Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 感染病態学, 教授
• Graduate School of Medicine, 医科学専攻 感染病態学, 教授
• Graduate School of Pharmaceutical Sciences, 薬科学専攻 分子ウイルス学, 教授

Professional Memberships

• 日本ウイルス学会
• 日本エイズ学会

Academic Degree

• 博士（医学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 熊本大学, 医学部医学科, 卒業

Research History

• From Apr. 2022, To Present

  Kyoto University, Institute for Liberal Arts and Sciences, Professor, Emeritus professor
• From Oct. 2014, To Mar. 2022

  Kyoto University, Institute for Frontier Life and Medical Sciences, Professor
• From Feb. 2004, To Sep. 2014

  Kyoto University, Institute for Virus Research, Professor
• From Apr. 1986, To Mar. 1989

  University of California Los Angeles, Division of Hematology-Oncology, Department of Medicine
• From Apr. 1999, To Jan. 2001

  Tohoku University, Graduate School of Medicine, Professor
• From 1994, To 1999

  Tokyo Medical and Dental University, Faculty of Medicine
• From 1992, To 1994

  Tokyo Medical and Dental University, Faculty of Medicine
• From 1990, To 1992

  Tokyo Medical and Dental University, Faculty of Medicine
• From 1989, To 1990

  Yamaguchi University, School of Medicine

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-3007-6642

• J-Global ID

  201801011387156941

Website(s) (URL(s))

• http://www2.infront.kyoto-u.ac.jp/Koyanagi_HP/

researchmap URL

• https://researchmap.jp/YKoya

Research

Research Topics, Overview of the research

• Research Topics

  Molecular biology of human pathogenic virus and development of its treatment

• Overview of the research

  I aim to reveal the molecular mechanism on pathogenesis of AIDS virus (HIV) and encephalitis- or cancer-associated herpes virus and to develop the treatment for the disease. Especially, I am concentrating how viral restriction factor acts against virus. To know the mechanism, we developed humanized mice (human hematopoetic stem-cell-transplanted mice) as an in vivo model for human pathogen.

Research Interests

• エイズウイルス
• Virus
• AIDS

Research Areas

• Life sciences, Immunology
• Life sciences, Molecular biology
• Life sciences, Virology

Papers

• Two-step evolution of HIV-1 budding system leading to pandemic in the human population.

  Yoriyuki Konno; Keiya Uriu; Takayuki Chikata; Toru Takada; Jun-Ichi Kurita; Mahoko Takahashi Ueda; Saiful Islam; Benjy Jek Yang Tan; Jumpei Ito; Hirofumi Aso; Ryuichi Kumata; Carolyn Williamson; Shingo Iwami; Masafumi Takiguchi; Yoshifumi Nishimura; Eiji Morita; Yorifumi Satou; So Nakagawa; Yoshio Koyanagi; Kei Sato

  Cell reports, 30 Jan. 2024

  
• Single-cell transcriptome analysis illuminating the characteristics of species-specific innate immune responses against viral infections.

  Hirofumi Aso; Jumpei Ito; Haruka Ozaki; Yukie Kashima; Yutaka Suzuki; Yoshio Koyanagi; Kei Sato

  GigaScience, 28 Dec. 2022

  
• Gorilla APOBEC3 restricts SIVcpz and influences lentiviral evolution in great ape cross-species transmissions

  Yusuke Nakano; Keisuke Yamamoto; Andrew Soper; Ryuichi Kumata; Hirofumi Aso; Naoko Misawa; Yoriyuki Konno; Izumi Kimura; Shumpei Nagaoka; Guillermo Juarez-Fern; ez; Jumpei Ito; Terumasa Ikeda; Yoshio Koyanagi; Reuben S Harris; Kei Sato

  04 Jul. 2018

  
• Resistance of SARS-CoV-2 variants to neutralization by antibodies induced in convalescent patients with COVID-19.

  Yu Kaku; Takeo Kuwata; Hasan Md Zahid; Takao Hashiguchi; Takeshi Noda; Noriko Kuramoto; Shashwata Biswas; Kaho Matsumoto; Mikiko Shimizu; Yoko Kawanami; Kazuya Shimura; Chiho Onishi; Yukiko Muramoto; Tateki Suzuki; Jiei Sasaki; Yoji Nagasaki; Rumi Minami; Chihiro Motozono; Mako Toyoda; Hiroshi Takahashi; Hiroto Kishi; Kazuhiko Fujii; Tsuneyuki Tatsuke; Terumasa Ikeda; Yosuke Maeda; Takamasa Ueno; Yoshio Koyanagi; Hajime Iwagoe; Shuzo Matsushita

  Cell reports, 13 Jul. 2021

  
• M-Sec facilitates intercellular transmission of HIV-1 through multiple mechanisms

  Sameh Lotfi; Hesham Nasser; Osamu Noyori; Masateru Hiyoshi; Hiroaki Takeuchi; Yoshio Koyanagi; Shinya Suzu

  Retrovirology, Dec. 2020, Peer-reviewed

  
• HIV and Host Factors in HIV Infection

  KOYANAGI Yoshio; MORIKAWA Yuko; SHIODA Tatsuo; TAKAORI KONDO Akifumi; MASUDA Takao; SPEARMAN Paul

  The Journal of AIDS Research, 20 May 2008

  
• An attempt of a pandemic planning by a local group for 2 years: The Miyagi Pandemic Influenza Study Group in Sendai, Japan

  Hidekazu Nishimura; Akira Suzuki; Oshi Watanabe; Kikuyoshi Yoshida; Kazuo Akiyama; Yoshio Koyanagi; Yasuhiko Hayakawa; Shigeki Moriizumi; Katumi Mizuta

  International Congress Series, 01 Jun. 2004, Peer-reviewed

  
• The Mechanism of HIV Infection and AIDS Development

  Aoki Jun; Koyanagi Yoshio

  Ikagaku Shinpojumu, 2002

  
• ケモカインレセプター

  鈴木 陽一; 小柳 義夫

  感染・炎症・免疫, Dec. 1998

  
• 遺伝子操作 遺伝子の導入 レトロウイルスベクター法

  鈴木 陽一; 小柳 義夫

  臨床免疫, May 1997

  
• The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis.

  Suzuki J; Kira J; Baba E; Nakamura M; Koyanagi Y; Nakamura T; Kawano Y; Yamasaki K; Sirabe S; Hatano N; Hayashi K; Yamamoto N; Kobayahsi T

  Journal of infectious diseases, May 1996, Peer-reviewed

  
• TAP-MS法によるインテグレース結合因子Huwe1の同定とその解析

  山元 誠司; 大川 克也; 小川 加那子; 増田 貴夫; 小柳 義夫; 鈴木 陽一

  日本エイズ学会誌, Nov. 2008

  
• PCRによる感染性HIV-DNAの構築とその問題点

  武内 寛明; 鈴木 陽一; 蝦名 博貴; 小柳 義夫

  日本エイズ学会誌, Nov. 2000

  
• ウイルス初感染直後に分離された感染性HIV-1の遺伝的性状

  武内 寛明; 鈴木 陽一; 山本 直樹; 小柳 義夫

  日本エイズ学会誌, Nov. 1999

  
• リアルタイムPCRを利用したHIV-1複製過程の解析

  佐藤 千尋; 鈴木 陽一; 小柳 義夫; 山本 直樹

  日本エイズ学会誌, Nov. 1999

  
• Mechanism of HIV-1 Entry

  KOYANAGI Yoshio

  The Journal of AIDS Research, 20 May 2001

  
• 6th Conference on Retroviruses and Opportunistic Infections Basic Medicine

  KOYANAGI Yoshio

  The Journal of AIDS Research, 1999

  
• Cell tropism of HIV

  KOYANAGI Yoshio

  Uirusu, 01 Dec. 1998

  
• HIV‐1 tracing method of systemic viremia in vivo using an artificially mutated virus pool

  Andrew Soper; Yoshio Koyanagi; Kei Sato

  Microbiology and Immunology, 07 Jan. 2021

  
• Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection.

  Ryuichi Kumata; Shoya Iwanami; Katrina B Mar; Yusuke Kakizoe; Naoko Misawa; Shinji Nakaoka; Yoshio Koyanagi; Alan S Perelson; John W Schoggins; Shingo Iwami; Kei Sato

  PLoS computational biology, Apr. 2022

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• Correction: HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation.

  Yusuke Nakano; Naoko Misawa; Guillermo Juarez-Fernandez; Miyu Moriwaki; Shinji Nakaoka; Takaaki Funo; Eri Yamada; Andrew Soper; Rokusuke Yoshikawa; Diako Ebrahimi; Yuuya Tachiki; Shingo Iwami; Reuben S Harris; Yoshio Koyanagi; Kei Sato

  PLoS pathogens, Sep. 2017

  
• Comprehensive Investigation on the Interplay between Feline APOBEC3Z3 Proteins and Feline Immunodeficiency Virus Vif Proteins.

  Yusuke Kosugi; Keiya Uriu; Narumi Suzuki; Keisuke Yamamoto; Shumpei Nagaoka; Izumi Kimura; Yoriyuki Konno; Hirofumi Aso; Brian J Willett; Tomoko Kobayashi; Yoshio Koyanagi; Mahoko Takahashi Ueda; Jumpei Ito; Kei Sato

  Journal of virology, 10 Jun. 2021

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• Animal Model of HIV-1 Infection. Hu-PBL-SCID Mouse.:-Hu-PBL-SCID Mouse-

  KOYANAGI Yoshio; TANAKA Yuetsu; ITO Mamoru; UEYAMA Yoshito

  Proceedings of The Japanese Society of Animal Models for Human Diseases, 1997

  
• CAGE-Seq Reveals that HIV-1 Latent Infection Does Not Trigger Unique Cellular Responses in a Jurkat T Cell Model

  Hiroyuki Matsui; Kotaro Shirakawa; Yoshinobu Konishi; Shigeki Hirabayashi; Anamaria Daniela Sarca; Hirofumi Fukuda; Ryosuke Nomura; Emani Stanford; Yoshihito Horisawa; Yasuhiro Kazuma; Tadahiko Matsumoto; Hiroyuki Yamazaki; Yasuhiro Murakawa; Emilie Battivelli; Eric Verdin; Yoshio Koyanagi; Akifumi Takaori-Kondo

  Journal of Virology, 27 Jan. 2021

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• Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression.

  Jumpei Ito; Izumi Kimura; Andrew Soper; Alexandre Coudray; Yoshio Koyanagi; Hirofumi Nakaoka; Ituro Inoue; Priscilla Turelli; Didier Trono; Kei Sato

  Science advances, Oct. 2020

  
• SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant.

  Yoriyuki Konno; Izumi Kimura; Keiya Uriu; Masaya Fukushi; Takashi Irie; Yoshio Koyanagi; Daniel Sauter; Robert J Gifford; So Nakagawa; Kei Sato

  Cell reports, 22 Sep. 2020

  
• A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans

  Yusuke Nakano; Keisuke Yamamoto; Mahoko Takahashi Ueda; Andrew Soper; Yoriyuki Konno; Izumi Kimura; Keiya Uriu; Ryuichi Kumata; Hirofumi Aso; Naoko Misawa; Shumpei Nagaoka; Soma Shimizu; Keito Mitsumune; Yusuke Kosugi; Guillermo Juarez-Fernandez; Jumpei Ito; So Nakagawa; Terumasa Ikeda; Yoshio Koyanagi; Reuben S. Harris; Kei Sato

  PLOS Pathogens, 10 Sep. 2020

  
• Quantifying the antiviral effect of APOBEC3 on HIV-1 infection in humanized mouse model

  Tatsuya Kurusu; Kwang Su Kim; Yoshiki Koizumi; Shinji Nakaoka; Keisuke Ejima; Naoko Misawa; Yoshio Koyanagi; Kei Sato; Shingo Iwami

  Journal of Theoretical Biology, Aug. 2020, Peer-reviewed

  
• Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In Vivo.

  Hirofumi Aso; Shumpei Nagaoka; Eiryo Kawakami; Jumpei Ito; Saiful Islam; Benjy Jek Yang Tan; Shinji Nakaoka; Koichi Ashizaki; Katsuyuki Shiroguchi; Yutaka Suzuki; Yorifumi Satou; Yoshio Koyanagi; Kei Sato

  Cell reports, 14 Jul. 2020, Peer-reviewed

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• N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation.

  Yamasoba, D; Sato, K; Ichinose, T; Imamura, T; Koepke, L; Joas, S; Reith, E; Hotter, D; Misawa, N; Akaki, K; Uehata, T; Mino, T; Miyamoto, S; Noda, T; Yamashita, A; Standley, D.M; Kirchhoff, F; Sauter, D; Koyanagi, Y; Takeuchi, O

  Nature Microbiology, May 2019, Peer-reviewed

  
• Comparative Description of the Expression Profile of Interferon-Stimulated Genes in Multiple Cell Lineages Targeted by HIV-1 Infection.

  Hirofumi Aso; Jumpei Ito; Yoshio Koyanagi; Kei Sato

  Frontiers in microbiology, 2019, Peer-reviewed

  
• インターフェロンのインパクト MALT1によるN4BP1の分解は潜伏感染HIV-1の再活性化を促進する

  山岨 大智; 佐藤 佳; 小柳 義夫; 竹内 理

  日本エイズ学会誌, Nov. 2018

  
• A naturally occurring feline APOBEC3 variant that loses anti-lentiviral activity by lacking two amino acid residues.

  Yoriyuki Konno; Shumpei Nagaoka; Izumi Kimura; Mahoko Takahashi Ueda; Ryuichi Kumata; Jumpei Ito; So Nakagawa; Tomoko Kobayashi; Yoshio Koyanagi; Kei Sato

  The Journal of general virology, May 2018, Peer-reviewed

  
• Author Correction: Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.

  Yorifumi Satou; Hiroo Katsuya; Asami Fukuda; Naoko Misawa; Jumpei Ito; Yoshikazu Uchiyama; Paola Miyazato; Saiful Islam; Ariberto Fassati; Anat Melamed; Charles R M Bangham; Yoshio Koyanagi; Kei Sato

  Scientific reports, 25 Apr. 2018, Peer-reviewed

  
• New World feline APOBEC3 potently controls inter-genus lentiviral transmission

  Yoriyuki Konno; Shumpei Nagaoka; Izumi Kimura; Keisuke Yamamoto; Yumiko Kagawa; Ryuichi Kumata; Hirofumi Aso; Mahoko Takahashi Ueda; So Nakagawa; Tomoko Kobayashi; Yoshio Koyanagi; Kei Sato

  Retrovirology, 10 Apr. 2018, Peer-reviewed

  
• Experimental adaptive evolution of simian immunodeficiency virus SIVcpz to pandemic human immunodeficiency virus type 1 by using a humanized mouse model

  Kei Sato; Naoko Misawa; Junko S. Takeuchi; Tomoko Kobayashi; Taisuke Izumi; Hirofumi Aso; Shumpei Nagaoka; Keisuke Yamamoto; Izumi Kimura; Yoriyuki Konno; Yusuke Nakano; Yoshio Koyanagi

  Journal of Virology, 01 Feb. 2018, Peer-reviewed

  
• Different effects of two mutations on the infectivity of Ebola virus glycoprotein in nine mammalian species

  Yohei Kurosaki; Mahoko Takahashi Ueda; Yusuke Nakano; Jiro Yasuda; Yoshio Koyanagi; Kei Sato; So Nakagawa

  Journal of General Virology, 01 Feb. 2018, Peer-reviewed

  
• Type I interferon responses by HIV-1 infection: Association with disease progression and control

  Andrew Soper; Izumi Kimura; Shumpei Nagaoka; Yoriyuki Konno; Keisuke Yamamoto; Yoshio Koyanagi; Kei Sato

  Frontiers in Immunology, 15 Jan. 2018, Peer-reviewed

  
• Human-Specific Adaptations in Vpu Conferring Anti-tetherin Activity Are Critical for Efficient Early HIV-1 Replication In Vivo

  Eri Yamada; Shinji Nakaoka; Lukas Klein; Elisabeth Reith; Simon Langer; Kristina Hopfensperger; Shingo Iwami; Gideon Schreiber; Frank Kirchhoff; Yoshio Koyanagi; Daniel Sauter; Kei Sato

  Cell Host and Microbe, 10 Jan. 2018, Peer-reviewed

  
• Broad-spectrum antiviral agents: secreted phospholipase A(2) targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane

  Ming Chen; Chie Aoki-Utsubo; Masanori Kameoka; Lin Deng; Yutaka Terada; Wataru Kamitani; Kei Sato; Yoshio Koyanagi; Makoto Hijikata; Keiko Shindo; Takeshi Noda; Michinori Kohara; Hak Hotta

  SCIENTIFIC REPORTS, Nov. 2017, Peer-reviewed

  
• Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model.

  Yorifumi Satou; Hiroo Katsuya; Asami Fukuda; Naoko Misawa; Jumpei Ito; Yoshikazu Uchiyama; Paola Miyazato; Saiful Islam; Ariberto Fassati; Anat Melamed; Charles R M Bangham; Yoshio Koyanagi; Kei Sato

  Scientific reports, 31 Jul. 2017, Peer-reviewed

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• Feline Immunodeficiency Virus Evolutionarily Acquires Two Proteins, Vif and Protease, Capable of Antagonizing Feline APOBEC3

  Rokusuke Yoshikawa; Junko S. Takeuchi; Eri Yamada; Yusuke Nakano; Naoko Misawa; Yuichi Kimura; Fengrong Ren; Takayuki Miyazawa; Yoshio Koyanagi; Kei Sato

  JOURNAL OF VIROLOGY, Jun. 2017, Peer-reviewed

  
• A conflict of interest: the evolutionary arms race between mammalian APOBEC3 and lentiviral Vif

  Yusuke Nakano; Hirofumi Aso; Andrew Soper; Eri Yamada; Miyu Moriwaki; Guillermo Juarez-Fernandez; Yoshio Koyanagi; Kei Sato

  RETROVIROLOGY, May 2017, Peer-reviewed

  
• HIV-1 competition experiments in humanized mice show that APOBEC3H imposes selective pressure and promotes virus adaptation

  Yusuke Nakano; Naoko Misawa; Guillermo Juarez-Fernandez; Miyu Moriwaki; Shinji Nakaoka; Takaaki Funo; Eri Yamada; Andrew Soper; Rokusuke Yoshikawa; Diako Ebrahimi; Yuuya Tachiki; Shingo Iwami; Reuben S. Harris; Yoshio Koyanagi; Kei Sato

  PLOS PATHOGENS, May 2017, Peer-reviewed

  
• Various plus unique: Viral protein U as a plurifunctional protein for HIV-1 replication

  Andrew Soper; Guillermo Juarez-Fernandez; Hirofumi Aso; Miyu Moriwaki; Eri Yamada; Yusuke Nakano; Yoshio Koyanagi; Kei Sato

  EXPERIMENTAL BIOLOGY AND MEDICINE, Apr. 2017, Peer-reviewed

  
• Functional mutations in spike glycoprotein of Zaire ebolavirus associated with an increase in infection efficiency

  Mahoko Takahashi Ueda; Yohei Kurosaki; Taisuke Izumi; Yusuke Nakano; Olamide K. Oloniniyi; Jiro Yasuda; Yoshio Koyanagi; Kei Sato; So Nakagawa

  Genes to Cells, 01 Feb. 2017, Peer-reviewed

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• APOBEC3 proteins can copackage and comutate HIV-1 genomes

  Belete A. Desimmie; Ryan C. Burdick; Taisuke Izumi; Hibiki Doi; Wei Shao; W. Gregory Alvord; Kei Sato; Yoshio Koyanagi; Sara Jones; Eleanor Wilson; Shawn Hill; Frank Maldarelli; Wei-Shau Hu; Vinay K. Pathak

  NUCLEIC ACIDS RESEARCH, Sep. 2016, Peer-reviewed

  
• A naturally occurring bovine APOBEC3 confers resistance to bovine lentiviruses: implication for the co-evolution of bovids and their lentiviruses

  Eri Yamada; Rokusuke Yoshikawa; Yusuke Nakano; Naoko Misawa; Tomoko Kobayashi; Fengrong Ren; Taisuke Izumi; Takayuki Miyazawa; Yoshio Koyanagi; Kei Sato

  SCIENTIFIC REPORTS, Sep. 2016, Peer-reviewed

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• Association of lymph-node antigens with lower Gag-specific central-memory and higher Env-specific effector-memory CD8(+) T-cell frequencies in a macaque AIDS model

  Hiroshi Ishii; Saori Matsuoka; Takushi Nomura; Midori Nakamura; Teiichiro Shiino; Yuko Sato; Naoko Iwata-Yoshikawa; Hideki Hasegawa; Kazuta Mizuta; Hiromi Sakawaki; Tomoyuki Miura; Yoshio Koyanagi; Taeko K. Naruse; Akinori Kimura; Tetsuro Matano

  SCIENTIFIC REPORTS, Jul. 2016, Peer-reviewed

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• Anti-HIV-1 potency of the CRISPR/Cas9 system insufficient to fully inhibit viral replication

  Shuhei Ueda; Hirotaka Ebina; Yuka Kanemura; Naoko Misawa; Yoshio Koyanagi

  MICROBIOLOGY AND IMMUNOLOGY, Jul. 2016, Peer-reviewed

  
• Small ruminant lentiviral Vif proteins commonly utilize cyclophilin A, an evolutionarily and structurally conserved protein, to degrade ovine and caprine APOBEC3 proteins

  Rokusuke Yoshikawa; Taisuke Izumi; Yusuke Nakano; Eri Yamada; Miyu Moriwaki; Naoko Misawa; Fengrong Ren; Tomoko Kobayashi; Yoshio Koyanagi; Kei Sato

  MICROBIOLOGY AND IMMUNOLOGY, Jun. 2016, Peer-reviewed

  
• Species-specific differences in the ability of feline lentiviral Vif to degrade feline APOBEC3 proteins

  Rokusuke Yoshikawa; Yusuke Nakano; Eri Yamada; Taisuke Izumi; Naoko Misawa; Yoshio Koyanagi; Kei Sato

  MICROBIOLOGY AND IMMUNOLOGY, Apr. 2016, Peer-reviewed

  
• Quantifying the effect of Vpu on the promotion of HIV-1 replication in the humanized mouse model

  Hiroki Ikeda; Shinji Nakaoka; Rob J. de Boer; Satoru Morita; Naoko Misawa; Yoshio Koyanagi; Kazuyuki Aihara; Kei Sato; Shingo Iwami

  RETROVIROLOGY, Apr. 2016, Peer-reviewed

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• Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication

  Youichi Suzuki; Wei-Xin Chin; Qi'En Han; Koji Ichiyama; Ching Hua Lee; Zhi Wen Eyo; Hirotaka Ebina; Hirotaka Takahashi; Chikako Takahashi; Beng Hui Tan; Takayuki Hishiki; Kenji Ohba; Toshifumi Matsuyama; Yoshio Koyanagi; Yee-Joo Tan; Tatsuya Sawasaki; Justin Jang Hann Chu; Subhash G. Vasudevan; Kouichi Sano; Naoki Yamamoto

  PLOS PATHOGENS, Jan. 2016, Peer-reviewed

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• A Naturally Occurring Domestic Cat APOBEC3 Variant Confers Resistance to Feline Immunodeficiency Virus Infection

  Rokusuke Yoshikawa; Taisuke Izumi; Eri Yamada; Yusuke Nakano; Naoko Misawa; Fengrong Ren; Michael A. Carpenter; Terumasa Ikeda; Carsten Muenk; Reuben S. Harris; Takayuki Miyazawa; Yoshio Koyanagi; Kei Sato

  JOURNAL OF VIROLOGY, Jan. 2016, Peer-reviewed

  
• Perspectives of Genome-Editing Technologies for HIV Therapy

  Hirotaka Ebina; Peter Gee; Yoshio Koyanagi

  CURRENT HIV RESEARCH, 2016, Peer-reviewed

  
• [Interplay between HIV-1 and APOBEC].

