Yamashiro, Sawako(Graduate School of Biostudies, Division of Systemic Life Science) | Activity Database on Education and Research, Kyoto University

Yamashiro, Sawako

Graduate School of Biostudies, Division of Systemic Life Science Associate Professor

Last Updated :2025/05/22

Basic Information

Faculty

医学部

Email Address

Email Address
yamashiro.sawako.5ckyoto-u.ac.jp

Professional Memberships

From 2023, To Present
日本生物物理学会

American Society for Cell Biology

日本薬理学会

日本分子生物学会

日本細胞生物学会

Academic Degree

修士（理工学）(上智大学)

博士（学術）(東京大学)

ID,URL

J-Global ID
201401071141980214

researchmap URL

https://researchmap.jp/7000010388

Last Updated :2025/05/22

Research

Research Topics, Overview of the research

Research Topics
蛍光単分子イメージングによるアクチン依存的細胞内力の動態と役割の解明

Research Areas

Life sciences, Cell biology, アクチン細胞骨格、蛍光１分子顕微鏡、メカノバイオロジー

Papers

Actin Filament Pointed Ends: Assays for Regulation of Assembly and Disassembly by Tropomodulin and Tropomyosin
Sawako Yamashiro; Shashank Shekhar; Stefanie M Novak; Sudipta Biswas; Carol C Gregoril; Velia M Fowler
Cytoskeleton, Feb. 2025, Peer-reviewed, Lead author

Force transmission by retrograde actin flow-induced dynamic molecular stretching of Talin
Sawako Yamashiro; David M. Rutkowski; Kelli Ann Lynch; Ying Liu; Dimitrios Vavylonis; Naoki Watanabe
Nature Communications, 20 Dec. 2023, Peer-reviewed, Lead author, Corresponding author
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A mechanism with severing near barbed ends andannealing explains structure and dynamics of dendriticactin networks.
Danielle Holz; Aaron R Hall; Eiji Usukura; Sawako Yamashiro; Naoki Watanabe; Dimitrios Vavylonis
eLife, 07 Jun. 2022, Peer-reviewed
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Lamellipodium tip actin barbed ends serve as a force sensor.
Koseki K; Taniguchi D; Yamashiro S; Mizuno H; Vavylonis D; Watanabe N
Genes to cells : devoted to molecular & cellular mechanisms, Nov. 2019, Peer-reviewed

Quantitative high-precision imaging of myosin-dependent filamentous actin dynamics.
Yamashiro S; Watanabe N
Journal of muscle research and cell motility, Jul. 2019, Peer-reviewed, Invited, Lead author, Corresponding author

Convection-Induced Biased Distribution of Actin Probes in Live Cells.
Yamashiro S; Taniguchi D; Tanaka S; Kiuchi T; Vavylonis D; Watanabe N
Biophysical journal, Jan. 2019, Peer-reviewed, Lead author, Corresponding author

Mechanostress resistance involving formin homology proteins: G- and F-actin homeostasis-driven filament nucleation and helical polymerization-mediated actin polymer stabilization.
Watanabe N; Tohyama K; Yamashiro S
Biochemical and biophysical research communications, Nov. 2018, Peer-reviewed

Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin
Hiroaki Mizuno; Kotaro Tanaka; Sawako Yamashiro; Akihiro Narita; Naoki Watanabe
Proceedings of the National Academy of Sciences of the United States of America, 29 May 2018, Peer-reviewed
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Myosin-dependent actin stabilization as revealed by single-molecule imaging of actin turnover.
Yamashiro S; Tanaka S; McMillen LM; Taniguchi D; Vavylonis D; Watanabe N
Molecular biology of the cell, May 2018, Peer-reviewed, Lead author, Corresponding author

Cell protrusion and retraction driven by fluctuations in actin polymerization: A two-dimensional model
Gillian L. Ryan; Danielle Holz; Sawako Yamashiro; Daisuke Taniguchi; Naoki Watanabe; Dimitrios Vavylonis
CYTOSKELETON, Dec. 2017, Peer-reviewed

