Basic Information

Academic Degree

• 修士（医学）(北海道大学)
• 博士（医学）(北海道大学)

Academic Resume (Graduate Schools)

• 北海道大学, 大学院医学研究科医学専攻修士課程, 修了
• 北海道大学, 大学院医学研究科医学専攻博士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 北海道大学, 理学部生物科学科, 卒業

High School

• High School

  智辯学園和歌山

ID,URL

• ORCID ID

  0000-0003-3843-3584

• J-Global ID

  201401071382419483

• Researcher number

  40644894

researchmap URL

• https://researchmap.jp/7000009889

Research

Research Topics, Overview of the research

• Research Topics

  Analysis for the regulatory mechanisms and physiological importance of hypoxia response

• Overview of the research

  The environment is extremely diverse in vivo, and each cell maintains itself while adapting to the surrounding microenvironment. In those microenvironment, hypoxia regulates many physiological functions. In our laboratory, the we focus on HIF which is known as master regulator of cellular hypoxic responses and analyze the regulatory mechanisms and physiological importance of hypoxia response.

Research Areas

• Life sciences, Cell biology

Papers

• Fast tumor imaging using pH-responsive aggregation of cyanine dyes with rapid clearance

  Huiying Mu; Shuai Shao; Bingquan Wu; Koji Miki; Minoru Kobayashi; Hiroshi Harada; Kouichi Ohe

  Sensors and Actuators B: Chemical, Aug. 2024, Peer-reviewed

  
• ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1

  Gouki Kambe; Minoru Kobayashi; Hiroshi Ishikita; Sho Koyasu; Ester M. Hammond; Hiroshi Harada

  Biochemical and Biophysical Research Communications, Nov. 2024, Peer-reviewed

  
• Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging

  Iori Tamura; Daichi M. Sakamoto; Bo Yi; Yutaro Saito; Naoki Yamada; Jumpei Morimoto; Yoichi Takakusagi; Masafumi Kuroda; Shimpei I. Kubota; Hiroyuki Yatabe; Minoru Kobayashi; Hiroshi Harada; Kazuki Tainaka; Shinsuke Sando

  Science Advances, 19 Jul. 2024, Peer-reviewed

  
• Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner.

  Lee PWT; Suwa T; Kobayashi M; Yang H; Koseki LR; Takeuchi S; Chow CCT; Takaaki Yasuhara; Hiroshi Harada

  British journal of cancer, 13 May 2024, Peer-reviewed

  
• Hypoxia-Inducible Factor-Dependent and Independent Mechanisms Underlying Chemoresistance of Hypoxic Cancer Cells

  Peter W.T. LEE; Lina Rochelle Koseki; Takao Haitani; Hiroshi Harada; Minoru Kobayashi

  Cancers, 29 Apr. 2024, Corresponding author

  
• Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing.

  Daichi M. Sakamoto; Iori Tamura; Bo Yi; Hasegawa S; Yutaro Saito; Yamada N; Takakusagi Y; Shimpei I. Kubota; Kobayashi M; Harada H; Kenjiro Hanaoka; Masayasu Taki; Nangaku M; Tainaka K; Shinsuke Sando

  ACS nano, 01 Feb. 2024, Peer-reviewed

  
• A reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent

  Kohei Nogita; Takaya Sugahara; Koji Miki; Huiying Mu; Minoru Kobayashi; Hiroshi Harada; Kouichi Ohe

  Chemical Communications, 2024, Peer-reviewed

  
• ZBTB2 is Recruited to a Specific Subset of HIF-1 Target Loci to Facilitate Full Gene Expression Under Hypoxia

  Christalle C.T. Chow; Minoru Kobayashi; Gouki Kambe; Hiroshi Harada

  Journal of Molecular Biology, Aug. 2023, Peer-reviewed

  
• An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor

  Yukari Shirai; Christalle C.T. Chow; Gouki Kambe; Tatsuya Suwa; Minoru Kobayashi; Takahashi Itsuki; Hiroshi Harada; Jin-Min Nam

  Cancers, 04 Jun. 2021

  
• DDX5 enhances HIF‐1 activity by promoting the interaction of HIF‐1α with HIF‐1β and recruiting the resulting heterodimer to its target gene loci

  Yukari SHIRAI; Tatsuya SUWA; Minoru KOBAYASHI; Sho KOYASU; Hiroshi HARADA

  Biology of the Cell, 30 Nov. 2023, Peer-reviewed

  
• ZBTB2 links p53 deficiency to HIF-1-mediated hypoxia signaling to promote cancer aggressiveness.

