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Yasuhara, Takaaki
Graduate School of Biostudies, Division of Systemic Life Science Professor
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Last Updated :2025/05/01
Basic Information
Email Address
Email Address
yasuhara.takaaki.7r
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Undergraduate School/Majors)
Research History
- From Jul. 2023, To PresentKyoto University, Graduate School of Biostudies, Professor
- From Apr. 2023, To Jun. 2023The University of Tokyo, Isotope Science Center, Project Lecturer
- From Oct. 2021, To Mar. 2023The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assistant Professor
- From Jun. 2018, To Oct. 2021Massachusetts General Hospital, Cancer Center, Research Fellow
- From Jun. 2018, To May 2020Japan Society for the Promotion of Science, JSPS Overseas Research Fellow
- From Apr. 2015, To Jun. 2018The University of Tokyo, Graduate School of Medicine Center for Disease Biology and Integrative Medicine, Assitant Professor
- From Apr. 2012, To Mar. 2015Japan Society for the Promotion of Science, Research Fellow (DC1)
ID,URL
ORCID ID
J-Global ID
Researcher number
90757056External link
researchmap URL
list
Last Updated :2025/05/01
Research
Research Interests
Research Areas
- Life sciences, Genomics
- Life sciences, Tumor biology
- Life sciences, Radiology
- Environmental science/Agricultural science, Environmental effects of radiation
Papers
- Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaksKie Ozaki; Reona Kato; Takaaki Yasuhara; Yuki Uchihara; Miyako Hirakawa; Yu Abe; Hiroki Shibata; Reika Kawabata-Iwakawa; Aizhan Shakayeva; Palina Kot; Kiyoshi Miyagawa; Keiji Suzuki; Naoki Matsuda; Atsushi Shibata; Motohiro YamauchiScientific Reports, 08 Aug. 2024, Peer-reviewed
- Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent mannerPeter W. T. Lee; Tatsuya Suwa; Minoru Kobayashi; Hui Yang; Lina R. Koseki; Satoshi Takeuchi; Christalle C. T. Chow; Takaaki Yasuhara; Hiroshi HaradaBritish Journal of Cancer, 13 May 2024, Peer-reviewed
- An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stressTaichi Igarashi; Marianne Mazevet; Takaaki Yasuhara; Kimiyoshi Yano; Akifumi Mochizuki; Makoto Nishino; Tatsuya Yoshida; Yukihiro Yoshida; Nobuhiko Takamatsu; Akihide Yoshimi; Kouya Shiraishi; Hidehito Horinouchi; Takashi Kohno; Ryuji Hamamoto; Jun Adachi; Lee Zou; Bunsyo ShiotaniNature Communications, Aug. 2023, Peer-reviewed
- DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production.Yuki Uchihara; Tiara Bunga Mayang Permata; Hiro Sato; Reika Kawabata-Iwakawa; Sayako Katada; Wenchao Gu; Sangeeta Kakoti; Motohiro Yamauchi; Reona Kato; Soehartati Gondhowiardjo; Naoki Hosen; Takaaki Yasuhara; Atsushi ShibataMolecular Cell, 13 May 2022, Peer-reviewed
- Mechanism of chromosome rearrangement arising from single-strand breaksPalina Kot; Takaaki Yasuhara; Atsushi Shibata; Miyako Hirakawa; Yu Abe; Motohiro Yamauchi; Naoki MatsudaBiochemical and Biophysical Research Communications, Oct. 2021, Peer-reviewed
- Impacts of chromatin dynamics and compartmentalization on DNA repair.Takaaki Yasuhara; Lee ZouDNA Repair, Sep. 2021, Peer-reviewed, Invited, Lead author
