Reverse translational research into the mechanisms of pathogenesis of tissue damage and cancer, as well as drug discovery for prevention and treatment.
Overview of the research
Reverse translational research focusing on the laryngeal vocal folds and inner ear cochlea is underway. First, basic experiments using mouse models of the pathology and human cell ines are used to clarify a part of mechanisms of the pathogenesis. Then, based on these findings, each result are verifid through clinical research using patient specimens and medical record information. Ultimately, we would like to contribute to healthcare by those obtaining knowledge useful for the prevention, diagnosis or drug treatment.
Research Interests
DDS・障害・再生・発生
Research Areas
Life sciences, Clinical pharmacy, Drug delivery system, cochlea, vocal fold, lung, thyroid, impairment, regeneration, development
Papers
Transcriptomic landscape of hyperthyroidism in mice overexpressing thyroid-Stimulating hormone.
The use of a MITO-Porter to deliver exogenous therapeutic RNA to a mitochondrial disease's cell with a A1555G mutation in the mitochondrial 12S rRNA gene results in an increase in mitochondrial respiratory activity
Tomoko Kita
Mitochondrion, 2020
N-acetyltransferase 2 genotype-related efficacy of Sulfasalazine in patients with rheumatoid arthritis
Tomoko Kita
Pharmaceutical Research, 2004
Different contribution of CYP2C19 in the in vitro metabolism of three proton pump inhibitors
Tomoko Kita
Biological and Pharmaceutical Bulletin, 2003
Effects of various storage conditions and alterations of antioxidant contents on chromatic aberration of hydroquinone ointment
Tomoko Kita
Biological and Pharmaceutical Bulletin, 2003
Impact of clarithromycin resistance and CYP2C19 genetic polymorphism on treatment efficacy of Helicobacter pylori infection with lansoprazole- or rabeprazole-based triple therapy in Japan
Tomoko Kita
European Journal of Gastroenterology & Hepatology, 2003
Effects of carvedilol on MDR1-mediated multidrug resistance: comparison with verapamil
Tomoko Kita
Cancer Science, 2003
Intradermal concentration of hydroquinone after application of hydroquinone ointments is higher than its cytotoxic concentration
Tomoko Kita
Biological and Pharmaceutical Bulletin, 2003
Pharmaceutical and clinical assessment of hydroquinone ointment prepared by extemporaneous nonsterile compounding
Tomoko Kita
Biological and Pharmaceutical Bulletin, 2002
Optimal dose of omeprazole for CYP2C19 extensive metabolizers in anti-Helicobacter pylori therapy:: Pharmacokinetic considerations
Tomoko Kita
Biological and Pharmaceutical Bulletin, 2002
N-acetyltransferase 2 genotype-related sulfapyridine acetylation and its adverse events
Tomoko Kita
Biological and Pharmaceutical Bulletin, 2002
MDR1-mediated interaction of digoxin with antiarrhythmic or antianginal drugs
Tomoko Kita
Biological and Pharmaceutical Bulletin, 2002
TOTAL-BODY AND HEPATIC-CLEARANCE IN RATS OF RECOMBINANT TISSUE-TYPE PLASMINOGEN-ACTIVATOR EXPRESSED IN MOUSE C127 AND CHINESE-HAMSTER OVARY CELLS
Tomoko Kita
Drug Metabolism and Disposition, 1992
Pharmacokinetics of monoclonal antibodies locally-applied into the middle ear of guinea pigs
Drug Metabolism and Pharmacokinetics, 09 Oct. 1997
Hearing preservation at low frequencies by insulin-like growth factor 1 in a guinea pig model of cochlear implantation
Tomoko Kita
Hearing Research, Oct. 2018, Peer-reviewed
FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia
Tomoko Kita
Proceedings of the National Academy of Sciences, Sep. 2018, Peer-reviewed
Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres
Elucidation of Inflammatory Mechanisms by Nrf2 Regulation in a Smoking Exposure Model and Development of Novel Therapy for Laryngeal Inflammatory Disease