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Yasuhara, Takaaki
Graduate School of Biostudies, Division of Systemic Life Science Professor
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Last Updated :2025/05/30
Basic Information
Email Address
Email Address
yasuhara.takaaki.7r
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Undergraduate School/Majors)
Research History
- From Jul. 2023, To PresentKyoto University, Graduate School of Biostudies, Professor
- From Apr. 2023, To Jun. 2023The University of Tokyo, Isotope Science Center, Project Lecturer
- From Oct. 2021, To Mar. 2023The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assistant Professor
- From Jun. 2018, To Oct. 2021Massachusetts General Hospital, Cancer Center, Research Fellow
- From Jun. 2018, To May 2020Japan Society for the Promotion of Science, JSPS Overseas Research Fellow
- From Apr. 2015, To Jun. 2018The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assitant Professor
- From Apr. 2012, To Mar. 2015Japan Society for the Promotion of Science, Research Fellow (DC1)
ID,URL
ORCID ID
J-Global ID
Researcher number
90757056External link
researchmap URL
list
Last Updated :2025/05/30
Research
Research Interests
Research Areas
- Life sciences, Genomics
- Life sciences, Tumor biology
- Life sciences, Radiology
- Environmental science/Agricultural science, Environmental effects of radiation
Papers
- Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaksKie Ozaki; Reona Kato; Takaaki Yasuhara; Yuki Uchihara; Miyako Hirakawa; Yu Abe; Hiroki Shibata; Reika Kawabata-Iwakawa; Aizhan Shakayeva; Palina Kot; Kiyoshi Miyagawa; Keiji Suzuki; Naoki Matsuda; Atsushi Shibata; Motohiro YamauchiScientific Reports, 08 Aug. 2024, Peer-reviewed
- Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent mannerPeter W. T. Lee; Tatsuya Suwa; Minoru Kobayashi; Hui Yang; Lina R. Koseki; Satoshi Takeuchi; Christalle C. T. Chow; Takaaki Yasuhara; Hiroshi HaradaBritish Journal of Cancer, 13 May 2024, Peer-reviewed
- An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stressTaichi Igarashi; Marianne Mazevet; Takaaki Yasuhara; Kimiyoshi Yano; Akifumi Mochizuki; Makoto Nishino; Tatsuya Yoshida; Yukihiro Yoshida; Nobuhiko Takamatsu; Akihide Yoshimi; Kouya Shiraishi; Hidehito Horinouchi; Takashi Kohno; Ryuji Hamamoto; Jun Adachi; Lee Zou; Bunsyo ShiotaniNature Communications, Aug. 2023, Peer-reviewed
- DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production.Yuki Uchihara; Tiara Bunga Mayang Permata; Hiro Sato; Reika Kawabata-Iwakawa; Sayako Katada; Wenchao Gu; Sangeeta Kakoti; Motohiro Yamauchi; Reona Kato; Soehartati Gondhowiardjo; Naoki Hosen; Takaaki Yasuhara; Atsushi ShibataMolecular Cell, 13 May 2022, Peer-reviewed
- Mechanism of chromosome rearrangement arising from single-strand breaksPalina Kot; Takaaki Yasuhara; Atsushi Shibata; Miyako Hirakawa; Yu Abe; Motohiro Yamauchi; Naoki MatsudaBiochemical and Biophysical Research Communications, Oct. 2021, Peer-reviewed
- Impacts of chromatin dynamics and compartmentalization on DNA repair.Takaaki Yasuhara; Lee ZouDNA Repair, Sep. 2021, Peer-reviewed, Invited, Lead author
- High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells.Tiara Bunga Mayang Permata; Hiro Sato; Wenchao Gu; Sangeeta Kakoti; Yuki Uchihara; Yukihiko Yoshimatsu; Itaru Sato; Reona Kato; Motohiro Yamauchi; Keiji Suzuki; Takahiro Oike; Yoshito Tsushima; Soehartati Gondhowiardjo; Tatsuya Ohno; Takaaki Yasuhara; Atsushi ShibataJournal of radiation research, 01 Jul. 2021, Peer-reviewed
