psychiatric and neurological diseases, as well as the development of new therapies, by creating animal models of such diseases.

Research Areas

• Life sciences, Neuroscience - general
• Life sciences, Neuroanatomy and physiology

Papers

• Functional heterogeneity within the primate ventral striatum for motivational regulation.

  Haruhiko Iwaoki; Yukiko Hori; Yuki Hori; Koki Mimura; Kei Oyama; Yuji Nagai; Toshiyuki Hirabayashi; Ken-Ichi Inoue; Masahiko Takada; Makoto Higuchi; Takafumi Minamimoto

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 14 Apr. 2025

  
• Longitudinal assessment of DREADD expression and efficacy in the monkey brain

  Yuji Nagai; Yukiko Hori; Ken-ichi Inoue; Toshiyuki Hirabayashi; Koki Mimura; Kei Oyama; Naohisa Miyakawa; Yuki Hori; Haruhiko Iwaoki; Katsushi Kumata; Ming-Rong Zhang; Masahiko Takada; Makoto Higuchi; Takafumi Minamimoto

  02 Apr. 2025

  
• Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations

  Gaoge Yan; Hidetoshi Amita; Satoshi Nonomura; Ken-ichi Inoue; Wolfram Schultz; Masahiko Takada

  Proceedings of the National Academy of Sciences, 18 Mar. 2025

  
• Scg2 drives reorganization of the corticospinal circuit with spinal premotor interneurons to recover motor function after stroke

  Tokiharu Sato; Yuka Nakamura; Kana Hoshina; Ken-ichi Inoue; Masahiko Takada; Masato Yano; Hitoshi Matsuzawa; Masaki Ueno

  22 Jan. 2025

  
• Bidirectional Optogenetic Modulations of Peripheral Sensory Nerve Activity: Induction vs. Suppression through Channelrhodopsin and Halorhodopsin

  Akito Kosugi; Ken-ichi Inoue; Masahiko Takada; Kazuhiko Seki

  19 Aug. 2024

  
• Distinct roles of two thalamostriatal systems in learning processes of visual discrimination in common marmosets

  Shigeki Kato; Masateru Sugawara; Miwako Yamasaki; Masahiko Watanabe; Ken-ichi Inoue; Katsuki Nakamura; Daisuke Koketsu; Satomi Chiken; Atsushi Nambu; Masahiko Takada; Kazuto Kobayashi

  06 Jun. 2024

  
• Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior

  Ken-ichi Inoue

  Cell Reports Methods, 2024

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• Analysis of multisynaptic neuronal pathways by using rabies virus

  Takada, M.; Inoue, K.-I.; Miyachi, S.

  Brain and Nerve, 2010

  
• Prevention of Calbindin Recruitment into Nigral Dopamine Neurons from MPTP-Induced Degeneration in Macaca fascicularis

  Takada, Masahiko; Inoue, Ken-ichi; Miyachi, Shigehiro; Okado, Haruo; Nambu, Atsushi; Groenewegen, HJ; Berendse, HW; Cools, AR; Voorn, P.; Mulder, AB

  Basal Ganglia Ix, 2009

  
• Movement-independent representation of reward-predicting cues in the medial part of the primate premotor cortex

  Keisuke Sehara; Masashi Kondo; Yuka Hirayama; Teppei Ebina; Masafumi Takaji; Akiya Watakabe; Ken-ichi Inoue; Masahiko Takada; Tetsuo Yamamori; Masanori Matsuzaki

  26 Aug. 2024

  
• Multiscale chemogenetic dissection of fronto-temporal top-down regulation for object memory in primates.

  Toshiyuki Hirabayashi; Yuji Nagai; Yuki Hori; Yukiko Hori; Kei Oyama; Koki Mimura; Naohisa Miyakawa; Haruhiko Iwaoki; Ken-Ichi Inoue; Tetsuya Suhara; Masahiko Takada; Makoto Higuchi; Takafumi Minamimoto

  Nature communications, 10 Jul. 2024

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• Deciphering social traits and pathophysiological conditions from natural behaviors in common marmosets.

  Takaaki Kaneko; Jumpei Matsumoto; Wanyi Lu; Xincheng Zhao; Louie Richard Ueno-Nigh; Takao Oishi; Kei Kimura; Yukiko Otsuka; Andi Zheng; Kensuke Ikenaka; Kousuke Baba; Hideki Mochizuki; Hisao Nishijo; Ken-Ichi Inoue; Masahiko Takada

  Current biology : CB, 08 Jul. 2024

  
• Distinct roles of monkey OFC-subcortical pathways in adaptive behavior

  Kei Oyama; Kei Majima; Yuji Nagai; Yukiko Hori; Toshiyuki Hirabayashi; Mark A G Eldridge; Koki Mimura; Naohisa Miyakawa; Atsushi Fujimoto; Yuki Hori; Haruhiko Iwaoki; Ken-ichi Inoue; Richard C Saunders; Masahiko Takada; Noriaki Yahata; Makoto Higuchi; Barry J Richmond; Takafumi Minamimoto

  17 Nov. 2023

  
• Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates.

  Yuki Hori; Yuji Nagai; Yukiko Hori; Kei Oyama; Koki Mimura; Toshiyuki Hirabayashi; Ken-Ichi Inoue; Masayuki Fujinaga; Ming-Rong Zhang; Masahiko Takada; Makoto Higuchi; Takafumi Minamimoto

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 27 Sep. 2023

  
• Three-dimensional markerless motion capture of multiple freely behaving monkeys for automated characterization of social behavior

  Jumpei Matsumoto; Takaaki Kaneko; Kei Kimura; Salvador Blanco Negrete; Jia Guo; Naoko Suda-Hashimoto; Akihisa Kaneko; Mayumi Morimoto; Hiroshi Nishimaru; Tsuyoshi Setogawa; Yasuhiro Go; Tomohiro Shibata; Hisao Nishijo; Masahiko Takada; Ken-ichi Inoue

  bioRxiv, 13 Sep. 2023

  
• A mosaic adeno-associated virus vector as a versatile tool that exhibits high levels of transgene expression and neuron specificity in primate brain.

  Kei Kimura; Yuji Nagai; Gaku Hatanaka; Yang Fang; Soshi Tanabe; Andi Zheng; Maki Fujiwara; Mayuko Nakano; Yukiko Hori; Ryosuke F Takeuchi; Mikio Inagaki; Takafumi Minamimoto; Ichiro Fujita; Ken-Ichi Inoue; Masahiko Takada

  Nature communications, 08 Aug. 2023

  
• A light-gated cation channel with high reactivity to weak light.

  Shoko Hososhima; Shinji Ueno; Satoshi Okado; Ken-Ichi Inoue; Masae Konno; Yumeka Yamauchi; Keiichi Inoue; Hiroko Terasaki; Hideki Kandori; Satoshi P Tsunoda

  Scientific reports, 10 May 2023

  
• BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: Targeted AAV vector delivery and PET imaging.

  Javier Blesa; José A Pineda-Pardo; Ken-Ichi Inoue; Carmen Gasca-Salas; Tiziano Balzano; Natalia López-González Del Rey; Alejandro Reinares-Sebastián; Noelia Esteban-García; Rafael Rodríguez-Rojas; Raquel Márquez; María Ciorraga; Marta Del Álamo; Lina García-Cañamaque; Santiago Ruiz de Aguiar; Itay Rachmilevitch; Inés Trigo-Damas; Masahiko Takada; José A Obeso

  Science advances, 21 Apr. 2023

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• Environmental context-dependent activation of dopamine neurons via putative amygdala-nigra pathway in macaques.

  Kazutaka Maeda; Ken-Ichi Inoue; Masahiko Takada; Okihide Hikosaka

  Nature communications, 21 Apr. 2023

  
• Diurnal variation in declarative memory and the involvement of SCOP in cognitive functions in nonhuman primates.

  Kimiko Shimizu; Ken-Ichi Inoue; Takao Oishi; Masahiko Takada; Yoshitaka Fukada; Hiroo Imai

  Molecular brain, 25 Mar. 2023

  
• Chemogenetic attenuation of cortical seizures in nonhuman primates.

  Naohisa Miyakawa; Yuji Nagai; Yukiko Hori; Koki Mimura; Asumi Orihara; Kei Oyama; Takeshi Matsuo; Ken-Ichi Inoue; Takafumi Suzuki; Toshiyuki Hirabayashi; Tetsuya Suhara; Masahiko Takada; Makoto Higuchi; Keisuke Kawasaki; Takafumi Minamimoto

  Nature communications, 28 Feb. 2023

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• Gene expression profiling of the masticatory muscle tendons and Achilles tendons under tensile strain in the Japanese macaque Macaca fuscata.

  Ko Ito; Yasuhiro Go; Shoji Tatsumoto; Chika Usui; Yosuke Mizuno; Eiji Ikami; Yuta Isozaki; Michihiko Usui; Takeshi Kajihara; Tetsuya Yoda; Ken-Ichi Inoue; Masahiko Takada; Tsuyoshi Sato

  PloS one, 2023, Peer-reviewed

  
• Establishment of mouse model of inherited PIGO deficiency and therapeutic potential of AAV-based gene therapy

  Ryoko Kuwayama; Keiichiro Suzuki; Jun Nakamura; Emi Aizawa; Yoshichika Yoshioka; Masahito Ikawa; Shin Nabatame; Ken-ichi Inoue; Yoshiari Shimmyo; Keiichi Ozono; Taroh Kinoshita; Yoshiko Murakami

  Nature Communications, Dec. 2022

  
• A calcitonin receptor-expressing subregion of the medial preoptic area is involved in alloparental tolerance in common marmosets.

  Kazutaka Shinozuka; Saori Yano-Nashimoto; Chihiro Yoshihara; Kenichi Tokita; Takuma Kurachi; Ryosuke Matsui; Dai Watanabe; Ken-Ichi Inoue; Masahiko Takada; Keiko Moriya-Ito; Hironobu Tokuno; Michael Numan; Atsuko Saito; Kumi O Kuroda

  Communications biology, 21 Nov. 2022

  
• Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action.

  Kei Oyama; Yukiko Hori; Koki Mimura; Yuji Nagai; Mark A G Eldridge; Richard C Saunders; Naohisa Miyakawa; Toshiyuki Hirabayashi; Yuki Hori; Ken-Ichi Inoue; Tetsuya Suhara; Masahiko Takada; Makoto Higuchi; Barry J Richmond; Takafumi Minamimoto

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 01 Jul. 2022

  
• Perturbation of monoamine metabolism and enhanced fear responses in mice defective in the regeneration of tetrahydrobiopterin.

  Katsuya Miyajima; Yusuke Sudo; Sho Sanechika; Yoshitaka Hara; Mieko Horiguchi; Feng Xu; Minori Suzuki; Satoshi Hara; Koichi Tanda; Ken-Ichi Inoue; Masahiko Takada; Nozomu Yoshioka; Hirohide Takebayashi; Masayo Mori-Kojima; Masahiro Sugimoto; Chiho Sumi-Ichinose; Kazunao Kondo; Keizo Takao; Tsuyoshi Miyakawa; Hiroshi Ichinose

  Journal of neurochemistry, Apr. 2022

  
• A multisynaptic pathway from the ventral midbrain toward spinal motoneurons in monkeys.

  Michiaki Suzuki; Ken-Ichi Inoue; Hiroshi Nakagawa; Hiroaki Ishida; Kenta Kobayashi; Tadashi Isa; Masahiko Takada; Yukio Nishimura

  The Journal of physiology, Apr. 2022

  
• Chronic Behavioral Manipulation via Orally Delivered Chemogenetic Actuator in Macaques.

  Kei Oyama; Yukiko Hori; Yuji Nagai; Naohisa Miyakawa; Koki Mimura; Toshiyuki Hirabayashi; Ken-Ichi Inoue; Masahiko Takada; Makoto Higuchi; Takafumi Minamimoto

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 Mar. 2022

  
• Rapid processing of threatening faces in the amygdala of nonhuman primates: subcortical inputs and dual roles

  Mikio Inagaki; Ken-ichi Inoue; Soshi Tanabe; Kei Kimura; Masahiko Takada; Ichiro Fujita

  Cerebral Cortex, 22 Mar. 2022

  
• Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.