  Sato K; Koyanagi Y

  Seikagaku. The Journal of Japanese Biochemical Society, 2016, Peer-reviewed

  
• Coevolutionary dynamics between tribe Cercopithecini tetherins and their lentiviruses

  Junko S. Takeuchi; Fengrong Ren; Rokusuke Yoshikawa; Eri Yamada; Yusuke Nakano; Tomoko Kobayashi; Kenta Matsuda; Taisuke Izumi; Naoko Misawa; Yuta Shintaku; Katherine S. Wetzel; Ronald G. Collman; Hiroshi Tanaka; Vanessa M. Hirsch; Yoshio Koyanagi; Kei Sato

  SCIENTIFIC REPORTS, Nov. 2015, Peer-reviewed

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• Cell-to-cell infection by HIV contributes over half of virus infection

  Shingo Iwami; Junko S. Takeuchi; Shinji Nakaoka; Fabrizio Mammano; Francois Clavel; Hisashi Inaba; Tomoko Kobayashi; Naoko Misawa; Kazuyuki Aihara; Yoshio Koyanagi; Kei Sato

  ELIFE, Oct. 2015, Peer-reviewed

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• Experimental evaluation of the zoonotic infection potency of simian retrovirus type 4 using humanized mouse model

  Kei Sato; Tomoko Kobayashi; Naoko Misawa; Rokusuke Yoshikawa; Junko S. Takeuchi; Tomoyuki Miura; Munehiro Okamoto; Jun-ichirou Yasunaga; Masao Matsuoka; Mamoru Ito; Takayuki Miyazawa; Yoshio Koyanagi

  SCIENTIFIC REPORTS, Sep. 2015, Peer-reviewed

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• Down-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz

  Yusuke Nakano; Kenta Matsuda; Rokusuke Yoshikawa; Eri Yamada; Naoko Misawa; Vanessa M. Hirsch; Yoshio Koyanagi; Kei Sato

  JOURNAL OF GENERAL VIROLOGY, Sep. 2015, Peer-reviewed

  
• Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin

  Shingo Iwami; Kei Sato; Satoru Morita; Hisashi Inaba; Tomoko Kobayashi; Junko S. Takeuchi; Yuichi Kimura; Naoko Misawa; Fengrong Ren; Yoh Iwasa; Kazuyuki Aihara; Yoshio Koyanagi

  SCIENTIFIC REPORTS, Jul. 2015, Peer-reviewed

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• Vif determines the requirement for CBF-f3 in APOBEC3 degradation

  Rokusuke Yoshikawa; Junko S. Takeuchi; Eri Yamada; Yusuke Nakano; Fengrong Ren; Hiroshi Tanaka; Carsten Muenk; Reuben S. Harris; Takayuki Miyazawa; Yoshio Koyanagi; Kei Sato

  JOURNAL OF GENERAL VIROLOGY, Apr. 2015, Peer-reviewed

  
• Impacts of Humanized Mouse Models on the Investigation of HIV-1 Infection: Illuminating the Roles of Viral Accessory Proteins in Vivo

  Eri Yamada; Rokusuke Yoshikawa; Yusuke Nakano; Naoko Misawa; Yoshio Koyanagi; Kei Sato

  VIRUSES-BASEL, Mar. 2015, Peer-reviewed

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• A High Excision Potential of TALENs for Integrated DNA of HIV-Based Lentiviral Vector

  Hirotaka Ebina; Yuka Kanemura; Naoko Misawa; Tetsushi Sakuma; Tomoko Kobayashi; Takashi Yamamoto; Yoshio Koyanagi

  PLOS ONE, Mar. 2015, Peer-reviewed

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• Effect of eclipse phase on quantifying viral dynamics of acute HIV-1 infection in humanized mouse model

  Hiroki Ikeda; Shinji Nakaoka; Kei Sato; Naoko Misawa; Yoshio Koyanagi; Shingo Iwami

  Nonlinear Theory and Its Applications, IEICE, 2015

  
• Phosphorylation of Herpes Simplex Virus 1 dUTPase Regulates Viral Virulence and Genome Integrity by Compensating for Low Cellular dUTPase Activity in the Central Nervous System

  Akihisa Kato; Jun Arii; Yoshio Koyanagi; Yasushi Kawaguchi

  JOURNAL OF VIROLOGY, Jan. 2015, Peer-reviewed

  
• APOBEC3D and APOBEC3F Potently Promote HIV-1 Diversification and Evolution in Humanized Mouse Model

  Kei Sato; Junko S. Takeuchi; Naoko Misawa; Taisuke Izumi; Tomoko Kobayashi; Yuichi Kimura; Shingo Iwami; Akifumi Takaori-Kondo; Wei-Shau Hu; Kazuyuki Aihara; Mamoru Ito; Dong Sung An; Vinay K. Pathak; Yoshio Koyanagi

  PLOS PATHOGENS, Oct. 2014, Peer-reviewed

  
• Characterization of red-capped mangabey tetherin: implication for the co-evolution of primates and their lentiviruses

  Tomoko Kobayashi; Junko S. Takeuchi; Fengrong Ren; Kenta Matsuda; Kei Sato; Yuichi Kimura; Naoko Misawa; Rokusuke Yoshikawa; Yusuke Nakano; Eri Yamada; Hiroshi Tanaka; Vanessa M. Hirsch; Yoshio Koyanagi

  SCIENTIFIC REPORTS, Jul. 2014, Peer-reviewed

  
• Improving the estimation of the death rate of infected cells from time course data during the acute phase of virus infections: application to acute HIV-1 infection in a humanized mouse model

  Hiroki Ikeda; Rob J. de Boer; Kei Sato; Satoru Morita; Naoko Misawa; Yoshio Koyanagi; Kazuyuki Aihara; Shingo Iwami

  THEORETICAL BIOLOGY AND MEDICAL MODELLING, May 2014, Peer-reviewed

  
• Quantification of Deaminase Activity-Dependent and -Independent Restriction of HIV-1 Replication Mediated by APOBEC3F and APOBEC3G through Experimental-Mathematical Investigation

  Tomoko Kobayashi; Yoshiki Koizumi; Junko S. Takeuchi; Naoko Misawa; Yuichi Kimura; Satoru Morita; Kazuyuki Aihara; Yoshio Koyanagi; Shingo Iwami; Kei Sato

  JOURNAL OF VIROLOGY, May 2014, Peer-reviewed

  
• EFdA, a Reverse Transcriptase Inhibitor, Potently Blocks HIV-1 Ex Vivo Infection of Langerhans Cells within Epithelium

  Takamitsu Matsuzawa; Tatsuyoshi Kawamura; Youichi Ogawa; Kenji Maeda; Hirotomo Nakata; Kohji Moriishi; Yoshio Koyanagi; Hiroyuki Gatanaga; Shinji Shimada; Hiroaki Mitsuya

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2014, Peer-reviewed

  
• Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk

  Mayumi Imahashi; Taisuke Izumi; Dai Watanabe; Junji Imamura; Kazuhiro Matsuoka; Hirotaka Ode; Takashi Masaoka; Kei Sato; Noriyo Kaneko; Seiichi Ichikawa; Yoshio Koyanagi; Akifumi Takaori-Kondo; Makoto Utsumi; Yoshiyuki Yokomaku; Takuma Shirasaka; Wataru Sugiura; Yasumasa Iwatani; Tomoki Naoe

  PLOS ONE, Mar. 2014, Peer-reviewed

  
• CKIP-1 is an intrinsic negative regulator of T-cell activation through an interaction with CARMA1

  Takashi Sakamoto; Masayuki Kobayashi; Kohei Tada; Masanobu Shinohara; Katsuhiro Io; Kayoko Nagata; Fumie Iwai; Yoko Takiuchi; Yasuyuki Arai; Kouhei Yamashita; Keisuke Shindo; Norimitsu Kadowaki; Yoshio Koyanagi; Akifumi Takaori-Kondo

  PLoS ONE, 17 Jan. 2014, Peer-reviewed

  
• HIV-1のウイルス学

  佐藤佳; 小柳義夫

  HIV感染症とAIDS（最新医学 別冊）, 2014

  
• HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4(+) T Cells In Vivo

  Kei Sato; Naoko Misawa; Shingo Iwami; Yorifumi Satou; Masao Matsuoka; Yukihito Ishizaka; Mamoru Ito; Kazuyuki Aihara; Dong Sung An; Yoshio Koyanagi

  PLOS PATHOGENS, Dec. 2013, Peer-reviewed

  
• Oral Administration of the CCR5 Inhibitor, Maraviroc, Blocks HIV Ex Vivo Infection of Langerhans Cells within the Epithelium

  Takamitsu Matsuzawa; Tatsuyoshi Kawamura; Youichi Ogawa; Masaaki Takahashi; Rui Aoki; Kohji Moriishi; Yoshio Koyanagi; Hiroyuki Gatanaga; Andrew Blauvelt; Shinji Shimada

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Dec. 2013, Peer-reviewed

  
• Functional antagonism of Rhesus Macaque and Chimpanzee BST-2 by HIV-1 Vpu Is mediated by cytoplasmic domain interactions

  Takeshi Yoshida; Yoshio Koyanagi; Klaus Strebel

  Journal of Virology, Dec. 2013, Peer-reviewed

  
• Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus

  Hirotaka Ebina; Naoko Misawa; Yuka Kanemura; Yoshio Koyanagi

  SCIENTIFIC REPORTS, Aug. 2013, Peer-reviewed

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• Host Factor SAMHD1 Restricts DNA Viruses in Non-Dividing Myeloid Cells

  Joseph A. Hollenbaugh; Peter Gee; Jonathon Baker; Michele B. Daly; Sarah M. Amie; Jessica Tate; Natsumi Kasai; Yuka Kanemura; Dong-Hyun Kim; Brian M. Ward; Yoshio Koyanagi; Baek Kim

  PLoS Pathogens, Jun. 2013, Peer-reviewed

  
• A Novel Protective MHC-I Haplotype Not Associated with Dominant Gag-Specific CD8(+) T-Cell Responses in SIVmac239 Infection of Burmese Rhesus Macaques

  Naofumi Takahashi; Takushi Nomura; Yusuke Takahara; Hiroyuki Yamamoto; Teiichiro Shiino; Akiko Takeda; Makoto Inoue; Akihiro Iida; Hiroto Hara; Tsugumine Shu; Mamoru Hasegawa; Hiromi Sakawaki; Tomoyuki Miura; Tatsuhiko Igarashi; Yoshio Koyanagi; Taeko K. Naruse; Akinori Kimura; Tetsuro Matano

  PLOS ONE, Jan. 2013, Peer-reviewed

  
• Quantification of the Dynamics of Enterovirus 71 Infection by Experimental-Mathematical Investigation

  Mitsuko Fukuhara; Shingo Iwami; Kei Sato; Yorihiro Nishimura; Hiroyuki Shimizu; Kazuyuki Aihara; Yoshio Koyanagi

  JOURNAL OF VIROLOGY, Jan. 2013, Peer-reviewed

  
• Antimicrobial Peptide LL-37 Produced by HSV-2-Infected Keratinocytes Enhances HIV Infection of Langerhans Cells

  Youichi Ogawa; Tatsuyoshi Kawamura; Takamitsu Matsuzawa; Rui Aoki; Peter Gee; Atsuya Yamashita; Kohji Moriishi; Kenshi Yamasaki; Yoshio Koyanagi; Andrew Blauvelt; Shinji Shimada

  CELL HOST & MICROBE, Jan. 2013, Peer-reviewed

  
• The Hematopoietic Cell-Specific Rho GTPase Inhibitor ARHGDIB/D4GDI Limits HIV Type 1 Replication

  Tadashi Watanabe; Emiko Urano; Kosuke Miyauchi; Reiko Ichikawa; Makiko Hamatake; Naoko Misawa; Kei Sato; Hirotaka Ebina; Yoshio Koyanagi; Jun Komano

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Aug. 2012, Peer-reviewed

  
• "Mathematical Model of Disease" Innovation of Human Specific Disease Research Using Humanized Mouse: Complemented Research Between Applied Mathematics and Experimental Medicine

  岩見真吾; 岩見真吾; 佐藤佳; 小柳義夫

  応用数理, Jun. 2012, Peer-reviewed

  
• Integrase-independent HIV-1 infection is damage and produces a viral reservoir

  Hirotaka Ebina; Yuka Kanemura; Yasutsugu Suzuki; Kozue Urata; Naoko Misawa; Yoshio Koyanagi

  VIROLOGY, May 2012, Peer-reviewed

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• Vpu Augments the Initial Burst Phase of HIV-1 Propagation and Downregulates BST2 and CD4 in Humanized Mice

  Kei Sato; Naoko Misawa; Mitsuko Fukuhara; Shingo Iwami; Dong Sung An; Mamoru Ito; Yoshio Koyanagi

  JOURNAL OF VIROLOGY, May 2012, Peer-reviewed

  
• Identifying viral parameters from in vitro cell cultures

  Shingo Iwami; Kei Sato; Rob J. De Boer; Kazuyuki Aihara; Tomoyuki Miura; Yoshio Koyanagi

  FRONTIERS IN MICROBIOLOGY, 2012, Peer-reviewed

  
• Vpu and BST2: still not there yet?

  Kei Sato; Peter Gee; Yoshio Koyanagi

  FRONTIERS IN MICROBIOLOGY, 2012, Peer-reviewed

  
• Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mouse model

  佐藤 佳; 小柳 義夫

  血液内科, Dec. 2011, Invited

  
• HTLV Research 30th Year

  KOYANAGI Yoshio

  Uirusu, Dec. 2011, Invited

  
• APOBEC1-Mediated Editing and Attenuation of Herpes Simplex Virus 1 DNA Indicate That Neurons Have an Antiviral Role during Herpes Simplex Encephalitis

  Peter Gee; Yoshinori Ando; Hiroko Kitayama; Seiji P. Yamamoto; Yuka Kanemura; Hirotaka Ebina; Yasushi Kawaguchi; Yoshio Koyanagi

  JOURNAL OF VIROLOGY, Oct. 2011, Peer-reviewed

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• The mouse is out of the bag: insights and perspectives on HIV-1-infected humanized mouse models

  Kei Sato; Yoshio Koyanagi

  EXPERIMENTAL BIOLOGY AND MEDICINE, Aug. 2011, Peer-reviewed

  
• A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice

  Kei Sato; Naoko Misawa; Chuanyi Nie; Yorifumi Satou; Dai Iwakiri; Masao Matsuoka; Rei Takahashi; Kiyotaka Kuzushima; Mamoru Ito; Kenzo Takada; Yoshio Koyanagi

  BLOOD, May 2011, Peer-reviewed

  
• Huwel, a novel cellular interactor of Gag-Pol through integrase binding, negatively influences HIV-1 infectivity

  Seiji P. Yamamoto; Katsuya Okawa; Takashi Nakano; Kouichi Sano; Kanako Ogawa; Takao Masuda; Yuko Morikawa; Yoshio Koyanagi; Youichi Suzuki

  MICROBES AND INFECTION, Apr. 2011, Peer-reviewed

  
• Lineage analysis of newly generated neurons in organotypic culture of rat hippocampus

  Jun Yokose; Toru Ishizuka; Takeshi Yoshida; Jun Aoki; Yoshio Koyanagi; Hiromu Yawo

  NEUROSCIENCE RESEARCH, Mar. 2011, Peer-reviewed

  
• Identification of Amino Acids in the Human Tetherin Transmembrane Domain Responsible for HIV-1 Vpu Interaction and Susceptibility

  Tomoko Kobayashi; Hirotaka Ode; Takeshi Yoshida; Kei Sato; Peter Gee; Seiji P. Yamamoto; Hirotaka Ebina; Klaus Strebel; Hironori Sato; Yoshio Koyanagi

  JOURNAL OF VIROLOGY, Jan. 2011, Peer-reviewed

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• HIV-1 viral infectivity factor interacts with TP53 to induce G2 cell cycle arrest and positively regulate viral replication

  Taisuke Izumi; Katsuhiro Io; Masashi Matsui; Kotaro Shirakawa; Masanobu Shinohara; Yuya Nagai; Masahiro Kawahara; Masayuki Kobayashi; Hiroshi Kondoh; Naoko Misawa; Yoshio Koyanagi; Takashi Uchiyama; Akifumi Takaori-Kondo

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2010, Peer-reviewed

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• Remarkable Lethal G-to-A Mutations in vif-Proficient HIV-1 Provirus by Individual APOBEC3 Proteins in Humanized Mice

  Kei Sato; Taisuke Izumi; Naoko Misawa; Tomoko Kobayashi; Yoshiki Yamashita; Masahide Ohmichi; Mamoru Ito; Akifumi Takaori-Kondo; Yoshio Koyanagi

  JOURNAL OF VIROLOGY, Sep. 2010, Peer-reviewed

  
• Functional Disruption of the Moloney Murine Leukemia Virus Preintegration Complex by Vaccinia-related Kinases

  Yasutsugu Suzuki; Kanako Ogawa; Yoshio Koyanagi; Youichi Suzuki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2010, Peer-reviewed

  
• HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency

  Shigeki Hoshino; Mitsuru Konishi; Masako Mori; Mari Shimura; Chiaki Nishitani; Yoshio Kuroki; Yoshio Koyanagi; Shigeyuki Kano; Hiroyuki Itabe; Yukihito Ishizaka

  JOURNAL OF LEUKOCYTE BIOLOGY, Jun. 2010, Peer-reviewed

  
• Dynamics of memory and naive CD8(+) T lymphocytes in humanized NOD/SCID/IL-2R gamma(null) mice infected with CCR5-tropic HIV-1

  Kei Sato; Chuanyi Nie; Naoko Misawa; Yuetsu Tanaka; Mamoru Ito; Yoshio Koyanagi

  VACCINE, May 2010, Peer-reviewed

  
• T cell-based functional cDNA library screening identified SEC14-like 1a carboxy-terminal domain as a negative regulator of human immunodeficiency virus replication

  Emiko Urano; Reiko Ichikawa; Yuko Morikawa; Takeshi Yoshida; Yoshio Koyanagi; Jun Komano

  VACCINE, May 2010, Peer-reviewed

  
• Small intestine CD4(+) cell reduction and enteropathy in simian/human immunodeficiency virus KS661-infected rhesus macaques in the presence of low viral load

  Katsuhisa Inaba; Yoshinori Fukazawa; Kenta Matsuda; Ai Himeno; Megumi Matsuyama; Kentaro Ibuki; Yoshiharu Miura; Yoshio Koyanagi; Atsushi Nakajima; Richard S. Blumberg; Hidemi Takahashi; Masanori Hayami; Tatsuhiko Igarashi; Tomoyuki Miura

  JOURNAL OF GENERAL VIROLOGY, Mar. 2010, Peer-reviewed

  
• Mechanisms of HIV replication and anti-HIV drug action

  小柳 義夫; 渡部 匡史

  Japanese journal of clinical medicine, Mar. 2010, Invited

  
• HIV-1 のウイルス-宿主相互作用と新規治療薬の開発

  佐藤佳; 小柳義夫

  実験医学, 2010, Peer-reviewed

  
• N-linked glycan-dependent interaction of CD63 with CXCR4 at the Golgi apparatus induces downregulation of CXCR4

  Takeshi Yoshida; Hirotaka Ebina; Yoshio Koyanagi

  MICROBIOLOGY AND IMMUNOLOGY, Nov. 2009, Peer-reviewed

  
• Selective infection of CD4(+) effector memory T lymphocytes leads to preferential depletion of memory T lymphocytes in R5 HIV-1-infected humanized NOD/SCID/IL-2R gamma(null) mice

  Chuanyi Nie; Kei Sato; Naoko Misawa; Hiroko Kitayama; Hisanori Fujino; Hidefumi Hiramatsu; Toshio Heike; Tatsutoshi Nakahata; Yuetsu Tanaka; Mamoru Ito; Yoshio Koyanagi

  VIROLOGY, Nov. 2009, Peer-reviewed

  
• Efficient transduction of cytotoxic and anti-HIV-1 genes by a gene-regulatable lentiviral vector

  Yasuhiko Shinoda; Kuniko Hieda; Yoshio Koyanagi; Youichi Suzuki

  VIRUS GENES, Oct. 2009, Peer-reviewed

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• Comparative study on the effect of human BST-2/Tetherin on HIV-1 release in cells of various species

  Kei Sato; Seiji P. Yamamoto; Naoko Misawa; Takeshi Yoshida; Takayuki Miyazawa; Yoshio Koyanagi

  RETROVIROLOGY, Jun. 2009, Peer-reviewed

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• MDM2 is a novel E3 ligase for HIV-1 Vif

  Taisuke Izumi; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hiroaki Higashitsuji; Katsuhiko Itoh; Katsuhiro Io; Masashi Matsui; Kazuhiro Iwai; Hiroshi Kondoh; Toshihiro Sato; Mitsunori Tomonaga; Satoru Ikeda; Hirofumi Akari; Yoshio Koyanagi; Jun Fujita; Takashi Uchiyama

  RETROVIROLOGY, Jan. 2009, Peer-reviewed

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• Development of Human Graafian Follicles Following Transplantation of Human Ovarian Tissue into NOD/SCID/gamma cnull Mice

  Yukihiro Terada; Yumi Terunuma-Sato; Tomoko Kakoi-Yoshimoto; Hisataka Hasegawa; Tomohisa Ugajin; Yoshio Koyanagi; Mamoru Ito; Takashi Murakami; Hironobu Sasano; Nobuo Yaegashi; Kunihiro Okamura

  AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Dec. 2008, Peer-reviewed

  
• Identification of the P-TEFb complex-interacting domain of Brd4 as an inhibitor of HIV-1 replication by functional cDNA library screening in MT-4 cells

  Emiko Urano; Yumi Kariya; Yuko Futahashi; Reiko Ichikawa; Makiko Hamatake; Hidesuke Fukazawa; Yuko Morikawa; Takeshi Yoshida; Yoshio Koyanagi; Naoki Yamamoto; Jun Komano

  FEBS LETTERS, Dec. 2008, Peer-reviewed

  
• Primary target cells of herpes simplex virus type 1 in the hippocampus

  Yoshinori Ando; Hiroko Kitayama; Yasushi Kawaguchi; Yoshio Koyanagi

  MICROBES AND INFECTION, Nov. 2008, Peer-reviewed

  
• HIV Vpr is a neurotoxin

  小柳義夫

  医学のあゆみ, Sep. 2008, Invited

  
• A novel CD4-conjugated ultraviolet light-activated photocatalyst inactivates HIV-1 and SIV efficiently.

