Basic Information

Affiliated programs (koza)

• Graduate School of Pharmaceutical Sciences, 創発医薬科学専攻 創発医薬科学講座
• Graduate School of Medicine, 医科学専攻 ケミカルバイオロジー, 教授
• Graduate School of Medicine, 医学専攻 ケミカルバイオロジー, 教授

Concurrent Affiliation

• Institute for Advanced Study, 物質－細胞統合システム拠点, 連携主任研究員

Academic Degree

• M.S.(Kyoto University)
• Ph.D(Kyoto University)

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  200901055070756320

• External link

  http://www.scl.kyoto-u.ac.jp/~uesugi/

Website(s) (URL(s))

• https://www.scl.kyoto-u.ac.jp/~uesugi/ja/index.php

researchmap URL

• https://researchmap.jp/read0122106

Research

Research Topics, Overview of the research

• Research Topics

  Chemical Biology
  Self-Assembling Matters

• Overview of the research

  Chemical biology is an interdisciplinary field of study that is often defined as "chemistry-initiated biology." As biological processes all stem from chemical events, it should be possible to understand or manipulate biological events by using chemistry. Our laboratory has been discovering or designing unique organic molecules that modulate fundamental processes in human cells. Such synthetic organic molecules often serve as tools for basic cell biology. Discovery or design of small molecules with unique biological activity permits small-molecule initiated exploration of complex cellular events. Our mission is to create new world of bioactive synthetic molecules: their new way to use, their new shapes, and their new sizes. We hope to open new avenues for small-molecule applications in a range of fields, including future concepts in drug discovery and use of small molecules for cell therapy.
  
  

Papers

• Structure-activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052

  Fumihiro Kawagoe; Sayuri Mototani; Aileen Mendoza; Yasushi Takemoto; Motonari Uesugi; Atsushi Kittaka

  RSC Medicinal Chemistry, 2023

  
• Chemoproteomic Identification of Blue-Light-Damaged Proteins

  Kohei Toh; Kosuke Nishio; Reiko Nakagawa; Syusuke Egoshi; Masahiro Abo; Amelie Perron; Shin-ichi Sato; Naoki Okumura; Noriko Koizumi; Kosuke Dodo; Mikiko Sodeoka; Motonari Uesugi

  Journal of the American Chemical Society, 28 Oct. 2022

  
• Self-assembling small-molecule adjuvants as antigen nano-carriers

  Shuyu Jin; Shao-hua Zhuo; Yasushi Takemoto; Yan-mei Li; Motonari Uesugi

  Chemical Communications, 2022

  
• 13 Regulation of Gene Transcription by Small Synthetic Molecules

  Shimogawa Hiroki; Sato Ayato; Jung Dong-Ju; Sato Shinichi; Kawazoe Yoshinori; Uesugi Motonari

  Symposium on the Chemistry of Natural Products, symposium papers, 24 Aug. 2007

  
• Magnetic Control of Cells by Chemical Fabrication of Melanin

  Kosuke Nishio; Kohei Toh; Amelie Perron; Masato Goto; Masahiro Abo; Yuichi Shimakawa; Motonari Uesugi

  Journal of the American Chemical Society, 12 Sep. 2022

  
• Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation

  Yousuke Katsuda; Shin-ichi Sato; Maimi Inoue; Hisashi Tsugawa; Takuto Kamura; Tomoki Kida; Rio Matsumoto; Sefan Asamitsu; Norifumi Shioda; Shuhei Shiroto; Yoshiki Oosawatsu; Kenji Yatsuzuka; Yusuke Kitamura; Masaki Hagihara; Toshihiro Ihara; Motonari Uesugi

  Nucleic Acids Research, 08 Jul. 2022

  
• Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis.

  Satoshi Kawamura; Yuki Matsushita; Shigeyuki Kurosaki; Mizuki Tange; Naoto Fujiwara; Yuki Hayata; Yoku Hayakawa; Nobumi Suzuki; Masahiro Hata; Mayo Tsuboi; Takahiro Kishikawa; Hiroto Kinoshita; Takuma Nakatsuka; Masaya Sato; Yotaro Kudo; Yujin Hoshida; Atsushi Umemura; Akiko Eguchi; Tsuneo Ikenoue; Yoshihiro Hirata; Motonari Uesugi; Ryosuke Tateishi; Keisuke Tateishi; Mitsuhiro Fujishiro; Kazuhiko Koike; Hayato Nakagawa

  The Journal of clinical investigation, 05 Apr. 2022

  
• Glucose as a Protein-Condensing Cellular Solute.

  Naotaka Noda; Yejin Jung; Genyir Ado; Yoshiyuki Mizuhata; Masakazu Higuchi; Tetsuya Ogawa; Fumiyoshi Ishidate; Shin-Ichi Sato; Hiroki Kurata; Norihiro Tokitoh; Motonari Uesugi

  ACS chemical biology, 18 Mar. 2022

  
• Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe.

  Yejin Jung; Naotaka Noda; Junichiro Takaya; Masahiro Abo; Kohei Toh; Ken Tajiri; Changyi Cui; Lu Zhou; Shin-Ichi Sato; Motonari Uesugi

  ACS chemical biology, 18 Feb. 2022

  
• Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells

  Genyir Ado; Naotaka Noda; Hue T. Vu; Amelie Perron; Amarjyoti D. Mahapatra; Karla Pineda Arista; Hideaki Yoshimura; Daniel M. Packwood; Fumiyoshi Ishidate; Shin-ichi Sato; Takeaki Ozawa; Motonari Uesugi

  Chemical Science, 2022

  
• Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite.

  Aileen Mendoza; Yasushi Takemoto; Kevin Tan Cruzado; Shadi Sedghi Masoud; Akiko Nagata; Ajcharapan Tantipanjaporn; Satoshi Okuda; Fumihiro Kawagoe; Ryota Sakamoto; Minami Odagi; Sayuri Mototani; Moeka Togashi; Makoto Kawatani; Harumi Aono; Hiroyuki Osada; Hayato Nakagawa; Tatsuya Higashi; Atsushi Kittaka; Kazuo Nagasawa; Motonari Uesugi

  Cell chemical biology, 07 Sep. 2021

  
• Chemical Genetics Reveals a Role of Squalene Synthase in TGFβ Signaling and Cardiomyogenesis.

