Basic Information

Email Address

• Email Address

  yasuhara.takaaki.7rkyoto-u.ac.jp

Professional Memberships

• THE JAPANESE RADIATION RESEARCH SOCIETY
• THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Academic Degree

• 24 Mar. 2015

  東京大学博士（医学）

Academic Resume (Undergraduate School/Majors)

• 東京大学, 医学部医学科（PhD-MDコース）, 退学

Research History

• From Jul. 2023, To Present

  Kyoto University, Graduate School of Biostudies, Professor
• From Apr. 2023, To Jun. 2023

  The University of Tokyo, Isotope Science Center, Project Lecturer
• From Oct. 2021, To Mar. 2023

  The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assistant Professor
• From Jun. 2018, To Oct. 2021

  Massachusetts General Hospital, Cancer Center, Research Fellow
• From Jun. 2018, To May 2020

  Japan Society for the Promotion of Science, JSPS Overseas Research Fellow
• From Apr. 2015, To Jun. 2018

  The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assitant Professor
• From Apr. 2012, To Mar. 2015

  Japan Society for the Promotion of Science, Research Fellow (DC1)

ID,URL

• ORCID ID

  0000-0002-6719-5709

• J-Global ID

  201801020143201243

• Researcher number

  90757056

• External link

  https://www.rbc.kyoto-u.ac.jp/genome_stress/en/

researchmap URL

• https://researchmap.jp/tyasuhara

Research

Research Interests

• DNA damage response
• DNA repair
• Genome stability
• Transcription
• Condensate
• Senescence

Research Areas

• Life sciences, Genomics
• Life sciences, Tumor biology
• Life sciences, Radiology
• Environmental science/Agricultural science, Environmental effects of radiation

Papers

• An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress

  Taichi Igarashi; Marianne Mazevet; Takaaki Yasuhara; Kimiyoshi Yano; Akifumi Mochizuki; Makoto Nishino; Tatsuya Yoshida; Yukihiro Yoshida; Nobuhiko Takamatsu; Akihide Yoshimi; Kouya Shiraishi; Hidehito Horinouchi; Takashi Kohno; Ryuji Hamamoto; Jun Adachi; Lee Zou; Bunsyo Shiotani

  Nature Communications, Aug. 2023, Peer-reviewed

  
• Condensates induced by transcription inhibition localize active chromatin to nucleoli

  Takaaki Yasuhara; Yu-Hang Xing; Nicholas C. Bauer; Lukuo Lee; Rui Dong; Tribhuwan Yadav; Roy J. Soberman; Miguel N. Rivera; Lee Zou

  Molecular Cell, Jun. 2022, Peer-reviewed, Lead author

  
• DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production.

  Yuki Uchihara; Tiara Bunga Mayang Permata; Hiro Sato; Reika Kawabata-Iwakawa; Sayako Katada; Wenchao Gu; Sangeeta Kakoti; Motohiro Yamauchi; Reona Kato; Soehartati Gondhowiardjo; Naoki Hosen; Takaaki Yasuhara; Atsushi Shibata

  Molecular Cell, 13 May 2022, Peer-reviewed

  
• 

  RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair

  Takaaki Yasuhara; Reona Kato; Motohiro Yamauchi; Yuki Uchihara; Lee Zou; Kiyoshi Miyagawa; Atsushi Shibata

  Cell Reports, Feb. 2022, Peer-reviewed, Lead author, Corresponding author

  
• Mechanism of chromosome rearrangement arising from single-strand breaks

  Palina Kot; Takaaki Yasuhara; Atsushi Shibata; Miyako Hirakawa; Yu Abe; Motohiro Yamauchi; Naoki Matsuda

  Biochemical and Biophysical Research Communications, Oct. 2021, Peer-reviewed

  
• Impacts of chromatin dynamics and compartmentalization on DNA repair.

  Takaaki Yasuhara; Lee Zou

  DNA Repair, Sep. 2021, Peer-reviewed, Invited, Lead author

  
• High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells.

