Basic Information

Academic Degree

• 修士（工学）(東京大学)
• 博士（工学）(東京大学)

Academic Resume (Graduate Schools)

• 東京大学, 大学院工学系研究科応用化学専攻修士課程, 修了
• 東京大学, 大学院工学系研究科応用化学専攻博士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 理学部化学科, 卒業

ID,URL

• J-Global ID

  201801019146354379

researchmap URL

• https://researchmap.jp/7000023066

Research

Research Topics, Overview of the research

• Research Topics

  Molecualr Self-assembly

Research Areas

• Nanotechnology/Materials, Nanostructure chemistry

Papers

• High throughput formation of sub-million lipid membrane arrays for measuring membrane protein activities

  R. Watanabe; D. Fujita; K. V. Tabata; L. Yamauchi; N. Soga; S. H. Kim; H. Suga; H. Noji

  17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 2013

  
• Physical Isolation of Single Protein Molecules within Well‐Defined Coordination Cages to Enhance Their Stability

  Risa Ebihara; Takahiro Nakama; Ken Morishima; Maho Yagi‐Utsumi; Masaaki Sugiyama; Daishi Fujita; Sota Sato; Makoto Fujita

  Angewandte Chemie International Edition, 10 Feb. 2025

  
• Physical Isolation of Single Protein Molecules within Well‐Defined Coordination Cages to Enhance Their Stability

  Risa Ebihara; Takahiro Nakama; Ken Morishima; Maho Yagi‐Utsumi; Masaaki Sugiyama; Daishi Fujita; Sota Sato; Makoto Fujita

  Angewandte Chemie, 10 Feb. 2025

  
• Hysteresis behavior in the unfolding/refolding processes of a protein trapped in metallo-cages.

  Takahiro Nakama; Anouk Rossen; Risa Ebihara; Maho Yagi-Utsumi; Daishi Fujita; Koichi Kato; Sota Sato; Makoto Fujita

  Chemical science, Mar. 2023, Peer-reviewed

  
• MEMによるターゲット構造可視化法の開発：蛋白質を封じ込めた人工カプセルの合成と構造決定

  水野伸宏; 藤田大士; 佐藤宗太; 熊坂崇; 藤田誠; 高田昌樹

  日本結晶学会誌, 2013, Peer-reviewed, Invited

  
• Coordination/metal–organic cages inside out

  Tomoki Tateishi; Masahiko Yoshimura; Shun Tokuda; Fuyuki Matsuda; Daishi Fujita; Shuhei Furukawa

  Coordination Chemistry Reviews, Sep. 2022, Peer-reviewed

  
• Protein stabilization and refolding in a gigantic self-assembled cage

  Daishi Fujita; Ryoto Suzuki; Yuya Fujii; Mayu Yamada; Takahiro Nakama; Akimasa Matsugami; Fumiaki Hayashi; Jing-Ke Weng; Maho Yagi-Utsumi; Makoto Fujita

  Chem, Oct. 2021, Peer-reviewed

  
• Crystalline‐Sponge‐Based Structural Analysis of Crude Natural Product Extracts

  Naoki Wada; Roland D. Kersten; Takahiro Iwai; Shoukou Lee; Fumie Sakurai; Takashi Kikuchi; Daishi Fujita; Makoto Fujita; Jing‐Ke Weng

  Angewandte Chemie, 26 Mar. 2018, Peer-reviewed

  
• An Organometallic Strategy for Assembling Atomically Precise Hybrid Nanomaterials

  Julia M. Stauber; Elaine A. Qian; Yanxiao Han; Arnold L. Rheingold; Petr Král; Daishi Fujita; Alexander M. Spokoyny

  Journal of the American Chemical Society, 08 Jan. 2020, Peer-reviewed

  
• Crystalline-Sponge-Based Structural Analysis of Crude Natural Product Extracts

  Naoki Wada; Roland D. Kersten; Takahiro Iwai; Shoukou Lee; Fumie Sakurai; Takashi Kikuchi; Daishi Fujita; Makoto Fujita; Jing-Ke Weng

  Angewandte Chemie - International Edition, 26 Mar. 2018, Peer-reviewed

  
• A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-Scale NMR-Coupled Crystalline Sponge X-ray Diffraction Analysis

  Roland D. Kersten; Shoukou Lee; Daishi Fujita; Tomas Pluskal; Susan Kram; Jennifer E. Smith; Takahiro Iwai; Joseph P. Noel; Makoto Fujita; Jing-Ke Weng