  Yasushi Takemoto; Shin Kadota; Itsunari Minami; Shinya Otsuka; Satoshi Okuda; Masahiro Abo; Louvy Lynn Punzalan; Yan Shen; Yuji Shiba; Motonari Uesugi

  Angewandte Chemie (International ed. in English), 10 Aug. 2021

  
• Asian Chemical Biology Initiative (ACBI): Bringing Together Chemical Biologists Within Asia.

  Mitsue Nakashima; Motonari Uesugi

  Chembiochem : a European journal of chemical biology, 09 Jul. 2021

  
• Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo.

  Fumihiro Kawagoe; Aileen Mendoza; Yuki Hayata; Lisa Asano; Kenjiro Kotake; Sayuri Mototani; Satoshi Kawamura; Shigeyuki Kurosaki; Yusuke Akagi; Yasushi Takemoto; Kazuo Nagasawa; Hayato Nakagawa; Motonari Uesugi; Atsushi Kittaka

  Journal of medicinal chemistry, 13 May 2021

  
• Light-Controlled Tyrosine Nitration of Proteins.

  Tengfang Long; Lei Liu; Youqi Tao; Wanli Zhang; Jiale Quan; Jie Zheng; Julian D Hegemann; Motonari Uesugi; Wenbing Yao; Hong Tian; Huan Wang

  Angewandte Chemie (International ed. in English), 12 Apr. 2021

  
• ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts.

  Qin Li; Torsten B Meissner; Fang Wang; Ziming Du; Sai Ma; Sarika Kshirsagar; Tamara Tilburgs; Jason D Buenrostro; Motonari Uesugi; Jack L Strominger

  Proceedings of the National Academy of Sciences of the United States of America, 02 Mar. 2021

  
• Non-genetic cell-surface modification with a self-assembling molecular glue.

  Hayase Hakariya; Ippei Takashima; Misao Takemoto; Naotaka Noda; Shin-Ichi Sato; Motonari Uesugi

  Chemical communications (Cambridge, England), 15 Feb. 2021

  
• Discovery of Self‐Assembling Small Molecules as Vaccine Adjuvants

  Shuyu Jin; Hue Thi Vu; Kou Hioki; Naotaka Noda; Hiroki Yoshida; Toru Shimane; Shigenari Ishizuka; Ippei Takashima; Yoshiyuki Mizuhata; Kathleen Beverly Pe; Tetsuya Ogawa; Naoya Nishimura; Daniel Packwood; Norihiro Tokitoh; Hiroki Kurata; Sho Yamasaki; Ken J. Ishii; Motonari Uesugi

  Angewandte Chemie, 11 Jan. 2021

  
• Discovery of Self-Assembling Small Molecules as Vaccine Adjuvants.

  Shuyu Jin; Hue Thi Vu; Kou Hioki; Naotaka Noda; Hiroki Yoshida; Toru Shimane; Shigenari Ishizuka; Ippei Takashima; Yoshiyuki Mizuhata; Kathleen Beverly Pe; Tetsuya Ogawa; Naoya Nishimura; Daniel Packwood; Norihiro Tokitoh; Hiroki Kurata; Sho Yamasaki; Ken J Ishii; Motonari Uesugi

  Angewandte Chemie (International ed. in English), 11 Jan. 2021, Peer-reviewed

  
• Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library.

  Louvy Lynn Punzalan; Lulu Jiang; Di Mao; Amarjyoti Das Mahapatra; Shinichi Sato; Yasushi Takemoto; Mari Tsujimura; Kosuke Kusamori; Makiya Nishikawa; Lu Zhou; Motonari Uesugi

  Cell chemical biology, 28 Apr. 2020, Peer-reviewed

  
• Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule.

  Xiaodan Zhang; Lulu Jiang; Ke Huang; Chuantao Fang; Jian Li; Jintong Yang; Huiti Li; Xiaoxue Ruan; Penghui Wang; Mingguang Mo; Ping Wu; Yanhui Xu; Chao Peng; Motonari Uesugi; Deyong Ye; Fa-Xing Yu; Lu Zhou

  ACS chemical biology, 24 Feb. 2020, Peer-reviewed

  
• Discovery of a Small-Molecule-Dependent Photolytic Peptide.

  Yasushi Takemoto; Di Mao; Louvy Lynn Punzalan; Sebastian Götze; Shin-Ichi Sato; Motonari Uesugi

  Journal of the American Chemical Society, 22 Jan. 2020, Peer-reviewed

  
• Synthetic Chemical Probes That Dissect Vitamin D Activities.

  Akiko Nagata; Yusuke Akagi; Lisa Asano; Kenjiro Kotake; Fumihiro Kawagoe; Aileen Mendoza; Shadi Sedghi Masoud; Kosuke Usuda; Koji Yasui; Yasushi Takemoto; Atsushi Kittaka; Kazuo Nagasawa; Motonari Uesugi

  ACS chemical biology, 20 Dec. 2019, Peer-reviewed

  
• Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators.

  Furuta T; Mizukami Y; Asano L; Kotake K; Ziegler S; Yoshida H; Watanabe M; Sato SI; Waldmann H; Nishikawa M; Uesugi M

  ACS chemical biology, Sep. 2019, Peer-reviewed

  
• Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment

  Ippei Takashima; Kosuke Kusamori; Hayase Hakariya; Megumi Takashima; Thi Hue Vu; Yuya Mizukami; Naotaka Noda; Yukiya Takayama; Yousuke Katsuda; Shin-ichi Sato; Yoshinobu Takakura; Makiya Nishikawa; Motonari Uesugi

  ACS Chemical Biology, 19 Apr. 2019, Peer-reviewed

  
• Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics

  Kenji Yatsuzuka; Shin-ichi Sato; Kathleen Beverly Pe; Yousuke Katsuda; Ippei Takashima; Mizuki Watanabe; Motonari Uesugi

  Chemical Communications, 2018, Peer-reviewed

  
• Chemical decontamination of iPS cell-derived neural cell mixtures

  Di Mao; Xie Khim Watson Chung; Tomoko Andoh-Noda; Ying Qin; Shin-Ichi Sato; Yasushi Takemoto; Wado Akamatsu; Hideyuki Okano; Motonari Uesugi