  Koushi Yamaguchi; Takahiro Sugiyama; Shinji Kato; Yoichi Kondo; Naohide Ageyama; Masaru Kanekiyo; Misao Iwata; Yoshio Koyanagi; Naoki Yamamoto; Mitsuo Honda

  Journal of medical virology, Aug. 2008, Peer-reviewed

  
• A CD63 mutant inhibits t-cell tropic human immunodeficiency virus type 1 entry by disrupting CXCR4 trafficking to the plasma membrane

  Takeshi Yoshida; Yuji Kawano; Kei Sato; Yoshinori Ando; Jun Aoki; Yoshiharu Miura; Jun Komano; Yuetsu Tanaka; Yoshio Koyanagi

  TRAFFIC, Apr. 2008, Peer-reviewed

  
• Significant virus replication in langerhans cells following application of HIV to abraded skin: Relevance to occupational transmission of HIV

  Tatsuyoshi Kawamura; Yoshio Koyanagi; Yuumi Nakamura; Youichi Ogawa; Atsuya Yamashita; Taku Iwamoto; Masahiko Ito; Andrew Blauvelt; Shinji Shimada

  JOURNAL OF IMMUNOLOGY, Mar. 2008, Peer-reviewed

  
• Human immunodeficiency virus type 1 Vpr inhibits axonal outgrowth through induction of mitochondrial dysfunction

  Hiroko Kitayama; Yoshiharu Miura; Yoshinori Ando; Shigeki Hoshino; Yukihito Ishizaka; Yoshio Koyanagi

  JOURNAL OF VIROLOGY, Mar. 2008, Peer-reviewed

  
• Human immunodeficiency virus type-1 vulnerates nascent neuronal cells

  Hiroko Kitayama; Yoshiharu Miura; Yoshinori Ando; Yoshio Koyanagi

  MICROBIOLOGY AND IMMUNOLOGY, Feb. 2008, Peer-reviewed

  
• Modulation of human immunodeficiency virus type 1 infectivity through incorporation of tetraspanin proteins

  Kei Sato; Jun Aoki; Naoko Misawa; Eriko Daikoku; Kouichi Sano; Yuetsu Tanaka; Yoshio Koyanagi

  JOURNAL OF VIROLOGY, Jan. 2008, Peer-reviewed

  
• 2008 年ノーベル医学・生理学 ② エイズウイルス発見のおもてうら

  小柳義夫

  細胞工 学, 2008, Invited

  
• Humanized mice for human retrovirus infection

  Y. Koyanagi; Y. Tanaka; M. Ito; N. Yamamoto

  HUMANIZED MICE, 2008

  
• HIV の細胞特異性

  小柳 義夫

  細胞, 2008, Peer-reviewed

  
• J. AIDS Res.

  小柳義夫; 森川裕子; 塩田; 高折晃史; 増田 夫; Paul Spearman

  日本 エイズ学会誌, 2008, Peer-reviewed

  
• ウイルスに感染するウイルス

  佐藤佳; 小柳義夫; Sputnik Sweetheart

  ウイルス( 日本ウ イルス学会 ), 2008, Invited

  
• エイズウイルス細胞とウイルスのせめぎあい

  鈴木陽一; 小柳義夫

  細胞工学, 2008, Invited

  
• インテグレーション阻害剤

  鈴木陽一; 小柳義夫

  KEYWORD 感染症, 2008, Peer-reviewed

  
• [Modulation of HIV replication by cellular factors].

  Suzuki Y; Koyanagi Y

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Aug. 2007, Peer-reviewed

  
• ウイルス感染に対する細胞応答・宿主応答とその制御 ＨＩＶ増殖を制御する宿主因子

  鈴木陽一; 小柳義夫

  蛋白質 核酸 酵素, Aug. 2007, Invited

  
• Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4

  Yuko Futahashi; Jun Komano; Emiko Urano; Toru Aoki; Makiko Hamatake; Kosuke Miyauchi; Takeshi Yoshida; Yoshio Koyanagi; Zene Matsuda; Naoki Yamamoto

  CANCER SCIENCE, Mar. 2007, Peer-reviewed

  
• Vpr in plasma of HIV type 1-positive patients is correlated with the HIV type 1 RNA titers

  Shigeki Hoshino; Binlian Sun; Mitsuru Konishi; Mari Shimura; Tatsuya Segawa; Yoshiaki Hagiwara; Yoshio Koyanagi; Aikichi Iwamoto; Jun-Ichi Mimaya; Hiroshi Terunuma; Shigeyuki Kano; Yukihito Ishizaka

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Mar. 2007, Peer-reviewed

  
• Autonomous proliferation of HTLV(-)CD4(+) T cell clones derived from human T cell leukemia virus type I (HTLV-1)-associated myelopathy patients

  Naoko Miyano-Kurosaki; Jun-ichi Kira; Jacob Samson Barnor; Naoyoshi Maeda; Naoko Misawa; Yuji Kawano; Yuetsu Tanaka; Naoki Yamamoto; Yoshio Koyanagi

  MICROBIOLOGY AND IMMUNOLOGY, 2007, Peer-reviewed

  
• De novo human T-cell leukemia virus type 1 infection of human lymphocytes in NOD-SCID, common gamma-chain knockout mice

  Paola Miyazato; Jun-ichirou Yasunaga; Yuko Taniguchi; Yoshio Koyanagi; Hiroaki Mitsuya; Masao Matsuoka

  JOURNAL OF VIROLOGY, Nov. 2006, Peer-reviewed

  
• Anti-V3 humanized antibody KD-247 effectively suppresses ex vivo generation of human immunodeficiency virus type 1 and affords sterile protection of monkeys against a heterologous simian/human immunodeficiency virus infection

  Y Eda; T Murakami; Y Ami; T Nakasone; M Takizawa; K Someya; M Kaizu; Y Izumi; N Yoshino; S Matsushita; H Higuchi; H Matsui; K Shinohara; H Takeuchi; Y Koyanagi; N Yamamoto; M Honda

  JOURNAL OF VIROLOGY, Jun. 2006, Peer-reviewed

  
• ＨＩＶ感染を抑制する宿主因子の探索

  小柳義夫; 芳田剛

  化学療法の領域, Jun. 2006, Invited

  
• De novo HTLV-I Infection of Human Lymphocytes in Nonobese Diabetic-SCID, Common γ-Chain Knocked-Out Mice.

  Miyazato P; Yasunaga J; Taniguchi Y; Koyanagi Y; Mitsuya H; Matsuoka M

  J. Virol. 80:10683-10691, 2006., 2006, Peer-reviewed

  
• HIV encephalopathy and neural stem cell virology

  Y. Miura; H. Kitayama; Y. Andou; Y. Koyanagi

  No to shinkei. Brain and nerve., 2006, Peer-reviewed

  
• HiV 感染症とAIDS 発症病理

  佐藤 佳; 小柳 義夫

  Virus Report, 2006, Invited

  
• Outline of HIV replication and its cellular factors: the track of an invader in the cell

  Viruses

  Uirusu, 22 Dec. 2005, Peer-reviewed, Invited

  
• Ku80 autoantigen as a cellular coreceptor for human parvovirus B19 infection

  Y Munakata; T Saito-Ito; K Kumura-Ishii; J Huang; T Kodera; T Ishii; Y Hirabayashi; Y Koyanagi; T Sasaki

  BLOOD, Nov. 2005, Peer-reviewed

  
• Solution RNA structures of the HIV-1 dimerization initiation site in the kissing-loop and extended-duplex dimers

  S Baba; K Takahashi; S Noguchi; H Takaku; Y Koyanagi; N Yamamoto; G Kawai

  JOURNAL OF BIOCHEMISTRY, Nov. 2005, Peer-reviewed

  
• ウイルスの感染と疾患発症機構 ２．ＨＩＶ感染を制御する細胞性因子

  小柳義夫

  実験医学, Oct. 2005, Invited

  
• Reproduction of menstrual changes in transplanted human endometrial tissue in immunodeficient mice

  R Matsuura-Sawada; T Murakami; Y Ozawa; H Nabeshima; J Akahira; Y Sato; Y Koyanagi; M Ito; Y Terada; K Okamura

  HUMAN REPRODUCTION, Jun. 2005, Peer-reviewed

  
• Death ligand-mediated apoptosis in HIV infection

  Y Miura; Y Koyanagi

  REVIEWS IN MEDICAL VIROLOGY, May 2005, Peer-reviewed

  
• Phylogenetic heterogeneity of new HTLV type 1 isolates from southern India in subgroup A

  S Ohkura; M Yamashita; T Ishida; PG Babu; Y Koyanagi; N Yamamoto; T Miura; M Hayami

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Apr. 2005, Peer-reviewed

  
• Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model

  H Nakata; K Maeda; T Miyakawa; S Shibayama; M Matsuo; Y Takaoka; M Ito; Y Koyanagi; H Mitsuya

  JOURNAL OF VIROLOGY, Feb. 2005, Peer-reviewed

  
• Intrinsic and spontaneous neurogenesis in the postnatal slice culture of rat hippocampus

  M Kamada; RY Li; M Hashimoto; M Kakuda; H Okada; Y Koyanagi; T Ishizuka; H Yawo

  EUROPEAN JOURNAL OF NEUROSCIENCE, Nov. 2004, Peer-reviewed

  
• A lentiviral cDNA library employing lambda recombination used to clone an inhibitor of human immunodeficiency virus type 1-induced cell death

  Y Kawano; T Yoshida; K Hieda; J Aoki; H Miyoshi; Y Koyanagi

  JOURNAL OF VIROLOGY, Oct. 2004, Peer-reviewed

  
• Spirodiketopiperazine-based CCR5 inhibitor which preserves CC-Chemokine/CCR5 interactions and exerts potent activity against R5 human immunodeficiency virus type 1 in vitro

  K Maeda; H Nakata; Y Koh; T Miyakawa; H Ogata; Y Takaoka; S Shibayama; K Sagawa; D Fukushima; J Moravek; Y Koyanagi; H Mitsuya

  JOURNAL OF VIROLOGY, Aug. 2004, Peer-reviewed

  
• 免疫不全マウスを用いた子宮内膜症実験モデルにおける移植子宮内膜の性ホルモンへの反応

  小澤由佳; 村上節; 沢田類; 鈴木はるか; 藤井調; 鍋島寛志; 寺田幸弘; 小柳義夫; 八重樫伸生; 岡村州博

  エンドメトリオージス研究会会誌, Jul. 2004, Peer-reviewed

  
• Role of Nup98 in nuclear entry of human immunodeficiency virus type 1 cDNA

  H Ebina; J Aoki; S Hatta; T Yoshida; Y Koyanagi

  MICROBES AND INFECTION, Jul. 2004, Peer-reviewed

  
• Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-alpha

  J Feng; T Misu; K Fujihara; N Misawa; Y Koyanagi; Y Shiga; A Takeda; S Sato; S Takase; T Kohnosu; H Saito; Y Itoyama

  JOURNAL OF NEUROIMMUNOLOGY, Jun. 2004, Peer-reviewed

  
• Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA

  S Baba; K Takahashi; Y Koyanagi; N Yamamoto; H Takaku; RJ Gorelick; G Kawai

  JOURNAL OF BIOCHEMISTRY, Nov. 2003, Peer-reviewed

  
• Quantitative analysis of human immunodeficiency virus type 1 DNA dynamics by real-time PCR: Integration efficiency in stimulated and unstimulated peripheral blood mononuclear cells

  Y Suzuki; N Misawa; C Sato; H Ebina; T Masuda; N Yamamoto; Y Koyanagi

  VIRUS GENES, Oct. 2003, Peer-reviewed

  
• Induction of protective immune responses against R5 human immunodeficiency virus type I (HIV-1) infection in hu-PBL-SCID mice by intrasplenic immunization with HIV-1-Pulsed dendritic cells: Possible involvement of a novel factor of human CD4(+) T-cell origin

  A Yoshida; R Tanaka; T Murakami; Y Takahashi; Y Koyanagi; M Nakamura; M Ito; N Yamamoto; Y Tanaka

  JOURNAL OF VIROLOGY, Aug. 2003, Peer-reviewed

  
• Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gamma c(null) mice: Suppression by an inhibitor against NF-kappa B

  MZ Dewan; K Terashima; M Taruishi; H Hasegawa; M Ito; Y Tanaka; N Mori; T Sata; Y Koyanagi; M Maeda; Y Kubuki; A Okayama; M Fujii; N Yamamoto

  JOURNAL OF VIROLOGY, May 2003, Peer-reviewed

  
• Immunohistochemical localization of steroidogenic enzymes in human follicle following xenotransplantation of the human ovarian cortex into NOD-SCID mice

  Y Sato; Y Terada; H Utsunomiya; Y Koyanagi; M Ito; Miyoshi, I; T Suzuki; H Sasano; T Murakami; N Yaegashi; K Okamura

  MOLECULAR REPRODUCTION AND DEVELOPMENT, May 2003, Peer-reviewed

  
• A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity

  K Ichiyama; S Yokoyama-Kumakura; Y Tanaka; R Tanaka; K Hirose; K Bannai; T Edamatsu; M Yanaka; Y Niitani; N Miyano-Kurosaki; H Takaku; Y Koyanagi; N Yamamoto

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2003, Peer-reviewed

  
• Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection

  Y Miura; N Misawa; Y Kawano; H Okada; Y Inagaki; N Yamamoto; M Ito; H Yagita; K Okumura; H Mizusawa; Y Koyanagi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2003, Peer-reviewed

  
• TNF-related apoptosis-inducing ligand (TRAIL) induces neuronal apoptosis in HIV-encephalopathy

  Y. Miura; Y. Koyanagi; H. Mizusawa

  Journal of Medical and Dental Sciences, 2003, Peer-reviewed

  
• NOD/SCID/gamma(null)(c) mouse: an excellent recipient mouse model for engraftment of human cells

  M Ito; H Hiramatsu; K Kobayashi; K Suzue; M Kawahata; K Hioki; Y Ueyama; Y Koyanagi; K Sugamura; K Tsuji; T Heike; T Nakahata

  BLOOD, Nov. 2002, Peer-reviewed

  
• Isolation and characterization of an infectious HIV type 1 molecular clone from a patient with primary infection

  H Takeuchi; Y Suzuki; M Tatsumi; H Hoshino; ES Daar; Y Koyanagi

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Oct. 2002, Peer-reviewed

  
• Temporary restoration of immune response against Toxoplasma gondii in HIV-infected individuals after HAART, as studied in the hu-PBMC-SCID mouse model

  M Alfonzo; D Blanc; C Troadec; M Huerre; M Eliaszewicz; G Gonzalez; Y Koyanagi; D Scott-Algara

  CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Sep. 2002, Peer-reviewed

  
• Role of nucleotide sequences in the V3 region in efficient replication of CCR5-utilizing human immunodeficiency virus type 1 in macrophages

  T Harada; Y Tsunetsugu-Yokota; Y Koyanagi; T Sata; T Kurata; A Kojima

  VIROLOGY, Aug. 2002, Peer-reviewed

  
• Molecular mechanism of HIV-1 replication

  Y. Kawano; Y. Koyanagi

  Nippon rinsho. Japanese journal of clinical medicine, 2002, Invited

  
• Erratum: Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection (Journal of Virology (1999) 73:9 (7489-7496))

  T. Murakami; T. Y. Zhang; Y. Koyanagi; Y. Tanaka; J. Kim; Y. Suzuki; S. Minoguchi; H. Tamamura; M. Waki; A. Matsumoto; N. Fujii; H. Shida; J. A. Hoxie; S. C. Peiper; N. Yamamoto

  Journal of Virology, 2002, Peer-reviewed

  
• Genetic analysis of HIV type 2 from Ghana and Guinea-Bissau, West Africa

  K Ishikawa; W Janssens; JS Banor; T Shinno; J Piedade; T Sata; WK Ampofo; JAM Brandful; Y Koyanagi; N Yamamoto; WF Canas-Ferreira; Y Adu-Sarkodie; T Kurata

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Nov. 2001, Peer-reviewed

  
• Two Basic Regions of NCp7 are Sufficient for Conformational Conversion of HIV-1 Dimerization Initiation Site from Kissing-loop Dimer to Extended-duplex Dimer

  Ken-Ichi Takahashi; Seiki Baba; Yoshio Koyanagi; Naoki Yamamoto; Hiroshi Takaku; Gota Kawai

  Journal of Biological Chemistry, 17 Aug. 2001, Peer-reviewed

  
• OX40 stimulation by gp34/OX40 ligand enhances productive human immunodeficiency virus type 1 infection

  Y Takahashi; Y Tanaka; A Yamashita; Y Koyanagi; M Nakamura; N Yamamoto

  JOURNAL OF VIROLOGY, Aug. 2001, Peer-reviewed

  
• Isolation and characterization of a full-length molecular DNA clone of Ghanaian HIV type 1 intersubtype A/G recombinant CRF02_AG, which is replication competent in a restricted host range

  S Kusagawa; Y Takebe; RG Yang; K Motomura; W Ampofo; J Brandful; Y Koyanagi; N Yamamoto; T Sata; K Ishikawa; Y Nagai; M Tatsumi

  AIDS RESEARCH AND HUMAN RETROVIRUSES, May 2001, Peer-reviewed

  
• Critical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4(+) T cells in HIV-1-infected hu-PBL-NOD-SCID mice

  Y Miura; N Misawa; N Maeda; Y Inagaki; Y Tanaka; M Ito; N Kayagaki; N Yamamoto; H Yagita; H Mizusawa; Y Koyanagi

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2001, Peer-reviewed

  
• Conformational change of dimerization initiation site of HIV-1 genomic RNA by NCp7 or heat treatment.