  Tiara Bunga Mayang Permata; Hiro Sato; Wenchao Gu; Sangeeta Kakoti; Yuki Uchihara; Yukihiko Yoshimatsu; Itaru Sato; Reona Kato; Motohiro Yamauchi; Keiji Suzuki; Takahiro Oike; Yoshito Tsushima; Soehartati Gondhowiardjo; Tatsuya Ohno; Takaaki Yasuhara; Atsushi Shibata

  Journal of radiation research, 01 Jul. 2021, Peer-reviewed

  
• CARM1 regulates replication fork speed and stress response by stimulating PARP1

  Marie-Michelle Genois; Jean-Philippe Gagné; Takaaki Yasuhara; Jessica Jackson; Sneha Saxena; Marie-France Langelier; Ivan Ahel; Mark T. Bedford; John M. Pascal; Alessandro Vindigni; Guy G. Poirier; Lee Zou

  Molecular Cell, Feb. 2021, Peer-reviewed

  
• RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells

  Nakako Izumi Nakajima; Motohiro Yamauchi; Sangeeta Kakoti; Liu Cuihua; Reona Kato; Tiara Bunga Mayang Permata; Moito Iijima; Hirohiko Yajima; Takaaki Yasuhara; Shigeru Yamada; Sumitaka Hasegawa; Atsushi Shibata

  DNA Repair, Jul. 2020, Peer-reviewed

  
• DNA Repair and Signaling in Immune-Related Cancer Therapy.

  Sangeeta Kakoti; Hiro Sato; Siddhartha Laskar; Takaaki Yasuhara; Atsushi Shibata

  Frontiers in molecular biosciences, 2020, Peer-reviewed

  
• Base excision repair regulates PD-L1 expression in cancer cells.

  Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Hiro Sato; Takaaki Yasuhara; Takahiro Oike; Soehartati Gondhowiardjo; Kathryn D Held; Takashi Nakano; Atsushi Shibata

  Oncogene, Jun. 2019, Peer-reviewed

  
• Regulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicine

  Hiro Sato; Penny A. Jeggo; Atsushi Shibata; Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi Shibata

  Cancer Science, 2019, Peer-reviewed

  
• p53 deficiency augments nucleolus instability after ionizing irradiation.

  Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi Shibata; Corresponding author

  Oncology Reports, 2019, Peer-reviewed

  
• Elucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.

  Atsushi Shibata; Takaaki Yasuhara

  Impact, 2019, Invited

  
• The role of R-loops in transcription-associated DNA double-strand break repair

  Reona Kato; Kiyoshi Miyagawa; Takaaki Yasuhara

  Molecular Cellular Oncology, Jan. 2019, Peer-reviewed, Invited, Last author, Corresponding author

  
• 

  Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

  Takaaki Yasuhara; Reona Kato; Yoshihiko Hagiwara; Bunsyo Shiotani; Motohiro Yamauchi; Shinichiro Nakada; Atsushi Shibata; Kiyoshi Miyagawa

  Cell, Oct. 2018, Peer-reviewed, Lead author, Corresponding author

  
• 

  3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.

  Yoshihiko Hagiwara; Atsuko Niimi; Mayu Isono; Motohiro Yamauchi; Takaaki Yasuhara; Siripan Limsirichaikul; Takahiro Oike; Hiro Sato; Kathryn D Held; Takashi Nakano; Atsushi Shibata

  Oncotarget, 12 Dec. 2017, Peer-reviewed

  
• 

  DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells

  Hiro Sato; Atsuko Niimi; Takaaki Yasuhara; Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Mayu Isono; Endang Nuryadi; Ryota Sekine; Takahiro Oike; Sangeeta Kakoti; Yuya Yoshimoto; Kathryn D. Held; Yoshiyuki Suzuki; Koji Kono; Kiyoshi Miyagawa; Takashi Nakano; Atsushi Shibata

  Nature Communications, Nov. 2017, Peer-reviewed

  
• 

  High RAD54B expression: An independent predictor of postoperative distant recurrence in colorectal cancer patients