  Sho Koyasu; Shoichiro Horita; Keisuke Saito; Minoru Kobayashi; Hiroshi Ishikita; Christalle Ct Chow; Gouki Kambe; Shigeto Nishikawa; Toshi Menju; Akiyo Morinibu; Yasushi Okochi; Yoshiaki Tabuchi; Yasuhito Onodera; Norihiko Takeda; Hiroshi Date; Gregg L Semenza; Ester M Hammond; Hiroshi Harada

  EMBO reports, 07 Nov. 2022, Peer-reviewed

  
• SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization.

  Tatsuya Suwa; Minoru Kobayashi; Yukari Shirai; Jin-Min Nam; Yoshiaki Tabuchi; Norihiko Takeda; Shusuke Akamatsu; Osamu Ogawa; Takashi Mizowaki; Ester M Hammond; Hiroshi Harada

  JCI insight, 08 Nov. 2021, Peer-reviewed

  Access this paper :

  
• Proteolysis of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase.

  Takao Haitani; Minoru Kobayashi; Sho Koyasu; Shusuke Akamatsu; Tatsuya Suwa; Yasuhito Onodera; Jin-Min Nam; Phuong Thi Lien Nguyen; Toshi Menju; Hiroshi Date; Osamu Ogawa; Hiroshi Harada

  Cancer letters, 01 Mar. 2022, Peer-reviewed

  
• MS11-3 Th1およびTh17依存的気道アレルギーにおける気道過敏性上昇機構の解明(気管支喘息-病態生理,第58回日本アレルギー学会秋季学術大会)

  芦野 滋; 小林 稔; 茶本 健司; 冨樫 裕二; 北村 秀光; 西村 孝司

  アレルギー, 2008

  
• Tumor microenvironment and radioresistance

  Tatsuya Suwa; Minoru Kobayashi; Jin-Min Nam; Hiroshi Harada

  Experimental & Molecular Medicine, 16 Jun. 2021

  
• 酸素環境検知の基本メカニズムとがん

  小林 稔、原田 浩

  実験医学, Jun. 2020, Lead author

  
• Space Radiation Biology for “Living in Space”

  Satoshi Furukawa; Aiko Nagamatsu; Mitsuru Nenoi; Akira Fujimori; Shizuko Kakinuma; Takanori Katsube; Bing Wang; Chizuru Tsuruoka; Toshiyuki Shirai; Asako J. Nakamura; Asako Sakaue-Sawano; Atsushi Miyawaki; Hiroshi Harada; Minoru Kobayashi; Junya Kobayashi; Takekazu Kunieda; Tomoo Funayama; Michiyo Suzuki; Tatsuo Miyamoto; Jun Hidema; Yukari Yoshida; Akihisa Takahashi

  BioMed Research International, 08 Apr. 2020

  
• HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance.

  Ayako Nagao; Minoru Kobayashi; Sho Koyasu; Christalle C T Chow; Hiroshi Harada

  International journal of molecular sciences, 09 Jan. 2019, Peer-reviewed

  Access this paper :

  
• Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.

  Sho Koyasu; Minoru Kobayashi; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  Cancer science, Mar. 2018, Peer-reviewed

  Access this paper :

  
• HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog

  Tomohiro Katagiri; Minoru Kobayashi; Michio Yoshimura; Akiyo Morinibu; Satoshi Itasaka; Masahiro Hiraoka; Hiroshi Harada

  Oncotarget, 2018, Peer-reviewed

  
• UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

  Ryota Nakashima; Yoko Goto; Sho Koyasu; Minoru Kobayashi; Akiyo Morinibu; Michio Yoshimura; Masahiro Hiraoka; Ester M. Hammond; Hiroshi Harada

  Scientific Reports, 01 Dec. 2017, Peer-reviewed

  Access this paper :

  
• A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1 alpha to promoter regions of its downstream genes

  Minoru Kobayashi; Akiyo Morinibu; Sho Koyasu; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  FEBS JOURNAL, Nov. 2017, Peer-reviewed, Lead author

