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Yasuhara, Takaaki

Graduate School of Biostudies, Division of Systemic Life Science Professor

Yasuhara, Takaaki
list
    Last Updated :2025/02/12

    Basic Information

    Email Address

    • Email Address

      yasuhara.takaaki.7rkyoto-u.ac.jp

    Professional Memberships

    • THE JAPANESE RADIATION RESEARCH SOCIETY
    • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

    Academic Degree

    • 24 Mar. 2015
      東京大学博士(医学)

    Academic Resume (Undergraduate School/Majors)

    • 東京大学, 医学部医学科(PhD-MDコース), 退学

    Research History

    • From Jul. 2023, To Present
      Kyoto University, Graduate School of Biostudies, Professor
    • From Apr. 2023, To Jun. 2023
      The University of Tokyo, Isotope Science Center, Project Lecturer
    • From Oct. 2021, To Mar. 2023
      The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assistant Professor
    • From Jun. 2018, To Oct. 2021
      Massachusetts General Hospital, Cancer Center, Research Fellow
    • From Jun. 2018, To May 2020
      Japan Society for the Promotion of Science, JSPS Overseas Research Fellow
    • From Apr. 2015, To Jun. 2018
      The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assitant Professor
    • From Apr. 2012, To Mar. 2015
      Japan Society for the Promotion of Science, Research Fellow (DC1)

    ID,URL

    researchmap URL

    list
      Last Updated :2025/02/12

      Research

      Research Interests

      • DNA damage response
      • DNA repair
      • Genome stability
      • Transcription
      • Condensate
      • Senescence

      Research Areas

      • Life sciences, Genomics
      • Life sciences, Tumor biology
      • Life sciences, Radiology
      • Environmental science/Agricultural science, Environmental effects of radiation