An Infrared Actin Probe for Deep-Cell Electroporation-Based Single-Molecule Speckle (eSiMS) Microscopy
Sawako Yamashiro; Naoki Watanabe
SENSORS, Jul. 2017, Peer-reviewed, Invited, Lead author, Corresponding author
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Overview of Single-Molecule Speckle (SiMS) Microscopy and Its Electroporation-Based Version with Efficient Labeling and Improved Spatiotemporal Resolution
Sawako Yamashiro; Naoki Watanabe
SENSORS, Jul. 2017, Peer-reviewed, Invited, Lead author, Corresponding author
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UNC-87 isoforms, Caenorhabditis elegans calponin-related proteins, interact with both actin and myosin and regulate actomyosin contractility
Kanako Ono; Takashi Obinata; Sawako Yamashiro; Zhongmei Liu; Shoichiro Ono
MOLECULAR BIOLOGY OF THE CELL, May 2015, Peer-reviewed

An easy-to-use single-molecule speckle microscopy enabling nanometer-scale flow and wide-range lifetime measurement of cellular actin filaments
Sawako Yamashiro; Hiroaki Mizuno; Naoki Watanabe
BIOPHYSICAL METHODS IN CELL BIOLOGY, 2015, Peer-reviewed, Invited, Lead author, Corresponding author
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A new link between the retrograde actin flow and focal adhesions
Sawako Yamashiro; Naoki Watanabe
JOURNAL OF BIOCHEMISTRY, Nov. 2014, Peer-reviewed, Invited, Lead author, Corresponding author

Functional Effects of Mutations in the Tropomyosin-Binding Sites of Tropomodulin1 and Tropomodulin3
Raymond A. Lewis; Sawako Yamashiro; David S. Gokhin; Velia M. Fowler
CYTOSKELETON, Jul. 2014, Peer-reviewed

New single-molecule speckle microscopy reveals modification of the retrograde actin flow by focal adhesions at nanometer scales
Sawako Yamashiro; Hiroaki Mizuno; Matthew B. Smith; Gillian L. Ryan; Tai Kiuchi; Dimitrios Vavylonis; Naoki Watanabe
MOLECULAR BIOLOGY OF THE CELL, Apr. 2014, Peer-reviewed, Lead author

Differential Actin-regulatory Activities of Tropomodulin1 and Tropomodulin3 with Diverse Tropomyosin and Actin Isoforms*
Sawako Yamashiro; David S. Gokhin; Zhenhua Sui; Sarah E. Bergeron; Peter A. Rubenstein; Velia M. Fowler
JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2014, Peer-reviewed, Lead author

Molecular viewing of actin polymerizing actions and beyond: combination analysis of single-molecule speckle microscopy with modeling, FRAP and s-FDAP (sequential fluorescence decay after photoactivation).
Watanabe N; Yamashiro S; Vavylonis D; Kiuchi T
Development, growth & differentiation, May 2013, Peer-reviewed, Invited

Tropomodulin Protects alpha-Catenin-Dependent Junctional-Actin Networks under Stress during Epithelial Morphogenesis
Elisabeth A. Cox-Paulson; Elise Walck-Shannon; Allison M. Lynch; Sawako Yamashiro; Ronen Zaidel-Bar; Celeste C. Eno; Shoichiro Ono; Jeff Hardin
CURRENT BIOLOGY, Aug. 2012, Peer-reviewed

Tropomodulins: Pointed-end capping proteins that regulate actin filament architecture in diverse cell types
Sawako Yamashiro; David S. Gokhin; Sumiko Kimura; Roberta B. Nowak; Velia M. Fowler
CYTOSKELETON, Jun. 2012, Peer-reviewed, Lead author

Total Synthesis and Biological Evaluation of Monorhizopodin and 16-epi-Monorhizopodin
K. C. Nicolaou; Xuefeng Jiang; Peter J. Lindsay-Scott; Andrei Corbu; Sawako Yamashiro; Andrea Bacconi; Velia M. Fowler
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

Mammalian Tropomodulins Nucleate Actin Polymerization via Their Actin Monomer Binding and Filament Pointed End-capping Activities
Sawako Yamashiro; Kaye D. Speicher; David W. Speicher; Velia M. Fowler
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2010, Peer-reviewed, Lead author, Corresponding author

Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C-elegans
Sawako Yamashiro; Elisabeth A. Cox; David L. Baillie; Jeff D. Hardin; Shoichiro Ono
JOURNAL OF CELL SCIENCE, Dec. 2008, Peer-reviewed, Lead author

Caenorhabditis elegans gelsolin-like protein 1 is a novel actin filament-severing protein with four gelsolin-like repeats
Tuula Klaavuniemi; Sawako Yamashiro; Shoichiro Ono
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2008, Peer-reviewed

