Researchers Information System

日本語に切り替えるswitch to english

Search for faculty members

Advanced SearchSearch by organization

Nozawa, Takashi

Graduate School of Medicine, Medicine Associate Professor

Nozawa, Takashi
list
    Last Updated :2025/05/27

    Basic Information

    Faculty

    • 医学部

    Academic Degree

    • 修士（農学）(新潟大学)
    • 博士（生命科学）(東京大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/27

      Research

      Research Topics, Overview of the research

      • Research Topics

        Interaction of bacterial pathogens and host membrane trafficking

      • Overview of the research

        Many pathogenic microbes invade into host cells and proliferate. In contrast, host cells defend cells through membrane trafficking pathways such as endosome-lysosome and autophagy. We focus on and investigate the interaction of membrane trafficking and pathogenic bacteria to reveal the mechanisms of infectious disease and intracellular immunity.

      Research Areas

      • Life sciences, Bacteriology

      Papers

      • Complete genome sequence of three Staphylococcus epidermidis strains isolated from patients with skin diseases in Japan.
        Yu Kawagishi; Teresia M Kimeu; Kazunori Murase; Akemi Yoshida; Atsuko Minowa-Nozawa; Takashi Nozawa; Yasuhiro Tsuchido; Taro Noguchi; Miki Nagao; Saeko Nakajima; Ichiro Nakagawa
        Microbiology resource announcements, 20 Jun. 2024
      • ATG9B regulates bacterial internalization via actin rearrangement.
        Junpei Iibushi; Takashi Nozawa; Hirotaka Toh; Ichiro Nakagawa
        iScience, 17 May 2024
      • Guanylate-Binding Protein 1 Regulates Infection-Induced Autophagy through TBK1 Phosphorylation
        Miyako Hikichi; Hirotaka Toh; Atsuko Minowa-Nozawa; Takashi Nozawa; Ichiro Nakagawa
        Cellular Microbiology, 2022
      • Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy
        Takashi Nozawa; Hirotaka Toh; Junpei Iibushi; Kohei Kogai; Atsuko Minowa-Nozawa; Junko Satoh; Shinji Ito; Kazunori Murase; Ichiro Nakagawa
        Nature Communications, 06 Oct. 2023
      • Group A Streptococcus cation diffusion facilitator proteins contribute to immune evasion by regulating intracellular metal concentrations.
        Chihiro Aikawa; Akihide Shimizu; Makoto Nakakido; Kazunori Murase; Takashi Nozawa; Kouhei Tsumoto; Ichiro Nakagawa
        Biochemical and biophysical research communications, 24 Jul. 2023
      • FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan.
        Akihiro Yamada; Miyako Hikichi; Takashi Nozawa; Ichiro Nakagawa
        EMBO reports, 04 Nov. 2021
      • Streptococcus suisのヒト及びブタ細胞における細胞毒性およびオートファジー誘導に関する検討
        黒木 香澄; 野澤 孝志; 渡辺 孝康; Kim Hyunjung; 鈴木 詠律子; 中川 一路; 関崎 勉
        日本細菌学雑誌, Feb. 2018
      • Biological Effect of Streptococcus pyogenes-Released Extracellular Vesicles on Human Monocytic Cells, Induction of Cytotoxicity, and Inflammatory Response
        Kazunori Murase; Chihiro Aikawa; Takashi Nozawa; Ayako Nakatake; Kuniyo Sakamoto; Taisei Kikuchi; Ichiro Nakagawa
        Frontiers in Cellular and Infection Microbiology, 19 Jul. 2021
      • Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy.
        Hirotaka Toh; Takashi Nozawa; Atsuko Minowa-Nozawa; Miyako Hikichi; Shintaro Nakajima; Chihiro Aikawa; Ichiro Nakagawa
        Autophagy, Feb. 2020, Peer-reviewed
      • LAMTOR2/LAMTOR1 complex is required for TAX1BP1-mediated xenophagy.
        Lin CY; Nozawa T; Minowa-Nozawa A; Toh H; Aikawa C; Nakagawa I
        Cellular microbiology, Apr. 2019, Peer-reviewed
      • RAB30 regulates PI4KB (phosphatidylinositol 4-kinase beta)-dependent autophagy against group A Streptococcus.
