Basic Information

Academic Degree

• Ｐｈ．Ｄ．(Autonoma University of Madrid)

ID,URL

• J-Global ID

  201801016925414214

researchmap URL

• https://researchmap.jp/7000025197

Research

Research Interests

• Chromosome organization
• Chromatin
• Genomics
• DNA repair
• Cancer

Research Areas

• Life sciences, Molecular biology, chromatin
• Life sciences, Genomics, Chromosome organization
• Life sciences, Molecular biology, DNA repair

Papers

• Neuronal enhancers are hotspots for DNA single-strand break repair

  Wei Wu; Sarah E. Hill; William J. Nathan; Jacob Paiano; Elsa Callen; Dongpeng Wang; Kenta Shinoda; Niek van Wietmarschen; Jennifer M. Colón-Mercado; Dali Zong; Raffaella De Pace; Han-Yu Shih; Steve Coon; Maia Parsadanian; Raphael Pavani; Hana Hanzlikova; Solji Park; Seol Kyoung Jung; Peter J. McHugh; Andres Canela; Chongyi Chen; Rafael Casellas; Keith W. Caldecott; Michael E. Ward; André Nussenzweig

  Nature, 20 May 2021, Peer-reviewed

  
• Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

  Shar-yin N. Huang; Stephanie A. Michaels; Brianna B. Mitchell; Nadim Majdalani; Arnaud Vanden Broeck; Andres Canela; Yuk-Ching Tse-Dinh; Valerie Lamour; Yves Pommier

  Science Advances, 05 Mar. 2021, Peer-reviewed

  
• END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells

  Nancy Wong; Sam John; André Nussenzweig; Andres Canela

  Methods in Molecular Biology, 2021, Last author

  
• 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

  Elsa Callen; Dali Zong; Wei Wu; Nancy Wong; Andre Stanlie; Momoko Ishikawa; Raphael Pavani; Lavinia C. Dumitrache; Andrea K. Byrum; Carlos Mendez-Dorantes; Paula Martinez; Andres Canela; Yaakov Maman; Amanda Day; Michael J. Kruhlak; Maria A. Blasco; Jeremy M. Stark; Nima Mosammaparast; Peter J. McKinnon; André Nussenzweig

  Molecular Cell, Jan. 2020, Peer-reviewed

  
• Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire

  Kenta Shinoda; Yaakov Maman; Andres Canela; David G. Schatz; Ferenc Livak; André Nussenzweig

  Cell Reports, Dec. 2019, Peer-reviewed

  
• Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

  Canela A; Maman Y; Huang SN; Wutz G; Tang W; Zagnoli-Vieira G; Callen E; Wong N; Day A; Peters JM; Caldecott KW; Pommier Y; Nussenzweig A

  Molecular Cell, Jul. 2019, Peer-reviewed

  
• Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

  Tubbs A; Sridharan S; van Wietmarschen N; Maman Y; Callen E; Stanlie A; Wu W; Wu X; Day A; Wong N; Yin M; Canela A; Fu H; Redon C; Pruitt SC; Jaszczyszyn Y; Aladjem MI; Aplan PD; Hyrien O; Nussenzweig A

  Cell, Aug. 2018, Peer-reviewed

  
• The Energetics and Physiological Impact of Cohesin Extrusion.

  Vian L; Pękowska A; Rao SSP; Kieffer-Kwon KR; Jung S; Baranello L; Huang SC; El Khattabi L; Dose M; Pruett N; Sanborn AL; Canela A; Maman Y; Oksanen A; Resch W; Li X; Lee B; Kovalchuk AL; Tang Z; Nelson S; Di Pierro M; Cheng RR; Machol I; St Hilaire BG; Durand NC; Shamim MS; Stamenova EK; Onuchic JN; Ruan Y; Nussenzweig A; Levens D; Aiden EL; Casellas R

  Cell, May 2018, Peer-reviewed

  
• Genome Organization Drives Chromosome Fragility

  Andres Canela; Yaakov Maman; Seolkyoung Jung; Nancy Wong; Elsa Callen; Amanda Day; Kyong-Rim Kieffer-Kwon; Aleksandra Pekowska; Hongliang Zhang; Suhas S. P. Rao; Su-Chen Huang; Peter J. Mckinnon; Peter D. Aplan; Yves Pommier; Erez Lieberman Aiden; Rafael Casellas; Andre Nussenzweig

