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Shimobayashi, Shunsuke
Center for iPS Cell Research and Application (CiRA) Associate Professor
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Last Updated :2026/05/21
Basic Information
Concurrent Affiliation
Email Address
Email Address
shimobayashi.shunsuke.3t
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Graduate Schools)
Academic Resume (Undergraduate School/Majors)
Research History
- From Apr. 2025, To PresentJST FOREST researcher
- From Oct. 2024, To PresentKyoto University, Institute for Integrated Cell-Material Sciences (iCeMS), Collabo PI
- From May 2022, To Mar. 2025JST Presto Researcher
- From May 2022, To PresentAssociate Professor (PI), Center for iPS Cell Research and Application (CiRA), Kyoto University
- From Apr. 2020, To Mar. 2022Princeton University, 化学生物工学科, JSPS Postdoctoral Fellow
- From Sep. 2018, To Mar. 2020Princeton Universiy, 化学生物工学科, Visiting Associate Research Scholar
- From Oct. 2016, To Mar. 2020Japan Agency for Marine-Earth Science and Technology, Department of Mathematical Science and Advanced Technology, Scientist
- From Apr. 2016, To Mar. 2017École Normale Supérieure (Paris), Postdoctoral Research fellow
ID,URL
ORCID ID
J-Global ID
Researcher number
50787124
researchmap URL
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Last Updated :2026/05/21
Research
Papers
- Multi-dimensional condensation of intracellular biomoleculesMasataka Yanagawa; Shunsuke F; ShimobayashiThe Journal of Biochemistry (Invited Review), 22 Nov. 2023, Peer-reviewed
- Critical capillary waves of biomolecular condensatesShunsuke F Shimobayashi; Paul J. Ackerman; Tomo Kurimura; Takashi Taniguchi; Clifford P brangwynnebioArxiv, 01 Nov. 2023
- 3C1522 Quantitative evaluation of DNA double-strand breaks by low gamma-ray radiation : Application of single DNA observation(3C Molecular genetics & Gene expression, Development & Differentation, Radiobiology & Active oxygen,The 49th Annual Meeting of the Biophysical Society of Japan)Shimobayashi Shunsuke; Yoshikawa Kenichi; Yoshikawa Yuko; Mori ToshiakiSeibutsu Butsuri, 2011
- Nucleation landscape of biomolecular condensatesShunsuke F. Shimobayashi; Pierre Ronceray; David W. Sanders; Mikko P. Haataja; Clifford P. BrangwynneNature, 18 Nov. 2021
- Properties of repression condensates in living Ciona embryosNicholas Treen; Shunsuke F. Shimobayashi; Jorine Eeftens; Clifford P. Brangwynne; Michael LevineNature Communications, Dec. 2020, Peer-reviewed
- Nucleated transcriptional condensates amplify gene expressionMing-Tzo Wei; Yi-Che Chang; Shunsuke F. Shimobayashi; Yongdae Shin; Amy R. Strom; Clifford P. BrangwynneNature Cell Biology, Oct. 2020, Peer-reviewed
- Intracellular Organelles Driven by Liquid-Liquid Phase SeparationShunsuke F. SHIMOBAYASHI; Yuki OHSAKISeibutsu Butsuri, 2020, Peer-reviewed
- Universal phase behaviors of intracellular lipid dropletsShunsuke F. Shimobayashi; Yuki OhsakiProceedings of the National Academy of Sciences of the United States of America, 17 Dec. 2019, Peer-reviewed
- Suppression of the coffee-ring effect by sugar-assisted depinning of contact lineShunsuke F. Shimobayashi; Mikiko Tsudome; Tomo KurimuraScientific Reports, 01 Dec. 2018, Peer-reviewed
- Direct observations of transition dynamics from macro- to micro-phase separation in asymmetric lipid bilayers induced by externally added glycolipidsShunsuke F. Shimobayashi; Masatoshi Ichikawa; Takashi TaniguchiEPL, Mar. 2016, Peer-reviewed
- Nanoscale hydration dynamics of DNA-lipid blend dry films: DNA-size dependencyS. F. Shimobayashi; M. Hishida; T. Kurimura; M. IchikawaPhysical Chemistry Chemical Physics, 2016, Peer-reviewed
- Molecular behavior of DNA in a cell-sized compartment coated by lipidsTsutomu Hamada; Rie Fujimoto; Shunsuke F. Shimobayashi; Masatoshi Ichikawa; Masahiro TakagiPhysical Review E, 29 Jun. 2015, Peer-reviewed
- Direct measurement of DNA-mediated adhesion between lipid bilayersS. F. Shimobayashi; B. M. Mognetti; L. Parolini; D. Orsi; P. Cicuta; L. Di MichelePhysical Chemistry Chemical Physics, 28 Jun. 2015, Peer-reviewed
- 18pCT-5 Transition dynamics of macro- to micro-phase separation in asymmetric lipid bilayersShimobayashi S. F.; Ichikawa M.; Taniguchi T.Meeting Abstracts of the Physical Society of Japan, 2015
- Emergence of DNA-encapsulating liposomes from a DNA-lipid blend filmShunsuke F. Shimobayashi; Masatoshi IchikawaJournal of Physical Chemistry B, 11 Sep. 2014, Peer-reviewed
- Probability of double-strand breaks in genome-sized DNA by γ-ray decreases markedly as the DNA concentration increasesShunsuke F. Shimobayashi; Takafumi Iwaki; Toshiaki Mori; Kenichi YoshikawaJournal of Chemical Physics, 07 May 2013, Peer-reviewed
Misc.