  Misaki Niu; Atsushi Kasai; Masato Tanuma; Kaoru Seiriki; Hisato Igarashi; Takahiro Kuwaki; Kazuki Nagayasu; Keita Miyaji; Hiroki Ueno; Wataru Tanabe; Kei Seo; Rei Yokoyama; Jin Ohkubo; Yukio Ago; Misuzu Hayashida; Ken-Ichi Inoue; Masahiko Takada; Shun Yamaguchi; Takanobu Nakazawa; Shuji Kaneko; Hiroyuki Okuno; Akihiro Yamanaka; Hitoshi Hashimoto

  Science advances, 18 Mar. 2022

  
• Conservation of the Direct and Indirect Pathway Dichotomy in Mouse Caudal Striatum With Uneven Distribution of Dopamine Receptor D1- and D2-Expressing Neurons

  Kumiko Ogata; Fuko Kadono; Yasuharu Hirai; Ken-ichi Inoue; Masahiko Takada; Fuyuki Karube; Fumino Fujiyama

  Frontiers in Neuroanatomy, 04 Feb. 2022, Peer-reviewed

  
• Origin of Multisynaptic Corticospinal Pathway to Forelimb Segments in Macaques and Its Reorganization After Spinal Cord Injury.

  Taihei Ninomiya; Hiroshi Nakagawa; Ken-Ichi Inoue; Yukio Nishimura; Takao Oishi; Toshihide Yamashita; Masahiko Takada

  Frontiers in neural circuits, 2022

  
• Laminar Organization of the Entorhinal Cortex in Macaque Monkeys Based on Cell-Type-Specific Markers and Connectivity

  Shinya Ohara; Rintaro Yoshino; Kei Kimura; Taichi Kawamura; Soshi Tanabe; Andi Zheng; Shinya Nakamura; Ken-ichi Inoue; Masahiko Takada; Ken-Ichiro Tsutsui; Menno P. Witter

  Frontiers in Neural Circuits, 07 Dec. 2021

  
• Specific gene expression in unmyelinated dorsal root ganglion neurons in nonhuman primates by intra-nerve injection of AAV 6 vector

  Moeko Kudo; Sidikejiang Wupuer; Maki Fujiwara; Yuko Saito; Shinji Kubota; Ken-ichi Inoue; Masahiko Takada; Kazuhiko Seki

  Molecular Therapy - Methods & Clinical Development, Dec. 2021

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• Chemogenetic sensory fMRI reveals behaviorally relevant bidirectional changes in primate somatosensory network.

  Toshiyuki Hirabayashi; Yuji Nagai; Yukiko Hori; Ken-Ichi Inoue; Ichio Aoki; Masahiko Takada; Tetsuya Suhara; Makoto Higuchi; Takafumi Minamimoto

  Neuron, 20 Oct. 2021

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• Chemogenetic activation of nigrostriatal dopamine neurons in freely moving common marmosets.

  Koki Mimura; Yuji Nagai; Ken-Ichi Inoue; Jumpei Matsumoto; Yukiko Hori; Chika Sato; Kei Kimura; Takashi Okauchi; Toshiyuki Hirabayashi; Hisao Nishijo; Noriaki Yahata; Masahiko Takada; Tetsuya Suhara; Makoto Higuchi; Takafumi Minamimoto

  iScience, 24 Sep. 2021

  
• Microendoscopic calcium imaging of the primary visual cortex of behaving macaques.

  Mineki Oguchi; Jiang Jiasen; Toshihide W Yoshioka; Yasuhiro R Tanaka; Kenichi Inoue; Masahiko Takada; Takefumi Kikusui; Kensaku Nomoto; Masamichi Sakagami

  Scientific reports, 23 Aug. 2021, Peer-reviewed

  
• Single caudate neurons encode temporally discounted value for formulating motivation for action

  Yukiko Hori; Koki Mimura; Yuji Nagai; Atsushi Fujimoto; Kei Oyama; Erika Kikuchi; Ken-ichi Inoue; Masahiko Takada; Tetsuya Suhara; Barry J Richmond; Takafumi Minamimoto

  eLife, 30 Jul. 2021

  
• Retrograde Transgene Expression via Neuron-Specific Lentiviral Vector Depends on Both Species and Input Projections

  Yukiko Otsuka; Hitomi Tsuge; Shiori Uezono; Soshi Tanabe; Maki Fujiwara; Miki Miwa; Shigeki Kato; Katsuki Nakamura; Kazuto Kobayashi; Ken-ichi Inoue; Masahiko Takada

  Viruses, 16 Jul. 2021

  
• Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making.

  Kei Oyama; Yukiko Hori; Yuji Nagai; Naohisa Miyakawa; Koki Mimura; Toshiyuki Hirabayashi; Ken-Ichi Inoue; Tetsuya Suhara; Masahiko Takada; Makoto Higuchi; Takafumi Minamimoto

  Science advances, Jun. 2021, Peer-reviewed

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• Effects of Optogenetic Suppression of Cortical Input on Primate Thalamic Neuronal Activity during Goal-Directed Behavior.

  Tomoki W Suzuki; Ken-Ichi Inoue; Masahiko Takada; Masaki Tanaka

  eNeuro, Mar. 2021, Peer-reviewed

  
• Nonhuman Primate Optogenetics: Current Status and Future Prospects.

  Ken-Ichi Inoue; Masayuki Matsumoto; Masahiko Takada

  Advances in experimental medicine and biology, Mar. 2021, Peer-reviewed, Lead author, Corresponding author

  
• MacaquePose: A Novel "In the Wild" Macaque Monkey Pose Dataset for Markerless Motion Capture.

  Rollyn Labuguen; Jumpei Matsumoto; Salvador Blanco Negrete; Hiroshi Nishimaru; Hisao Nishijo; Masahiko Takada; Yasuhiro Go; Ken-Ichi Inoue; Tomohiro Shibata

  Frontiers in behavioral neuroscience, Jan. 2021, Peer-reviewed

  
• An Open Resource for Non-human Primate Optogenetics.

  Sébastien Tremblay; Leah Acker; Arash Afraz; Daniel L Albaugh; Hidetoshi Amita; Ariana R Andrei; Alessandra Angelucci; Amir Aschner; Puiu F Balan; Michele A Basso; Giacomo Benvenuti; Martin O Bohlen; Michael J Caiola; Roberto Calcedo; James Cavanaugh; Yuzhi Chen; Spencer Chen; Mykyta M Chernov; Andrew M Clark; Ji Dai; Samantha R Debes; Karl Deisseroth; Robert Desimone; Valentin Dragoi; Seth W Egger; Mark A G Eldridge; Hala G El-Nahal; Francesco Fabbrini; Frederick Federer; Christopher R Fetsch; Michal G Fortuna; Robert M Friedman; Naotaka Fujii; Alexander Gail; Adriana Galvan; Supriya Ghosh; Marc Alwin Gieselmann; Roberto A Gulli; Okihide Hikosaka; Eghbal A Hosseini; Xing Hu; Janina Hüer; Ken-Ichi Inoue; Roger Janz; Mehrdad Jazayeri; Rundong Jiang; Niansheng Ju; Kohitij Kar; Carsten Klein; Adam Kohn; Misako Komatsu; Kazutaka Maeda; Julio C Martinez-Trujillo; Masayuki Matsumoto; John H R Maunsell; Diego Mendoza-Halliday; Ilya E Monosov; Ross S Muers; Lauri Nurminen; Michael Ortiz-Rios; Daniel J O'Shea; Stéphane Palfi; Christopher I Petkov; Sorin Pojoga; Rishi Rajalingham; Charu Ramakrishnan; Evan D Remington; Cambria Revsine; Anna W Roe; Philip N Sabes; Richard C Saunders; Hansjörg Scherberger; Michael C Schmid; Wolfram Schultz; Eyal Seidemann; Yann-Suhan Senova; Michael N Shadlen; David L Sheinberg; Caitlin Siu; Yoland Smith; Selina S Solomon; Marc A Sommer; John L Spudich; William R Stauffer; Masahiko Takada; Shiming Tang; Alexander Thiele; Stefan Treue; Wim Vanduffel; Rufin Vogels; Matthew P Whitmire; Thomas Wichmann; Robert H Wurtz; Haoran Xu; Azadeh Yazdan-Shahmorad; Krishna V Shenoy; James J DiCarlo; Michael L Platt

  Neuron, 23 Dec. 2020, Peer-reviewed

  
• Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys.

  Yuji Nagai; Naohisa Miyakawa; Hiroyuki Takuwa; Yukiko Hori; Kei Oyama; Bin Ji; Manami Takahashi; Xi-Ping Huang; Samuel T Slocum; Jeffrey F DiBerto; Yan Xiong; Takuya Urushihata; Toshiyuki Hirabayashi; Atsushi Fujimoto; Koki Mimura; Justin G English; Jing Liu; Ken-Ichi Inoue; Katsushi Kumata; Chie Seki; Maiko Ono; Masafumi Shimojo; Ming-Rong Zhang; Yutaka Tomita; Jin Nakahara; Tetsuya Suhara; Masahiko Takada; Makoto Higuchi; Jian Jin; Bryan L Roth; Takafumi Minamimoto

  Nature neuroscience, 06 Jul. 2020, Peer-reviewed

  
• Primate Amygdalo-Nigral Pathway for Boosting Oculomotor Action in Motivating Situations.

  Kazutaka Maeda; Ken-Ichi Inoue; Jun Kunimatsu; Masahiko Takada; Okihide Hikosaka

  iScience, 26 Jun. 2020, Peer-reviewed

  
• New Cerebello-Cortical Pathway Involved in Higher-Order Oculomotor Control.

  Xiaofeng Lu; Ken-Ichi Inoue; Shogo Ohmae; Yusuke Uchida

  Cerebellum (London, England), Jun. 2020, Peer-reviewed

  
• Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift.

  Hidetoshi Amita; Hyoung F Kim; Ken-Ichi Inoue; Masahiko Takada; Okihide Hikosaka

  Nature communications, 20 Apr. 2020, Peer-reviewed

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• Layer specificity of inputs from supplementary motor area and dorsal premotor cortex to primary motor cortex in macaque monkeys.

  Taihei Ninomiya; Ken-Ichi Inoue; Eiji Hoshi; Masahiko Takada

  Scientific reports, 03 Dec. 2019, Peer-reviewed

  
• Identification of neuron-type specific promoters in monkey genome and their functional validation in mice.

  Yuma Nagai; Naoya Nishitani; Masaharu Yasuda; Yasumasa Ueda; Yuto Fukui; Chihiro Andoh; Hisashi Shirakawa; Takayuki Nakagawa; Ken-Ichi Inoue; Kazuki Nagayasu; Sergey Kasparov; Kae Nakamura; Shuji Kaneko

  Biochemical and biophysical research communications, 22 Oct. 2019, Peer-reviewed

  
• Optogenetic recruitment of spinal reflex pathways from large-diameter primary afferents in non-transgenic rats transduced with AAV9/Channelrhodopsin 2.

  Shinji Kubota; Wupuer Sidikejiang; Moeko Kudo; Ken-Ichi Inoue; Tatsuya Umeda; Masahiko Takada; Kazuhiko Seki

  The Journal of physiology, Oct. 2019, Peer-reviewed

  
• A note on retrograde gene transfer efficiency and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins.

  Soshi Tanabe; Shiori Uezono; Hitomi Tsuge; Maki Fujiwara; Miki Miwa; Shigeki Kato; Katsuki Nakamura; Kazuto Kobayashi; Ken-Ichi Inoue; Masahiko Takada

  Scientific reports, 05 Mar. 2019, Peer-reviewed, Corresponding author

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• Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism.

  Ken-Ichi Inoue; Shigehiro Miyachi; Katsunori Nishi; Haruo Okado; Yuji Nagai; Takafumi Minamimoto; Atsushi Nambu; Masahiko Takada

  Movement disorders : official journal of the Movement Disorder Society, Feb. 2019, Peer-reviewed, Lead author

  
• Enhancement of the transduction efficiency of a lentiviral vector for neuron-specific retrograde gene delivery through the point mutation of fusion glycoprotein type E.

  Shigeki Kato; Masateru Sugawara; Kenta Kobayashi; Kei Kimura; Ken-Ichi Inoue; Masahiko Takada; Kazuto Kobayashi

  Journal of neuroscience methods, 01 Jan. 2019, Peer-reviewed

  
• Causal Role of Neural Signals Transmitted From the Frontal Eye Field to the Superior Colliculus in Saccade Generation.

  Masayuki Matsumoto; Ken-Ichi Inoue; Masahiko Takada

  Frontiers in neural circuits, Aug. 2018, Peer-reviewed

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• Segmentation of the rabies virus genome.

  Yuya Hidaka; Chang-Kweng Lim; Mutsuyo Takayama-Ito; Chun-Ho Park; Kazunori Kimitsuki; Nozomi Shiwa; Ken-Ichi Inoue; Takuya Itou

  Virus research, 02 Jul. 2018, Peer-reviewed

  
• Alterations in the reduced pteridine contents in the cerebrospinal fluids of LRRK2 mutation carriers and patients with Parkinson's disease.

