Basic Information

Affiliated programs (koza)

• Graduate School of Pharmaceutical Sciences, 薬科学専攻 生体機能化学講座, 准教授

Professional Memberships

• 日本薬学会
• RNA Society
• 日本時間生物学会
• 日本生化学会

Academic Degree

• 修士（薬学）(京都大学)
• 博士（薬学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院薬学研究科修士課程生命薬科学専攻, 修了
• 京都大学, 大学院薬学研究科博士後期課程生命薬科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 薬学部薬学科, 卒業

Language of Instruction

• Japanese

ID,URL

• J-Global ID

  200901030070743706

• External link

  http://www.scl.kyoto-u.ac.jp/~bfdc/index.html

researchmap URL

• https://researchmap.jp/mikiimanishi

Research

Research Topics, Overview of the research

• Research Topics

  Design of artificial DNA/RNA binding proteins towards regulation of cellular events

• Overview of the research

  I am working on creating biomolecular tools acting on DNA or RNA to manipulate specific gene expression and to elucidate the mechanisms of biological events. Current themes include (1) Design of DNA or RNA binding proteins targeting specific sequences, (2) Control and/or detection of epigenetic modifications of DNA and RNA and (3) Elucidation of the mechanism of circadian clock.

Research Interests

• 生体機能化学
• biofunctional chemistry

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development

Papers

• Identification of Endogenous Sequences Interacting with METTL3/METTL14 RNA Methyltransferase

  Tamaki Endoh; Yiwei Ling; Shujiro Okuda; Miki Imanishi

  ChemBioChem, 14 Apr. 2025

  
• Highly sequence-specific, timing-controllable m6A demethylation by modulating RNA-binding affinity of m6A erasers

  Kenko Otonari; Yuri Asami; Kosuke Ogata; Yasushi Ishihama; Shiroh Futaki; Miki Imanishi

  Chemical Communications, 2025

  
• Mechanisms and Strategies for Determining m6A RNA Modification Sites by Natural and Engineered m6A Effector Proteins

  Miki Imanishi

  Chemistry – An Asian Journal, 15 Aug. 2022

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• Discovery of a Macropinocytosis‐Inducing Peptide Potentiated by Medium‐Mediated Intramolecular Disulfide Formation

  Jan Vincent V. Arafiles; Hisaaki Hirose; Yusuke Hirai; Masashi Kuriyama; Maxwell Mamfe Sakyiamah; Wataru Nomura; Kazuhiro Sonomura; Miki Imanishi; Akira Otaka; Hirokazu Tamamura; Shiroh Futaki

  Angewandte Chemie, 17 May 2021

  
• Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules

  Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Kazuya Murata; Seiya Mizuno; Kenichi Kawano; Miki Imanishi; Fumihiro Sugiyama; Shiroh Futaki

  Angewandte Chemie, 02 Nov. 2020

  
• Functional evaluation of an electrophilic focused library to identify a covalent inhibitor against intrinsically disordered circadian clock transcription factors.

  Kazuya Yamanaka; Yoshihisa Inoue; Miki Imanishi; Junko Ohkanda

  Bioorganic & medicinal chemistry letters, 15 Jan. 2024

  
• Xanthine derivatives inhibit FTO in an L-ascorbic acid-dependent manner.

  Kamui Tanaka; Akiyo Suda; Motonari Uesugi; Shiroh Futaki; Miki Imanishi

  Chemical communications (Cambridge, England), 07 Sep. 2023

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• Effect of charged-cluster distribution of the ZIF268 zinc finger surface on cell membrane permeability

  Shigeru Negi; Mami Hamori; Yuka Kawahara-Nakagawa; Masato Mashimo; Miki Imanishi; Nozomi Kuki; Yuri Kawahito; Takayuki Manabe; Nobuyuki Kawamura; Jyunichiro Yasukawa; Hiroaki Kitagishi; Yukio Sugiura

  Chemistry Letters, 24 Dec. 2022

  
• The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications.

  Shigeru Negi; Miki Imanishi; Mami Hamori; Yuka Kawahara-Nakagawa; Wataru Nomura; Kanae Kishi; Nobuhito Shibata; Yukio Sugiura

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, Apr. 2023

  
• Structural Dissection of Epsin-1 N-Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating Membrane Curvature.

  Motoki Nishimura; Yoshimasa Kawaguchi; Kakeru Kuroki; Yuna Nakagawa; Toshihiro Masuda; Takayuki Sakai; Kenichi Kawano; Hisaaki Hirose; Miki Imanishi; Tomoka Takatani-Nakase; Sergii Afonin; Anne S Ulrich; Shiroh Futaki

  Chemistry (Weinheim an der Bergstrasse, Germany), 06 Mar. 2023

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• Importance of two-dimensional cation clusters induced by protein folding in intrinsic intracellular membrane permeability

  Shigeru Negi; Mami Hamori; Yuka Kawahara-Nakagawa; Miki Imanishi; Miku Kurehara; Chieri Kitada; Yuri Kawahito; Kanae Kishi; Takayuki Manabe; Nobuyuki Kawamura; Hiroaki Kitagishi; Masato Mashimo; Nobuhito Shibata; Yukio Sugiura

  RSC Chemical Biology, 2022

  
• L17ER4: A cell-permeable attenuated cationic amphiphilic lytic peptide

  Kenta Shinga; Takahiro Iwata; Kazuya Murata; Yoko Daitoku; Junya Michibata; Jan Vincent V. Arafiles; Kentarou Sakamoto; Misao Akishiba; Tomoka Takatani-Nakase; Seiya Mizuno; Fumihiro Sugiyama; Miki Imanishi; Shiroh Futaki

  Bioorganic and Medicinal Chemistry, 01 May 2022

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• Split luciferase-based estimation of cytosolic cargo concentration delivered intracellularly via attenuated cationic amphiphilic lytic peptides

  Syusuke Okano; Yoshimasa Kawaguchi; Kenichi Kawano; Hisaaki Hirose; Miki Imanishi; Shiroh Futaki

  Bioorganic and Medicinal Chemistry Letters, Jul. 2022

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• Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells

  Masashi Kuriyama; Hisaaki Hirose; Toshihiro Masuda; Masachika Shudou; Jan Vincent Arafiles; Miki Imanishi; Masashi Maekawa; Yuji Hara; Shiroh Futaki

  Scientific Reports, Dec. 2022

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• Artificial Nanocage Formed via Self-Assembly of β-Annulus Peptide for Delivering Biofunctional Proteins into Cell Interiors.

  Kentarou Sakamoto; Hiroto Furukawa; Jan Vincent V Arafiles; Miki Imanishi; Kazunori Matsuura; Shiroh Futaki

  Bioconjugate chemistry, 16 Feb. 2022

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• Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein-Protein Interactions on a Cell-Penetrating Peptide Scaffold.

  Yuki Nagano; Jan Vincent V Arafiles; Keiko Kuwata; Yoshimasa Kawaguchi; Miki Imanishi; Hisaaki Hirose; Shiroh Futaki

  Molecular pharmaceutics, 07 Feb. 2022

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• Recognition of G-quadruplex RNA by a crucial RNA methyltransferase component, METTL14.

  Atsuhiro Yoshida; Takanori Oyoshi; Akiyo Suda; Shiroh Futaki; Miki Imanishi

  Nucleic acids research, 11 Jan. 2022

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• Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles.

  Yusuke Hirai; Hisaaki Hirose; Miki Imanishi; Tomohiro Asai; Shiroh Futaki

  Scientific reports, 06 Oct. 2021

  
• Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides

  Takahiro Iwata; Hisaaki Hirose; Kentarou Sakamoto; Yusuke Hirai; Jan Vincent V. Arafiles; Misao Akishiba; Miki Imanishi; Shiroh Futaki

  Angewandte Chemie International Edition, 09 Sep. 2021

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• Discovery of a Macropinocytosis-Inducing Peptide Potentiated by Medium-Mediated Intramolecular Disulfide Formation.

  Jan Vincent V Arafiles; Hisaaki Hirose; Yusuke Hirai; Masashi Kuriyama; Maxwell Mamfe Sakyiamah; Wataru Nomura; Kazuhiro Sonomura; Miki Imanishi; Akira Otaka; Hirokazu Tamamura; Shiroh Futaki

  Angewandte Chemie (International ed. in English), 17 May 2021

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• Use of homoarginine to obtain attenuated cationic membrane lytic peptides.

  Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Jan Vincent V Arafiles; Miki Imanishi; Shiroh Futaki

  Bioorganic & medicinal chemistry letters, 15 May 2021

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• Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules.

  Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Kazuya Murata; Seiya Mizuno; Kenichi Kawano; Miki Imanishi; Fumihiro Sugiyama; Shiroh Futaki

  Angewandte Chemie (International ed. in English), 02 Nov. 2020, Peer-reviewed

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• Effective RNA Regulation by Combination of Multiple Programmable RNA-Binding Proteins

  Misaki Sugimoto; Akiyo Suda; Shiroh Futaki; Miki Imanishi

  Applied Sciences, 28 Sep. 2020, Peer-reviewed

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• Identification of synthetic inhibitors for the DNA binding of intrinsically disordered circadian clock transcription factors

  Yusuke Hosoya; Wataru Nojo; Isao Kii; Takanori Suzuki; Miki Imanishi; Junko Ohkanda

  Chemical Communications, Sep. 2020, Peer-reviewed

  
• Enhancing the activity of membrane remodeling epsin-peptide by trimerization.

  Wei-Yuan Hsu; Toshihiro Masuda; Sergii Afonin; Takayuki Sakai; Jan Vincent V Arafiles; Kenichi Kawano; Hisaaki Hirose; Miki Imanishi; Anne S Ulrich; Shiroh Futaki

  Bioorganic & medicinal chemistry letters, 15 Jun. 2020, Peer-reviewed

  
• Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane-Lytic Peptides To Facilitate Endosomal Escape.

  Jan Vincent V Arafiles; Hisaaki Hirose; Misao Akishiba; Shogo Tsuji; Miki Imanishi; Shiroh Futaki

  Bioconjugate chemistry, 18 Mar. 2020, Peer-reviewed

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• Programmable RNA methylation and demethylation using PUF RNA binding proteins.

  Kouki Shinoda; Akiyo Suda; Kenko Otonari; Shiroh Futaki; Miki Imanishi

  Chemical communications (Cambridge, England), 28 Jan. 2020, Peer-reviewed

  
• Conversion of cationic amphiphilic lytic peptides to cell-penetration peptides

  Hao-Hsin Yu; Kentarou Sakamoto; Misao Akishiba; Naoki Tamemoto; Hisaaki Hirose; Ikuhiko Nakase; Miki Imanishi; Fatemeh Madani; Astrid Graslund; Shiroh Futaki

  PEPTIDE SCIENCE, Jan. 2020, Peer-reviewed

  
• Loosening of Lipid Packing by Cell-Surface Recruitment of Amphiphilic Peptides by Coiled-Coil Tethering.

  Takayuki Sakai; Kenichi Kawano; Masatomo Iino; Toshihide Takeuchi; Miki Imanishi; Shiroh Futaki

  Chembiochem : a European journal of chemical biology, 16 Aug. 2019, Peer-reviewed

  
• Modified nucleobase-specific gene regulation using engineered transcription activator-like effectors

  Tsuji S; Imanishi M

  Adv. Drug Deliv. Rev., Jul. 2019, Peer-reviewed, Invited

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• Sequence-specific 5mC detection in live cells based on the TALE-split luciferase complementation system

  Shogo Tsuji; Kouki Shinoda; Shiroh Futaki; Miki Imanishi

  ANALYST, Aug. 2018, Peer-reviewed

  
• Nested PUF Proteins: Extending Target RNA Elements for Gene Regulation

  Kouki Shinoda; Shogo Tsuji; Shiroh Futaki; Miki Imanishi

  ChemBioChem, 18 Jan. 2018, Peer-reviewed

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• Detection of N-6-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease

  Miki Imanishi; Shogo Tsuji; Akiyo Suda; Shiroh Futaki

  CHEMICAL COMMUNICATIONS, Dec. 2017, Peer-reviewed

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• Calmodulin EF-hand peptides as Ca2+-switchable recognition tags

  Akihiko Oku; Miki Imanishi; Daisuke Noshiro; Tomo Murayama; Toshihide Takeuchi; Ikuhiko Nakase; Shiroh Futaki

  BIOPOLYMERS, Jan. 2017, Peer-reviewed

  
• Preparation of Peptide Thioesters From Naturally Occurring Sequences Using Reaction Sequence Consisting of Regioselective S-Cyanylation and Hydrazinolysis

  Rin Miyajima; Yusuke Tsuda; Tsubasa Inokuma; Akira Shigenaga; Miki Imanishi; Shiroh Futaki; Akira Otaka

  BIOPOLYMERS, Jul. 2016, Peer-reviewed

  
• Sequence-specific recognition of methylated DNA by an engineered transcription activator-like effector protein

  Shogo Tsuji; Shiroh Futaki; Miki Imanishi

  CHEMICAL COMMUNICATIONS, 2016, Peer-reviewed

  
• 細胞概日時計の人為的制御

  今西 未来

  化学と生物, 2016, Peer-reviewed

  
• Controlling leucine-zipper partner recognition in cells through modification of a-g interactions

  Yusuke Azuma; Tim Kuekenshoener; Guangyong Ma; Jun-ichiro Yasunaga; Miki Imanishi; Gen Tanaka; Ikuhiko Nakase; Takahiro Maruno; Yuji Kobayashi; Katja M. Arndt; Masao Matsuoka; Shiroh Futaki

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• 体内時計の人工制御：リズム治療への挑戦

  今西 未来

  化学工業（化学工業社）, Jan. 2014, Invited

  
• Creating a TALE protein with unbiased 5 '-T binding

  Shogo Tsuji; Shiroh Futaki; Miki Imanishi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2013, Peer-reviewed

  
• Identification of cellular proteins interacting with octaarginine (R8) cell-penetrating peptide by photo-crosslinking

  Yoshimasa Kawaguchi; Gen Tanaka; Ikuhiko Nakase; Miki Imanishi; Junya Chiba; Yasumaru Hatanaka; Shiroh Futaki

  Bioorganic and Medicinal Chemistry Letters, 01 Jul. 2013, Peer-reviewed

  
• Construction of a Ca2+-gated artificial channel by fusing alamethicin with a calmodulin-derived extramembrane segment

  Daisuke Noshiro; Kazuhiro Sonomura; Hao-Hsin Yu; Miki Imanishi; Koji Asami; Shiroh Futaki

  Bioconjugate Chemistry, 20 Feb. 2013, Peer-reviewed

  
• New functions of zinc fingers revealed by substitution of conserved residues

  Imanishi, M.; Sugiura, Y.

  Zinc Fingers: Structure, Properties, and Applications, 2013, Peer-reviewed

  
• Design of Artificial DNA Binding Proteins toward Control and Elucidation of Cellular Functions

  Miki Imanishi

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2012, Peer-reviewed, Invited

  
• Construction of a Rhythm Transfer System That Mimics the Cellular Clock

  Miki Imanishi; Kazutoshi Yamamoto; Hiroyuki Yamada; Yuka Hirose; Hitoshi Okamura; Shiroh Futaki

  ACS CHEMICAL BIOLOGY, Nov. 2012, Peer-reviewed

  
• Zn(II) Binding and DNA Binding Properties of Ligand-Substituted CXHH-Type Zinc Finger Proteins

  Miki Imanishi; Kazushi Matsumura; Shogo Tsuji; Tomohiro Nakaya; Shigeru Negi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Apr. 2012, Peer-reviewed

  
• Rational design of DNA sequence-specific zinc fingers

  Hidetoshi Kono; Miki Imanishi; Shigeru Negi; Kazuya Tatsutani; Yui Sakaeda; Ayaka Hashimoto; Chie Nakayama; Shiroh Futaki; Yukio Sugiura

  FEBS LETTERS, Mar. 2012, Peer-reviewed

  
• ゲノムを標的とした人工ジンクフィンガータンパク質の創製

  今西未来

  ファルマシア, 01 Mar. 2012, Peer-reviewed

  
• Design of Artificial DNA Binding Proteins toward Control and Elucidation of Cellular Functions (Review)

