Basic Information

Faculty

• 薬学部

Professional Memberships

• 日本時間生物学会
• THE JAPAN NEUROSCIENCE SOCIETY
• THE PHARMACEUTICAL SOCIETY OF JAPAN
• 日本分子生物学会
• 日本内分泌学会

Academic Degree

• 修士（薬科学）(京都大学)
• 博士（薬科学）(京都大学)

Research History

• From Apr. 2025, To Present

  Kwansei Gakuin University, School of Biological and Environmental Sciences Department of Biomedical Sciences, Associate Professor
• From Oct. 2018, To Mar. 2025

  Graduate School of Pharmaceutical Sciences, Kyoto University, Department of Systems Biology, Assistant Professor
• From May 2018, To Nov. 2018

  JSPS Overseas Research Fellowships
• From May 2017, To Nov. 2018

  University of California, San Francisco, Department of Physiology, Postdoctoral scholar
• From Apr. 2017, To Apr. 2017

  Graduate School of Pharmaceutical Sciences, Kyoto University, Department of Molecular Pharmacology, Researcher
• From Apr. 2016, To Apr. 2017

  JSPS Research Fellowships for Young Scientists (DC2 --> PD)
• Kyoto University, 助教

Profile

• Profile

  I have a broad interest in how ion channels are regulated and why they are crucial in our body. When I was a graduate school student, I have focused on the molecular macinery of Transient Receptor Poteintial (TRP) channels and their role in the field of immunology, cell biology and neuroscience. As a postdoc in UCSF, I was trying to figure out the molecular property of ion channels in mitochondrial inner membrane using direct patch-clamp technique.

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201801005635411244

• Researcher number

  70836866

• External link

  https://sci-tech.ksc.kwansei.ac.jp/~miyake/

researchmap URL

• https://researchmap.jp/miyaketakahito

Research

Research Topics, Overview of the research

• Overview of the research

  One of the goals of my study is to reveal the molecular mechanisms by which the rhythms of biological clocks in most tissues other than that in the suprachiasmatic nucleus (SCN, which composes the master clock) are orchestrated, harmoniously, by an array of direct or indirect signals from the SCN.

Research Interests

• 温度生物学
• Molecular Biology
• Biochemistry
• Neuroscience
• Circadian clock

Research Areas

• Life sciences, Metabolism and endocrinology
• Life sciences, Neuroscience - general
• Life sciences, Cell biology
• Life sciences, Molecular biology

Papers

• Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cells

  Tomohiro Otani; Takahito Miyake; Takumi Ota; Daisuke Yarimizu; Yuuki Nakagawa; Iori Murai; Hitoshi Okamura; Emi Hasegawa; Masao Doi

  Frontiers in Endocrinology, 26 Mar. 2025, Peer-reviewed, Lead author

  
• Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity

  Khanh Tien Nguyen Pham; Takahito Miyake; Tomo Suzuki; Shigeru Kinoshita; Yuki Hamada; Hikari Uehara; Mamiko Machida; Takeshi Nakajima; Emi Hasegawa; Masao Doi

  iScience, Feb. 2025, Peer-reviewed

  
• Circadian Clock and Body Temperature

  Takahito Miyake; Yuichi Inoue; Yota Maekawa; Masao Doi

  Advances in Experimental Medicine and Biology, 18 Sep. 2024

  
• Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.

  Takahito Miyake; Kaho Tanaka; Yutsuki Inoue; Yuji Nagai; Reo Nishimura; Takehito Seta; Shumpei Nakagawa; Ken-Ichi Inoue; Emi Hasegawa; Takafumi Minamimoto; Masao Doi

  Cell reports methods, 21 Oct. 2024, Peer-reviewed, Lead author, Corresponding author

  Access this paper :

  
• Omeprazole Induces CYP3A4 mRNA Expression but Not CYP3A4 Protein Expression in HepaRG Cells

  Yuto Fujita; Takahito Miyake; Xinyan Shao; Yuto Aoki; Emi Hasegawa; Masao Doi

  Biological and Pharmaceutical Bulletin, 27 Jun. 2024, Peer-reviewed, Lead author, Corresponding author

  
• Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K Activation

  Xinyan Shao; Takahito Miyake; Yuichi Inoue; Emi Hasegawa; Masao Doi

  Biological and Pharmaceutical Bulletin, 05 Mar. 2024, Peer-reviewed, Lead author, Corresponding author