  CELL, Jul. 2017, Peer-reviewed

  
• DNA Breaks and End Resection Measured Genome-wide by End Sequencing

  Andres Canela; Sriram Sridharan; Nicholas Sciascia; Anthony Tubbs; Paul Meltzer; Barry P. Sleckman; Andre Nussenzweig

  MOLECULAR CELL, Sep. 2016, Peer-reviewed

  
• The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

  Ana Ortega-Molina; Isaac W. Boss; Andres Canela; Heng Pan; Yanwen Jiang; Chunying Zhao; Man Jiang; Deqing Hu; Xabier Agirre; Itamar Niesvizky; Ji-Eun Lee; Hua-Tang Chen; Daisuke Ennishi; David W. Scott; Anja Mottok; Christoffer Hother; Shichong Liu; Xing-Jun Cao; Wayne Tam; Rita Shaknovich; Benjamin A. Garcia; Randy D. Gascoyne; Kai Ge; Ali Shilatifard; Olivier Elemento; Andre Nussenzweig; Ari M. Melnick; Hans-Guido Wendel

  NATURE MEDICINE, Oct. 2015, Peer-reviewed

  
• Single-Cell Telomere-Length Quantification Couples Telomere Length to Meristem Activity and Stem Cell Development in Arabidopsis

  Mary-Paz Gonzalez-Garcia; Irina Pavelescu; Andres Canela; Xavier Sevillano; Katherine A. Leehy; Andrew D. L. Nelson; Marta Ibanes; Dorothy E. Shippen; Maria A. Blasco; Ana I. Cano-Delgado

  CELL REPORTS, May 2015, Peer-reviewed

  
• Collateral DNA Damage Produced by Genome-Editing Drones: Exception or Rule?

  Andres Canela; Andre Stanlie; Andre Nussenzweig

  MOLECULAR CELL, May 2015, Peer-reviewed

  
• DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

  Margarida A. Santos; Robert B. Faryabi; Aysegul V. Ergen; Amanda M. Day; Amy Malhowski; Andres Canela; Masahiro Onozawa; Ji-Eun Lee; Elsa Callen; Paula Gutierrez-Martinez; Hua-Tang Chen; Nancy Wong; Nadia Finkel; Aniruddha Deshpande; Susan Sharrow; Derrick J. Rossi; Keisuke Ito; Kai Ge; Peter D. Aplan; Scott A. Armstrong; Andre Nussenzweig

  NATURE, Oct. 2014, Peer-reviewed

  
• Accumulation of Cells With Short Telomeres Is Associated With Impaired Zinc Homeostasis and Inflammation in Old Hypertensive Participants

  Catia Cipriano; Silvia Tesei; Marco Malavolta; Robertina Giacconi; Elisa Muti; Laura Costarelli; Francesco Piacenza; Sara Pierpaoli; Roberta Galeazzi; Maria Blasco; Elsa Vera; Andres Canela; Fabrizia Lattanzio; Eugenio Mocchegiani

  JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, Jul. 2009, Peer-reviewed

  
• Epigenetic regulation of telomeres in human cancer

  E. Vera; A. Canela; M. F. Fraga; M. Esteller; M. A. Blasco

  ONCOGENE, Nov. 2008, Peer-reviewed

  
• Telomerase deficiency promotes oxidative stress by reducing catalase activity

  Gema Perez-Rivero; Maria P. Ruiz-Torres; Maria L. Diez-Marques; Andres Canela; Jose M. Lopez-Novoa; Manuel Rodriguez-Puyol; Maria A. Blasco; Diego Rodriguez-Puyol

  FREE RADICAL BIOLOGY AND MEDICINE, Nov. 2008, Peer-reviewed

  
• Centromere mitotic recombination in mammalian cells

  Isabel Jaco; Andres Canela; Elsa Vera; Maria A. Blasco

  JOURNAL OF CELL BIOLOGY, Jun. 2008, Peer-reviewed

  
• The longest telomeres: a general signature of adult stem cell compartments

  Ignacio Flores; Andres Canela; Elsa Vera; Agueda Tejera; George Cotsarelis; Maria A. Blasco

  GENES & DEVELOPMENT, Mar. 2008, Peer-reviewed

  
• High-throughput telomere length quantification by FISH and its application to human population studies

  Andres Canela; Elsa Vera; Peter Klatt; Maria A. Blasco

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2007, Peer-reviewed

  
• Telomere length analysis.