  Hiroshi Ichinose; Ken-Ichi Inoue; Shinobu Arakawa; Yuki Watanabe; Hiroki Kurosaki; Shoko Koshiba; Eldbjorg Hustad; Masahiko Takada; Jan O Aasly

  Journal of neural transmission (Vienna, Austria : 1996), Jan. 2018, Peer-reviewed

  
• Multisynaptic Projections from the Amygdala to the Ventral Premotor Cortex in Macaque Monkeys: Anatomical Substrate for Feeding Behavior.

  Hiroaki Ishida; Ken-Ichi Inoue; Masahiko Takada

  Frontiers in neuroanatomy, Jan. 2018, Peer-reviewed, Lead author

  
• Nonhuman Primate Optogenetics: Recent Advances and Future Directions.

  Adriana Galvan; William R Stauffer; Leah Acker; Yasmine El-Shamayleh; Ken-Ichi Inoue; Shay Ohayon; Michael C Schmid

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 08 Nov. 2017, Peer-reviewed

  
• Pseudotyped Lentiviral Vectors for Retrograde Gene Delivery into Target Brain Regions.

  Kenta Kobayashi; Ken-Ichi Inoue; Soshi Tanabe; Shigeki Kato; Masahiko Takada; Kazuto Kobayashi

  Frontiers in neuroanatomy, Aug. 2017, Peer-reviewed

  
• The use of an optimized chimeric envelope glycoprotein enhances the efficiency of retrograde gene transfer of a pseudotyped lentiviral vector in the primate brain.

  Soshi Tanabe; Ken-Ichi Inoue; Hitomi Tsuge; Shiori Uezono; Kiyomi Nagaya; Maki Fujiwara; Shigeki Kato; Kazuto Kobayashi; Masahiko Takada

  Neuroscience research, Jul. 2017, Peer-reviewed, Lead author, Corresponding author

  
• High-Speed and Scalable Whole-Brain Imaging in Rodents and Primates.

  Kaoru Seiriki; Atsushi Kasai; Takeshi Hashimoto; Wiebke Schulze; Misaki Niu; Shun Yamaguchi; Takanobu Nakazawa; Ken-Ichi Inoue; Shiori Uezono; Masahiko Takada; Yuichiro Naka; Hisato Igarashi; Masato Tanuma; James A Waschek; Yukio Ago; Kenji F Tanaka; Atsuko Hayata-Takano; Kazuki Nagayasu; Norihito Shintani; Ryota Hashimoto; Yasuto Kunii; Mizuki Hino; Junya Matsumoto; Hirooki Yabe; Takeharu Nagai; Katsumasa Fujita; Toshio Matsuda; Kazuhiro Takuma; Akemichi Baba; Hitoshi Hashimoto

  Neuron, 21 Jun. 2017, Peer-reviewed

  
• Visuomotor signals for reaching movements in the rostro-dorsal sector of the monkey thalamic reticular nucleus.

  Yosuke Saga; Yoshihisa Nakayama; Ken-Ichi Inoue; Tomoko Yamagata; Masashi Hashimoto; Léon Tremblay; Masahiko Takada; Eiji Hoshi

  The European journal of neuroscience, May 2017, Peer-reviewed

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• PET imaging-guided chemogenetic silencing reveals a critical role of primate rostromedial caudate in reward evaluation.

  Yuji Nagai; Erika Kikuchi; Walter Lerchner; Ken-Ichi Inoue; Bin Ji; Mark A G Eldridge; Hiroyuki Kaneko; Yasuyuki Kimura; Arata Oh-Nishi; Yukiko Hori; Yoko Kato; Toshiyuki Hirabayashi; Atsushi Fujimoto; Katsushi Kumata; Ming-Rong Zhang; Ichio Aoki; Tetsuya Suhara; Makoto Higuchi; Masahiko Takada; Barry J Richmond; Takafumi Minamimoto

  Nature communications, 06 Dec. 2016, Peer-reviewed

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• Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques.

  Katsuo Kimura; Ken-Ichi Inoue; Yoshiyuki Kuroiwa; Fumiaki Tanaka; Masahiko Takada

  PloS one, Nov. 2016, Peer-reviewed

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• Origins of multisynaptic projections from the basal ganglia to the forelimb region of the ventral premotor cortex in macaque monkeys.

  Hiroaki Ishida; Ken-ichi Inoue; Masahiko Takada; Eiji Hoshi

  The European journal of neuroscience, Jan. 2016, Peer-reviewed, Lead author

  
• Altering Entry Site Preference of Lentiviral Vectors into Neuronal Cells by Pseudotyping with Envelope Glycoproteins.

  Kenta Kobayashi; Shigeki Kato; Ken-Ichi Inoue; Masahiko Takada; Kazuto Kobayashi

  Methods in molecular biology (Clifton, N.J.), 2016, Peer-reviewed

  
• Distribution of glutamatergic, GABAergic, and glycinergic neurons in the auditory pathways of macaque monkeys.

  T Ito; K Inoue; M Takada

  Neuroscience, 03 Dec. 2015, Peer-reviewed

  
• Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system.

  Ken-Ichi Inoue; Masahiko Takada; Masayuki Matsumoto

  Nature communications, 21 Sep. 2015, Peer-reviewed, Lead author

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• Morphological study of the accommodative apparatus in the monkey eye.

  Mari Hiraoka; Kenichi Inoue; Haruki Senoo; Masahiko Takada

  Anatomical record (Hoboken, N.J. : 2007), Mar. 2015, Peer-reviewed

  
• Dorsal area 46 is a major target of disynaptic projections from the medial temporal lobe.

  Yoshihiro Hirata; Shigehiro Miyachi; Ken-ichi Inoue; Taihei Ninomiya; Daisuke Takahara; Eiji Hoshi; Masahiko Takada

  Cerebral cortex (New York, N.Y. : 1991), Dec. 2013, Peer-reviewed

  
• Elucidating information processing in primate basal ganglia circuitry: a novel technique for pathway-selective ablation mediated by immunotoxin.

  Masahiko Takada; Ken-Ichi Inoue; Daisuke Koketsu; Shigeki Kato; Kazuto Kobayashi; Atsushi Nambu

  Frontiers in neural circuits, Sep. 2013, Peer-reviewed

  
• Multisynaptic projections from the ventrolateral prefrontal cortex to hand and mouth representations of the monkey primary motor cortex.

  Shigehiro Miyachi; Yoshihiro Hirata; Ken-ichi Inoue; Xiaofeng Lu; Atsushi Nambu; Masahiko Takada

  Neuroscience research, Jul. 2013, Peer-reviewed

  
• Efficient in vivo depletion of CD8(+) T lymphocytes in common marmosets by novel CD8 monoclonal antibody administration

  Tomoyuki Yoshida; Saori Suzuki; Yuki Iwasaki; Akihisa Kaneko; Akatsuki Saito; Yuki Enomoto; Atsunori Higashino; Akino Watanabe; Juri Suzuki; Kenichi Inoue; Teiko Kuroda; Masahiko Takada; Ryoji Ito; Mamoru Ito; Hirofumi Akari

  IMMUNOLOGY LETTERS, Jul. 2013, Peer-reviewed

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• Developmental anatomy in the zonular connection with lens capsule in macaque eye.

  Mari Hiraoka; Teiko Kuroda; Kenichi Inoue; Haruki Senoo; Masahiko Takada

  Anatomical record (Hoboken, N.J. : 2007), May 2013, Peer-reviewed

  
• Multisynaptic inputs from the medial temporal lobe to V4 in macaques.

  Taihei Ninomiya; Hiromasa Sawamura; Ken-Ichi Inoue; Masahiko Takada

  PloS one, Dec. 2012, Peer-reviewed

  
• Multisynaptic projections from the ventrolateral prefrontal cortex to the dorsal premotor cortex in macaques - anatomical substrate for conditional visuomotor behavior.

  Daisuke Takahara; Ken-Ichi Inoue; Yoshihiro Hirata; Shigehiro Miyachi; Atsushi Nambu; Masahiko Takada; Eiji Hoshi

  The European journal of neuroscience, Nov. 2012, Peer-reviewed

  
• Immunotoxin-mediated tract targeting in the primate brain: selective elimination of the cortico-subthalamic "hyperdirect" pathway.

  Ken-ichi Inoue; Daisuke Koketsu; Shigeki Kato; Kazuto Kobayashi; Atsushi Nambu; Masahiko Takada

  PloS one, Jun. 2012, Peer-reviewed, Lead author

  
• Segregated pathways carrying frontally derived top-down signals to visual areas MT and V4 in macaques.

  Taihei Ninomiya; Hiromasa Sawamura; Ken-Ichi Inoue; Masahiko Takada

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 16 May 2012, Peer-reviewed

  
• Ischaemia in the Zinn-Haller circle and glaucomatous optic neuropathy in macaque monkeys.

  Mari Hiraoka; Kenichi Inoue; Taihei Ninomiya; Masahiko Takada

  The British journal of ophthalmology, Apr. 2012, Peer-reviewed

  
• Localization of papillofoveal bundles in primates.

  Mari Hiraoka; Kenichi Inoue; Hitoshi Kawano; Masahiko Takada

  Anatomical record (Hoboken, N.J. : 2007), Feb. 2012, Peer-reviewed

  
• Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein.

  Shigeki Kato; Masahito Kuramochi; Kenji Takasumi; Kenta Kobayashi; Ken-ichi Inoue; Daisuke Takahara; Seiji Hitoshi; Kazuhiro Ikenaka; Takashi Shimada; Masahiko Takada; Kazuto Kobayashi

  Human gene therapy, Dec. 2011, Peer-reviewed

  
• Differential architecture of multisynaptic geniculo-cortical pathways to V4 and MT.

  Taihei Ninomiya; Hiromasa Sawamura; Ken-ichi Inoue; Masahiko Takada

  Cerebral cortex (New York, N.Y. : 1991), Dec. 2011, Peer-reviewed

  
• A lentiviral strategy for highly efficient retrograde gene transfer by pseudotyping with fusion envelope glycoprotein.

  Shigeki Kato; Kenta Kobayashi; Ken-ichi Inoue; Masahito Kuramochi; Tomoaki Okada; Hiroyuki Yaginuma; Kinjiro Morimoto; Takashi Shimada; Masahiko Takada; Kazuto Kobayashi

  Human gene therapy, Feb. 2011, Peer-reviewed

  
• Origins of multisynaptic projections from the basal ganglia to rostrocaudally distinct sectors of the dorsal premotor area in macaques.

  Yosuke Saga; Yoshihiro Hirata; Daisuke Takahara; Ken-Ichi Inoue; Shigehiro Miyachi; Atsushi Nambu; Jun Tanji; Masahiko Takada; Eiji Hoshi

  The European journal of neuroscience, Jan. 2011, Peer-reviewed, Lead author

  
• Intracapsular organization of ciliary zonules in monkey eyes.

  Mari Hiraoka; Ken-Ichi Inoue; Chiaki Ohtaka-Maruyama; Shunji Ohsako; Naosuke Kojima; Haruki Senoo; Masahiko Takada

  Anatomical record (Hoboken, N.J. : 2007), Oct. 2010, Peer-reviewed

  
• マカクザルの前頭葉から4次視覚野への多シナプス性入力様式(Multisynaptic inputs from the frontal lobe to V4 of macaques)

  二宮 太平; 澤村 裕正; 井上 謙一; 高田 昌彦

  神経化学, Aug. 2010

  
• Motor and non-motor projections from the cerebellum to rostrocaudally distinct sectors of the dorsal premotor cortex in macaques.

  Masashi Hashimoto; Daisuke Takahara; Yoshihiro Hirata; Ken-ichi Inoue; Shigehiro Miyachi; Atsushi Nambu; Jun Tanji; Masahiko Takada; Eiji Hoshi

  The European journal of neuroscience, Apr. 2010, Peer-reviewed, Lead author

  
• Untangling neural networks with dual retrograde transsynaptic viral infection.

  Shinya Ohara; Ken-Ichi Inoue; Menno P Witter; Toshio Iijima

  Frontiers in neuroscience, 2009, Peer-reviewed

  
• Dual transneuronal tracing in the rat entorhinal-hippocampal circuit by intracerebral injection of recombinant rabies virus vectors.

  Shinya Ohara; Ken-Ichi Inoue; Masahiro Yamada; Takuma Yamawaki; Noriko Koganezawa; Ken-Ichiro Tsutsui; Menno P Witter; Toshio Iijima

  Frontiers in neuroanatomy, 2009, Peer-reviewed

  
• Efficient gene transfer via retrograde transport in rodent and primate brains using a human immunodeficiency virus type 1-based vector pseudotyped with rabies virus glycoprotein.