  
• The regulatory effect of oxaliplatin on human TRPA1 cold sensitivity

  Miyake Takahito; Nakamura Saki; Zhao Meng; So Kanako; Inoue Keisuke; Numata Tomohiro; Takahashi Nobuaki; Shirakawa Hisashi; Mori Yasuo; Nakagawa Takayuki; Kaneko Shuji

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017, Peer-reviewed

  
• Involvement of TRPA1 activation through distinct modifications in oxaliplatin-induced acute peripheral neuropathy

  Nakamura Saki; Miyake Takahito; Zhao Meng; Hamano Satoshi; Inoue Keisuke; Takahashi Nobuaki; Numata Tomohiro; Shirakawa Hisashi; Mori Yasuo; Nakagawa Takayuki; Kaneko Shuji

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, Peer-reviewed

  
• Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts

  Kotaro Tomuro; Mari Mito; Hirotaka Toh; Naohiro Kawamoto; Takahito Miyake; Siu Yu A. Chow; Masao Doi; Yoshiho Ikeuchi; Yuichi Shichino; Shintaro Iwasaki

  Nature Communications, 26 Aug. 2024, Peer-reviewed

  
• Hypoxia-induced sensitization of TRPA1 to ROS underlies painful dysesthesia evoked by transient hindlimb ischemia/reperfusion

  So Kanako; Tei Yuna; Zhao Meng; Miyake Takahito; Shirakawa Hisashi; Nakagawa Takayuki; Matsubara Kazuo; Kaneko Shuji

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016, Peer-reviewed

  
• Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.

  Takahito Miyake; Yuichi Inoue; Xinyan Shao; Takehito Seta; Yuto Aoki; Khanh Tien Nguyen Pham; Yuichi Shichino; Junko Sasaki; Takehiko Sasaki; Masahito Ikawa; Yoshiaki Yamaguchi; Hitoshi Okamura; Shintaro Iwasaki; Masao Doi

  Cell reports, 28 Feb. 2023, Peer-reviewed, Lead author

  Access this paper :

  
• Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining.

  Yuki Hamada; Lena Sasaki; Hikari Uehara; Tomo Suzuki; Shigeru Kinoshita; Kento Otsuka; Akio Kihara; Yoshiaki Yamaguchi; Takahito Miyake; Masao Doi

  The ocular surface, 06 Oct. 2022, Peer-reviewed

  Access this paper :

  
• Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.

  Yoshiaki Yamaguchi; Iori Murai; Momoko Takeda; Shotaro Doi; Takehito Seta; Reiko Hanada; Kenji Kangawa; Hitoshi Okamura; Takahito Miyake; Masao Doi

  Biological & pharmaceutical bulletin, 2022, Peer-reviewed

  
• MrgprB4 in trigeminal neurons expressing TRPA1 modulates unpleasant sensations

  Shota Tobori; Haruka Hiyama; Takahito Miyake; Yuichi Yano; Kazuki Nagayasu; Hisashi Shirakawa; Takayuki Nakagawa; Yasuo Mori; Shuji Kaneko

  Journal of Pharmacological Sciences, Aug. 2021, Peer-reviewed

  Access this paper :

  
• Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements

  Hiroyuki Shimatani; Yuichi Inoue; Yota Maekawa; Takahito Miyake; Yoshiaki Yamaguchi; Masao Doi

  PLOS ONE, 28 May 2021, Peer-reviewed

  
• Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176

  Tianyu Wang; Shumpei Nakagawa; Takahito Miyake; Genzui Setsu; Sumihiro Kunisue; Kaoru Goto; Akira Hirasawa; Hitoshi Okamura; Yoshiaki Yamaguchi; Masao Doi

  Scientific Reports, Mar. 2020, Peer-reviewed

  Access this paper :

  
• Reconstitution of Organismal Liver Clock Function Requires Light

  Takahito Miyake; Masao Doi

  Trends in endocrinology and metabolism, Sep. 2019, Peer-reviewed, Lead author

  
• Neurotropin inhibits neuronal activity through potentiation of sustained Kv currents in primary cultured DRG neurons.