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2017, Peer-reviewed

  
• Permeable Self-Assembled Molecular Containers for Catalyst Isolation Enabling Two-Step Cascade Reactions

  Yoshihiro Ueda; Hiroaki Ito; Daishi Fujita; Makoto Fujita

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2017, Peer-reviewed

  
• Self-assembly of tetravalent Goldberg polyhedra from 144 small components

  Daishi Fujita; Yoshihiro Ueda; Sota Sato; Nobuhiro Mizuno; Takashi Kumasaka; Makoto Fujita

  NATURE, Dec. 2016, Peer-reviewed

  
• Self-Assembly of M30L60 Icosidodecahedron

  Daishi Fujita; Yoshihiro Ueda; Sota Sato; Hiroyuki Yokoyama; Nobuhiro Mizuno; Takashi Kumasaka; Makoto Fujita

  CHEM, Jul. 2016, Peer-reviewed

  
• Finely Resolved Threshold for the Sharp M12L24/M24L48 Structural Switch in Multi-Component MnL2n Polyhedral Assemblies: X-ray, MS, NMR, and Ultracentrifugation Analyses

  Hiroyuki Yokoyama; Yoshihiro Ueda; Daishi Fujita; Sota Sato; Makoto Fujita

  CHEMISTRY-AN ASIAN JOURNAL, Oct. 2015, Peer-reviewed

  
• Fitting Proteins into Metal Organic Frameworks

  Daishi Fujita; Makoto Fujita

  ACS CENTRAL SCIENCE, Oct. 2015, Peer-reviewed

  
• A Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins

  Sota Sato; Yutaka Yoshimasa; Daishi Fujita; Maho Yagi-Utsumi; Takumi Yamaguchi; Koichi Kato; Makoto Fujita

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2015, Peer-reviewed

  
• A Self-Assembled Spherical Complex Displaying a Gangliosidic Glycan Cluster Capable of Interacting with Amyloidogenic Proteins

  Sota Sato; Yutaka Yoshimasa; Daishi Fujita; Maho Yagi-Utsumi; Takumi Yamaguchi; Koichi Kato; Makoto Fujita

  Angewandte Chemie, May 2015, Peer-reviewed

  
• Geometrically Restricted Intermediates in the Self-Assembly of an M12L24 Cuboctahedral Complex

  Daishi Fujita; Hiroyuki Yokoyama; Yoshihiro Ueda; Sota Sato; Makoto Fujita

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jan. 2015, Peer-reviewed

  
• Emergent Ion-Gated Binding of Cationic Host-Guest Complexes within Cationic M12L24 Molecular Flasks

  Carson J. Bruns; Daishi Fujita; Manabu Hoshino; Sota Sato; J. Fraser Stoddart; Makoto Fujita

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014, Peer-reviewed

  
• Emergent ion-gated binding of cationic host-guest complexes within cationic M12L24 molecular flasks

  Carson J. Bruns; Daishi Fujita; Sota Sato; J. Fraser Stoddart; Makoto Fujita

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014, Peer-reviewed

  
• Arrayed lipid bilayer chambers allow single-molecule analysis of membrane transporter activity

  Rikiya Watanabe; Naoki Soga; Daishi Fujita; Kazuhito V. Tabata; Lisa Yamauchi; Soo Hyeon Kim; Daisuke Asanuma; Mako Kamiya; Yasuteru Urano; Hiroaki Suga; Hiroyuki Noji

  NATURE COMMUNICATIONS, Jul. 2014, Peer-reviewed

  
• Challenges to large molecular encapsulation

  Daishi Fujita

  PURE AND APPLIED CHEMISTRY, Jan. 2014, Peer-reviewed

  
• Stepwise DNA condensation by a histone-mimic peptide-coated M12L24 spherical complex

  Takashi Kikuchi; Sota Sato; Daishi Fujita; Makoto Fujita

  CHEMICAL SCIENCE, 2014, Peer-reviewed

  
• Development of a MEM Structure Visualization Method: Synthesis and Structural Analysis of Artificial Capsule Enclosing Protein

  Daishi Fujita

  J. Crystallogr. Soc. Jap, 2013, Peer-reviewed

  
• Giant hollow MnL2n spherical complexes: structure, functionalisation and applications