  S. Baba; K. Takahashi; Y. Nomura; S. Noguchi; Y. Koyanagi; N. Yamamoto; H. Takaku; G. Kawai

  Nucleic Acids Res Suppl, 2001, Peer-reviewed

  
• HIV感染病態におけるTH1・TH2

  小柳 義夫; 鈴木 陽一

  日本臨床免疫学会会誌, Aug. 2000

  
• NMR analysis of intra- and inter-molecular stems in the dimerization initiation site of the HIV-1 genome

  K Takahashi; S Baba; Y Hayashi; Y Koyanagi; N Yamamoto; H Takaku; G Kawai

  JOURNAL OF BIOCHEMISTRY, Apr. 2000, Peer-reviewed

  
• Transcriptional regulation of HIV-1 LTR during antigen-dependent activation of primary T cells by dendritic cells

  Y Tsunetsugu-Yokota; T Kato; S Yasuda; Z Matsuda; Y Suzuki; Y Koyanagi; N Yamamoto; K Akagawa; MW Cho; T Takemori

  JOURNAL OF LEUKOCYTE BIOLOGY, Mar. 2000, Peer-reviewed

  
• Pertussis toxin enhances human immunodeficiency virus type 1 replication

  Y Momoi; K Ichiyama; IH Chowdhury; Y Koyanagi; N Yamamoto

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Mar. 2000, Peer-reviewed

  
• Efficient Replication of Human Immunodeficiency Virus Type 1 in Cytokine Induced CD 4+ T Helper 1 (Th 1)-and Th 2-type Conditions

  Yoshio Koyanagi

  Japanese Journal of Clinical Immunology, 2000, Peer-reviewed

  
• Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome

  KI Takahashi; S Baba; P Chattopadhyay; Y Koyanagi; N Yamamoto; H Takaku; G Kawai

  RNA-A PUBLICATION OF THE RNA SOCIETY, Jan. 2000, Peer-reviewed

  
• Acquisition of HIV type 1 resistance by beta-chemokine-producing CD4(+) T cells

  N Maeda; Y Koyanagi; N Misawa; N Miyano-Kurosaki; J Kira; N Yamamoto

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Nov. 1999, Peer-reviewed

  
• Coxsackievirus B4 myocarditis in an orangutan

  J Miyagi; K Tsuhako; T Kinjo; T Iwamasa; Y Kamada; T Kinju; Y Koyanagi

  VETERINARY PATHOLOGY, Sep. 1999, Peer-reviewed

  
• Seroreactivity clarification and viral load quantitation in HIV-1 and HIV-2 infections in Ghana

  Kwabena Ampofo William; Koyanagi Yoshio; Brandful Jim; Ishikawa Koichi; Yamamoto Naoki

  Journal of Medical and Dental Sciences, 1999, Peer-reviewed

  
• Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection

  Tsutomu Murakami; Tian-Yuan Zhang; Yoshio Koyanagi; Yuetsu Tanaka; Jin Kim; Yoichi Suzuki; Shigeru Minoguchi; Hirokazu Tamamura; Michinori Waki; Akiyoshi Matsumoto; Nobutaka Fujii; Hisatoshi Shida; James A. Hoxie; Stephen C. Peiper; Naoki Yamamoto

  Journal of Virology, 1999, Peer-reviewed

  
• Epitope mapping of rat neutralizing monoclonal antibody against human immunodeficiency virus type-1 by a phage peptide library: Comparison with ELISA using synthetic peptides

  K Ichiyama; D Ishikawa; Y Tanaka; T Kashiwa; Y Koyanagi; S Handa; A Yamashita; M Fukushi; N Yamamoto; T Taki

  VIRAL IMMUNOLOGY, 1999, Peer-reviewed

  
• Determinant in human immunodeficiency virus type 1 for efficient replication under cytokine-induced CD4+ T-helper 1 (Th1)- and Th2-type conditions

  Y Suzuki; Y Koyanagi; Y Tanaka; T Murakami; N Misawa; N Maeda; T Kimura; H Shida; JA Hoxie; WA O'Brien; N Yamamoto

  JOURNAL OF VIROLOGY, Jan. 1999, Peer-reviewed

  
• Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection

  Murakami T; Zhang TY; Koyanagi Y; Tanaka Y; Kim J; Suzuki Y; Minoguchi S; Tamamura H; Waki M; Matsumoto A; Fujii N; Shida H; Hoxie JA; Peiper SC; Yamamoto N

  Viral Immunology, 1999, Peer-reviewed

  
• High-level production of alternatively spliced soluble interleukin-6 receptor in serum of patients with adult T-cell leukaemia HTLV-I-associated myelopathy

  S Horiuchi; W Ampofo; Y Koyanagi; A Yamashita; M Waki; A Matsumoto; M Yamamoto; N Yamamoto

  IMMUNOLOGY, Nov. 1998, Peer-reviewed

  
• 【AIDS研究最前線】CD4+T細胞サブセットとHIV感染

  鈴木 陽一; 小柳 義夫

  最新医学, Sep. 1998

  
• Replication of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus strain mac (SIVmac) and chimeric HIV-1/SIVmac viruses having env genes derived from macrophage-tropic viruses: an indication of different mechanisms of macrophage-tropism in human and monkey cells

  JL Chen; E Ido; MH Jin; T Kuwata; T Igarashi; A Mizuno; Y Koyanagi; M Hayami

  JOURNAL OF GENERAL VIROLOGY, Apr. 1998, Peer-reviewed

  
• Extensive intra-alveolar haemorrhage caused by disseminated strongyloidiasis

  T Kinjo; K Tsuhako; Nakazato, I; E Ito; Y Sato; Y Koyanagi; T Iwamasa

  INTERNATIONAL JOURNAL FOR PARASITOLOGY, Feb. 1998, Peer-reviewed

  
• HIV-1 strain dependent preferences in Th1- and Th2-type conditions

  Suzuki Y; Koyanagi Y; Tanaka Y; Murakami T; Kimura T; Hoxie JA; O'Brien WA; Yamamoto N

  12th World AIDS Conference, 1998

  
• Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I

  J Kira; K Yamasaki; Yamamoto, I; H Mizusawa; S Yoshino; S Kusunoki; T Yoshida; Y Koyanagi; Y Tanaka; Y Kawano; M Nakamura; M Tsuneyoshi; N Yamamoto; T Kobayashi

  JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, Dec. 1997, Peer-reviewed

  
• Mutational analysis of human immunodeficiency virus type 1 (HIV-1) accessory genes: Requirement of a site in the nef gene for HIV-1 replication in activated CD4(+) T cells in vitro and in vivo

  Y Kawano; Y Tanaka; N Misawa; R Tanaka; J Kira; T Kimura; M Fukushi; K Sano; T Goto; M Nakai; T Kobayashi; N Yamamoto; Y Koyanagi

  JOURNAL OF VIROLOGY, Nov. 1997, Peer-reviewed

  
• A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection

  T Murakami; T Nakajima; N Koyanagi; K Tachibana; N Fujii; H Tamamura; N Yoshida; M Waki; A Matsumoto; O Yoshie; T Kishimoto; N Yamamoto; T Nagasawa

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 1997, Peer-reviewed

  
• CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry

  K Tachibana; T Nakajima; A Sato; K Igarashi; H Shida; H Iizasa; N Yoshida; O Yoshie; T Kishimoto; T Nagasawa

  JOURNAL OF EXPERIMENTAL MEDICINE, May 1997, Peer-reviewed

  
• Altered interleukin-2 receptor alpha-chain is expressed in human T-cell leukaemia virus type-I-infected T-cell lines and human peripheral blood mononuclear cells of adult T-cell leukaemia patients through an alternative splicing mechanism

  S Horiuchi; Y Koyanagi; Y Tanaka; M Waki; A Matsumoto; YW Zhou; M Yamamoto; N Yamamoto

  IMMUNOLOGY, May 1997, Peer-reviewed

  
• Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract

  S Tsukahara; J Suzuki; T Hiratou; K Takai; Y Koyanagi; N Yamamoto; H Takaku

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 1997, Peer-reviewed

  
• Long term, high dose interferon-alpha treatment in HTLV-I-associated myelopathy/tropical spastic paraparesis: A combined clinical, virological and immunological study

  K Yamasaki; J Kira; Y Koyanagi; Y Kawano; N MiyanoKurosaki; M Nakamura; E Baba; J Suzuki; A Yamamoto; N Yamamoto; T Kobayashi

  JOURNAL OF THE NEUROLOGICAL SCIENCES, Apr. 1997, Peer-reviewed

  
• Primary human immunodeficiency virus type 1 viremia and central nervous system invasion in a novel hu-PBL-immunodeficient mouse strain

  Y Koyanagi; Y Tanaka; J Kira; M Ito; K Hioki; N Misawa; Y Kawano; K Yamasaki; R Tanaka; Y Suzuki; Y Ueyama; E Terada; T Tanaka; M Miyasaka; T Kobayashi; Y Kumazawa; N Yamamoto

  JOURNAL OF VIROLOGY, Mar. 1997, Peer-reviewed

  
• High-efficiency transduction of human lymphoid progenitor cells and expression in differentiated T cells

  DS An; Y Koyanagi; JQ Zhao; R Akkina; G Bristol; N Yamamoto; JA Zack; ISY Chen

  JOURNAL OF VIROLOGY, Feb. 1997, Peer-reviewed

  
• Mutational analysis of the 5' noncoding region of human immunodeficiency virus type 1 genome

  Masami Hirota

  Leukemia, 1997, Peer-reviewed

  
• High levels of viremia in HU-PBL-NOD-SCID mice with HIV-1 infection

  Y. Koyanagi; Y. Tanaka; R. Tanaka; N. Misawa; Y. Kawano; T. Tanaka; M. Miyasaka; M. Ito; Y. Ueyama; N. Yamamoto

  Leukemia, 1997, Peer-reviewed

  
• Productive and lytic infection of human CD4(+) type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1

  Y Tanaka; Y Koyanagi; R Tanaka; Y Kumazawa; T Nishimura; N Yamamoto

  JOURNAL OF VIROLOGY, Jan. 1997, Peer-reviewed

  
• Inoculation of human T cell leukemia virus type-I-producing T cell line from a HAM/TSP patient induces autoimmune arthritis and mesenchymal tumors as well as myeloneuropathy associated with autoantibodied against neural antigens in rats.

  吉良潤一; 小柳 義夫

  AIDS Research and human Retroviruses 16, 380-392, 1997, Peer-reviewed

  
• Genetic and phylogenetic analysis of HIV type I env subtypes in Ghana, West Africa

  K Ishikawa; W Janssens; J Brandful; L Heyndrickx; Y Takebe; W Ampofo; T Sata; S Yamazaki; M OseiKwasi; N Yamamoto; Y Koyanagi; G vanderGroen; T Kurata

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Nov. 1996, Peer-reviewed

  
• Human papillomavirus DNA in squamous cell carcinoma of the lung

  T Hirayasu; T Iwamasa; Y Kamada; Y Koyanagi; H Usuda; K Genka

  JOURNAL OF CLINICAL PATHOLOGY, Oct. 1996, Peer-reviewed

  
• The association of antibodies against human T cell lymphotropic virus type I (HTLV-I) pX gene mutant products with HTLV-I-associated myelopathy/tropical spastic paraparesis

  J Suzuki; J Kira; E Baba; M Nakamura; Y Koyanagi; T Nakamura; Y Kawano; K Yamasaki; S Shirabe; N Hatano; K Hayashi; N Yamamoto; T Kobayashi

  JOURNAL OF INFECTIOUS DISEASES, May 1996, Peer-reviewed

  
• Inhibition of gene expression by oligonucleotides forming triple-helices with the polypurine tract of HIV-1.

  Tsukahara S; Suzuki J; Goto Y; Inagawa T; Takeuchi H; Takai K; Koyanagi Y; Yamamoto N; Takaku H

  Nucleic Acids Symposium Series, 1996, Peer-reviewed

  
• Inhibition of HTLV-I induction and virus-induced syncytia formation by oligodeoxynucleotides

  N MiyanoKurosaki; Y Koyanagi; M Mizuguchi; S Ohki; K Makino; N Yamamoto

  VIRUS GENES, 1996, Peer-reviewed

  
• INDUCTION OF ANTIBODY-RESPONSES THAT NEUTRALIZE HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I INFECTION IN-VITRO AND IN-VIVO BY PEPTIDE IMMUNIZATION

  Y TANAKA; R TANAKA; E TERADA; Y KOYANAGI; N MIYANOKUROSAKI; N YAMAMOTO; E BABA; M NAKAMURA; H SHIDA

  JOURNAL OF VIROLOGY, Oct. 1994, Peer-reviewed

  
• CELL-TYPE-SPECIFIC HETEROGENEITY OF THE HIV-1 V3 LOOP IN INFECTED INDIVIDUALS - SELECTION OF VIRUS IN MACROPHAGES AND PLASMA

  A YAMASHITA; N YAMAMOTO; J MATSUDA; Y KOYANAGI

  VIROLOGY, Oct. 1994, Peer-reviewed

  
• PERTUSSIS TOXIN INHIBITS INDUCTION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 IN INFECTED MONOCYTES

  IH CHOWDHURY; Y KOYANAGI; O HAZEKI; M UI; N YAMAMOTO

  VIROLOGY, Sep. 1994, Peer-reviewed

  
• SEQUENCE HETEROGENEITY OF HTLV-I PROVIRAL DNA IN THE CENTRAL-NERVOUS-SYSTEM OF PATIENTS WITH HTLV-I-ASSOCIATED MYELOPATHY

  J KIRA; Y KOYANAGI; T YAMADA; Y ITOYAMA; J TATEISHI; S AKIZUKI; M KISHIKAWA; E BABA; M NAKAMURA; J SUZUKI; T NAKAMURA; N NAKAMURA; N YAMAMOTO; GOTO, I

  ANNALS OF NEUROLOGY, Aug. 1994, Peer-reviewed

  
• SOLUBLE INTERLEUKIN-6 RECEPTORS RELEASED FROM T-CELL OR GRANULOCYTE/MACROPHAGE CELL-LINES AND HUMAN PERIPHERAL-BLOOD MONONUCLEAR-CELLS ARE GENERATED THROUGH AN ALTERNATIVE SPLICING MECHANISM

  S HORIUCHI; Y KOYANAGI; YW ZHOU; H MIYAMOTO; Y TANAKA; M WAKI; A MATSUMOTO; M YAMAMOTO; N YAMAMOTO

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 1994, Peer-reviewed

  
• INTERVENTION OF THE HIV REPLICATION IN THE INITIAL STEP OF INFECTION

  N YAMAMOTO; Y OSHIRO; T MURAKAMI; T MIZUOCHI; T OHWADA; S FUJITA; A YAMASHITA; Y KOYANAGI; H SHIDA; N FUJII

  JAPANESE JOURNAL OF MEDICAL SCIENCE & BIOLOGY, Apr. 1994, Peer-reviewed

  
• MYCOPLASMA STIMULATES HIV-1 EXPRESSION FROM ACUTELY-INFECTED AND DORMANTLY-INFECTED PROMONOCYTE MONOBLASTOID CELL-LINES

  MIH CHOWDHURY; T MUNAKATA; Y KOYANAGI; S ARAI; N YAMAMOTO

  ARCHIVES OF VIROLOGY, 1994, Peer-reviewed

  
• IN-VIVO INFECTION OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I IN NON-T-CELLS

  Y KOYANAGI; Y ITOYAMA; N NAKAMURA; K TAKAMATSU; JI KIRA; T IWAMASA; GOTO, I; N YAMAMOTO

  VIROLOGY, Sep. 1993, Peer-reviewed

  
• CAMP STIMULATES HUMAN-IMMUNODEFICIENCY-VIRUS (HIV-1) FROM LATENTLY INFECTED-CELLS OF MONOCYTE-MACROPHAGE LINEAGE - SYNERGISM WITH TNF-ALPHA

  MIH CHOWDHURY; Y KOYANAGI; S HORIUCHI; O HAZEKI; M UI; K KITANO; DW GOLDE; K TAKADA; N YAMAMOTO

  VIROLOGY, May 1993, Peer-reviewed

  
• DUAL INFECTION OF HIV-1 AND HTLV-I IN SOUTH-INDIA - A STUDY ON A PATIENT WITH AIDS-RELATED COMPLEX

  Y KOYANAGI; T YOSHIDA; M SUZUKI; A UMA; L ANANTHASUBRAMANIAM; S RAMAJAYAM; N YAMAMOTO

  MICROBIOLOGY AND IMMUNOLOGY, 1993, Peer-reviewed

  
• A NOVEL ANTI-HIV SYNTHETIC PEPTIDE, T-22 ([TYR5,12,LYS7]-POLYPHEMUSIN-II)

  M MASUDA; H NAKASHIMA; T UEDA; H NABA; R IKOMA; A OTAKA; Y TERAKAWA; H TAMAMURA; T IBUKA; T MURAKAMI; Y KOYANAGI; M WAKI; A MATSUMOTO; N YAMAMOTO; S FUNAKOSHI; N FUJII

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1992, Peer-reviewed

  
• STRUCTURE-ACTIVITY-RELATIONSHIPS OF TACHYPLESIN ANALOGS AS ANTI-HIV AGENT

  M MASUDA; H NAKASHIMA; T UEDA; H NABA; R IKOMA; S FUNAKOSHI; T MURAKAMI; Y KOYANAGI; N YAMAMOTO; N FUJII

  JOURNAL OF PHARMACOBIO-DYNAMICS, Jul. 1992, Peer-reviewed

  
• ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS ACTIVITY OF A NOVEL SYNTHETIC PEPTIDE, T22 ([TYR-5,12, LYS-7]POLYPHEMUSIN II) - A POSSIBLE INHIBITOR OF VIRUS-CELL FUSION

  H NAKASHIMA; M MASUDA; T MURAKAMI; Y KOYANAGI; A MATSUMOTO; N FUJII; N YAMAMOTO

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Jun. 1992, Peer-reviewed

  
• HEPATITIS-C VIRUS PROPAGATES IN SALIVARY-GLANDS

  K TAKAMATSU; OKAYASU, I; Y KOYANAGI; N YAMAMOTO

  JOURNAL OF INFECTIOUS DISEASES, May 1992, Peer-reviewed

  
• INDUCTION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA IN BRAIN CULTURES BY HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

  JE MERRILL; Y KOYANAGI; J ZACK; L THOMAS; F MARTIN; ISY CHEN

  JOURNAL OF VIROLOGY, Apr. 1992, Peer-reviewed

  
• DEVELOPMENT OF A SUPERSENSITIVE POLYMERASE CHAIN-REACTION METHOD FOR HUMAN T-LYMPHOTROPIC VIRUS TYPE-II (HTLV-II) AND DETECTION OF HTLV-II PROVIRAL DNA FROM BLOOD-DONORS IN JAPAN

  T HAMAKADO; T MATSUMOTO; Y KOYANAGI; K HAYASHI; K FUKADA; T KOUCHIYAMA; T YOSHIDA; N YAMAMOTO

  VIRUS GENES, Apr. 1992, Peer-reviewed

  
• PRESENCE OF HTLV-I PROVIRAL DNA IN CENTRAL-NERVOUS-SYSTEM OF PATIENTS WITH HTLV-I-ASSOCIATED MYELOPATHY

  J KIRA; Y ITOYAMA; Y KOYANAGI; J TATEISHI; M KISHIKAWA; S AKIZUKI; KOBAYASHI, I; N TOKI; K SUEISHI; H SATO; Y SAKAKI; N YAMAMOTO; GOTO, I

  ANNALS OF NEUROLOGY, Jan. 1992, Peer-reviewed

  
• INCREASED PRODUCTION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) IN HIV-INDUCED SYNCYTIA FORMATION - AN EFFICIENT INFECTION PROCESS

  MIH CHOWDHURY; Y KOYANAGI; M SUZUKI; S KOBAYASHI; K YAMAGUCHI; N YAMAMOTO

  VIRUS GENES, Jan. 1992, Peer-reviewed

  
• ANTIBODY-TITERS TO HTLV-I-P40TAX PROTEIN AND GAG-ENV HYBRID PROTEIN IN HTLV-I-ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS - CORRELATION WITH INCREASED HTLV-I PROVIRAL DNA LOAD

  J KIRA; M NAKAMURA; T SAWADA; Y KOYANAGI; N OHORI; Y ITOYAMA; N YAMAMOTO; Y SAKAKI; GOTO, I

  JOURNAL OF THE NEUROLOGICAL SCIENCES, Jan. 1992, Peer-reviewed

  
• IMMUNOGENICITY OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I (HTLV-I) ANTIGENS FOR CYTOTOXIC LYMPHOCYTES-T IN THE RAT SYSTEM

  Y TANAKA; A ISOBE; M MASUDA; H TOZAWA; Y KOYANAGI; N YAMAMOTO; H SHIDA

  JOURNAL OF IMMUNOLOGY, Nov. 1991, Peer-reviewed

  
• HTLV-II in patients with HTLV-I-associated myelopathy

  Jun-Ichi Kira; Yoshio Koyanagi; Toshinari Hamakado; Yasuto Itoyama; Naoki Yamamoto; Ikuo Goto

  The Lancet, 06 Jul. 1991, Peer-reviewed

  
• INCREASED HTLV-I PROVIRAL DNA IN HTLV-I-ASSOCIATED MYELOPATHY - A QUANTITATIVE POLYMERASE CHAIN-REACTION STUDY

  J KIRA; Y KOYANAGI; T YAMADA; Y ITOYAMA; GOTO, I; N YAMAMOTO; H SASAKI; Y SAKAKI

  ANNALS OF NEUROLOGY, Feb. 1991, Peer-reviewed

  
• LATENT HSV-I INFECTION IN RAT VESTIBULAR GANGLIA

  H SHIMOGORI; T SEKITANI; Y KOYANAGI; N YAMAMOTO

  ACTA OTO-LARYNGOLOGICA, 1991, Peer-reviewed

  
• EVALUATION OF ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS EFFECT OF RECOMBINANT CD4-IMMUNOGLOBULIN INVITRO - A GOOD CANDIDATE FOR AIDS TREATMENT

  IH CHOWDHURY; Y KOYANAGI; K TAKAMATSU; O YOSHIDA; S KOBAYASHI; N YAMAMOTO

  MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 1991, Peer-reviewed

  
• HEPATITIS-C VIRUS-RNA IN SALIVA

  K TAKAMATSU; Y KOYANAGI; K OKITA; N YAMAMOTO

  LANCET, Dec. 1990, Peer-reviewed

  
• HIV-1 TROPISM FOR MONONUCLEAR PHAGOCYTES CAN BE DETERMINED BY REGIONS OF GP120 OUTSIDE THE CD4-BINDING DOMAIN

  WA OBRIEN; Y KOYANAGI; A NAMAZIE; JQ ZHAO; A DIAGNE; K IDLER; JA ZACK; ISY CHEN

  NATURE, Nov. 1990, Peer-reviewed

  
• HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 T-CELL TROPISM IS DETERMINED BY EVENTS PRIOR TO PROVIRUS FORMATION