  Yuzo Nagai; Yoko Yamamoto; Takaaki Yasuhara; Keisuke Hata; Takeshi Nishikawa; Toshiaki Tanaka; Junichiro Tanaka; Tomomichi Kiyomatsu; Kazushige Kawai; Hiroaki Nozawa; Shinsuke Kazama; Hironori Yamaguchi; Soichiro Ishihara; Eiji Sunami; Takeharu Yamanaka; Kiyoshi Miyagawa; Toshiaki Watanabe

  Oncotarget, 2015, Peer-reviewed

  
• 

  Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength

  Takaaki Yasuhara; Takahiko Suzuki; Mari Katsura; Kiyoshi Miyagawa

  Nature Communications, Nov. 2014, Peer-reviewed, Lead author

  

Awards

• 04 Dec. 2015

  若手優秀発表賞(日本分子生物学会・日本生化学会)
• 29 May 2015

  Young Investigators Award(International Congress of Radiation Research 2015)
• 17 Oct. 2015

  優秀論文賞(若手放射線生物学研究会)
• 07 Apr. 2023

  令和5年度科学技術分野の文部科学大臣表彰　若手科学者賞
• 04 May 2023

  2023 Fellow(Asian Young Scientist Fellowship)

External funds: Kakenhi

• Genome instability induced by spatial positions in the nucleus

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  The University of Tokyo

  安原 崇哲

  From 01 Apr. 2023, To 31 Mar. 2025, Granted

  ゲノム脆弱部位;核内位置空間;マッピング法

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23H04274/
• A strategy to transform genomic organization and change the gene expression pattern via controlling nucleolar condensates

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  The University of Tokyo

  安原 崇哲

  From 16 Jun. 2022, To 31 Mar. 2024, Granted

  核小体;凝集体;ゲノム構造変換;遺伝子発現誘導

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H05585/
• Investigation of the new factors regulating transcription-associated DNA double-strand break repair

  Grant-in-Aid for Scientific Research (B)

  Basic Section 63020:Radiation influence-related

  The University of Tokyo

  安原 崇哲

  From 01 Apr. 2021, To 31 Mar. 2026, Granted

  染色体転座;DNA修復;転写;がんゲノム異常;DSB修復;R-loop;ゲノム安定性;RAP80

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03597/
• 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究

  Grant-in-Aid for Scientific Research (B)

  Basic Section 63020:Radiation influence-related

  Keio University;Gunma University

  柴田 淳史

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  DSB修復;放射線;NHEJ;HR;DNA修復;クロマチン;転写;染色体転座

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03596/
• 凝集体を介した染色体転座発生メカニズムの解明

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))

  Basic Section 63020:Radiation influence-related

  The University of Tokyo

  安原 崇哲

  From 01 Apr. 2020, To 31 Mar. 2023, Granted

  染色体転座;凝集体;転写;がんゲノム異常

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20KK0339/
• 遺伝子領域間に引き起こされる転写共役型染色体転座経路の解明

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 50:Oncology and related fields

  Gunma University

  柴田 淳史

  From 30 Jul. 2020, To 31 Mar. 2023, Granted

  DNA切断;染色体転座;発がん;DNA二本鎖切断;転写共役型DNA修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21536/
• Elucidation of the mechanism underlying DNA replication stress response regulating genomic instability

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 50:Oncology and related fields

  National Cancer Center Japan

  塩谷 文章

  From 07 Feb. 2019, To 31 Mar. 2022, Granted

  DNA複製ストレス;ATR;ゲノム不安定性;発がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0235/
• The roles of R-loop structure in DNA damage signaling and genome

  Grant-in-Aid for Early-Career Scientists

  Basic Section 63020:Radiation influence-related

  The University of Tokyo

  Takaaki Yasuhara

  From 01 Apr. 2018, To 31 Mar. 2022, Discontinued

  R-loop構造;DNA二重鎖切断;DNA損傷シグナリング;DNA修復

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K18191/
• Mechanism for cancer-related upregulation of the Rad54B-mediated cellular function network

  Grant-in-Aid for Research Activity Start-up

  The University of Tokyo

  Takaaki YASUHARA

  From 28 Aug. 2015, To 31 Mar. 2017, Project Closed

  がん;細胞機能ネットワーク;Rad54B;細胞周期;E2Fファミリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H06146/