Essential role of ADF/cofilin for assembly of contractile actin networks in the C-elegans somatic gonad
Kanako Ono; Sawako Yamashiro; Shoichiro Ono
JOURNAL OF CELL SCIENCE, Aug. 2008, Peer-reviewed

UNC-87, a calponin-related protein in C. elegans, antagonizes ADF/cofilin-mediated actin filament dynamics
Sawako Yamashiro; Mario Gimona; Shoichiro Ono
JOURNAL OF CELL SCIENCE, Sep. 2007, Peer-reviewed, Lead author

IQGAP2 is required for the cadherin-mediated cell-to-cell adhesion in Xenopus laevis embryos
Sawako Yamashiro; Hiroshi Abe; Issei Mabuchi
DEVELOPMENTAL BIOLOGY, Aug. 2007, Peer-reviewed, Lead author

Enhancement of actin-depolymerizing factor/cofilin-dependent actin disassembly by actin-interacting protein 1 is required for organized actin filament assembly in the Caenorhabditis elegans body wall muscle
K Mohri; K Ono; R Yu; S Yamashiro; S Ono
MOLECULAR BIOLOGY OF THE CELL, May 2006, Peer-reviewed

The two Caenorhabditis elegans actin-depolymerizing factor/cofilin proteins differently enhance actin filament severing and depolymerization
S Yamashiro; K Mohri; S Ono
BIOCHEMISTRY, Nov. 2005, Peer-reviewed, Lead author

Localization of two IQGAPs in cultured cells and early embryos of Xenopus laevis
S Yamashiro; T Noguchi; Mabuchi, I
CELL MOTILITY AND THE CYTOSKELETON, May 2003, Peer-reviewed, Lead author

Microtuble organization in Xenopus eggs during the first cleavage and its role in cytokinesis
M Takayama; T Noguchi; S Yamashiro; Mabuchi, I
CELL STRUCTURE AND FUNCTION, Aug. 2002

Misc.

Introducing our Associate Editorial Board: An interview with Sawako Yamashiro, Kyoto University, Kyoto, Japan
Paul Trevorrow; Sawako Yamashiro
Cytoskeleton, 12 Sep. 2024

Actomyosin contraction stabilizes actin filaments as revealed by live cell single-molecule imaging
山城佐和子; 渡邊直樹
BIO Clinica, Oct. 2022, Invited, Lead author

細胞内蛍光単分子イメージングによるミオシン張力依存的なアクチン線維安定化の証明
山城佐和子; 渡邊直樹
生体の科学, Jun. 2021, Invited, Lead author

アクチンネットワークを駆け巡る力学作用の分子可視化
渡邊直樹; 山城佐和子
生化学, Feb. 2020, Invited, Last author

蛍光単分子イメージングが解き明かすミオシン張力によるアクチン線維安定化
山城佐和子; 渡邊直樹
月刊メディカル・サイエンス・ダイジェスト, 30 Jun. 2019

生細胞内でのアクチンフィラメント配向の可視化
通山潔; 山城佐和子; 渡邊直樹
日本生化学会大会プログラム・講演要旨集, Sep. 2018

分子から個体まで神経系を見る分子の窓を通して覗いた細胞の構造としくみ
渡邊直樹; 木内泰; 山城佐和子
バイオイメージング, Aug. 2016

ナノスケール単分子スペックル解析により明らかにする細胞仮足が「つかみ取る」しくみ
山城佐和子; 山城佐和子; 田中聡一郎; 渡邊直樹; 渡邊直樹
日本細胞生物学会大会(Web), 2016

【細胞シグナル操作法】機能からみたシグナル操作法細胞の動態細胞骨格(アクチン系)
山城佐和子; 渡邊直樹
生体の科学, 15 Oct. 2015

【Molecular Imaging 2014 分子イメージングはどこまで進んだか】分子イメージングの最新動向光イメージングの最新動向細胞内蛍光単分子イメージングが解き明かす生命の動的なしくみ
渡邊直樹; 山城佐和子; 水野裕昭
INNERVISION, Jun. 2014

Update Review アクチン研究の最新動向構造から調節、恒常性、可視化、モデリングまで
山城佐和子; 圓岡真宏; 水野裕昭; 渡邊直樹
実験医学, Nov. 2012