  Imanishi, M; Sugiura, Y

  Zinc Fingers: Structure, Properties and Applications, , 141-154, 2012, Peer-reviewed

  
• Signal Transduction Using an Artificial Receptor System that Undergoes Dimerization Upon Addition of a Bivalent Leucine-Zipper Ligand

  Ikuhiko Nakase; Shinya Okumura; Gen Tanaka; Katsuhiro Osaki; Miki Imanishi; Shiroh Futaki

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• Dipicolylamine as a unique structural switching element for helical peptides

  Yusuke Azuma; Haruka Imai; Tomoyuki Yoshimura; Takeo Kawabata; Miki Imanishi; Shiroh Futaki

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, Peer-reviewed

  
• Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

  Chung Yeng Looi; Miki Imanishi; Satoshi Takaki; Miki Sato; Natsuko Chiba; Yoji Sasahara; Shiroh Futaki; Shigeru Tsuchiya; Satoru Kumaki

  PLOS ONE, Aug. 2011, Peer-reviewed

  
• An Arginine Residue Instead of a Conserved Leucine Residue in the Recognition Helix of the Finger 3 of Zif268 Stabilizes the Domain Structure and Mediates DNA Binding

  Shigeru Negi; Miki Imanishi; Maeko Sasaki; Kazuya Tatsutani; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Jul. 2011, Peer-reviewed

  
• Control of Circadian Phase by an Artificial Zinc Finger Transcription Regulator

  Miki Imanishi; Atsushi Nakamura; Masao Doi; Shiroh Futaki; Hitoshi Okamura

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• Expressed protein ligation for the preparation of fusion proteins with cell penetrating peptides for endotoxin removal and intracellular delivery

  Hao-Hsin Yu; Ikuhiko Nakase; Silvia Pujals; Hisaaki Hirose; Gen Tanaka; Sayaka Katayama; Miki Imanishi; Shiroh Futaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Dec. 2010, Peer-reviewed

  
• Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp1

  Miki Imanishi; Chika Imamura; Chika Higashi; Wei Yan; Shigeru Negi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2010, Peer-reviewed

  
• Metal-Stimulated Regulation of Transcription by an Artificial Zinc-Finger Protein

  Miki Imanishi; Tomohiro Nakaya; Tatsuya Morisaki; Daisuke Noshiro; Shiroh Futaki; Yukio Sugiura

  CHEMBIOCHEM, Aug. 2010, Peer-reviewed

  
• Artificial Transcription Factors Based on Multi-zinc Finger Motifs

  Tatsuya Morisaki; Miki Imanishi; Shiroh Futaki; Yukio Sugiura

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jan. 2010, Peer-reviewed

  
• Non-FokI-based zinc finger nucleases

  Miki Imanishi; Shigeru Negi; Yukio Sugiura

  Methods in Molecular Biology, 2010, Peer-reviewed

  
• Positive and negative cooperativity of modularly assembled zinc fingers

  Miki Imanishi; Atsushi Nakamura; Tatsuya Morisaki; Shiroh Futaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2009, Peer-reviewed

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• Cobalt(II)-responsive DNA binding of a GCN4-bZIP protein containing cysteine residues functionalized. with iminodiacetic acid

  Yusuke Azuma; Miki Imanishi; Tomoyuki Yoshimura; Takeo Kawabata; Shiroh Futaki

  Angewandte Chemie - International Edition, 01 Sep. 2009, Peer-reviewed

  
• Cytosolic Targeting of Macromolecules Using a pH-Dependent Fusogenic Peptide in Combination with Cationic Liposomes

  Sachiko Kobayashi; Ikuhiko Nakase; Noriko Kawabata; Hao-Hsin Yu; Silvia Pujals; Miki Imanishi; Ernest Giralt; Shiroh Futaki

  BIOCONJUGATE CHEMISTRY, May 2009, Peer-reviewed

  
• Effects of Bulkiness and Hydrophobicity of an Aliphatic Amino Acid in the Recognition Helix of the GAGA Zinc Finger on the Stability of the Hydrophobic Core and DNA Binding Affinity

  Muthu Dhanasekaran; Shigeru Negi; Miki Imanishi; Michiko Suzuki; Yukio Sugiura

  BIOCHEMISTRY, Nov. 2008, Peer-reviewed

  
• Rapid transcriptional activity in vivo and slow DNA binding in vitro by an artificial multi-zinc finger protein

  Tatsuya Morisaki; Miki Imanishi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Sep. 2008, Peer-reviewed

  
• New redesigned zinc-finger proteins: Design strategy and its application

  Shigeru Negi; Miki Imanishi; Makoto Matsumoto; Yukio Sugiura

  CHEMISTRY-A EUROPEAN JOURNAL, 2008, Peer-reviewed

  
• alpha-helical linker of an artificial 6-zinc finger peptide contributes to selective DNA binding to a discontinuous recognition sequence

  Wei Yan; Miki Imanishi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Jul. 2007, Peer-reviewed

  
• DNA-Binding ability of GAGA zinc finger depends on the nature of amino acids present in the beta-hairpin

  Muthu Dhanasekaran; Shigeru Negi; Miki Imanishi; Yukio Sugiura

  BIOCHEMISTRY, Jun. 2007, Peer-reviewed

  
• Artificial zinc finger proteins: desired DNA sequence-specific function toward gene regulation (Review)

  Imanishi, M

  Drug Design Research Perspectives (Nova Science Publishers, Inc.), , 25-37, 2007

  
• Autoinhibition regulates the motility of the C-elegans intraflagellar transport motor OSM-3

  Miki Imanishi; Nicholas F. Endres; Arne Gennerich; Ronald D. Vale

  JOURNAL OF CELL BIOLOGY, Sep. 2006, Peer-reviewed

  
• 遺伝子を標的とした人工亜鉛フィンガータンパク質の創製 (特集/新しいケミカルバイオロジーの研究と展望)

  今西 未来

  化学工業, Sep. 2006

  
• An artificial six-zinc finger peptide with polyarginine linker: Selective binding to the discontinuous DNA sequences

  M Imanishi; W Yan; T Morisaki; Y Sugiura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2005, Peer-reviewed

  
• Effects of linking 15-zinc finger domains on DNA binding specificity and multiple DNA binding modes

  T Hirata; W Nomura; M Imanishi; Y Sugiura

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, May 2005, Peer-reviewed

  
• Site-specific DNA cleavage by artificial zinc finger-type nuclease with cerium-binding peptide

  T Nakatsukasa; Y Shiraishi; S Negi; M Imanishi; S Futaki; Y Sugiura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2005, Peer-reviewed

  
• Swapping of the beta-hairpin region between sp1 and GLI zinc fingers: Significant role of the beta-hairpin region in DNA binding properties of C2H2-type zinc finger peptides

  Y Shiraishi; M Imanishi; T Morisaki; Y Sugiura

  BIOCHEMISTRY, Feb. 2005, Peer-reviewed

  
• Creation and characteristics of unnatural CysHis(3)-type zinc finger protein

  S Negi; M Itazu; M Imanishi; A Nomura; Y Sugiura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2004, Peer-reviewed

  
• Exchange of histidine spacing between Sp1 and GLI zinc fingers: Distinct effect of histidine spacing-linker region on DNA binding

  Y Shiraishi; M Imanishi; Y Sugiura

  BIOCHEMISTRY, May 2004, Peer-reviewed

  
• DNA cleavage characteristics of non-protein enediyne antibiotic N1999A2

  N Miyagawa; D Sasaki; M Matsuoka; M Imanishi; T Ando; Y Sugiura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2003, Peer-reviewed

  
• Artificial DNA-bending six-zinc finger peptides with different charged linkers: Distinct kinetic properties of DNA bindings

  M Imanishi; Y Sugiura

  BIOCHEMISTRY, Jan. 2002, Peer-reviewed

  
• Design of novel zinc finger proteins: towards artificial control of specific gene expression

  M Imanishi; Y Hori; M Nagaoka; Y Sugiura

  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Apr. 2001, Peer-reviewed

  
• Multiconnection of identical zinc finger: Implication for DNA binding affinity and unit modulation of the three zinc finger domain

  M Nagaoka; T Kaji; M Imanishi; Y Hori; W Nomura; Y Sugiura

  BIOCHEMISTRY, Mar. 2001, Peer-reviewed

  
• DNA-bending finger: Artificial design of 6-zinc finger peptides with polyglycine linker and induction of DNA bending

  M Imanishi; Y Hori; M Nagaoka; Y Sugiura

  BIOCHEMISTRY, Apr. 2000, Peer-reviewed

  
• Artificial nine zinc-finger peptide with 30 base pair binding sites

  T Kamiuchi; E Abe; M Imanishi; T Kaji; M Nagaoka; Y Sugiura

  BIOCHEMISTRY, Sep. 1998, Peer-reviewed

  
• 新規亜鉛フィンガータンパク質の創製 (Review)

  今西 未来; 杉浦 幸雄

  化学, 53, 72-73, 1998

  

Misc.