  Shigeki Kato; Ken-ichi Inoue; Kenta Kobayashi; Yasunobu Yasoshima; Shigehiro Miyachi; Satoshi Inoue; Hideki Hanawa; Takashi Shimada; Masahiko Takada; Kazuto Kobayashi

  Human gene therapy, Nov. 2007, Peer-reviewed, Lead author

  
• A highly attenuated rabies virus HEP-Flury strain reverts to virulent by single amino acid substitution to arginine at position 333 in glycoprotein.

  Mutsuyo Takayama-Ito; Ken-Ichi Inoue; Yoko Shoji; Satoshi Inoue; Toshio Iijima; Takeo Sakai; Ichiro Kurane; Kinjiro Morimoto

  Virus research, Aug. 2006, Peer-reviewed

  
• A novel rapid fluorescent focus inhibition test for rabies virus using a recombinant rabies virus visualizing a green fluorescent protein.

  Pakamatz Khawplod; Ken-Ichi Inoue; Yoko Shoji; Henry Wilde; Sukathida Ubol; Akira Nishizono; Ichiro Kurane; Kinjiro Morimoto

  Journal of virological methods, Apr. 2005, Peer-reviewed

  
• An improved method for recovering rabies virus from cloned cDNA.

  Ken-ichi Inoue; Youko Shoji; Ichiro Kurane; Toshio Iijima; Takeo Sakai; Kinjiro Morimoto

  Journal of virological methods, Feb. 2003, Peer-reviewed, Lead author

  

Misc.

• Optogenetic Tagging of the Oculomotor Pathway in Non-Human Primates

  Yu X; Gopal PAA; Inoue K; Takada M; Hikosaka O

  Neuroscience 2023, Nov. 2023

  
• An AI system for quantification of common marmoset natural behaviors using markerless 3D pose estimation

  Zhao X; Kaneko T; Matsumoto J; Wanyi L; Ueno L; Oishi T; Ikenaka K; Baba K; Nishijo H; Mochizuki H; Inoue K; Takada M

  Neuroscience 2023, Nov. 2023

  
• Dopamine signals transmitted to different subregions of the primate striatum during economic decision-making

  Duo Z; Wang Y; Nejime M; Kunimatsu J; Amita H; Inoue K; Takada M; Yamada H; Matsumoto M

  Neuroscience 2023, Nov. 2023

  
• Characterizing the functional role of Interhemispheric Connections in value decisions using optical tools.

  Gopal PAA; You X; C. Mejias-Aponte C; Inoue K; Takada M; Hikosaka O

  Neuroscience 2023, Nov. 2023

  
• Parvalbumin-positive neuron-selective gene transduction into the monkey striatum

  Zheng A; Kimura K; Nagai Y; Fujiwara M; Nakano M; Nagayasu K; K Inoue K; Takada M

  Neuroscience 2023, Nov. 2023, Corresponding author

  
• Neural representations of medial prefrontal cortex neurons projecting to the striatum for diminishing reward-based action switch

  Nonmura S; Kaneko T; Amita H; Inoue K; Takada M

  Neuroscience 2023, Nov. 2023

  
• Behavioral adjustment in response to others’ internal state in common marmosets: AI based quantification using neural networks that predict the internal state solely from actions.

  Lu W; Kaneko T; Matsumoto J; Zhao X; Ueno L; Oishi T; Inoue K; Takada M

  Neuroscience 2023, Nov. 2023

  
• Selective silencing of the ventral striatum-ventral pallidum pathway enhances approach choices and motivational states under approach-avoidance conflict in nonhuman primates

  Oh J; Amemori S; Inoue K; Kimura K; Takada M; Amemori K

  Neuroscience 2023, Nov. 2023

  
• 化学遺伝学的手法を用いた神経活動抑制によるデフォルトモードネットワーク変容とその理解

  堀 祐樹; 永井 裕司; 小山 佳; 新田 展大; 柴田 さやか; 堀 由紀子; 岩沖 晴彦; 張 明栄; 井上 謙一; 高田 昌彦; 小畠 隆行; 樋口 真人; 平林 敏行; 南本 敬史

  第51回日本磁気共鳴医学会大会, Sep. 2023

  
• Diurnal rhythm of Learning and memory regulated by SCOP in mice and nonhuman primates

  Shimizu K; Inoue K; Oishi T; Takada M; Imai H; Fukada Y

  11th IBRO World Congress of Neuroscience, Sep. 2023

  
• マカクザルの前部帯状皮質から中脳中心灰白質への局在投射

  曽我 ゆふき; 吉野 倫太郎; 木村 慧; 大原 慎也; 中村 晋也; 井上 謙一; 髙田 昌彦; 筒井 健一郎

  第46回日本神経科学大会, Aug. 2023

  
• 動機づけ課題中の霊長類大脳皮質神経活動への自発的な体動の寄与

  瀬原 慧祐; 近藤 将史; 蝦名 鉄平; 平山 由香; 寺田 晋一郎; 正水 芳人; 高司 雅史; 渡我部 昭哉; 井上 謙一; 山森 哲雄; 松崎 政紀

  第46回日本神経科学大会, Aug. 2023

  
• 報酬の漸減に基づいた行動選択に関わる内側前頭前皮質からの情報伝達

  野々村 聡; 兼子 峰明; 網田 英敏; 井上 謙一; 高田 昌彦

  第46回日本神経科学大会, Aug. 2023

  
• 概日時計によって制御される哺乳類の記憶・学習

  清水 貴美子; 井上 謙一; 小林 洋大; 大石 高生; 高田 昌彦; 今井 啓雄; 深田 吉孝

  第46回日本神経科学大会, Aug. 2023

  
• Behavioral adjustment to others’ internal states in the common marmosets under a food competition task

  Wanyi Lu; Takaaki Kaneko; Jumpei Matsumoto; Xincheng Zhao; Louie Ueno; Takao Oishi; Ken-ichi Inoue; Masahiko Takada

  第46回日本神経科学大会, Aug. 2023

  
• A versatile tool for automated quantification of natural/social behaviors in the common marmosets

  Xincheng Zhao; Takaaki Kaneko; Jumpei Matsumoto; Wanyi Lu; Louie Ueno; Takao Oishi; Kensuke Ikenaka; Kousuke Baba; Hisao Nishijo; Hideki Mochizuki; Ken-ichi Inoue; Masahiko Takada

  第46回日本神経科学大会, Aug. 2023

  
• マウス CD25特異的組換え体イムノトキシンを利用したコモンマーモセット脳内神経細胞種の選択的ターゲティング

  小林 とも子; 加藤 成樹; 菅原 正晃; 小澤 龍彦; 井上 謙一; 高田 昌彦; 恩田 正徳; 小林 和人

  第46回日本神経科学大会, Aug. 2023

  
• Medial prefrontal cortex neuron negatively controls action switch based on diminishing reward in rats

  Nonomura S; Takayasu T; Kaneko T; Amita H; Inoue K; Takada M

  XIVth Meeting for International Basal Ganglia Society, Jun. 2023

  
• A fluorescent dopamine sensor reveals distinct signals on reward prediction error and expected reward value in the primate putamen and caudate nucleus

  Yan G; Amita H; Nonomura S; Inoue K; Takada M

  XIVth Meeting for International Basal Ganglia Society, Jun. 2023

  
• A versatile tool for automated quantification of natural behavior in marmosets

  Kaneko T; Matsumoto J; Lu W; Zhao X; Ueno L; Nishijo H; Mochizuki H; Inoue K; Takada M

  生理研研究会「行動制御の脳内基盤理解へのマルチディシプリナリーアプローチ」、国際研究集会「大脳皮質ー大脳基底核神経回路の機能とその破綻がもたらす機能障害」, Mar. 2023

  
• Distinct patterns of dopamine and striatal responses to reward association in primate caudate nucleus and putamen

  Amita H; Yan G; Nonomura S; Ioue K; Takada M

  生理研研究会「行動制御の脳内基盤理解へのマルチディシプリナリーアプローチ」、国際研究集会「大脳皮質ー大脳基底核神経回路の機能とその破綻がもたらす機能障害」, Mar. 2023

  
• Optogenetic stimulation of dopamine signals transmitted to the ventral striatum during ongoing decision-making process affects economic choice behavior in macaque monkeys

  Nejime M; Yun M; Kawai T; Kunimatsu J; Yamada H; Inoue K; Takada M; Matsumoto M

  Neuroscience 2022, Nov. 2022

  
• Non-invasive T1w/T2w myelin mapping of nonhuman primates: interspecies comparison of cortical structure of macaque, night monkey, and marmoset

  Ikeda T; Autio J; Kawasaki A; Takeda C; Ose T; Takada M; Essen V D; Glasser M F; Hayashi T

  Neuroscience 2022, Nov. 2022

  
• Distinct patterns of dopamine responses to reward association in primate caudate nucleus and putamen as revealed by dLight signals

  Yan G; Amita H; Nonomura S; Inoue K; Takada M

  Neuroscience 2022, Nov. 2022

  
• Medial prefrontal cortex neuron activity in relation to diminishing reward-based action selection in rats

  Nonomura S; Takayasu T; Kaneko T; Amita H; Inoue K; Takada M

  Neuroscience 2022, Nov. 2022

  
• Dynamic and pathway-specific signaling in the dorsomedial striatum and dopamine neurons during behavioral adaptation

  Rios A; Nonomura S; Sakai Y; Kato S; Kobayashi K; Takada M; Isomura Y; Kimura M

  第45回日本神経科学大会, Jul. 2022

  
• Fluorescent sensor reveals dopamine dynamics in the primate striatum

  Yan G; Amita H; Nonomura S; Inoue K; Takada M

  第45回日本神経科学大会, Jul. 2022

  
• 報酬を基にした柔軟な意思決定における、サル前頭眼窩野－尾状核および視床MD核経路の異なる役割

  小山 佳; 間島 慶; 永井 裕司; 堀 由紀子; 平林 敏行; Mark A G Eldridge; 宮川 尚久; 三村 喬生; 藤本 敦; 井上 謙一; Richard C Saunders; 高田 昌彦; 八幡 憲明; 八幡 憲明; 樋口 真人; Barry J Richmond; 南本 敬史

  第45回日本神経科学大会, Jul. 2022

  
• 群飼ケージ内で自由行動する複数サル個体の3Dマーカーレスモーションキャプチャー

  松本 惇平; 兼子 峰明; 木村 慧; Negrete Salvador; 橋本-須田 直子; 兼子 明久; 森本 真弓; 角谷 絵里; 西丸 広史; 瀬戸川 剛; 郷 康広; 柴田 智広; 西条 寿夫; 高田 昌彦; 井上 謙一

  第45回日本神経科学大会, Jul. 2022, Last author, Corresponding author

  
• 霊長類脳への高効率な導入遺伝子発現と神経細胞特異的な感染を実現するモザイクAAVベクターの開発

  木村 慧; 永井 裕司; 畑中 岳; Yang Fang; 田辺 創思; Andi Zheng; 藤原 真紀; 中野 真由子; 堀 由紀子; 竹内 遼介; 稲垣 未来男; 南本 敬史; 藤田 一郎; 井上 謙一; 高田 昌彦

  第45回日本神経科学大会, Jul. 2022

  
• サル脳内DREADD発現と効果の長期的評価

  永井 裕司; 堀 由紀子; 井上 謙一; 小山 佳; 宮川 尚久; 平林 敏行; 三村 喬生; 須原 哲也; 高田 昌彦; 樋口 真人; 南本 敬史

  第45回日本神経科学大会, Jul. 2022

  
• ウィルストレーシングによるマカクザル内側前頭皮質から扁桃体への投射様式

  吉野 倫太郎; 木村 慧; 田辺 創思; アンディ チェン; 中村 晋也; 大原 慎也; 井上 謙一; 高田 昌彦; 筒井 健一郎

  第45回日本神経科学大会, Jul. 2022

  
• 黒質-線条体路ドーパミン伝達による行動関連ニューロン活動の報酬履歴への依存性

  野々村 聡; リオス アライン; 加藤 成樹; 酒井 裕; 南部 篤; 高田 昌彦; 小林 和人; 木村 實; 礒村 宜和

  第45回日本神経科学大会, Jul. 2022

  
• ドーパミン受容体D1とD2の発現が偏る尾側線条体の腹側領域は、黒質外側部に投射する

  苅部 冬紀; 緒方 久実子; 角野 風子; 平井 康治; 高田 昌彦; 井上 謙一; 藤山 文乃

  第45回日本神経科学大会, Jul. 2022

  
• 霊長類腹側線条体–腹側淡蒼球の経路選択的抑制は接近回避葛藤タスク時の意欲を向上させる

  OH Jungmin; 雨森 智子; 井上 謙一; 木村 慧; 高田 昌彦; 雨森 賢一

  第45回日本神経科学大会, Jul. 2022

  
• サル大脳皮質におけるグリア細胞の時期および領野特異的な動態変化

  山中 智子; 田中 江美子; 高田 昌彦; 井上 謙一

  第45回日本神経科学大会, Jul. 2022, Last author, Corresponding author

  
• マウス尾側線条体における直接路・間接路細胞の分布と投射様式

  緒方久美子; 苅部冬紀; 角野風子; 平井康治; 井上謙一; 高田昌彦; 藤山文乃

  第127回日本解剖学会総会・全国学術集会, Mar. 2022

  
• 細胞種特異的分子マーカーと投射関係を用いたマカクザル嗅内皮質V層の構造解析

  吉野倫太郎; 木村慧; 田辺創思; Andi Zheng; 中村晋也; 大原慎也; 井上謙一; 高田昌彦; 筒井健一郎

  第99回日本生理学会大会, Mar. 2022

  
• アデノ随伴ウイルスベクターを用いたマーモセット全脳への効率の良い遺伝子導入法の開発

  吉田哲; 井上謙一; 兼子峰明; 高田昌彦; 岡野栄之

  第11回日本マーモセット研究会, Feb. 2022

  
• Chemogenetic suppression of pharmacologically induced frontal lobe epilepsy in a macaque monkey