  
• The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies

  Yoko Goto; Sho Koyasu; Minoru Kobayashi; Hiroshi Harada

  MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Oct. 2017, Peer-reviewed

  
• UCHL1-HIF-1経路による抗酸化作用は放射線治療効果の増強に資する標的となり得る

  中島 良太; 後藤 容子; 子安 翔; 小林 稔; 吉村 通央; 平岡 眞寛; 原田 浩

  日本癌学会総会記事, Sep. 2017, Peer-reviewed

  
• がんの遠隔転移発生率を予測する新規バイオマーカーUCHL1-HIF-1に関する研究

  原田 浩; 吉村 通央; 小林 稔

  大和証券ヘルス財団研究業績集, Mar. 2017, Peer-reviewed

  
• LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

  Chan Joo Yeom; Lihua Zeng; Yoko Goto; Akiyo Morinibu; Yuxi Zhu; Kazumi Shinomiya; Minoru Kobayashi; Satoshi Itasaka; Michio Yoshimura; Cheol-Goo Hur; Hideaki Kakeya; Ester M. Hammond; Masahiro Hiraoka; Hiroshi Harada

  ONCOTARGET, Oct. 2016, Peer-reviewed

  Access this paper :

  
• PLK1の阻害はM期集積を介して放射線増感効果を誘導する

  小林 稔; 井上 実; 吉村 通央; 平岡 真寛; 原田 浩

  放射線ワークショップ講演論文集, Oct. 2015, Peer-reviewed

  
• 時計遺伝子PER2と低酸素誘導因子1(HIF-1)の相互作用メカニズムの解析

  小林 稔; 後藤 容子; 吉村 通央; 平岡 真寛; 原田 浩

  日本癌学会総会記事, Oct. 2015, Peer-reviewed

  
• UCHL1はHIF-1αの脱ユビキチン化を介してがんの遠隔転移を亢進する

  後藤 容子; 小林 稔; 板坂 聡; 吉村 通央; 平岡 真寛; 原田 浩

  日本癌学会総会記事, Oct. 2015, Peer-reviewed

  
• HIF-1はSHHの分泌を亢進し、間質細胞豊富な膵臓がん微小環境を形成する

  片桐 幸大; 原田 浩; 吉村 通央; 小林 稔; 平岡 真寛

  日本癌学会総会記事, Oct. 2015, Peer-reviewed

  
• PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase

  Minoru Inoue; Michio Yoshimura; Minoru Kobayashi; Akiyo Morinibu; Satoshi Itasaka; Masahiro Hiraoka; Hiroshi Harada

  SCIENTIFIC REPORTS, Oct. 2015, Peer-reviewed

  Access this paper :

  
• Aberrant IDH3 alpha expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

  L. Zeng; A. Morinibu; M. Kobayashi; Y. Zhu; X. Wang; Y. Goto; C. J. Yeom; T. Zhao; K. Hirota; K. Shinomiya; S. Itasaka; M. Yoshimura; G. Guo; E. M. Hammond; M. Hiraoka; H. Harada

  ONCOGENE, Sep. 2015, Peer-reviewed

  
• UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha

  Yoko Goto; Lihua Zeng; Chan Joo Yeom; Yuxi Zhu; Akiyo Morinibu; Kazumi Shinomiya; Minoru Kobayashi; Kiichi Hirota; Satoshi Itasaka; Michio Yoshimura; Keiji Tanimoto; Masae Torii; Terumasa Sowa; Toshi Menju; Makoto Sonobe; Hideaki Kakeya; Masakazu Toi; Hiroshi Date; Ester M. Hammond; Masahiro Hiraoka; Hiroshi Harada

  Nature Communications, Jan. 2015, Peer-reviewed

  Access this paper :

  
• PLK1阻害剤(TAK-960)が有するmitotic arrest誘導作用による放射線増感(A novel small molecule inhibitor of PLK1, TAK-960, sensitizes therapeutic effect of radiation by inducing mitotic arrest)

  井上 実; 吉村 通央; 小林 稔; 板坂 聡; 本田 弘平; 平岡 真寛; 原田 浩

  日本癌学会総会記事, Sep. 2014, Peer-reviewed

  
• HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs

  Tao Zhao; Yuxi Zhu; Akiyo Morinibu; Minoru Kobayashi; Kazumi Shinomiya; Satoshi Itasaka; Michio Yoshimura; Guozheng Guo; Masahiro Hiraoka; Hiroshi Harada