  Chemical Communications, 2018, Peer-reviewed

  
• Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe

  Shin-ichi Sato; Kenji Yatsuzuka; Yousuke Katsuda; Motonari Uesugi

  Methods in Molecular Biology, 2018, Peer-reviewed

  
• Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone

  Amelie Perron; Yoshihiro Nishikawa; Jun Iwata; Hiromi Shimojo; Junichiro Takaya; Kumiko Kobayashi; Itaru Imayoshi; Naasson M. Mbenza; Mihoko Takenoya; Ryoichiro Kageyama; Yuzo Kodama; Motonari Uesugi

  Journal of Biological Chemistry, 2018, Peer-reviewed

  
• Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP

  Lisa Asano; Mizuki Watanabe; Yuta Ryoden; Kousuke Usuda; Takuya Yamaguchi; Bilon Khambu; Megumi Takashima; Shin-ichi Sato; Juro Sakai; Kazuo Nagasawa; Motonari Uesugi

  Cell Chemical Biology, 16 Feb. 2017, Peer-reviewed

  
• A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures

  Di Mao; Shin Ando; Shin-ichi Sato; Ying Qin; Nao Hirata; Yousuke Katsuda; Eihachiro Kawase; Ting-Fang Kuo; Itsunari Minami; Yuji Shiba; Kazumitsu Ueda; Norio Nakatsuji; Motonari Uesugi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Feb. 2017, Peer-reviewed

  
• Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP

  Lisa Asano; Mizuki Watanabe; Yuta Ryoden; Kousuke Usuda; Takuya Yamaguchi; Bilon Khambu; Megumi Takashima; Shin-ichi Sato; Juro Sakai; Kazuo Nagasawa; Motonari Uesugi

  CELL CHEMICAL BIOLOGY, Feb. 2017, Peer-reviewed

  
• Self-assembling compounds as an emerging class of bioactive small molecules

  Takashima Ippei; Uesugi Motonari

  MEDCHEM NEWS, 2017

  
• A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA

  Yousuke Katsuda; Shin-ichi Sato; Lisa Asano; Yoshitaka Morimura; Tomoyuki Furuta; Hiroshi Sugiyama; Masaki Hagihara; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2016, Peer-reviewed

  
• A Potent and Site-Selective Agonist of TRPA1

  Junichiro Takaya; Kazuhiro Mio; Takuya Shiraishi; Tatsuki Kurokawa; Shinya Otsuka; Yasuo Mori; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2015, Peer-reviewed

  
• Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions

  Prakash Parvatkar; Nobuo Kato; Motonari Uesugi; Shin-ichi Sato; Junko Ohkanda

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2015, Peer-reviewed

  
• Live-cell Imaging of Endogenous mRNAs with a Small Molecule

  S. Sato; M. Watanabe; Y. Katsuda; A. Murata; D.O. Wang; M. Uesugi

  Angewandte Chemie International Edition in English, Feb. 2015, Peer-reviewed

  
• Live-Cell Imaging of Endogenous mRNAs with a Small Molecule

  Shin-ichi Sato; Mizuki Watanabe; Yousuke Katsuda; Asako Murata; Dan Ohtan Wang; Motonari Uesugi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Feb. 2015, Peer-reviewed

  
• Synthetic Molecules that Protect Cells from Anoikis and Their Use in Cell Transplantation

  Heidie L. Frisco-Cabanos; Mizuki Watanabe; Naoki Okumura; Kosuke Kusamori; Naohiro Takemoto; Junichiro Takaya; Shin-ichi Sato; Sayumi Yamazoe; Yoshinobu Takakura; Shigeru Kinoshita; Makiya Nishikawa; Noriko Koizumi; Motonari Uesugi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Oct. 2014, Peer-reviewed

  
• Selective Elimination of Human Pluripotent Stem Cells by a Marine Natural Product Derivative

  Ting-Fang Kuo; Di Mao; Nao Hirata; Bilon Khambu; Yasuhisa Kimura; Eihachiro Kawase; Hiroki Shimogawa; Makoto Ojika; Norio Nakatsuji; Kazumitsu Ueda; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2014, Peer-reviewed

  
• A Chemical Probe that Labels Human Pluripotent Stem Cells

  Nao Hirata; Masato Nakagawa; Yuto Fujibayashi; Kaori Yamauchi; Asako Murata; Itsunari Minami; Maiko Tomioka; Takayuki Kondo; Ting-Fang Kuo; Hiroshi Endo; Haruhisa Inoue; Shin-ichi Sato; Shin Ando; Yoshinori Kawazoe; Kazuhiro Aiba; Koh Nagata; Eihachiro Kawase; Young-Tae Chang; Hirofumi Suemori; Koji Eto; Hiromitsu Nakauchi; Shinya Yamanaka; Norio Nakatsuji; Kazumitsu Ueda; Motonari Uesugi

  CELL REPORTS, Mar. 2014, Peer-reviewed

  
• VMAT2 identified as a regulator of late-stage beta-cell differentiation

  Daisuke Sakano; Nobuaki Shiraki; Kazuhide Kikawa; Taiji Yamazoe; Masateru Kataoka; Kahoko Umeda; Kimi Araki; Di Mao; Shirou Matsumoto; Naomi Nakagata; Olov Andersson; Didier Stainier; Fumio Endo; Kazuhiko Kume; Motonari Uesugi; Shoen Kume

  NATURE CHEMICAL BIOLOGY, Feb. 2014, Peer-reviewed

  
• Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine a

  Masaki Kita; Yuichiro Hirayama; Kozo Yoneda; Kota Yamagishi; Takumi Chinen; Takeo Usui; Eriko Sumiya; Motonari Uesugi; Hideo Kigoshi

  Journal of the American Chemical Society, 04 Dec. 2013, Peer-reviewed

  
• Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion

  Naohiro Takemoto; Tetsuya Suehara; Heidie L. Frisco; Shin-ichi Sato; Takuhito Sezaki; Kosuke Kusamori; Yoshinori Kawazoe; Sun Min Park; Sayumi Yamazoe; Yoshiyuki Mizuhata; Rintaro Inoue; Gavin J. Miller; Steen U. Hansen; Gordon C. Jayson; John M. Gardiner; Toshiji Kanaya; Norihiro Tokitoh; Kazumitsu Ueda; Yoshinobu Takakura; Noriyuki Kioka; Makiya Nishikawa; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2013, Peer-reviewed

