基本情報

学位

• Ｐｈ．Ｄ．(Autonoma University of Madrid)

ID,URL

• J-Global ID

  201801016925414214

researchmap URL

• https://researchmap.jp/7000025197

研究

研究キーワード

• Chromosome organization
• Chromatin
• Genomics
• DNA repair
• Cancer

研究分野

• ライフサイエンス, 分子生物学, chromatin
• ライフサイエンス, ゲノム生物学, Chromosome organization
• ライフサイエンス, 分子生物学, DNA repair

論文

• Neuronal enhancers are hotspots for DNA single-strand break repair

  Wei Wu; Sarah E. Hill; William J. Nathan; Jacob Paiano; Elsa Callen; Dongpeng Wang; Kenta Shinoda; Niek van Wietmarschen; Jennifer M. Colón-Mercado; Dali Zong; Raffaella De Pace; Han-Yu Shih; Steve Coon; Maia Parsadanian; Raphael Pavani; Hana Hanzlikova; Solji Park; Seol Kyoung Jung; Peter J. McHugh; Andres Canela; Chongyi Chen; Rafael Casellas; Keith W. Caldecott; Michael E. Ward; André Nussenzweig

  Nature, 2021年05月20日, 査読有り

  
• Exonuclease VII repairs quinolone-induced damage by resolving DNA gyrase cleavage complexes

  Shar-yin N. Huang; Stephanie A. Michaels; Brianna B. Mitchell; Nadim Majdalani; Arnaud Vanden Broeck; Andres Canela; Yuk-Ching Tse-Dinh; Valerie Lamour; Yves Pommier

  Science Advances, 2021年03月05日, 査読有り

  
• END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells

  Nancy Wong; Sam John; André Nussenzweig; Andres Canela

  Methods in Molecular Biology, 2021年, 最終著者

  
• 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

  Elsa Callen; Dali Zong; Wei Wu; Nancy Wong; Andre Stanlie; Momoko Ishikawa; Raphael Pavani; Lavinia C. Dumitrache; Andrea K. Byrum; Carlos Mendez-Dorantes; Paula Martinez; Andres Canela; Yaakov Maman; Amanda Day; Michael J. Kruhlak; Maria A. Blasco; Jeremy M. Stark; Nima Mosammaparast; Peter J. McKinnon; André Nussenzweig

  Molecular Cell, 2020年01月, 査読有り

  
• Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire

  Kenta Shinoda; Yaakov Maman; Andres Canela; David G. Schatz; Ferenc Livak; André Nussenzweig

  Cell Reports, 2019年12月, 査読有り

  
• Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

  Canela A; Maman Y; Huang SN; Wutz G; Tang W; Zagnoli-Vieira G; Callen E; Wong N; Day A; Peters JM; Caldecott KW; Pommier Y; Nussenzweig A

  Molecular Cell, 2019年07月, 査読有り

  
• Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse.

  Tubbs A; Sridharan S; van Wietmarschen N; Maman Y; Callen E; Stanlie A; Wu W; Wu X; Day A; Wong N; Yin M; Canela A; Fu H; Redon C; Pruitt SC; Jaszczyszyn Y; Aladjem MI; Aplan PD; Hyrien O; Nussenzweig A

  Cell, 2018年08月, 査読有り

  
• The Energetics and Physiological Impact of Cohesin Extrusion.

  Vian L; Pękowska A; Rao SSP; Kieffer-Kwon KR; Jung S; Baranello L; Huang SC; El Khattabi L; Dose M; Pruett N; Sanborn AL; Canela A; Maman Y; Oksanen A; Resch W; Li X; Lee B; Kovalchuk AL; Tang Z; Nelson S; Di Pierro M; Cheng RR; Machol I; St Hilaire BG; Durand NC; Shamim MS; Stamenova EK; Onuchic JN; Ruan Y; Nussenzweig A; Levens D; Aiden EL; Casellas R

  Cell, 2018年05月, 査読有り

  
• Genome Organization Drives Chromosome Fragility

  Andres Canela; Yaakov Maman; Seolkyoung Jung; Nancy Wong; Elsa Callen; Amanda Day; Kyong-Rim Kieffer-Kwon; Aleksandra Pekowska; Hongliang Zhang; Suhas S. P. Rao; Su-Chen Huang; Peter J. Mckinnon; Peter D. Aplan; Yves Pommier; Erez Lieberman Aiden; Rafael Casellas; Andre Nussenzweig