フォルミンmDia1の螺旋回転を介したアクチン脱重合抵抗性
水野裕昭; 山城佐和子; 渡邊直樹
日本分子生物学会年会プログラム・要旨集(Web), 2012

Inhibition of ADF/cofilin binding to actin filaments by UNC-87, a C-elegans calponin-repeat protein
S Yamashiro; JH Woo; M Gimona; S Ono
MOLECULAR BIOLOGY OF THE CELL, Nov. 2004

Profilin contributes to cleavage furrow formation in Xenopus eggs
OKazuhiro Yamada; Sawako Yamashiro; Issei Mabuchi
CELL STRUCTURE AND FUNCTION, May 2004

Analysis of localization and function of two isoforms of Xenopus IQGAP in early embryos and cultured cells
S Yamashiro; T Noguchi; Mabuchi, I
MOLECULAR BIOLOGY OF THE CELL, Nov. 2002

The Gelsolin/Fragmin Family Protein Identified in the Higher Plant Mimosa pudica
YAMASHIRO Sawako; KAMEYAMA Kazuhisa; KANZAWA Nobuyuki; TAMIYA Toru; MABUCHI Issei; TSUCHIYA Takahide
Journal of Biochemistry, 01 Aug. 2001

Low Molecular-weight G-actin Binding Proteins Involved in the Regulation of Actin Assembly during Myofibrillogenesis
OBINATA Takashi; NAGAOKA-Yasuda Rie; ONO Shoichiro; KUSANO Kenichi; MOHRI Kurato; OHTAKA Yoshiharu; YAMASHIRO Sawako; OKADA Kyoko; ABE Hiroshi
Cell Structure and Function, Feb. 1997

Presentations

ずり応力が引き起こす細胞膜タンパク質勾配形成の高解像イメージング解析
山城佐和子
第47回日本分子生物学会年会シンポジウム「流動力研究の最前線」, 27 Nov. 2024

細胞内蛍光１分子可視化で捉えたTalinによる力伝達の仕組み
山城佐和子
第97回日本生化学会大会シンポジウム：膜臨界場を起点とする「しなやかさ生物学」の創成, 08 Nov. 2024, Invited

細胞内蛍光１分子イメージングの改良とメカノバイオロジーへの応用
山城佐和子
第2回研究者をつなぐ研究フォーラム〜ライフサイエンスの交差点〜, 22 Aug. 2024, Invited

Force transmission mechanism as revealed by live-cell single-molecule imaging
Sawako Yamashiro; Ying Liu; Naoki Watanabe
第76回日本細胞生物学会大会シンポジウム（新学術）バイオ物性と細胞運命決定, 19 Jul. 2024, Invited

Force transmission via retrograde actin flow-induced dynamic molecular stretching of Talin
Sawako Yamashiro
The 21st KU-NYU-TU International Joint Mini-symposium on Molecular and Cell Biology, 08 Jun. 2024, Invited

Mechanisms of flow force transmission as revealed by live-cell single-molecule imaging
Sawako Yamashiro; Naoki Watanabe
第46回日本分子生物学会年会シンポジウム「細胞突起の形成機構と新たな機能」, 07 Dec. 2023, Invited

Force transmission via dynamic stretching of Talin as revealed by quantitative live-cell single molecule imaging
Sawako Yamashiro; David M. Rutkowski; Ying Liu; Kelli Ann Lynch; Dimitrios Vavylonis; Naoki Watanabe
日本生物物理学会第61回年会シンポジウム「自発と応答の情報物理学」, 16 Nov. 2023, Invited

New insights into the retrograde actin flow associated motion of Talin visualized by single-molecule speckle microscopy
Sawako Yamashiro
The EMBO/COB Workshop Satellite Meeting "New Approaches for the Properties of Bio-materials", 28 Jul. 2023, Invited

Talinの elastic transient clutch による力伝達機構
山城佐和子
第75回日本細胞生物学会大会シンポジウム「メカノバイオロジー研究で迫る細胞-微小環境の相互作用」, 28 Jun. 2023

Force transmission via dynamic stretching of Talin as revealed by live-cell single-molecule imaging
Sawako Yamashiro; David M. Rutkowski; Kelli Ann Lynch; Ying Liu; Dimitrios Vavylonis; Naoki Watanabe
American Physical Society March Meeting, 06 Mar. 2023, Invited