        Nakajima K; Nozawa T; Minowa-Nozawa A; Toh H; Yamada S; Aikawa C; Nakagawa I
        Autophagy, Mar. 2019, Peer-reviewed
      • Phylogenetic relationship of prophages is affected by CRISPR selection in Group A Streptococcus.
        Shunsuke Yamada; Masaki Shibasaki; Kazunori Murase; Takayasu Watanabe; Chihiro Aikawa; Takashi Nozawa; Ichiro Nakagawa
        BMC microbiology, 28 Jan. 2019, Peer-reviewed
        Access this paper :
      • NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1-UVRAG Complex.
        Chihiro Aikawa; Shintaro Nakajima; Miho Karimine; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Shunsuke Yamada; Ichiro Nakagawa
        Frontiers in cellular and infection microbiology, 2018, Peer-reviewed
        Access this paper :
      • Rab35 GTPase recruits NDP52 to autophagy targets (vol 36, pg 2790, 2017)
        Atsuko Minowa-Nozawa; Takashi Nozawa; Keiko Okamoto-Furuta; Haruyasu Kohda; Ichiro Nakagawa
        EMBO JOURNAL, Nov. 2017, Peer-reviewed
      • Rab35 GTPase recruits NDP52 to autophagy targets (vol 36, pg 2790, 2017)
        Atsuko Minowa-Nozawa; Takashi Nozawa; Keiko Okamoto-Furuta; Haruyasu Kohda; Ichiro Nakagawa
        EMBO JOURNAL, Nov. 2017, Peer-reviewed
      • A Locus Encoding Variable Defense Systems against Invading DNA Identified in Streptococcus suis
        Masatoshi Okura; Takashi Nozawa; Takayasu Watanabe; Kazunori Murase; Ichiro Nakagawa; Daisuke Takamatsu; Makoto Osaki; Tsutomu Sekizaki; Marcelo Gottschalk; Shigeyuki Hamada; Fumito Maruyama
        GENOME BIOLOGY AND EVOLUTION, Apr. 2017, Peer-reviewed
        Access this paper :
      • The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes
        Takashi Nozawa; Atsuko Minowa-Nozawa; Chihiro Aikawa; Ichiro Nakagawa
        AUTOPHAGY, 2017, Peer-reviewed
        Access this paper :
      • Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG
        Shintaro Nakajima; Chihiro Aikawe; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Ichiro Nakagawa
        PLOS ONE, Jan. 2017, Peer-reviewed
        Access this paper :
      • YvqE and CovRS of Group A Streptococcus Play a Pivotal Role in Viability and Phenotypic Adaptations to Multiple Environmental Stresses
        Amonrattana Roobthaisong; Chihiro Aikawa; Takashi Nozawa; Fumito Maruyama; Ichiro Nakagawa
        PLOS ONE, Jan. 2017, Peer-reviewed
        Access this paper :
      • The intracellular microbial sensor NLRP4 directs Rho-actin signaling to facilitate Group A Streptococcus-containing autophagosome-like vacuole formation
        Takashi Nozawa; Chihiro Aikawa; Atsuko Minowa-Nozawa; Ichiro Nakagawa
        AUTOPHAGY, 2017, Peer-reviewed
      • DNA-based culture-independent analysis detects the presence of group a streptococcus in throat samples from healthy adults in Japan
        Tejaswini Kulkarni; Chihiro Aikawa; Takashi Nozawa; Kazunori Murase; Fumito Maruyama; Ichiro Nakagawa
        BMC MICROBIOLOGY, Oct. 2016, Peer-reviewed
        Access this paper :
      • Golgi-Resident GTPase Rab30 Promotes the Biogenesis of Pathogen-Containing Autophagosomes
        Seiichiro Oda; Takashi Nozawa; Atsuko Nozawa-Minowa; Misako Tanaka; Chihiro Aikawa; Hiroyuki Harada; Ichiro Nakagawa
        PLOS ONE, Jan. 2016, Peer-reviewed
        Access this paper :
      • Comparative genome analysis and identification of competitive and cooperative interactions in a polymicrobial disease
        Akiko Endo; Takayasu Watanabe; Nachiko Ogata; Takashi Nozawa; Chihiro Aikawa; Shinichi Arakawa; Fumito Maruyama; Yuichi Izumi; Ichiro Nakagawa
        ISME JOURNAL, Mar. 2015, Peer-reviewed
      • Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion
