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Kiuchi, Tai
Graduate School of Medicine, Medicine Program-Specific Associate Professor
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Last Updated :2025/06/20
Basic Information
Faculty
Academic Degree
Academic Resume (Graduate Schools)
Academic Resume (Undergraduate School/Majors)
Research History
- From Feb. 2015, To PresentKyoto University, Graduate School of Medicine, 准教授
- From Jul. 2014, To Jan. 2015Kyoto University, Graduate School of Medicine, 助教
- From Apr. 2011, To Jun. 2014Tohoku University Graduate School of Life Sciences, Department of Biomolecular Sciences, Division of Molecular Biosystems,Laboratory of Single-Molecule Cell Biology, Assistant Professor
- From Mar. 2008, To Mar. 2011King's College London, Richard Dimbleby Department of Cancer Research, Randall Division of Cell and Molecular Biophysics, Postdoctoral Research Associate
- From Apr. 2006, To Feb. 2008Tohoku University, Graduate School of Medicine, COEフェロー
- From Jul. 2004, To Mar. 2006Tohoku University, Graduate School of Life Sciences, 博士研究員
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Researcher number
70443984External link
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Last Updated :2025/06/20
Research
Research Interests
Research Areas
Papers
- Engineered fast-dissociating antibody fragments for multiplexed super-resolution microscopy.Qianli Zhang; Akitoshi Miyamoto; Shin Watanabe; Takao Arimori; Masanori Sakai; Madoka Tomisaki; Tai Kiuchi; Junichi Takagi; Naoki WatanabeCell reports methods, 24 Oct. 2022
- Convection-Induced Biased Distribution of Actin Probes in Live CellsYamashiro S; Taniguchi D; Tanaka S; Kiuchi T; Vavylonis D; Watanabe NBiophysical Journal, Jan. 2019, Peer-reviewed
- Multitarget super-resolution microscopy with high-density labeling by exchangeable probesTai Kiuchi; Makio Higuchi; Akihiro Takamura; Masahiro Maruoka; Naoki WatanabeNATURE METHODS, Aug. 2015, Peer-reviewed
- The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motilityTai Kiuchi; Elena Ortiz-Zapater; James Monypenny; Daniel R. Matthews; Lan K. Nguyen; Jody Barbeau; Oana Coban; Katherine Lawler; Brian Burford; Daniel J. Rolfe; Emanuele de Rinaldis; Dimitra Dafou; Michael A. Simpson; Natalie Woodman; Sarah Pinder; Cheryl E. Gillett; Viviane Devauges; Simon P. Poland; Gilbert Fruhwirth; Pierfrancesco Marra; Ykelien L. Boersma; Andreas Plueckthun; William J. Gullick; Yosef Yarden; George Santis; Martyn Winn; Boris N. Kholodenko; Marisa L. Martin-Fernandez; Peter Parker; Andrew Tutt; Simon M. Ameer-Beg; Tony NgSCIENCE SIGNALING, Aug. 2014, Peer-reviewed
- New single-molecule speckle microscopy reveals modification of the retrograde actin flow by focal adhesions at nanometer scalesSawako Yamashiro; Hiroaki Mizuno; Matthew B. Smith; Gillian L. Ryan; Tai Kiuchi; Dimitrios Vavylonis; Naoki WatanabeMOLECULAR BIOLOGY OF THE CELL, Apr. 2014, Peer-reviewed
- CaMKII beta-mediated LIM-kinase activation plays a crucial role in BDNF-induced neuritogenesisAkihiko Saito; Ken Miyajima; Junichi Akatsuka; Hiroshi Kondo; Toshiya Mashiko; Tai Kiuchi; Kazumasa Ohashi; Kensaku MizunoGENES TO CELLS, Jul. 2013, Peer-reviewed
- Molecular viewing of actin polymerizing actions and beyond: Combination analysis of single-molecule speckle microscopy with modeling, FRAP and s-FDAP (sequential fluorescence decay after photoactivation)Naoki Watanabe; Sawako Yamashiro; Dimitrios Vavylonis; Tai KiuchiDevelopment Growth and Differentiation, May 2013, Peer-reviewed, Invited