  Miyakawa N; Nagai Y; Kawasaki K; Hori Y; Oyama K; Orihara A; Matsuo T; Suzuki T; Inoue K; Takada M; Suhara T; Higuchi M; Minamimoto T

  75th Annual Meeting of the American Epilepsy Society, Dec. 2021

  
• Causal role of midbrain dopamine neurons and ventral striatum circuit in economic decision-making in macaque monkeys

  Nejime M; Yun M; Kawai T; Yamada H; Inoue K; Takada M; Matsumoto M

  Neuroscience 2021, Nov. 2021

  
• Chronic behavioral manipulation via orally delivered chemogenetic actuator in macaque monkeys

  Oyama K; Hori Y; Nagai Y; Miyakawa N; Mimura K; Hirabayashi T; Inoue K; Takada M; Higuchi M; Minamimoto T

  Neuroscience 2021, Nov. 2021

  
• Pathway-selective silencing of ventral striatum neurons projecting to the ventral pallidum elevates motivational states under approach-avoidance conflict in nonhuman primates

  Oh J; Amemori S; Inoue K; Kimura K; Takada M; Amemori K

  Neuroscience 2021, Nov. 2021

  
• Use of an infrared-monitored staircase device in analyzing symptom progression of preformed fibril- and virus vector-induced alpha-synuclein overexpression in the common marmoset.

  Ueno-Nigh LR; Kaneko T; Oishi T; Inoue K; Takada M

  Neuroscience 2021, Nov. 2021

  
• 内側前頭極は記憶と社会的な視覚・聴覚情報を統合する

  石田裕昭; 井上謙一; 木村 慧; 高田昌彦

  日本心理学会, Aug. 2021

  
• 化学遺伝学によるてんかん制御～薬剤モデルマカクザル研究

  宮川 尚久; 永井 裕司; 川嵜 圭祐; 堀 由紀子; 小山 佳; 折原 あすみ; 松尾 健; 鈴木 隆文; 井上 謙一; 高田 昌彦; 須原 哲也; 樋口 真人; 南本 敬史

  第44回日本神経科学大会, Jul. 2021

  
• 課題遂行中のサル第一次視覚野からの微小内視鏡カルシウムイメージング

  小口 峰樹; Jiang Jiasen; 吉岡 敏秀; 田中 康裕; 井上 謙一; 髙田 昌彦; 菊水 健史; 野元 謙作; 坂上 雅道

  第44回日本神経科学大会, Jul. 2021

  
• 精神神経疾患の霊長類モデル確立に向けたマカクザルのマーカーレスモーションキャプチャー用大規模教師データセットの作成とその応用

  松本 惇平; ラブグエン ローリン; 兼子 峰明; ブランコ サルバトール; ジア グオ; 西丸 広史; 西条 寿夫; 高田 昌彦; 郷 康広; 井上 謙一; 柴田 智広

  第44回日本神経科学大会, Jul. 2021

  
• 細胞種特異的分子マーカーと神経トレーサーを用いたマカクザル嗅内皮質の構造解析

  吉野 倫太郎; 川村 太一; 中村 晋也; 木村 慧; 田辺 創思; Andi Zheng; 井上 謙一; 高田 昌彦; Menno Witter; 筒井 健一郎; 大原 慎也

  第44回日本神経科学大会, Jul. 2021

  
• 化学遺伝学的手法を用いた霊長類側坐核の活動低下は接近回避葛藤タスク開始時の意欲を低下させる

  オ ジョンミン; 雨森 智子; 井上 謙一; 木村 慧; 高田 昌彦; 雨森 賢一

  第44回日本神経科学大会, Jul. 2021

  
• 霊長類線条体へのパルブアルブミン陽性ニューロン選択的遺伝子導入

  Andi Zheng; 木村 慧; 永井 佑茉; 藤原 真紀; 中野 真由子; 永安 一樹; 井上 謙一; 高田 昌彦

  第44回日本神経科学大会, Jul. 2021, Corresponding author

  
• 背外側線条体・間接路細胞による予測的行動選択信号

  野々村 聡; Alain Rios; 加藤 成樹; 酒井 裕; 南部 篤; 高田 昌彦; 小林 和人; 礒村 宜和; 木村 實

  第44回日本神経科学大会, Jul. 2021

  
• 改変AAVベクターを用いた非ヒト霊長類新生仔への全脳的遺伝子導入

  井上 謙一; 木村 慧; 吉田 哲; 田辺 創思; 藤原 真紀; 上野 瑠惟; 高田 裕生; 兼子 峰明; 篠本 有里; 中野 真由子; 田中 江美子; 角谷 絵里; 岡野 栄之; 高田 昌彦

  第44回日本神経科学大会, Jul. 2021, Lead author

  
• 経済学的意思決定に関わるサル報酬系神経活動ダイナミクス

  禰占 雅史; 惲 夢曦; 川合 隆嗣; 山田 洋; 井上 謙一; 高田 昌彦; 松本 正幸

  第44回日本神経科学大会, Jul. 2021

  
• タンパク質を構成要素とする膜電位感受性プローブと神経選択性ウイルスベクターを用いた神経細胞の光学的膜電位測定(Optical monitoring of membrane potential changes of neurons using protein-based voltage-sensitive probe and neuron specific vectors)

  井上 謙一; 一條 宏; 大原 慎也; 筧 慎治; 市川 道教; 飯島 敏夫

  神経化学, Aug. 2004

  
• Primate models for elucidation of higher brain functions and treatment of psychiatric and neurological diseases

  高田 昌彦; 井上 謙一

  生体の科学, Jan. 2010

  
• Age-dependent distribution change of amyloid-beta protein in macaque brains

  K. Kimura; K. Inoue; F. Tanaka; M. Takada

  MOVEMENT DISORDERS, Jun. 2015

  
• 化学遺伝学とPETイメージングによるサル脳活動操作とモニタリング

  永井裕司; 宮川尚久; HAUNG Xi-Ping; SLOCUM Samuel T.; XIONG Yan; 堀由紀子; 小山佳; 季斌; 平林敏行; 藤本淳; 三村喬生; ENGLISH Justin G.; LIU Jing; 井上謙一; 熊田勝志; 関千江; 張明栄; 須原哲也; 高田昌彦; 樋口真人; JIN Jian; ROTH Bryan L.; 南本敬史

  日本獣医麻酔外科学雑誌(Web), 2019

  
• MacaquePose: A Novel "In the Wild" Macaque Monkey Pose Dataset for Markerless Motion Capture.

  Labuguen R; Matsumoto J; Negrete SB; Nishimaru H; Nishijo H; Takada M; Go Y; Inoue K; Shibata T

  Computer Vision and Pattern Recognition (CVPR) 2021, CV4Animals: Computer Vision for Animal Behavior Tracking and Modeling, Jun. 2021

  
• Multiple Monkey Pose Estimation Using OpenPose

  Negrete SB; Labuguen R; Matsumoto J; Go Y; Inoue K; Shibata T

  25th INternational Conference on Pattern recognition (IPCR 2021), Jan. 2021, Peer-reviewed

  
• 街上毒狂犬病ウイルスの脳内侵入経路に関する実験病理学的研究

  河合 せりな; 志和 希; 君付 和範; 山田 健太郎; 井上 謙一; 井上 智; 朴 天鎬

  第163回日本獣医学会学術集会, Sep. 2020, Peer-reviewed

  
• 扁桃体が腹側視覚皮質における社会・情動性の視覚情報表現に果たす役割 ～化学遺伝学神経操作によるアプローチ

  宮川 尚久; 永井 裕司; 堀 由紀子; 松尾 健; 鈴木 隆文; 井上 謙一; 小山 桂; 平林 敏行; 高田 昌彦; 須原 哲也; 樋口 真人; 川嵜 佳祐; 南本 敬史

  第43回日本神経科学大会, Jul. 2020, Peer-reviewed

  
• マカクザル内側前頭皮質の側坐核及び扁桃体への投射様式の違いによる領域区分

  吉野 倫太郎; 木村 慧; 田辺 創思; 大原 慎也; 中村 晋也; 井上 謙一; 高田 昌彦; 筒井健一郎

  第43回日本神経科学大会, Jul. 2020, Peer-reviewed

  
• DREADDを用いた経路選択的阻害法による、サル前頭前野と視床MD核及び線条体を結ぶ神経経路のワーキングメモリにおける役割の解明

  小山 佳; 堀 由紀子; 永井 裕司; 宮川 尚久; 三村 喬生; 平林 敏行; 井上 謙一; 高田 昌彦; 樋口 真人; 南本 敬史

  第43回日本神経科学大会, Jul. 2020, Peer-reviewed

  
• マカク一次視覚野における微小内視鏡を用いたカルシウムイメージング

  小口-田中 峰樹; 蔣 嘉森; 吉岡 敏秀; 田中 康裕; 井上 謙一; 高田 昌彦; 菊水 健史; 野元 謙作; 坂上 雅道

  第43回日本神経科学大会, Jul. 2020, Peer-reviewed

  
• 改変AAVベクターを用いた新生児霊長類への全脳的遺伝子導入

  井上 謙一; 田辺 創思; 吉田 哲; 藤原 真紀; 木村 慧; 上野 瑠惟; 高田 裕生; 木村 活生; 兼子 峰明; 篠本 有里; 中野 真由子; 田中 江美子; 今度 ゆりこ; 角谷 絵里; 岡野 栄之; 高田 昌彦

  第43回日本神経科学大会, Jul. 2020, Peer-reviewed, Lead author

  
• マカカ属サルにおける上丘から扁桃体への多シナプス性経路

  稲垣 未来男; 井上 謙一; 田辺 創思; 木村 慧; 高田 昌彦; 藤田 一郎

  第43回日本神経科学大会, Jul. 2020, Peer-reviewed

  
• 価値にもとづく眼球運動を制御する霊長類大脳基底核回路

  網田 英敏; Hyoung F Kim; 井上 謙一; 高田 昌彦; 彦坂 興秀

  第43回日本神経科学大会, Jul. 2020, Peer-reviewed

  
• The modified adeno associated virus vectors enable neuron specific efficient gene transduction in the primate brain

  Kimura K; Nagai Y; Tanabe S; Zheng A; Fujiwara M; Nakano M; Minamimoto T; Inoue K; Takada M

  Neuroscience 2019, Oct. 2019, Peer-reviewed

  
• Retrograde gene transfer efficiency and inflammatory response of two types of lentiviral vectors in the motor cortex input system of nonhuman primates and rodents

  Otsuka Y; Tsuge H; Uesono S; Tanabe S; Fujiwara M; Miwa M; Kato S; Nakamura K; Kobayashi K; Inoue K; Takada M

  Neuroscience 2019, Oct. 2019, Peer-reviewed

  
• Pathway-selective optogenetic modulation of amygdala-basal ganglia circuits in macaque monkeys

  Maeda K; Inoue K; Takada M; Hikosaka O

  Neuroscience 2019, Oct. 2019, Peer-reviewed

  
• Fast subcortical processing of emotional faces: evidence from physiology and anatomy in macaque monkeys

  Inagaki M; Inoue K; Takada M; Fujita I

  42nd edition of the European Conference on Visual Perception (ECVP 2019), Aug. 2019, Peer-reviewed

  
• DREADD inactivation of orbitofrontal cortex revealed its critical role in reward-based adaptive decision making in monkeys