  
• Merging Chemistry and Biology in Emerging Countries

  Takayoshi Suzuki; Midori A. Arai; Mitsue Nakashima; Motonari Uesugi

  CHEMISTRY & BIOLOGY, Apr. 2013, Peer-reviewed

  
• Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule

  Dongju Jung; Lutfi Abu-Elheiga; Rie Ayuzawa; Ziwei Gu; Takashi Shirakawa; Yukio Fujiki; Norio Nakatsuji; Salih J. Wakil; Motonari Uesugi

  BIOCHEMICAL JOURNAL, Dec. 2012, Peer-reviewed

  
• A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions

  Itsunari Minami; Kohei Yamada; Tomomi G. Otsuji; Takuya Yamamoto; Yan Shen; Shinya Otsuka; Shin Kadota; Nobuhiro Morone; Maneesha Barve; Yasuyuki Asai; Tatyana Tenkova-Heuser; John E. Heuser; Motonari Uesugi; Kazuhiro Aiba; Norio Nakatsuji

  CELL REPORTS, Nov. 2012, Peer-reviewed

  
• Two Days of Experiments in Vietnam: Asian Chemical Biology Initiative, Hanoi Meeting

  Takashii Morii; Motonari Uesugi

  ACS CHEMICAL BIOLOGY, Apr. 2012, Peer-reviewed

  
• Translational repression stabilizes messenger RNA of autophagy-related genes

  Bilon Khambu; Motonari Uesugi; Yoshinori Kawazoe

  GENES TO CELLS, Aug. 2011, Peer-reviewed

  
• Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins

  Shinji Kamisuki; Takashi Shirakawa; Akira Kugimiya; Lutfi Abu-Elheiga; Hea-Young Park Choo; Kohei Yamada; Hiroki Shimogawa; Salih J. Wakil; Motonari Uesugi

  JOURNAL OF MEDICINAL CHEMISTRY, Jul. 2011, Peer-reviewed

  
• Cell-Morphology Profiling of a Natural Product Library Identifies Bisebromoamide and Miuraenamide A as Actin Filament Stabilizers

  Eriko Sumiya; Hiroki Shimogawa; Hiroaki Sasaki; Masato Tsutsumi; Ken'ichi Yoshita; Makoto Ojika; Kiyotake Suenaga; Motonari Uesugi

  ACS CHEMICAL BIOLOGY, May 2011, Peer-reviewed

  
• Deactivation of STAT6 through Serine 707 Phosphorylation by JNK

  Takashi Shirakawa; Yoshinori Kawazoe; Tomoko Tsujikawa; Dongju Jung; Shin-ichi Sato; Motonari Uesugi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2011, Peer-reviewed

  
• Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin

  Shin-ichi Sato; Asako Murata; Tsubasa Orihara; Takashi Shirakawa; Kiyotake Suenaga; Hideo Kigoshi; Motonari Uesugi

  CHEMISTRY & BIOLOGY, Jan. 2011, Peer-reviewed

  
• A Mitochondrial Surface-Specific Fluorescent Probe Activated by Bioconversion

  Yoshinori Kawazoe; Hiroki Shimogawa; Ayato Sato; Motonari Uesugi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• Small-molecule fluorescent probes for specific RNA targets

  Asako Murata; Shin-ichi Sato; Yoshinori Kawazoe; Motonari Uesugi

  CHEMICAL COMMUNICATIONS, 2011, Peer-reviewed

  
• Morphology-Based Screening for the Identification of Actin Targeting Compounds

  Sumiya Eriko; Shimogawa Hiroki; Sasaki Hiroaki; Ojika Makoto; Suenaga Kiyotake; Uesugi Motonari

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2010

  
• Biochemical Target Isolation for Novices: Affinity-Based Strategies

  Shin-ichi Sato; Asako Murata; Takashi Shirakawa; Motonari Uesugi

  CHEMISTRY & BIOLOGY, Jun. 2010, Peer-reviewed

  
• A Small Molecule That Blocks Fat Synthesis By Inhibiting the Activation of SREBP

  Shinji Kamisuki; Qian Mao; Lutfi Abu-Elheiga; Ziwei Gu; Akira Kugimiya; Youngjoo Kwon; Tokuyuki Shinohara; Yoshinori Kawazoe; Shin-ichi Sato; Koko Asakura; Hea-Young Park Choo; Juro Sakai; Salih J. Wakil; Motonari Uesugi

  CHEMISTRY & BIOLOGY, Aug. 2009, Peer-reviewed

  
• A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth

  Sayumi Yamazoe; Hiroki Shimogawa; Shin-ichi Sato; Jeffrey D. Esko; Motonari Uesugi

  CHEMISTRY & BIOLOGY, Jul. 2009, Peer-reviewed

  
• Wrenchnolol Derivative Optimized for Gene Activation in Cells

  Dongju Jung; Hiroki Shimogawa; Youngjoo Kwon; Qian Mao; Shin-ichi Sato; Shinji Kamisuki; Hideo Kigoshi; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2009, Peer-reviewed

  
• Polyproline-rod approach to isolating protein targets of bioactive small molecules: Isolation of a new target of indomethacin

  Shin-ichi Sato; Youngjoo Kwon; Shinji Kamisuki; Neeta Srivastava; Qian Mao; Yoshinori Kawazoe; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2007, Peer-reviewed

  
• Small organic molecules that modulate gene transcription

  DJ Jung; YM Choi; M Uesugi

  DRUG DISCOVERY TODAY, May 2006, Peer-reviewed

  
• Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2

  YM Choi; H Shimogawa; K Murakami; L Ramdas; W Zhang; J Qin; M Uesugi

  CHEMISTRY & BIOLOGY, Mar. 2006, Peer-reviewed

  
• Small molecule transcription factor mimic

  Y Kwonj; HD Arndt; M Qian; Y Choi; Y Kawazoe; PB Dervan; M Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2004, Peer-reviewed

  
• Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis

  Y Kawazoe; S Tanaka; M Uesugi

  CHEMISTRY & BIOLOGY, Jul. 2004, Peer-reviewed

  
• A wrench-shaped synthetic molecule that modulates a transcription factor - Coactivator interaction