蛍光単分子イメージングで明らかにする流動力伝達の仕組み
山城佐和子
定量生物学の会第十回年会, 16 Dec. 2022, Invited

細胞内蛍光単分子イメージングによるアクチン線維流動力伝達機構の解明
山城佐和子
第11回分子モーター討論会, 14 Nov. 2022, Invited

ずり応力が引き起こす細胞膜分子勾配形成の蛍光１分子イメージング解析
山城佐和子; 野村実里; 渡邊直樹
第７４回日本細胞生物学会大会, 30 Jun. 2022

Coupling between focal adhesion molecules and retrograde actin flow visualized by quantitative live-cell single-molecule imaging
山城佐和子; 劉穎; 渡邊直樹
第44回日本分子生物学会年会, 01 Dec. 2021

高精度単分子イメージングによるアクチン繊維流動ー接着斑連関の可視化解明
山城佐和子; 劉穎; 渡邊直樹
第73回日本細胞生物学会, 02 Jul. 2021

New insights into the retrograde F-actin flow-associated motions of focal adhesion molecules visualized by single-molecule speckle (SiMS) microscopy
Sawako Yamashiro
The 43rd Annual Meeting of the Molecular Biology Society of Japan, 04 Dec. 2020, Invited

単分子イメージングによるアクチン線維流動ー接着斑分子連結機構の可視化解明
山城佐和子; 劉穎; 渡邊直樹
第１９回日本蛋白質科学会・第71回日本細胞生物学会合同年次大会, 25 Jun. 2019

Myosin-dependent actin stabilization as revealed by single-molecule speckle (SiMS) analysis of actin turnover.
Sawako Yamashiro
The 16th International Membrane Research Forum, 20 Mar. 2019, Invited

Retrograde flow-induced biased distribution of actin probes in live cells.
山城佐和子
American Society for Cell Biology / EMBO 2018 meeting, 09 Dec. 2018

Books and Other Publications

ラング・デール薬理学
山城佐和子, Joint translation
丸善出版, Dec. 2018, Not refereed

生体の科学特集：細胞シグナル操作法、第66巻第5号
山城佐和子, Contributor, 細胞骨格（アクチン系）pp504-505
医学書院, 2015, Not refereed

実験医学第30巻第18号
山城佐和子, Contributor, アクチン研究の最新動向－構造から調節、恒常性、可視化、モデリングまで: Update Review pp2998-3005
羊土社, 2012, Not refereed

External funds: Kakenhi

High resolution fluorescence single-molecule imaging of ECM-cellular mechanical interactions
Grant-in-Aid for Transformative Research Areas (A)
Transformative Research Areas, Section (III)
Kyoto University
山城佐和子
From 01 Apr. 2024, To 31 Mar. 2026, Granted
蛍光１分子顕微鏡;細胞外マトリックス;アクチン細胞骨格;細胞接着;メカノバイオロジー
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24H01944/

Elucidation of the roles of flow forces by using single-molecule imaging in living cells
Grant-in-Aid for Transformative Research Areas (A)
Transformative Research Areas, Section (III)
Kyoto University
山城佐和子
From 01 Apr. 2023, To 31 Mar. 2025, Granted
メカノバイオロジー;蛍光１分子イメージング;定量生物学;流動;細胞接着
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23H04310/

高解像度分子可視化による力学的方向情報伝達機構の解明
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Complex systems
Kyoto University
山城佐和子
From 01 Apr. 2022, To 31 Mar. 2024, Granted
メカノバイオロジー;蛍光１分子イメージング;細胞膜分子;ずり応力;アクチン細胞骨格;shear stress;蛍光１分子顕微鏡;定量生物学;メカノセンス
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04843/

高精度単分子イメージングによるアクチンダイナミクス-接着斑連関の生理的意義の解明
Grant-in-Aid for Scientific Research (C)
Basic Section 44010:Cell biology-related
Kyoto University
山城佐和子
From 01 Apr. 2021, To 31 Mar. 2024, Granted
細胞内1分子顕微鏡;細胞接着;インテグリン;アクチン;接着斑;メカノバイオロジー;細胞内定量解析;シミュレーション;細胞内１分子顕微鏡;アクチン細胞骨格;細胞内蛍光１分子イメージング;アクチン線維流動
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06150/

Visualization of microenvironment sensing mechanism by fluorescence single-molecule imaging
Grant-in-Aid for Transformative Research Areas (A)
Transformative Research Areas, Section (III)
Kyoto University
山城佐和子
From 10 Sep. 2021, To 31 Mar. 2023, Project Closed
メカノバイオロジー;剪断応力;細胞膜タンパク質;細胞接着;蛍光１分子顕微鏡;定量生物学;微小環境;細胞膜;ずり応力;膜タンパク質;内皮細胞;蛍光１分子イメージング;アクチン細胞骨格
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H05780/

