瀨海 美穂
セカイ ミホ医学研究科 医学専攻分子生体統御学講座分子腫瘍学 助教
list
Last Updated :2025/05/02
研究
研究分野
論文
- Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells.Shoko Ito; Keisuke Kuromiya; Miho Sekai; Hiroaki Sako; Kazuhito Sai; Riho Morikawa; Yohei Mukai; Yoko Ida; Moe Anzai; Susumu Ishikawa; Kei Kozawa; Takanobu Shirai; Nobuyuki Tanimura; Kenta Sugie; Junichi Ikenouchi; Motoyuki Ogawa; Isao Naguro; Hidenori Ichijo; Yasuyuki FujitaProceedings of the National Academy of Sciences of the United States of America, 2023年10月24日
- Basal extrusion of single-oncogenic mutant cells induces dome-like structures with altered microenvironments.Takanobu Shirai; Miho Sekai; Kei Kozawa; Nanami Sato; Nobuyuki Tanimura; Shunsuke Kon; Tomohiro Matsumoto; Takeru Murakami; Shoko Ito; Andrew Tilston-Lunel; Xaralabos Varelas; Yasuyuki FujitaCancer science, 2022年11月, 筆頭著者
- Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cellsKeisuke Kuromiya; Kana Aoki; Kojiro Ishibashi; Moe Yotabun; Miho Sekai; Nobuyuki Tanimura; Sayuri Iijima; Susumu Ishikawa; Tomoko Kamasaki; Yuki Akieda; Tohru Ishitani; Takashi Hayashi; Satoshi Toda; Koji Yokoyama; Chol Gyu Lee; Ippei Usami; Haruki Inoue; Ichigaku Takigawa; Estelle Gauquelin; Kaoru Sugimura; Naoya Hino; Yasuyuki FujitaCell Reports, 2022年07月
- The CD44/COL17A1 pathway promotes the formation of multilayered, transformed epitheliaKei Kozawa; Miho Sekai; Kenji Ohba; Shoko Ito; Hiroaki Sako; Takeshi Maruyama; Mai Kakeno; Takanobu Shirai; Keisuke Kuromiya; Tomoko Kamasaki; Koki Kohashi; Shinya Tanaka; Susumu Ishikawa; Nanami Sato; Shota Asano; Hironori Suzuki; Nobuyuki Tanimura; Yohei Mukai; Noriko Gotoh; Mishie Tanino; Shinya Tanaka; Ken Natsuga; Tomoyoshi Soga; Tomonori Nakamura; Yukihiro Yabuta; Mitinori Saitou; Takahiro Ito; Kenkyo Matsuura; Makoto Tsunoda; Toyone Kikumori; Tadashi Iida; Yasuyuki Mizutani; Yuki Miyai; Kozo Kaibuchi; Atsushi Enomoto; Yasuyuki FujitaCurrent Biology, 2021年07月, 筆頭著者
- An improved clonogenic culture method for thymic epithelial cells.Sekai M; Wang J; Minato N; Hamazaki YJournal of immunological methods, 2019年04月, 筆頭著者
- Hassall's corpuscles with cellular-senescence features maintain IFNα production through neutrophils and pDC activation in the thymus.Wang J; Sekai M; Matsui T; Fujii Y; Matsumoto M; Takeuchi O; Minato N; Hamazaki YInternational immunology, 2019年03月05日
- Clonogenic Culture of Mouse Thymic Epithelial Cells.Sekai M; Wang J; Hamazaki YMethods in molecular biology (Clifton, N.J.), 2019年, 筆頭著者
- Physiologic Thymic Involution Underlies Age-Dependent Accumulation of Senescence-Associated CD4(+) T CellsKyosuke Sato; Aiko Kato; Miho Sekai; Yoko Hamazaki; Nagahiro MinatoJOURNAL OF IMMUNOLOGY, 2017年07月