  AJ CANN; JA ZACK; AS GO; SJ ARRIGO; Y KOYANAGI; PL GREEN; Y KOYANAGI; S PANG; ISY CHEN

  JOURNAL OF VIROLOGY, Oct. 1990, Peer-reviewed

  
• MYCOPLASMA CAN ENHANCE HIV REPLICATION INVITRO - A POSSIBLE COFACTOR RESPONSIBLE FOR THE PROGRESSION OF AIDS

  MIH CHOWDHURY; T MUNAKATA; Y KOYANAGI; S KOBAYASHI; S ARAI; N YAMAMOTO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 1990, Peer-reviewed

  
• MYCOPLASMA AND AIDS

  MIH CHOWDHURY; Y KOYANAGI; S KOBAYASHI; N YAMAMOTO; T MUNAKATA; S ARAI

  LANCET, Jul. 1990, Peer-reviewed

  
• RECOGNITION OF HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I (HTLV-I) GAG AND PX GENE-PRODUCTS BY MHC-RESTRICTED CYTOTOXIC LYMPHOCYTES-T INDUCED IN RATS AGAINST SYNGENEIC HTLV-I-INFECTED CELLS

  Y TANAKA; H TOZAWA; Y KOYANAGI; H SHIDA

  JOURNAL OF IMMUNOLOGY, Jun. 1990, Peer-reviewed

  
• HUMAN-IMMUNODEFICIENCY-VIRUS CAUSES MONONUCLEAR PHAGOCYTE DYSFUNCTION

  GC BALDWIN; J FLEISCHMANN; YG CHUNG; Y KOYANAGI; ISY CHEN; DW GOLDE

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 1990, Peer-reviewed

  
• THE PHORBOL ESTER TPA STRONGLY INHIBITS HIV-1-INDUCED SYNCYTIA FORMATION BUT ENHANCES VIRUS PRODUCTION - POSSIBLE INVOLVEMENT OF PROTEIN KINASE-C PATHWAY

  MIH CHOWDHURY; Y KOYANAGI; S KOBAYASHI; Y HAMAMOTO; H YOSHIYAMA; T YOSHIDA; N YAMAMOTO

  VIROLOGY, May 1990, Peer-reviewed

  
• HIGH-LEVELS OF UNINTEGRATED HIV-1 DNA IN BRAIN-TISSUE OF AIDS DEMENTIA PATIENTS

  S PANG; Y KOYANAGI; S MILES; C WILEY; HV VINTERS; ISY CHEN

  NATURE, Jan. 1990, Peer-reviewed

  
• EFFECT OF INTERLEUKIN-1 ON THE AUGMENTATION OF HUMAN IMMUNODEFICIENCY VIRUS GENE-EXPRESSION

  N KOBAYASHI; Y HAMAMOTO; Y KOYANAGI; ISY CHEN; N YAMAMOTO

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 1989, Peer-reviewed

  
• INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA CAN BE INDUCED FROM MONONUCLEAR PHAGOCYTES BY HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 BINDING TO THE CD4 RECEPTOR

  JE MERRILL; Y KOYANAGI; ISY CHEN

  JOURNAL OF VIROLOGY, Oct. 1989, Peer-reviewed

  
• CYTOKINES ALTER PRODUCTION OF HIV-1 FROM PRIMARY MONONUCLEAR PHAGOCYTES

  Y KOYANAGI; WA OBRIEN; JQ ZHAO; DW GOLDE; JC GASSON; ISY CHEN

  SCIENCE, Sep. 1988, Peer-reviewed

  
• HIGH-EFFICIENCY TRANSFECTION OF PRIMARY HUMAN-LYMPHOCYTES AND STUDIES OF GENE-EXPRESSION

  AJ CANN; Y KOYANAGI; ISY CHEN

  ONCOGENE, Jul. 1988, Peer-reviewed

  
• EXPERIMENTAL APPROACHES TO STUDIES OF PRIMARY CLINICAL ISOLATES OF HIV

  AJ CANN; Y KOYANAGI; ISY CHEN

  CONTROL OF HUMAN RETROVIRUS GENE EXPRESSION, 1988, Peer-reviewed

  
• CLONAL SELECTION OF HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) - SEROLOGICAL DIFFERENCES IN THE ENVELOPE ANTIGENS OF THE CLONED VIRUSES AND HIV PROTOTYPES (HTLV-III-B, LAV, AND ARV)

  S HARADA; N KOBAYASHI; Y KOYANAGI; N YAMAMOTO

  VIROLOGY, Jun. 1987, Peer-reviewed

  
• DUAL INFECTION OF THE CENTRAL-NERVOUS-SYSTEM BY AIDS VIRUSES WITH DISTINCT CELLULAR TROPISMS

  Y KOYANAGI; S MILES; RT MITSUYASU; JE MERRILL; HV VINTERS; ISY CHEN

  SCIENCE, May 1987, Peer-reviewed

  
• RELATIONSHIP OF HUMAN CORD BLOOD MONONUCLEAR CELL-LINES, ESTABLISHED BY THE HTLV-I INTEGRATION, TO EXPRESSION OF T-CELL PHENOTYPES AND THE T-CELL RECEPTOR GENE REARRANGEMENT

  H MIWA; T UCHIDA; T KOBAYASHI; K KITA; S SHIRAKAWA; Y KOYANAGI; N YAMAMOTO; A SHIMIZU; T HONJO; M HATANAKA

  JOURNAL OF MOLECULAR AND CELLULAR IMMUNOLOGY, 1987, Peer-reviewed

  
• TUMOR PROMOTER, TPA, ENHANCES REPLICATION OF HTLV-III LAV

  S HARADA; Y KOYANAGI; H NAKASHIMA; N KOBAYASHI; N YAMAMOTO

  VIROLOGY, Oct. 1986, Peer-reviewed

  
• QUANTITATIVE EVALUATIONS OF THE EFFECT OF UV IRRADIATION ON THE INFECTIVITY OF HTLV-III (AIDS VIRUS) WITH HTLV-I-CARRYING CELL-LINE, MT-4

  H NAKASHIMA; Y KOYANAGI; S HARADA; N YAMAMOTO

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Aug. 1986, Peer-reviewed

  
• DIFFERENTIAL SUSCEPTIBILITY TO THE ACQUIRED-IMMUNODEFICIENCY-SYNDROME RETROVIRUS IN CLONED CELLS OF HUMAN-LEUKEMIC T-CELL LINE MOLT-4

  R KIKUKAWA; Y KOYANAGI; S HARADA; N KOBAYASHI; M HATANAKA; N YAMAMOTO

  JOURNAL OF VIROLOGY, Mar. 1986, Peer-reviewed

  
• ESTABLISHMENT OF A HIGH PRODUCTION SYSTEM FOR AIDS RETROVIRUSES WITH A HUMAN T-LEUKEMIC CELL-LINE MOLT-4

  Y KOYANAGI; S HARADA; N YAMAMOTO

  CANCER LETTERS, Mar. 1986, Peer-reviewed

  
• Infection of HTLV-III/LAV in HTLV-I-carrying cell lines: Virological, immunological and cytological aspects

  N. Yamamoto; Y. Koyanagi; S. Harada

  Tropical Medicine, 1986, Peer-reviewed

  
• DETECTION AND ISOLATION OF AN ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME (AIDS)-RELATED VIRUS (HTLV-III/LAV) FROM A JAPANESE BOY WITH AIDS-RELATED COMPLEX

  H YOSHIYAMA; Y KOYANAGI; H NAKASHIMA; T ISHIHARA; F UCHINO; S HARADA; F OKINO; T KAJII; N YAMAMOTO

  JAPANESE JOURNAL OF CANCER RESEARCH, Jan. 1986, Peer-reviewed

  
• SENSITIVE ASSAY FOR NEUTRALIZING ANTIBODIES AGAINST AIDS-RELATED VIRUSES (HTLV-III/LAV)

  S HARADA; DT PURTILO; Y KOYANAGI; J SONNABEND; N YAMAMOTO

  JOURNAL OF IMMUNOLOGICAL METHODS, 1986, Peer-reviewed

  
• SEROLOGICAL DIFFERENCES BETWEEN HUMAN T-LYMPHOTROPIC VIRUS TYPE-I (HTLV-I) AND HTLV-III LAV

  S HARADA; DT PURTILO; Y KOYANAGI; N YAMAMOTO

  MICROBIOLOGY AND IMMUNOLOGY, 1986, Peer-reviewed

  
• EFFECT OF HTLV-III ON THE MACROMOLECULAR-SYNTHESIS IN HTLV-I CARRYING CELL-LINE, MT-4

  H NAKASHIMA; Y KOYANAGI; S HARADA; N YAMAMOTO

  MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 1986, Peer-reviewed

  
• INFECTION OF HTLV-III/LAV IN HTLV-I-CARRYING CELLS MT-2 AND MT-4 AND APPLICATION IN A PLAQUE-ASSAY

  S HARADA; Y KOYANAGI; N YAMAMOTO

  SCIENCE, 1985, Peer-reviewed

  
• EFFECT OF HUMAN-SERUM ANTI-HTLV ANTIBODIES ON VIRAL-ANTIGEN INDUCTION IN INVITRO CULTURED PERIPHERAL LYMPHOCYTES FROM ADULT T-CELL LEUKEMIA PATIENTS AND HEALTHY VIRUS CARRIERS

  T TOCHIKURA; M IWAHASHI; T MATSUMOTO; Y KOYANAGI; Y HINUMA; N YAMAMOTO

  INTERNATIONAL JOURNAL OF CANCER, 1985, Peer-reviewed

  
• INFECTION OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-I (HTLV-I)-BEARING MT-4 CELLS WITH HTLV-III (AIDS VIRUS) - CHRONOLOGICAL STUDIES OF EARLY EVENTS

  S HARADA; Y KOYANAGI; N YAMAMOTO

  VIROLOGY, 1985, Peer-reviewed

  
• CORRELATION BETWEEN HIGH SUSCEPTIBILITY TO AIDS VIRUS AND SURFACE EXPRESSION OF OKT-4 ANTIGEN IN HTLV-I-POSITIVE CELL-LINES

  Y KOYANAGI; S HARADA; N YAMAMOTO

  JAPANESE JOURNAL OF CANCER RESEARCH, 1985, Peer-reviewed

  
• SELECTIVE CYTO-TOXICITY OF AIDS VIRUS-INFECTION TOWARDS HTLV-I-TRANSFORMED CELL-LINES

  Y KOYANAGI; S HARADA; M TAKAHASHI; F UCHINO; N YAMAMOTO

  INTERNATIONAL JOURNAL OF CANCER, 1985, Peer-reviewed

  
• NATURE OF ADULT T-CELL LEUKEMIA-ASSOCIATED MEMBRANE ANTIGEN ON THE SURFACE OF ADULT T-CELL LEUKEMIA VIRUS-CARRYING CELLS AS REVEALED BY MEMBRANE IMMUNOFLUORESCENCE

  T CHOSA; N YAMAMOTO; Y KOYANAGI; M KOHNO; K NAGATA; Y HINUMA

  MICROBIOLOGY AND IMMUNOLOGY, 1984, Peer-reviewed

  
• INVITRO INFECTION OF HUMAN LYMPHOCYTES-B WITH ADULT T-CELL LEUKEMIA-VIRUS

  M OKADA; Y KOYANAGI; N KOBAYASHI; Y TANAKA; M NAKAI; K SANO; K TAKEUCHI; Y HINUMA; M HATANAKA; N YAMAMOTO

  CANCER LETTERS, 1984, Peer-reviewed

  
• EXPRESSION OF HTLV-SPECIFIC POLYPEPTIDES IN VARIOUS HUMAN T-CELL LINES

  Y KOYANAGI; Y HINUMA; J SCHNEIDER; T CHOSA; G HUNSMANN; N KOBAYASHI; M HATANAKA; N YAMAMOTO

  MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 1984, Peer-reviewed

  
• CHARACTERIZATION OF HUMAN B-CELL LINES HARBORING BOTH ADULT T-CELL LEUKEMIA (ATL) VIRUS AND EPSTEIN-BARR VIRUS DERIVED FROM ATL PATIENTS

  Y KOYANAGI; N YAMAMOTO; N KOBAYASHI; K HIRAI; H KONISHI; K TAKEUCHI; Y TANAKA; M HATANAKA; Y HINUMA

  JOURNAL OF GENERAL VIROLOGY, 1984, Peer-reviewed

  
• A NEW MONOCLONAL-ANTIBODY RECOGNIZING AN ANTIGEN OF HUMAN-LYMPHOCYTES SIMILAR OR IDENTICAL TO TAC ANTIGEN

  Y TANAKA; H TOZAWA; Y KOYANAGI; N YAMAMOTO; Y HINUMA

  MICROBIOLOGY AND IMMUNOLOGY, 1984, Peer-reviewed

  
• 28,000-DALTON POLYPEPTIDE (P-28) OF ADULT T-CELL LEUKEMIA-ASSOCIATED ANTIGEN ENCODED BY 24 S MESSENGER-RNA OF HUMAN T-CELL LEUKEMIA-VIRUS HAS AN ASSOCIATED PROTEIN-KINASE ACTIVITY

  N KOBAYASHI; Y KOYANAGI; N YAMAMOTO; Y HINUMA; H SATO; K OKOCHI; M HATANAKA

  JOURNAL OF BIOLOGICAL CHEMISTRY, 1984, Peer-reviewed

  
• BINDING OF ADULT T-CELL LEUKEMIA-VIRUS TO VARIOUS HEMATOPOIETIC-CELLS

  N YAMAMOTO; T CHOSA; Y KOYANAGI; T TOCHIKURA; J SCHNEIDER; Y HINUMA

  CANCER LETTERS, 1984, Peer-reviewed

  
• TRANSLATION OF HTLV (HUMAN T-CELL LEUKEMIA-VIRUS) RNA IN A NUCLEASE-TREATED RABBIT RETICULOCYTE SYSTEM

  N KOBAYASHI; N YAMAMOTO; Y KOYANAGI; J SCHNEIDER; G HUNSMANN; M HATANAKA

  EMBO JOURNAL, 1984, Peer-reviewed

  
• CHARACTERIZATION OF AFRICAN-GREEN MONKEY B-CELL LINES RELEASING AN ADULT T-CELL LEUKEMIA-VIRUS-RELATED AGENT

  N YAMAMOTO; N KOBAYASHI; K TAKEUCHI; Y KOYANAGI; M HATANAKA; Y HINUMA; T CHOSA; J SCHNEIDER; G HUNSMANN

  INTERNATIONAL JOURNAL OF CANCER, 1984, Peer-reviewed

  
• Detection of antibodies to human T-lymphotropic viruses type I and III in Japanese hemophiliacs

  Y. Koyanagi; S. Kobayashi; S. Harada; R. Kikukawa; N. Yamamoto; K. Watanabe; F. Okino; T. Kajii

  AIDS Research, 1983, Peer-reviewed

  
• MONOCLONAL-ANTIBODY REACTIVE WITH BOTH P-28 AND P19 OF ADULT T-CELL LEUKEMIA VIRUS-SPECIFIC POLYPEPTIDES

  Y TANAKA; Y KOYANAGI; T CHOSA; N YAMAMOTO; Y HINUMA

  GANN, 1983, Peer-reviewed

  
• ADULT T-CELL LEUKEMIA (ATL) VIRUS-SPECIFIC ANTIBODIES IN ATL PATIENTS AND HEALTHY VIRUS CARRIERS

  N YAMAMOTO; J SCHNEIDER; Y KOYANAGI; Y HINUMA; G HUNSMANN

  INTERNATIONAL JOURNAL OF CANCER, 1983, Peer-reviewed

  
• INFECTIVITY DISSOCIATED FROM TRANSFORMING ACTIVITY IN A HUMAN RETROVIRUS, ADULT T-CELL LEUKEMIA-VIRUS

  T CHOSA; N YAMAMOTO; Y TANAKA; Y KOYANAGI; Y HINUMA

  GANN, 1982, Peer-reviewed

  
• UNIQUE CELL-LINES HARBORING BOTH EPSTEIN-BARR VIRUS AND ADULT T-CELL LEUKEMIA-VIRUS, ESTABLISHED FROM LEUKEMIA PATIENTS

  N YAMAMOTO; T MATSUMOTO; Y KOYANAGI; Y TANAKA; Y HINUMA

  NATURE, 1982, Peer-reviewed

  
• TRANSFORMATION OF HUMAN-LEUKOCYTES BY CO-CULTIVATION WITH AN ADULT T-CELL LEUKEMIA-VIRUS PRODUCER CELL-LINE

  N YAMAMOTO; M OKADA; Y KOYANAGI; M KANNAGI; Y HINUMA

  SCIENCE, 1982, Peer-reviewed

  

Misc.

• インテグラーゼ非依存性HIV cDNAの組み込み

  蝦名博貴; 金村優香; 鈴木康嗣; 浦田こずえ; 小柳義夫

  日本分子生物学会年会プログラム・要旨集(Web), 2011

  
• エイズ脳症の小動物モデル (第22回日本エイズ学会シンポジウム記録) -- (HAARTとNeuroAIDS)

  三浦 義治; 小柳 義夫; 水澤 英洋

  日本エイズ学会誌, 2009

  
• Report of Yugawara camp 2008

  KOYANAGI Yoshio

  ウイルス, 24 Dec. 2008

  
• Separate elements are required for ligand-dependent and -independent internalization of metastatic potentiator CXCR4

  FUTAHASHI Yuko; KOMANO Jun; URANO Emiko; AOKI Toru; HAMATAKE Makiko; MIYAUCHI Kosuke; YOSHIDA Takeshi; KOYANAGI Yoshio; MATSUDA Zene; YAMAMOTO Naoki

  Cancer Sci, 10 Mar. 2007

  
• HIV感染症における多様なCD4+T細胞減少のメカニズム (第1土曜特集 AIDS治療:2005-2006) -- (AIDS/HIV-1研究の新展開)

  青木 淳; 小柳 義夫

  医学のあゆみ, 04 Jun. 2005

  
• A New Murine Model of HIV-associated Encephalopathy

  三浦 義治; 小柳 義夫; 水澤 英洋

  Brain and nerve : 神経研究の進歩, Apr. 2004

  
• 【臨床医に必要な生殖免疫の知識】 卵巣移植の免疫 免疫抑制マウスへのヒト卵巣皮質の移植系について

  寺田 幸弘; 佐藤 由美; 宇都宮 裕貴; 村上 節; 八重樫 伸生; 岡村 州博; 小柳 義夫

  産婦人科治療, Jun. 2002

  
• HIV感染とリンパ球アポトーシス

  武内 寛明; 小柳 義夫

  臨床免疫, Feb. 2002

  
• プライマーとしてtRNA^/DNAを用いたHIV-1逆転写/テンプレート交換反応の効率

  金塚 康浩; 細谷 武士; 高井 和幸; 小柳 義夫; 上田 卓也; 山本 直樹; 渡辺 公綱; 高久 洋

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Effects of Dumbbell Oligonucleotides on Transcription of HIV-1 Proviral DNA.

  HOSOYA TAKESHI; YAMAKAWA HIDEFUMI; TAKAI KAZUYUKI; KOYANAGI YOSHIO; YAMAMOTO NAOKI; TAKAKU HIROSHI

  日本化学会講演予稿集, Mar. 1997

  
• Epidermal Langerhans cells infected with CCR5-tropic HIV, but not dermal dendritic cells, transmit virus to T cells in a novel skin explant model system

  T. Kawamura; Y. Nakamura; Y. Ogawa; Y. Koyanagi; A. Blauvelt; S. Shimada

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Apr. 2006

  
• 技術講座 SCID-hu Thy/Livマウス

  三浦 義治; 小柳 義夫

  細胞, Oct. 2000

  
• The Order of Culture 2009 : Professor Yorio HINUMA

  KOYANAGI Yoshio

  ウイルス, 01 Jun. 2010

  
• Model of Viral Infection in SCID mice : SCID-hu mouse and hu-PBL-SCID Mouse

  KOYANAGI Yoshio

  Virus, 01 Jun. 1999

  
• Determinant in human immunodeficiency virus type 1 for′ efficient replication under cytokine-induced CD4+ T-helper 1′ (Th1)- and Th2-type conditions.

  Suzuki Y.; Koyanagi Y.; Tanaka Y.; Murakami T.; Misawa ′ N.; Maeda N.; Kimura T.; Shida H.; Hoxie J.A.; O'Brien ′ W.A.; Yamamoto N.