- CARM1 regulates replication fork speed and stress response by stimulating PARP1Marie-Michelle Genois; Jean-Philippe Gagné; Takaaki Yasuhara; Jessica Jackson; Sneha Saxena; Marie-France Langelier; Ivan Ahel; Mark T. Bedford; John M. Pascal; Alessandro Vindigni; Guy G. Poirier; Lee ZouMolecular Cell, Feb. 2021, Peer-reviewed
- RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cellsNakako Izumi Nakajima; Motohiro Yamauchi; Sangeeta Kakoti; Liu Cuihua; Reona Kato; Tiara Bunga Mayang Permata; Moito Iijima; Hirohiko Yajima; Takaaki Yasuhara; Shigeru Yamada; Sumitaka Hasegawa; Atsushi ShibataDNA Repair, Jul. 2020, Peer-reviewed
- DNA Repair and Signaling in Immune-Related Cancer Therapy.Sangeeta Kakoti; Hiro Sato; Siddhartha Laskar; Takaaki Yasuhara; Atsushi ShibataFrontiers in molecular biosciences, 2020, Peer-reviewed
- Base excision repair regulates PD-L1 expression in cancer cells.Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Hiro Sato; Takaaki Yasuhara; Takahiro Oike; Soehartati Gondhowiardjo; Kathryn D Held; Takashi Nakano; Atsushi ShibataOncogene, Jun. 2019, Peer-reviewed
- Regulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicineHiro Sato; Penny A. Jeggo; Atsushi Shibata; Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi ShibataCancer Science, 2019, Peer-reviewed
- p53 deficiency augments nucleolus instability after ionizing irradiation.Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi Shibata; Corresponding authorOncology Reports, 2019, Peer-reviewed
- Elucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.Atsushi Shibata; Takaaki YasuharaImpact, 2019, Invited
- The role of R-loops in transcription-associated DNA double-strand break repairReona Kato; Kiyoshi Miyagawa; Takaaki YasuharaMolecular Cellular Oncology, Jan. 2019, Peer-reviewed, Invited, Last author, Corresponding author
- Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination RepairTakaaki Yasuhara; Reona Kato; Yoshihiko Hagiwara; Bunsyo Shiotani; Motohiro Yamauchi; Shinichiro Nakada; Atsushi Shibata; Kiyoshi MiyagawaCell, Oct. 2018, Peer-reviewed, Lead author, Corresponding author
- 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.Yoshihiko Hagiwara; Atsuko Niimi; Mayu Isono; Motohiro Yamauchi; Takaaki Yasuhara; Siripan Limsirichaikul; Takahiro Oike; Hiro Sato; Kathryn D Held; Takashi Nakano; Atsushi ShibataOncotarget, 12 Dec. 2017, Peer-reviewed
- DNA double-strand break repair pathway regulates PD-L1 expression in cancer cellsHiro Sato; Atsuko Niimi; Takaaki Yasuhara; Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Mayu Isono; Endang Nuryadi; Ryota Sekine; Takahiro Oike; Sangeeta Kakoti; Yuya Yoshimoto; Kathryn D. Held; Yoshiyuki Suzuki; Koji Kono; Kiyoshi Miyagawa; Takashi Nakano; Atsushi ShibataNature Communications, Nov. 2017, Peer-reviewed
- High RAD54B expression: An independent predictor of postoperative distant recurrence in colorectal cancer patientsYuzo Nagai; Yoko Yamamoto; Takaaki Yasuhara; Keisuke Hata; Takeshi Nishikawa; Toshiaki Tanaka; Junichiro Tanaka; Tomomichi Kiyomatsu; Kazushige Kawai; Hiroaki Nozawa; Shinsuke Kazama; Hironori Yamaguchi; Soichiro Ishihara; Eiji Sunami; Takeharu Yamanaka; Kiyoshi Miyagawa; Toshiaki WatanabeOncotarget, 2015, Peer-reviewed
Presentations
- Aging and chromosome translocations in germline cellsTakaaki YasuharaHIGO最先端研究セミナー, 13 Nov. 2024, Invited
- ゲノム安定性を司る核酸協調のメカニズム安原 崇哲核酸医薬学会第9回年会 シンポジウム, 16 Jul. 2024, Invited
- ジョブハンティングを振り返って ～ いまできる準備をしよう！ ～安原 崇哲第３回 生命科学系３研究科合同セミナー 〜めざせ！近未来のPI〜, 01 Mar. 2024, Invited
- Toward an understanding of how chromosome translocations occurTakaaki YasuharaRadiation Biology Center Mini-symposium, 23 Oct. 2023, Invited
