Researchers Information System

日本語に切り替えるswitch to english

Maruoka, Masahiro

Institute for Advanced Study Program-Specific Senior Lecturer/Program-Specific Junior Associate Professor

Maruoka, Masahiro
list
    Last Updated :2025/01/21

    Basic Information

    Professional Memberships

    • 日本生化学会
    • JAPAN SOCIETY FOR CELL BIOLOGY
    • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
    • 日本Cell Death学会

    Academic Degree

    • 修士(バイオサイエンス)(奈良先端科学技術大学院大学)
    • 博士(バイオサイエンス)(奈良先端科学技術大学院大学)

    Research History

    • From Apr. 2008, To Mar. 2010
      Japan Society for the Promotion of Science, 特別研究員(DC2)
    • From May 2024, To Present
      Kyoto University, iCeMS, 特定講師
    • From Feb. 2017, To Apr. 2024
      Kyoto University, Institute for Integrated Cell-Material Sciences, 特定助教
    • From Apr. 2016, To Jan. 2017
      RIKEN, Researcher
    • From Apr. 2014, To Mar. 2016
      Kobe University, Graduate School of Medicine, 特命助教
    • From Jul. 2010, To Mar. 2014
      Tohoku University, Graduate School of Life Sciences, 研究教育支援者
    • From Apr. 2009, To Jun. 2010
      Kyoto University, Graduate School of Medicine

    Profile

    • Profile

      2008年 日本学術振興会 特別研究員 (DC2) 


      2009年 奈良先端科学技術大学院大学 博士後期課程 修了 


      2009年 京都大学 医学研究科 


      2010年 東北大学 生命科学研究科 研究教育支援者


      2014年 神戸大学 医学研究科 特命助教 


      2017年 京都大学 物質―細胞統合システム拠点 特定助教

    ID,URL

    researchmap URL

    list
      Last Updated :2025/01/21

      Research

      Research Topics, Overview of the research

      • Research Topics

        Analysis of the membrane dynamics and its physiological role

      Research Interests

      • リン脂質スクランブリング
      • 細胞骨格

      Research Areas

      • Life sciences, Functional biochemistry
      • Life sciences, Molecular biology