        Bijaya Haobam; Takashi Nozawa; Atsuko Minowa-Nozawa; Misako Tanaka; Seiichiro Oda; Takayasu Watanabe; Chihiro Aikawa; Fumito Maruyama; Ichiro Nakagawa
        CELLULAR MICROBIOLOGY, Dec. 2014, Peer-reviewed
      • Endogenous Nitrated Nucleotide Is a Key Mediator of Autophagy and Innate Defense against Bacteria
        Chiaki Ito; Yohei Saito; Takashi Nozawa; Shigemoto Fujii; Tomohiro Sawa; Hirofumi Inoue; Tetsuro Matsunaga; Shahzada Khan; Soichiro Akashi; Ryota Hashimoto; Chihiro Aikawa; Eriko Takahashi; Hiroshi Sagara; Masaaki Komatsu; Keiji Tanaka; Takaaki Akaike; Ichiro Nakagawa; Hirokazu Arimoto
        MOLECULAR CELL, Dec. 2013, Peer-reviewed
      • Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation
        Masatoshi Okura; Daisuke Takamatsu; Fumito Maruyama; Takashi Nozawa; Ichiro Nakagawa; Makoto Osaki; Tsutomu Sekizaki; Marcelo Gottschalk; Yumi Kumagai; Shigeyuki Hamada
        APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Apr. 2013, Peer-reviewed
      • CRISPR Regulation of Intraspecies Diversification by Limiting IS Transposition and Intercellular Recombination
        Takayasu Watanabe; Takashi Nozawa; Chihiro Aikawa; Atsuo Amano; Fumito Maruyama; Ichiro Nakagawa
        GENOME BIOLOGY AND EVOLUTION, 2013, Peer-reviewed
      • The small GTPases Rab9A and Rab23 function at distinct steps in autophagy during Group A Streptococcus infection
        Takashi Nozawa; Chihiro Aikawa; Akira Goda; Fumito Maruyama; Shigeyuki Hamada; Ichiro Nakagawa
        CELLULAR MICROBIOLOGY, Aug. 2012, Peer-reviewed
      • Complete Genome Sequence of the Bacterium Porphyromonas gingivalis TDC60, Which Causes Periodontal Disease
        Takayasu Watanabe; Fumito Maruyama; Takashi Nozawa; Akinobu Aoki; Soichiro Okano; Yasuko Shibata; Kenshiro Oshima; Ken Kurokawa; Masahira Hattori; Ichiro Nakagawa; Yoshimitsu Abiko
        JOURNAL OF BACTERIOLOGY, Aug. 2011, Peer-reviewed
      • CRISPR Inhibition of Prophage Acquisition in Streptococcus pyogenes
        Takashi Nozawa; Nayuta Furukawa; Chihiro Aikawa; Takayasu Watanabe; Bijaya Haobam; Ken Kurokawa; Fumito Maruyama; Ichiro Nakagawa
        PLOS ONE, May 2011, Peer-reviewed
      • Specific Behavior of Intracellular Streptococcus pyogenes That Has Undergone Autophagic Degradation Is Associated with Bacterial Streptolysin O and Host Small G Proteins Rab5 and Rab7
        Atsuo Sakurai; Fumito Maruyama; Junko Funao; Takashi Nozawa; Chihiro Aikawa; Nobuo Okahashi; Seikou Shintani; Shigeyuki Hamada; Takashi Ooshima; Ichiro Nakagawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2010, Peer-reviewed
      • Reactive oxygen species induced by Streptococcus pyogenes invasion trigger apoptotic cell death in infected epithelial cells
        Chihiro Aikawa; Takashi Nozawa; Fumito Maruyama; Kohei Tsumoto; Shigeyuki Hamada; Ichiro Nakagawa
        CELLULAR MICROBIOLOGY, Jun. 2010, Peer-reviewed
      • Cost effective DNA sequencing and template preparation from bacterial colonies and plasmids
        Fumito Maruyama; Takashi Nozawa; Chihiro Aikawa; Atsuo Sakurai; Ichiro Nakagawa
        JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Apr. 2009, Peer-reviewed
      • Swarming of Pseudomonas aeruginosa PAO1 without differentiation into elongated hyperflagellates on hard agar minimal medium
        Chihiro Takahashi; Takashi Nozawa; Taichiro Tanikawa; Yoji Nakagawa; Junichi Wakita; Mitsugu Matsushita; Tohey Matsuyama
        FEMS MICROBIOLOGY LETTERS, Mar. 2008, Peer-reviewed
      • Distinct function of Pseudomonas aeruginosa type IV pili disclosed in the bacterial pass-through of membrane filter with smaller pore sizes
        Hiroyuki Hasegawa; Taichiro Tanikawa; Takashi Nozawa; Kentaro Nakazawa; Yoji Nakagawa; Tohey Matsuyama