  H Shimogawa; Y Kwon; Q Mao; Y Kawazoe; Y Choi; S Asada; H Kigoshi; M Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2004, Peer-reviewed

  
• A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction

  S Asada; YM Choi; M Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2003, Peer-reviewed

  
• Identification of bioactive molecules by adipogenesis profiling of organic compounds

  YM Choi; Y Kawazoe; K Murakami; H Misawa; M Uesugi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2003, Peer-reviewed

  
• External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator

  Shinichi Asada; Yongmun Choi; Masaki Yamada; Shao-Chun Wang; Mien-Chie Hung; Jun Qin; Motonari Uesugi

  Proceedings of the National Academy of Sciences, Oct. 2002, Peer-reviewed

  
• Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21

  Jabbur, JR; AD Tabor; XD Cheng; H Wang; M Uesugi; G Lozano; W Zhang

  ONCOGENE, Oct. 2002, Peer-reviewed

  
• Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex

  D Skowyra; M Zeremski; N Neznanov; MY Li; YM Choi; M Uesugi; CA Hauser; W Gu; AV Gudkov; J Qin

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2001, Peer-reviewed

  
• A second calcineurin binding site on the NFAT regulatory domain

  Sheldon Park; Motonari Uesugi; Gregory L. Verdine

  Proceedings of the National Academy of Sciences, 20 Jun. 2000, Peer-reviewed

  
• Divergent hTAF(II)31-binding motifs hidden in activation domains

  Y Choi; S Asada; M Uesugi

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2000, Peer-reviewed

  
• The α-helical FXXΦΦ motif in p53: TAF interaction and discrimination by MDM2

  Motonari Uesugi; Gregory L. Verdine

  Proceedings of the National Academy of Sciences, 21 Dec. 1999, Peer-reviewed

  
• A nonnatural transcriptional coactivator

  Origène Nyanguile; Motonari Uesugi; David J. Austin; Gregory L. Verdine

  Proceedings of the National Academy of Sciences, 09 Dec. 1997, Peer-reviewed

  
• Induced alpha helix in the VP16 activation domain upon binding to a human TAF.

  M Uesugi; O Nyanguile; H Lu; A J Levine; G L Verdine

  Science (New York, N.Y.), 29 Aug. 1997, Peer-reviewed

  
• SEQUENCE PREFERENCE FOR STRAND CLEAVAGE OF GAPPED DUPLEXES BY DYNEMICIN-A - POSSIBLE MECHANISM OF SEQUENCE-DEPENDENT DOUBLE-STRANDED BREAKS

  T KUSAKABE; M UESUGI; Y SUGIURA

  BIOCHEMISTRY, Aug. 1995, Peer-reviewed

  
• HYDROPHOBIC DNA-BINDING OF ESPERAMICIN REQUIRES CONFORMATIONAL DISTORTION OF THE HOST DNA

  M UESUGI; T KUSAKABE; Y SUGIURA

  BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, Mar. 1995, Peer-reviewed

  
• RNA CLEAVAGE BY C-1027 CHROMOPHORE, AN ENEDIYNE ANTITUMOR ANTIBIOTIC - HIGH SELECTIVITY TO AN ANTICODON ARM

  R TOTSUKA; Y AIZAWA; M UESUGI; Y OKUNO; T MATSUMOTO; Y SUGIURA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 1995, Peer-reviewed

  
• DNA-DAMAGE BY PTAQUILOSIDE, A POTENT BRACKEN CARCINOGEN - DETECTION OF SELECTIVE STRAND BREAKS AND IDENTIFICATION OF DNA CLEAVAGE PRODUCTS

  T KUSHIDA; M UESUGI; Y SUGIURA; H KIGOSHI; H TANAKA; J HIROKAWA; M OJIKA; K YAMADA

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 1994, Peer-reviewed

  
• CONFORMATION-SELECTIVE DNA STRAND BREAKS BY DYNEMICIN - A MOLECULAR WEDGE INTO FLEXIBLE REGIONS OF DNA

  T KUSAKABE; K MAEKAWA; A ICHIKAWA; M UESUGI; Y SUGIURA

  BIOCHEMISTRY, Nov. 1993, Peer-reviewed

  
• NEW INSIGHTS INTO SEQUENCE RECOGNITION PROCESS OF ESPERAMICIN-A(1) AND CALICHEAMICIN-GAMMA-1(I) - ORIGIN OF THEIR SELECTIVITIES AND INDUCED FIT MECHANISM

  M UESUGI; Y SUGIURA

  BIOCHEMISTRY, May 1993, Peer-reviewed

  
• SYNTHESIS OF A HYBRID MOLECULE CONTAINING NEOCARZINOSTATIN CHROMOPHORE ANALOG AND MINOR GROOVE BINDER

  M TOKUDA; K FUJIWARA; T GOMIBUCHI; M HIRAMA; M UESUGI; Y SUGIURA

  TETRAHEDRON LETTERS, Jan. 1993, Peer-reviewed

  
• C-1' HYDROGEN ABSTRACTION OF DEOXYRIBOSE IN DNA STRAND SCISSION BY DYNEMICIN-A

  T SHIRAKI; M UESUGI; Y SUGIURA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 1992, Peer-reviewed

  
• PRODUCT ANALYSES IN DNA STRAND SCISSION BY ANTITUMOR ANTIBIOTIC ELSAMICIN-A

  M UESUGI; Y SUGIURA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1992, Peer-reviewed

  
• MAN-DESIGNED BLEOMYCINS - SIGNIFICANCE OF THE BINDING-SITES AS ENZYME MODELS AND OF THE STEREOCHEMISTRY OF THE LINKER MOIETY

  T OWA; A HAUPT; M OTSUKA; S KOBAYASHI; N TOMIOKA; A ITAI; M OHNO; T SHIRAKI; M UESUGI; Y SUGIURA; K MAEDA

  TETRAHEDRON, Feb. 1992, Peer-reviewed

  
• SYNTHESIS AND DNA-CLEAVING ABILITIES OF FUNCTIONAL NEOCARZINOSTATIN CHROMOPHORE ANALOGS - BASE DISCRIMINATION BY A SIMPLE ALCOHOL

