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Kim, Minsoo
Graduate School of Medicine Associate Professor
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Last Updated :2025/06/20
Basic Information
Faculty
Professional Memberships
- JAPANESE SOCIETY FOR BACTERIOLOGY
- THE JAPANESE BIOCHEMICAL SOCIETY
- THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
- JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
Academic Degree
Research History
- From Apr. 2015, To Mar. 2020Kyoto University, Hakubi center, 特定准教授
- From Aug. 2020, To PresentKyoto University, Graduate School of Medicine Center for Medical Education, Associate Professor
- From May 2007, To Mar. 2015Tokyo University
Language of Instruction
ID,URL
ORCID ID
J-Global ID
Website(s) (URL(s))
researchmap URL
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Last Updated :2025/06/20
Research
Research Topics, Overview of the research
Research Topics
Deciphering the “Ubiquitin codes”
Research Interests
Research Areas
Papers
- Structural insight into the recognition of the linear ubiquitin assembly complex by Shigella E3 ligase IpaH1.4/2.5Keito Hiragi; Akira Nishide; Kenji Takagi; Kazuhiro Iwai; Minsoo Kim; Tsunehiro MizushimaThe Journal of Biochemistry, 04 Jan. 2023
- Bacterial effectors and their functions in the ubiquitin-proteasome system: insight from the modes of substrate recognition.Kim M; Otsubo R; Morikawa H; Nishide A; Takagi K; Sasakawa C; Mizushima TCells, Aug. 2014, Peer-reviewed
- Active site structure of the Shigella flexneri effector OspIAkira Nishide; Kenji Takagi; Minsoo Kim; Tsunehiro Mizushima15 Feb. 2022
- Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar InflammationMinsoo KimCell Reports, 10 Sep. 2019
- Crystal structure of the substrate-recognition domain of the Shigella E3 ligase IpaH9.8Takagi, K.; Kim, M.; Sasakawa, C.; Mizushima, T.Acta Crystallographica Section:F Structural Biology Communications, 2016
- The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.Yasuhiro Fuseya; Hiroaki Fujita; Minsoo Kim; Fumiaki Ohtake; Akira Nishide; Katsuhiro Sasaki; Yasushi Saeki; Keiji Tanaka; Ryosuke Takahashi; Kazuhiro IwaiNature cell biology, Jun. 2020, Peer-reviewed
- Moyamoya disease patient mutations in the RING domain of RNF213 reduce its ubiquitin ligase activity and enhance NFκB activation and apoptosis in an AAA+ domain-dependent manner.Midori Takeda; Tohru Tezuka; Minsoo Kim; Jungmi Choi; Yuki Oichi; Hatasu Kobayashi; Kouji H Harada; Tsunehiro Mizushima; Shigeru Taketani; Akio Koizumi; Shohab YoussefianBiochemical and biophysical research communications, 02 Mar. 2020, Peer-reviewed
- Midori-ishi Cyan/monomeric Kusabira-Orange-based fluorescence resonance energy transfer assay for characterization of various E3 ligasesRyota Otsubo; Minsoo Kim; Jihye Lee; Chihiro SasakawaGENES TO CELLS, Jun. 2016, Peer-reviewed
- Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.Shiho Suzuki; Hitomi Mimuro; Minsoo Kim; Michinaga Ogawa; Hiroshi Ashida; Takahito Toyotome; Luigi Franchi; Masato Suzuki; Takahito Sanada; Toshihiko Suzuki; Hiroko Tsutsui; Gabriel Núñez; Chihiro SasakawaProc. Natl. Acad. Sci. U.S.A., Oct. 2014, Peer-reviewed
- Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages.Suzuki S; Mimuro H; Kim M; Ogawa M; Ashida H; Toyotome T; Franchi L; Suzuki M; Sanada T; Suzuki T; Tsutsui H; Núñez G; Sasakawa CProceedings of the National Academy of Sciences of the United States of America, Oct. 2014, Peer-reviewed
- Epigenetic silencing of miR-210 increases the proliferation of gastric epithelium during chronic Helicobacter pylori infectionKotaro Kiga; Hitomi Mimuro; Masato Suzuki; Aya Shinozaki-Ushiku; Taira Kobayashi; Takahito Sanada; Minsoo Kim; Michinaga Ogawa; Yuka W. Iwasaki; Hiroyuki Kayo; Yoko Fukuda-Yuzawa; Masakazu Yashiro; Masashi Fukayama; Taro Fukao; Chihiro SasakawaNATURE COMMUNICATIONS, Sep. 2014, Peer-reviewed