        MICROBIOLOGY AND IMMUNOLOGY, 2007, Peer-reviewed
      • Rhamnolipid-dependent spreading growth of pseudomonas aeruginosa on a high-agar medium: marked enhancement under CO2-rich anaerobic conditions
        Takashi Nozawa; Taichiro Tanikawa; Hiroyuki Hasegawa; Chihiro Takahashi; Yumi Ando; Mitsugu Matsushita; Yoji Nakagawa; Tohey Matsuyama
        MICROBIOLOGY AND IMMUNOLOGY, 2007, Peer-reviewed
      • Single-chain variable fragment (scFv) targeting streptolysin O controls group A Streptococcus infection.
        Chihiro Aikawa; Kiyosumi Kawashima; Chihiro Fukuzaki; Makoto Nakakido; Kazunori Murase; Takashi Nozawa; Kouhei Tsumoto; Ichiro Nakagawa
        Biochemical and biophysical research communications, 20 Aug. 2021
      • Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase.
        Takashi Nozawa; Junpei Iibushi; Hirotaka Toh; Atsuko Minowa-Nozawa; Kazunori Murase; Chihiro Aikawa; Ichiro Nakagawa
        mBio, 09 Feb. 2021
        Access this paper :
      • Complete Genome Sequences of Two Streptococcus suis Strains Isolated from Asymptomatic Pigs.
        Atsuko Minowa-Nozawa; Takashi Nozawa; Daisuke Takamatsu; Akemi Yoshida; Kazunori Murase; Taisei Kikuchi; Kasumi Ishida-Kuroki; Yoshihiro Nitta; Tsutomu Sekizaki; Ichiro Nakagawa
        Microbiology resource announcements, 19 Nov. 2020
      • Complete Genome Sequences of Streptococcus pyogenes Serotype M3, M28, and M89 Strains Isolated from Human Patients in Japan, 1994 to 2009.
        Kazunori Murase; Takashi Nozawa; Chihiro Aikawa; Miki Nagao; Tadayoshi Ikebe; Akemi Yoshida; Taisei Kikuchi; Ichiro Nakagawa
        Microbiology resource announcements, 15 Oct. 2020
      • Complete Genome Sequences of Streptococcus pyogenes Serotype M3, M28, and M89 Strains Isolated from Human Patients in Japan, 1994 to 2009
        Kazunori Murase; Takashi Nozawa; Chihiro Aikawa; Miki Nagao; Tadayoshi Ikebe; Akemi Yoshida; Taisei Kikuchi; Ichiro Nakagawa
        MICROBIOLOGY RESOURCE ANNOUNCEMENTS, Oct. 2020
      • Identification of Group A Streptococcus-Containing Autophagosome-Like Vacuoles.
        Takashi Nozawa; Ichiro Nakagawa
        Methods in molecular biology (Clifton, N.J.), 2020
      • Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection.
        Ching-Yu Lin; Takashi Nozawa; Atsuko Minowa-Nozawa; Hirotaka Toh; Miyako Hikichi; Junpei Iibushi; Ichiro Nakagawa
        Frontiers in cellular and infection microbiology, 2020
      • Complete Genome Sequences of Eight Methicillin-Resistant Staphylococcus aureus Strains Isolated from Patients in Japan.
        Miyako Hikichi; Miki Nagao; Kazunori Murase; Chihiro Aikawa; Takashi Nozawa; Akemi Yoshida; Taisei Kikuchi; Ichiro Nakagawa
        Microbiology resource announcements, 21 Nov. 2019, Peer-reviewed
      • Rab35 GTPase recruits NPD52 to autophagy targets
        Minowa-Nozawa A; Nozawa T; Okamoto-Furuta K; Kohda H; Nakagawa I
        EMBO Journal, Aug. 2017, Peer-reviewed
      • Prevalent emm types and superantigen gene patterns of group A Streptococcus in Thailand
        Paveenkittiporn W; Nozawa, T; Dejsirilert S; Nakagawa I; Hamada S
        Epidemiology and Infection, Mar. 2016, Peer-reviewed
      • Rab Proteins in Autophagy: Streptococcus Model
        Nozawa T; Nakagawa I
        Autophagy, Infection, and the Immune Response, Feb. 2015, Peer-reviewed
      • Development of a Two-Step Multiplex PCR Assay for Typing of Capsular Polysaccharide Synthesis Gene Clusters of Streptococcus suis
        Okura M; lachance C; Osaki M; Sekizaki T; Maruyama F; Nozawa T; Nakagawa I; Hamada S; Rossignol C; Gottschalk M; Takamatsu D
        Journal of Clinical Microbiology, May 2014, Peer-reviewed