  Collected papers from Institute for Genetic Medicine Hokkaido University, 1999

  
• HIV治癒へのオミクス解析

  佐藤佳; 佐藤佳; 佐藤佳; 三沢尚子; 長岡俊平; 麻生啓文; 川上英良; 中岡慎治; 城口克之; 佐藤賢文; 小柳義夫

  日本エイズ学会誌, 2018

  
• ヒト化マウスを用いたヒト特異的疾患研究のイノベーション : 応用数学と実験医学の融合

  岩見 真吾; 佐藤 佳; 小柳 義夫

  応用数理, 26 Jun. 2012

  
• E-26 HIV-1 適応進化過程の解明

  小柳 義夫; 小林 朋子; 佐藤 佳; 柴田 潤子; 福原 充子; 三沢 尚子

  霊長類研究所年報, 13 Nov. 2013

  Access this misc :

  
• 公共データベースを活用したエボラウイルスGP遺伝子の感染効率に関与する塩基突然変異の同定

  中川草; 上田真保子; 中野雄介; 安田二朗; 小柳義夫; 佐藤佳; 佐藤佳; 黒崎陽平

  日本獣医学会学術集会講演要旨集, Aug. 2018

  
• 新規RNA分解酵素によるHIV-1感染制御機構の解明

  山岨大智; 佐藤佳; 佐藤佳; 小柳義夫; 竹内理

  日本生体防御学会学術総会講演抄録集, 2018

  
• MALT1によるN4BP1の分解は潜伏感染HIV-1の再活性化を促進する

  山岨大智; 佐藤佳; 小柳義夫; 竹内理

  日本エイズ学会誌, 2018

  
• 【ウイルスの増殖・病態発現機構に関する最新の知見】 AIDSウイルスとヒトの進化的軍拡競争 ウイルス蛋白質とヒト蛋白質の相互作用からみえてくる進化的せめぎあい

  佐藤 佳; 小柳 義夫

  医学のあゆみ, Feb. 2017

  
• Interplay between HIV-1 and APOBEC

  Kei Sato; Yoshio Koyanagi

  Seikagaku, 2016

  
• エボラウイルス糖蛋白質の82番目と544番目のアミノ酸変異は感染効率に関与する

  上田真保子; 黒崎陽平; 泉泰輔; 中野雄介; オロニニ オラミデ; 安田二朗; 小柳義夫; 佐藤佳; 中川草; 中川草

  日本分子生物学会年会プログラム・要旨集(Web), 2016

  
• RGN発現レンチウイルスベクターによるHIV-1複製抑制

  上田 修平; 蝦名 博貴; 三沢 尚子; 金村 優香; 小柳 義夫

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• ゲノム編集で細胞・生物をカスタマイズする HIVの研究におけるゲノム編集技術(Genome-editing technologies in HIV research)

  蝦名 博貴; 上田 修平; 金村 優香; 三沢 尚子; 小柳 義夫

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• ウシ族の進化過程におけるAPOBEC3Z2蛋白質の発現レベル多様性の出現

  中野 雄介; 山田 英里; 吉川 禄助; 泉 泰輔; 小林 朋子; 三沢 尚子; 任 鳳蓉; 佐藤 佳; 小柳 義夫

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• 自然発生Vif変異によるレンチウイルスの弱毒化

  吉川 禄助; 竹内 潤子; 田; 山田 英里; 中野 雄介; 木村 雄一; 橋本 暁; 宮沢 孝幸; 佐藤 佳; 小柳 義夫

  日本獣医学会学術集会講演要旨集, Aug. 2015

  
• 【HIV制御のための宿主防御因子研究の展開】 HIV感染における宿主因子SAMHD1の役割

  金村 優香; 小柳 義夫

  日本エイズ学会誌, Feb. 2015

  
• 【ゲノム編集-基礎から応用へ】 ゲノム編集とAIDS治療

  蝦名 博貴; 小柳 義夫

  医学のあゆみ, Jan. 2015

  
• 抗HIV薬投与下の治療ワクチン接種により誘導されるCD8陽性T細胞のSIV複製抑制能の解析

  中村 碧; 高原 悠佑; 松岡 佐織; 團塚 愛; 三浦 智行; 小柳 義夫; 成瀬 妙子; 木村 彰方; 俣野 哲朗

  日本エイズ学会誌, Nov. 2014

  
• HIV感染の予防とウイルスの除去を目指した戦略を考える ゲノム編集法を用いたエイズ治療戦略の展望

  蝦名 博貴; 三沢 尚子; 金村 優香; 小柳 義夫

  日本エイズ学会誌, Nov. 2014

  
• 霊長類レンチウイルスのNefタンパク質の機能的進化とその意義

  中野 雄介; 吉川 禄助; 山田 英里; 小林 朋子; 竹内 潤子; 田; 三沢 尚子; 小柳 義夫

  日本エイズ学会誌, Nov. 2014

  
• Anti‐CCR4抗体はTregと感染細胞を同時に標的にする事で,STLV‐1自然感染ニホンザルでのウイルス特異的免疫反応を活性化させる

  SUGATA KENJI; YASUNAGA JUN'ICHIRO; MIURA MICHI; AKARI HIROFUMI; KOYANAGI YOSHIO; KOHARA MICHINORI; MATSUOKA MASAO

  日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2014

  
• SIVの持続感染・伝播における変異蓄積に関する研究

  関紗由里; 野村拓志; 西澤雅子; 横山勝; 佐藤裕徳; 團塚愛; 三浦智行; 小柳義夫; 俣野哲朗

  日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2014

  
• 【ウイルス感染と免疫】 単純ヘルペスウイルスの感染防御にかかわる細胞性因子APOBEC1とSAMHD1

  小柳 義夫

  臨床免疫・アレルギー科, Sep. 2014

  
• インターフェロン誘導性新規抗デングウイルス因子(RyDEN)の同定とその抑制機構の解明

  鈴木陽一; 鈴木陽一; HAN Qi’En; CHIN Wei Xin; LEE Ching Hua; WEN Eyo Zhi; 蝦名博貴; 市山浩二; TAN Beng Hui; 日紫喜隆行; 大庭賢二; HANN Chu Jang; TAN Yee Joo; 小柳義夫; VASUDEVAN Subhash; 山本直樹

  日本ウイルス学会学術集会プログラム・抄録集, 2014

  
• HIV-1感染ヒト化マウスモデルを用いたAPOBEC3G/Fの機能解析

  竹内 潤子; 柴田; 佐藤 佳; 三沢 尚子; 泉 泰輔; 小林 朋子; 木村 雄一; 岩見 真吾; 高折 晃史; Hu Wei-Shau; 合原 一幸; 伊藤 守; An Dong Sung; Pathak Vinay K; 小柳 義夫

  日本エイズ学会誌, Nov. 2013

  
• 基礎 感染機構、複製 ゲノム編集技術による潜伏HIVプロウイルスの制御と除去

  蝦名 博貴; 三沢 尚子; 金村 優香; 小柳 義夫

  日本エイズ学会誌, Nov. 2013

  
• 組換えウイルスを用いた抗HTLV‐1ワクチンの作製とMacaque属での応用

  KANDA KENJI; YASUNAGA JUN'ICHIRO; MIURA MICHI; AKARI HIROFUMI; KOYANAGI YOSHIO; KOHARA MICHINORI; MATSUOKA MASAO

  日本ウイルス学会学術集会プログラム・抄録集, 29 Oct. 2013

  
• サルエイズモデルにおける抗HIV薬投与下のCTL誘導治療ワクチン接種によるSIV増殖抑制能の増強効果の解析

  中村碧; 高原悠佑; 松岡佐織; 三浦智行; 小柳義夫; 成瀬妙子; 木村彰方; 俣野哲朗

  日本ウイルス学会学術集会プログラム・抄録集, 29 Oct. 2013

  
• 【HIV感染症2013〜現状と展望〜】 抗HIV-1宿主因子研究の最前線 Tetherin & SAMHD1

  小林 朋子; 小柳 義夫

  血液フロンティア, May 2013

  
• 生体内HIV-1複製におけるVpuの機能解析

  佐藤 佳; 三沢 尚子; 福原 充子; 岩見 真吾; An Dong Sung; 伊藤 守; 小柳 義夫

  日本エイズ学会誌, Nov. 2012, Peer-reviewed

  
• サルエイズモデルにおける抗HIV薬投与下のCTL誘導治療ワクチン接種効果の解析

  中村 碧; 高原 悠佑; 松岡 佐織; 阪脇 廣美; 三浦 智行; 五十嵐 樹彦; 小柳 義夫; 成瀬 妙子; 木村 彰方; 俣野 哲朗

  日本エイズ学会誌, Nov. 2012

  
• Vprの制御性T細胞特異的な消耗促進作用による生体内HIV‐1増殖亢進

  SATO KEI; MISAWA NAOKO; SATO YORIFUMI; MATSUOKA MASAO; ITO MAMORU; KOYANAGI YOSHIO

  日本ウイルス学会学術集会プログラム・抄録集, 31 Oct. 2012

  
• 【ナノバイオ技術と最新創薬応用研究】 (第3章)ウイルス、免疫とナノバイオ創薬 細胞性HIV抑制因子とその創薬展開

  小柳 義夫

  遺伝子医学MOOK, Jan. 2012

  
• Induction of immune activation by the depletion of regulatory CD4 十T cell during acute HIV-1 infection in \nhumanized mouse model.

  Sato K; Misawa N; Satou Y; Matsuoka M; Ito M; Koyanagi Y

  19th Conference on Retroviruses and Opportunistic Infections (CROI) 、poster ,Seattle ,2012 年3 月5 日, 2012, Peer-reviewed

  
• 生細胞におけるHIV cDNA の可視化とイメージング

  蝦名博貴; 金村優香; 小柳義夫

  第35回日本分子生物学会年会、福岡.2012 年12 月11 日, 2012, Peer-reviewed

  
• 細胞特異的な耗促進作用による生体内HIV-1増殖亢進

  佐藤挂; 三沢尚子; 佐藤賢文; 松岡雅雄; 伊藤守; 小柳義夫

  第60 回日本ウイルス学会学術集会、大阪. 2012 年11 月14 日 \n, 2012, Peer-reviewed

  
• HIV cDNA の可視化とライブイメージングの確立

  蝦名博貴; 金村優香; 小柳義夫

  第60 回日本ウイルス学会学術集会、大阪. 2012年11 月13 日, 2012, Peer-reviewed

  
• ウイルス性膜タンパク質Vpu による生体内HIV-1 増殖促進作用

  佐藤佳; 三沢尚子; 福原充子; 岩見真吾; 伊藤守; 小柳義夫

  第35 回日本分子生物学会、福岡. 2012 年12 月 12 日, 2012, Peer-reviewed

  
• 数理モデルを用いたエンテロウイルス71複製ダイナミクスの解析

  福原充子; 岩見真吾; 佐藤佳; 小柳義夫

  第35 回日本分子生物学会、福岡.2012年12月11 日, 2012, Peer-reviewed

  
• ベータレトロウイルスの新規抗BST2活性

  福原充子; 佐藤佳; 吉川禄助; 宮沢孝幸; 小柳義夫

  第60 回日本ウイルス学会学術集会、大阪. 2012 年11 月15 日, 2012, Peer-reviewed

  
• 培養細胞実験の数理モデリングを用いたウイルスダイナミクスにおけるVpr機能の解明

  岩見 真吾; 佐藤 佳; 小柳 義夫

  日本エイズ学会誌, Nov. 2011, Peer-reviewed

  
• 感染機構とその制御 急性感染期のHIV-1増殖における制御性T細胞とVprの寄与

  佐藤 佳; 三沢 尚子; 佐藤 賢文; 松岡 雅雄; 伊藤 守; 小柳 義夫

  日本エイズ学会誌, Nov. 2011

  
• A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice

  Kei Sato; Naoko Misawa; Chuanyi Nie; Yorifumi Satou; Dai Iwakiri; Masao Matsuoka; Rei Takahashi; Kiyotaka Kuzushima; Mamoru Ito; Kenzo Takada; Yoshio Koyanagi

  BLOOD, May 2011, Peer-reviewed

  
• HIV-1 Vpr protein accelerates HIV-1 replication during acute phase in vivo

  Sato K; Misawa N; I to M; Koyanagi Y

  3rd International Workshop on Humanized mice, Pittsburgh, USA, 2011年10月29日, 2011, Peer-reviewed

  
• Mutagenesis and Molecular Modeling Studies Reveal Structural Insights into Human Tetherin Recognition by HIV-1 Vpu.

  Kobayashi T; Ode H; Yoshida T; Sato K; Gee P; Yamamoto S.P; Ebina H; Strebel K; Sato H; Koyanagi Y

  18th Conference on Retroviruses and Opportunistic Infections (CROI), poster, Boston, 2011年2月28日, 2011, Peer-reviewed

  
• P202 binds to retrovirus preintegration complex and attenuates retrovirus infection when fused with an inflammasome pyrin binding domain.

  Gee P; Koyanagi Y

  18th Conference on Retroviruses and Opportunistic Infections (CROI), poster, Boston, 2011年2月28日, 2011, Peer-reviewed

  
• Humanized mouse models for HIV-1 and EBV infection.

  Koyanagi Y

  2011 International Symposium on Infectious Disease and Signal Transduction, 台南, 台湾 2011年11月19日, 2011, Peer-reviewed

  
• Biochemical characterization of the HIV-1 restriction factor SAMHD1.

  Gee P; Okamoto S; Fukuhara M; Kanemura Y; Ebina H; Koyanagi Y

  12th Kumamoto AIDS Seminar-GCOE Joint International Symposium, 熊本, 2011年10月21 日, 2011, Peer-reviewed

  
• 急性感染期のHIV-1 増殖における制御性T 細胞とVpr の寄与

  佐藤佳; 三沢尚子; 佐藤賢文; 松岡雅雄; 伊藤守; 小柳義夫

  第25 回日本エイズ学会, WS1-006, 東京, 2011 年12 月2 日, 2011, Peer-reviewed

  
• APOBEC1 によるHSV-1 DNA のediting と抗ウイルス効果

  小柳義夫; Peter Gee; 川口寧; 北山裕子; 安藤良徳

  第18 回ヘルペス感染症フォーラム(JHIF) 札幌 2011 年8 月19 日, 2011, Peer-reviewed

  
• Mathematical modeling of wild type and Vpr -deleted HIV-1 infection in vitro

  Iwami S; Sato K; Koyanagi Y

  CBI/JSBi (情報計算化学生物学会/日本バイオインフォマティクス学会合同大会) 2011, 神戸, 2011 年11月8日, 2011, Peer-reviewed

  
• Integrase independent retroviral cDNA integration, which is indefensible with integrase inhibitor.

  Ebina H; Kanemura Y; Suzuki Y; Urata K; Koyanagi Y

  第6回研究所ネットワーク国際シンポジウム, 東京, 2011年6月9日, 2011, Peer-reviewed

  
• Intracellular anti-HIV factor

  Koyanagi Y

  International Symposium. Virus, host and diseases. Kyoto 2011年3月11日, 2011, Peer-reviewed

  
• DNA labeling system by peripheral blood of humanized mouse.

  Iwami S; Sato K; Misawa N; Kobayashi T; De Boer R; Koyanagi Y

  1st International Symposium on Innovative Mathematical Modeling, P-215, Tokyo, 2011年3月1日, 2011, Peer-reviewed

  
• ヒト化マウスモデルを用いたHIV-1 感染病態の解析

  佐藤佳; 三沢尚子; 小柳義夫

  第25 回近畿エイズ研究会, 京都,2011 年6 月18 日, 2011, Peer-reviewed

  
• Construction of labeling method for nucleosome-formed viral DNA.

  Ebina H; Urata K; Kanemura Y; Koyanagi Y

  第34 回日本分子生物学会年会, 横浜, 2011年12月13日, 2011, Peer-reviewed

  
• APOBEC1 -mediated editing and attenution of HSV-1 DNA implicates an antiviral role in neurons during encephalitis.

  Gee P; Ando Y; Kitayama H; Yammaoto S.P; Kanemura Y; Ebina H; Kawaguchi Y; Koyanagi Y

  第40回日本免疫学会, WS15-7, 幕張, 2011年11月27日, 2011, Peer-reviewed

  
• Depletion of regulatory T cells in acute phase may enforce HIV systemic infection.

  Koyanagi Y; Sato K

  12th Kumamoto AIDS Seminar-GCOE Joint International Symposium, 熊本, 2011年10月19日, 2011, Peer-reviewed

  
• 小さなウイルスがなぜ病気を起こすのか

  小柳義夫

  第10回みちのくウイルス塾, 仙台 2011 年7 月16 日, 2011, Peer-reviewed

  
• 細胞性HIV 抑制因子

  小柳義夫

  第2 回ナノバイオ創薬研究シンポジウム, 京都, 2011 年3 月5 日, 2011, Peer-reviewed

  
• HIV-1 Vpu相互作用および感受性に関与するヒトtetherin膜貫通領域のアミノ酸の同定(Identification of amino acids in the human tetherin transmembrane domain responsible for HIV-1 Vpu interaction and susceptibility)

  小林 朋子; 芳田 剛; 佐藤 佳; Gee Peter; 山元 誠司; 蝦名 博貴; 小柳 義夫

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• 細胞内DNA修復システムによるレトロウイルスcDNA組込み機能の代償

  蝦名 博貴; 鈴木 康嗣; 金村 優香; 津村 斐子; 小柳 義夫

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010, Peer-reviewed

  
• 【ウイルス病原性の実態-その時、宿主で何が起きているのか】 HIV-1のウイルス-宿主相互作用と新規治療薬の開発

  佐藤 佳; 小柳 義夫

  実験医学, Nov. 2010

  
• ヒトtetherin膜貫通ドメインはHIV-1 Vpu相互作用と感受性の責任部位である(Human tetherin transmembrane domain is responsible for HIV-1 Vpu interaction and susceptibility)

  小林 朋子; 大出 裕高; 佐藤 佳; Gee Peter; 山元 誠司; 蝦名 博貴; 佐藤 裕徳; 小柳 義夫

  日本エイズ学会誌, Nov. 2010

  
• HIV-1 Vpu counteracts the antiviral factor tetherin/BST-2 by binding it in lipid bilayer.

  Kobayashi T; Ode H; Sato H; Koyanagi Y

  The 16th East Asia Joint Conference on Biomedical Research, Taipei, Taiwan, 2010 年7 月1 日-2 日, Oct. 2010, Peer-reviewed

  
• G-to-A mutations in HIV-1 provirus by AP0BEC3 proteins contribute to abrogation of virus replication in humanized mice

  Sato K; Izumi T; Misawa N; Kobayashi T; Ito M; Takaori-Kondo A; Koyanagi Y

  第10 回あわじしま感染症・免疫フォーラム, 淡路島, 2010 年9 月7 日-10 日, 2010, Peer-reviewed

  
• DNA labeling system by peripheral blood of humanized mouse

  Iwami S; Sato K; Misawa N; Kobayashi T; de Boer RJ; Koyanagi Y

  the 2nd Synthetic Immunology Workshop, Kyoto, Japan, 2010 年12 月8 日, 2010, Peer-reviewed

  
• HIV 増殖制御宿主因子:BST-2 の機能と構造

  小柳義夫

  第12 回白馬シンポジウム, 徳島, 2010 年5 月14 日- 15 日, 2010, Peer-reviewed

  
• T cell and cytokine responses determine the fate of humanized mice with active Epstein-Barr virus infection

  Sato K; Misawa N; Nie C; Takahashi R; Ito M; Kuzushima K; Takada K; Koyanagi Y

  第7 回EBV 研究会, 札幌, 2010 年7 月9 日, 2010, Peer-reviewed

  
• A novel HIV-1 infection model using humanized mice

  Sato K; Koyanagi Y

  1st International Young Investigator Symposium, Kumamoto, Japan, 2010 年3 月4 日-5 日, 2010, Peer-reviewed

  
• Live cell-based mutagenesis studies reveals the st↓n ctural insights丘 )r human tetherin recognition by HIV-1 Vpu.

  Kobayashi T; Yoshida T; Sato K; Gee P. Ebina H; Koyanagi Y

  1 1th Kumamoto AIDS Seminar Global COE Joint International Symposium, Kumamoto, Japan, 2010 年10 月6 日-8 日, 2010, Peer-reviewed

  
• HIV-1 Vpu 相互作用に必須なtetherin/Bst-2 膜貫通領域アミノ酸の同定

  小林朋子; 芳田剛; 佐藤佳; Peter Gee; 山元誠司; 蝦名博貴; 小柳義夫

  第58 回日本ウイルス学会学術集会, 徳島,2010 年11 月7 日-9 日, 2010, Peer-reviewed

  
• ヒト化マウスを用いたEBV 関連血球貪食性リンパ組織球症モデルマウスの確立

  佐藤佳; 三沢尚子; Chuanyi Nie; 佐藤賢文; 松岡雅雄; 高橋玲; 伊藤守; 高田賢蔵; 小柳 義夫

  第58 回日本ウイルス学会学術集会, 徳島, 2010 年11 月7 日-9 日, 2010, Peer-reviewed

  
• HIV のアクセサリー蛋白質Vpu とその阻害蛋白テザリン

  小柳義夫; 小林朋子

  第58 回 日本ウイルス学会学術集会, 徳島,2010 年11 月7 日-9 日, 2010, Peer-reviewed

  
• Human tetherin transmembrane domain is responsible for HIV-1 Vpu interaction and susceptibility

  小林朋子; 大出裕高; 佐藤佳; Gee Peter; 山元誠司; 蝦名博貴; 佐藤裕徳; 小柳義夫

  第24 回日本エイズ学会学術集会, 東京, 2010 年11 月24 日-26 日, 2010, Peer-reviewed

  
• ヒト化マウス末梢血によるDNA ラペリング系の確立-動物実験-

  佐藤佳; 岩見真吾; 三沢尚子; 伊藤守; 小柳義夫

  第20 回日本数理生物学会大会, 札幌, 2010 年9 月13 日-16 日, 2010, Peer-reviewed

  
• HIV cDNA のインテグラーゼ非依存性組込みとウイルス複製

  蝦名博貴; 鈴木康嗣; 金村優香; 津村斐子; 小柳義夫

  第58 回日本ウイルス学会学術集会, 徳島,2010 年11 月7 日-9 日, 2010, Peer-reviewed

  
• テトラスパニンの生化学 その機能と疾患との関わりにおける新展開 HIV感染におけるテトラスパニンの意義

  小柳 義夫; 佐藤 佳

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• Mitochondria and membrane trafficking implication for HIV infection and pathogenesis

  Yoshio Koyanagi; Hiroko Kitayama; Kei Sato; Yukihito Ishizaka

  EUROPEAN JOURNAL OF MEDICAL RESEARCH, Aug. 2009, Peer-reviewed

  
• Epstein-Barr virus is productively replicated in humanized NOD/S CID/IL2gnull mice simulating severe complications observed in patients with fatal EBV infection

  Kei Sato; Naoko Misawa; Chuanyi Nie; Rei Takahashi; Mamoru Ito; Kiyotaka Kuzushima; Kenzo Takada; Yoshio Koyanagi