- Genome maintenance by transcription-associated DNA double-strand break repairTakaaki Yasuhara2nd Fukuoka RNA commons, 20 Oct. 2023, Invited
- RNAを介したゲノム安定性維持機構安原崇哲RNAフロンティアミーティング2023, 19 Oct. 2023, Invited
- How Our Genome Is Protected From MutagenesisAsian Young Scientist Fellowship Annual Conference 2023, 16 Oct. 2023, Invited
- Condensates induced by nucleolar stresses mediate gene fusionTakaaki Yasuhara19th Ataxia-Telangiectasia workshop（ATW2023）, 04 Mar. 2023
- Genome maintenance by RNA-mediated stress responsesTakaaki Yasuhara11th International Symposium Gunma University Initiative for Advanced Research, 01 Mar. 2022, Invited
- 凝集体を介したがんゲノム異常発生メカニズム安原崇哲第44回日本分子生物学会年会, Dec. 2021, Invited
- RNA転写とDNA二重鎖切断修復のクロストーク安原崇哲第42回日本分子生物学会年会, Dec. 2019, Invited
- 細胞周期依存的な転写共役型DNA二重鎖切断修復の制御機構安原崇哲日本放射線影響学会第60回大会, Oct. 2017, Invited
- 細胞機能間ネットワークを標的とした新たながん治療戦略安原崇哲第４回 群大Genome Damage Discussion Group公開セミナー, May 2016, Invited
Books and Other Publications
- RNA を介したゲノム安定性の維持機構安原崇哲月刊「アグリバイオ」 2022年 6巻 77-81, Nov. 2022
- ゲノム安定性維持機構におけるarcRNA の役割安原崇哲ニューサイエンス社 月刊「細胞」, Jul. 2022
- Elucidation of the Mechanism Regulating Transcription Associated Dna Double Strand Break Repair and Its PathwayAtsushi Shibata; Takaaki YasuharaImpact 2019 50-51 2019, 2019
Awards
- 04 Dec. 2015若手優秀発表賞(日本分子生物学会・日本生化学会)
- 29 May 2015Young Investigators Award(International Congress of Radiation Research 2015)
- 17 Oct. 2015優秀論文賞(若手放射線生物学研究会)
- 07 Apr. 2023令和5年度科学技術分野の文部科学大臣表彰 若手科学者賞
- 04 May 20232023 Fellow(Asian Young Scientist Fellowship)
External funds: Kakenhi
- Genome instability induced by spatial positions in the nucleusGrant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)Kyoto University安原 崇哲From 01 Apr. 2023, To 31 Mar. 2025, Grantedゲノム脆弱部位;核内位置空間;マッピング法
- A strategy to transform genomic organization and change the gene expression pattern via controlling nucleolar condensatesGrant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)Kyoto University;The University of Tokyo安原 崇哲From 16 Jun. 2022, To 31 Mar. 2024, Project Closed核小体;凝集体;ゲノム構造変換;遺伝子発現誘導;RNA結合タンパク質;液―液相分離
- Investigation of the new factors regulating transcription-associated DNA double-strand break repairGrant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedThe University of Tokyo安原 崇哲From 01 Apr. 2021, To 31 Mar. 2026, Granted染色体転座;DNA修復;転写;がんゲノム異常;DSB修復;R-loop;ゲノム安定性;RAP80
- 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究Grant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedKeio University;Gunma University柴田 淳史From 01 Apr. 2021, To 31 Mar. 2025, GrantedDSB修復;放射線;NHEJ;HR;DNA修復;クロマチン;転写;染色体転座
- The mechanism for gene fusion mediated by condensatesFund for the Promotion of Joint International Research (Fostering Joint International Research (A))Basic Section 63020:Radiation influence-relatedKyoto University;The University of TokyoTakaaki YasuharaFrom 01 Apr. 2020, To 31 Mar. 2024, Project Closed凝集体;ゲノム異常;染色体転座;転写;がんゲノム異常
- Elucidation of transcription-coupled chromosomal translocation pathways between gene lociGrant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 50:Oncology and related fieldsGunma UniversityAtsushi ShibataFrom 30 Jul. 2020, To 31 Mar. 2023, Project ClosedDNA二本鎖切断;放射線;染色体転座;DNA切断;発がん;転写共役型DNA修復
- Elucidation of the mechanism underlying DNA replication stress response regulating genomic instabilityFund for the Promotion of Joint International Research (Fostering Joint International Research (B))Medium-sized Section 50:Oncology and related fieldsNational Cancer Center JapanBunsyo ShiotaniFrom 07 Feb. 2019, To 31 Mar. 2023, Project ClosedDNA複製ストレス;ゲノム不安定性;RNA転写;ヘテロクロマチン;ATR;PrimPol;KRAS;肺がん;発がん