  Hiroyuki Kawai; Nozomi Asaoka; Takahito Miyake; Kazuki Nagayasu; Takayuki Nakagawa; Hisashi Shirakawa; Shuji Kaneko

  Journal of pharmacological sciences, Jul. 2018, Peer-reviewed

  Access this paper :

  
• TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation.

  Kana Ohashi; Ayane Deyashiki; Takahito Miyake; Kazuki Nagayasu; Koji Shibasaki; Hisashi Shirakawa; Shuji Kaneko

  Pflugers Archiv : European journal of physiology, May 2018, Peer-reviewed

  Access this paper :

  
• Tremor dominant Kyoto (Trdk) rats carry a missense mutation in the gene encoding the SK2 subunit of small-conductance Ca2+-activated K+ channel

  Takashi Kuramoto; Mayuko Yokoe; Naofumi Kunisawa; Kana Ohashi; Takahito Miyake; Yuki Higuchi; Kazuto Yoshimi; Tomoji Mashimo; Miyuu Tanaka; Mitusru Kuwamura; Shuji Kaneko; Saki Shimizu; Tadao Serikawa; Yukihiro Ohno

  BRAIN RESEARCH, Dec. 2017, Peer-reviewed

  
• Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin

  Takahito Miyake; Saki Nakamura; Zhao Meng; Satoshi Hamano; Keisuke Inoue; Tomohiro Numata; Nobuaki Takahashi; Kazuki Nagayasu; Hisashi Shirakawa; Yasuo Mori; Takayuki Nakagawa; Shuji Kaneko

  FRONTIERS IN PHYSIOLOGY, Nov. 2017, Peer-reviewed, Lead author

  
• Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes

  Hisashi Shirakawa; Rumi Katsumoto; Shota Iida; Takahito Miyake; Takuya Higuchi; Takuya Nagashima; Kazuki Nagayasu; Takayuki Nakagawa; Shuji Kaneko

  GLIA, Jun. 2017, Peer-reviewed

  Access this paper :

  
• 

  A study of the mechanisms of ROS-mediated TRP channel control

  Takahito Miyake

  Mar. 2017, Peer-reviewed, Lead author, Last author, Corresponding author

  
• Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

  Takahito Miyake; Saki Nakamura; Meng Zhao; Kanako So; Keisuke Inoue; Tomohiro Numata; Nobuaki Takahashi; Hisashi Shirakawa; Yasuo Mori; Takayuki Nakagawa; Shuji Kaneko

  NATURE COMMUNICATIONS, Sep. 2016, Peer-reviewed, Lead author

  Access this paper :

  
• Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice

  Kanako So; Yuna Tei; Meng Zhao; Takahito Miyake; Haruka Hiyama; Hisashi Shirakawa; Satoshi Imai; Yasuo Mori; Takayuki Nakagawa; Kazuo Matsubara; Shuji Kaneko

  SCIENTIFIC REPORTS, Mar. 2016, Peer-reviewed

  Access this paper :

  
• Reactive oxygen species signaling in the regulation of microglial functions ̶ TRP channel-mediated novel mechanisms of microglial activation

  Miyake T; Shirakawa H; Nakagawa T; Kaneko S

  Folia Pharmacologica Japonica, Jan. 2016, Peer-reviewed, Lead author

  
• Activation of Mitochondrial Transient Receptor Potential Vanilloid 1 Channel Contributes to Microglial Migration

  Takahito Miyake; Hisashi Shirakawa; Takayuki Nakagawa; Shuji Kaneko

  GLIA, Oct. 2015, Peer-reviewed, Lead author

  Access this paper :

  
• Pharmacological Characterization of Standard Analgesics on Oxaliplatin-Induced Acute Cold Hypersensitivity in Mice

  Meng Zhao; Saki Nakamura; Takahito Miyake; Kanako So; Hisashi Shirakawa; Shogo Tokuyama; Minoru Narita; Takayuki Nakagawa; Shuji Kaneko

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Apr. 2014, Peer-reviewed

  
• TRPM2 contributes to LPS/IFN gamma-induced production of nitric oxide via the p38/JNK pathway in microglia

  Takahito Miyake; Hisashi Shirakawa; Ayaka Kusano; Shinya Sakimoto; Masakazu Konno; Takayuki Nakagawa; Yasuo Mori; Shuji Kaneko

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2014, Peer-reviewed, Lead author