• Screening of G-quadruplex (G4) structure-specific peptide probes

  井田南加; 川口祥正; 二木史朗; 今西未来

  日本薬学会年会要旨集(Web), 2024

  
• Exploration of synthetic agents that inhibit intrinsically disordered circadian clock transcription factors

  細谷侑佑; 能條航; 喜井勲; 鈴木孝紀; 今西未来; 大神田淳子

  日本化学会春季年会講演予稿集(Web), 2021

  
• Artificial Nine Zinc-Finger Peptide with 30-Base Pair Binding Sites (BIOORGANIC CHEMISTRY-Bioactive Chemistry)

  Kamiuchi Tatsuya; Abe Emiko; Imanishi Miki; Kaji Tamaki; Nagaoka Makoto; Sugiura Yukio

  ICR annual report, Mar. 1999

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• DNA結合におけるZIF268亜鉛フィンガードメインのアルギニン残基の重要性

  佐々木麻恵子; 辰谷和弥; 根木滋; 今西未来; 二木史朗; 杉浦幸雄

  日本化学会講演予稿集, 2011

  
• DNA結合におけるGAGA亜鉛フィンガードメイン疎水性コアの重要性の検討

  鈴木美智子; 根木滋; 今西未来; 杉浦幸雄

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 2008

  
• コンピュータによる塩基配列特異的に結合する亜鉛フィンガー型タンパク質の設計とそのキャラクタリゼーション

  河野秀俊; 今西未来; 今西未来; 根木滋; 辰谷和弥; 杉浦幸雄

  日本蛋白質科学会年会プログラム・要旨集, 2008

  
• Modification with Iminodiacetic Acids for Controlling the DNA Binding of GCN4-bZIP Protein by a Metal Ion

  AZUMA Yusuke; IMANISHI Miki; YOSHIMURA Tomoyuki; KAWABATA Takeo; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Properties of modularly assembled zinc finger peptides for creation of engineered transcription regulators

  NAKAMURA Atsushi; IMANISHI Miki; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Time-Dependent Analysis of Artificial Transcription Factors Based on Zinc Finger Peptides

  MORISAKI Tatsuya; IMANISHI Miki; FUTAKI Shiroh; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• Construction of a Calcium-gated Artificial Channel by Fusing Alamethicin with a Calcium Sensor Protein

  NOSHIRO Daisuke; SONOMURA Kazuhiro; YU Hao-Hsin; IMANISHI Miki; ASAMI Koji; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2013

  
• 人工DNA結合蛋白質による細胞分子時計の操作

  今西未来; 中村篤史; 山本和俊; 土居雅夫; 岡村均; 二木史朗

  「細胞を創る」研究会5.0 ,横浜（東京工業大学）, 21 Nov. 2012, Peer-reviewed

  
• Control of Cellular Circadian Phase by an Artificial Zinc-Finger Transcription Factor

  Imanishi, M; Nakamura, A; Doi, M; Okamura, H; Futaki, S

  第39回国際核酸化学シンポジウム ,名古屋, 17 Nov. 2012, Peer-reviewed

  
• 5'-Tthymine recognition by TAL effectors.

  TSUJI, S; Imanishi, M; Futaki, S

  The 39th Inernational Symposium on Nucleic Acids Chemistry ,Toyoda Auditorium, Nagoya University, 16 Nov. 2012, Peer-reviewed

  
• Period1プロモーターを標的とした人工転写因子による細胞時計のリセット

  今西未来; 中村篤史; 土居雅夫; 二木史朗; 岡村均

  第19回日本時間生物学会学術大会 ,札幌（北海道大学）, 15 Sep. 2012, Peer-reviewed

  
• ジンクフィンガーの配位子置換による亜鉛濃度応答性人工転写因子の創製

  今西未来; 辻将吾; 松村一史; 中屋智博; 杉浦幸雄; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会 ,京都（京都大学百周年時計台記念館）, 07 Jun. 2012, Peer-reviewed

  
• 細胞外ドメインの置換によるEGF受容体の会合・活性化制御

  田中弦; 中瀬生彦; 奥村真也; 今西未来; 二木史朗

  第3回統合物質シンポジウム ,福岡（九州大学西新プラザ）, 01 Jun. 2012, Peer-reviewed

  
• Resetting of the cellular circadian clock by an artificial zinc-finger transcription factor

  IMANISHI Miki; NAKAMURA Atsushi; DOI Masao; OKAMURA Hitoshi; FUTAKI Shiroh

  金属の関与する生体関連反応シンポジウム講演要旨集, 21 May 2012, Peer-reviewed

  
• ジピコリルアミン含有ヘリックスペプチドのNi(II)イオン特異的応答性

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  日本薬学会第132回年会 ,札幌（北海道大学）, 29 Mar. 2012, Peer-reviewed

  
• Design and Creation of a Ca2+-sensitive Artificial Channel Protein

  NOSHIRO, Daisuke; SONOMURA, Kazuhiro; Yu H.H; IMANISHI, Miki; ASAMI, Kouji; FUTAKI, Shiroh

  International Symposium on Innovative Nanobiodevices ISIN 2012 ,Nagoya, Japan, 21 Mar. 2012, Peer-reviewed

  
• Circadian Rhythmic Gene Expression Induced by Artificial Clock Proteins

  YAMAMOTO; Kazatoshi; IMANISHI, Miki; HIROSE, Yuka; OKAMURA, Hitoshi; FUTAKI、Shiroh

  The 38th International Symposium on Nucleic Acid Chemistry ,Clark Memorial Student Center, Hokkaido University, 10 Nov. 2011, Peer-reviewed

  
• 人工時計タンパク質を用いた周期的遺伝子発現システムの構築

  山本和俊; 今西未来; 二木史朗

  第５回バイオ関連化学シンポジウム ,つくば（つくば国際会議場「エポカルつくば」）, 13 Sep. 2011, Peer-reviewed

  
• 人工時計タンパク質によるリズミックな遺伝子発現の誘起

  今西未来; 山本和俊; 二木史朗

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 12 Sep. 2011, Peer-reviewed

  
• ジピコリルアミン骨格をもつペプチドによるニッケル(II)の選択的検出

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  第21回金属の関与する生体関連反応シンポジウム ,千葉（千葉大学）, 30 May 2011, Peer-reviewed

  
• 金属イオンによって安定化されるジピコリルアミン骨格含有単鎖へリックス性ペプチドの設計と合成

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  日本ケミカルバイオロジー学会第6回年会 ,東京（東京工業大学）, 25 May 2011, Peer-reviewed

  
• DNA Binding Properties of Ligand-Substituted Zinc Finger Proteins

  IMANISHI Miki; NAKAYA Tomohiro; MATSUMURA Kazushi; FUTAKI Shiroh; SUGIURA Yukio

  金属の関与する生体関連反応シンポジウム講演要旨集, 11 May 2011, Peer-reviewed

  
• Design and Creation of Metal-Responsive DNA-Binding Proteins

  FUTAKI Shiroh; IMANISHI Miki; NAKAYA Tomohiro; MORISAKI Tatsuya; NOSHIRO Daisuke; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Metal-stimulated transcriptional control system using CDH_2-type zinc finger peptides

  NAKAYA Tomohiro; IMANISHI Miki; MORISAKI Tatsuya; NOSHIRO Daisuke; SUGIURA Yukio; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Bidirectional control of the helical structure of a Dpacontaining peptide using divalent metal ions

  Yusuke Azuma; Haruka Imai; Miki Imanishi; Tomoyuki Yoshimura; Takeo Kawabata; Shiroh Futaki