- High linear energy transfer carbon-ion irradiation upregulates PD-L1 expression more significantly than X-rays in human osteosarcoma U2OS cells.Tiara Bunga Mayang Permata; Hiro Sato; Wenchao Gu; Sangeeta Kakoti; Yuki Uchihara; Yukihiko Yoshimatsu; Itaru Sato; Reona Kato; Motohiro Yamauchi; Keiji Suzuki; Takahiro Oike; Yoshito Tsushima; Soehartati Gondhowiardjo; Tatsuya Ohno; Takaaki Yasuhara; Atsushi ShibataJournal of radiation research, 01 Jul. 2021, Peer-reviewed
- CARM1 regulates replication fork speed and stress response by stimulating PARP1Marie-Michelle Genois; Jean-Philippe Gagné; Takaaki Yasuhara; Jessica Jackson; Sneha Saxena; Marie-France Langelier; Ivan Ahel; Mark T. Bedford; John M. Pascal; Alessandro Vindigni; Guy G. Poirier; Lee ZouMolecular Cell, Feb. 2021, Peer-reviewed
- RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cellsNakako Izumi Nakajima; Motohiro Yamauchi; Sangeeta Kakoti; Liu Cuihua; Reona Kato; Tiara Bunga Mayang Permata; Moito Iijima; Hirohiko Yajima; Takaaki Yasuhara; Shigeru Yamada; Sumitaka Hasegawa; Atsushi ShibataDNA Repair, Jul. 2020, Peer-reviewed
- DNA Repair and Signaling in Immune-Related Cancer Therapy.Sangeeta Kakoti; Hiro Sato; Siddhartha Laskar; Takaaki Yasuhara; Atsushi ShibataFrontiers in molecular biosciences, 2020, Peer-reviewed
- Base excision repair regulates PD-L1 expression in cancer cells.Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Hiro Sato; Takaaki Yasuhara; Takahiro Oike; Soehartati Gondhowiardjo; Kathryn D Held; Takashi Nakano; Atsushi ShibataOncogene, Jun. 2019, Peer-reviewed
- Regulation of PD-L1 expression in response to DNA damage in cancer cells: Implications for precision medicineHiro Sato; Penny A. Jeggo; Atsushi Shibata; Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi ShibataCancer Science, 2019, Peer-reviewed
- p53 deficiency augments nucleolus instability after ionizing irradiation.Sangeeta Kakoti; Motohiro Yamauchi; Wenchao Gu; Reona Kato; Takaaki Yasuhara; Yoshihiko Hagiwara; Siddhartha Laskar; Takahiro Oike; Hiro Sato; Kathryn D. Held; Takashi Nakano; Atsushi Shibata; Corresponding authorOncology Reports, 2019, Peer-reviewed
- Elucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.Atsushi Shibata; Takaaki YasuharaImpact, 2019, Invited
- The role of R-loops in transcription-associated DNA double-strand break repairReona Kato; Kiyoshi Miyagawa; Takaaki YasuharaMolecular Cellular Oncology, Jan. 2019, Peer-reviewed, Invited, Last author, Corresponding author
- Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination RepairTakaaki Yasuhara; Reona Kato; Yoshihiko Hagiwara; Bunsyo Shiotani; Motohiro Yamauchi; Shinichiro Nakada; Atsushi Shibata; Kiyoshi MiyagawaCell, Oct. 2018, Peer-reviewed, Lead author, Corresponding author
- 3D-structured illumination microscopy reveals clustered DNA double-strand break formation in widespread γH2AX foci after high LET heavy-ion particle radiation.Yoshihiko Hagiwara; Atsuko Niimi; Mayu Isono; Motohiro Yamauchi; Takaaki Yasuhara; Siripan Limsirichaikul; Takahiro Oike; Hiro Sato; Kathryn D Held; Takashi Nakano; Atsushi ShibataOncotarget, 12 Dec. 2017, Peer-reviewed
- DNA double-strand break repair pathway regulates PD-L1 expression in cancer cellsHiro Sato; Atsuko Niimi; Takaaki Yasuhara; Tiara Bunga Mayang Permata; Yoshihiko Hagiwara; Mayu Isono; Endang Nuryadi; Ryota Sekine; Takahiro Oike; Sangeeta Kakoti; Yuya Yoshimoto; Kathryn D. Held; Yoshiyuki Suzuki; Koji Kono; Kiyoshi Miyagawa; Takashi Nakano; Atsushi ShibataNature Communications, Nov. 2017, Peer-reviewed