  SCIENTIFIC REPORTS, Jan. 2014, Peer-reviewed

  
• 低酸素ストレスとHIF

  小林 稔; 原田 浩

  生化学, 2013, Peer-reviewed, Lead author

  
• Neuropeptide Signaling Activates Dendritic Cell-Mediated Type 1 Immune Responses through Neurokinin-2 Receptor

  Hidemitsu Kitamura; Minoru Kobayashi; Daiko Wakita; Takashi Nishimura

  JOURNAL OF IMMUNOLOGY, May 2012, Peer-reviewed

  
• IFN-gamma elevates airway hyper-responsiveness via up-regulation of neurokinin A/neurokinin-2 receptor signaling in a severe asthma model

  Minoru Kobayashi; Shigeru Ashino; Yasuo Shiohama; Daiko Wakita; Hidemitsu Kitamura; Takashi Nishimura

  EUROPEAN JOURNAL OF IMMUNOLOGY, Feb. 2012, Peer-reviewed, Lead author

  
• The role of Th17 cells for the induction of airway hyperresponsiveness: comparison with Th1/Th2-dependent airway inflammation

  西村 孝司; 小林 稔; 脇田 大功; 北村; 秀光; 芦野 茂

  Clinical immunology & allergology, 2010, Peer-reviewed

  

Misc.

• [Hypoxic stress and HIF].

  Minoru Kobayashi; Hiroshi Harada

  Seikagaku. The Journal of Japanese Biochemical Society, 2013

  
• 抗腫瘍エフェクター細胞 新規Survivin由来ヘルパーペプチドの同定と免疫不全マウスを用いたTh1細胞治療モデルの確立

  大栗 敬幸; 野口 大輔; 小林 稔; 増子 和尚; 大竹 淳矢; 脇田 大功; 茶本 健司; 北村 秀光; 富樫 裕二; 西村 孝司

  日本がん免疫学会総会プログラム・抄録集, Jun. 2009

  
• 時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析

  小林 稔; 平岡; 真寛; 原田 浩

  2014

  
• IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する

  小林 稔; 曽 麗華; 後藤 容子; 井上 実; 板坂 聡; 吉村 通央; 原田 浩; 平岡 真寛

  2013

  
• Method for establishment of cancer stem-like cells by introduction of oncogenes into mesenchymal stem cells

  小林 稔; 脇田 大功; 岩淵 禎弘; 佐藤 崇之; 北村; 秀光; 西村 孝司

  2013

  
• Establishment of airway smooth muscle cell line useful for evaluating neuro-immuno cross-talk in Th1-mediated airway inflammation.

  KOBAYASHI Minoru; ASHINO Shigeru; SUZUKI Ikurou; KITAMURA Hidemitsu; YASUDA Kenji; NISHIMURA Takashi

  2011

  
• The pivotal role of IFN-gamma in Th1- and Th17-mediated steroid-resistant airway hyperresponsiveness.

  Minoru Kobayashi; Shigeru Ashino; Hidemitsu Kitamura; Takashi Nishimura

  2010

  
• 新規Survivinヘルパーペプチドの同定と免疫不全マウスを用いたSurvivin特異的Th1細胞による抗腫瘍効果の検討(Identification of novel helper epitopes of Survivin and antitumor effects of human Th1 cells in immunodeficient mice)

  大栗 敬幸; 野口 大輔; 小林 稔; 増子 和尚; 大竹 淳矢; 脇田 大功; 茶本 健司; 富樫 裕二; 北村 秀光; 西村 孝司

  日本癌学会総会記事, Aug. 2009

  
• Identification of novel helper epitopes of MAGE-A4 and Survivin tumor antigen: Useful tool for the propagation of Th1 cells

  Takayuki Ohkuri; Daiko Wakita; Daisuke Noguchi; Minoru Kobayashi; Kazutaka Masuko; Junya Ohtake; Kenji Chamoto; Yuji Togashi; Hidemitsu Kitamura; Takashi Nishimura

  CANCER RESEARCH, May 2009

  

Presentations

• Decreased expression levels of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase

  灰谷 崇夫; 小林 稔; 原田 浩

  第18回がんとハイポキシア研究会, 06 Nov. 2022

  
• DNA double strand breaksのインビボ定量評価に向けたEGFP-53BP1ノックインマウスの樹立

  Minoru Kobayashi; Hiroshi Harada

  第62回 日本放射線影響学会, 2019

  
• A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of Its Downstream Genes

  Minoru Kobayashi; Akiyo Morinibu; Sho Koyasu; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  第34回放生研国際シンポジウム, 2018

  
• HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating Shh.