- Exploitation of the host ubiquitin system by human bacterial pathogensHiroshi Ashida; Minsoo Kim; Chihiro SasakawaNATURE REVIEWS MICROBIOLOGY, Jun. 2014, Peer-reviewed
- Structural Basis for the Recognition of Ubc13 by the Shigella flexneri Effector OsplAkira Nishide; Minsoo Kim; Kenji Takagi; Ai Himeno; Takahito Sanada; Chihiro Sasakawa; Tsunehiro MizushimaJOURNAL OF MOLECULAR BIOLOGY, Aug. 2013, Peer-reviewed
- The Shigella OspC3 effector inhibits caspase-4, antagonizes inflammatory cell death, and promotes epithelial infection.Kobayashi T; Ogawa M; Sanada T; Mimuro H; Kim M; Ashida H; Akakura R; Yoshida M; Kawalec M; Reichhart JM; Mizushima T; Sasakawa CCell host & microbe, May 2013, Peer-reviewed
- Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-cTakeshita Kohei; Tezuka Tohru; Isozaki Yukari; Yamashita Eiki; Suzuki Mamoru; Kim Minsoo; Yamanashi Yuji; Yamamoto Tadashi; Nakagawa AtsushiJournal of Biochemistry, Nov. 2012, Peer-reviewed
- Uptake of Shigella-containing pseudopodia by neighboring epithelial cells at tricellular junctions via non-canonical clathrin-dependent trafficking pathway.Fukumatsu M; Ogawa M; Kim M; Mimuro H; Sasakawa CVirulence, Oct. 2012, Peer-reviewed
- A bacterial effector targets the TRAF6-NFκB pathway to modulate the acute inflammatory response to bacterial invasion of epithelial cells.Sanada T; Kim M; Mimuro H; Ashida H; Ogawa M; Mizushima T; Sasakawa CVirulence, Oct. 2012, Peer-reviewed
- The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response.Sanada T; Kim M; Mimuro H; Suzuki M; Ogawa M; Oyama A; Ashida H; Kobayashi T; Koyama T; Nagai S; Shibata Y; Gohda J; Inoue J; Mizushima T; Sasakawa CNature, Mar. 2012, Peer-reviewed
- Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cellsM. Fukumatsu; M. Ogawa; S. Arakawa; M. Suzuki; K. Nakayama; S. Shimizu; M. Kim; H. Mimuro; C. SasakawaCell Host and Microbe, 2012, Peer-reviewed
- Cell death and infection: a double-edged sword for host and pathogen survival.Ashida H; Mimuro H; Ogawa M; Kobayashi T; Sanada T; Kim M; Sasakawa CThe Journal of cell biology, Dec. 2011, Peer-reviewed
- Bacteria and host interactions in the gut epithelial barrier.Ashida H; Ogawa M; Kim M; Mimuro H; Sasakawa CNature chemical biology, Dec. 2011, Peer-reviewed
- Monoubiquitination of Tob/BTG family proteins competes with degradation-targeting polyubiquitinationToru Suzuki; Minsoo Kim; Hiroko Kozuka-Hata; Masato Watanabe; Masaaki Oyama; Kouhei Tsumoto; Tadashi YamamotoBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, Peer-reviewed
- Shigella deploy multiple countermeasures against host innate immune responsesHiroshi Ashida; Michinaga Ogawa; Minsoo Kim; Shiho Suzuki; Takahito Sanada; Claire Punginelli; Hitomi Mimuro; Chihiro SasakawaCURRENT OPINION IN MICROBIOLOGY, Feb. 2011, Peer-reviewed
- Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein TobMakoto Watanabe; Toru Suzuki; Minsoo Kim; Yoshinori Abe; Yutaka Yoshida; Sumio Sugano; Tadashi YamamotoFEBS LETTERS, Jan. 2011, Peer-reviewed
- The bacterial effector Cif interferes with SCF ubiquitin ligase function by inhibiting deneddylation of Cullin1Hanako Morikawa; Minsoo Kim; Hitomi Mimuro; Claire Punginelli; Tomohiro Koyama; Shinya Nagai; Atsushi Miyawaki; Kazuhiro Iwai; Chihiro SasakawaBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2010, Peer-reviewed
- Bacterial Interactions with the Host EpitheliumMinsoo Kim; Hiroshi Ashida; Michinaga Ogawa; Yuko Yoshikawa; Hitomi Mimuro; Chihiro SasakawaCELL HOST & MICROBE, Jul. 2010, Peer-reviewed
- Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachmentMinsoo Kim; Michinaga Ogawa; Hitomi Mimuro; Chihiro SasakawaVIRULENCE, Jan. 2010, Peer-reviewed
- Reinforcement of epithelial cell adhesion to basement membrane by a bacterial pathogen as a new infectious stratagem.Kim M; Ogawa M; Mimuro H; Sasakawa CVirulence, Jan. 2010, Peer-reviewed