  Oyama K; Hori Y; Nagai Y; Hirabayashi T; Miyakawa N; Fujimoto A; Mimura K; Inoue K; Eldridge A M; Saunders C R; Suhara T; Takada M; Higuchi M; Richmond J B; Minamimoto T

  第42回日本神経科学大会, Jul. 2019, Peer-reviewed

  
• Chemogenetic activation of the amygdala specifically disrupts the representation of socio-emotional information in the macaque ventral visual cortex

  Miyakawa N; Nagai Y; Hori Y; Matsuo T; Suzuki T; Inoue K; Takada M; Suhara T; Kawasaki K; Minamimoto T

  第42回日本神経科学大会, Jul. 2019, Peer-reviewed

  
• DRG cells in Common marmoset: their contrasting property in the cell size and cell type specificity of gene delivery by AAVs

  Kudo M; Wupuer S; Inoue K; Takada M; Seki K

  第42回日本神経科学大会, Jul. 2019, Peer-reviewed

  
• Combined application of multiscale calcium imaging with GCaMP6s and intrinsic signal optical imaging in macaque visual cortex

  Hatanaka G; Fang Y; Inagaki M; Takeuchi R; Inoue K; Takada M; Fujita I

  第42回日本神経科学大会, Jul. 2019, Peer-reviewed

  
• Combined use of intrinsic optical imaging and 2-photon Ca2+ imaging for determining distribution of stimulus-specific responses across macro-architecture in macaque visual cortex

  Fang Y; Hatanaka G; Inagaki M; Takeuchi RF; Inoue K; Takada M; Fujita I

  15th Asia-Pacific Conference on Vision, Jul. 2019, Peer-reviewed

  
• A novel ligand “deschloroclozapine” selectively visualizes and activates chemogenetic receptors in non-human primates

  Nagai Y; Miyakawa N; Takuwa H; Hori H; Oyama K; Ji B; Takahashi M; Haung XP; Slocum ST; Xiong Y; Hirabayashi T; Fujimoto A; Mimura K; English JG; Liu J; Inoue K; Kumata K; Seki C; Ono M; Shimojo M; Zhang MR; Tomita Y; Suhara T; Takada M; Higuchi M; Jin J; Roth BL; Minamimoto T

  Brain and BrainPET 2019, Jul. 2019, Peer-reviewed

  
• Primate Markerless Pose Estimation and Movement Analysis Using DeepLabCut

  Labuguen R; Bardeloza DK; Blanco SN; Matsumoto J; Inoue K; Shibata T

  Joint 2019 8th International Conference on Informatics, Electronics & Vision (ICIEV) & 3rd International Conference on Imaging, Vision & Pattern Recognition (IVPR), May 2019, Peer-reviewed

  
• Macaque ventral midbrain facilitates the output to forelimb muscles via the primary motor cortex

  Suzuki M; Inoue K; Nakagawa H; Isa T; Takada M; Nishimura Y

  29th Annual Meeting of Neural Control of Mevement, Apr. 2019, Peer-reviewed

  
• 霊長類脳への神経細胞特異的かつ高効率な遺伝子導入を実現する改変AAVベクターの開発.

  木村 慧; 永井 裕司; 田辺 創思; Zheng Andi; Oh Jungmin; 藤原 真紀; 中野 真由子; 南本 敬史; 井上 謙一; 高田 昌彦

  第8回 生理研-霊長研-新潟脳研 合同シンポジウム, Mar. 2019

  
• Retrograde gene transfer efficacy and inflammatory response of lentiviral vectors pseudotyped with FuG-E vs. FuG-B2 glycoproteins in the striatal input system of primates and rodents.

  Tanabe S; Uezono S; Tsuge H; Fujiwara M; Nagaya K; Nagaya N; Sugawara M; Miwa M; Konoike N; Kato S; Nakamura K; Kobayashi K; Inoue K; Takada M

  第8回日本マーモセット研究会大会, Feb. 2019

  
• Deep brain stimulation of the ventral midbrain facilitates the output to forelimb muscles via the primary motor cortex in monkeys.

  Suzuki M; Inoue K; Nakagawa H; Isa T; Takada M; Nishimura Y

  3rd International Brain Stimulation Conference, Feb. 2019, Peer-reviewed

  
• Retrograde gene transfer efficacy and inflammatory response of HiRet vs. NeuRet lentiviral vectors in the motor cortical input system of nonhuman primates and rodents.

  Otsuka Y; Tsuge H; Uezono S; Tanabe S; Fujiwara M; Miwa M; Kato S; Nakamura K; Kobayashi K; Inoue K; Takada M

  第8回日本マーモセット研究会大会, Feb. 2019

  
• 融合糖タンパク質E型変異体を用いた神経特異的逆行性ウイルスベクターによるマーモセット脳内への遺伝子導入効率の向上.

  菅原正晃; 加藤成樹; 木村 慧; 井上 謙一; 高田 昌彦; 小林 和人

  第8回日本マーモセット研究会大会, Feb. 2019

  
• サル腹側中脳は一次運動野を介して筋出力を促通する.

  鈴木迪諒; 井上謙一; 中川浩; 伊佐正; 高田昌彦; 西村幸男

  次世代脳プロジェクト冬のシンポジウム, Dec. 2018

  
• Optogenetic activation of cutaneous and proprioceptive afferent in the rat sciatic nerve.

  Kubota S; Sidikejiang W; Kudoh M; Inoue K; Umeda T; Takada M; Seki K

  Neuroscience 2018, Nov. 2018, Peer-reviewed

  
• Monkey Features Location Identfication Using Convolutional Neural Networks

  Labuguen R; Gaurav V; Blanco SN; Matsumoto J; Inoue K; Shibata T

  第28回日本神経回路学会・全国大会, Oct. 2018, Peer-reviewed

  
• 高精細全脳イメージング技術FASTの開発と精神疾患モデルマウスの病態解析 ―脳全体を対象とした仮説フリーな病態・薬物治療機序の組織学的解析―

  勢力薫; 笠井淳司; 丹生光咲; 田沼将人; 五十嵐久人; 中澤敬信; 山口瞬; 井上謙一; 高田昌彦; 橋本均

  第68回日本薬学会近畿支部総会・大会, Oct. 2018, Peer-reviewed

  
• マーモセットの帯状皮質を巡る基底核連関構築様式

  上園志織; 田辺創思; 藤原真紀; 柘植仁美; 中村克樹; 井上謙一; 高田昌彦

  第33回 日本大脳基底核研究会, Aug. 2018

  
• Differences in retrograde gene transfer efficiency and cytotoxicity between lentiviral vectors pseudotyped with FuG-E, FuG-E2, and FuG-B2 glycoprotein in primate brains.

  Otsuka Y; Tanabe S; Tsuge H; Uezono S; Fujiwara M; Miwa M; Kato S; Nakamura K; Kobayashi K; Inoue K; Takada M

  International Workshop "Monitoring and manipulating brain function in non-human primates", Jul. 2018

  
• Neuron-specific efficient gene transduction in the primate brain with Morphological modified AAV vectors.

  Kimura K; Tanabe S; Fujiwara M; Nagai Y; Minamimoto T; Inoue K; Takada M

  International Workshop "Monitoring and manipulating brain function in non-human primates", Jul. 2018

  
• High-resolution imaging of primate brains using FAST.

  Hashimoto H; Seiriki K; Kasai A; Nakazawa T; Inoue K; Takada M

  International Workshop "Monitoring and manipulating brain function in non-human primates", Jul. 2018

  
• Microarchitecture of binocular disparity processing in V2: combined use of intrinsic optical imaging and 2-photon Ca2+ imaging.

  Fang Y; Hatanaka G; Inagaki M; Inoue K; Takada M; Fujita I

  International Workshop "Monitoring and manipulating brain function in non-human primates", Jul. 2018

  
• Pathway-selective optogenetic modulation of value-biased saccade circuits in the monkey basal ganglia.

  Amita H; Hikosaka O; Hyoung F.K; Inoue K; Takada M

  第41回日本神経科学大会, Jul. 2018, Peer-reviewed

  
• Enhanced gene transfer efficiency of neuron-specific retrograde lentiviral vector with variants of fusion glycoprotein type E into the mouse and common marmoset brains.

  Sugawara M; Kato S; Kimuta K; Inoue K; Takada M; Kobayashi K

  第41回日本神経科学大会, Jul. 2018, Peer-reviewed

  
• PET imaging of selective control of neural activity with a novel DREADD agonist.

  Nagai Y; Miyakawa N; Huang X; Slocum S; Ono M; Inoue K; Yan X; Liu J; English J; Shimojo M; Mimura K; Hirabayashi T; Bin J; Kumata K; Higuchi M; Zhang M; Takada M; Jin J; Roth B; Minamimoto T

  第41回日本神経科学大会, Jul. 2018, Peer-reviewed

  
• Using PET imaging to monitor chemogenetic manipulation of nigrostriatal dopamine system in common marmoset

  Mimura K; Nagai Y; Inoue K; Suhara T; Takada M; Minamimoto T

  International Workshop "Monitoring and manipulating brain function in non-human primates", Jul. 2018, Peer-reviewed

  
• Lentiviral vectors pseudotyped with FuG-E and FuG-E2 glycoprotein suitable for retrograde gene transfer into neural networks involving cerebral cortical areas in nonhuman primates and rodents.

  Otsuka Y; Tsuge H; Uezono S; Tanabe S; Fujiwara M; Miwa M; Kato S; Nakamura K; Kobayashi K; Inoue K; Takada M

  第41回日本神経科学大会, Jul. 2018, Peer-reviewed

  
• Neuron-specific efficient gene transduction in the primate brain with modified AAV vectors.

  Kimura K; Tanabe S; Fujiwara M; Nakano M; Nagai Y; Minamimoto T; Inoue K; Takada M

  第41回日本神経科学大会, Jul. 2018, Peer-reviewed

  
• パーキンソン病モデル動物におけるパーキン遺伝子治療の効果(平成19年度老人性疾患病態・治療研究センター研究発表会)

  安田 徹; 井上 謙一; 山崎 吉之; 仁平 友子; 早川 英規; 服部 信孝; 高田 昌彦; 島田 隆; 望月 秀樹; 水野 美邦

  順天堂医学, Sep. 2008

  
• ADVANCES IN PARKIN GENE THERAPY - A FOLLOW UP PRIMATE STUDY

  Hideki Mochizuki; Toru Yasuda; Tomoko Nihira; Kenichi Inoue; Yoshiyuki Yamazaki; Keiji Terao; Masahiko Takada; Takashi Shimada; Yoshikuni Mizuno

  JOURNAL OF GENE MEDICINE, Dec. 2009

  
• Advances in parkin gene therapy-a primate study

  Hideki Mochizuki; Toru Yasuda; Tomoko Nihira; Kenichi Inoue; Yoshiyuki Yamazaki; Keiji Terao; Masahiko Takada; Takashi Shimada; Yoshikuni Mizunol

  JOURNAL OF GENE MEDICINE, Apr. 2008

  
• Functional Neuroanatomy of Neurocircuit with an Optical Recording Method

  HIROSE Hideaki; INOUE Kenichi; ICHIJO Hiroshi; KOGANEZAWA Noriko; OBA Kenji; OHARA Shinya; KAKEHI Shinji; IIJIMA Toshio

  The Journal of the Institute of Electronics, Information and Communication Engineers, 01 Apr. 2004

  

Presentations

• ウイルスベクター入門

  井上 謙一

  第5回サル脳新技術研究会, 01 Mar. 2024, Invited

  
• 越シナプストレーシングによる霊長類大脳皮質―大脳基底核ループ回路の構造解析

  井上 謙一

  生理研研究会「多次元脳形態研究会」, 14 Dec. 2023, Invited

  
• Towards social behavior analysis in normal and disease model primates

  Ken-ichi Inoue

  「行動変容生物学」第1回国際シンポジウム, 25 Mar. 2023, Invited

  
• 越シナプストレーシングを利用した大脳皮質―大脳基底核ループ回路の構造解析

  井上 謙一

  生理研研究会「大脳皮質を中心とした神経回路：構造と機能、その作動原理」, 01 Dec. 2022, Invited

  
• A mosaic adeno-associated virus vector as a versatile tool for primate neuroscience

  Ken-ichi Inoue

  Viral Manipulation in Monkey, 19 Oct. 2022, Invited

  
• 光遺伝学による霊長類脳回路操作

  井上 謙一

  第126回日本眼科学会総会, 15 Apr. 2022, Invited

  
• 霊長類における光遺伝学を利用した神経回路操作

  井上 謙一

  日本動物学会第90回大阪大会, 28 Jul. 2019, Invited

  
• Pathway-selective activity manipulation in the primate brain by means of modified viral vectors