      Misc.

      • ゲノム解析から明らかとなったStreptococcus suisにおける曖昧な種の境界及び進化の鍵となるスポット
        大倉正稔; 野澤孝志; 渡辺孝康; 中川一路; 高松大輔; 大崎慎人; 関崎勉; 浜田茂幸; 丸山史人
        日本細菌学雑誌, 2015
      • TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy.
        Takashi Nozawa; Shunsuke Sano; Atsuko Minowa-Nozawa; Hirotaka Toh; Shintaro Nakajima; Kazunori Murase; Chihiro Aikawa; Ichiro Nakagawa
        Nature communications, 07 Feb. 2020
        Access this misc :
      • Group A Streptococcus NAD-Glycohydrolase Inhibits Caveolin 1-Mediated Internalization Into Human Epithelial Cells.
        Hirotaka Toh; Ching-Yu Lin; Shintaro Nakajima; Chihiro Aikawa; Takashi Nozawa; Ichiro Nakagawa
        Frontiers in cellular and infection microbiology, 2019
      • CRISPR-プロファージ相互作用解析から見出されたA群レンサ球菌のゲノム進化機構
        山田俊介; 柴崎真樹; 渡辺孝康; 相川知宏; 野澤孝志; 丸山史人; 中川一路
        日本細菌学雑誌, 2015
      • P25-42 CRISPRを保有するバクテリオファージの系統学的普遍性(ポスター発表)
        渡辺 孝康; 野澤 孝志; 丸山 史人; 中川 一路
        日本微生物生態学会講演要旨集, 2014
      • 8-Nitro-cGMP: an endogenous regulator of antibacterial autophagy
        Ito Chiaki; Saito Yohei; Nozawa Takashi; Fujii Shigemoto; Hashimoto Ryota; Sawa Tomohiro; Akaike Takaaki; Nakagawa Ichiro; Hirokazu Arimoto
        Symposium on the Chemistry of Natural Products, symposium papers, 2014
      • The specific behavior of intracellular Streptococcus progenies undergone the autophagic degradation is associated with bacterial streptolysin O and host small G proteins Rab5 and Rab7.
        Sakurai A; Maruyama F; Funao J; Nozawa T; Aikawa C; Okahashi N; Shintani S; Hamada S; Ooshima T; Nakagawa I
        J Biol Chem