  
• Transient Receptor Potential Canonical 3 Inhibitor Pyr3 Improves Outcomes and Attenuates Astrogliosis After Intracerebral Hemorrhage in Mice

  Masaya Munakata; Hisashi Shirakawa; Kazuki Nagayasu; Jun Miyanohara; Takahito Miyake; Takayuki Nakagawa; Hiroshi Katsuki; Shuji Kaneko

  STROKE, Jul. 2013, Peer-reviewed

  
• Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide

  Masakazu Konno; Hisashi Shirakawa; Shota Iida; Shinya Sakimoto; Ikkei Matsutani; Takahito Miyake; Keiko Kageyama; Takayuki Nakagawa; Koji Shibasaki; Shuji Kaneko

  GLIA, May 2012, Peer-reviewed

  
• Calumin, a Ca2+-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca2+ release-activated Ca2+ (CRAC) channels

  Masakazu Konno; Hisashi Shirakawa; Takahito Miyake; Shinya Sakimoto; Takayuki Nakagawa; Shuji Kaneko

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2012, Peer-reviewed

  
• Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction

  Lena Sasaki; Yuki Hamada; Daisuke Yarimizu; Tomo Suzuki; Hiroki Nakamura; Aya Shimada; Khanh Tien Nguyen Pham; Xinyan Shao; Koki Yamamura; Tsutomu Inatomi; Hironobu Morinaga; Emi K. Nishimura; Fujimi Kudo; Ichiro Manabe; Shogo Haraguchi; Yuki Sugiura; Makoto Suematsu; Shigeru Kinoshita; Mamiko Machida; Takeshi Nakajima; Hiroshi Kiyonari; Hitoshi Okamura; Yoshiaki Yamaguchi; Takahito Miyake; Masao Doi

  Nature Aging, Feb. 2022, Peer-reviewed

  Access this paper :

  
• Roles of the Circadian Clock Mechanism in the Regulation of Daily Rhythms of Body Temperature

  Takahito Miyake; Masao Doi

  Brain and nerve, Feb. 2022, Invited, Lead author

  
• Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.

  Yoshiaki Yamaguchi; Iori Murai; Kaoru Goto; Shotaro Doi; Huihua Zhou; Genzui Setsu; Hiroyuki Shimatani; Hitoshi Okamura; Takahito Miyake; Masao Doi

  Scientific reports, 17 Nov. 2021, Peer-reviewed

  Access this paper :

  

Misc.

• TRPV4開口はミクログリアの活性化状態を抗炎症型へ分極させる

  桑田沙織; 富澤恵里; 三宅崇仁; 永安一樹; 白川久志; 金子周司

  日本薬理学雑誌, 2020

  
• ノイロトロピンは持続性K_v電流増加を介してDRGニューロンの活動を抑制する

  河合洋幸; 浅岡希美; 三宅崇仁; 永安一樹; 中川貴之; 白川久志; 金子周司

  Pain Research, 2018

  
• オリゴデンドロサイト前駆細胞におけるTRPV4開口は増殖を促進する

  大橋佳奈; 出屋敷綾音; 三宅崇仁; 永安一樹; 柴崎貢志; 白川久志; 金子周司

  日本薬理学会近畿部会プログラム・要旨集, 2018

  
• ミクログリアにおいてTRPV4の開口はLPS誘発IL10産生を促進する

  富澤恵里; 三宅崇仁; 永安一樹; 白川久志; 金子周司

  日本薬理学会近畿部会プログラム・要旨集, 2017

  
• オリゴデンドロサイト前駆細胞の増殖および分化におけるTRPV4の生理的役割

  出屋敷綾音; 三宅崇仁; 永安一樹; 白川久志; 中川貴之; 金子周司

  日本薬理学会近畿部会プログラム・要旨集, 2016

  
• オキサリプラチン誘発急性末梢神経におけるTRPA1の関与

  三宅崇仁; 中村彩希; 趙萌; 浜野智; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 中川貴之; 金子周司