高解像度分子可視化による力学的情報メモリの定量的解析
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Complex systems
Kyoto University
山城佐和子
From 01 Apr. 2020, To 31 Mar. 2022, Project Closed
メカノバイオロジー;ずり応力;アクチン細胞骨格;蛍光１分子顕微鏡;数理モデル解析;細胞膜;接着分子;GPIアンカー型タンパク質;細胞内蛍光１分子イメージング;メカノセンシング;細胞膜タンパク質;受容体;１分子イメージング
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05531/

Quantitative high-precision live-cell single-molecule imaging of focal adhesion molecules
Grant-in-Aid for Scientific Research (C)
Basic Section 44010:Cell biology-related
Kyoto University
Sawako Yamashiro
From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
1分子イメージング;アクチン;細胞内流動;細胞接着;定量的イメージング;数理モデル;接着斑;細胞運動;細胞内蛍光１分子顕微鏡;定量ライブイメージング;数理モデル解析;ミオシン;一分子イメージング;ライブイメージング;アクチン細胞骨格;メカノセンサー分子
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06217/

The role of actomyosin contraction on actin filament stability revealed by using new easy-to-use Single-Molecule Speckle (eSiMS) microscopy.
Grant-in-Aid for Scientific Research (C)
Kyoto University
Yamashiro Sawako
From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
一分子イメーシング;定量的イメージング;メカノセンシング;アクチン;ミオシン;一分子イメージング;接着斑;細胞運動
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07045/

革新的イメージングによる上皮細胞間コミュニケーションの異常における力の役割
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Biological Sciences
Kyoto University
山城佐和子
From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
蛍光単分子イメージング;メカノセンシング;アクチン;接着斑;細胞外基質;顕微鏡技術;一分子イメージング;アクチン細胞骨格;上皮細胞;細胞接着
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26112702/

Quantitative analysis of the retrograde actin flow by a new single-molecule speckle microscopy
Grant-in-Aid for Young Scientists (B)
Tohoku University
Sawako YAMASHIRO
From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
単分子スペックル法;一分子イメージング;アクチン;細胞運動;計測生物学;国際情報交換
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24770056/

上皮細胞ラテラル領域におけるアクチン繊維流動”力”の機能解明
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Biological Sciences
Tohoku University
山城佐和子
From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
一分子イメージング;アクチン細胞骨格;細胞運動;細胞接着;国際情報交換（アメリカ）
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24112503/

High resolution fluorescence single-molecule imaging of ECM-cellular mechanical interactions
Grant-in-Aid for Transformative Research Areas (A)
Transformative Research Areas, Section (III)
Kyoto University
山城佐和子
From 01 Apr. 2024, To 31 Mar. 2026, Granted
蛍光１分子顕微鏡;細胞外マトリックス;アクチン細胞骨格;細胞接着;メカノバイオロジー
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24H01944/

Elucidation of the roles of flow forces by using single-molecule imaging in living cells
Grant-in-Aid for Transformative Research Areas (A)
Transformative Research Areas, Section (III)
Kyoto University
山城佐和子
From 01 Apr. 2023, To 31 Mar. 2025, Granted
メカノバイオロジー;蛍光１分子イメージング;定量生物学;流動;細胞接着;蛍光１分子顕微鏡;shear stress;アクチン細胞骨格
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23H04310/

高解像度分子可視化による力学的方向情報伝達機構の解明
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Complex systems
Kyoto University
山城佐和子
From 01 Apr. 2022, To 31 Mar. 2024, Project Closed
メカノバイオロジー;蛍光１分子顕微鏡;定量生物学;アクチン細胞骨格;細胞接着;シミュレーション解析;蛍光１分子イメージング;細胞膜分子;ずり応力;shear stress;メカノセンス
https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04843/

Elucidation of physiological significance of actin dynamics-focal adhesion linkage by single-molecule imaging
Grant-in-Aid for Scientific Research (C)
Basic Section 44010:Cell biology-related
Kyoto University
Sawako Yamashiro
From 01 Apr. 2021, To 31 Mar. 2024, Project Closed
細胞接着;アクチン細胞骨格;蛍光１分子顕微鏡;定量生物学;メカノバイオロジー;細胞内1分子顕微鏡;インテグリン;アクチン;接着斑;細胞内定量解析;シミュレーション;細胞内１分子顕微鏡;細胞内蛍光１分子イメージング;アクチン線維流動
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06150/