  Kenichi Inoue

  7th ESI Systems Neuroscience Conference 2020 (ESI SyNC 2020), 24 Aug. 2020, Invited

  
• Manipulation of primate neural networks by means of modified viral vectors

  Kenichi Inoue

  Molecular Genetic Tools for the Study of Neural Circuits, summer school, 13 Aug. 2019, Invited

  
• Neuronal and behavioural modulations by pathway-selective optogenetic stimulation of the primate oculomotor system

  Kenichi Inoue

  The Kyoto Symposium on the Eye and Head Movement Control Systems, 21 Apr. 2019, Invited

  
• Pathway-selective optogenetics for elucidating neural network function in primates

  Kenichi Inoue

  DFG-AMED joint Workshop "New Direction in Systems Neuroscience", 21 Mar. 2019, Invited

  
• ウイルスベクターを利用した霊長類における神経ネットワーク操作

  井上 謙一

  玉川大学総合人間科学ワークショップ, 14 Feb. 2019, Invited

  
• Pathway-selective manipulation of primate neural networks by means of modified viral vectors

  Kenichi Inoue

  ピッツバーグ大学セミナー, 17 Dec. 2018, Invited

  
• Pathway-selective manipulation of primate neural networks by means of modified viral vectors

  Kenichi Inoue

  Genetic technologies for systems neurosciences in non-human primates, 14 Dec. 2018, Invited

  
• Pathway-selective manipulation of neural network in primates

  Kenichi Inoue

  フライブルグ大学セミナー, 07 Dec. 2018, Invited

  
• Manipulation of primate neural networks by means of modified viral vectors

  Kenichi Inoue

  International Conference "Viral Manipuration in Monkey", 26 Sep. 2018

  
• Development of viral vectors for delivering functional molecules into nonhuman primate brains

  Kenichi Inoue

  International Workshop "Monitoring and manipulating brain function in non-human primates", 01 Aug. 2018, Invited

  
• Development of viral vectors for delivering functional molecules into nonhuman primate brains

  Kenichi Inoue

  The 41st Annual Meeting of the Japan Neuroscience Society, 29 Jul. 2018

  
• 霊長類における光遺伝学を利用した神経回路操作

  井上 謙一

  日本学術振興会 光電相互変換第125委員会 第239回研究会 「光技術が切り開く新しいバイオサイエンス・テクノロジー」, 15 Dec. 2017, Invited

  
• Pathway-selective optogenetics for elucidating neural network function in primates.

  Kenichi Inoue

  Neuroscience 2017, 11 Nov. 2017, Invited

  
• Pathway-selective manipulation of neural circuits

  Kenichi Inoue

  NIMH Workshop "Neural Circuits: Gaps and Opportunities", 11 Sep. 2017, Invited

  
• ウイルスベクターを利用した霊長類における神経ネットワーク操作

  井上 謙一

  第6回 生理研-霊長研-脳研 合同シンポジウム, 10 Mar. 2017, Invited

  
• Studying the structure and function of primate brain by using viral vectors

  Kenichi Inoue

  The 7th International Neural Microcircuit Conference, 08 Dec. 2016, Invited

  
• Manipulation of primate neural networks by means of modified viral vectors

  Kenichi Inoue

  National Institute of Health, Chemogenetics Workshop, 01 Dec. 2016, Invited

  
• Primate models for elucidating the circuit pathology of nigrostriatal dopamine system

  Kenichi Inoue

  第39回日本神経科学大会ｻﾃﾗｲﾄｼﾝﾎﾟｼﾞｳﾑ：大脳基底核の機能と疾患：基礎と臨床, 19 Jul. 2016, Invited

  
• Manipulation of primate neural networks by means of modified viral vectors.

  Ken-ichi Inoue

  5th NIPS-CIN Joint Symposium, 05 Nov. 2015, Invited

  
• Manipulation of primate neural networks by means of modified viral vectors.

  Inoue K; Takada M

  the 120th Annual Meeting of The Japanese Association of Anatomists, the 92nd Annual Meeting of The Physiological Society of Japan, 23 Mar. 2015, Invited

  
• 神経路選択的な遺伝子導入による神経ネットワークの機能操作

  井上 謙一

  生理研シンポジウム・グローバルネットワークによる脳情報処理, 01 Jan. 2014, Invited

  
• 霊長類脳研究に資する遺伝子導入技術の開発

  井上 謙一

  「霊長類認知ゲノミクス」キックオフワークショップ, 01 Oct. 2013, Invited

  
• Manipulation of primate neuronal circuits by the use of modified lentiviral vector with enhanced retrograde transport.

  Kenichi Inoue

  NIPS Mini-International Symposium "Frontiers in Neural Control of Actions", 17 Jun. 2013, Invited

  
• 神経路選択的な遺伝子導入による神経ネットワークの機能操作

  井上 謙一

  第９回ナショナルバイオリソースプログラム「ニホンザル」公開シンポジウム, 09 Nov. 2012, ナショナルバイオリソースプログラム「ニホンザル」, Invited

  
• ウィルスベクターを用いた霊長類神経系への高効率な遺伝子導入手法の開発とその応用

  井上 謙一

  第１３回予防衛生協会セミナー, Dec. 2009, 予防衛生協会, Invited

  

Books and Other Publications

• 月刊細胞 55(8): 特集「変貌する行動生物学」

  井上 謙一, Editor

  ニューサイエンス社, Jul. 2023

  
• 先端的行動解析がもたらす行動生物学の進化

  井上 謙一, Contributor, 2-3

  ニューサイエンス社、月刊細胞 55(8): 特集「変貌する行動生物学」, Jul. 2023

  
• 光遺伝学による霊長類脳の回路解析

  井上 謙一, Joint work, 8-16

  中外医学社、Annual Review 神経 2023（鈴木則宏、荒木信夫、宇川義一、桑原聡、塩川芳昭 編）, 中外医学社, Jun. 2023

  
• ウイルスベクター

  井上 謙一, Joint work, 202-203

  新興医学出版社、精神医学領域の論文を読みこなすキーワード100！（鬼塚俊明、橋本亮太 編）, Jan. 2023

  
• 5章 研究方法・研究戦略

  井上 謙一, Joint translation, 115-150

  丸善出版、カールソン神経科学テキスト ー脳と行動ー 原書13版（中村克樹 監訳）, Dec. 2022

  
• 光遺伝学による霊長類脳回路操作

  井上 謙一, Contributor, 301-310

  日本神経眼科学会、神経眼科 39(4): 別冊 特集「中枢機能をみる！～多様なアプローチによる中枢機能評価～」, Dec. 2022

  
• Nonhuman primate optogenetics: current status and future prospects.

  Ken-ichi Inoue, Joint work, 345-358

  Springer, Optogenetics (Advances in Experimental Medicine and Biology 1293) (ed. Hiromu Yawo, Hideki Kandori, Amane Koizumi, Ryoichiro Kageyama), Jan. 2021

  
• 大型霊長類脳神経系への遺伝子導入による活動操作・活動計測

  井上謙一; 高田昌彦, Contributor, 201-209

  羊土社、実験医学別冊, 「決定版 ウイルスベクターによる遺伝子導入実験ガイド」, Nov. 2020

  
• 霊長類眼球運動制御

  高田昌彦; 井上謙一; 松本正幸, Contributor, 914-915

  中外医学社、Clinical Neuroscience 36 「メインテーマ 光が開く神経科学の未来―オプトジェネティクスと光イメージング」, Aug. 2018, Not refereed

  
• 脳内の「やる気」スイッチを操作：霊長類の生体脳における人工受容体の画像化

  高田昌彦; 永井裕司; 井上謙一; 南本敬史, Contributor, 866-868

  医歯薬出版、医学のあゆみ,263:10, 「バソプレシンV2受容体拮抗薬のすべて」, Dec. 2017, Not refereed

  
• 光による霊長類脳機能制御：神経路選択的光操作技術

  高田昌彦; 井上謙一; 松本正幸, Contributor, 488-489

  医学書院、生体の科学,68:5,「特集 細胞多様性解明に資する光技術─見て，動かす」, Oct. 2017, Not refereed

  
• ウイルスベクターを用いた神経回路への機能介入法

  井上謙一; 高田昌彦, Contributor, 757-761

  中外医学社. Clinical Neuroscience 32:, 「脳のゆらぎ・同期・オシレーション」, Jul. 2014, Not refereed

  
• Vectors for highly efficient and neuron-specific retrograde gene transfer for gene therapy of neurological diseases.

  Kato S; Kobayashi K; Inoue K; Takada M; Kobayashi K, Contributor, 387-398

  Gene Therapy-Tools and Potential Applications. (ed. Francisco Martin Molina) InTech, Feb. 2013, Not refereed

  
• Organization of Two Cortico–Basal Ganglia Loop Circuits That Arise from Distinct Sectors of the Monkey Dorsal Premotor Cortex.

  Takada M; Hoshi E; Saga Y; Inoue K; Miyachi S; Hatanaka N; Inase M; Nambu A, Contributor, 103-116

  Basal Ganglia - An Integrative View. (ed. Fernando A. Barrios and Clemens Bauer) InTech, Jan. 2013, Not refereed

  
• Highly efficient retrograde gene transfer for genetic treatment of neurological diseases.

  Kato S; Kuramochi M; Kobayashi K; Inoue K; Takada M; Kobayashi K, Contributor, 371-380

  Viral Gene Ther. (ed.Ke Xu) InTech, Jul. 2011, Not refereed

  
• 狂犬病ウイルスによる多シナプス性神経路の解析法

  高田昌彦; 井上謙一; 宮地重弘, Contributor, 221-230

  医学書院、Brain and Nerve, 62:3,「特集 神経回路解析法の最近の進歩」, Mar. 2010, Not refereed

  
• 高次脳機能の解明と精神・神経疾患の克服のためのサルモデル

  高田昌彦; 井上謙一, Contributor, 53-58

  医学書院、生体の科学,61:1,「特集 脳科学のモデル実験動物」, Jan. 2010, Not refereed

  
• Prevention of calbindin recruitment into nigral dopamine neurons from MPTP-induced degeneration in Macaca fascicularis.

  Takada M; Inoue K; Miyachi S; Okado H; Nambu A, Contributor, 377-386

  Springer, The Basal Ganglia IX, Sep. 2009, Not refereed

  
• サル類モデル

  高田昌彦; 井上謙一, Contributor, 78-87

  アドスリー、老化・老年病研究のための動物実験ガイドブック 日本基礎老化学会編, Oct. 2008, Not refereed

  
• 光計測法による神経回路の機能的解剖

  広瀬秀顕; 井上謙一; 一條宏; 小金澤紀子; 大場健嗣; 大原慎也; 筧慎治; 飯島敏夫, Contributor, 265-271

  電子情報通信学会誌、87:4,「小特集 最大のフロンティア｢脳｣の解明に挑む―神経生理計測と神経科学―」, Apr. 2004, Not refereed

  

Industrial Property Rights

• 特願2021-088794, 非変性チャネルロドプシン検出キット

  加藤英明; 福田 昌弘; 濡木 理; 草木 迫司; 岩田 想; 野村 紀通; 劉 紅; 植村 智子; 井上 謙一

  
• 特開2006-81509, 神経回路選択的な外来遺伝子導入ベクターの製造方法

  井上謙一; 大原慎也; 森本金次郎; 倉根一郎; 筧慎治; 飯島敏夫

  

Awards

• Nov. 2008

  社団法人　予防衛生協会, 社団法人　予防衛生協会　研究奨励賞

External funds: Kakenhi

• 新規単シナプス性感染伝播ベクターを利用した神経回路選択的な活動計測・操作法の開発

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  井上 謙一

  From 01 Apr. 2020, To 31 Mar. 2022, Project Closed

  神経科学;脳・神経;バイオテクノロジー;ウイルスベクター;逆行性

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05062/
• Development of a non-invasive and area selective gene transfer method for the primate brain

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 46:Neuroscience and related fields

  Kyoto University

  Kenichi Inoue

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  神経科学;脳・神経;バイオテクノロジー;ウイルスベクター;霊長類

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22470/
• 霊長類の前頭前野を巡る「行動選択」神経ネットワークの構築様式

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  井上 謙一

  From 01 Apr. 2019, To 31 Mar. 2021, Project Closed

  神経科学;脳・神経;人工知能;ウイルスベクター;解剖学

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04984/
• Structure and function of primate cortico-basal ganglia loop circuits involved in procedural learning

  Grant-in-Aid for Scientific Research (B)

  Basic Section 46020:Anatomy and histopathology of nervous system-related

  Kyoto University

  Ken-ichi Inoue

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  神経科学;脳・神経;ウイルスベクター;解剖学;手続き学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03335/
• 行動選択の回路モデル構築のための前頭前野―大脳基底核・小脳連関の構築様式の解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  井上 謙一

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  神経科学;脳・神経;人工知能;ウイルスベクター;解剖学;バイオテクノロジー;オプトジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H06030/
• 神経回路の選択的可視化と操作を実現するウイルスベクターシステムの開発

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  井上 謙一

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  神経科学;脳・神経;バイオテクノロジー;ウイルスベクター;霊長類;オプトジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H05565/
• Rapid detection of threat signals in primate amygdala

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Ichiro Fujita

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  扁桃体;大脳皮質視覚野;表情認識;迅速経路仮説;狂犬病ウイルス;危険認知;新生児微笑;自閉症;視床枕;上丘;表情弁別;皮質下経路;霊長類;サポートベクターマシン;情動;顔表情;脅威信号;顔認識;大脳皮質側頭葉;ディープラーニング;側頭葉視覚連合野;単一細胞活動;神経科学;生理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H01381/
• Elucidation of the pathogenic mechanism of progression of Parkinson's disease using a primate genetic modification model

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kenichi Inoue

  From 19 Jul. 2016, To 31 Mar. 2019, Project Closed

  神経科学;脳神経疾患;パーキンソン;ウイルスベクター;霊長類;ウィルスベクター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16KT0193/
• Development of a novel technique for widespread gene transduction into neurons throughout the primate brain by the use of viral vectors.