  Minoru Kobayashi; Tomohiro Katagiri; Masahiro Hiraoka; Hiroshi Harada

  第77回 日本癌学会学術総会, 2018

  
• A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of Its downstream genes

  Minoru Kobayashi; Akiyo Morinibu; Sho Koyasu; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  The 17th International Joint Mini-Symposium on Molecular and Cell Biology, 2018

  
• A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of Its downstream genes

  Minoru Kobayashi; Akiyo Morinibu; Sho Koyasu; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  Keystone symposia Therapeutic Targeting of Hypoxia-Sensitive Pathways (V1), 2018

  
• A Circadian Clock Gene, PER2, Activates HIF-1 as an Effector Molecule for Recruitment of HIF-1α to Promoter Regions of Its Downstream Genes

  Minoru KOBAYASHI; Akiyo MORINIBU; Sho KOYASU; Yoko GOTO; Masahiro HIRAOKA; Hiroshi Harada

  第33回放生研国際シンポジウム, 2017

  
• A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1α to promoter regions of its downstream genes.

  小林 稔; 森鳰 章代; 子安 翔; 後藤 容子; 平岡 真寛; 原田 浩

  第15回 がんとハイポキシア研究会, 2017

  
• Molecular mechanisms underlying the crosstalk between period circadian clock 2 (PER2) and hypoxia-inducible factor 1 (HIF-1)

  Minoru Kobayashi; Syo Koyasu; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  第76回 日本癌学会学術総会, 2017

  
• Period circadian clock 2 activates hypoxia-inducible factor 1 by promoting recruitment of HIF-1α to its downstream promoter

  Minoru Kobayashi; Akiyo Morinibu; Sho Koyasu; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  keystone symposium Adaptations to Hypoxia in Physiology and Disease (X4), 2017

  
• Molecular mechanisms underlying the crosstalk between period circadian clock 2 (PER2) and hypoxia-inducible factor 1 (HIF-1)

  小林 稔; 森鳰 章代; 子安 翔; 後藤 容子; 平岡 真寛; 原田 浩

  第14回 がんとハイポキシア研究会, 2016

  
• Molecular mechanisms underlying the crosstalk between circadian clock gene, PER2, and hypoxia-inducible factor 1 (HIF-1)

  Minoru Kobayashi; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  第75回 日本癌学会学術総会, 2016

  
• Molecular mechanisms underlying the crosstalk between circadian clock gene, PER2, and hypoxia-inducible factor 1 (HIF-1).

  Minoru Kobayashi; Yoko Goto; Michio Yoshimura; Masahiro Hiraoka; Hiroshi Harada

  第32回放生研国際シンポジウム, 2016

  
• IDH3-HIF-1経路によるがん細胞の糖代謝リプログラミング

  小林 稔; 曽 麗華; 後藤 容子; 広田 喜一; 平岡 真寛; 原田 浩

  Biochemistry and Molecular Biology, 2015, Invited

  
• Molecular mechanisms underlying the crosstalk between circadian clock gene, PRE2, and hypoxia-inducible factor 1 (HIF-1).

  Minoru Kobayashi; Yoko Goto; Michio, Yoshimura; Masahiro Hiraoka; Hiroshi Harada

  第74回 日本癌学会学術総会, 2015

  
• 時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析

  小林 稔; 後藤 容子; 平岡 真寛; 原田 浩

  第13回 がんとハイポキシア研究会, 2015

  
• Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.

  Minoru Kobayashi; Hiraoka Masahiro; Harada Hiroshi

  15th International Congress of Radiation Research., 2015

  
• 時計遺伝子PER2と低酸素応答機構の相互作用メカニズムの解析

  小林 稔; 平岡 真寛; 原田 浩

  第12回 がんとハイポキシア研究会, 2014

  
• Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels.