- 24aPS-34 Linear dependence of probability of DNA double-strand break vs. gamma-ray irradiation as evidenced by direct DNA observationShimobayashi S.; Yoshikawa K.; Mori T.; Yoshikawa Y.Meeting abstracts of the Physical Society of Japan, 24 Aug. 2011
- 26pPSB-48 Attempt to evaluate the reactions of DNA double-strand breaks by radiation quantitativelyShimobayashi S.; Suzuki M.; Yoshikawa Y.; Mori T.; Yoshikawa K.Meeting abstracts of the Physical Society of Japan, 03 Mar. 2011
- Phase-separation transitions in asymmetric lipid bilayersShunsuke F. Shimobayashi; Masatoshi Ichikawa; Takashi Taniguchi13 Apr. 2015
Presentations
- ナノスケール相分離生物学の創成下林 俊典2024年度第2回バイオ単分子研究会, 17 Mar. 2025
- 物理・工学・医学の融合から拡張するナノスケール相分離生物学下林 俊典ニコン相分離シーズウェビナー, 23 Jan. 2025
- Decoding the inside of neuronal condensates through super-resolution microscopy and soft matter theories下林 俊典定量生物学の会 九州キャラバン2025, 11 Jan. 2025
- ナノスケール相分離⽣物学の創成: 物理・工学・医学の融合から下林 俊典JSTさきがけ（動的高次構造体）に関連する相分離workshop, 12 Dec. 2024
- Aggregation Process of Neurodegenerative Disease-Related Proteins Through Physics下林 俊典第47回日本分子生物学会年会, 29 Nov. 2024
- Controlling reprogramming at single cell resolution下林 俊典CRM-CiRA workshop, 12 Nov. 2024
- 光操作と超解像イメージングで探る膜界面相分離のメカニズム下林 俊典第97回日本生化学会大会, 07 Nov. 2024
- 4D reprogramming: direct super-resolution imaging of nanoscale reprogramming condensates工藤 和哉第4回研究交流サロン, 26 Sep. 2024
- Structure and dynamics of biomolecuar condensates to control intracellular information processing下林 俊典第76回日本細胞生物学会大会, 19 Jul. 2024, Invited
- "Manipulating and elucidating the nucleation process of biomolecular condensates in living cells"下林 俊典IUPAB2024シンポジウム, 27 Jun. 2024
- Probing and manipulating biomolecular condensates下林 俊典第24回日本蛋白質科学会年会, 13 Jun. 2024, Invited
- Structure and dynamics of biomolecuar condensates to control intracellular information processing下林 俊典NYU Abu Dhabi Physics Seminar, 29 Apr. 2024, Invited
- Intracellulr molecular assemblies driven by liquid-liquid phase separationThe 101st CSJ Annual Meeting, 19 Mar. 2021, Invited
- Spatial organization of biomolecular liquid condensates by IDRThe 43rd Annual Meeting of the Molecular Biology Society of Japan, 2020, Invited
- Liquid-liquid crystal phase transitions in intracellular lipid dropletsThe 58th Annual Meeting of the Biophysical Society of Japan, 2020, Invited
- Emergence of DNA-encapsulating liposomes from a DNA− Lipid blend filmThe 55th Annual Meeting of the Biophysical Society of Japan, 2017, Invited
Books and Other Publications
- THE CELL下林俊典, Joint work（株）ニューサイエンス社, 20 Feb. 2024
- Promising Construction and Applications of Artificial Smart-CellsShunsuke F. Shimobayashi and Tsutomu Hamada, Joint work, Section 4 of Chapter 2, pp.67-74CMC Publishing Co.,Ltd, Jan. 2017
Awards
External funds: Kakenhi
- Biophysical principles of liquid-liquid crystal phase transition in macrophage lipid dropletsGrant-in-Aid for Early-Career ScientistsBasic Section 13040:Biophysics, chemical physics and soft matter physics-relatedKyoto University;Japan Agency for Marine-Earth Science and TechnologyShunsuke ShimobayashiFrom 01 Nov. 2021, To 31 Mar. 2023, Project Closed相転移;液晶;脂肪滴;オルガネラ;ソフトマター;相分離
- Physical Properties and Functions of Membraneless Organelles Revealed Through Interfacial FluctuationsGrant-in-Aid for Early-Career ScientistsBasic Section 13040:Biophysics, chemical physics and soft matter physics-relatedKyoto UniversityShunsuke ShimobayashiFrom 01 Apr. 2023, To 31 Mar. 2025, Project Closed液液相分離;非膜型オルガネラ;細胞内相分離;界面;揺らぎ
- 膜界面における分子光操作と数理的ダイナミクス解析Grant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)Kyoto University下林 俊典From 01 Apr. 2025, To 31 Mar. 2030, Granted液液相分離
- Autophagy expanded: decoding membrane interface biologyGrant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)Hokkaido University野田 展生From 01 Apr. 2025, To 31 Mar. 2030, Granted膜界面;相分離;オートファジー;分子協奏