- F-and G-actin homeostasis regulates mechanosensitive actin nucleation by forminsChiharu Higashida; Tai Kiuchi; Yushi Akiba; Hiroaki Mizuno; Masahiro Maruoka; Shuh Narumiya; Kensaku Mizuno; Naoki WatanabeNature Cell Biology, Apr. 2013, Peer-reviewed
- Distributed actin turnover in the lamellipodium and FRAP kineticsMatthew B. Smith; Tai Kiuchi; Naoki Watanabe; Dimitrios VavylonisBiophysical Journal, 08 Jan. 2013, Peer-reviewed
- Visualization of cofilin-actin and Ras-Raf interactions by bimolecular fluorescence complementation assays using a new pair of split Venus fragmentsKazumasa Ohashi; Tai Kiuchi; Kazuyasu Shoji; Kaori Sampei; Kensaku MizunoBIOTECHNIQUES, Jan. 2012, Peer-reviewed
- LIM Kinase Has a Dual Role in Regulating Lamellipodium Extension by Decelerating the Rate of Actin Retrograde Flow and the Rate of Actin PolymerizationKazumasa Ohashi; Sachiko Fujiwara; Takuya Watanabe; Hiroshi Kondo; Tai Kiuchi; Masaaki Sato; Kensaku MizunoJOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2011, Peer-reviewed
- Live-cell imaging of G-actin dynamics using sequential FDAP.Kiuchi T; Nagai T; Ohashi K; Watanabe N; Mizuno KBioarchitecture, Sep. 2011, Peer-reviewed, Invited
- Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extensionTai Kiuchi; Tomoaki Nagai; Kazumasa Ohashi; Kensaku MizunoJOURNAL OF CELL BIOLOGY, Apr. 2011, Peer-reviewed
- LIM-kinase-mediated cofilin phosphorylation decelerates actin retrograde flow in lamellipodiaK. Ohashi; S. Fujiwara; T. Watanabe; T. Kiuchi; M. Sato; K. MizunoJournal of Biological Chemistry, 2011, Peer-reviewed
- The challenges of integrating molecular imaging into the optimization of cancer therapyG. S. Patel; T. Kiuchi; K. Lawler; E. Ofo; G. O. Fruhwirth; M. Kelleher; E. Shamil; R. Zhang; P. R. Selvin; G. Santis; J. Spicer; N. Woodman; C. E. Gillett; P. R. Barber; B. Vojnovic; G. Keri; T. Schaeffter; V. Goh; M. J. O'Doherty; P. A. Ellisb; T. NgINTEGRATIVE BIOLOGY, 2011, Peer-reviewed, Invited
- 2SH0935 Critical role of actin monomer concentration in stimulus induced actin assembly and cell extension(2SH Actin as a Cytomotive Filament,The 48th Annual Meeting of the Biophysical Society of Japan)Kiuchi Tai; Mizuno KensakuSeibutsu Butsuri, 2010
- The SUMO modification pathway is involved in the BRCA1 response to genotoxic stressJoanna R. Morris; Chris Boutell; Melanie Keppler; Ruth Densham; Daniel Weekes; Amin Alamshah; Laura Butler; Yaron Galanty; Laurent Pangon; Tai Kiuchi; Tony Ng; Ellen SolomonNATURE, Dec. 2009, Peer-reviewed
- An Unbiased Screen Identifies DEP-1 Tumor Suppressor as a Phosphatase Controlling EGFR EndocytosisGabi Tarcic; Shlomit K. Boguslavsky; Jean Wakim; Tai Kiuchi; Angela Liu; Felicia Reinitz; David Nathanson; Takamune Takahashi; Paul S. Mischel; Tony Ng; Yosef YardenCURRENT BIOLOGY, Nov. 2009, Peer-reviewed
- Analysis of the regulation of actin cytoskeleton dynamics using dronpa, a photochromic fluorescent proteinKazumasa Ohashi; Tai Kiuchi; Tomoaki Nagai; Kensaku Mizuno2008 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2008, 2008, Peer-reviewed
- Cofilin promotes stimulus-induced lamellipodium formation by generating an abundant supply of actin monomersTai Kiuchi; Kazumasa Ohashi; Souichi Kurita; Kensaku MizunoJOURNAL OF CELL BIOLOGY, May 2007, Peer-reviewed
Misc.
