Basic Information

Academic Degree

• 修士（薬科学）(大阪大学)
• 博士（医学）(大阪大学)

Research History

• From Apr. 2023, To Present

  Kyoto University, Institute for Life and Medical Sciences, Program-specific assistant professor
• From Jun. 2020, To Mar. 2023

  Kyoto University, ウイルス・再生医科学研究所, 特定助教
• From Apr. 2019, To Present

  Osaka University, IFReC, Researcher
• From Apr. 2019, To May 2020

  Kyoto University, Institute for Frontier Life and Medical Sciences, Researcher

Profile

• Profile

  自己免疫寛容を維持する機構を考えています.
  
  自己免疫疾患, Anergy, 制御性T細胞, Treg, Foxp3, CD4+Th細胞, T細胞受容体, 抗腫瘍免疫

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201901004933275850

• Researcher number

  70869114

researchmap URL

• https://researchmap.jp/kawakamiryoji

Research

Research Topics, Overview of the research

• Research Topics

  Establish and Maintenance of Immunological self-tolerance

• Overview of the research

  Immune system is a biological defense mechanism that eliminates the harmful foreign substances such as pathogenic viruses and bacteria. Nevertheless, immune system does not react to the components of the self-body or to acceptable antigens such as food, symbiotic bacteria, or the fetus. Allergy and autoimmune diseases are caused by a breakdown of this "immunological self-tolerance". I am keen to elucidate the mechanism by which immunological self-tolerance is established and maintained. I am currently focusing on regulatory T cells, which are lymphocytes with immunosuppressive properties.

Research Interests

• Foxp3
• Anergy
• Autoimmunity
• Treg

Research Areas

• Life sciences, Immunology, Immunology

Papers

• Treg cells augment self-tolerance during infection

  Ryoji Kawakami; Shimon Sakaguchi

  Nature Immunology, 10 Apr. 2025

  
• KLF2 expression in IgG plasma cells at their induction site regulates the migration program.

  Wataru Ise; Takuya Koike; Nozomi Shimada; Hiromi Yamamoto; Yuki Tai; Taiichiro Shirai; Ryoji Kawakami; Mana Kuwabara; Chie Kawai; Kyoko Shida; Takeshi Inoue; Nozomi Hojo; Kenji Ichiyama; Shimon Sakaguchi; Katsuyuki Shiroguchi; Kazuhiro Suzuki; Tomohiro Kurosaki

  The Journal of experimental medicine, 05 May 2025, Peer-reviewed

  
• Natural Treg Development in the Thymus

  Ryoji Kawakami; Yohko Kitagawa; Shimon Sakaguchi

  Reference Module in Life Sciences, Oct. 2024, Invited, Lead author

  
• Evaluation of age estimation using alveolar bone images

  Hideko Fujimoto; Kaori Kimura-Kataoka; Akiko Takeuchi; Motoo Yoshimiya; Ryoji Kawakami

  Forensic Science International, Nov. 2024, Peer-reviewed

  Access this paper :

  
• Regulatory T Cells for Control of Autoimmunity

  Ryoji Kawakami; Shimon Sakaguchi

  Advances in Experimental Medicine and Biology, 12 Mar. 2024, Peer-reviewed, Lead author

  
• Treg-based immunotherapy for antigen-specific immune suppression and stable tolerance induction: a perspective

  Shimon Sakaguchi; Ryoji Kawakami; Norihisa Mikami

  Immunotherapy Advances, 21 Apr. 2023, Peer-reviewed, Invited

  
• Therapeutic Strategy for Rheumatoid Arthritis by Induction of Myeloid-Derived Suppressor Cells with High Suppressive Potential.