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Inoue Kenichi

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  神経科学;脳・神経;バイオテクノロジー;ウイルスベクター;霊長類

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14316/
• Optogenetic approach to understand neural mechanisms underlying visual attention in monkeys

  Grant-in-Aid for Challenging Exploratory Research

  University of Tsukuba

  Masayuki MATSUMOTO

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  視覚的注意;ドーパミンニューロン;前頭前野;光遺伝学;サル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K12766/
• Understanding osicllatory phenomena by bidirectional interaction tools

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Tohoku University

  Hajime Mushiake

  From 29 Jun. 2015, To 31 Mar. 2020, Project Closed

  振動現象;大脳皮質;脳波;遺伝子導入;シータ波;光操作;脳振動現象;オッシレーション;遺伝子操作;神経科学;内因性振動;抑制細胞;脳・神経;脳活動の振動

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-15H05879/
• 神経回路の選択的可視化と操作を実現するウイルスベクターシステムの開発

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  井上 謙一

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  神経科学;脳・神経;バイオテクノロジー;ウイルスベクター;霊長類;オプトジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01431/
• Role of dopamine signals in prefrontal executive functions

  Grant-in-Aid for Young Scientists (A)

  University of Tsukuba

  Masayuki Matsumoto

  From 01 Apr. 2014, To 31 Mar. 2018, Project Closed

  ドーパミンニューロン;行動抑制;尾状核;前頭前野;ドーパミン;response inhibition;ドーパミン受容体拮抗薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26710001/
• Innovation of chemiluminogenetics capable of noninvasive manipulation of biological functions deep inside body

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Takeharu Nagai

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  発光タンパク質;光感受性タンパク質;オプトジェネティクス;発光基質;ケミルミノジェネティクス;化学発光タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26251018/
• Developmental transcriptome analysis of monkey brain for the establishment of human disease model

  Grant-in-Aid for Challenging Exploratory Research

  Center for Novel Science Initatives, National Institutes of Natural Sciences;Kyoto University

  Yasuhiro GO

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  バイオリソース;モデル動物;ゲノム;霊長類;脳;トランスクリプトーム;疾患;リサーチバイオリソース;エピジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24650234/
• Development of a novel technique for analyzing anatomical and functional difference in the nigral dopamine neurons by the use of viral vectors.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Ken-ichi INOUE

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  神経科学;脳・神経;バイオテクノロジー;ウイルスベクター;解剖学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24500379/
• 霊長類における神経路選択的な機能分子制御技術の開発

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  井上 謙一

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  神経科学;脳・神経;バイオテクノロジー;ウイルスベクター;認知科学

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23115708/
• Development of novel vector systems for neuronal tracing based on recombinant rabies virus vectors.

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Ken-ichi INOUE

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  神経科学;脳・神経;ウイルスベクター;解剖学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22650063/
• Analysis of cortico-basal ganglia loop circuits with novel retrograde transneuronal tracing technique

  Grant-in-Aid for Young Scientists (B)

  Tokyo Metropolitan Organization for Medical Research

  Ken-ichi INOUE

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  神経科学;脳-神経;脳情報処理;解剖学;大脳基底核;ウイルスベクター;脳・神経;解部学;バイオラクノロジー;ウィルス;バイオテクノロジー;ウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20700308/
• 行動変容を支える広域脳ネットワークの構造解明とその制御

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  井上 謙一

  From 16 Jun. 2022, To 31 Mar. 2027, Granted

  霊長類;ウイルスベクター;トレーシング;行動解析;社会行動

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22H05157/
• 先端モデル動物支援プラットフォーム

  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)

  The University of Tokyo

  武川 睦寛

  From 01 Apr. 2022, To 31 Mar. 2028, Granted

  モデル動物作製;ゲノム編集;病理形態解析;生理機能解析;分子プロファイリング;分子探索・プロファイリング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04922/
• 全脳的遺伝子導入による霊長類疾患モデル動物作成法の確立

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 51:Brain sciences and related fields

  Kyoto University

  井上 謙一

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  霊長類;ウイルスベクター;疾患モデル;行動解析;モーションキャプチャ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19480/
• Biology of Behavior Change: Brain Dynamics x Behavior Change

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  The University of Tokyo

  松崎 政紀

  From 16 Jun. 2022, To 31 Mar. 2027, Granted

  行動変容;多次元データ;細胞機能構築;情報処理;標準化

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-22H05154/
• サル扁桃体―背側縫線核回路の化学遺伝学的操作によるストレス下行動制御機構の解明

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 51:Brain sciences and related fields

  Kansai Medical University

  中村 加枝

  From 30 Jun. 2022, To 31 Mar. 2025, Granted

  背側縫線核;扁桃体;セロトニン;ストレス;化学遺伝学的操作;ウイルスベクター;背測縫線核

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19485/
• マルチモーダルスキルを支える大脳皮質－大脳基底核連関の情報処理様式

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51010:Basic brain sciences-related

  Kyoto University

  井上 謙一

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  スキル;霊長類;大脳基底核;ウイルスベクター;トレーシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02781/
• 蛍光イメージングを用いた霊長類の注意機能を支えるモノアミン神経回路機構の解明

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 51:Brain sciences and related fields

  Kyoto University;University of Tsukuba

  松本 正幸

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  ドーパミン;セロトニン;注意;非ヒト霊長類

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00412/
• マルチモーダルスキルを支える大脳皮質－大脳基底核連関の情報処理様式

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51010:Basic brain sciences-related

  Kyoto University

  井上 謙一

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  スキル;霊長類;大脳基底核;ウイルスベクター;トレーシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27472/
• Neuronal mechanism of skillful hand movement of non-human primates

  Grant-in-Aid for Scientific Research (S)

  Broad Section I

  National Center of Neurology and Psychiatry

  関 和彦

  From 12 Apr. 2023, To 31 Mar. 2028, Granted

  霊長類;把握運動;感覚シナジー;筋シナジー;脊髄

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H05488/

External funds: others

• 網膜色素変性に対する革新的なcDNA挿入型ゲノム編集遺伝子治療の開発

  国立研究開発法人日本医療研究開発機構, 難治性疾患実用化研究事業（再生・細胞医療・遺伝子治療のシーズ探索研究）

  From 01 Apr. 2023, To 31 Mar. 2026

  西口康二

  井上謙一
• 分子操作と姿勢計測の基盤技術開発

  目標 9「逆境の中でも前向きに生きられる社会の実現」（PM：山田真希子）

  国立研究開発法人科学技術振興機構, ムーンショット型研究開発事業

  From 08 May 2023, To 31 Mar. 2027

  研究開発担当者：井上謙一
• 光操作による神経ネットワークの高解像度5D解析法の確立を目指した基盤技術開発

  国立研究開発法人科学技術振興機構, 戦略的創造研究推進事業（さきがけ）

  From 01 Oct. 2016, To 31 Mar. 2020

  井上　謙一
• 霊長類におけるニューロン種選択的な遺伝子発現制御手法の開発

  国立研究開発法人日本医療研究開発機構, 戦略的国際脳科学研究推進プログラム・先進的個別研究開発課題

  From 20 Nov. 2018, To 31 Mar. 2021

  井上　謙一

  永安 一樹

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Special Lecture on Biological Science 13

  9917, Year-long, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Practical on Neuroscience

  9656, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Primate Systems Neuroscience

  9651, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Fundamental Primate Neuroscience I

  9641, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Special Lecture on Biological Sciences 2

  7741, Year-long, Faculty of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Systems Neuroscience D

  9685, Fall, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Systems Neuroscience C

  9684, Spring, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Systems Neuroscience B

  9683, Fall, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Primate Systems Neuroscience A

  9682, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Practical on Neuroscience

  9656, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Primate Systems Neuroscience

  9651, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Fundamental Primate Neuroscience I

  9641, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Systems Neuroscience C

  9684, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Systems Neuroscience B

  9683, Fall, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Systems Neuroscience A

  9682, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Primate Systems Neuroscience D

  9685, Fall, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamental Primate Neuroscience I

  9641, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Systems Neuroscience C

  9684, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Practical on Neuroscience

  9656, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Systems Neuroscience D

  9685, Fall, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Systems Neuroscience B

  9683, Fall, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamental Primate Neuroscience II

  9642, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Interdisciplinary Seminar on Primatology

  9572, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Primate Systems Neuroscience

  9651, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Primate Systems Neuroscience A

  9682, Spring, Graduate School of Science, 2
• From Apr. 2014, To Mar. 2015

  Fundamental Primate Brain Science I

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Fundamental Primate Brain Science II

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Practice on Neuroanatomy

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Primate Systems Neuroscience IA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Primate Systems Neuroscience IB

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Primate Systems Neuroscience IIA

  Spring, 理学研究科
• From Apr. 2014, To Mar. 2015

  Seminar on Primate Systems Neuroscience IIB

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科
• From Apr. 2014, To Mar. 2015

  Introduction to Primate Brain Science

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Practical on Neuroanatomy

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Primate Systems Neuroscience IA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Primate Systems Neuroscience IB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Primate Systems Neuroscience IIA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Primate Systems Neuroscience IIB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Primate Brain Science

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Fundamental Primate Brain Science II

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Fundamental Primate Brain Science I

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Practical on Neuroscience

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Interdisciplinary Seminar on Primatology

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Fundamental Primate Neuroscience I

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Fundamental Primate Neuroscience II

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Systems Neuroscience A

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Systems Neuroscience B

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Systems Neuroscience C

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Primate Systems Neuroscience D

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Practical on Neuroscience

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Fundamental Primate Neuroscience I

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Fundamental Primate Neuroscience II

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Systems Neuroscience A

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Systems Neuroscience B

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Systems Neuroscience C

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Primate Systems Neuroscience D

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Practical on Neuroscience

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Fundamental Primate Neuroscience II

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Fundamental Primate Neuroscience I

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Systems Neuroscience A

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Systems Neuroscience B

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Systems Neuroscience C

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Primate Systems Neuroscience D

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Practical on Neuroscience

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Fundamental Primate Neuroscience II

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Fundamental Primate Neuroscience I

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Systems Neuroscience A

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Systems Neuroscience B

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Systems Neuroscience C

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Primate Systems Neuroscience D

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Practical on Neuroscience

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Fundamental Primate Neuroscience I

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Fundamental Primate Neuroscience II

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Systems Neuroscience A

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Systems Neuroscience B

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Systems Neuroscience C

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Primate Systems Neuroscience D

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Practical on Neuroscience

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Fundamental Primate Neuroscience I

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Fundamental Primate Neuroscience II

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Systems Neuroscience A

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Systems Neuroscience B

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Systems Neuroscience C

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Primate Systems Neuroscience D

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Primate Systems Neuroscience

  Fall, 理学研究科

Academic, Social Contribution

Academic Contribution

• 第5回 サル脳新技術研究会

  Planning, management, etc.

  南本 敬史、井上 謙一、雨森 賢一, From 01 Mar. 2024, To 02 Mar. 2024

  
• 第４回 サル脳新技術研究会

  Planning, management, etc.

  南本 敬史、井上 謙一、山田 洋, From 24 Feb. 2023, To 25 Feb. 2023

  
• 第3回 サル脳新技術研究会

  Planning, management, etc.

  南本 敬史、井上 謙一、武井 智彦, From 19 Feb. 2022, To 19 Feb. 2022