  Kate Harris; Daishi Fujita; Makoto Fujita

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• Protein encapsulation within synthetic molecular hosts

  Daishi Fujita; Kosuke Suzuki; Sota Sato; Maho Yagi-Utsumi; Yoshiki Yamaguchi; Nobuhiro Mizuno; Takashi Kumasaka; Masaki Takata; Masanori Noda; Susumu Uchiyama; Koichi Kato; Makoto Fujita

  NATURE COMMUNICATIONS, Oct. 2012, Peer-reviewed

  
• Synthesis of a Bridging Ligand with a Non-denatured Protein Pendant: Toward Protein Encapsulation in a Coordination Cage

  Daishi Fujita; Kosuke Suzuki; Sota Sato; Maho Yagi-Utsumi; Eiji Kurimoto; Yoshiki Yamaguchi; Koichi Kato; Makoto Fujita

  CHEMISTRY LETTERS, Mar. 2012, Peer-reviewed

  
• Self-Assembly of Pt(II) Spherical Complexes via Temporary Labilization of the Metal-Ligand Association in 2,2,2-Trifluoroethanol

  Daishi Fujita; Asana Takahashi; Sota Sato; Makoto Fujita

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011, Peer-reviewed

  
• Parallel-Stacked Aromatic Hosts for Orienting Small Molecules in a Magnetic Field: Induced Residual Dipolar Coupling by Encapsulation

  Sota Sato; Osamu Morohara; Daishi Fujita; Yoshiki Yamaguchi; Koichi Kato; Makoto Fujita

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2010, Peer-reviewed

  
• Activation of 1,1-difluoro-1-alkenes with a transition-metal complex: Palladium(II)-catalyzed Friedel-Crafts-type cyclization of 4,4-(difluorohomoallyl)arenes

  Misaki Yokota; Daishi Fujita; Junji Ichikawa

  ORGANIC LETTERS, Oct. 2007, Peer-reviewed

  

Misc.

• NMR analysis of dimerization of amyloid β hydrophobic fragments by encapsulation in a giant spherical metallo-cage

  小野寺悠太; 竹内絵里奈; 中間貴寛; 矢木真穂; 藤田大士; 加藤晃一; 藤田誠; 藤田誠; 藤田誠

  日本化学会春季年会講演予稿集(Web), 2024

  
• Structural Analysis of Amyloid β Fragment Dimer Isolated in a Giant Metal Coordination Cage

  中間貴寛; 小野寺悠太; 竹内絵里奈; 矢木真穂; 矢木真穂; 藤田大士; 加藤晃一; 加藤晃一; 藤田誠; 藤田誠; 藤田誠

  基礎有機化学討論会要旨集, 2023

  
• Hysteretic Unfolding-Refolding of a Protein Confined in M₁₂L₂₄ Spherical Cages

  中間貴寛; ANOUK Rossen; 海老原梨沙; 矢木真穂; 矢木真穂; 藤田大士; 加藤晃一; 加藤晃一; 藤田誠; 藤田誠

  ホスト-ゲスト・超分子化学シンポジウム講演要旨集, 2023

  
• Structure analysis of amyloid-β hydrophobic fragments in the initial aggregation by confinement within a hollow self-assembled cage

  竹内絵里奈; 中間貴寛; 矢木真穂; 藤田大士; 加藤晃一; 藤田誠; 藤田誠

  日本化学会春季年会講演予稿集(Web), 2022

  
• Observation of amyloid-β dimeric structures via the encapsulation in an M₁₂L₂₄ hollow complex

  中間貴寛; 竹内絵里奈; 矢木真穂; 藤田大士; 加藤晃一; 藤田誠; 藤田誠

  ホスト-ゲスト・超分子化学シンポジウム講演要旨集, 2022

  
• Encapsulation of amyloid β C-terminal cohesive fragments into a self-assembled cage complex for structural analysis of the initial oligomeric state

  竹内絵里奈; 鈴木亮人; 中間貴寛; 矢木真穂; 藤田大士; 加藤晃一; 藤田誠; 藤田誠

  日本化学会春季年会講演予稿集(Web), 2021

  
• Encapsulation of amyloid β protein into self-assembled M₁₂L₂₄ spherical complex

  陳村拓也; 鈴木亮人; 藤田大士; 矢木真穂; 加藤晃一; 藤田誠

  日本化学会春季年会講演予稿集(CD-ROM), 2020

  