  CELL, 2017年07月, 査読有り

  
• DNA Breaks and End Resection Measured Genome-wide by End Sequencing

  Andres Canela; Sriram Sridharan; Nicholas Sciascia; Anthony Tubbs; Paul Meltzer; Barry P. Sleckman; Andre Nussenzweig

  MOLECULAR CELL, 2016年09月, 査読有り

  
• The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

  Ana Ortega-Molina; Isaac W. Boss; Andres Canela; Heng Pan; Yanwen Jiang; Chunying Zhao; Man Jiang; Deqing Hu; Xabier Agirre; Itamar Niesvizky; Ji-Eun Lee; Hua-Tang Chen; Daisuke Ennishi; David W. Scott; Anja Mottok; Christoffer Hother; Shichong Liu; Xing-Jun Cao; Wayne Tam; Rita Shaknovich; Benjamin A. Garcia; Randy D. Gascoyne; Kai Ge; Ali Shilatifard; Olivier Elemento; Andre Nussenzweig; Ari M. Melnick; Hans-Guido Wendel

  NATURE MEDICINE, 2015年10月, 査読有り

  
• Single-Cell Telomere-Length Quantification Couples Telomere Length to Meristem Activity and Stem Cell Development in Arabidopsis

  Mary-Paz Gonzalez-Garcia; Irina Pavelescu; Andres Canela; Xavier Sevillano; Katherine A. Leehy; Andrew D. L. Nelson; Marta Ibanes; Dorothy E. Shippen; Maria A. Blasco; Ana I. Cano-Delgado

  CELL REPORTS, 2015年05月, 査読有り

  
• Collateral DNA Damage Produced by Genome-Editing Drones: Exception or Rule?

  Andres Canela; Andre Stanlie; Andre Nussenzweig

  MOLECULAR CELL, 2015年05月, 査読有り

  
• DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier

  Margarida A. Santos; Robert B. Faryabi; Aysegul V. Ergen; Amanda M. Day; Amy Malhowski; Andres Canela; Masahiro Onozawa; Ji-Eun Lee; Elsa Callen; Paula Gutierrez-Martinez; Hua-Tang Chen; Nancy Wong; Nadia Finkel; Aniruddha Deshpande; Susan Sharrow; Derrick J. Rossi; Keisuke Ito; Kai Ge; Peter D. Aplan; Scott A. Armstrong; Andre Nussenzweig

  NATURE, 2014年10月, 査読有り

  
• Accumulation of Cells With Short Telomeres Is Associated With Impaired Zinc Homeostasis and Inflammation in Old Hypertensive Participants

  Catia Cipriano; Silvia Tesei; Marco Malavolta; Robertina Giacconi; Elisa Muti; Laura Costarelli; Francesco Piacenza; Sara Pierpaoli; Roberta Galeazzi; Maria Blasco; Elsa Vera; Andres Canela; Fabrizia Lattanzio; Eugenio Mocchegiani

  JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2009年07月, 査読有り

  
• Epigenetic regulation of telomeres in human cancer

  E. Vera; A. Canela; M. F. Fraga; M. Esteller; M. A. Blasco

  ONCOGENE, 2008年11月, 査読有り

  
• Telomerase deficiency promotes oxidative stress by reducing catalase activity

  Gema Perez-Rivero; Maria P. Ruiz-Torres; Maria L. Diez-Marques; Andres Canela; Jose M. Lopez-Novoa; Manuel Rodriguez-Puyol; Maria A. Blasco; Diego Rodriguez-Puyol

  FREE RADICAL BIOLOGY AND MEDICINE, 2008年11月, 査読有り

  
• Centromere mitotic recombination in mammalian cells

  Isabel Jaco; Andres Canela; Elsa Vera; Maria A. Blasco

  JOURNAL OF CELL BIOLOGY, 2008年06月, 査読有り

  
• The longest telomeres: a general signature of adult stem cell compartments

  Ignacio Flores; Andres Canela; Elsa Vera; Agueda Tejera; George Cotsarelis; Maria A. Blasco

  GENES & DEVELOPMENT, 2008年03月, 査読有り

  
• High-throughput telomere length quantification by FISH and its application to human population studies

  Andres Canela; Elsa Vera; Peter Klatt; Maria A. Blasco

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007年03月, 査読有り

  
• Telomere length analysis.