  日本薬学会年会要旨集(CD-ROM), 2015

  
• ミクログリア/マクロファージにおけるTRPM2を介したNO産生が脳虚血傷害の増悪に寄与する

  白川久志; 崎元伸哉; 三宅崇仁; 宮之原遵; 筒井真人; 中川貴之; 金子周司

  日本薬学会年会要旨集(CD-ROM), 2014

  
• TRPV1刺激によるミトコンドリア脱分極を介したミクログリアの遊走

  三宅崇仁; 白川久志; 西谷直也; 中川貴之; 中川貴之; 金子周司

  生体機能と創薬シンポジウム要旨集, 2014

  
• オキサリプラチン誘発急性末梢神経障害の発症機構の解析:レドックス感受性TRPA1の関与

  中川貴之; 中川貴之; 趙萌; 中村彩希; 三宅崇仁; 宗可奈子; 白川久志; 金子周司; 松原和夫

  日本医療薬学会年会講演要旨集, 2014

  
• オキサリプラチンによるTRPA1活性化機構における活性酸素種の関与

  三宅崇仁; 趙萌; 中村彩希; 白川久志; 中川貴之; 金子周司

  日本薬理学会近畿部会プログラム・要旨集, 2013

  
• TRPC3阻害薬はマウス脳内出血モデルにおける神経機能障害を改善する

  白川久志; 宗像将也; 宮之原遵; 三宅崇仁; 中川貴之; 金子周司

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 抗がん剤オキサリプラチンによるROSを介したTRPA1活性化

  ZHAO Meng; 三宅崇仁; 中村彩希; 白川久志; 中川貴之; 金子周司

  Pain Research, 2013

  
• Physiological implications of TRPV1 in microglial migration and phagocytosis

  Takahito Miyake; Hisashi Shirakawa; Jun Miyanohara; Takayuki Nakagawa; Shuji Kaneko

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013

  
• TRPV4開口刺激は細胞膜の脱分極を介してミクログリア活性化を抑制する

  白川久志; 金野真和; 三宅崇仁; 飯田将太; 中川貴之; 柴崎貢志; 金子周司

  日本薬学会年会要旨集, 2012

  
• Stimulation of TRPV4 channel suppresses abnormal activation of microglia induced by lipopolisaccharide

  Masakazu Konno; Hisashi Shirakawa; Takahito Miyake; Shota Iida; Takayuki Nakagawa; Koji Shibasaki; Shuji Kaneko

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• Pathophysiological role of TRPM2 channel in microglial activation

  Takahito Miyake; Hisashi Shirakawa; Ayaka Kusano; Shinya Sakimoto; Masakazu Konno; Takayuki Nakagawa; Shuji Kaneko

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012

  
• Involvement of TRPM2 channel in mechanisms underlying microglial activation

  Hisashi Shirakawa; Ayaka Kusano; Takahito Miyake; Masakazu Konno; Takayuki Nakagawa; Shuji Kaneko

  NEUROSCIENCE RESEARCH, 2011

  

Presentations

• 温度と活性酸素種を介した生命の環境適応機構の解明

  三宅崇仁

  日本薬学会第145年会, 28 Mar. 2025, Invited

  
• ポスト転写制御がもたらす生命機能の解明に向けて

  三宅崇仁

  第4回日本神経化学会 若手KYOUEN, 15 Feb. 2025, Invited

  
• 概日体温リズムによる転写によらない生物時計調律機構の解明

  三宅崇仁

  第31回 日本時間生物学会学術大会, 18 Nov. 2024, Invited

  
• Post-transcriptional制御による体内時計時刻調律機構

  三宅崇仁; 藤田悠人; 土居雅夫

  第97回日本生化学会大会, 07 Nov. 2024, Invited

  
• The minimal upstream open reading frame of Per2 has a role in enhancing the integrity of the physiological circadian response

  三宅崇仁; 井ノ上雄一; 土居雅夫

  日本薬学会第144年会, 29 Mar. 2024

  
• Temperature entrainment mechanism of peripheral clocks via circadian body temperature and its role in physiology