  M HIRAMA; T GOMIBUCHI; K FUJIWARA; Y SUGIURA; M UESUGI

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 1991, Peer-reviewed

  
• SELECTIVE DNA CLEAVAGE BY ELSAMICIN-A AND SWITCH FUNCTION OF ITS AMINO SUGAR GROUP

  M UESUGI; T SEKIDA; S MATSUKI; Y SUGIURA

  BIOCHEMISTRY, Jul. 1991

  
• REDUCTIVE AND NUCLEOPHILIC ACTIVATION PRODUCTS OF DYNEMICIN-A WITH METHYL THIOGLYCOLATE - A RATIONAL MECHANISM FOR DNA CLEAVAGE OF THE THIOL-ACTIVATED DYNEMICIN-A

  Y SUGIURA; T ARAKAWA; M UESUGI; T SHIRAKI; H OHKUMA; M KONISHI

  BIOCHEMISTRY, Mar. 1991, Peer-reviewed

  
• Small Molecule Tools for Cell Biology and Cell Therapy

  Uesugi, M

  Chembiomolecular Science at the Frontier of Chemistry and Biology , 51-58

  

Books and Other Publications

• ケミカルバイオロジー化合物集 研究展開のヒント

  日本学術振興会ケミカルバイオロジ; 委員会, Others, ミトコンドリア内膜のプロヒビチン１を標的とする海洋天然物

  オーム社, Oct. 2018, Not refereed

  Find Kyoto University's collection of books :

  
• 京都大学 アイデアが湧いてくる講義 サイエンスの発想法

  上杉 志成, Single work

  祥伝社黄金文庫, Sep. 2017, Not refereed

  
• 京都大学人気講義 サイエンスの発想法

  上杉志成, Single work

  祥伝社, 30 Apr. 2014, Not refereed

  
• ケミカルバイオロジー

  長野 哲雄; 菊地 和也; 上杉 志成; 長田 裕之, Joint editor

  共立出版, May 2008, Not refereed

  Find Kyoto University's collection of books :

  
• ケミカルバイオロジー PNE 蛋白質 核酸 酵素 2007年10月号増刊

  長野哲雄; 長田裕之; 菊地和也; 上杉志成; 共立出版, Joint work

  共立出版, 2007, Not refereed

  
• ゲノムサイエンスの新たなる挑戦 PNE 蛋白質 核酸 酵素 2001年12月号増刊

  長野哲雄; 長田裕之; 菊地和也; 上杉志成; 共立出版, Joint work

  共立出版, 2001, Not refereed

  

Awards

• Jul. 2001

  Young Investigator Award, Lymphoma Research Foundation
• Jul. 2003

  American Cancer Society, Research Scholar Award
• Apr. 2006

  Tokyo Techno-Forum, Gold Medal Award
• Mar. 2011

  The Pharmaceutical Society of Japan, Award for Divisional Scientific Promotions
• May 2011

  German Research and Innovation Forum Tokyo & German Chamber of Commerce and Industry in Japan, German Innovation Award Gottfried Wagener Prize 2010 (1st Prize) 
• 26 Apr. 2017

  The New Technology Development Foundation, The 49th Ichimura Prize in Science for Distinguished Achievement

External funds: Kakenhi

• Designer Melanin for Analyzing and Controlling Cells

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  上杉 志成

  From 09 Jul. 2021, To 31 Mar. 2023, Granted

  ケミカルバイオロジー;メラニン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19045/
• Exploration of Self-Assembling Bioactive Small Molecules

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  Motonari Uesugi

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  自己集合;生理活性小分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H00922/
• Synthetic post-translational modifications

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyoto University

  Motonari Uesugi

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  ケミカルバイオロジー;化合物ライブラリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19197/
• Chemical signals of synthetic nutrient conjugates

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  Motonari Uesugi

  From 30 Jun. 2017, To 31 Mar. 2022, Project Closed

  ケミカルバイオロジー;化合物ライブラリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06408/
• Frontiers in Chemical Communications

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  Hideaki Kakeya

  From 30 Jun. 2017, To 31 Mar. 2022, Project Closed

  化学コミュニケーション;分子社会学;天然物化学;ケミカルバイオロジー;生物活性リガンド

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-17H06400/
• Creating Chemical Tools that Enable Investigation and Identification of RNA G-Quadruplexes

  Grant-in-Aid for JSPS Fellows

  Kyoto University

  From 07 Oct. 2016, To 31 Mar. 2018, Discontinued

  RNA G-Quadruplexes;ケミカルバイオロジー;RNAバイオロジー;構造・活性相関研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16F16345/
• Discovery of novel RNA G-quadruplex ligands from a chemical library

  Grant-in-Aid for Young Scientists (B)

  Kumamoto University;Kyoto University

  Yousuke KATSUDA

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  RNA G-quadrupelx;translation;screening;RNA G-quadruplex;Translation;スクリーニング;タンパク質翻訳反応制御;核酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K17883/
• Development of the efficient cardiac differentiation method of pluri-poteint stem cells by using novel chemicals

  Grant-in-Aid for Scientific Research (C)

  Osaka University;Kyoto University

  Itsunari Minami

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  低分子化合物;心筋分化誘導;多能性幹細胞;臨床応用;心筋細胞;細胞凍結法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08270/
• Small molecules that control Hes1 oscillation

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Motonari Uesugi

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  化学プローブ;ケミカルバイオロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26560445/
• Structure and dynamics of intermediate filament proteins

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Sumio Terada

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  細胞骨格;中間径フィラメント;細胞学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293038/
• Control and Analysis of Cells by Synthetic Small Molecules

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Motonari Uesugi

  From 30 May 2014, To 31 Mar. 2019, Project Closed

  ケミカルバイオロジー;化学プローブ;細胞治療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26220206/
• 脂質関連内因性分子の新機能発掘と調節

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  上杉 志成

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  ケミカルバイオロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26102728/
• Elucidation of signals and metabolic bases that regulate functions of plasma membrane microdomains

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo;Nagoya University

  Yoshio Yamauchi

  From 01 Apr. 2013, To 31 Mar. 2017, Project Closed

  膜ドメイン;脂質代謝;シグナル;がん;シグナル伝達;コレステロール;スフィンゴ糖脂質;代謝;mTOR;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460385/
• Molecular mechanism of ABC proteins involved in cholesterol homeostasis