      Papers

      • Protocol for in vivo CRISPR screening targeting murine testicular cells.
        Yuki Noguchi; Masahiro Maruoka; Jun Suzuki
        STAR protocols, 11 Sep. 2024, Peer-reviewed
      • Phospholipid scrambling induced by an ion channel/metabolite transporter complex.
        Han Niu; Masahiro Maruoka; Yuki Noguchi; Hidetaka Kosako; Jun Suzuki
        Nature communications, 31 Aug. 2024, Peer-reviewed
      • In vivo CRISPR screening directly targeting testicular cells.
        Yuki Noguchi; Yasuhito Onodera; Tatsuo Miyamoto; Masahiro Maruoka; Hidetaka Kosako; Jun Suzuki
        Cell genomics, 27 Feb. 2024, Peer-reviewed
      • Extracellular calcium functions as a molecular glue for transmembrane helices to activate the scramblase Xkr4
        Panpan Zhang; Masahiro Maruoka; Ryo Suzuki; Hikaru Katani; Yu Dou; Daniel M. Packwood; Hidetaka Kosako; Motomu Tanaka; Jun Suzuki
        Nature Communications, 11 Sep. 2023, Peer-reviewed
      • Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane.
        Masahiro Maruoka; Panpan Zhang; Hiromi Mori; Eiichi Imanishi; Daniel M Packwood; Hiroshi Harada; Hidetaka Kosako; Jun Suzuki
        Molecular cell, 01 Apr. 2021, Peer-reviewed, Lead author
      • Paradoxical activation of c-Src as a drug-resistant mechanism.
        Makio Higuchi; Kenichi Ishiyama; Masahiro Maruoka; Ryosuke Kanamori; Akifumi Takaori-Kondo; Naoki Watanabe
        Cell reports, 23 Mar. 2021, Peer-reviewed
      • Regulation of phospholipid dynamics in brain.
        Masahiro Maruoka; Jun Suzuki
        Neuroscience research, 18 Jan. 2021, Peer-reviewed, Lead author
      • Roles of the third Ig-like domain of Necl-5/PVR and the fifth Ig-like domain of the PDGF receptor in its signaling
        Yuki Ueda; Shin Kedashiro; Masahiro Maruoka; Kiyohito Mizutani; Yoshimi Takai
        Genes to Cells, 01 Mar. 2018, Peer-reviewed
      • Nectin-like molecule-4/cell adhesion molecule 4 inhibits the ligand-induced dimerization of ErbB3 with ErbB2
        Kiyohito Mizutani; Shin Kedashiro; Masahiro Maruoka; Yuki Ueda; Yoshimi Takai
        SCIENTIFIC REPORTS, Sep. 2017, Peer-reviewed
      • Nectin-4 co-stimulates the prolactin receptor by interacting with SOCS1 and inhibiting its activity on the JAK2-STAT5a signaling pathway
        Masahiro Maruoka; Shin Kedashiro; Yuki Ueda; Kiyohito Mizutani; Yoshimi Takai
        JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2017, Peer-reviewed, Lead author
      • A Novel Nectin-mediated Cell Adhesion Apparatus That Is Implicated in Prolactin Receptor Signaling for Mammary Gland Development
        Midori Kitayama; Kiyohito Mizutani; Masahiro Maruoka; Kenji Mandai; Shotaro Sakakibara; Yuki Ueda; Takahide Komori; Yohei Shimono; Yoshimi Takai
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2016, Peer-reviewed, Lead author
      • Multitarget super-resolution microscopy with high-density labeling by exchangeable probes
        Tai Kiuchi; Makio Higuchi; Akihiro Takamura; Masahiro Maruoka; Naoki Watanabe
        NATURE METHODS, Aug. 2015, Peer-reviewed
      • F-and G-actin homeostasis regulates mechanosensitive actin nucleation by formins
        Chiharu Higashida; Tai Kiuchi; Yushi Akiba; Hiroaki Mizuno; Masahiro Maruoka; Shuh Narumiya; Kensaku Mizuno; Naoki Watanabe
        Nature Cell Biology, Apr. 2013, Peer-reviewed
      • Functional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.
        Mizuho Sato; Masahiro Maruoka; Tatsuo Takeya
        Journal of signal transduction, 17 May 2012, Peer-reviewed
      • Siglec-15 Protein Regulates Formation of Functional Osteoclasts in Concert with DNAX-activating Protein of 12 kDa (DAP12)
        Norihiro Ishida-Kitagawa; Kunitaro Tanaka; Xilinqiqige Bao; Takanori Kimura; Tadashi Miura; Yoshiki Kitaoka; Kouhei Hayashi; Mizuho Sato; Masahiro Maruoka; Takuya Ogawa; Jun Miyoshi; Tatsuo Takeya
        JOURNAL OF BIOLOGICAL CHEMISTRY, May 2012, Peer-reviewed
      • Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukaemic cell adhesion
        Masahiro Maruoka; Mizuho Sato; Yunfeng Yuan; Masayoshi Ichiba; Ryosuke Fuji; Takuya Ogawa; Norihiro Ishida-Kitagawa; Tatsuo Takeya; Naoki Watanabe
        BIOCHEMICAL JOURNAL, Feb. 2012, Peer-reviewed, Lead author, Corresponding author
      • Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1
        Mizuho Sato; Masahiro Maruoka; Naohiko Yokota; Masayoshi Kuwano; Akira Matsui; Mika Inada; Takuya Ogawa; Norihiro Ishida-Kitagawa; Tatsuo Takeya
        FEBS LETTERS, Mar. 2011, Peer-reviewed, Lead author, Corresponding author
      • A rapid protein expression and purification system in Chinese hamster ovary cells using flow cytometry
        SUZUKI Jun; MARUOKA Masahiro; KAWATA Shigehisa; SHISHIDO Tomoyuki
        Cytometry Research, 25 Mar. 2007
      • A rapid protein expression and purification system using Chinese hamster ovary cells expressing retrovirus receptor
        Jun Suzuki; Machi Fukuda; Shigehisa Kawata; Masahiro Maruoka; Yoko Kubo; Tatsuo Takeya; Tomoyuki Shishido
        JOURNAL OF BIOTECHNOLOGY, Dec. 2006, Peer-reviewed
      • Retrovirus-mediated conditional immortalization and analysis of established cell lines of osteoclast precursor cells
        Shigehisa Kawata; Jun Suzuki; Masahiro Maruoka; Megumi Mizutamari; Norihiro Ishida-Kitagawa; Kelichiro Yogo; Parmjit S. Jat; Tomoyuki Shishido
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2006, Peer-reviewed
      • NESH (Abi-3) is pre-sent in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation
        Noriko Hirao; Seiichi Sato; Tetsuya Gotoh; Masahiro Maruoka; Jun Suzuki; Satoru Matsuda; Tornoyuki Shishido; Katsuko Tani
        FEBS LETTERS, Nov. 2006, Peer-reviewed
      • Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases
        M Maruoka; J Suzuki; S Kawata; K Yoshida; N Hirao; S Sato; SP Goff; T Takeya; K Tani; T Shishido
        FEBS LETTERS, Jun. 2005, Peer-reviewed, Lead author

      Misc.

