Basic Information

Faculty

• Faculty of Medicine
• 医学部

Academic Degree

• 修士(京都大学)
• 博士(京都大学)

ID,URL

• J-Global ID

  201401026682275534

Research

Research Areas

• Life sciences, Tumor biology

Papers

• Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.

  Shoko Ito; Keisuke Kuromiya; Miho Sekai; Hiroaki Sako; Kazuhito Sai; Riho Morikawa; Yohei Mukai; Yoko Ida; Moe Anzai; Susumu Ishikawa; Kei Kozawa; Takanobu Shirai; Nobuyuki Tanimura; Kenta Sugie; Junichi Ikenouchi; Motoyuki Ogawa; Isao Naguro; Hidenori Ichijo; Yasuyuki Fujita

  Proceedings of the National Academy of Sciences of the United States of America, 24 Oct. 2023

  
• Basal extrusion of single-oncogenic mutant cells induces dome-like structures with altered microenvironments.

  Takanobu Shirai; Miho Sekai; Kei Kozawa; Nanami Sato; Nobuyuki Tanimura; Shunsuke Kon; Tomohiro Matsumoto; Takeru Murakami; Shoko Ito; Andrew Tilston-Lunel; Xaralabos Varelas; Yasuyuki Fujita

  Cancer science, Nov. 2022, Lead author

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• Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells

  Keisuke Kuromiya; Kana Aoki; Kojiro Ishibashi; Moe Yotabun; Miho Sekai; Nobuyuki Tanimura; Sayuri Iijima; Susumu Ishikawa; Tomoko Kamasaki; Yuki Akieda; Tohru Ishitani; Takashi Hayashi; Satoshi Toda; Koji Yokoyama; Chol Gyu Lee; Ippei Usami; Haruki Inoue; Ichigaku Takigawa; Estelle Gauquelin; Kaoru Sugimura; Naoya Hino; Yasuyuki Fujita

  Cell Reports, Jul. 2022

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• The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epithelia

  Kei Kozawa; Miho Sekai; Kenji Ohba; Shoko Ito; Hiroaki Sako; Takeshi Maruyama; Mai Kakeno; Takanobu Shirai; Keisuke Kuromiya; Tomoko Kamasaki; Koki Kohashi; Shinya Tanaka; Susumu Ishikawa; Nanami Sato; Shota Asano; Hironori Suzuki; Nobuyuki Tanimura; Yohei Mukai; Noriko Gotoh; Mishie Tanino; Shinya Tanaka; Ken Natsuga; Tomoyoshi Soga; Tomonori Nakamura; Yukihiro Yabuta; Mitinori Saitou; Takahiro Ito; Kenkyo Matsuura; Makoto Tsunoda; Toyone Kikumori; Tadashi Iida; Yasuyuki Mizutani; Yuki Miyai; Kozo Kaibuchi; Atsushi Enomoto; Yasuyuki Fujita

  Current Biology, Jul. 2021, Lead author

  
• An improved clonogenic culture method for thymic epithelial cells.

  Sekai M; Wang J; Minato N; Hamazaki Y

  Journal of immunological methods, Apr. 2019, Lead author

  
• Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus

  Jianwei Wang; Miho Sekai; Takeshi Matsui; Yosuke Fujii; Mitsuru Matsumoto; Osamu Takeuchi; Nagahiro Minato; Yoko Hamazaki

  International Immunology, 05 Mar. 2019

  
• Clonogenic Culture of Mouse Thymic Epithelial Cells.

  Sekai M; Wang J; Hamazaki Y

  Methods in molecular biology (Clifton, N.J.), 2019, Lead author

  
• Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4(+) T Cells

  Kyosuke Sato; Aiko Kato; Miho Sekai; Yoko Hamazaki; Nagahiro Minato

  JOURNAL OF IMMUNOLOGY, Jul. 2017

  
• A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production

  Izumi Ohigashi; Yuki Ohte; Kazuya Setoh; Hiroshi Nakase; Akiko Maekawa; Hiroshi Kiyonari; Yoko Hamazaki; Miho Sekai; Tetsuo Sudo; Yasuharu Tabara; Hiromi Sawai; Yosuke Omae; Rika Yuliwulandari; Yasuhito Tanaka; Masashi Mizokami; Hiroshi Inoue; Masanori Kasahara; Nagahiro Minato; Katsushi Tokunaga; Keiji Tanaka; Fumihiko Matsuda; Shigeo Murata; Yousuke Takahama