  第39 回日本免疫学会総会・学術集会、3-K-W63-7-0/P, 大阪、2009 年 12月2-4 日, 2009, Peer-reviewed

  
• レトロウイルスゲノムの組み込み機能を阻害する細胞性キナーゼの同定とその作用機序の解析

  鈴木康嗣; 小川加那子; 小柳義夫; 鈴木陽一

  第57 回日本ウイルス学会学術 集会、東京、2009 年10 月25-27 日, 2009, Peer-reviewed

  
• DNA 損傷部位へのインテグラーゼ非依存レトロウイルスDNA の遺伝子組込み機構

  蝦名博貴; 小柳義夫

  第57 回日本ウイルス学会学術集会、東京、2009 年25-27 日, 2009, Peer-reviewed

  
• レトロウイルスインテグラーゼ結合腫因子Huwe1の同定とHIV-1感染における役割

  山元誠司; 大川克也; 増田貴夫; 森川裕子; 小柳義夫; 鈴木陽一

  第57 回日本ウイルス学会学術集会、東京、2009 年10 月25-27 日, 2009, Peer-reviewed

  
• HIV-1 放出抑制分子BST-2 の解明

  小柳 義夫

  第50 回日本熱帯医学会大会、シンポジウム、 沖縄、2009 年10 月23-24 日, 2009, Peer-reviewed

  
• Characterization of HIV-1 pathogenesis and the infected cells in humanized mice

  Kei Sato; Chuanyi Nie; Naoko Misawa; Yuetsu Tanaka; Mamoru Ito; Yoshio Koyanagi

  16th Conference on Rctroviri ↓ses and Opportunistic Infections, D-179, Montreal, Canada, 2009 年 2 月8-11 日, 2009, Peer-reviewed

  
• シンポジウム「ヒト血液幹細胞移植マウスのウイルス病原性解析への利用」

  小柳義夫; 佐藤佳; 伊藤守

  第56 回日本実験動物学会, 大宮,2009 年5 月14- 16 日, 2009, Peer-reviewed

  
• HIV-1 インテグレース 相互作用因子Huwe1によるHIV-1 の感染抑制

  山元誠司; 大川克也; 増田貴夫; 森山裕子; 小柳義夫; 鈴木陽一

  第23 回日本エイズ学会学術集会・総会、名古屋、2009 年11 月26-28 日, 2009, Peer-reviewed

  
• テトラスパニンによるレトロウイルス感染制御

  小柳義夫; 佐藤佳

  第32 回日本分子生物学会年会、シンポジウム、横浜、2009 年12 月9-12 日, 2009, Peer-reviewed

  
• HIV 感染におけるテトラスパニンの意義

  小柳義夫; 佐藤佳

  第82 回日本生化学会大会, シンポジウム, 神戸,2009 年10 月21-24 日, 2009, Peer-reviewed

  
• Bst-2 とHIV-1 Vpu の相互作用メカニズムの解析

  小林朋子; 芳田剛; 佐藤佳; Peter Gee; 蝦名博貴; 小柳義夫

  第57回日本ウイルス学会学術集会、東京、2009 年10 月25 -27 日, 2009, Peer-reviewed

  
• HIV and EBV infection model using humanized

  Koyanagi Y

  Workshop Taiwan-Japan“Host-Pathogen Interaction", Kyoto ,2009 年 11 月 26日, 2009, Peer-reviewed

  
• Rho GTPase family によるHIV-1 複製抑制

  渡部匡史; 鈴木陽一; 宮澤正顯; 小柳義夫

  第57 回日本ウイルス学会学術集会、東京、2009 年10 月25-27 日, 2009, Peer-reviewed

  
• 異種動物細胞株を用いたヒトBST-2/Tetherin の 機能比較研究

  佐藤佳; 山元誠司; 三沢尚子; 小柳義夫

  第23 回日本エイズ学会学術集会、062-335 、名古屋、2009 年11 月26 -28 日, 2009, Peer-reviewed

  
• 致死性EBV 感染症モデルマウスの作製と病態解析

  佐藤佳; 三沢尚子; Chuanyi Nie; 高橋玲; 伊藤守; 葛島清隆; 高田賢藏; 小柳義夫

  第57 回日本ウイルス学会学術集会、 3WSA5 、東京、2009 年10 月25-27 日, 2009, Peer-reviewed

  
• Small GTPase Rac2 によるHIV-1 産生抑制

  渡部匡史; 鈴木陽一; 宮澤正顯; 小柳義夫

  第22 回日本エイズ学会学術集会総会、大阪、１１月26-28 日,2008, 26 Nov. 2008, Peer-reviewed

  
• HIV-1 pathogenesis: productive infection in CD4+ effecter memory T lymphocytes and CD4+ depletion in humanized mice

  Koyanagi Y

  第11 回京都大学国際シンポジウム, 上海, 2008., Sep. 2008, Invited

  
• HIV and AIDS

  Koyanagi, Y

  日中数理生物学コロキュームシンポジウム, 岡山, 2008, Aug. 2008, Peer-reviewed

  
• Characterization of pathogenesis and productive infection of HIV-1 in humanized mice.

  Sato K; Nie C; Misawa N; Tanaka Y; Ito M; Koyanagi Y

  The 8th Awaji Symposium, Awaji, 2008., 2008, Peer-reviewed

  
• TAP-MS 法によるインチグレース結合因子Huwel の同定とその析

  山元 司; 大川克也; 小川加 子; 増田 夫; 森川裕子; 小柳義夫; 木 一

  第22 回日本エイズ学会、2008, 2008, Peer-reviewed

  
• HIV-1 複製制御におけるSmall GTPase Rac2 の機能析

  渡 匡史; 木 一; 宮澤正; 小柳義夫

  第22 回日本エイズ学会、2008, 2008, Peer-reviewed

  
• レンチウイルスベクターを用いた抗HIV 因 子のスクリーニングとその析

  小林朋子; 芳田剛, 淳; 小柳義夫

  第22 回日本エイズ学会、2008, 2008, Peer-reviewed

  
• ウイルスに対する海組織の脆弱性にする研究

  安藤良徳; 北山裕子; 小柳義夫

  第 22 回日本エイズ学会、2008, 2008, Peer-reviewed

  
• Small GTPase Rac2 によるHIV-1 増殖制御

  渡 匡史; 木 一; 宮澤正; 小柳義夫

  第56回日本ウイルス学会, 岡山, 2008, 2008, Peer-reviewed

  
• EBV 感染モデルマウスの確 立と活性化CD8 ＋細胞の導

  佐藤佳; 三沢尚子; Chuanyi Nie; 橋玲; 伊藤守; 小柳義夫

  第38 回日本免疫学会総会、2008, 2008, Peer-reviewed

  
• インターフェロンオメガ1によるHIV-1感染抑制機構の析

  篠田康彦; 木 一; 田中勇悦; 小柳義夫

  第22 回日本エイズ学会、2008, 2008, Peer-reviewed

  
• ヒト化マウスにおける HIV-1 感染指向性と持続感染細胞の同定

  佐藤佳; Chuanyi Nie; 三沢尚子; 田中勇悦; 伊藤守; 小柳義夫

  第22 回日本エイズ学会、2008, 2008, Peer-reviewed

  
• VRK induces dysfunction of the MoMLV PIC through phosphorylation of BAF.

  Suzuki Y; Ogawa K; Koyanagi Y; Suzuki Y

  3rd International Conference on Retroviral Integrase, Woods Hole, USA. September 14-18, 2008, 2008, Peer-reviewed

  
• 細胞性キナーゼVRK1 によるレトロウイ ルスインテグレーション機能の害とその分子メカニズム

  木康嗣; 小川加 子; 小柳義夫; 木 一

  第56 回日本ウイルス学会、岡山、2008, 2008, Peer-reviewed

  
• In vivo model for primary HTLV-I infection of human lymphocytes

  Paola Miyazato; Jun-ichirou Yasunaga; Yuko Taniguchi; Yoshio Koyanagi; Hiroaki Mitsuya; Masao Matsuoka

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Apr. 2007

  
• Foundation and Recent Progresses in Rctrovirus Research

  Koyanagi Y

  Awaji symposium, Awaji, 2007., 2007, Peer-reviewed

  
• Tetraspanin on HIV-1 virions inhibits its infection.

  Sato K; Aoki J; Daikoku E; Sano K; Tanaka Y; Koyanagi Y

  14th Conference on Rctroviruses and Opportunistic Infections, Los Angeles, 2007., 2007, Peer-reviewed

  
• Non-stimulated PBMC において増殖するHIV-1の分離と その性状の解析

  鈴木陽一; 武内寛明; 小柳義夫

  第21回日本エイズ学会学術集会・総会, 広島, 2007 年11 月28-30 日, 2007, Peer-reviewed

  
• HIV-1 の粒子産生過程におけるRal GTPase の機能解析

  佐藤佳; 山元誠司; 小柳義夫

  第 30 回日本分子生物学会年会・第80 回日本生化学会大会合同大会、横浜、2007, 2007, Peer-reviewed

  
• 受容体分子の表面発現を輸送小胞レベルで調節する機構;HIV のコレセプター分子の細胞質膜発現を調節する

  芳田剛; 河野祐治; 安藤良徳; 佐藤佳; 駒野淳; 三浦義治; 田中勇悦; 小柳 義夫

  第30 回日本分子生物学会年会・第80 回日本生化学会大会合同大会、横浜、2007, 2007, Peer-reviewed

  
• HSV-1 感染による中枢神経組織障害 の経時的解析

  安藤良徳; 北山裕子; 三浦義治; 川口寧; 小柳義夫

  第55 回日本ウイルス学会、札幌、2007, 2007, Peer-reviewed

  
• HIV-1 感染ヒト造血細胞移植マウス内に維持される長期高ウイルス血症

  小柳義夫; 三沢尚子; 北山裕子; 佐藤佳; 渡部匡史; Johnny Chuanyi Nie; 伊藤守

  第55 回日本ウイル ス学会、札幌、2007, 2007, Peer-reviewed

  
• CXCR4 トラフィキング過程の可視化と遺伝子導入による HIV-1 感染阻害

  芳田剛; 安藤良徳; 小柳義夫

  第55 回日本ウイルス学会、札幌、2007, 2007, Peer-reviewed

  
• HIV-1 viral protein R inhibits axon formation that leads to impaired repairment of synaptodendritic connections through induction of mitochondrial dysfunction. A lentiviral \ncDNA library employing lambda recombination used to clone an inhibitor of HIV-1-

  Koyanagi Y

  14th East Asia symposium, Tokyo, 2007., 2007, Peer-reviewed

  
• HIV 感染による認知障 害機構:Vpr によるミトコンドリア機能障害による神経前駆細胞分化抑制

  北山裕子; 安藤良徳; 三浦義治; 星野重樹; 石坂幸入; 小柳義夫

  第21 回日 本エイズ学会、広島、2007., 2007, Peer-reviewed

  
• インターフェロンオメガ１による HIV-1感染抑制

  篠田康彦; 田中勇悦; 鈴木陽一; 三浦義治; 小柳義夫

  第55 回日本ウイルス学会, 札幌, 2007 年10月21-23 日, 2007, Peer-reviewed

  
• HIV-1 Vpr 誘導性ミトコンドリア機能障害による神経細胞軸索伸長の阻害

  北山裕子; 安藤良徳; 三浦義治; 星野重樹; 石坂幸入; 小柳義夫

  第55 回日本ウイルス学会、札幌、 2007., 2007, Peer-reviewed

  
• Tandem affinity purification 法によるレトロウイル スキャプシド結合腫因子の探索

  山元誠司; 小川加那子; 小柳義夫; 鈴木陽二

  分子生物学フォーラム. 名古屋. 2006., 2006, Peer-reviewed

  
• fflV-1 感染マクロファージに よる神経細胞の軸索伸張障害メカニズムの解析

  北山裕子; 三浦義治; 安藤良徳; 星野重樹; 石坂幸人; 小柳義夫

  第54 回日本ウイルス学会、名古屋、2006., 2006, Peer-reviewed

  
• 抗HSV 作用を有する脳内宿主因子の解 析一潜伏感染への関与

  北山裕子; 三浦義治; 安藤良徳; 川口寧; 小柳義夫

  第21 回ヘルペス研究会, 白川郷, 2006 年, 2006, Peer-reviewed

  
• The axon outgrowth of neuron was inhibited by HIV-1 infected macrophage.

  Kitayama H; Miura Y; Ando Y; Hoshino S; Ishizaka Y; Koyanagi Y

  13th East Asia Joint Symposium on Biomedical Research, Seoul, 2006., 2006, Peer-reviewed

  
• エイズ脳症における神経細 胞の軸索伸張障害メカニズムの解析

  北山裕子; 三浦義治; 安藤良徳; 星野重樹; 石坂幸入; 小柳義夫

  近畿エイズ研究会, 大阪, 2006., 2006, Peer-reviewed

  
• HSV-1 に感染したラット脳海馬 スライス培養系における神経系細胞の解析

  安藤良徳; 三浦義治; 北山裕子; 岡田広司; 川口寧; 小柳義夫

  第54 回日本ウイルス学会、名古屋、2006., 2006, Peer-reviewed

  
• HIV-1 Vpr のウイルス再活性における役割

  星野重樹; 孫賓蓮; 古西満; 小柳義夫; 石坂幸入

  第 54 回日本ウイルス学会, 名古屋, 2006, 2006, Peer-reviewed

  
• HIV-1 感染抑制因子の単離.

  芳田剛; 小柳義夫

  第9 回白馬シンポジュウム2006 in 京都, 2006, Peer-reviewed

  
• 宿主因子の過剰発現によるHIV-1 Env タンパク質のビリオンヘの取り込み抑制

  佐藤佳; 青木淳; 大黒恵理子; 佐野浩一; 田中勇悦; 小柳義夫

  近畿エイズ研究会, 大阪, 2006., 2006, Peer-reviewed

  
• 新規HIV 感染小動物モデルの開発: ヒト造血細胞移植 SCID マウス

  小柳義夫; 三沢尚子; 佐藤佳; 伊藤守

  第20 回日本エイズ学会、東京、2006, 2006, Peer-reviewed

  
• テトラスパニン分子の過剰発現 によるHIV-1 の感染価抑制.

  佐藤佳; 青木淳; 大黒恵理子; 佐野浩二田中勇悦; 小柳義夫

  第54 回日本ウイルス学会、名古屋、2006., 2006, Peer-reviewed

  
• HIV 感染モデル動物としてのヒト造血細胞移植SCID マ ウスの開発

  小柳義夫; 三沢尚子; 佐藤佳; 伊藤守

  第54 回日本ウイルス学会、名古屋、2006, 2006, Peer-reviewed

  
• CCR5 指向性HIV-1 感染防御因子(CD4 因子) 産生細胞株に特異的な発現遺伝子の探索

  篠田康彦; 田中勇悦; 三浦義治; 鈴木陽一; 小柳義夫

  第54 回日本ウイルス学会, 名古屋, 2006., 2006, Peer-reviewed

  
• HIV と宿主の相制: 感染モデルからの解析

  小柳義夫

  第9 回白馬シンポジュウム2006 in 京都, 2006, Peer-reviewed

  
• Stem cell neurovirology:comparative analyses of neural stem cells in HIV-1 and HSV-1 infection.

  Miura Y; Andou Y; Kitayama H; Koyanagi Y

  第29 回日本神経科学大会, 京都., 2006, Peer-reviewed

  
• 融合蛋白質標識法を用いた細胞膜受容体分子CXCR4 の細胞内ト ラフィッキング解析

  安藤良徳; 芳田剛; 小柳義夫

  分子生物学フォーラム、名古屋、2006, 2006, Peer-reviewed

  
• CXCR4 の細胞質膜移 行を制御する分子

  芳田剛; 河野祐治; 佐藤佳; 安藤良徳; 三浦義治; 田中勇悦; 小柳義夫

  分子生物学フォーラム、名古屋. 2006., 2006, Peer-reviewed

  
• 原発性感染細胞を持つNOGマウスにおけるHTLV-I感染における初期事象の研究(Study of early events in HTLV-I infection in NOG mice with primarily infected-cells)

  Miyazato Paola; 安永 純一朗; 谷口 裕子; 小柳 義夫; 満屋 裕明; 松岡 雅雄

  日本血液学会・日本臨床血液学会総会プログラム・抄録集, Sep. 2005

  
• 免疫不全マウスを用いたHTLV-I初期感染モデルの確立(An in vivo model for primary infection with HTLV-I)

  パオラ・ミヤザト; 安永 純一朗; 小柳 義夫; 満屋 裕明; 松岡 雅雄

  日本癌学会総会記事, Sep. 2005

  
• テトラスパニン分子によるHIV-1 粒 子の感染性抑制

  青木淳; 佐藤佳; 大黒恵理子; 佐野浩一; 小柳義夫

  第19 回日本エイズ学会、熊本、2005, 2005, Peer-reviewed

  
• 中枢神経系組織内において抗HSV 効果を発揮 する宿主因子の網羅的解析

  北山裕子; 三浦義治; 川口寧; 小柳義夫

  第２０回ヘルペスウイルス研究会、名古屋、2005, 2005, Peer-reviewed

  
• HIV 感染マクロファージによる中枢神経系未分化細胞群の障害

  三浦義治; 北山裕子; 小柳義夫

  第１０回日本感染症学会、東京、2005, 2005, Peer-reviewed

  
• HIV 脳症における中枢神経系未分化細胞群関与の検討

  三浦義治; 北山裕子; 小柳義夫

  第19 回日本エイズ学会、熊本、2005, 2005, Peer-reviewed

  
• 免疫不全マウスを用いた HTLV-I 初期感染モデルの確立

  Miyazato Paola; 安永純一朗; 小柳義夫; 満屋裕明; 松岡雅雄

  第64 回日本癌学会学術総会、札幌、2005 年9 月14-16 日, 2005, Peer-reviewed

  
• 薬剤誘導性発現レンチウイルスベクターの開発

  篠田康彦; 稗田訓子; 小柳義夫

  第53 回日本ウイルス学会、横浜、2005, 2005, Peer-reviewed

  
• 特定の細胞膜表面分子に対 する細胞膜移行阻止因子の単離：CXCR4 発現阻止因子

  芳田剛; 河野祐治; 青木淳; 三浦義治; 田中勇悦; 小柳義夫

  第28 回日本分子生物学会、 福岡、2005, 2005, Peer-reviewed

  
• 中枢神経組織内における抗HSV 因子の探索

  北山裕子; 三浦義治; 川口寧; 小柳義夫

  第53 回日本ウイルス学会、横浜、2005, 2005, Peer-reviewed

  
• 神経幹細胞は単純ヘルペスウイルス１型感染細胞として重要である

  三浦義治; 青木淳; 北山裕子; 佐野浩一; 川口寧; 小柳義夫

  第１０回日本感染症学会、東京、2005, 2005, Peer-reviewed

  
• がん細胞転移抑制性レンチウイルスベクターの開 発

  佐藤佳; 青木淳; 北山裕子; 小柳義夫

  第53 回日本ウイルス学会、横浜、2005, 2005, Peer-reviewed

  
• 生細胞における CXCR4 分子のイメージング解析

  安藤良徳; 芳田剛; 小柳義夫

  第53 回 日本ウイルス学会、横浜、2005, 2005, Peer-reviewed

  
• 抗HIV 因子の単離

  芳田剛; 河野祐治; 青木淳; 三浦義治; 田中勇悦; 小柳義夫

  CXCR4 細胞膜移行阻害分子の同定．第53 回日本ウイルス学会、横浜、2005, 2005, Peer-reviewed

  
• CD63 過剰発現によるHIV-1 粒子の感染性抑制

  青木淳; 佐藤佳; 佐野浩一; 大黒恵理子; 小柳義夫

  第53 回日本ウイルス学会、横浜、2005, 2005, Peer-reviewed

  
• CXCR4 を標的としたsiRNA 発現レンチウイルスベクターを用いた悪 性腫瘍の遺伝子治療

  青木淳; 小柳義夫

  第64 回日本癌学会、札幌、2005, 2005, Peer-reviewed

  
• HIV-1 潜伏感染細胞からのウイルス 再産生におけるVprの機能

  星野重樹; 志村まり; 田口崇; 小柳義夫; 石坂幸人

  第28 回日本分子生物学会、福岡、2005, 2005, Peer-reviewed

  
• 神経幹細胞における単純ヘ ルペスウイルス感染動態の解析

  三浦義治; 青木淳; 北山裕子; 佐野浩一; 川口寧; 小柳義夫

  第２０回ヘルペスウイルス研究会、名古屋、2005, 2005, Peer-reviewed

  
• 実験小動物を用いたエイ ズ脳症の研究

  三浦義治; 北山裕子; 三沢尚子; 岡田広司; 青木淳; 小柳義夫

  第１９回近畿エイズ研究会学術集会、京都, 2005, Peer-reviewed

  
• HIV encephalopathy

  Yoshiharu Miura; Yoshio Koyanagi

  Clinical Neurology, Nov. 2005, Peer-reviewed

  
• A new murine model of HIV-associated encephalopathy

  Yoshiharu Miura; Yoshio Koyanagi; Hidehiro Mizusawa

  Brain and Nerve, Apr. 2004

  
• Virus replication begins in Langerhans cells and not in dermal dendritic cells during transmission of HIV from skin emigrants to T cells

  T Kawamura; T Iwamoto; Y Koyanagi; M Ito; A Blauvelt; S Shimada

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Mar. 2004

  
• NOG(NOD/Shi-scid,γcnu11)マウス ヒト細胞高生着性を利用したHIV-1,HTLV-1感染症モデル

  伊藤 守; 小柳 義夫; 寺嶋 一夫; 山本 直樹; 中畑 龍俊; 上山 義人; 玉置 憲一; 野村 達次

  日本疾患モデル学会記録, Jul. 2003

  
• 卵巣移植の免疫 (産婦人科治療)

  寺田幸弘; 佐藤由美; 宇都宮裕貴; 村上節; 八重樫伸生; 岡村州博; 小柳義夫

  産婦人科治療, Dec. 2002

  
• NOG(NOD/Shi-scid,γcnull)マウスでのヒト細胞高生着性を用いたヒト疾患モデルへの応用

  伊藤 守; 小柳 義夫; 寺島 一夫; 山本 直樹; 中畑 龍俊; 上山 義人; 玉置 憲一; 野村 達次

  日本疾患モデル学会記録, Oct. 2002

  
• Immunological and virological effects of interferon-alpha therapy in HTLV-I-associated myelopathy/tropical spastic paraparesis

  J Feng; T Misu; K Fujihara; N Misawa; Y Koyanagi; Y Shiga; S Sato; S Takase; T Konosu; H Saito; Y Itoyama

  ANNALS OF NEUROLOGY, Sep. 2002

  
• Trail mediates neuronal apoptosis in a murine model of HIV encephalopathy.