  Shohei Nakano; Norihisa Mikami; Mai Miyawaki; Saho Yamasaki; Shoko Miyamoto; Mayu Yamada; Tomoya Temma; Yousuke Nishi; Arata Nagaike; Seijun Sakae; Takuya Furusawa; Ryoji Kawakami; Takumi Tsuji; Takeyuki Kohno; Yuya Yoshida

  Biological & pharmaceutical bulletin, 01 Aug. 2022

  
• Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

  Ryoji Kawakami; Yohko Kitagawa; Kelvin Y. Chen; Masaya Arai; Daiya Ohara; Yamami Nakamura; Keiko Yasuda; Motonao Osaki; Norihisa Mikami; Caleb A. Lareau; Hitomi Watanabe; Gen Kondoh; Keiji Hirota; Naganari Ohkura; Shimon Sakaguchi

  Immunity, May 2021, Peer-reviewed, Lead author

  
• New Treg cell-based therapies of autoimmune diseases: towards antigen-specific immune suppression

  Norihisa Mikami; Ryoji Kawakami; Shimon Sakaguchi

  Current Opinion in Immunology, Dec. 2020, Peer-reviewed

  
• Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

  Norihisa Mikami; Ryoji Kawakami; Kelvin Y. Chen; Atsushi Sugimoto; Naganari Ohkura; Shimon Sakaguchi

  Proceedings of the National Academy of Sciences, 02 Jun. 2020, Peer-reviewed, Lead author

  
• Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19.

  Masahiko Akamatsu; Norihisa Mikami; Naganari Ohkura; Ryoji Kawakami; Yohko Kitagawa; Atsushi Sugimoto; Keiji Hirota; Naoto Nakamura; Satoru Ujihara; Toshio Kurosaki; Hisao Hamaguchi; Hironori Harada; Guliang Xia; Yoshiaki Morita; Ichiro Aramori; Shuh Narumiya; Shimon Sakaguchi

  Science immunology, 25 Oct. 2019, Peer-reviewed

  
• Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation

  Yasuda, K.; Kitagawa, Y.; Kawakami, R.; Isaka, Y.; Watanabe, H.; Kondoh, G.; Kohwi-Shigematsu, T.; Sakaguchi, S.; Hirota, K.

  Nature Communications, Feb. 2019, Peer-reviewed

  
• Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment (vol 18, pg 173, 2017)

  Yohko Kitagawa; Naganari Ohkura; Yujiro Kidani; Alexis Vandenbon; Keiji Hirota; Ryoji Kawakami; Keiko Yasuda; Daisuke Motooka; Shota Nakamura; Motonari Kondo; Ichiro Taniuchi; Terumi Kohwi-Shigematsu; Shimon Sakaguchi

  NATURE IMMUNOLOGY, Nov. 2017, Peer-reviewed

  
• Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment

  Yohko Kitagawa; Naganari Ohkura; Yujiro Kidani; Alexis Vandenbon; Keiji Hirota; Ryoji Kawakami; Keiko Yasuda; Daisuke Motooka; Shota Nakamura; Motonari Kondo; Ichiro Taniuchi; Terumi Kohwi-Shigematsu; Shimon Sakaguchi

  NATURE IMMUNOLOGY, Feb. 2017, Peer-reviewed

  
• Transcription factors downstream of IL-4 and TGF-β signals: Analysis by quantitative PCR, Western blot, and flow cytometry

  Atsushi Sugimoto; Ryoji Kawakami; Norihisa Mikami

  Methods in Molecular Biology, 2017, Peer-reviewed

  
• ALKBH8 promotes bladder cancer growth and progression through regulating the expression of survivin

  Ikumi Ohshio; Ryoji Kawakami; Yohei Tsukada; Kazuhiro Nakajima; Kaori Kitae; Tomoki Shimanoe; Yasuka Saigo; Hiroaki Hase; Yuko Ueda; Kentaro Jingushi; Kazutake Tsujikawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2016, Peer-reviewed, Lead author

  
• miR-629 Targets TRIM33 to Promote TGF beta/Smad Signaling and Metastatic Phenotypes in ccRCC

  Kentaro Jingushi; Yuko Ueda; Kaori Kitae; Hiroaki Hase; Hiroshi Egawa; Ikumi Ohshio; Ryoji Kawakami; Yuri Kashiwagi; Yohei Tsukada; Takumi Kobayashi; Wataru Nakata; Kazutoshi Fujita; Motohide Uemura; Norio Nonomura; Kazutake Tsujikawa