  BIOPOLYMERS, 2011, Peer-reviewed

  
• Creation of a zinc finger type transcription factor responsive to Zn(II) concentration

  中屋智博; 今西未来; 森崎 達也; 能代 大輔; 二木史朗; 杉浦 幸雄

  金属の関与する生体関連反応シンポジウム ,徳島, 25 Jun. 2010, Peer-reviewed

  
• Design and Creation of the GCN4-bZIP Proteins Functionalized with Iminodiacetic Acid for On/Off Switch of the DNA Binding by Metal Ions

  Azuma Y; Imanishi M; Yoshimura T; Kawabata T; Futaki S

  Gordon Research Conference on Bioorganic Chemistry ,Proctor Academy (Andover, NH), 13 Jun. 2010, Peer-reviewed

  
• Functionalization of GCN4-bZIP with iminodiacetic acid that allow the DNA binding to be controlled by a metal ion

  Azuma Y; Imanishi M; Yoshimura T; Kawabata T; Futaki S

  京大／阪大／ソウル大合同シンポジウム ,吹田（大阪大学）, 20 May 2010, Peer-reviewed

  
• ゲノムレベルでの時計遺伝子プロモーター解析を目指した亜鉛フィンガー型人工転写因子の創製とその機能

  中村篤史; 中村篤史; 今西未来; 土居雅夫; 岡村均; 二木史朗

  日本ケミカルバイオロジー学会第5年会 ,横浜（慶応義塾大学日吉キャンパス）, 19 May 2010, Peer-reviewed

  
• 亜鉛濃度に依存した新規転写調節系の開発

  中屋智博; 森崎 達也; 能代 大輔; 今西未来; 二木史朗; 杉浦 幸雄

  日本ケミカルバイオロジー学会 第５回 年会 ,横浜, 18 May 2010, Peer-reviewed

  
• ロイシンジッパー型タンパク質への金属配位子の位置選択的導入とDNA結合スイッチ

  二木史朗; 東佑翼; 今西未来; 吉村智之; 川端猛夫

  第35回反応と合成の進歩シンポジウム ,金沢, 16 Nov. 2009, Peer-reviewed

  
• Expressed Protein Ligation法を用いた膜透過性アルギニンペプチド結合タンパク質の調製と細胞内導入

  游 晧欣; 中瀬 生彦; Silvia Pujals; 今西未来; 二木史朗

  第46回ペプチド討論会 ,北九州, 05 Nov. 2009, Peer-reviewed

  
• 時計遺伝子プロモーター解析へ向けた亜鉛フィンガー型人工転写因子の創製

  中村篤史; 中村篤史; 今西未来; 土居雅夫; 岡村均; 二木史朗

  第6回アジア睡眠学会 日本睡眠学会第34回定期学術集会 第16回日本時間生物学会学術大会. 2009 合同大会 ,大阪, 27 Oct. 2009, Peer-reviewed

  
• 金属錯形成部位のペプチドへの効率的導入法の開発

  東 佑翼; 今西未来; 吉村 智之; 川端 猛夫; 二木史朗

  第24回生体機能関連化学シンポジウム，第12回バイオテクノロジー部会シンポジウム ,福岡, 14 Sep. 2009, Peer-reviewed

  
• Design and creation of a metal-responsive GCN4-bZIP protein modified with iminodiacetic acid (Ida)

  Azuma Y; Imanishi M; Yoshimura T; Kawabata T; Futaki S

  2nd International Symposium on Bioinorganic Chemimstry of the New Era ,Takayama, 02 Aug. 2009, Peer-reviewed

  
• 細胞内におけるマルチ亜鉛フィンガータンパク質のDNA結合特性

  森崎達也; 森崎達也; 今西未来; 二木史朗; 杉浦幸雄

  第9回日本蛋白質科学会年会 ,熊本（熊本全日空ホテルニュースカイ）, 22 May 2009, Peer-reviewed

  
• シスエレメントを標的とした人工ジンクフィンガー連結体のDNA結合性の解析

  今西未来; 今西未来; 中村篤史; 二木史朗

  第9回日本蛋白質科学会年会 ,熊本（熊本全日空ホテルニュースカイ）, 22 May 2009, Peer-reviewed

  
• Metal-induced DNA-binding switch of bZIP proteins modified with iminodiacetic acid (Ida)

  AZUMA Yusuke; IMANISHI Miki; YOSHIMURA Tomoyuki; KAWABATA Takeo; FUTAKI Shiroh

  金属の関与する生体関連反応シンポジウム講演要旨集, 20 May 2009, Peer-reviewed

  
• Creation of Artificial Zinc Finger-Type Transcription Factors and Effects on the Rhythmic Expression of Clock Genes

  IMANISHI Miki; IMANISHI Miki; NAKAMURA Atsushi; FUTAKI Shiroh

  金属の関与する生体関連反応シンポジウム講演要旨集, 20 May 2009, Peer-reviewed

  
• マルチ亜鉛フィンガーのin vitro及びin celluloでの挙動相関

  森崎達也; 今西未来; 二木史朗; 杉浦幸雄

  第3１回日本分子生物学会年会・第8１回日本生化学会大会 合同大会 ,神戸, 09 Dec. 2008, Peer-reviewed

  
• 時計遺伝子プロモーターに作用するジンクフィンガー型人工転写因子の創製

  今西未来; 今西未来; 中村篤史; 二木史朗

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 08 Sep. 2008, Peer-reviewed

  
• マルチ亜鉛フィンガー型人工転写因子による経時的転写活性化能の解析

  森崎達也; 今西未来; 二木史朗; 杉浦幸雄

  第30回日本分子生物学会年会・第80回日本生化学回大会合同大会 ,横浜, 12 Dec. 2007, Peer-reviewed

  
• プロモーターを標的とする人工マルチ亜鉛フィンガータンパク質の創製：モチーフの連結によるDNA結合性への影響

  中村篤史; 今西未来; 二木史朗

  第57回日本薬学会近畿支部大会 ,高槻, 27 Oct. 2007, Peer-reviewed

  
• 遺伝子制御に向けたマルチ亜鉛フィンガータンパク質の創製

  今西未来

  第20回バイオメディカル分析科学シンポジウム ,八王子, 02 Jul. 2007, Peer-reviewed

  
• Linker design of multiple zinc finger peptides: flexible, polycationic, and metal-binding looped linkers

  IMANISHI Miki; YAN Wei; FUTAKI Shiroh; SUGIURA Yukio

  金属の関与する生体関連反応シンポジウム講演要旨集, 01 Jun. 2007, Peer-reviewed

  
• aヘリックスリンカーが人工6-亜鉛フィンガーペプチドのDNA 結合に及ぼす影響

  閻 薇; 今西未来; 二木史朗; 杉浦幸雄

  日本ケミカルバイオロジー研究会 第2回年会 ,京都, 10 May 2007, Peer-reviewed

  
• Creation of artificial zinc finger type transcription factors

  中村篤史; 今西未来; 二木史朗

  日本ケミカルバイオロジー研究会 第2回年会 ,京都, 09 May 2007, Peer-reviewed

  
• Effect of Aromatic Amino Acid, Phenylalanine, Substitution in the β-Hairpin Region of GAGA Zinc Finger on DNA Binding

  DHANASEKARAN Muthu; IMANISHI Miki; NEGI Shigeru; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• New multi zinc finger protein: biosynthetic design and characteristics of DNA recognition.

  Kamiuchi, T.; Imanishi, M.; Abe, E.; Sugiura, Y.