  三宅崇仁; 土居雅夫

  第101回日本生理学会大会, 28 Mar. 2024, Invited

  
• 生理的微小温度変化を感知するmRNA翻訳制御エレメントの発見とその生理的意義

  三宅崇仁; 土居雅夫

  第3回 関西RNAクラブ, 25 Mar. 2024, Invited

  
• コア時計遺伝子Per2 の最小単位上流翻訳領域は生物時計の概日体温リズムへの同調に重要である

  三宅 崇仁; 井ノ上 雄一; 土居 雅夫

  2023年度 先端モデル動物プラットフォーム成果発表会, 09 Feb. 2024

  
• 体内時計を介した 概日体温リズムによる 生体恒常性維持機構

  三宅 崇仁; 土居 雅夫

  2023年度 生理学研究所 研究会 「臓器連関による生体恒常性維持機構と生体活動の統合的理解」, 28 Jan. 2024

  
• 非翻訳領域に位置する最小翻訳フレームを介した概日時計温度制御機構

  三宅 崇仁; 井ノ上 雄一; 土居 雅夫

  日本睡眠学会第45回定期学術集会・第30回日本時間生物学会学術大会 合同大会, 17 Sep. 2023, Invited

  
• 体温と翻訳を介した 生物時計の しなやかな調律メカニズム

  三宅崇仁

  大阪大学蛋白質研究所セミナー 「生命のしなやかさに着目したタンパク質研究の現状と展望」, 18 Aug. 2023, Invited

  
• パラメトリックmRNA翻訳速度調節を介した体温による概日時計調律機構

  三宅崇仁; 井ノ上雄一; 土居雅夫

  日本内分泌学会内分泌代謝学サマーセミナー YECシンポジウム, 06 Jul. 2023, Invited

  
• 非翻訳領域の翻訳を介した生理的微小温度変化による生物時計調律

  三宅崇仁; 井ノ上雄一; 土居雅夫

  第5回 量子生命科学会, 19 May 2023, Invited

  
• 生理的な微小温度変化がもたらすmRNA翻訳速度調節を介した概日時計制御機構

  三宅崇仁; 井ノ上雄一; 土居雅夫

  第12回 都医学研シンポジウム, 08 Mar. 2023, Invited

  
• 微小な温度変化がもたらすmRNA翻訳速度調節と概日時計制御

  三宅崇仁; 井ノ上雄一; 土居雅夫

  温熱生理学研究会2022, Sep. 2022, Invited

  
• ミトコンドリアパッチクランプでしか⾒えない世界

  三宅 崇仁

  第4回イオンチャネル研究会, 22 Aug. 2019

  
• The regulatory effect of oxaliplatin on human TRPA1 cold sensitivity

  三宅崇仁; 中村彩希; 趙萌; 宗可奈子; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 金子周司

  第90 回日本薬理学会年, Mar. 2017

  
• 「しびれ」と抗がん剤副作用における一次感覚神経TRPA1 の役割

  三宅崇仁; 金子周司

  第4 回新学術 領域研究「酸素生物学」全体班会議・公開シンポジウム, Feb. 2017, Invited

  
• オキサリプラチン誘発性冷刺激過敏応答におけるTRPA1 の関与

  三宅崇仁; 中村彩希; 趙萌; 宗可奈子; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 金子周司

  平成28 年度岡崎生理研研究会 「痛みの理解を目指した先端的アプローチ」, Jan. 2017

  
• Relief from Prolyl Hydroxylation by Oxaliplatin Allows TRPA1 to Sense Noxious Cold via Transduction of Reactive Oxygen Species Signaling

  Takahito Miyake; Saki Nakamura; Meng Zhao; Kanako So; Hisashi Shirakawa; YasuoMori; Takayuki Nakagawa; Shuji Kaneko

  IASP 16thWorld Congress on Pain, Sep. 2016

  
• TRPA1 チャネルの温度感受性

  三宅崇仁

  第1回イオンチャネル研究, Jul. 2016

  
• Reactive oxygen species-dependent mechanism of cold nociception via TRPA1 channel

  三宅崇仁; 中村彩希; 趙萌; 宗可奈子; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 金子周司

  Neuro2016, Jul. 2016

  
• プロリン水酸化によるTRPA1 チャネルの冷感受性制御機構

  三宅崇仁; 中村彩希; 趙萌; 浜野智; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 金子周司

  TRP チャネル研究会2016, Jun. 2016

  
• オキサリプラチン誘発急性末梢神経障害におけるTRPA1 チャネルの関与

  三宅崇仁; 中村彩希; 趙萌; 浜野智; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 金子周司

  日本臨床腫瘍薬学会 学術大会2015, Mar. 2015

  
• TRPA1 チャネルのオキサリプラチン誘発急性末梢神経障害における役割

  三宅崇仁; 中村彩希; 趙萌; 宗可奈子; 浜野智; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 金子周司