- A bacterial E3 ubiquitin ligase IpaH9.8 targets NEMO/IKK gamma to dampen the host NF-kappa B-mediated inflammatory responseHiroshi Ashida; Minsoo Kim; Marc Schmidt-Supprian; Averil Ma; Michinaga Ogawa; Chihiro SasakawaNATURE CELL BIOLOGY, Jan. 2010, Peer-reviewed
- Listeria monocytogenes ActA-mediated escape from autophagic recognitionYuko Yoshikawa; Michinaga Ogawa; Torsten Hain; Mitsutaka Yoshida; Makoto Fukumatsu; Minsoo Kim; Hitomi Mimuro; Ichiro Nakagawa; Toru Yanagawa; Tetsuro Ishii; Akira Kakizuka; Elizabeth Sztul; Trinad Chakraborty; Chihiro SasakawaNATURE CELL BIOLOGY, Oct. 2009, Peer-reviewed
- Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachmentMinsoo Kim; Michinaga Ogawa; Yukihiro Fujita; Yuko Yoshikawa; Takeshi Nagai; Tomohiro Koyama; Shinya Nagai; Anika Lange; Reinhard Faessler; Chihiro SasakawaNATURE, May 2009, Peer-reviewed
- A new ubiquitin ligase involved in p57(KIP2) proteolysis regulates osteoblast cell differentiationMinsoo Kim; Takashi Nakamoto; Shigeki Nishimori; Keiji Tanaka; Tomoki ChibaEMBO REPORTS, Sep. 2008, Peer-reviewed
- A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling.Iwai H; Kim M; Yoshikawa Y; Ashida H; Ogawa M; Fujita Y; Muller D; Kirikae T; Jackson PK; Kotani S; Sasakawa CCell, Aug. 2007, Peer-reviewed
- Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradationM Kim; T Tezuka; K Tanaka; T YamamotoONCOGENE, Mar. 2004, Peer-reviewed
- Molecular cloning and characterization of a novel cbl-family gene, cbl-cMinsoo Kim; Tohru Tezuka; Yutaka Suziki; Sumio Sugano; Momoki Hirai; Tadashi YamamotoGene, 18 Oct. 1999, Peer-reviewed
Misc.
- Manipulation of the host cell death pathway by ShigellaHiroshi Ashida; Minsoo Kim; Chihiro SasakawaCELLULAR MICROBIOLOGY, Dec. 2014
- 赤痢菌エフェクターIpaH4.5による細胞周期の制御メカニズム井上 正範; Kim Minsoo; 芦田 浩; 小川 道永; 笹川 千尋日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008
- The role and mechanism of p57(kip2) degradation during TGF-beta 1 signalingMinsoo Kim; Shigeki Nishimori; Yoshikazu Tanaka; Keiii Tanaka; Tomoki ChibaCELL STRUCTURE AND FUNCTION, Jun. 2005
- Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation (vol 23, pg 1645, 2003)M Kim; T Tezuka; K Tanaka; T YamamotoONCOGENE, Oct. 2004
Awards
External funds: Kakenhi
- Development of anti-inflammatory drugGrant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 54:Internal medicine of the bio-information integration and related fieldsKyoto UniversityMINSOO KIMFrom 09 Jul. 2021, To 31 Mar. 2024, Project Closed病原細菌;免疫;感染症;ケミカルバイオロジー
- Functional analysis of heritable risk factors for moyamoya disease and strokeGrant-in-Aid for Scientific Research (B)Basic Section 56010:Neurosurgery-relatedKyoto UniversityTohru TezukaFrom 01 Apr. 2020, To 31 Mar. 2023, Project Closedもやもや病;シグナル伝達;RNF213;血管閉塞性疾患;血管閉塞;細胞内シグナル
- Structural studies of infection mechanisms targeting the NF-kB pathway by pathogenic bacterial effectorsGrant-in-Aid for Scientific Research (B)Basic Section 43020:Structural biochemistry-relatedUniversity of HyogoTsunehiro MizushimaFrom 01 Apr. 2020, To 31 Mar. 2024, Project Closed蛋白質;エフェクター;構造解析;ユビキチン
- New antibiotics developmentGrant-in-Aid for Scientific Research (B)Basic Section 37030:Chemical biology-relatedKyoto UniversityMINSOO KIMFrom 01 Apr. 2020, To 31 Mar. 2024, Project Closed病原細菌;ケミカルバイオロジー;抗菌剤;蛋白質分解
- Bacteria Hijack host ubiquitin systemGrant-in-Aid for Scientific Research (C)Kyoto UniversityMinsoo KimFrom 01 Apr. 2017, To 31 Mar. 2020, Project Closed細菌感染;ユビキチン;エフェクター
- Structural biology of Shigella effectors to elucidate the molecular mechanisms of substrate recognition and infectionGrant-in-Aid for Scientific Research (B)University of HyogoTSUNEHIRO MIZUSHIMAFrom 01 Apr. 2015, To 31 Mar. 2018, Project Closedエフェクター;X線結晶構造解析;ユビキチン修飾経路;赤痢菌;ユビキチンリガーゼ;蛋白質;細菌;IpaH;Ｘ線結晶構造解析
- バクテリアが持つユビキチン修飾システムGrant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)Biological SciencesKyoto UniversityKim MinsooFrom 01 Apr. 2015, To 31 Mar. 2017, Project Closedユビキチン;エフェクター;感染制御;蛋白質;感染症;病原細菌