  Nucleic acids symposium series, 1997, Peer-reviewed

  

Presentations

• Development of a simple detection method of RNA modification and its application

  M. Imanishi

  日本薬学会第144年会, 31 Mar. 2024, Invited

  
• 配列・タイミング依存的なRNA修飾操作法の開発

  今西未来

  日本薬学会第144年会, 31 Mar. 2024, Invited

  
• RNA脱メチル化酵素FTOの阻害剤探索及びFTOの補酵素としてのL-アスコルビン酸の役割

  田中 和無爲; 西岡 栞李; 田井 章博; 二木 史朗; 今西 未来

  日本薬学会第144年会, 30 Mar. 2024

  
• RNAメチル化の人為的制御

  今西未来; 田中和無爲; 音成兼光; 上杉志成; 二木史朗

  第40回メディシナルケミストリーシンポジウム, 14 Nov. 2023

  
• Development of higher sequence-selective and timing-controlled m6A demethylation tool

  音成 兼光; 浅見 有璃; 二木 史朗; 今西 未来

  第24回日本RNA学会年会, 07 Jul. 2023

  
• グアニン四重鎖（G4）構造選択的なペプチドプローブのスクリーニング

  井田 南加; 川口 祥正; 二木 史朗; 今西 未来

  日本薬学会第144年会, 29 Mar. 2023

  
• 核酸構造の多元機能とエピトランスクリプトームとの 接点を知る

  今西未来

  第13回CSJ化学フェスタ2023, 17 Oct. 2023, Invited

  
• Detection and Sequence-Specific Control of RNA Modifications

  Miki Imanishi; Kenko Otonari; Koki Shinoda; Shiroh Futaki

  The 19th Akabori Conference, 18 May 2023, Invited

  
• オフターゲットを低減した 配列選択的RNA脱メチル化酵素の創製

  今西未来; 音成兼光; 浅見有璃; 二木史朗

  日本薬学会第143年会, 27 Mar. 2023

  
• カスタム遺伝子制御：ゲノム編集のこれから

  今西未来

  日本薬学会関西支部市民公開講座, 04 Dec. 2022, Invited

  
• グアニン四重鎖RNAのエピトランスクリプトーム制御への関与

  今西未来

  第95回日本生化学会大会, 10 Nov. 2022, Invited

  
• RNAメチル化の検出と配列特異的制御

  今西未来

  弘前大学大学院理工学研究科 生物有機化学特論, 02 Nov. 2022, Invited

  
• グアニン四重鎖構造を介したRNAアデノシンメチル化

  今西未来; 吉田敦裕; 大吉崇文; 二木史朗

  第16回バイオ関連化学シンポジウム, 11 Sep. 2022

  
• Specific binding of RNA methyltransferase-related protein, METTL14, to RNA G-quadruplex

  今西未来; 吉田敦裕; 大吉崇文; 二木史朗

  日本薬学会第142年会, 27 Mar. 2022

  
• Targeted RNA Methylation and Demethylation Using Artificial RNA Binding Proteins

  Miki Imanishi

  Pacifichem 2021, 21 Dec. 2021, Invited

  
• エピトランスクリプトームを制御する人工タンパク質の創製

  今西未来

  第21回日本蛋白質科学会年会, 18 Jun. 2021, Invited

  
• 核酸メチル化修飾の検出と操作

  今西未来

  大阪市立大学大学院工学研究科BMEC第 9 回 セミナー, 07 Jun. 2021, Invited

  
• Targeted RNA methylation and demethylation using artificial RNA binding proteins

  Miki Imanishi

  MBSJ2020, 02 Dec. 2020, Invited

  
• エピトランスクリプトームを制御するテーラーメイドタンパク質

  今西未来

  第93回日本生化学会大会, 14 Sep. 2020, Invited

  
• 配列選択的RNA結合タンパク質を用いたRNAメチル化状態の配列特異的制御

  今西 未来; 篠田 昂樹; 須田 明代; 二木 史朗

  第14回バイオ関連化学シンポジウム, 08 Sep. 2020

  
• Engineering 16-repeats PUF proteins to sequence-specifically manipulate RNA functions

  Imanishi, M; Shinoda, K; Futaki, S

  ICSB2019, 02 Nov. 2019

  
• A simple screening system for inhibitors of m6A-regulatory enzymes

  Imanishi, M; Suda, A; Futaki, S

  10th Joint RSC-CSJ Symposium: Chemistry for Complex Biological System, 07 Sep. 2019

  
• N6-メチルアデノシン調節酵素活性の簡便な検出法の開発

  今西 未来; 須田 明代; 二木 史朗

  第13回バイオ関連化学シンポジウム, 04 Sep. 2019

  
• RNAを標的とした遺伝子発現操作

  今西 未来

  第２２回生命化学研究会, 21 Jun. 2019, Invited

  
• Artificial DNA/RNA binding proteins regulating specific gene expression

  IMANISHI Miki

  5th Asian Chemical Biology Conference, 20 Aug. 2018, Invited

  
• Design of nucleic acid binding proteins to control cellular events

  IMANISHI Miki

  Kumamoto Univ. HIGO program seminar, 11 Jul. 2018, Invited

  
• Detection of the m6A-regulatory-enzymes activities using an endoribonuclease, MazF

  Miki Imanishi; Akiyo Suda; Shiroh Futaki

  RNA 2018, The 23rd Annual Meeting of the RNA Society, 31 May 2018

  
• エンドリボヌクレアーゼMazFを用いたN6-メチルアデノシン調節酵素活性の検出法の開発

  今西未来; 須田明代; 二木史朗

  第65回日本生化学会近畿支部例会, 26 May 2018

  
• 遺伝子発現を制御する人工タンパク質の創製と概日リズム研究への応用

  今西 未来

  第二回名古屋リズム研究会, 22 Mar. 2018, Invited

  
• 遺伝子発現を制御する人工タンパク質の創

  今西 未来

  日本化学会第98春季年会, 20 Mar. 2018, Invited

  
• Engineering of nested PUF proteins with 16 RNA-binding repeats for regulation of endogenous RNA

  Kouki Shinoda; Miki Imanishi; Shiroh Futaki

  ISBC2017 The International Symposium on Biofunctional Chemistry, 15 Dec. 2017

  
• Development of a simple strategy to detect activities of N6-methyladenosine regulatory enzymes

  Miki Imanishi; Akiyo Suda; Shiroh Futaki

  ISBC2017 The International Symposium on Biofunctional Chemistry, 15 Dec. 2017

  
• RNA結合タンパク質PUFの認識塩基数拡張と内在RNAの制御

  篠田 昂樹; 今西 未来; 二木 史朗

  ConBio2017生命科学系合同年次大会, 06 Dec. 2017

  
• Engineering of nucleic acid binding proteins toward manipulation of gene expression

  IMANISHI Miki

  日中若手女性研究者会議, 04 Nov. 2017, Invited

  
• 配列選択的RNA結合蛋白質PUFの結合領域の拡張と遺伝子発現制御

  今西 未来; 篠田 昂樹; 辻 将吾; 二木 史朗

  第11回バイオ関連化学シンポジウム, 07 Sep. 2017

  
• Extending RNA sequence recognition of PUF proteins toward RNA sequence-specific regulation

  Kouki Shinoda; Miki Imanishi; Shiroh Futaki

  RNA2017 The 22nd Annual Meeting of the RNA Society, 31 May 2017

  
• Enzymatic detection of activities of m6A RNA methyltransferases and demetylases

  Miki Imanishi; Akiyo Suda; Shiroh Futaki

  RNA2017 The 22nd Annual Meeting of the RNA Society, Apr. 2017

  
• メチル化シトシン選択性を有する ゲノム編集ツールの創製

  今西 未来

  日本薬学会第137年会, 25 Mar. 2017, Invited

  
• 天然にないDNA認識能を持つTALEタンパク質の開発

  今西 未来

  第89回日本生化学会大会, 25 Sep. 2016, Invited

  
• Design of artificial DNA binding proteins towards manipulation of cellular functions

  IMANISHI Miki

  The 53rd Annual Meeting of the Biophysical Society of Japan, 13 Sep. 2015, Invited

  
• Design of artificial DNA binding proteins towards manipulation of biological rhythms

  IMANISHI Miki

  Awaji-Yumebutai Symposium on RNA & CLOCK 2015, 26 Mar. 2015, Invited

  
• 遺伝子発現リズムを操る人工タンパク質の創製

  今西 未来

  「細胞を創る」研究会7.0, 14 Nov. 2014, Invited

  
• Control of the circadian clock by artificial transcription factors

  IMANISHI Miki

  3rd Switzerland-Japan Biomolecular Chemistry Symposium, 03 Oct. 2014, Invited

  
• Manipulation of the cellular clock using artificial transcription factors

  IMANISHI Miki

  FASEB SRC "Genome engineering:Cutting-edge research and application", 24 Jun. 2014, Invited