      Presentations

      • TBC1D9を介したカルシウムシグナリングはTBK1依存性ゼノファジーを制御する
        野澤 孝志
        第92回日本細菌学会総会, 23 Apr. 2019
      • 選択的オートファジーを制御するRab GTPaseネットワーク
        野澤 孝志
        第26回母子医療センターシンポジウム, 06 Feb. 2019, Invited
      • 細胞内病原体センサーNLRP4はRho-アクチン制御を介してA群レンサ球菌に対するオートファジーを誘導する
        野澤 孝志
        第91回日本生化学会大会, 24 Sep. 2018
      • The Rab35 GTPase and TBK1 mark targets of autophagosomes by recruiting NDP52
        Takashi2 Nozawa
        The 17th Awaji International Forum on Infection and Immunity, 10 Sep. 2018

      Awards

      • Mar. 2018
        日本細菌学会, 黒屋奨学賞

      External funds: Kakenhi

      • Analysis of host control mechanism by novel function of Nga, a secreted toxin of group A Streptococcus
        Grant-in-Aid for Scientific Research (C)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        Takashi Nozawa
        From 01 Apr. 2021, To 31 Mar. 2024, Project Closed
        A群レンサ球菌;分泌毒素;ストレス応答;ストレス顆粒;NAD-glycohydrolase;Streptolysin O;ゴルジ体;Rab GTPase
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07023/
      • Functional analysis of Beclin 1 regulating different stages during bacterial infection
        Grant-in-Aid for Scientific Research (C)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        Chihiro Aikawa
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        A群レンサ球菌;Beclin 1;細胞侵入;AKT/PKB;ILK1;オートファジー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07537/
      • Elucidation of the Rab regulatory network that induces bacterial species-specific xenophagy
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        Ichiro Nakagawa
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        ゼノファジー;A群レンサ球菌;ユビキチン化;Fboxプロテイン;菌体表層糖鎖;GAC;ガレクチン;-A群レンサ球菌;SLO;Nga;ゴルジ体;黄色ブドウ球菌;RabGAP;RabGEF;オートファジー;上皮間接着;TBC1D9;細胞内カルシウム
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03471/
      • Conprehensive functional analyses of cell-wall proteins of Streptococcus suis
        Grant-in-Aid for Scientific Research (B)
        Basic Section 42020:Veterinary medical science-related
        Kyoto University;The University of Tokyo
        TSUTOMU SEKIZAKI
        From 01 Apr. 2019, To 31 Mar. 2023, Project Closed
        豚レンサ球菌;細胞壁タンパク質;遺伝子破壊株;網羅的機能解析;病原性;細胞壁結合蛋白質
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03126/
      • Xenophagy recognizes bacteria through carbohydrate-binding ubiquitin ligase complex
        Grant-in-Aid for Scientific Research (C)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        Takashi Nozawa
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        オートファジー;A群レンサ球菌;糖鎖;ゼノファジー;ガレクチン;GBP1;TBK1;TBC1D9;FBXO2;糖鎖認識
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07109/
      • Analysis of collaborative activities between the capsule-positive and capsule-negative Streptococcus suis in the induction of and escape from autophagy
        Grant-in-Aid for Challenging Exploratory Research
        The University of Tokyo
        Tsutomu Sekizaki
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        豚レンサ球菌;オートファジー;莢膜;心内膜炎;感染症;細胞障害性;細胞侵入性;細胞壁タンパク質;オードファジー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15037/
      • The role of Bcl-xL in the formation of the Beclin 1 complex and induction of autophagy during bacterial infection
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Chihiro Aikawa
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        オートファジー;Group A Streptococcus;Beclin 1;Bcl-xL;NLRX1;UVRAG;Beclin1複合体
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K08775/
      • Regulation of xenophagy aginst Group A Streptococcus
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        ICHIRO NAKAGAWA
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        A群レンサ球菌;オートファジー;Rab35;TDC1D10A;ゼノファジー;Rab30;フォスファチジルイノシトール4リン酸;細菌感染;ユビキチン化;Rabタンパク質;A群特異的糖鎖;ユビキチン;アダプター;糖鎖
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05188/
      • Visualization of bacteria-induced autophagy by live-imaging.
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        ICHIRO NAKAGAWA
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        A群レンサ球菌;オートファジー;イメージング;Rabタンパク質;ゼノファジー;膜形成
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15130/