  Minoru KOBAYASHI; Masahiro HIRAOKA; Hiroshi HARADA

  Radiation Research Society 60th Annual Meeting, 2014

  
• Method for establishment of cancer stem-like cells by introduction of oncogenes into mesenchymal stem cells

  小林 稔; 脇田 大功; 岩淵 禎弘; 佐藤 崇之; 北村; 秀光; 西村 孝司

  第70回 日本癌学会学術総会, 2011

  
• The pivotal role of IFN-γ in Th1- and Th17-mediated steroid-resistant airway hyperresponsiveness

  Minoru Kobayashi; Shigeru Ashino; Hidemitsu Kitamura; Takashi Nishimura

  第14回国際免疫学会議, 2010

  
• Establishment of airway smooth muscle cell line useful for evaluating neuro-immuno cross-talk in Th1-mediated airway inflammation

  KOBAYASHI Minoru; ASHINO Shigeru; SUZUKI Ikurou; KITAMURA Hidemitsu; YASUDA Kenji; NISHIMURA Takashi

  第38回 日本免疫学会総会・学術集会, 2008

  

External funds: Kakenhi

• Genome-wide screening of blood markers for hypoxic cancer cells within malignant solid tumors

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  Hiroshi Harada

  From 09 Jul. 2021, To 31 Mar. 2023, Project Closed

  がん;微小環境;低酸素;マーカー;が

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19445/
• 新規リアルタイムDNA損傷修復応答検出システムの構築と腫瘍内DNA損傷応答の解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  小林 稔

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  DNA損傷修復;In vivo imaging

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07727/
• A novel invasion-related gene involved in tumor recurrence after radiation therapy

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  Hiroshi Harada

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  がん;低酸素;浸潤・転移関連遺伝子;放射線治療;放射線抵抗性;HIF-1;再発;浸潤;抵抗性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22595/
• Mechanism of Action and Function of a novel HIF-1 activator in p53-deficient cancers

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  Hiroshi Harada

  From 09 Oct. 2018, To 31 Mar. 2021, Project Closed

  がん;低酸素;浸潤・転移関連遺伝子;治療抵抗性;がん抑制遺伝子;HIF-1;p53;浸潤;Sima;放射線

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0241/
• Development of novel therapies targeting the dynamics of tumor microenvironment and HIF-1

  Grant-in-Aid for Early-Career Scientists

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  Minoru Kobayashi

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  低酸素;腫瘍内微小環境;放射線抵抗性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15589/
• Novel gene network responsible for hypoxic response and radioresistance of cancer cells

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akiyo Morinibu

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  がん;放射線;低酸素;放射線抵抗性;放射線治療;放射線抵抗壊死;新規責任遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10474/
• Interplay between the molecular mechanism for hypoxia response and that for antioxidant capacity

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  がん;低酸素応答;抗酸化能;放射線抵抗性;血中マーカー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04261/
• Search for factors inducing radioresistance using lentivirus libraries

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Minoru Kobayashi

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  放射線抵抗性;遺伝子スクリーニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15577/
• Spatiotemporal analyses of the dynamics of hypoxic tumor cells for the optimization of fractionated radiation therapy for cancers

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  がん;放射線治療;分割照射;腫瘍内低酸素;HIF-1;放射線治療抵抗性;低酸素;細胞動態

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670558/
• Molecular Mechanisms behind Cancer Cells-specific Oxygen Homeostasis and Their Influence on Tumor Radioresistance

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  放射線治療;がん;治療抵抗性;酸素恒常性;エネルギー代謝;HIF-1;低酸素;微小環境;放射線治療抵抗性;低酸素応答

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293276/
• Elucidation of mechanisms for tumor malignancy and radioresistance by crosstalk between Hypoxia, circadian rhythm and metabolic regulation

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  minoru KOBAYASHI

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  低酸素;概日リズム;放射線抵抗性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25861088/
• がん個別化放射線治療法の確立に向けたTR研究

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  原田 浩

  From 07 Oct. 2021, To 31 Mar. 2024, Granted

  がん;放射線治療;微小環境;低酸素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21KK0144/
• 放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  原田 浩

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  がん;低酸素;マーカー;微小環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02855/
• Identification of stromal subcellular population which exhiites active HIF signaling and is responsible for radioresistance of cancer

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  原田 浩

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  がん;放射線;低酸素;ストローマ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18274/
• 放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  原田 浩

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  がん;低酸素;マーカー;微小環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27546/

Administration

Faculty management (title, position)

• From 01 Oct. 2022

  人材育成企画室
• From 01 Apr. 2021

  安全・環境保全委員会　委員
• From 01 Apr. 2021

  衛生管理者