  JCI Insight, 18 May 2017

  
• Obesity accelerates T cell senescence in murine visceral adipose tissue

  Kohsuke Shirakawa; Xiaoxiang Yan; Ken Shinmura; Jin Endo; Masaharu Kataoka; Yoshinori Katsumata; Tsunehisa Yamamoto; Atsushi Anzai; Sarasa Isobe; Naohiro Yoshida; Hiroshi Itoh; Ichiro Manabe; Miho Sekai; Yoko Hamazaki; Keiichi Fukuda; Nagahiro Minato; Motoaki Sano

  JOURNAL OF CLINICAL INVESTIGATION, Dec. 2016

  
• Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involution

  Yoko Hamazaki; Miho Sekai; Nagahiro Minato

  IMMUNOLOGICAL REVIEWS, May 2016

  
• Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitors

  Song Baik; Miho Sekai; Yoko Hamazaki; William E. Jenkinson; Graham Anderson

  EUROPEAN JOURNAL OF IMMUNOLOGY, Apr. 2016, Peer-reviewed

  
• Medullary Thymic Epithelial Stem Cells Maintain a Functional Thymus to Ensure Lifelong Central T Cell Tolerance

  Sekai M; HAMAZAKI Y; Minato N

  Immunity, Nov. 2014, Lead author

  
• Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors

  Miho Sekai; Shizue Tani-ichi; Mitsutoshi Yoneyama; Takashi Fujita; Tatsuo Kina; Koichi Ikuta

  Molecular Immunology, Jul. 2013, Lead author

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• Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency

  Hiroki Tanaka; Akitoshi Tamura; Miho Sekai; Yoko Hamazaki; Nagahiro Minato

  CANCER SCIENCE, Apr. 2011

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• Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells

  Yoshinori Katayama; Miho Sekai; Masakazu Hattori; Ichiro Miyoshi; Yoko Hamazaki; Nagahiro Minato

  BLOOD, Aug. 2009

  

Presentations

• 膵発がんメカニズム解明に基づく超早期がん病変の診断と予防的治療法の開発

  瀨海 美穂

  第76回日本細胞生物学会大会, 17 Jul. 2024, Invited

  
• Identification of a novel precancerous lesion ‘dome-like structure’ in mice and humans

  瀨海 美穂

  Rise of Diversity in Science Symposium, 28 Sep. 2023, Invited

  
• Identification of novel precancerous lesions ‘Dome-like structure’

  瀨海 美穂

  Japan-China Interaction meeting, 26 Jun. 2023, Invited

  
• Basal extrusion of single-oncogenic mutant cells induces dome-like structures with macrophage accumulation

  瀨海 美穂

  第23回 日本抗加齢医学会総会, 10 Jun. 2023, Invited

  
• 胸腺の髄質上皮幹細胞の同定と加齢変化

  瀨海 美穂

  日中若手行政官と異分野研究者交流シンポジウム, 15 Nov. 2017, Invited

  

Books and Other Publications

• Ｔ細胞の中枢性自己寛容を生涯にわたり保証する胸腺髄質上皮幹細胞の同定

  瀨海 美穂; 濱崎洋子; 湊長博

  ライフサイエンス新着論文レビュー 大学共同利用機関法人 情報・システム研究機構 ライフサイエンス統合データベースセンター, Jan. 2015, Not refereed

  

External funds: Kakenhi

• Understanding for the mechanism of thymic involution during aging

  Grant-in-Aid for Early-Career Scientists

  Basic Section 49070:Immunology-related

  Kyoto University;Hokkaido University

  Miho Sekai

  From 01 Apr. 2019, To 31 Mar. 2023, Project Closed

  胸腺;免疫;退縮

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16689/
• Understanding the mechanisms of the maintenance and invlution of thymus

  Grant-in-Aid for Young Scientists (B)

  Hokkaido University;Kyoto University

  Miho Sekai

  From 01 Apr. 2015, To 31 Mar. 2020, Project Closed

  胸腺;上皮細胞;幹細胞;上皮幹細胞;コロニー形成能;免疫;胸腺上皮細胞;コロニー;胸腺上皮幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K19125/

Administration

Faculty management (title, position)

• From 01 Apr. 2014, To 31 Mar. 2019

  医学図書館図書連絡委員会
• From 01 Apr. 2017, To 31 Mar. 2019

  動物実験施設運営委員会委員