  Canela A; Klatt P; Blasco MA

  Methods in molecular biology (Clifton, N.J.), 2007年, 査読有り

  
• Effectors of mammalian telomere dysfunction: a comparative transcriptome analysis using mouse models

  S Franco; A Canela; P Klatt; MA Blasco

  CARCINOGENESIS, 2005年09月, 査読有り

  
• Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice

  A Canela; J Martin-Caballero; JM Flores; MA Blasco

  MOLECULAR AND CELLULAR BIOLOGY, 2004年05月, 査読有り

  
• Massive telomere loss is an early event of DNA damage-induced apoptosis

  R Ramirez; J Carracedo; R Jimenez; A Canela; E Herrera; P Aljama; MA Blasco

  JOURNAL OF BIOLOGICAL CHEMISTRY, 2003年01月, 査読有り

  

MISC

• Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma

  Ana Ortega-Molina; Isaac W. Boss; Andres Canela; Heng Pan; Yanwen Jiang; Chunying Zhao; Man Jiang; Deqing Hu; Ji-Eun Lee; Hua-Tang Chen; Daisuke Ennishi; David W. Scott; Christoffer Hother; Shichong Liu; Xing-Jun Cao; Wayne Tam; Rita Shaknovich; Benjamin A. Garcia; Randy D. Gascoyne; Kai Ge; Ali Shilatifard; Olivier Elemento; Andre Nussenzweig; Ari M. Melnick; Hans-Guido Wendel

  CANCER RESEARCH, 2016年01月

  

産業財産権

• 特許20090280485, 特願20090280485, Methods and Reagents for the Determination of Telomere Length in a Semi-Automatic Manner of Every Single Cell in a Immobilized Cell Population

  CANELA RODRIGUEZ,Andres

  

外部資金：科学研究費補助金

• Development of a methodology to map and quantify in the genome DNA single strand breaks.

  挑戦的研究(萌芽)

  中区分43:分子レベルから細胞レベルの生物学およびその関連分野

  京都大学

  Canela Andres

  自 2020年07月30日, 至 2022年03月31日, 完了

  DNA一本鎖切断;トポイソメラーゼI;DNA single-strand breaks;Next-gen sequencing;Genome instability;Cancer;DNA repair

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21393/
• ゲノム安定性維持機構破綻による遺伝的不安定性のゲノムレベルでの解析

  基盤研究(A)

  中区分63:環境解析評価およびその関連分野

  大阪大学

  藤堂 剛

  自 2020年04月01日, 至 2023年03月31日, 完了

  ゲノム不安定性;ゲノム構造変異;発がん;DNA修復酵素;メダカ;DNA二重鎖切断;自然発がん;TLS DNAポリメラーゼ;大腸がん;ゲノム安定性;ゲノム変異解析;自然発癌;遺伝性高発癌変異;ヘテロ接合性喪失

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00631/
• 数理モデリングによる歯周組織再生メカニズムの解明と再生効果予測

  挑戦的研究(萌芽)

  中区分57:口腔科学およびその関連分野

  大阪大学

  藤原 千春

  自 2019年06月28日, 至 2021年03月31日, 完了

  歯周組織;再生機構;数理モデル;歯周組織再生;遺伝子発現;再生効果

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22714/
• Role of DNA topology in gene expression.

  新学術領域研究(研究領域提案型)

  生物系

  京都大学

  Canela Andres

  自 2019年04月01日, 至 2021年03月31日, 完了

  DNA Topoisomerases;Transcription;DNA torsion;RNA polymerase II;Chromatin loop;DNA torsions;RNA polymerase 2

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H05261/
• Genome organization as a source of chromosomal instability in cancer.

  基盤研究(B)

  小区分43050:ゲノム生物学関連

  京都大学

  Canela Andres

  自 2019年04月01日, 至 2022年03月31日, 完了

  TOPOISOMERASEII;DNA 二重鎖切断;染色体転座発かん;ゲノム安定性;発かん;染色体転座;TOPOISOMERASE2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03208/
• アストロサイト形質転換の分子機序解明と創薬標的の探索

  基盤研究(B)

  小区分49010:病態医化学関連

  京都大学

  小林 亜希子

  自 2022年04月01日, 至 2025年03月31日, 交付

  神経炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02830/
• アストロサイト形質転換の分子機序解明と創薬標的の探索

  基盤研究(B)

  小区分49010:病態医化学関連

  京都大学

  小林 亜希子

  自 2022年04月01日, 至 2025年03月31日, 交付

  神経炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24092/