  MOLECULAR CANCER RESEARCH, Mar. 2015, Peer-reviewed

  
• 泌尿器科癌PDXモデルマウスを用いた癌悪性化メカニズムの解析

  廣瀬 遼; 神宮司 健太郎; 江川 博; 川上 竜司; 塚田 陽平; 柏木 悠里; 小林 巧明; 北惠 郁緒里; 上田 裕子; 深田 宗一朗; 中田 渡; 藤田 和利; 植村 元秀; 野々村 祝夫; 辻川 和丈

  日本薬学会年会要旨集, Mar. 2015, Peer-reviewed

  
• LOXL2 Status Correlates with Tumor Stage and Regulates Integrin Levels to Promote Tumor Progression in ccRCC

  Hiroaki Hase; Kentaro Jingushi; Yuko Ueda; Kaori Kitae; Hiroshi Egawa; Ikumi Ohshio; Ryoji Kawakami; Yuri Kashiwagi; Yohei Tsukada; Takumi Kobayashi; Wataru Nakata; Kazutoshi Fujita; Motohide Uemura; Norio Nonomura; Kazutake Tsujikawa

  MOLECULAR CANCER RESEARCH, Dec. 2014, Peer-reviewed

  
• AlkB homolog8(ABH8)の膀胱癌治療分子標的としての評価 ABH8の膀胱癌におけるアポトーシス抵抗性賦与の解析

  塚田 陽平; 川上 竜司; 北惠 郁緒里; 神宮司 健太郎; 上田 裕子; 深田 宗一郎; 小西 登; 山元 弘; 辻川 和丈

  日本薬学会年会要旨集, Mar. 2014, Peer-reviewed

  
• AlkB homolog 8(ABH8)の膀胱癌治療分子標的としての評価 ABH8の膀胱癌悪性化機構の解析

  川上 竜司; 中嶋 一裕; 北惠 郁緒里; 神宮司 健太郎; 上田 裕子; 深田 宗一朗; 小西 登; 山元 弘; 辻川 和丈

  日本薬学会年会要旨集, Mar. 2013, Peer-reviewed

  
• Brazilian green propolis promotes TNFR2 expression on regulatory T cells

  Norihisa Mikami; Hiroko Tani; Ryoji Kawakami; Atsushi Sugimoto; Shimon Sakaguchi; Tomoki Ikuta

  Food Science & Nutrition, Jun. 2021, Peer-reviewed

  

Misc.

• Guidance of regulatory T cell development by Satb1-dependent super-enhancer establishment (vol 18, pg 173, 2017)

  Yohko Kitagawa; Naganari Ohkura; Yujiro Kidani; Alexis Vandenbon; Keiji Hirota; Ryoji Kawakami; Keiko Yasuda; Daisuke Motooka; Shota Nakamura; Motonari Kondo; Ichiro Taniuchi; Terumi Kohwi-Shigematsu; Shimon Sakaguchi

  NATURE IMMUNOLOGY, Apr. 2017

  

External funds: Kakenhi

• A mechanism to generate the stably suppressive regulatory T cells

  Grant-in-Aid for Early-Career Scientists

  Basic Section 49070:Immunology-related

  Kyoto University

  Ryoji Kawakami

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  免疫寛容;制御性T細胞;Treg;エンハンサー;CRISPR/Cas9;Foxp3;Treg-DR;エピジェネティクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K16279/
• 胸腺自己反応性T細胞の制御性T細胞系譜への運命決定機構解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49070:Immunology-related

  Kyoto University

  川上 竜司

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  免疫寛容;制御性T細胞;Treg

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02733/
• Development of periodontal disease image examination method using landmark detection on alveolar bone images by deep learning

  Grant-in-Aid for Scientific Research (C)

  Basic Section 57080:Social dentistry-related

  Kyoto University

  藤本 秀子

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  歯槽骨画像;深層学習;歯槽骨吸収;歯周病画像検査;特徴点検出

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K09501/
• 胸腺自己反応性T細胞の制御性T細胞系譜への運命決定機構解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49070:Immunology-related

  Kyoto University

  川上 竜司

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  免疫寛容;制御性T細胞;Treg

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27424/

Administration

Faculty management (title, position)

• From 01 Apr. 2023

  共同利用機器等委員会　委員
• From 01 Apr. 2023

  化学物質管理委員会　委員