  
• 5’末端塩基非依存的Transcriptional Activator-like Protein (TALE) の創出

  今西 未来; 辻将吾; 二木史朗

  日本ケミカルバイオロジー学会 第９回年会, 11 May 2014

  
• Control of circadian rhythms by artificial transcription factors

  IMANISHI Miki

  Molecular Clock 2014, 29 Mar. 2014, Invited

  
• 人工タンパク質による概日振動発現の誘起

  今西 未来; 山本和俊; 二木史朗

  日本薬学会第134年会, 28 Mar. 2014

  
• One-hybrid screeningを用いたTALEタンパク質の標的塩基変換

  今西 未来; 辻将吾; 二木史朗

  第16回生命化学研究会, 09 Jan. 2014

  
• 人工転写因子による概日リズムの操作

  今西未来; 中村篤史; 土居雅夫; 二木史朗; 岡村均

  第36回日本分子生物学会年会, 03 Dec. 2013

  
• 分子進化法を用いたTALE蛋白質の標的DNA条件の解除

  今西未来; 辻将吾; 二木史朗

  細胞を創る研究会6.0, 14 Nov. 2013

  
• Molecular evolution of a TALE protein to change DNA binding manner

  今西 未来

  CBI学会2013年大会 -生命医薬情報学連合大会-, 29 Oct. 2013, Invited

  
• Control of cellular circadian clock by artificial transcription factors

  今西未来; 中村篤史; 山本和俊; 岡村均; 二木史朗

  国際ケミカルバイオロジー学会（ICBS）第２回年会（ICBS2013), 08 Oct. 2013

  
• 人工DNA結合タンパク質による概日リズムの操作

  今西未来; 中村篤史; 山本和俊; 土居雅夫; 岡村 均; 二木史朗

  第7回バイオ関連化学シンポジウム, 27 Sep. 2013

  
• 人工転写因子を用いた細胞分子時計の操作

  今西 未来

  日本薬学会第133年会, 29 Mar. 2013, Invited

  
• 人工DNA結合蛋白質による細胞分子時計の操作

  今西未来; 中村篤史; 山本和俊; 土居雅夫; 岡村均; 二木史朗

  「細胞を創る」研究会5.0, 21 Nov. 2012

  
• Control of Cellular Circadian Phase by an Artificial Zinc-finger Transcription Factor

  Imanishi, M; Nakamura, A; Doi, M; Okamura, H; Futaki, S

  第39回国際核酸化学シンポジウム, 17 Nov. 2012

  
• 5'-Tthymine Recognition by TAL Effectors.

  Tsuji, S; Imanishi, M; Futaki, S

  The 39th Inernational Symposium on Nucleic Acids Chemistry, 16 Nov. 2012

  
• ジンクフィンガーモチーフを用いた人工転写因子の創製と応用

  ナノバイオ研究会, 14 Nov. 2012, 名古屋

  
• New Functions of Zinc Fingers Revealed by Substitution of Conserved Residues

  第５０回日本生物物理学会年会, 22 Sep. 2012, 名古屋

  
• Period1プロモーターを標的とした人工転写因子による細胞時計のリセット

  今西未来; 中村篤史; 土居雅夫; 二木史朗; 岡村均

  第19回日本時間生物学会学術大会 ,札幌, 15 Sep. 2012

  
• ジンクフィンガーの配位子置換による亜鉛濃度応答性人工転写因子の創製

  今西未来; 辻将吾; 松村一史; 中屋智博; 杉浦幸雄; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会, 17 Jun. 2012

  
• 細胞外ドメインの置換によるEGF受容体の会合・活性化制御

  田中弦; 中瀬生彦; 奥村真也; 今西未来; 二木史朗

  第3回統合物質シンポジウム, 01 Jun. 2012

  
• Design and Creation of a Ca2+-sensitive Artificial Channel Protein

  Noshiro, D; Sonomura, K; Yu, H.H; Imanishi, M; Asami, K; Futaki, S

  International Symposium on Innovative Nanobiodevices ISIN 2012, 31 Mar. 2012

  
• 人工DNA結合タンパク質のデザインと細胞機能制御への展開

  日本薬学会第132年会, 30 Mar. 2012, 札幌

  
• ジンクフィンガー型人工転写因子の創製と細胞機能の制御

  日本薬学会第132年会, 29 Mar. 2012, 札幌

  
• ジピコリルアミン含有ヘリックスペプチドのNi(II)イオン特異的応答性

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  日本薬学会第132回年会, 29 Mar. 2012

  
• 人工時計タンパク質によるサーカディアン型遺伝子発現リズムの誘起

  今西未来; 山本和俊; 岡村均; 二木史朗

  第１４回生命化学研究会, 02 Dec. 2011

  
• Circadian Rhythmic Gene Expression Induced by Artificial Clock Protein

  YAMAMOTO, K; IMANISHI, M; HIROSE, Y; OKAMURA, H; FUTAKI, S

  The 38th International Symposium on Nucleic Acid Chemistry, 10 Nov. 2011

  
• 人工時計タンパク質を用いた周期的遺伝子発現システムの構築

  山本和俊; 今西 未来; 二木 史朗

  第61回日本薬学会近畿支部大会, 22 Oct. 2011

  
• 人工時計タンパク質によるリズミックな遺伝子発現の誘起

  今西未来; 山本和俊; 二木史朗

  第５回バイオ関連化学シンポジウム ,つくば, 14 Sep. 2011

  
• 人工時計タンパク質を用いた周期的遺伝子発現システムの構築

  山本和俊; 今西 未来; 二木 史朗

  第５回バイオ関連化学シンポジウム, 13 Sep. 2011

  
• Bidirectional control of the helical structure of a Dpa-containing peptide using divalent metal ions

  AZUMA, Y; IMAI, H; IMANISHI, M; YOSHIMURA, T; KAWABATA, T; FUTAKI, S

  22nd American Peptide Symposium, 25 Jun. 2011

  
• ジピコリルアミン骨格をもつペプチドによるニッケル(II)の選択的検出

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  第21回金属の関与する生体関連反応シンポジウム, 30 May 2011

  
• DNA Binding Properties of Ligand-Substituted Zinc Finger Proteins

  今西未来; 中屋智博; 松村一史; 二木史朗; 杉浦幸雄

  第21回金属の関与する生体関連反応シンポジウム, 30 May 2011

  
• 金属イオンによって安定化されるジピコリルアミン骨格含有単鎖へリックス性ペプチドの設計と合成

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  日本ケミカルバイオロジー学会第6回年会, 25 May 2011

  
• ジンクフィンガー型人工転写因子を用いた細胞時計の制御

  今西未来; 中村篤史; 土居雅夫; 二木史朗; 岡村均

  日本ケミカルバイオロジー学会第6回年会 ,東京, 25 May 2011

  
• ジンクフィンガーモチーフを用いた新規DNA結合タンパク質の創製

  日本薬学会第131年会, 30 Mar. 2011, 静岡

  
• Creation of Artificial DNA Binding Proteins Based on Properties of a C2H2 Zinc Finger Motif

  日本農芸化学会2011年度大会, 28 Mar. 2011, 京都

  
• 亜鉛フィンガー型人工転写因子を用いた細胞時計制御

  第17回日本時間生物学会学術大会, 20 Nov. 2010, 東京都

  
• 生命現象の制御を目指した人工転写因子の創製

  日本薬学会第130年会, 29 Mar. 2010, 岡山市

  
• ジンクフィンガー型人工タンパク質の創製と機能

  奈良先端科学技術大学院大学物質創成科学研究科 光ナノサイエンス特別講義, 10 Feb. 2010, 生駒市

  
• 生命現象解明ツールとしてのジンクフィンガー型人工転写因子の創製

  第１２回生命化学研究会（2010）, 09 Jan. 2010, あわら市

  
• Creation of Artificial Zinc Finger-Based Transcription Factors

  Department seminar, School of Pharmacy, University of Maryland, 21 Sep. 2009, Baltimore, USA