- High RAD54B expression: An independent predictor of postoperative distant recurrence in colorectal cancer patientsYuzo Nagai; Yoko Yamamoto; Takaaki Yasuhara; Keisuke Hata; Takeshi Nishikawa; Toshiaki Tanaka; Junichiro Tanaka; Tomomichi Kiyomatsu; Kazushige Kawai; Hiroaki Nozawa; Shinsuke Kazama; Hironori Yamaguchi; Soichiro Ishihara; Eiji Sunami; Takeharu Yamanaka; Kiyoshi Miyagawa; Toshiaki WatanabeOncotarget, 2015, Peer-reviewed
Presentations
- Aging and chromosome translocations in germline cellsTakaaki YasuharaHIGO最先端研究セミナー, 13 Nov. 2024, Invited
- ゲノム安定性を司る核酸協調のメカニズム安原 崇哲核酸医薬学会第9回年会 シンポジウム, 16 Jul. 2024, Invited
- ジョブハンティングを振り返って ～ いまできる準備をしよう！ ～安原 崇哲第３回 生命科学系３研究科合同セミナー 〜めざせ！近未来のPI〜, 01 Mar. 2024, Invited
- Toward an understanding of how chromosome translocations occurTakaaki YasuharaRadiation Biology Center Mini-symposium, 23 Oct. 2023, Invited
- Genome maintenance by transcription-associated DNA double-strand break repairTakaaki Yasuhara2nd Fukuoka RNA commons, 20 Oct. 2023, Invited
- RNAを介したゲノム安定性維持機構安原崇哲RNAフロンティアミーティング2023, 19 Oct. 2023, Invited
- How Our Genome Is Protected From MutagenesisAsian Young Scientist Fellowship Annual Conference 2023, 16 Oct. 2023, Invited
- Condensates induced by nucleolar stresses mediate gene fusionTakaaki Yasuhara19th Ataxia-Telangiectasia workshop（ATW2023）, 04 Mar. 2023
- Genome maintenance by RNA-mediated stress responsesTakaaki Yasuhara11th International Symposium Gunma University Initiative for Advanced Research, 01 Mar. 2022, Invited
- 凝集体を介したがんゲノム異常発生メカニズム安原崇哲第44回日本分子生物学会年会, Dec. 2021, Invited
- RNA転写とDNA二重鎖切断修復のクロストーク安原崇哲第42回日本分子生物学会年会, Dec. 2019, Invited
- 細胞周期依存的な転写共役型DNA二重鎖切断修復の制御機構安原崇哲日本放射線影響学会第60回大会, Oct. 2017, Invited
- 細胞機能間ネットワークを標的とした新たながん治療戦略安原崇哲第４回 群大Genome Damage Discussion Group公開セミナー, May 2016, Invited
Books and Other Publications
- RNA を介したゲノム安定性の維持機構安原崇哲月刊「アグリバイオ」 2022年 6巻 77-81, Nov. 2022
- ゲノム安定性維持機構におけるarcRNA の役割安原崇哲ニューサイエンス社 月刊「細胞」, Jul. 2022
- Elucidation of the Mechanism Regulating Transcription Associated Dna Double Strand Break Repair and Its PathwayAtsushi Shibata; Takaaki YasuharaImpact 2019 50-51 2019, 2019
Awards
- 04 Dec. 2015若手優秀発表賞(日本分子生物学会・日本生化学会)
- 29 May 2015Young Investigators Award(International Congress of Radiation Research 2015)
- 17 Oct. 2015優秀論文賞(若手放射線生物学研究会)
- 07 Apr. 2023令和5年度科学技術分野の文部科学大臣表彰 若手科学者賞
- 04 May 20232023 Fellow(Asian Young Scientist Fellowship)
External funds: Kakenhi
- Genome instability induced by spatial positions in the nucleusGrant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)Kyoto University;The University of Tokyo安原 崇哲From 01 Apr. 2023, To 31 Mar. 2025, Grantedゲノム脆弱部位;核内位置空間;マッピング法
- A strategy to transform genomic organization and change the gene expression pattern via controlling nucleolar condensatesGrant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)The University of Tokyo安原 崇哲From 16 Jun. 2022, To 31 Mar. 2024, Granted核小体;凝集体;ゲノム構造変換;遺伝子発現誘導;RNA結合タンパク質;液―液相分離
- Investigation of the new factors regulating transcription-associated DNA double-strand break repairGrant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedThe University of Tokyo安原 崇哲From 01 Apr. 2021, To 31 Mar. 2026, Granted染色体転座;DNA修復;転写;がんゲノム異常;DSB修復;R-loop;ゲノム安定性;RAP80