- A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell productionIzumi Ohigashi; Yuki Ohte; Kazuya Setoh; Hiroshi Nakase; Akiko Maekawa; Hiroshi Kiyonari; Yoko Hamazaki; Miho Sekai; Tetsuo Sudo; Yasuharu Tabara; Hiromi Sawai; Yosuke Omae; Rika Yuliwulandari; Yasuhito Tanaka; Masashi Mizokami; Hiroshi Inoue; Masanori Kasahara; Nagahiro Minato; Katsushi Tokunaga; Keiji Tanaka; Fumihiko Matsuda; Shigeo Murata; Yousuke TakahamaJCI Insight, 2017年05月18日
- Obesity accelerates T cell senescence in murine visceral adipose tissueKohsuke Shirakawa; Xiaoxiang Yan; Ken Shinmura; Jin Endo; Masaharu Kataoka; Yoshinori Katsumata; Tsunehisa Yamamoto; Atsushi Anzai; Sarasa Isobe; Naohiro Yoshida; Hiroshi Itoh; Ichiro Manabe; Miho Sekai; Yoko Hamazaki; Keiichi Fukuda; Nagahiro Minato; Motoaki SanoJOURNAL OF CLINICAL INVESTIGATION, 2016年12月
- Medullary thymic epithelial stem cells: role in thymic epithelial cell maintenance and thymic involutionYoko Hamazaki; Miho Sekai; Nagahiro MinatoIMMUNOLOGICAL REVIEWS, 2016年05月
- Relb acts downstream of medullary thymic epithelial stem cells and is essential for the emergence of RANK(+) medullary epithelial progenitorsSong Baik; Miho Sekai; Yoko Hamazaki; William E. Jenkinson; Graham AndersonEUROPEAN JOURNAL OF IMMUNOLOGY, 2016年04月, 査読有り
- Medullary Thymic Epithelial Stem Cells Maintain a Functional Thymus to Ensure Lifelong Central T Cell ToleranceSekai M; HAMAZAKI Y; Minato NImmunity, 2014年11月, 筆頭著者
- Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factorsMiho Sekai; Shizue Tani-ichi; Mitsutoshi Yoneyama; Takashi Fujita; Tatsuo Kina; Koichi IkutaMolecular Immunology, 2013年07月, 筆頭著者
- Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiencyHiroki Tanaka; Akitoshi Tamura; Miho Sekai; Yoko Hamazaki; Nagahiro MinatoCANCER SCIENCE, 2011年04月
- Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cellsYoshinori Katayama; Miho Sekai; Masakazu Hattori; Ichiro Miyoshi; Yoko Hamazaki; Nagahiro MinatoBLOOD, 2009年08月
講演・口頭発表等
- 膵発がんメカニズム解明に基づく超早期がん病変の診断と予防的治療法の開発瀨海 美穂第76回日本細胞生物学会大会, 2024年07月17日, 招待有り
- Identification of a novel precancerous lesion ‘dome-like structure’ in mice and humans瀨海 美穂Rise of Diversity in Science Symposium, 2023年09月28日, 招待有り
- Identification of novel precancerous lesions ‘Dome-like structure’瀨海 美穂Japan-China Interaction meeting, 2023年06月26日, 招待有り
- Basal extrusion of single-oncogenic mutant cells induces dome-like structures with macrophage accumulation瀨海 美穂第23回 日本抗加齢医学会総会, 2023年06月10日, 招待有り
- 胸腺の髄質上皮幹細胞の同定と加齢変化瀨海 美穂日中若手行政官と異分野研究者交流シンポジウム, 2017年11月15日, 招待有り
書籍等出版物
- Ｔ細胞の中枢性自己寛容を生涯にわたり保証する胸腺髄質上皮幹細胞の同定瀨海 美穂; 濱崎洋子; 湊長博ライフサイエンス新着論文レビュー 大学共同利用機関法人 情報・システム研究機構 ライフサイエンス統合データベースセンター, 2015年01月, 査読無し