Awards

• 07 Apr. 2023

  令和５年度 科学技術分野の文部科学大臣表彰 若手科学者賞
• Mar. 2018

  Royal Society of Chemisty / Chemical Society of Japan, 2018 PCCP Prizes for Outstanding Achievement of Young Scientists in Physical Chemistry and Chemical Physics
• Jun. 2013

  Reaxys – Reed Elsevier Properties SA, Reaxys PhD Prize 2013 Finalist
• Jun. 2013

  The International Union of Pure and Applied Chemistry (IUPAC), IUPAC Prizes for Young Chemists 2013

External funds: Kakenhi

• Protein Folding Analysis:Protein Encapsulation within Heavy-Atom Containing Structures

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  DAISHI FUJITA

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  タンパク質;自己集合分子;ホスト-ゲスト化合物;パラジウム;電子顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22252/
• Protein Encapsulation by Synthetic Cages for Functional Control and Structure Determination

  Grant-in-Aid for Specially Promoted Research

  Science and Engineering

  Institute for Molecular Science

  藤田 誠

  From 23 Apr. 2019, To 31 Mar. 2024, Granted

  タンパク質;自己組織化;中空錯体;構造解析;空間捕捉;包接;NMR;X線回折;タンパク包接;NMR構造解析;X線構造解析;タンパク質包接;自己集合;ケージ化合物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H05461/
• Development of three-dimensional protein modification method towards ambient temperature transportation and storage of biologics

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37010:Bio-related chemistry

  Kyoto University

  DAISHI FUJITA

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  自己集合分子;ホスト-ゲスト化合物;タンパク質;パラジウム;自己集合

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H02833/
• Self-assembled porous coordination networks as crystalline molecular flasks

  Grant-in-Aid for Specially Promoted Research

  Science and Engineering

  The University of Tokyo

  Makoto FUJITA

  From 01 Apr. 2012, To 31 Mar. 2018, Project Closed

  自己組織化;分子認識;ナノ空間;X線構造解析;配位結合;単結晶構造解析;ホストーゲスト化学;ホストゲスト化学;ホスト－ゲスト化学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24000009/
• Development of a platform for rapid structural analysis of transient protein complexes.

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (II)

  Kansai Medical University

  Ryoji SUNO

  From 23 Aug. 2021, To 31 Mar. 2024, Project Closed

  GPCR;クライオ電子顕微鏡単粒子解析;シグナル伝達;SBDD;膜タンパク質;鎮痛;創薬;バイアスドリガンド;X線結晶構造解析;自己集合ナノケージ

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21H05112/
• タンパク質分子ケージ化法の膜タンパク質への拡張

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37010:Bio-related chemistry

  Kyoto University

  藤田 大士

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  自己集合;タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02084/
• タンパク質分子ケージ化法の膜タンパク質への拡張

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37010:Bio-related chemistry

  Kyoto University

  藤田 大士

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  自己集合;タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K26777/
• Clarifying Mechanisms Behind Individual Variability and Changes in Metabolism and Thermogenic Function

  Grant-in-Aid for Scientific Research (B)

  Basic Section 59040:Nutrition science and health science-related

  The University of Tokyo

  安部 一太郎

  From 01 Apr. 2025, To 31 Mar. 2029, Granted

  心外膜脂肪;心房細動;前駆脂肪細胞;代謝;熱産生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K03069/

External funds: others

• 自己集合が導き出す新規多面体群：物質合成と数学的考察

  JSTさきがけ

  From 01 Oct. 2015, To 31 Mar. 2019

  代表

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Molecular assembly in chemistry and biology

  N930, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Integrated Liberal Arts and Science with Small Group Seminar s

  Y103, Spring, Institute for Liberal Arts and Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular assembly in chemistry and biology

  N930, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular assembly in chemistry and biology

  N930, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular assembly in chemistry and biology

  N930, Fall, Institute for Liberal Arts and Sciences, 2
• From Apr. 2019, To Mar. 2020

  Molecular assembly in chemistry and biology

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Molecular assembly in chemistry and biology

  Fall, 全学共通科目
• From Apr. 2021, To Mar. 2022

  ILAS Seminar : Research project design using cutting-edge biotechnology

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Molecular assembly in chemistry and biology

  Fall, 全学共通科目

Administration

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2024

  高等研究院物質―細胞統合システム拠点主任研究者会議議長