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazumitsu Ueda

  From 31 May 2013, To 31 Mar. 2018, Project Closed

  ABC蛋白質;トランスポーター;コレステロール;動脈硬化;アルツハイマー病;増殖シグナル;結晶構造解析;iPS細胞;神経細胞;1分子生物学;構造生物学;膜環境;多能性幹細胞;阻害剤;中枢神経細胞;3次元構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25221203/
• Study on Molecular Mechanism of Cytotoxicity of Marine Natural Products

  Grant-in-Aid for Scientific Research (B)

  University of Tsukuba

  Hideo KIGOSHI

  From 18 Nov. 2011, To 31 Mar. 2014, Project Closed

  アプリロニンＡ;アクチン;チューブリン;海洋天然物;三元複合体;アポトーシス;ビセライドＡ;全合成;アプリロニンA;ハテルマライト;ビセライト;脱重合;ハテルマライド;ビセライド;アクチン関連タンパク質;オーリライド;プロヒビチン;アリル酸化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23310148/
• Epigenetic plasticity as a novel target for cancer treatment

  Grant-in-Aid for Scientific Research (B)

  Aichi Cancer Center Research Institute

  Yutaka KONDO

  From 01 Apr. 2010, To 31 Mar. 2014, Project Closed

  分子標的治療;がん幹細胞;ポリコーム;グリオブラストーマ;エピジェネティクス;ポリコーム複合体;ヒストン修飾;脳腫瘍

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300344/
• 小分子有機化合物を起爆剤とした細胞シグナル解析

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  上杉 志成

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  ケミカルバイオロジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21310140/
• Physiological substrates and functions of ABC proteins involved in lipid transport

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazumitsu UEDA

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  動物生化学;膜輸送タンパク質;ABC蛋白質;動脈硬化;アルツハイマー病;コレステロール;膜タンパク質;神経疾患;生活習慣病;1分子イメージング;ABCタンパク質;善玉コレステロール;ケミカルライブラリー;iPS細胞;ES細胞;1分子観察;トランスポーター;核内受容体;蛋白質相互作用;ACBタンパク質;アルツハイマー;タンパク質精製;プロテアソーム;遺伝病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20228001/
• Small molecule analysis of cell signaling

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Motonari UESUGI

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  ケミカルバイオロジー;ケミカルジェネティクス;生理活性小分子化合物;肝臓がん;脂肪合成;標的タンパク質, Chemical Biology;Chemical genetics;bioactive small molecules;protein target;liver cancer;fat synthesis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390002/
• 標的タンパク質精製法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Kyoto University

  上杉 志成

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  ケミカルバイオロジー;ケミカルジェネティクス;生理活性小分子化合物;ビオチン;標的タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18032042/
• Chemical biology of cellular self-assemblies

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  上杉 志成

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  ケミカルバイオロジー;自己集合;生理活性化合物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00350/
• Development of Artificial Chaperones

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (II)

  Kyoto University

  上杉 志成

  From 16 Jun. 2022, To 31 Mar. 2024, Granted

  シャペロン;自己集合

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H05417/
• Intracellular Analysis of LLPS Status

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  上杉 志成

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  ケミカルバイオロジー;液-液相分離

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K17978/

External funds: others

• 次世代ケミカルバイオロジーアジア拠点 (2022年度分)

  Japan Society for the Promotion of Science (JSPS), 研究拠点形成事業　B.アジア・アフリカ学術基盤形成型

  From 01 Apr. 2022, To 31 Mar. 2023

  代表者
• 協調型アジアケミカルバイオロジー拠点 (2021年度分)

  Japan Society for the Promotion of Science (JSPS), 研究拠点形成事業　B.アジア・アフリカ学術基盤形成型

  From 01 Apr. 2021, To 31 Mar. 2022

  代表者
• 生命現象分析のための小分子転写因子創成

  独立行政法人科学技術振興機構 戦略的創造研究推進事業　さきがけ

  From Oct. 2005, To Mar. 2009

  上杉　志成
• 細胞接着促進化合物の実用化

  独立行政法人科学技術振興機構 研究成果最適展開支援事業（A-STEP）フィージビリティスタディ

  From 01 Nov. 2009, To 31 Oct. 2010

  上杉　志成
• Control and Analysis of Cells by Synthetic Small Molecules

  独立行政法人日本学術振興会 最先端・次世代研究開発支援プログラム

  From Feb. 2011, To 31 Mar. 2014

  上杉 志成
• Asian Chemical Biology Initiative

  独立行政法人日本学術振興会 アジア研究教育拠点事業

  From 01 Apr. 2011, To 31 Mar. 2016

  上杉　志成
• Chemical biological exploration of new functions of endogenous lipid-related molecules

  独立行政法人科学技術振興機構　戦略的創造研究推進事業CREST

  From 01 Oct. 2014, To 31 Mar. 2015

  上杉　志成
• Chemical biological exploration of new functions of endogenous lipid-related molecules

  国立研究開発法人日本医療研究開発機構(AMED) 革新的先端研究開発支援事業 ユニットタイプ「疾患における代謝産物の解析および代謝制御に基づく革新的医療基盤技術の創出」

  From 01 Apr. 2015, To 31 Mar. 2020

  上杉　志成
• 転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」(H26年度分)

  文部科学省

  From 21 Dec. 2014, To 31 Mar. 2015

  上杉　志成
• 転写機能をターゲットとした創薬「転写を標的とした革新的抗がん化合物シーズ」 (H27年度分)

  国立研究開発法人日本医療研究開発機構(AMED) 次世代がん研究シーズ戦略的育成プログラム　革新的がん医療シーズ育成領域

  From 01 Apr. 2015, To 31 Mar. 2016

  上杉 志成
• アドヘサミンの応用開拓研究

  独立行政法人　科学技術振興機構 シーズ発掘試験研究

  From 12 Aug. 2008, To 31 Mar. 2009

  上杉　志成
• アジア発ケミカルバイオロジー （平成27年度分）

  アジア研究教育拠点事業

  From 01 Apr. 2015, To 31 Mar. 2016

  上杉　志成
• ケミカルバイオロジー戦略的アジア拠点 （平成28年度分）

  研究拠点形成事業　B.アジア・アフリカ学術基盤形成型

  From 01 Apr. 2016, To 31 Mar. 2017

  上杉　志成
• ケミカルバイオロジー戦略的アジア拠点 （平成29年度分）

  研究拠点形成事業　B.アジア・アフリカ学術基盤形成型

  From 01 Apr. 2017, To 31 Mar. 2018

  上杉 志成
• ケミカルバイオロジー戦略的アジア拠点 （平成30年度分）

  研究拠点形成事業　B.アジア・アフリカ学術基盤形成型

  From 01 Apr. 2018, To 31 Mar. 2019

  上杉 志成
• 協調型アジアケミカルバイオロジー拠点 （2019年度分）

  研究拠点形成事業　B.アジア・アフリカ学術基盤形成型

  From 01 Apr. 2019, To 31 Mar. 2020

  上杉　志成
• 協調型アジアケミカルバイオロジー拠点 （2020年度分）

  研究拠点形成事業　B.アジア・アフリカ学術基盤形成型

  From 01 Apr. 2020, To 31 Mar. 2021

  上杉　志成

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Organic Chemistry of Life

  N324, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Organic Chemistry for Drug Discovery A