- The roles of R-loop structure in DNA damage signaling and genomeGrant-in-Aid for Early-Career ScientistsBasic Section 63020:Radiation influence-relatedThe University of TokyoTakaaki YasuharaFrom 01 Apr. 2018, To 31 Mar. 2022, DiscontinuedR-loop構造;DNA二重鎖切断;DNA損傷シグナリング;DNA修復
- Mechanism for cancer-related upregulation of the Rad54B-mediated cellular function networkGrant-in-Aid for Research Activity Start-upThe University of TokyoTakaaki YASUHARAFrom 28 Aug. 2015, To 31 Mar. 2017, Project Closedがん;細胞機能ネットワーク;Rad54B;細胞周期;E2Fファミリー
- Investigation of the new factors regulating transcription- associated DNA double-strand break repairGrant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedKyoto University;The University of Tokyo安原 崇哲From 01 Apr. 2021, To 31 Mar. 2026, Granted染色体転座;がんゲノム異常;DNA修復;転写;DSB修復;R-loop;ゲノム安定性;RAP80
- 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究Grant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedKeio University;Gunma University柴田 淳史From 01 Apr. 2021, To 31 Mar. 2025, GrantedDNA修復;放射線;NHEJ;HR;クロマチン;染色体転座;DSB修復;転写
- 相置換による転写－修復カップリング変容がもたらす染色体異常の解明Grant-in-Aid for Scientific Research (A)Medium-sized Section 44:Biology at cellular to organismal levels, and related fieldsKyoto University安原 崇哲From 01 Apr. 2025, To 31 Mar. 2030, Adopted
list
Last Updated :2025/05/30
Education
Teaching subject(s)
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar D2009, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar C2008, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar C2008, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar D2009, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar A2006, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar B2007, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar B2007, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Experimental Course and Seminar A2006, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2025, To 31 Mar. 2026Cancer Biology1022, Fall, Graduate School of Biostudies, 2
- From 01 Apr. 2024, To 31 Mar. 2025Introduction to Biology and Life ScienceN484, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Course in Chromosome Researches1027, Spring, Graduate School of Biostudies, 1
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Experiments in Systemic Life Sciences5013, Fall, Graduate School of Biostudies, 4
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Experiments in Systemic Life Sciences5013, Spring, Graduate School of Biostudies, 4
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar B2007, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar B2007, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar A2006, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar D2009, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar C2008, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar C2008, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar A2006, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar D2009, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Cancer Biology1022, Fall, Graduate School of Biostudies, 2
Participation in PhD Defense
- 患者由来膵管腺がんオルガノイドにおける細胞内シグナル活性の定量的ライブイメージングとシグナル伝達経路を標的とした阻害剤の薬効評価TSUKAMOTO SHOKO, Graduate School of Biostudies, Sub-chief Examiner24 Mar. 2025
- 染色体融合レポーターを用いた微小核誘導後のcGAS/STING経路応答の解析SATO YUKI, Graduate School of Biostudies, Sub-chief Examiner23 May 2024
- 小型細胞外小胞への新規RNA移行シグナルの同定岡 祐馬, Graduate School of Biostudies, Sub-chief Examiner23 Jul. 2024
- Hes1による発現動態依存的な細胞増殖制御機構の解明MAEDA YUKI, Graduate School of Biostudies, Sub-chief Examiner24 Nov. 2023