      Papers

      • Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks
        Kie Ozaki; Reona Kato; Takaaki Yasuhara; Yuki Uchihara; Miyako Hirakawa; Yu Abe; Hiroki Shibata; Reika Kawabata-Iwakawa; Aizhan Shakayeva; Palina Kot; Kiyoshi Miyagawa; Keiji Suzuki; Naoki Matsuda; Atsushi Shibata; Motohiro Yamauchi
        Scientific Reports, 08 Aug. 2024, Peer-reviewed
      • Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner
        Peter W. T. Lee; Tatsuya Suwa; Minoru Kobayashi; Hui Yang; Lina R. Koseki; Satoshi Takeuchi; Christalle C. T. Chow; Takaaki Yasuhara; Hiroshi Harada
        British Journal of Cancer, 13 May 2024, Peer-reviewed
      • An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress
        Taichi Igarashi; Marianne Mazevet; Takaaki Yasuhara; Kimiyoshi Yano; Akifumi Mochizuki; Makoto Nishino; Tatsuya Yoshida; Yukihiro Yoshida; Nobuhiko Takamatsu; Akihide Yoshimi; Kouya Shiraishi; Hidehito Horinouchi; Takashi Kohno; Ryuji Hamamoto; Jun Adachi; Lee Zou; Bunsyo Shiotani
        Nature Communications, Aug. 2023, Peer-reviewed
      • Condensates induced by transcription inhibition localize active chromatin to nucleoli
        Takaaki Yasuhara; Yu-Hang Xing; Nicholas C. Bauer; Lukuo Lee; Rui Dong; Tribhuwan Yadav; Roy J. Soberman; Miguel N. Rivera; Lee Zou
        Molecular Cell, Jun. 2022, Peer-reviewed, Lead author
      • DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production.
        Yuki Uchihara; Tiara Bunga Mayang Permata; Hiro Sato; Reika Kawabata-Iwakawa; Sayako Katada; Wenchao Gu; Sangeeta Kakoti; Motohiro Yamauchi; Reona Kato; Soehartati Gondhowiardjo; Naoki Hosen; Takaaki Yasuhara; Atsushi Shibata
        Molecular Cell, 13 May 2022, Peer-reviewed
      • RAP80 suppresses the vulnerability of R-loops during DNA double-strand break repair
        Takaaki Yasuhara; Reona Kato; Motohiro Yamauchi; Yuki Uchihara; Lee Zou; Kiyoshi Miyagawa; Atsushi Shibata
        Cell Reports, Feb. 2022, Peer-reviewed, Lead author, Corresponding author
      • Mechanism of chromosome rearrangement arising from single-strand breaks
        Palina Kot; Takaaki Yasuhara; Atsushi Shibata; Miyako Hirakawa; Yu Abe; Motohiro Yamauchi; Naoki Matsuda
        Biochemical and Biophysical Research Communications, Oct. 2021, Peer-reviewed
      • Impacts of chromatin dynamics and compartmentalization on DNA repair.
        Takaaki Yasuhara; Lee Zou
        DNA Repair, Sep. 2021, Peer-reviewed, Invited, Lead author
      • High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells.
        Tiara Bunga Mayang Permata; Hiro Sato; Wenchao Gu; Sangeeta Kakoti; Yuki Uchihara; Yukihiko Yoshimatsu; Itaru Sato; Reona Kato; Motohiro Yamauchi; Keiji Suzuki; Takahiro Oike; Yoshito Tsushima; Soehartati Gondhowiardjo; Tatsuya Ohno; Takaaki Yasuhara; Atsushi Shibata
        Journal of radiation research, 01 Jul. 2021, Peer-reviewed
      • CARM1 regulates replication fork speed and stress response by stimulating PARP1
        Marie-Michelle Genois; Jean-Philippe Gagné; Takaaki Yasuhara; Jessica Jackson; Sneha Saxena; Marie-France Langelier; Ivan Ahel; Mark T. Bedford; John M. Pascal; Alessandro Vindigni; Guy G. Poirier; Lee Zou
        Molecular Cell, Feb. 2021, Peer-reviewed
      • RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells
        Nakako Izumi Nakajima; Motohiro Yamauchi; Sangeeta Kakoti; Liu Cuihua; Reona Kato; Tiara Bunga Mayang Permata; Moito Iijima; Hirohiko Yajima; Takaaki Yasuhara; Shigeru Yamada; Sumitaka Hasegawa; Atsushi Shibata
        DNA Repair, Jul. 2020, Peer-reviewed
      • DNA Repair and Signaling in Immune-Related Cancer Therapy.
        Sangeeta Kakoti; Hiro Sato; Siddhartha Laskar; Takaaki Yasuhara; Atsushi Shibata
        Frontiers in molecular biosciences, 2020, Peer-reviewed
      • Base excision repair regulates PD-L1 expression in cancer cells.
        Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Hiro Sato; Takaaki Yasuhara; Takahiro Oike; Soehartati Gondhowiardjo; Kathryn D Held; Takashi Nakano; Atsushi Shibata
        Oncogene, Jun. 2019, Peer-reviewed
      • Regulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicine
        Hiro Sato; Penny A. Jeggo; Atsushi Shibata; Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi Shibata
        Cancer Science, 2019, Peer-reviewed
      • p53 deficiency augments nucleolus instability after ionizing irradiation.
        Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi Shibata; Corresponding author
        Oncology Reports, 2019, Peer-reviewed
      • Elucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.
        Atsushi Shibata; Takaaki Yasuhara
        Impact, 2019, Invited
      • The role of R-loops in transcription-associated DNA double-strand break repair
        Reona Kato; Kiyoshi Miyagawa; Takaaki Yasuhara
        Molecular Cellular Oncology, Jan. 2019, Peer-reviewed, Invited, Last author, Corresponding author
      • Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair
        Takaaki Yasuhara; Reona Kato; Yoshihiko Hagiwara; Bunsyo Shiotani; Motohiro Yamauchi; Shinichiro Nakada; Atsushi Shibata; Kiyoshi Miyagawa
        Cell, Oct. 2018, Peer-reviewed, Lead author, Corresponding author
      • 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.
        Yoshihiko Hagiwara; Atsuko Niimi; Mayu Isono; Motohiro Yamauchi; Takaaki Yasuhara; Siripan Limsirichaikul; Takahiro Oike; Hiro Sato; Kathryn D Held; Takashi Nakano; Atsushi Shibata
        Oncotarget, 12 Dec. 2017, Peer-reviewed
      • DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
        Hiro Sato; Atsuko Niimi; Takaaki Yasuhara; Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Mayu Isono; Endang Nuryadi; Ryota Sekine; Takahiro Oike; Sangeeta Kakoti; Yuya Yoshimoto; Kathryn D. Held; Yoshiyuki Suzuki; Koji Kono; Kiyoshi Miyagawa; Takashi Nakano; Atsushi Shibata
        Nature Communications, Nov. 2017, Peer-reviewed
      • High RAD54B expression: An independent predictor of postoperative distant recurrence in colorectal cancer patients
        Yuzo Nagai; Yoko Yamamoto; Takaaki Yasuhara; Keisuke Hata; Takeshi Nishikawa; Toshiaki Tanaka; Junichiro Tanaka; Tomomichi Kiyomatsu; Kazushige Kawai; Hiroaki Nozawa; Shinsuke Kazama; Hironori Yamaguchi; Soichiro Ishihara; Eiji Sunami; Takeharu Yamanaka; Kiyoshi Miyagawa; Toshiaki Watanabe
        Oncotarget, 2015, Peer-reviewed
      • Rad54B serves as a scaffold in the DNA damage response that limits checkpoint strength
        Takaaki Yasuhara; Takahiko Suzuki; Mari Katsura; Kiyoshi Miyagawa
        Nature Communications, Nov. 2014, Peer-reviewed, Lead author