      • Unbiased screening based on the function
        圓岡真宏, 鈴木淳
        臨床免疫・アレルギー科, 25 Feb. 2023, Peer-reviewed, Lead author
      • 【脳神経回路のダイナミクスから探る脳の発達・疾患・老化】不要シナプスのコンパートメント化と認識・除去
        圓岡 真宏; 鈴木 淳
        生体の科学, Feb. 2019
      • Update Review アクチン研究の最新動向 構造から調節、恒常性、可視化、モデリングまで
        山城 佐和子; 圓岡 真宏; 水野 裕昭; 渡邊 直樹
        実験医学, Nov. 2012
      • Inhibitor induced conformational modulation of target kinases
        Naoki Watanabe; Yunfeng Yuan; Masahiro Maruoka
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012
      • Bcr‐AblによるVASPのチロシンリン酸化は白血病細胞における接着能の亢進に関与する
        圓岡真宏; YUAN Yunfeng; 渡邊直樹
        生化学, 2010

      Presentations

      • Regulation of Membrane Lipid Dynamics by Scramblase Xkr4
        圓岡真宏; Panpan Zhang; 蚊谷光; 鈴木淳
        MBSJ2023, 07 Dec. 2023, Invited
      • Regulation of scramblase Xkr4 on the plasma membrane by its interaction with the organelle.
        圓岡 真宏; 下村 真由; Zhang Panpan; 鈴木 淳
        第95回 日本生化学会大会, 09 Nov. 2022, Invited
      • Regulatory mechanism and role of scramblase Xkr4
        Masahiro Maruoka; Panpan Zhang; Jun Suzuki
        The 74th Annual Meeting of the Japan Society for Cell Biology, 30 Jun. 2022, Invited
      • スクランブラーゼXkr4の活性制御機構
        圓岡真宏; Panpan; Zhang 鈴木淳
        第29回Cell death学会学術集会, 26 Jul. 2021, Invited
      • ctin-4 stimulates prolactin receptor signaling by preventing SOCS1-mediated feedback inhibition during the development of mammary gland
        Masahiro Maruoka
        ConBio2017, 08 Dec. 2017
      • 乳腺分化における細胞間接着分子ネクチンの機能
        圓岡 真宏; 水谷; 清人; 慶田城; 迅; 高井 義美
        日本生化学会 近畿支部例会, 27 May 2017
      • FUNCTIONAL ANALYSIS OF NECTINS IN MOUSE SUBMANDIBULAR GLANDS
        Masahiro Maruoka
        23rd international Conference on Oral and Maxillofacial Surgery, 01 Apr. 2017

      Books and Other Publications

      • Adaptor Proteins and Cancer
        Tomoyuki Shishido; Mizuho Sato; Masahiro Maruoka; Katsuko Tani, Joint work, Abelson interactor (Abi) family proteins and cancer.
        Transworld research network, 2008
      • 核内タンパク質によるスクランブラーゼの活性制御
        圓岡真宏; Panpan Zhang; 鈴木 淳, Joint work
        生化学, Apr. 2022
      • 不要細胞における“eat-me”シグナルの露出に関与する DNA修復タンパク質 XRCC4 の新たな役割
        圓岡真宏、Panpan Zhang, 鈴木 淳, Joint work
        実験医学, 2021

      Industrial Property Rights

      • 特願2020-178281, Xkr4ポリペプチド、XRCC4ポリペプチド、および目的とする表現型に対応する遺伝子を特定する方法
        鈴木淳; 圓岡真宏; Panpan Zhang

      External funds: Kakenhi

      • Analysis of the regulatory mechanism of Xkr4 scramblase activity
        Grant-in-Aid for Scientific Research (C)
        Basic Section 43010:Molecular biology-related
        Kyoto University
        Masahiro Maruoka
        From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
        スクランブラーゼ;リン脂質;Xkr4;"eat-me" signal;CRISPR;XRCC4;CRIPSR
      • pHストレス適応を司るpH誘導型転写因子の実体解明
        Grant-in-Aid for Transformative Research Areas (B)
        Transformative Research Areas, Section (III)
        Kyoto University
        高橋 重成
        From 02 Oct. 2020, To 31 Mar. 2023, Granted
        pHストレス適応;転写因子;がん;pH適応;ストレス感知;TRPチャネル
      • Identification and functional analysis of a novel Nectin-mediated cell-adhesion apparatus
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Masahiro Maruoka
        From 01 Apr. 2016, To 31 Mar. 2018, Project Closed
        ネクチン;細胞間接着;シグナル伝達
      • Establishment of a comprehensive screening system to elucidate the regulatory mechanism of scramblase Xkr4.
        Grant-in-Aid for Scientific Research (C)
        Basic Section 43010:Molecular biology-related
        Kyoto University
        圓岡 真宏
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        スクランブラーゼ;リン脂質;Xkr4;"eat-me" signal;CRISPR
      list
        Last Updated :2025/01/21

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Molecule cellular biology
          8009, Fall, Faculty of Medicine, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Molecule cellular biology
          8009, Fall, Faculty of Medicine, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Molecule cellular biology
          8009, Fall, Faculty of Medicine, 2

        ページ上部へ戻る