- 多重染色・高密度標識で従来法の壁を越えるIRIS超解像蛍光顕微鏡法渡邊 直樹; 木内 泰生体の科学, Oct. 2017, Invited
- 細胞生物学とイメージング技術の共鳴誘導 高密度・多重染色超解像顕微鏡法IRISの3次元イメージングへの発展木内 泰; 渡邊 直樹日本細胞生物学会大会講演要旨集, May 2017
- 分子から個体まで神経系を見る 分子の窓を通して覗いた細胞の構造としくみ渡邊 直樹; 木内 泰; 山城 佐和子バイオイメージング, Aug. 2016
- 超解像顕微鏡法IRISの開発による無制限多重染色と高精細な画質の実現木内 泰; 渡邊 直樹感染・炎症・免疫, Jul. 2016, Invited
- 高密度・多重染色超解像蛍光顕微鏡法IRISの原理と実践木内 泰; 渡邊 直樹生体の科学, Jun. 2016, Invited
- 細胞生物学に役に立つ最新技術の展開 多重高密度標識超解像顕微鏡IRISとその応用渡邊 直樹; 三好 拓志; 三宅 崇文; 佐々木 瞭; 木内 泰日本細胞生物学会大会講演要旨集, May 2016
- Multitarget super-resolution microscopy with high-density labeling by exchangeable probes (vol 12, pg 743, 2015)Tai Kiuchi; Makio Higuchi; Akihiro Takamura; Masahiro Maruoka; Naoki WatanabeNATURE METHODS, Sep. 2015
- 蛍光単分子可視化と他の分子動態解析法の融合による細胞内アクチン重合機構の解明渡邊 直樹; 木内 泰顕微鏡, Jun. 2013, Invited
- Dronpaを用いたアクチン動態のライブイメージング木内 泰; 水野健作実験医学増刊, Oct. 2008, Invited
- Slingshot regulates primary dendrite formation in rat hippocampal neuronsJunichi Akatsuka; Tai Kiuchi; Mitsuharu Endo; Kazumasa Ohashi; Kensaku MizunoNEUROSCIENCE RESEARCH, 2007
Industrial Property Rights
- 特許US 10,858,688 B2, 特願15/696,089, OBSERVATION METHOD USING BINDING AND DISSOCIATION PROBEKIUCHI Tai; Watanabe Naoki
- 特許6422172, 結合解離プローブを用いた観察方法木内 泰; 渡邊 直樹; 三好 拓志; 佐々木 瞭
- 特願16761865.1, OBSERVATION METHOD USING BOND DISSOCIATION PROBEKIUCHI Tai; Watanabe Naoki; MIYOSHI Takushi; SASAKI Ryo
Awards
External funds: Kakenhi
- Multicolor super-resolution mapping of endogenous proteins involved in receptor endocytosisGrant-in-Aid for Scientific Research (C)Basic Section 44010:Cell biology-relatedKyoto UniversityTai KiuchiFrom 01 Apr. 2021, To 31 Mar. 2024, Project Closed超解像顕微鏡法;エンドサイトーシス;EGF受容体;クラスリン;超解像イメージング
- 多重染色超解像顕微鏡法による細胞内シグナル伝達の空間マップの作成Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)Complex systemsKyoto University木内 泰From 01 Apr. 2019, To 31 Mar. 2021, Project Closed細胞内シグナル伝達;超解像イメージング;細胞骨格;EGF受容体;超解像顕微鏡法
- The spatial patterning mechanisms of cytoskeletons during cancer cell invasion analyzed by 3D multitarget super-resolution imagingGrant-in-Aid for Scientific Research (C)Kyoto UniversityTai KiuchiFrom 01 Apr. 2017, To 31 Mar. 2020, Project Closed超解像顕微鏡法;アクチン;細胞骨格;３次元イメージング;がん浸潤;アクチン骨格;細胞移動
- 細胞内でのタンパク質複合体の多重染色超解像イメージングGrant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)Complex systemsKyoto University木内 泰From 01 Apr. 2015, To 31 Mar. 2017, Project Closed超解像顕微鏡;タンパク質複合体;超解像顕微鏡法;細胞骨格;接着斑
- The spatial patterning mechanisms of cytoskeletons and focal adhesions analyzed by multitarget super-resolution microscopyGrant-in-Aid for Scientific Research (C)Kyoto UniversityTai KiuchiFrom 01 Apr. 2014, To 31 Mar. 2017, Project Closed細胞骨格;超解像顕微鏡;超解像顕微鏡法;接着斑;超解像イメージング;アクチン;微小管;中間径フィラメント
- Self-assembly mechanism for rearrangement of actin cytoskeleton in cell polarizationGrant-in-Aid for Young Scientists (B)Tohoku UniversityTAI KIUCHIFrom 01 Apr. 2012, To 31 Mar. 2014, Project Closedバイオイメージング;アクチン細胞骨格;アクチンダイナミクス;アクチン
- Clathrin被覆部位でのHERを基点としたメゾ複雑体の機能解析Grant-in-Aid for Transformative Research Areas (A)Transformative Research Areas, Section (III)Kyoto University木内 泰From 07 Jun. 2024, To 31 Mar. 2026, Granted超解像顕微鏡イメージング;超解像顕微鏡法;エンドサイトーシス;細胞内シグナル伝達