      Presentations

      • Aging and chromosome translocations in germline cells
        Takaaki Yasuhara
        HIGO最先端研究セミナー, 13 Nov. 2024, Invited
      • ゲノム安定性を司る核酸協調のメカニズム
        安原 崇哲
        核酸医薬学会第9回年会 シンポジウム, 16 Jul. 2024, Invited
      • ジョブハンティングを振り返って ~ いまできる準備をしよう! ~
        安原 崇哲
        第3回 生命科学系3研究科合同セミナー 〜めざせ!近未来のPI〜, 01 Mar. 2024, Invited
      • Toward an understanding of how chromosome translocations occur
        Takaaki Yasuhara
        Radiation Biology Center Mini-symposium, 23 Oct. 2023, Invited
      • Genome maintenance by transcription-associated DNA double-strand break repair
        Takaaki Yasuhara
        2nd Fukuoka RNA commons, 20 Oct. 2023, Invited
      • RNAを介したゲノム安定性維持機構
        安原崇哲
        RNAフロンティアミーティング2023, 19 Oct. 2023, Invited
      • How Our Genome Is Protected From Mutagenesis
        Asian Young Scientist Fellowship Annual Conference 2023, 16 Oct. 2023, Invited
      • Condensates induced by nucleolar stresses mediate gene fusion
        Takaaki Yasuhara
        19th Ataxia-Telangiectasia workshop(ATW2023), 04 Mar. 2023
      • Genome maintenance by RNA-mediated stress responses
        Takaaki Yasuhara
        11th International Symposium Gunma University Initiative for Advanced Research, 01 Mar. 2022, Invited
      • 凝集体を介したがんゲノム異常発生メカニズム
        安原崇哲
        第44回日本分子生物学会年会, Dec. 2021, Invited
      • RNA転写とDNA二重鎖切断修復のクロストーク
        安原崇哲
        第42回日本分子生物学会年会, Dec. 2019, Invited
      • 細胞周期依存的な転写共役型DNA二重鎖切断修復の制御機構
        安原崇哲
        日本放射線影響学会第60回大会, Oct. 2017, Invited
      • 細胞機能間ネットワークを標的とした新たながん治療戦略
        安原崇哲
        第4回 群大Genome Damage Discussion Group公開セミナー, May 2016, Invited

      Books and Other Publications

      • RNA を介したゲノム安定性の維持機構
        安原崇哲
        月刊「アグリバイオ」 2022年 6巻 77-81, Nov. 2022
      • ゲノム安定性維持機構におけるarcRNA の役割
        安原崇哲
        ニューサイエンス社 月刊「細胞」, Jul. 2022
      • Elucidation of the Mechanism Regulating Transcription Associated Dna Double Strand Break Repair and Its Pathway
        Atsushi Shibata; Takaaki Yasuhara
        Impact 2019 50-51 2019, 2019

      Awards

      • 04 Dec. 2015
        若手優秀発表賞(日本分子生物学会・日本生化学会)
      • 29 May 2015
        Young Investigators Award(International Congress of Radiation Research 2015)
      • 17 Oct. 2015
        優秀論文賞(若手放射線生物学研究会)
      • 07 Apr. 2023
        令和5年度科学技術分野の文部科学大臣表彰 若手科学者賞
      • 04 May 2023
        2023 Fellow(Asian Young Scientist Fellowship)