- 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究Grant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedKeio University;Gunma University柴田 淳史From 01 Apr. 2021, To 31 Mar. 2025, GrantedDSB修復;放射線;NHEJ;HR;DNA修復;クロマチン;転写;染色体転座
- 凝集体を介した染色体転座発生メカニズムの解明Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))Basic Section 63020:Radiation influence-relatedThe University of Tokyo安原 崇哲From 01 Apr. 2020, To 31 Mar. 2024, Granted染色体転座;凝集体;転写;がんゲノム異常
- Elucidation of transcription-coupled chromosomal translocation pathways between gene lociGrant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 50:Oncology and related fieldsGunma UniversityAtsushi ShibataFrom 30 Jul. 2020, To 31 Mar. 2023, Project ClosedDNA二本鎖切断;放射線;染色体転座;DNA切断;発がん;転写共役型DNA修復
- Elucidation of the mechanism underlying DNA replication stress response regulating genomic instabilityFund for the Promotion of Joint International Research (Fostering Joint International Research (B))Medium-sized Section 50:Oncology and related fieldsNational Cancer Center JapanBunsyo ShiotaniFrom 07 Feb. 2019, To 31 Mar. 2023, Project ClosedDNA複製ストレス;ゲノム不安定性;RNA転写;ヘテロクロマチン;ATR;PrimPol;KRAS;肺がん;発がん
- The roles of R-loop structure in DNA damage signaling and genomeGrant-in-Aid for Early-Career ScientistsBasic Section 63020:Radiation influence-relatedThe University of TokyoTakaaki YasuharaFrom 01 Apr. 2018, To 31 Mar. 2022, DiscontinuedR-loop構造;DNA二重鎖切断;DNA損傷シグナリング;DNA修復
- Mechanism for cancer-related upregulation of the Rad54B-mediated cellular function networkGrant-in-Aid for Research Activity Start-upThe University of TokyoTakaaki YASUHARAFrom 28 Aug. 2015, To 31 Mar. 2017, Project Closedがん;細胞機能ネットワーク;Rad54B;細胞周期;E2Fファミリー
- Investigation of the new factors regulating transcription- associated DNA double-strand break repairGrant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedKyoto University;The University of Tokyo安原 崇哲From 01 Apr. 2021, To 31 Mar. 2026, Granted染色体転座;がんゲノム異常;DNA修復;転写;DSB修復;R-loop;ゲノム安定性;RAP80
- 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究Grant-in-Aid for Scientific Research (B)Basic Section 63020:Radiation influence-relatedKeio University;Gunma University柴田 淳史From 01 Apr. 2021, To 31 Mar. 2025, GrantedDNA修復;放射線;NHEJ;HR;DSB修復;クロマチン;転写;染色体転座
list
Last Updated :2025/05/01
Education
Teaching subject(s)
- From 01 Apr. 2024, To 31 Mar. 2025Introduction to Biology and Life ScienceN484, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Course in Chromosome Researches1027, Spring, Graduate School of Biostudies, 1
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Experiments in Systemic Life Sciences5013, Fall, Graduate School of Biostudies, 4
- From 01 Apr. 2024, To 31 Mar. 2025Advanced Experiments in Systemic Life Sciences5013, Spring, Graduate School of Biostudies, 4
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar B2007, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar B2007, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar A2006, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar D2009, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar C2008, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar C2008, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar A2006, Fall, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Experimental Course and Seminar D2009, Spring, Graduate School of Biostudies, 5
- From 01 Apr. 2024, To 31 Mar. 2025Cancer Biology1022, Fall, Graduate School of Biostudies, 2