- 細菌病原因子と宿主標的蛋白質の相互作用基盤Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)Biological SciencesThe University of TokyoKIM MinsooFrom 01 Apr. 2013, To 31 Mar. 2015, Project Closed病原細菌;エフェクター;感染制御;X-線構造
- バクテリアが利用するユビキチンシステムGrant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)Biological SciencesThe University of TokyoKIM MinsooFrom 01 Apr. 2013, To 31 Mar. 2015, Project Closed病原細菌;エフェクター;ユビキチン;感染制御
- 病原細菌感染における宿主細胞の免疫応答解明Grant-in-Aid for JSPS FellowsThe University of Tokyo芦田 浩;KIM Minsoo;金 玟秀From 01 Apr. 2013, To 31 Mar. 2016, Project Closed赤痢菌;エフェクター;炎症;病原細菌感染
- Structural analyses of bacterial effectors and their mechanisms of infectionGrant-in-Aid for Scientific Research (B)University of HyogoTSUNEHIRO MIZUSHIMAFrom 01 Apr. 2012, To 31 Mar. 2015, Project Closedエフェクター;赤痢菌;X線結晶構造解析;ユビキチン経路;蛋白質;細菌;エフェクタータンパク質;複合体構造;OspI
- Development of new therapeutic tools against pathogenic bacteriaGrant-in-Aid for Young Scientists (A)The University of TokyoMinsoo KIMFrom 01 Apr. 2011, To 31 Mar. 2014, Project Closedエフェクター;病原細菌;阻害剤;エフェクタ-
- Analysis of host cell cycle arrest mechanism by EPEC infectionGrant-in-Aid for Young Scientists (B)The University of TokyoMinsoo KIMFrom 01 Apr. 2008, To 31 Mar. 2010, Project Closed感染免疫;細胞周期;病原性大腸菌
- International collaboration for the development of new molecular-targeted antimicrobial agentsFund for the Promotion of Joint International Research (Fostering Joint International Research (B))Medium-sized Section 54:Internal medicine of the bio-information integration and related fieldsKyoto UniversityKim MinsooFrom 07 Oct. 2022, To 31 Mar. 2026, Granted細菌感染;細胞運動;抗菌剤
list
Last Updated :2025/06/20
Education
Teaching subject(s)
- From 01 Apr. 2025, To 31 Mar. 2026ILAS Seminar-E2Z002, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026ILAS Seminar-E2Z002, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Microorganisms in our Lives-E2N943, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2025, To 31 Mar. 2026Introduction to Immunology-E2N942, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Introduction to Immunology-E2N942, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025ILAS Seminar-E2Z002, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025ILAS Seminar-E2Z002, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Microorganisms in our Lives-E2N943, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024ILAS Seminar-E2Z002, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024ILAS Seminar-E2Z002, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Microorganisms in our Lives-E2N943, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Introduction to Immunology-E2N942, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2022, To 31 Mar. 2023Microorganisms in our Lives-E2N943, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2022, To 31 Mar. 2023ILAS Seminar-E2Z002, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2022, To 31 Mar. 2023ILAS Seminar-E2Z002, Fall, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2022, To 31 Mar. 2023Introduction to Immunology-E2N942, Fall, Institute for Liberal Arts and Sciences, 2
- From Apr. 2017, To Mar. 2018ILAS SeminarSpring, 全学共通科目
- From Apr. 2017, To Mar. 2018Interdisciplinary Life Science CourseFall, 理学研究科
- From Apr. 2018, To Mar. 2019ILAS SeminarSpring, 全学共通科目
- From Apr. 2019, To Mar. 2020ILAS SeminarSpring, 全学共通科目
- From Apr. 2019, To Mar. 2020ILAS SeminarSpring, 全学共通科目
- From Apr. 2021, To Mar. 2022ILAS Seminar-E2 :It's a Bug's Life - bacteria and virusesSpring, 全学共通科目
- From Apr. 2021, To Mar. 2022ILAS Seminar-E2 :Pioneers of Medical Science - Learning from Nobel and Nobel BreakthroughsFall, 全学共通科目
- From Apr. 2021, To Mar. 2022Introduction to Immunology-E2 :The body's defense systemFall, 全学共通科目
- From Apr. 2021, To Mar. 2022Microorganisms in our Lives-E2Spring, 全学共通科目