  Y Miura; N Yamamoto; H Yagita; Y Koyanagi; H Mizusawa

  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, May 2002

  
• Inhibitory mechanism of the CXCR4 antagonist T22 against human immunodeficiency virus type 1 infection (vol 73, pg 7489, 1999)

  T Murakami; TY Zhang; Y Koyanagi; Y Tanaka; J Kim; Y Suzuki; S Minoguchi; H Tamamura; M Waki; A Matsumoto; N Fujii; H Shida; JA Hoxie; SC Peiper; N Yamamoto

  JOURNAL OF VIROLOGY, Jan. 2002

  
• 新たに開発したNOD/Shi-scid,γc nullマウスの移入ヒト細胞の高生着性とその免疫学的特性について

  伊藤 守; 小林 喜美男; 川幡 まりこ; 日置 恭司; 鈴江 一友; 小柳 義夫; 菅村 和夫; 平松 英文; 平家 俊男; 中畑 龍俊

  日本免疫学会総会・学術集会記録, Dec. 2001

  
• 感染と増殖 エイズ脳症モデルマウスの確立と神経細胞死のシグナルの解明

  小柳 義夫; 三浦 義治; 山本 直樹; 水澤 英一; 八木田 秀雄

  日本エイズ学会誌, Nov. 2001

  
• 新たに育成されたNOD/Shi‐scid,IL‐2RγKOマウスが示す移入ヒト細胞に対する高生着生

  川幡まりこ; 小林喜美男; 日置恭司; 小柳義夫; 中畑龍俊; 伊藤守

  日本実験動物学会総会講演要旨集, 2001

  
• ダンベルオリゴヌクレオチドによるHIV‐1プロウイルスDNA転写阻害効果

  TAKEUCHI HIROAKI; HOSOYA TAKESHI; YAMAKAWA HIDEFUMI; TAKAI KAZUYUKI; KOYANAGI YOSHIO; YAMAMOTO NAOKI; TAKAKU HIROSHI

  アンチセンスシンポジウム講演要旨集, Nov. 1998

  
• HIV‐1 gag領域に対する28merアンチセンスオリゴヌクレオチドの抗HIV‐1活性

  KUROSAKI NAOKO; TAKEUCHI HIROAKI; KOYANAGI YOSHIO; MISAWA NAOKO; TAKAI KAZUYUKI; YAMAMOTO NAOKI; TAKAKU HIROSHI

  アンチセンスシンポジウム講演要旨集, Nov. 1998

  
• HIVの病態生化学と新しい分子治療 ホールドバック型三重鎖核酸の抗HIV活性

  平藤 隆士; 塚原 智; 高井 和幸; 小柳 義夫; 山本 直樹; 高久 洋

  生化学, Aug. 1998

  
• Suppression of HIV-1 expression by tRNA promoter-driven hammerhead ribozymes.

  KUROSAKI NAOKO; KOYANAGI YOSHIO; SUZUKI YOICHI; TAKEUCHI HIROAKI; KANBARA KENJI; HABU YUICHIRO; TAKAI KAZUYUKI; TAKAKU HIROSHI; YAMAMOTO NAOKI

  アンチセンスシンポジウム講演要旨集, Nov. 1997

  
• Inhibition of HIV-1 replication by oligonucleotides forming triple-helices targeted to polypurine tract.

  TSUKAHARA SATORU; SUZUKI ATSUSHI; GOTO YUTA; INAGAWA TAKAFUMI; TAKEUCHI HIROAKI; TAKAI KAZUYUKI; KOYANAGI YOSHIO; YAMAMOTO NAOKI; TAKAKU HIROSHI

  アンチセンスシンポジウム講演要旨集, 1996

  
• SEQUENCE HETEROGENEITY OF HUMAN T-LYMPHOTROPIC VIRUS TYPE I(HTLV-I) PROVIRAL DNA IN THE CENTRAL-NERVOUS-SYSTEM OF PATIENTS WITH HTLV-I-ASSOCIATED MYELOPATHY AND THE POSSIBLE EXPRESSION OF THE MUTANT PX GENE-PRODUCTS IN-VIVO

  J KIRA; J SUZUKI; E BABA; Y KOYANAGI; N YAMAMOTO; T KOBAYASHI

  ANNALS OF NEUROLOGY, Aug. 1995

  
• REGULATION OF HIV EXPRESSION IN PRIMARY MONONUCLEAR PHAGOCYTES

  ISY CHEN; WA OBRIEN; Y KOYANAGI; M YIP

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Jan. 1990

  
• 単純ヘルペスウイルス1 型に感染したneurosphere 形成培養系の解析

  三浦義治; 安藤良徳; 北山裕子; 佐野浩一; 川口寧; 小柳義夫

  第21 回ヘルペス研究会, 白川郷, Peer-reviewed

  
• ラット脳海馬スライス培養系を用いたエイズ脳症の病態解析

  北山裕子; 三浦義治; 小柳義夫

  第１９回近畿エイズ研究会学術集会、京都、2005, Peer-reviewed

  
• HIV-1 感染ヒト造血マウス

  小柳義夫

  第31 回阿蘇シンポジウム、熊本, Peer-reviewed

  

Presentations

• Molecular dissection of HIV infection event

  KOYANAGI Yoshio; SATO Kei

  2 nd JSPS Core to Core International Symposium, subtitled (Infection Immunity) x Evolution,, 06 Mar. 2019, Invited

  
• HIV-1 pathogenesis study using humanized mice

  KOYANAGI Yoshio; SATO Kei

  30th International Workshop on Retroviral Pathogenesis, 09 Oct. 2018, Invited

  
• エイズウイルス研究の始まりと現在, HIVカンファレンス

  小柳 義夫

  HIVカンファレンス, 08 Dec. 2017, Invited

  
• Regional prevalence of HIV-1 adjustment to APOBEC3H variants revealed from wet/dry investigations

  KOYANAGI Yoshio; SATO Kei

  第18回熊本エイズセミナー, 30 Oct. 2017, Invited

  
• エイズウイルスの過去と現在

  小柳 義夫

  第12回ウイルス・再生医科学研究所公開講演会, 15 Jul. 2017

  
• レトロウイルスと宿主の相克

  小柳 義夫

  大阪大学微研アドバンストセミナー, 14 Apr. 2017, Invited

  
• HIVと宿主制御因子の相互作用解析に基づくウイルス感染拡大様式の解明

  小柳 義夫

  北海道大学遺伝子病制御研究所「感染、免疫、がん、炎症」研究集会, 14 Mar. 2017, Invited

  

Books and Other Publications

• Humanized Mice for HIV Research

  Larisa Y. Poluektova; J. Victor; Garcia-Martinez; Yoshio Koyanagi; Markus G. Manz; Andrew M. Tager, Joint editor

  Springer, Feb. 2015, Not refereed

  Find Kyoto University's collection of books :

  

Works

• 新しいキメラマウスモデルにおけるエイズの発症機序とその制御に関する研究

  From 1996, To 2000

  

Awards

• 25 Nov. 2017

  The Japanese Society for AIDS Research, CMIC prize

External funds: Kakenhi

• HIV-1産生の不均一性を規定する原理の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49060:Virology-related

  Kyoto University

  小柳 義夫

  From 01 Apr. 2021, To 31 Mar. 2024, Declined

  ヒト化マウス;HIV;１細胞RNAシークエンス;バイオインフォマティクス;インテグレーション;CD4+ T細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02737/
• Investigation of the molecular mechanism of AIDS virus evolution

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kei Sato

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  システムウイルス学;HIV-1;チンパンジー;ヒト化マウス;適応進化;HIV;SIV;進化ウイルス学;エイズ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K07166/
• Genome editing tool for gene therapy in human hematopoietic stem cells

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Yoshio Koyanagi

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  ゲノム編集;遺伝子治療;CRISPR;TALEN;血液幹細胞;CRISPR法;TALEN法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670168/
• Analysis of viral infection and innate immune response using humanized mice

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshio KOYANAGI

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  ヒト化マウス;ウイルス制御因子;HIV;tetherin;APOBEC3;アクセサリ蛋白質;Vif;シチジン脱アミノ酵素;Vpr;制御性T細胞;Treg;HTLV

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390112/
• Mathematical modeling and analysis of virus-host interaction

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The Graduate University for Advanced Studies

  Akira Sasaki

  From 28 Jun. 2012, To 31 Mar. 2017, Project Closed

  ウイルスと宿主の共進化;ヒト化マウス;APOBEC;Vif;cell-to-cell感染;マルチトロピズム;ネットワーク理論;時系列解析;A3H多型;Vif多型;感染実験;R0中心性;感染部位ネットワーク;トロピズム;HIV;宿主内感染ダイナミクス;ウイルス増殖;進化;数理モデル;免疫不全ウイルス;APOBEC3G;共進化;エラー・カタストロフ;hyper-mutation;ワード分布;擬種動態;基本再生産数;ウイルス;免疫;感染過程;APOBECK3G;エラーカタストロフ;抗原連続変異

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24115008/
• Molecular basis of host cell competency in virus infection

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  University of Tsukuba

  Kyosuke NAGATA

  From 28 Jun. 2012, To 31 Mar. 2017, Project Closed

  ウイルス;宿主因子;コンピテンシー;自然免疫;構造解析;数理科学解析;オミックス解析;感染コンピテンシー;病原性発現;宿主特異性;許容性;共同研究インターンシップ;感染防御;感染症;数理科学;プロテオミクス;ポストゲノム

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-24115001/
• Study of novel HIV restriction factors

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Yoshio KOYANAGI

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  AIDS;HIV;restriction factor;SAMHD1;Vpx;マクロファージ;HSV;nucleotidase;単球

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659229/
• Study on in vivo function of APOBEC3 and its effect on pathophysiology of HIV-1 infection

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  AKIFUMI TAKAORI

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  個体;遺伝子;ウイルス;進化;宿主因子;内在性免疫;変異;ゲノム;感染症;免疫;感染防御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390110/
• Global stability for the system of ordinary differential equations with time delays and its applications to medicine

  Grant-in-Aid for Scientific Research (C)

  Aoyama Gakuin University;Shizuoka University

  Takeuchi YASUHIRO

  From 01 Apr. 2010, To 31 Mar. 2014, Project Closed

  数理医学モデル;時間遅れ;大域的安定性;数理モデル;応用数学;解析学;関数方程式論;生態学;安定性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22540122/
• Development of experimentation systems related to personalized medicine using humanized NOG mice

  Grant-in-Aid for Scientific Research (S)

  Central Institute for Experimental Animals

  Mamoru ITO

  From 01 Apr. 2010, To 31 Mar. 2015, Project Closed

  ヒト化マウス;免疫不全マウス;実験動物学;個別医療;実験動物;個別化医療;免疫不全動物;ヒト化モデル;個別衣料

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22220007/
• Functional analysis of cellular membrane proteins for generation of viral envelope and transmission

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshio KOYANAGI

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  BST2;HIV;エンベロープ;テザリン;宿主因子;BiFC;アクセサリー蛋白質;膜蛋白質;BST-2;Vpu;Bst-2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390137/
• Analysis of retroviral nucleoprotein complex that executes viral DNA integration into host genome

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Youichi SUZUKI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  レトロウイルス;高分子複合体;インテグレーション;ラミナ関連蛋白質;ゲノム組み込み;細胞性因子;BAF;LAP2α;抑制機構;高分子複合体形成;VRK1;Huwe1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790338/
• Study of replication, life cycle, and pathogenesis of retrovirus (HIV)

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Yoshio KOYANAGI

  From 01 Apr. 2006, To 31 Mar. 2011, Project Closed

  HIV;動物モデル;テトラスパニン;テザリン;中和抗体;SIV;CTL;宿主制御因子;ヒト化マウス;エイズワクチン;宿主因子;CD4陽性ヘルパーT細胞;CXCR4;ヒト化マウ;MHC;エイズ;ウイルス抑制;CD63;ワクチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18073008/
• Support for Research Techniques and Materials

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo;Microbial Chemistry Research Foundation

  Akio NOMOTO

  From 01 Apr. 2006, To 31 Mar. 2011, Project Closed

  感染症;ウイルス;細菌;寄生虫;免疫学;微生物;免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18073006/
• Matrix of Infection Phenomena

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Microbial Chemistry Research Foundation;The University of Tokyo

  Akio NOMOTO

  From 01 Apr. 2006, To 31 Mar. 2012, Project Closed

  感染症;ウイルス;細菌;寄生虫;免疫;微生物;免疫学

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-18073005/
• レンチウイルスベクターによる新規癌転移遺伝子の網羅的探索とその抑制法の開発研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  小柳 義夫

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  乳がん細胞;レンチウイルスベクター;がん転移;HIV;CXCR4;CD63

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17016040/
• Investigation of tissue destruction signals on viral encephalitis

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yoshio KOYANAGI

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  HIV;HSV;Encephalitis;Brain;hippocampal slice culture;Neuronal differentiation;Macrophage;Microaray;脳症;神経細胞破壊シグナル;マクロファージ;グリア細胞;海馬スライス培養;HIV脳症;単純ヘルペス脳炎, HIV;HSV;Encephalitis;Brain;hippocampal slice culture;Neuronal differentiation;Macrophage;Microaray

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390112/
• HIV抑制因子の遺伝子導入による新たな治療法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  小柳 義夫

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  HIV;レンチウイルスベクター;CXCR4;CD63;Env蛋白質;tetrasanin;ウイルスベクター;CD14;cDNAライブラリ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16017211/
• エフェクター前駆細胞へのHIV抑制因子の遺伝子導入による新たな治療法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tohoku University

  小柳 義夫

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  HIV;レンチウイルスベクター;エイズ;cDNAライブラリ;siRNA;CPE;CXCR4;CD14

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15019008/
• Basic Research for AIDS control

  特定領域研究

  Biological Sciences

  Kyoto University

  Takashi UCHIYAMA

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  HIV-1;宿主因子;病態;免疫;制御;ケモカイン;ケモカイン受容体;エイズ;HIV複製;コレセプター;抗HIV免疫;抗HIV剤;薬剤耐性, HIV-1;Host Factors;Pathophysiology;Immune response;AIDS Control;Chemokine;Chemokine Receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10180103/
• The studies on the practical application of NOD-sc/d, yc null mice allowing an efficient transplantation of human cells, to human disease models

  Grant-in-Aid for Scientific Research (B)

  Central Institute for Experimental Animals

  Mamoru ITO

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  実験動物;NOD-scid, γKOマウス;免疫不全;異種移植;CD34+細胞;HIV-1;HTLV-1;NOD-scid,γKOマウス, experimental animals;NOD-scid. γc null mice;Immunodeficiency;Xenotransplantation;CD34+ stem cells;HIV-1;HTLV-1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13558100/
• Reconstitution of human lymphoid tissue in mouse and its application

  Grant-in-Aid for Scientific Research (C)

  Tohoku University Graduate School of Medicine

  Yoshio KOYANAGI

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  SCIDマウス;リンパ臓器;CD4陽性T細胞;アポトーシス;HIV;TRAIL;FasL;ケモカイン;NOD-SCIDマウス;移植マウス;CD4陽性T細胞破壊;脾臓;リンパ節構造, SCID mouse;lymphoid organ;CD4+ T cell;Apoptosis;HIV;TRAIL;FasL;chemokine

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680806/
• Lymphocyte deficient mice as hosts for xenograft of human cells

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Masataka NAKAMURA

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  免疫不全;疾患モデル;コモンγ鎖;RAG1・RAG2;ノックアウトマウス;ヒト癌細胞;NK細胞, immunodeficiency;animal model;common γchain;RAG1・RAG2;knock-out mouse;human cancer

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10559007/
• Induction of chronic inflammatory myelopathy in rats infected with recombinant HTLV-I

  Grant-in-Aid for Scientific Research (B)

  KYUSHU UNIVERSITY

  Jun-ichi KIRA

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  HTLV-I;HAM;脊髄症;関節炎;動物モデル;MT2;感染性cDNAクローン;キメラ;HTLV-1;感染症cDNAクローン;ラット;クローン;サイトカイン;Th1;Th2バランス;中枢神経;末梢神経, HTLV-I;HAM;Myelopathy;Arthritis;animal models;MT-2;infectious cDNA clone

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10557062/
• Basic Research for AIDS control A02 ; Pathophysiology and immunology of HIV-1 infection

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  KYOTO UNIVERSITY

  Takashi UCHIYAMA

  From 01 Apr. 1998, To 31 Mar. 2002, Project Closed

  HIV-1;AIDS;CCR5;CXCR4;SDF-1;CTL;mucosal immunity;dendritic cells;mucosol immunity;HIV;gp120;粘膜免疫;V3ループ;エイズワクチン, HIV-1;AIDS;Pathophysiology;Immune response;AIDS Control;Chemokine;Chemokine Receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10180102/
• Basic Research for AIDS control A01 ; Host factors necessary for HIV-1 replication

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  TOHOKU UNIVERSITY;The University of Tokyo

  Yoshio KOYANAGI

  From 01 Apr. 1998, To 31 Mar. 2002, Project Closed

  HIV;エイズ;CD4陽性T細胞;NF-κB;ケモカインレセプター;レトロウイルス;インテグレーション;核外移行;ゲノム;TAT;インテグレース;REV;核内因子;HIV-1;gp41;Nef;阻害剤;RANTES;サル細胞;SIV;SDFA;CD26;糖鎖;逆転写;アクセサリー蛋白;サブタイプEゲノム, HIV-1;AIDS;CD4(+) T cell;NF-kappaB;Chemokine receptor;Retrovirus;Integration;Nuclear export

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10180101/
• エイズの基礎研究の動向調査と将来展望

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  内山 卓

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  エイズ;HIV;ケモカイン;CTL;抗HIV剤;HIV複製;宿主因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09897017/
• Study of Leukemogenesis in Adult T-Cell Leukemia using SCID mouse model

  Grant-in-Aid for General Scientific Research (B)

  Tokyo Medical and Dental University

  Yoshio KOYANAGI

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  SCIDマウス;ATL;HTLV-I;Tリンパ腫, SCID mouse;ATL;HTLV-I;T cell lymphoma

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454210/
• SCIDマウスによるHIV病原性の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Tokyo Medical and Dental University

  小柳 義夫

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  SCIDマウス;HIV;エイズモデル動物;ヒトリンパ球構築;リンパ節;胸腺

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06255101/
• 神経親和性ヒトレトロウイルスによる神経障害機構の分子遺伝学的及び細胞生物学的解析

  Grant-in-Aid for General Scientific Research (C)

  Kyushu University

  吉良 潤一

  From 01 Apr. 1991, To 31 Mar. 1993, Project Closed

  HTLV-I;HTLV-I-associated myelopathy;multiple sclerosis;polymerase chain reaction;central nervous system;tax protein;rex protein;HTLVーI;HTLVーII;HTLVーIーassociated myelopathy;retrovirus

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670420/

External funds: others

• Host factors and immune responses in HIV infection

  厚生労働省エイズ対策費

  From 2009, To 2011

  横田泰子
• Collaboration research for enterovirus regulation

  厚生労働省新型インフルエンザ等新興・再興感染症研究事業

  From 2010, To 2011

  清水博之
• Development of HIV vaccine and anti-HIV drug evaluation system by humanized mice

  創薬基盤推進研究事業

  From 2008, To 2010

  田中勇悦

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Interdisciplinary Sciences-E2

  Y102, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Ethics and Integrity(Life Science)

  G103, Spring, Institute for Liberal Arts and Sciences, 0.5
• From 01 Apr. 2023, To 31 Mar. 2024

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Ethics and Integrity(Life Science)

  G103, Spring, Institute for Liberal Arts and Sciences, 0.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Ethics and Integrity(Life Science)

  G103, Spring, Institute for Liberal Arts and Sciences, 0.5
• From Apr. 2011, To Mar. 2012

  微生物学

  Year-long, 医学部
• From Apr. 2011, To Mar. 2012

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2011, To Mar. 2012

  The Front Line of Life Science Research II

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Microbiology

  Year-long, 医学部
• From Apr. 2012, To Mar. 2013

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Microbiology

  Year-long, 医学部（人間健康科学科）
• From Apr. 2013, To Mar. 2014

  Microbiology 2 (Virology)

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Microbiology

  Year-long, 医学部（人間健康科学科）
• From Apr. 2014, To Mar. 2015

  Microbiology 2 (Virology)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Microbiology

  Year-long, 医学部（人間健康科学科）
• From Apr. 2015, To Mar. 2016

  Microbiology 2 (Virology)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Basic Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Microbiology

  Year-long, 医学部（人間健康科学科）
• From Apr. 2016, To Mar. 2017

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Microbiology

  Year-long, 医学部（人間健康科学科）
• From Apr. 2017, To Mar. 2018

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）
• From Apr. 2018, To Mar. 2019

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Infectious disease medicine II

  Spring, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense II (Immunology and Virology)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense I (Microbiology and Virology)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Infectious disease medicine II

  Spring, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense II (Immunology and Virology)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense I (Microbiology and Virology)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Infectious disease medicine II

  Spring, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Infectious disease medicine I

  Fall, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense I

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense II

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科