  第24 回神 経行動薬理若手研究者の集い, Mar. 2015

  
• ミクログリア遊走制御に対するミトコンドリアTRPV1 の機 能的関与

  三宅崇仁; 白川久志; 中川貴之; 金子周司

  第88 回日本薬理学会年会, Mar. 2015

  
• オキサリプラチン誘発急性末梢神経におけるTRPA1 の関与

  三宅崇仁; 中村彩希; 趙萌; 浜野智; 井上圭亮; 沼田朋大; 高橋重成; 白川久志; 森泰生; 中川貴之; 金子周司

  日本薬学会第135 年会, Mar. 2015

  
• TRPV1 刺激によるミトコンドリア脱分極を介した ミクログリアの遊走

  三宅崇仁; 白川久志; 西谷直也; 中川貴之; 金子周司

  生体機能と創薬シンポジウム2014, Aug. 2014

  
• ミクログリアにおけるTRPV1 を介した走化性制御

  三宅崇仁; 白川久志; 中川貴之; 金子周司

  TRP チ ャネル研究会2014, Jun. 2014

  
• オキサリプラチンによるTRPA1 の活性化 機構における活性酸素種の関与

  三宅崇仁; 趙萌; 中村彩希; 白川久志; 中川貴之; 金子周司

  第123 回日本薬理学会近畿部会, Jul. 2013

  
• Physiolocical implications of TRPV1 in microglia

  三宅崇仁; 白川久志; 宮之原遵; 中川貴之; 金子周司

  Neuro2013, Jun. 2013

  
• Physiolocical implications of TRPV1 in microglial migration and phagocytosis

  三宅崇仁; 白川久志; 宮之原遵; 中川貴之; 金子周司

  第86 回日本薬理学会年会, Mar. 2013

  
• Pathophysiological role of TRPM2 channel in microglial activation

  三宅崇仁; 白川久志; 草野綾香; 崎元伸哉; 金野真和; 中川貴之; 金子周司

  第85 回日本薬理学会年会, Mar. 2012

  
• 長井記念薬学研究奨励支援事業に支えられた私のキャリアパス

  三宅崇仁

  日本薬学会第142年会, 2022

  
• 微小な温度変化がもたらすmRNA翻訳速度調節と概日時計制御

  三宅崇仁; 井ノ上雄一; 土居雅夫

  Biothermology Workshop - 2021's Annual Workshop, 27 Dec. 2021

  
• 翻訳速度制御を介した体内時計のパラメトリック制御

  三宅崇仁、井ノ上雄一、土居雅夫

  第44回日本分子生物学会年会, 02 Dec. 2021

  
• Parametric entrainment of the circadian clock by body temperature change

  三宅崇仁; 井ノ上雄一; 土居雅夫

  第59回日本生物物理学会年会, 27 Nov. 2021

  

Awards

• 25 Mar. 2022

  公益社団法人日本薬学会, 長井記念若手薬学研究者賞

  Japan, Japan society

  Takahito Miyake

External funds: Kakenhi

• Molecular mechanisms underlying circadian pruritic behavior for chronopharmacology

  Grant-in-Aid for Early-Career Scientists

  Basic Section 47040:Pharmacology-related

  Kyoto University

  Takahito Miyake

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  体内時計;発現制御機構;翻訳;かゆみ;膜タンパク質;炎症応答

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16371/
• 生理的微小温度変化によるuORFを介した生物時計位相制御メカニズムの解明

  Grant-in-Aid for Early-Career Scientists

  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related

  Kyoto University

  三宅 崇仁

  From 01 Apr. 2022, To 31 Mar. 2024, Granted

  体内時計;発現制御機構;翻訳;体温;uORF

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K15274/
• uORFー非翻訳領域の翻訳ーが支配する生命機能の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related

  Kyoto University

  三宅 崇仁

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  体内時計;発現制御機構;翻訳;体温;uORF

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02178/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology III (Clinical Physiology)

  C304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology 4 (Genomic medicine)

  A304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  C905, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  C905, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  A905, Fall, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  A905, Fall, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  C905, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From Apr. 2019, To Mar. 2020

  Fundamental Chemical Experiments

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部

Administration

Faculty management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2025

  情報システム委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2025

  環境・安全衛生委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2022

  動物実験委員会　委員