  Canela A; Klatt P; Blasco MA

  Methods in molecular biology (Clifton, N.J.), 2007, Peer-reviewed

  
• Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models

  S Franco; A Canela; P Klatt; MA Blasco

  CARCINOGENESIS, Sep. 2005, Peer-reviewed

  
• Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice

  A Canela; J Martin-Caballero; JM Flores; MA Blasco

  MOLECULAR AND CELLULAR BIOLOGY, May 2004, Peer-reviewed

  
• Massive telomere loss is an early event of DNA damage-induced apoptosis

  R Ramirez; J Carracedo; R Jimenez; A Canela; E Herrera; P Aljama; MA Blasco

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2003, Peer-reviewed

  

Misc.

• Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma

  Ana Ortega-Molina; Isaac W. Boss; Andres Canela; Heng Pan; Yanwen Jiang; Chunying Zhao; Man Jiang; Deqing Hu; Ji-Eun Lee; Hua-Tang Chen; Daisuke Ennishi; David W. Scott; Christoffer Hother; Shichong Liu; Xing-Jun Cao; Wayne Tam; Rita Shaknovich; Benjamin A. Garcia; Randy D. Gascoyne; Kai Ge; Ali Shilatifard; Olivier Elemento; Andre Nussenzweig; Ari M. Melnick; Hans-Guido Wendel

  CANCER RESEARCH, Jan. 2016

  

Industrial Property Rights

• 特許20090280485, 特願20090280485, Methods and Reagents for the Determination of Telomere Length in a Semi-Automatic Manner of Every Single Cell in a Immobilized Cell Population

  Andres Canela

  

External funds: Kakenhi

• Development of a methodology to map and quantify in the genome DNA single strand breaks.

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  Andres Canela

  From 30 Jul. 2020, To 31 Mar. 2022, Project Closed

  DNA一本鎖切断;トポイソメラーゼI;DNA single-strand breaks;Next-gen sequencing;Genome instability;Cancer;DNA repair

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21393/
• Regulation of Genome Stability in Medaka

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 63:Environmental analyses and evaluation and related fields

  Osaka University

  Takeshi Todo

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  ゲノム不安定性;ゲノム構造変異;発がん;DNA修復酵素;メダカ;DNA二重鎖切断;自然発がん;TLS DNAポリメラーゼ;大腸がん;ゲノム安定性;ゲノム変異解析;自然発癌;遺伝性高発癌変異;ヘテロ接合性喪失

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00631/
• Elucidation of mechanisms of regeneration of periodontal tissue by mathematical modelling

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 57:Oral science and related fields

  Osaka University

  Chiharu Fujihara

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  歯周組織;再生機構;数理モデル;歯周組織再生;遺伝子発現;再生効果

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22714/
• Role of DNA topology in gene expression.

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Canela Andres

  From 01 Apr. 2019, To 31 Mar. 2021, Project Closed

  DNA Topoisomerases;Transcription;DNA torsion;RNA polymerase II;Chromatin loop;DNA torsions;RNA polymerase 2

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H05261/
• Genome organization as a source of chromosomal instability in cancer.

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43050:Genome biology-related

  Kyoto University

  Andres Canela

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  TOPOISOMERASEII;DNA 二重鎖切断;染色体転座発かん;ゲノム安定性;発かん;染色体転座;TOPOISOMERASE2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03208/
• アストロサイト形質転換の分子機序解明と創薬標的の探索

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49010:Pathological biochemistry-related

  Kyoto University

  小林 亜希子

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  神経炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02830/
• アストロサイト形質転換の分子機序解明と創薬標的の探索

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49010:Pathological biochemistry-related

  Kyoto University

  小林 亜希子

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  神経炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24092/