  
• 遺伝子制御に向けたマルチ亜鉛フィンガータンパク質の創製

  第20回バイオメディカル分析科学シンポジウム, 02 Jul. 2007, 八王子

  
• 亜鉛フィンガー型人工転写因子の創製：遺伝子制御と情報解析に向けて

  今西未来

  日本薬学会第127年会 ,富山, 29 Mar. 2007

  
• 亜鉛フィンガーを用いた人工DNA結合タンパク質の創製とその応用

  日本分析化学会第55年会, 22 Sep. 2006, 豊中

  
• Artificial 6-zinc finger peptides with various linkers

  Metalloprotein and Protein Design Conference, 30 Jul. 2005, Chicago, USA

  

Awards

• 16 Apr. 2013

  文部科学大臣, 平成２５年度　文部科学大臣表彰　若手科学者賞
• 28 Mar. 2012

  日本薬学会, 平成24年度日本薬学会奨励賞
• 09 Dec. 2011

  京都大学化学研究所, 第16回京大化研奨励賞
• 24 Sep. 2008

  Royal Society of Chemistry, The Best Poster Award

External funds: Kakenhi

• Development of a sequence and stimulation dependent regulation method of epitranscriptome and its application to biological clock

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  Miki Imanishi

  From 09 Jul. 2021, To 31 Mar. 2023, Project Closed

  RNAメチル化;RNA結合タンパク質;RNA脱メチル化;酵素再構成系;N6-メチルアデノシン;エピトランスクリプトーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19046/
• Biological function of non-canonical nucleic acids

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (II)

  Kyoto University

  今西 未来

  From 23 Aug. 2021, To 31 Mar. 2024, Granted

  RNAメチル化;非標準核酸構造;核酸高次構造;遺伝子制御;RNAメチル化修飾

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05110/
• Control of RNA modification aimed at antivirus activities

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37030:Chemical biology-related

  Kyoto University

  Miki Imanishi

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  RNAメチル化;脱メチル化酵素;非標準核酸構造;エピトランスクリプトーム;RNA脱メチル化;FTO;RNA高次構造;RNAメチル化制御;RNA修飾

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H02850/
• Exploration of synthetic molecules that control intrinsically disordered proteins

  Grant-in-Aid for Challenging Exploratory Research

  Shinshu University

  Junko Ohkanda

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  非構造性たんぱく質;概日時計転写因子;IDPs;阻害剤探索;Bmal1;Clock;蛍光偏光結合試験;組換えたんぱく質発現;E-Box DNA;蛍光サーマルシフト;蛍光偏光;概日リズム;転写因子;中分子ライブラリ;非構造たんぱく質;阻害剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K13098/
• Sequence specific detection and manipulation of epigenetic status

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Miki Imanishi

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  核酸結合タンパク質;核酸修飾;メチル化シトシン;TALE;TALEタンパク質;エピゲノム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H03281/
• 細胞時計同調の包括的理解と人為的制御のための人工入力系の構築

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  今西 未来

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  DNA結合タンパク質;概日時計

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26119709/
• Elucidation of DNA binding modes of TALEs and creation of artificial DNA binding proteins

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Miki IMANISHI

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  DNA binding protein;Directed evolution;DNA結合タンパク質;TALE;転写因子;DNA結合蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24510295/
• 細胞時計を模倣した周期的遺伝子発現システムの構築

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  今西 未来

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  遺伝子発現;概日時計;人工転写因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24119507/
• Creation of artificial clock proteins to induce rhythmic gene expression

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Miki IMANISHI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  遺伝子発現;ジンクフィンガー;人工転写因子;タンパク質デザイン;概日時計

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22710213/
• DNA結合タンパク質の揺らぎによる配列特異的DNA結合への影響

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  今西 未来

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  ジンクフィンガー;DNA結合;構造安定性;揺らぎ

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21107513/
• Creation of artificial transcription factors for artificial gene circuits

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Miki IMANISHI

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  亜鉛フィンガー;人工転写因子;遺伝子制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20710165/
• 亜鉛フィンガータンパク質間相互作用に基づく新規転写促進分子の創製

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  今西 未来

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  DNA結合ドメイン;亜鉛フィンガータンパク質;タンパク質間相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18710183/
• Development of intracellular targeting peptide vectors and the real-time observation in cells.

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Shiroh FUTAKI

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  アルギニンペプチド;細胞内送達;ペプチドベクター;エンドサイトーシス;核;ミトコンドリア, arginine-rich peptide;intracellular delivery;peptide vector;endocytosis;nucleus;mitochondria

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390029/
• Creation of New Functional Artificial Metallofingers : Construction of Library and Development to Gene Regulation

  Grant-in-Aid for Scientific Research (B)

  Doshisha Women's College of Liberal Arts

  Yukio SUGIURA

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  金属フィンガー;亜鉛フィンガー;DNA認識;タンパク質デザイン;マルチフィンガー;ライブラリー;GAGA因子;遺伝子制御;タンパク質設計;転写因子;GAGAファクター;人工設計, Metallofinger;Zinc Finger;DNA Recognition;Protein Design;Multifinger;Library;GAGA Factor;Gene Regulation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390028/
• 世界最長のマルチ亜鉛フィンガーの創製と新機能

  Grant-in-Aid for Exploratory Research

  Doshisha Women's College of Liberal Arts;Kyoto University

  杉浦 幸雄

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  亜鉛フィンガー;マルチフィンガー;DNA結合;塩基配列特異性;リンカー配列;遺伝子機能;タンパク質設計;モチーフ;長鎖認識

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16659028/
• Site-specific and high efficient epitranscriptomic manipulation based on the enzymatic activity

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related

  Kyoto University

  今西 未来

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  RNAメチル化修飾酵素;エピトランスクリプトーム;ゲノム編集;RNA脱メチル化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02210/
• Elucidation of the mechanism for dimensional response genome

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (II)

  Konan University

  建石 寿枝

  From 23 Aug. 2021, To 31 Mar. 2024, Granted

  核酸非二重らせん構造;生物種;遺伝子発現;多元応答ゲノムバンク;多元応答機構;多元応答ゲノム機構;細胞内環境;多元応答ゲノムバンク（DiR-GB）;定量的解析

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-21H05107/
• Site-specific and high efficient epitranscriptomic manipulation based on the enzymatic activity

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related

  Kyoto University

  今西 未来

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  RNA脱メチル化;N6メチルアデノシン;RNAメチル化修飾酵素;エピトランスクリプトーム;ゲノム編集

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K23477/
• ビタミンCの新しい機能に基づく新規エピゲノム調節剤の開発

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  今西 未来

  From 28 Jun. 2024, To 31 Mar. 2026, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21825/
• Development of epigenomic modulators based on the function of Vitamin C

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  今西 未来

  From 28 Jun. 2024, To 31 Mar. 2026, Granted

  RNA脱メチル化;N6-methyladenosine;ビタミンC

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21825/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Biofunctional Chemistry

  4210, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Biological Chemistry IV (Applied biomolecular science)

  C215, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biological Chemistry 4 (Applied biomolecular science)

  A215, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Biofunctional Chemistry

  3210, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Biofunctional Chemistry Seminar

  2310, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Biofunctional Chemistry

  4210, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Biofunctional Chemistry

  3210, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Biological Chemistry IV (Applied biomolecular science)

  C215, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biological Chemistry 4 (Applied biomolecular science)

  A215, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Biofunctional Chemistry Seminar

  2310, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Biological Chemistry IV (Applied biomolecular science)

  C215, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Biofunctional Chemistry

  4210, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Biological Chemistry 4 (Applied biomolecular science)

  A215, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Biofunctional Chemistry Seminar

  2310, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Biofunctional Chemistry

  3210, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Biological Chemistry 4 (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Biological Chemistry 4 (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Biological Chemistry 4 (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Biological Chemistry IV (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Biological Chemistry 4 (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Biological Chemistry IV (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Biological Chemistry 4 (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Biological Chemistry IV (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Biological Chemistry 4 (Applied biomolecular science)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目

Administration

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  化学研究所総務・教務委員会委員
• From 01 Jan. 2023, To 31 Mar. 2024

  化学研究所男女共同参画推進委員会
• From 01 Apr. 2022, To 31 Mar. 2023

  化学研究所広報委員会委員
• From 01 Apr. 2013, To 31 Mar. 2014

  化学研究所広報委員会 委員
• From 01 Apr. 2013, To 31 Mar. 2014

  化学研究所情報システム技術委員会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  化学研究所総務・教務委員会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  化学研究所講演委員会委員