      External funds: Kakenhi

      • Genome instability induced by spatial positions in the nucleus
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Kyoto University;The University of Tokyo
        安原 崇哲
        From 01 Apr. 2023, To 31 Mar. 2025, Granted
        ゲノム脆弱部位;核内位置空間;マッピング法
      • A strategy to transform genomic organization and change the gene expression pattern via controlling nucleolar condensates
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        The University of Tokyo
        安原 崇哲
        From 16 Jun. 2022, To 31 Mar. 2024, Granted
        核小体;凝集体;ゲノム構造変換;遺伝子発現誘導;RNA結合タンパク質;液―液相分離
      • Investigation of the new factors regulating transcription-associated DNA double-strand break repair
        Grant-in-Aid for Scientific Research (B)
        Basic Section 63020:Radiation influence-related
        The University of Tokyo
        安原 崇哲
        From 01 Apr. 2021, To 31 Mar. 2026, Granted
        染色体転座;DNA修復;転写;がんゲノム異常;DSB修復;R-loop;ゲノム安定性;RAP80
      • 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究
        Grant-in-Aid for Scientific Research (B)
        Basic Section 63020:Radiation influence-related
        Keio University;Gunma University
        柴田 淳史
        From 01 Apr. 2021, To 31 Mar. 2025, Granted
        DSB修復;放射線;NHEJ;HR;DNA修復;クロマチン;転写;染色体転座
      • 凝集体を介した染色体転座発生メカニズムの解明
        Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))
        Basic Section 63020:Radiation influence-related
        The University of Tokyo
        安原 崇哲
        From 01 Apr. 2020, To 31 Mar. 2024, Granted
        染色体転座;凝集体;転写;がんゲノム異常
      • Elucidation of transcription-coupled chromosomal translocation pathways between gene loci
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 50:Oncology and related fields
        Gunma University
        Atsushi Shibata
        From 30 Jul. 2020, To 31 Mar. 2023, Project Closed
        DNA二本鎖切断;放射線;染色体転座;DNA切断;発がん;転写共役型DNA修復
      • Elucidation of the mechanism underlying DNA replication stress response regulating genomic instability
        Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
        Medium-sized Section 50:Oncology and related fields
        National Cancer Center Japan
        Bunsyo Shiotani
        From 07 Feb. 2019, To 31 Mar. 2023, Project Closed
        DNA複製ストレス;ゲノム不安定性;RNA転写;ヘテロクロマチン;ATR;PrimPol;KRAS;肺がん;発がん
      • The roles of R-loop structure in DNA damage signaling and genome
        Grant-in-Aid for Early-Career Scientists
        Basic Section 63020:Radiation influence-related
        The University of Tokyo
        Takaaki Yasuhara
        From 01 Apr. 2018, To 31 Mar. 2022, Discontinued
        R-loop構造;DNA二重鎖切断;DNA損傷シグナリング;DNA修復
      • Mechanism for cancer-related upregulation of the Rad54B-mediated cellular function network
        Grant-in-Aid for Research Activity Start-up
        The University of Tokyo
        Takaaki YASUHARA
        From 28 Aug. 2015, To 31 Mar. 2017, Project Closed
        がん;細胞機能ネットワーク;Rad54B;細胞周期;E2Fファミリー
      • Investigation of the new factors regulating transcription- associated DNA double-strand break repair
        Grant-in-Aid for Scientific Research (B)
        Basic Section 63020:Radiation influence-related
        Kyoto University;The University of Tokyo
        安原 崇哲
        From 01 Apr. 2021, To 31 Mar. 2026, Granted
        染色体転座;がんゲノム異常;DNA修復;転写;DSB修復;R-loop;ゲノム安定性;RAP80
      • 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究
        Grant-in-Aid for Scientific Research (B)
        Basic Section 63020:Radiation influence-related
        Keio University;Gunma University
        柴田 淳史
        From 01 Apr. 2021, To 31 Mar. 2025, Granted
        DNA修復;放射線;NHEJ;HR;DSB修復;クロマチン;転写;染色体転座
      list
        Last Updated :2025/02/12

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Introduction to Biology and Life Science
          N484, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Course in Chromosome Researches
          1027, Spring, Graduate School of Biostudies, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Experiments in Systemic Life Sciences
          5013, Fall, Graduate School of Biostudies, 4
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Experiments in Systemic Life Sciences
          5013, Spring, Graduate School of Biostudies, 4
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar B
          2007, Spring, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar B
          2007, Fall, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar A
          2006, Spring, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar D
          2009, Fall, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar C
          2008, Spring, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar C
          2008, Fall, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar A
          2006, Fall, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course and Seminar D
          2009, Spring, Graduate School of Biostudies, 5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Cancer Biology
          1022, Fall, Graduate School of Biostudies, 2

        Participation in PhD Defense

        • Hes1による発現動態依存的な細胞増殖制御機構の解明
          MAEDA YUKI, Graduate School of Biostudies, Sub-chief Examiner
          24 Nov. 2023
        list
          Last Updated :2025/02/12

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2024
            放射線障害防止委員会
          • From 01 Apr. 2024, To 31 Mar. 2025
            ダイバーシティ推進委員会
          • From 01 Apr. 2024, To 31 Mar. 2025
            同窓会 副会長
          • From 01 Apr. 2024, To 31 Mar. 2025
            改善委員会
          • From 01 Apr. 2024
            将来像検討委員会
          • From 01 Apr. 2024, To 31 Mar. 2025
            高次生命科学副専攻長

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