      • Molecular mechanism of selective autophagy against bacterial pathogens
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Takashi Nozawa
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        オートファジー;Rab GTPase;オートファジーアダプター;RAB GTPase;A群レンサ球菌;Rabタンパク質
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462776/
      • Establishment of a new prediction medhods of epidemic strains in Group A Streptococcus by CRISPR typing.
        Grant-in-Aid for Scientific Research (B)
        Kyoto University;Tokyo Medical and Dental University
        ICHIRO NAKAGAWA
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        A群レンサ球菌;emmタイピング;CRIPSR;レンサ球菌;ゲノム;莢膜;CRISPR;ブタレンサ球;スペーサー解析;流行予測;国際研究者交流;タイ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25305013/
      • Analysis of Atg5 dependent and independent autophagy and induction mechanism of inflammation during bacterial infection.
        Grant-in-Aid for Scientific Research (B)
        Kyoto University;Tokyo Medical and Dental University
        ICHIRO NAKAGAWA
        From 01 Apr. 2013, To 31 Mar. 2016, Project Closed
        A群レンサ球菌;xenophagy;オートファジー;Rabタンパク質;炎症;Rab30;Rab9;Rab23;Rab17;認識分子;炎症誘導;Atg5
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293370/
      • Xenophagy membrane dynamics
        Grant-in-Aid for Young Scientists (B)
        Tokyo Medical and Dental University
        Takashi NOZAWA
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        オートファジー;A群レンサ球菌;Rabタンパク質;Rab GTPase
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790413/
      • A群レンサ球菌の金属輸送系を標的とした治療薬剤としての人工抗体の取得
        Grant-in-Aid for Scientific Research (C)
        Basic Section 49050:Bacteriology-related
        Obihiro University of Agriculture and Veterinary Medicine;Kyoto University
        相川 知宏
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        A群レンサ球菌;金属輸送体;MntE;CzcD;抗体治療薬
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07053/
      • Elucidation of Xenophagy Regulation by Bacterial Glycan Recognition
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        中川 一路
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        ゼノファジー;Ａ群レンサ球菌;自然免疫;糖鎖認識;A群レンサ球菌;ユビキチン;認識;GBP1;ガレクチン３;TBK1;細菌感染
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02868/
      • Elucidation of the mechanism of competition between different bacterial species via extracellular vesicles and its application to the development of new drug discovery technologies
        Grant-in-Aid for Scientific Research (C)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        村瀬 一典
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        細胞外小胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06528/
      • 多様な細菌感染に対するロバストネスを支えるゼノファジー機構の解明
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        野澤 孝志
        From 01 Apr. 2024, To 31 Mar. 2027, Granted
        A群レンサ球菌;ゼノファジー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02279/
      • Elucidation of Xenophagy Regulation by Bacterial Glycan Recognition
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49050:Bacteriology-related
        Kyoto University
        中川 一路
        From 01 Apr. 2022, To 31 Mar. 2025, Granted
        細菌感染;ゼノファジー;ユビキチン;Ａ群レンサ球菌;A群レンサ球菌;ESCRT;Rab41;SLO;VPS4;自然免疫;糖鎖認識;認識;GBP1;ガレクチン３;TBK1
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24130/
      • 細菌感染誘導性ストレス顆粒による第3のNRF2-KEAP1活性化経路の解明
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 49:Pathology, infection/immunology, and related fields
        Kyoto University
        野澤 孝志
        From 28 Jun. 2024, To 31 Mar. 2026, Granted
        ストレス顆粒;KEAP1;NRF2;A群レンサ球菌
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K22052/
      list
        Last Updated :2025/05/27

        Administration

        Faculty management (title, position)

        • From 01 Oct. 2022, To 30 Sep. 2024
          京都大学医学研究科・医学部動物実験委員会
        • From 01 Apr. 2015, To 31 Mar. 2017
          医学図書館図書連絡委員会
        • From 01 Nov. 2016, To 30 Sep. 2018
          動物実験委員会委員
        • From 01 Apr. 2017, To 31 Mar. 2018
          動物実験施設運営委員
        • From 01 Oct. 2020, To 30 Sep. 2022
          動物実験委員会委員

        ページ上部へ戻る