Last Updated :2025/05/22

Education

Teaching subject(s)

From 01 Apr. 2024, To 31 Mar. 2025
Global Frontier in Life Science B
1033, Fall, Graduate School of Biostudies, 1

From 01 Apr. 2024, To 31 Mar. 2025
Advanced Course in Immunology and Human Disorders
1031, Fall, Graduate School of Biostudies, 1

From 01 Apr. 2024, To 31 Mar. 2025
Advanced Experiments in Systemic Life Sciences
5013, Spring, Graduate School of Biostudies, 4

From 01 Apr. 2024, To 31 Mar. 2025
Advanced Experiments in Systemic Life Sciences
5013, Fall, Graduate School of Biostudies, 4

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar C
2008, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar C
2008, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar B
2007, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar D
2009, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar D
2009, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar B
2007, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar A
2006, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2024, To 31 Mar. 2025
Experimental Course and Seminar A
2006, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Introduction to Biology and Life Science
N484, Spring, Institute for Liberal Arts and Sciences, 2

From 01 Apr. 2023, To 31 Mar. 2024
Global Frontier in Life Science B
1033, Fall, Graduate School of Biostudies, 1

From 01 Apr. 2023, To 31 Mar. 2024
Advanced Course in Immunology and Human Disorders
1031, Spring, Graduate School of Biostudies, 1

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar D
2009, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar C
2008, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar C
2008, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar D
2009, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar A
2006, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar B
2007, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar B
2007, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Experimental Course and Seminar A
2006, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2023, To 31 Mar. 2024
Advanced Experiments in Systemic Life Sciences
5013, Spring, Graduate School of Biostudies, 4

From 01 Apr. 2023, To 31 Mar. 2024
Advanced Experiments in Systemic Life Sciences
5013, Fall, Graduate School of Biostudies, 4

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar D
2009, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Global Frontier in Life Science B
1033, Fall, Graduate School of Biostudies, 1

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar B
2007, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar D
2009, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Experiments in Systemic Life Sciences
5013, Fall, Graduate School of Biostudies, 4

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Course in Immunology and Human Disorders
1031, Spring, Graduate School of Biostudies, 1

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar C
2008, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar C
2008, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar A
2006, Fall, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar A
2006, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Experimental Course and Seminar B
2007, Spring, Graduate School of Biostudies, 5

From 01 Apr. 2022, To 31 Mar. 2023
Advanced Experiments in Systemic Life Sciences
5013, Spring, Graduate School of Biostudies, 4

From Apr. 2019, To Mar. 2020
Advanced Course in Immunology and Human Disorders
Spring, 生命科学研究科

From Apr. 2020, To Mar. 2021
Global Frontier in Life Science B
Fall, 生命科学研究科

From Apr. 2020, To Mar. 2021
Advanced Course in Immunology and Human Disorders
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Global Frontier in Life Science B
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Experimental Course and Seminar
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Advanced Experiments in Systemic Life Sciences
Spring, 生命科学研究科

From Apr. 2021, To Mar. 2022
Advanced Experiments in Systemic Life Sciences
Fall, 生命科学研究科

From Apr. 2021, To Mar. 2022
Advanced Course in Immunology and Human Disorders
Spring, 生命科学研究科

Student achievements: Awards

新学術領域「生命の情報物理学」第4回奨励賞
Ying Liu, 05 Mar. 2024

新学術領域「生命の情報物理学」第１回領域研究賞
野村実里, 新学術領域「情報物理学でひもとく生命の秩序と設計原理」, 15 Feb. 2022

Last Updated :2025/05/22

Administration

Faculty management (title, position)

From 01 Oct. 2022
人材育成企画室

From 01 Apr. 2023
ダイバーシティ推進委員会

From 01 Apr. 2023
広報委員会

From 01 Apr. 2022, To 31 Mar. 2023
情報発信・ホームページ委員会

From 01 Apr. 2019
よろず相談窓口委員会（ハラスメント相談窓口委員会）

From 01 Apr. 2021, To 31 Mar. 2023
男女共同参画推進アクションプラン推進委員会　委員

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