  8203, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Organic Chemistry of Life (Flipped Class)

  C019, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Organic Chemistry I

  1209, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences I

  6005, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Organic Chemistry of Life (Flipped Class)

  C019, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Organic Chemistry of Life

  N324, Spring, Institute for Liberal Arts and Sciences, 2
• From Apr. 2011, To Mar. 2012

  The Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  The Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Integrated Cell-Material Sciences

  Fall, 全学共通科目
• From Apr. 2013, To Mar. 2014

  The Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  The Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Frontier in Life Sciences

  Year-long, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  The Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Organic Chemistry of Life

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Organic Chemistry of Life (Flipped Class)

  Fall, 薬学部

Participation in PhD Defense

• Pluripotent stem cell-based screening identifies CUDC-907 as an effective compound for restoring the in vitro phenotype of Nakajo-Nishimura syndrome

  KASE NAOYA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction　Communication in Urothelial Cells

  KONO JIN, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• A drug repurposing study based on clinical big data for the protective role of vitamin D in olanzapine-induced dyslipidemia

  ZHOU ZIJIAN, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• Quantitative autoradiography in boron neutron capture therapy considering the particle ranges in the samples

  TAKENO SATOSHI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Perampanel Inhibits α-Synuclein Transmission in Parkinson’s Disease Models

  UEDA JUN, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Orthogonal Protein-Responsive mRNA Switches for Mammalian Synthetic Biology

  ONO HIROKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency

  HONDA YOSHITAKA, Graduate School of Medicine, Sub-chief Examiner

  24 May 2021
• Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies

  KITA YUKI, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2021

Administration

School management (title, position)

• From 11 Oct. 2022

  国際卓越研究大学構想検討委員会　研究等体制強化計画検討タスクフォース 委員
• From 01 Oct. 2022, To 30 Sep. 2024

  戦略調整会議 委員
• From 01 Apr. 2022, To 30 Sep. 2022

  国際戦略本部運営協議会 On-site Laboratory専門部会 部会員
• From 10 Dec. 2020, To 30 Sep. 2022

  国際戦略本部運営協議会　全学海外拠点運営専門部会 部会員
• From 01 Oct. 2020, To 30 Sep. 2022

  戦略調整会議 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  理事補
• From 28 Oct. 2020, To 30 Sep. 2022

  研究戦略タスクフォース プログラムディレクター
• From 01 Oct. 2020, To 30 Sep. 2022

  研究倫理・安全推進委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  全学共用スペース有効活用専門委員会 委員
• From 01 Feb. 2022, To 30 Jun. 2022

  戦略調整会議研究戦略・人材育成検討委員会 委員
• From 01 Oct. 2020, To 31 Mar. 2022

  戦略調整会議若手大学院生リクルーティング促進策小委員会 委員
• From 01 Oct. 2020, To 31 Mar. 2022

  戦略調整会議若手研究者リクルーティング促進策小委員会 委員
• From 01 Jun. 2021, To 31 Mar. 2022

  戦略調整会議研究支援体制の再構築（技術職員）小委員会 委員

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  物質－細胞統合システム拠点 拠点長
• From 01 Apr. 2022, To 31 Mar. 2023

  化学研究所建物管理委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2023

  化学研究所広報委員会委員長
• From 01 Apr. 2022, To 31 Mar. 2023

  化学研究所将来問題・研究活性化委員会 委員
• From 25 Nov. 2011, To 24 Nov. 2015

  ケミカルスクリーニングセンター長
• From 01 Jan. 2013, To 31 Mar. 2017

  物質－細胞統合システム拠点副拠点長
• From 01 Apr. 2017, To 31 Mar. 2018

  化学研究所運営委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2018

  化学研究所広報委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2018

  化学研究所将来問題・研究活性化委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2018

  物質－細胞統合システム拠点連携主任研究者・副拠点長
• From 01 Apr. 2018, To 31 Mar. 2020

  化学研究所ゲノムネット推進室運営委員会 委員
• From 01 Apr. 2018, To 31 Mar. 2019

  化学研究所広報委員会 委員長
• From 01 Apr. 2018, To 31 Mar. 2019

  化学研究所将来問題・研究活性化委員会 委員
• From 01 Apr. 2018, To 31 Mar. 2019

  物質－細胞統合システム拠点連携主任研究者・副拠点長
• From 01 Apr. 2019, To 31 Mar. 2020

  化学研究所広報委員会 委員長
• From 01 Apr. 2019, To 31 Mar. 2020

  化学研究所将来問題・研究活性化委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2020

  物質－細胞統合システム拠点連携主任研究者・副拠点長
• From 01 Apr. 2020, To 31 Mar. 2021

  化学研究所広報委員会委員長
• From 01 Apr. 2020, To 31 Mar. 2021

  化学研究所財務委員会委員
• From 01 Apr. 2020, To 31 Mar. 2021

  化学研究所情報セキュリティ委員会委員
• From 01 Apr. 2021, To 31 Mar. 2023

  物質－細胞統合システム拠点　副拠点長
• From 01 Apr. 2021, To 30 Sep. 2022

  白眉センター伯楽会議　委員
• From 01 Apr. 2021, To 31 Mar. 2022

  化学研究所財務委員会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  化学研究所広報委員会委員長
• From 01 Apr. 2021, To 31 Mar. 2023

  化学研究所ゲノムネット推進室運営委員会委員